                         SEQUENCE LISTING

<110>  MINERVA BIOTECHNOLOGIES CORPORATION
 
<120>  METHOD FOR ANTI-MUC1* CAR T CELL STIMULATION

<130>  13150-70157PCT

<150>  62/640,697
<151>  2018-03-09

<160>  831   

<170>  PatentIn version 3.5

<210>  1
<211>  1255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC1 Receptor

<400>  1

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                165                 170                 175     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            180                 185                 190         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        195                 200                 205             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    210                 215                 220                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
225                 230                 235                 240 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                245                 250                 255     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            260                 265                 270         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        275                 280                 285             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    290                 295                 300                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
305                 310                 315                 320 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                325                 330                 335     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            340                 345                 350         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        355                 360                 365             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    370                 375                 380                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
385                 390                 395                 400 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                405                 410                 415     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            420                 425                 430         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        435                 440                 445             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    450                 455                 460                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
465                 470                 475                 480 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                485                 490                 495     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            500                 505                 510         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        515                 520                 525             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    530                 535                 540                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
545                 550                 555                 560 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                565                 570                 575     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            580                 585                 590         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        595                 600                 605             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    610                 615                 620                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
625                 630                 635                 640 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                645                 650                 655     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            660                 665                 670         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        675                 680                 685             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    690                 695                 700                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
705                 710                 715                 720 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                725                 730                 735     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            740                 745                 750         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        755                 760                 765             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    770                 775                 780                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
785                 790                 795                 800 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                805                 810                 815     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            820                 825                 830         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        835                 840                 845             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    850                 855                 860                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
865                 870                 875                 880 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                885                 890                 895     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            900                 905                 910         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        915                 920                 925             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn 
    930                 935                 940                 


Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser 
945                 950                 955                 960 


Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly 
                965                 970                 975     


Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe 
            980                 985                 990         


Ser Ile Pro Ser His His Ser Asp  Thr Pro Thr Thr Leu  Ala Ser His 
        995                 1000                 1005             


Ser Thr  Lys Thr Asp Ala Ser  Ser Thr His His Ser  Ser Val Pro 
    1010                 1015                 1020             


Pro Leu  Thr Ser Ser Asn His  Ser Thr Ser Pro Gln  Leu Ser Thr 
    1025                 1030                 1035             


Gly Val  Ser Phe Phe Phe Leu  Ser Phe His Ile Ser  Asn Leu Gln 
    1040                 1045                 1050             


Phe Asn  Ser Ser Leu Glu Asp  Pro Ser Thr Asp Tyr  Tyr Gln Glu 
    1055                 1060                 1065             


Leu Gln  Arg Asp Ile Ser Glu  Met Phe Leu Gln Ile  Tyr Lys Gln 
    1070                 1075                 1080             


Gly Gly  Phe Leu Gly Leu Ser  Asn Ile Lys Phe Arg  Pro Gly Ser 
    1085                 1090                 1095             


Val Val  Val Gln Leu Thr Leu  Ala Phe Arg Glu Gly  Thr Ile Asn 
    1100                 1105                 1110             


Val His  Asp Val Glu Thr Gln  Phe Asn Gln Tyr Lys  Thr Glu Ala 
    1115                 1120                 1125             


Ala Ser  Arg Tyr Asn Leu Thr  Ile Ser Asp Val Ser  Val Ser Asp 
    1130                 1135                 1140             


Val Pro  Phe Pro Phe Ser Ala  Gln Ser Gly Ala Gly  Val Pro Gly 
    1145                 1150                 1155             


Trp Gly  Ile Ala Leu Leu Val  Leu Val Cys Val Leu  Val Ala Leu 
    1160                 1165                 1170             


Ala Ile  Val Tyr Leu Ile Ala  Leu Ala Val Cys Gln  Cys Arg Arg 
    1175                 1180                 1185             


Lys Asn  Tyr Gly Gln Leu Asp  Ile Phe Pro Ala Arg  Asp Thr Tyr 
    1190                 1195                 1200             


His Pro  Met Ser Glu Tyr Pro  Thr Tyr His Thr His  Gly Arg Tyr 
    1205                 1210                 1215             


Val Pro  Pro Ser Ser Thr Asp  Arg Ser Pro Tyr Glu  Lys Val Ser 
    1220                 1225                 1230             


Ala Gly  Asn Gly Gly Ser Ser  Leu Ser Tyr Thr Asn  Pro Ala Val 
    1235                 1240                 1245             


Ala Ala  Ala Ser Ala Asn Leu  
    1250                 1255 


<210>  2
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMGFR

<400>  2

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  45  


<210>  3
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME1

<400>  3
atggccaact gtgagcgtac cttcattgcg atcaaaccag atggggtcca gcggggtctt       60

gtgggagaga ttatcaagcg ttttgagcag aaaggattcc gccttgttgg tctgaaattc      120

atgcaagctt ccgaagatct tctcaaggaa cactacgttg acctgaagga ccgtccattc      180

tttgccggcc tggtgaaata catgcactca gggccggtag ttgccatggt ctgggagggg      240

ctgaatgtgg tgaagacggg ccgagtcatg ctcggggaga ccaaccctgc agactccaag      300

cctgggacca tccgtggaga cttctgcata caagttggca ggaacattat acatggcagt      360

gattctgtgg agagtgcaga gaaggagatc ggcttgtggt ttcaccctga ggaactggta      420

gattacacga gctgtgctca gaactggatc tatgaatga                             459


<210>  4
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME1

<400>  4

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Gly Leu Trp Phe His Pro Glu Glu Leu Val Asp Tyr Thr Ser 
    130                 135                 140                 


Cys Ala Gln Asn Trp Ile Tyr Glu 
145                 150         


<210>  5
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7

<400>  5
atgaatcata gtgaaagatt cgttttcatt gcagagtggt atgatccaaa tgcttcactt       60

cttcgacgtt atgagctttt attttaccca ggggatggat ctgttgaaat gcatgatgta      120

aagaatcatc gcaccttttt aaagcggacc aaatatgata acctgcactt ggaagattta      180

tttataggca acaaagtgaa tgtcttttct cgacaactgg tattaattga ctatggggat      240

caatatacag ctcgccagct gggcagtagg aaagaaaaaa cgctagccct aattaaacca      300

gatgcaatat caaaggctgg agaaataatt gaaataataa acaaagctgg atttactata      360

accaaactca aaatgatgat gctttcaagg aaagaagcat tggattttca tgtagatcac      420

cagtcaagac cctttttcaa tgagctgatc cagtttatta caactggtcc tattattgcc      480

atggagattt taagagatga tgctatatgt gaatggaaaa gactgctggg acctgcaaac      540

tctggagtgg cacgcacaga tgcttctgaa agcattagag ccctctttgg aacagatggc      600

ataagaaatg cagcgcatgg ccctgattct tttgcttctg cggccagaga aatggagttg      660

ttttttcctt caagtggagg ttgtgggccg gcaaacactg ctaaatttac taattgtacc      720

tgttgcattg ttaaacccca tgctgtcagt gaaggactgt tgggaaagat cctgatggct      780

atccgagatg caggttttga aatctcagct atgcagatgt tcaatatgga tcgggttaat      840

gttgaggaat tctatgaagt ttataaagga gtagtgaccg aatatcatga catggtgaca      900

gaaatgtatt ctggcccttg tgtagcaatg gagattcaac agaataatgc tacaaagaca      960

tttcgagaat tttgtggacc tgctgatcct gaaattgccc ggcatttacg ccctggaact     1020

ctcagagcaa tctttggtaa aactaagatc cagaatgctg ttcactgtac tgatctgcca     1080

gaggatggcc tattagaggt tcaatacttc ttcaagatct tggataatta g              1131


<210>  6
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7

<400>  6

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr 
225                 230                 235                 240 


Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys 
                245                 250                 255     


Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln 
            260                 265                 270         


Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr 
        275                 280                 285             


Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser 
    290                 295                 300                 


Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr 
305                 310                 315                 320 


Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu 
                325                 330                 335     


Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn 
            340                 345                 350         


Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln 
        355                 360                 365             


Tyr Phe Phe Lys Ile Leu Asp Asn 
    370                 375     


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7 peptide 1 (A domain)

<400>  7

Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser 
1               5                   10                  15      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A peptide 2 (A domain)

<400>  8

Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser 
1               5                   10      


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B peptide 1 (B domain)

<400>  9

Asp Ala Gly Phe Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg 
1               5                   10                  15      


Val Asn Val Glu 
            20  


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B peptide 2 (B domain)

<400>  10

Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu 
1               5                   10                  15      


<210>  11
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B peptide 3 (B domain)

<400>  11

Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn Ala Val His Cys Thr Asp 
1               5                   10                  15      


Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe 
            20                  25                  


<210>  12
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 Heavy chain variable region sequence

<400>  12
gaggtgaagg tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgtag tctctggatt cactttcagt agatatggca tgtcttgggt tcgccagact      120

ccaggcaaga ggctggagtg ggtcgcaacc attagtggtg gcggtactta catctactat      180

ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt atcactgtac aagggataac      300

tacggtagga actacgacta cggtatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctca                                                                 366


<210>  13
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 Heavy chain variable region sequence

<400>  13

Glu Val Lys Val Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr His Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  14
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable framework region 1 (FWR1) sequence

<400>  14
gaggtgaagg tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgtag tctct                                                        75


<210>  15
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable framework region 1 (FWR1) sequence

<400>  15

Glu Val Lys Val Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  16
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  16
ggattcactt tcagtagata tggcatgtct                                        30


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  17

Arg Tyr Gly Met Ser 
1               5   


<210>  18
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable framework region 2 (FWR2) sequence

<400>  18
tgggttcgcc agactccagg caagaggctg gagtgggtcg ca                          42


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable framework region 2 (FWR2) sequence

<400>  19

Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  20
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  20
accattagtg gtggcggtac ttacatctac tatccagaca gtgtgaaggg g                51


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  21

Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  22
cgattcacca tctccagaga caatgccaag aacaccctgt acctgcaaat gagcagtctg       60

aagtctgagg acacagccat gtatcactgt acaagg                                 96


<210>  23
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  23

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr His Cys Thr Arg 
            20                  25                  30          


<210>  24
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  24
gataactacg gtaggaacta cgactacggt atggactac                              39


<210>  25
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  25

Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr 
1               5                   10              


<210>  26
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*03 heavy chain variable region sequence

<400>  26
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gaga            294


<210>  27
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*03 heavy chain variable region sequence

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  28
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*01 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  28
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt                                        90


<210>  29
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*01 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  30
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*01 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  30
agctatagca tgaac                                                        15


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*01 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  31

Ser Tyr Ser Met Asn 
1               5   


<210>  32
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*01 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  32
tgggtccgcc aggctccagg gaaggggctg gagtgggtct ca                          42


<210>  33
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*01 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  33

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  34
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*01 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  34
tccattagta gtagtagtag ttacatatac tacgcagact cagtgaaggg c                51


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*01 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  35

Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*01 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  36
cgattcacca tctccagaga caacgccaag aactcactgt atctgcaaat gaacagcctg       60

agagccgagg acacggctgt gtattactgt gcgaga                                 96


<210>  37
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*01 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  37

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  38
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable region sequence

<400>  38
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa caccctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagc                                                                 366


<210>  39
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable region sequence

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  40
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable framework region 1 (FWR1) acid 
       sequence

<400>  40
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt                                        90


<210>  41
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable framework region 1 (FWR1) acid 
       sequence

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  42
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  42
aggtatggca tgagc                                                        15


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  43

Arg Tyr Gly Met Ser 
1               5   


<210>  44
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable framework region 2 (FWR2) acid 
       sequence

<400>  44
tgggtccgcc aggctccagg gaagaggctg gagtgggtct ca                          42


<210>  45
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable framework region 2 (FWR2) acid 
       sequence

<400>  45

Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val Ser 
1               5                   10                  


<210>  46
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  46
accattagtg gcggaggcac ctacatatac tacccagact cagtgaaggg c                51


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  47

Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  48
cgattcacca tctccagaga caacgccaag aacaccctgt atctgcaaat gaacagcctg       60

agagccgagg acacggctgt gtattactgt accaga                                 96


<210>  49
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  49

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  50
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  50
gataactatg gccgcaacta tgattatggc atggattat                              39


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  51

Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr 
1               5                   10              


<210>  52
<211>  1442
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 IgG2 heavy chain synthesized by Genescript

<400>  52
gaattctaag cttgggccac catggaactg gggctccgct gggttttcct tgttgctatt       60

ttagaaggtg tccagtgtga ggtgcagctg gtggagtctg ggggaggcct ggtcaagcct      120

ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag gtatggcatg      180

agctgggtcc gccaggctcc agggaagagg ctggagtggg tctcaaccat tagtggcgga      240

ggcacctaca tatactaccc agactcagtg aagggccgat tcaccatctc cagagacaac      300

gccaagaaca ccctgtatct gcaaatgaac agcctgagag ccgaggacac ggctgtgtat      360

tactgtacca gagataacta tggccgcaac tatgattatg gcatggatta ttggggccag      420

ggcaccctgg tgaccgtgag cagcgcctcc accaagggcc catcggtctt ccccctggcg      480

ccctgctcca ggagcacctc cgagagcaca gccgccctgg gctgcctggt caaggactac      540

ttccccgaac cggtgacggt gtcgtggaac tcaggcgctc tgaccagcgg cgtgcacacc      600

ttcccagctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      660

tccagcaact tcggcaccca gacctacacc tgcaacgtag atcacaagcc cagcaacacc      720

aaggtggaca agacagttga gcgcaaatgt tgtgtcgagt gcccaccgtg cccagcacca      780

cctgtggcag gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac gtgcgtggtg gtggacgtga gccacgaaga ccccgaggtc      900

cagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccacgggag      960

gagcagttca acagcacgtt ccgtgtggtc agcgtcctca ccgttgtgca ccaggactgg     1020

ctgaacggca aggagtacaa gtgcaaggtc tccaacaaag gcctcccagc ccccatcgag     1080

aaaaccatct ccaaaaccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctac     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acacctccca tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aatagtaagt ttaaactcta     1440

ga                                                                    1442


<210>  53
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 IgG2 heavy chain synthesized by Genescript


<220>
<221>  misc_feature
<222>  (477)..(477)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Glu Phe Ala Trp Ala Thr Met Glu Leu Gly Leu Arg Trp Val Phe Leu 
1               5                   10                  15      


Val Ala Ile Leu Glu Gly Val Gln Cys Glu Val Gln Leu Val Glu Ser 
            20                  25                  30          


Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        35                  40                  45              


Ala Ser Gly Phe Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln 
    50                  55                  60                  


Ala Pro Gly Lys Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly 
65                  70                  75                  80  


Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                85                  90                  95      


Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            100                 105                 110         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg 
        115                 120                 125             


Asn Tyr Asp Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Thr Leu Xaa 
465                 470                 475         


<210>  54
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG2 heavy chain constant region sequence

<400>  54
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaata g                                                981


<210>  55
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 heavy chain constant region sequence

<400>  55

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  56
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 IgG1 heavy chain sequence

<400>  56
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa cccactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtcc cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagcgcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgacagtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaatgat aa                        1362


<210>  57
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 IgG1 heavy chain sequence

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Pro Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Pro Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  58
<211>  996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 heavy chain constant region sequence

<400>  58
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgaca gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tgataa                                996


<210>  59
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 heavy chain constant region sequence

<400>  59

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  60
<211>  560
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 heavy chain constant region gBLOCK#1 sequence

<400>  60
atggcatgga ttattggggc cagggcaccc tggtgaccgt gagcagcgct agcaccaagg       60

gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc acagcggccc      120

tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg      180

ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga ctctactccc      240

tcagcagcgt ggtgacagtg ccctccagca gcttgggcac ccagacctac atctgcaacg      300

tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa tcttgtgaca      360

aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg tcagtcttcc      420

tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag gtcacatgcg      480

tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac gtggacggcg      540

tggaggtgca taatgccaag                                                  560


<210>  61
<211>  557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 heavy chain constant region gBLOCK#2 sequence

<400>  61
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       60

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      120

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      180

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      240

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      300

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      360

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      420

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      480

cagaagagcc tctccctgtc tccgggtaaa tgataagttt aaacccgctg atcagcctcg      540

actgtgcctt ctagttg                                                     557


<210>  62
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 heavy chain variable region overlapping sequence

<400>  62
atggcatgga ttattggggc cagggcaccc t                                      31


<210>  63
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain constant region overlapping region sequence

<400>  63
tacgtggacg gcgtggaggt gcataatgcc aag                                    33


<210>  64
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDNA3.1 V5 and pSECTag2 overlapping sequence

<400>  64
ccgctgatca gcctcgactg tgccttctag ttg                                    33


<210>  65
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 Light Chain variable region sequence

<400>  65
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga ggaggtcacc       60

ctaacctgca gtgccacctc aagtgtaagt tacatacact ggttccagca gaggccaggc      120

acttctccca aactctggat ttatagcaca tccaacctgg cttctggagt ccctgttcgc      180

ttcagtggca gtggatatgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcaaagg agtagttccc cattcacgtt cggctcgggg      300

acaaagttgg aaataaaa                                                    318


<210>  66
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 Light Chain variable region sequence

<400>  66

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Glu Val Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Arg Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Tyr Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  67
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable framework region 1 (FWR1) sequence

<400>  67
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga ggaggtcacc       60

ctaacctgc                                                               69


<210>  68
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable framework region 1 (FWR1) sequence

<400>  68

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Glu Val Thr Leu Thr Cys 
            20              


<210>  69
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  69
agtgccacct caagtgtaag ttacatacac                                        30


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  70

Ser Ala Thr Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210>  71
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable framework region 2 (FWR2) sequence

<400>  71
tggttccagc agaggccagg cacttctccc aaactctgga tttat                       45


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable framework region 2 (FWR2) sequence

<400>  72

Trp Phe Gln Gln Arg Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
1               5                   10                  15  


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  73
agcacatcca acctggcttc t                                                 21


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  74

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  75
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable framework region 3 (FWR3) sequence

<400>  75
ggagtccctg ttcgcttcag tggcagtgga tatgggacct cttactctct cacaatcagc       60

cgaatggagg ctgaagatgc tgccacttat tactgc                                 96


<210>  76
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable framework region 3 (FWR3) sequence

<400>  76

Gly Val Pro Val Arg Phe Ser Gly Ser Gly Tyr Gly Thr Ser Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  77
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  77
cagcaaagga gtagttcccc attcacg                                           27


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  78

Gln Gln Arg Ser Ser Ser Pro Phe Thr 
1               5                   


<210>  79
<211>  287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable region sequence

<400>  79
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggagagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctcc                    287


<210>  80
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable region sequence

<400>  80

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


<210>  81
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  81
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgc                                                               69


<210>  82
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  82

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  83
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  83
agggccagtc agagtgttag cagctactta gcc                                    33


<210>  84
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  84

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  85
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable framework region 2 (FWR2) 
       sequence

<400>  85
tggtaccaac agaaacctgg ccaggctccc aggctcctca tctat                       45


<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable framework region 2 (FWR2) 
       sequence

<400>  86

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  87
gatgcatcca acagggccac t                                                 21


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  88

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  89
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable framework region 3 (FWR3) 
       sequence

<400>  89
ggcatcccag ccaggttcag tggcagtggg tctgggagag acttcactct caccatcagc       60

agcctagagc ctgaagattt tgcagtttat tactgt                                 96


<210>  90
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable framework region 3 (FWR3) 
       sequence

<400>  90

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  91
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable complementarity determining 
       regions3 (CDR3) sequence

<400>  91
cagcagcgta gcaactggcc tcc                                               23


<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV3-11*02 light chain variable complementarity determining 
       regions3 (CDR3) sequence

<400>  92

Gln Gln Arg Ser Asn Trp Pro Pro 
1               5               


<210>  93
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable region sequence

<400>  93
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctcacctgca gcgccaccag cagtgttagc tacatccact ggtaccaaca gaggcctggc      120

cagagcccca ggctcctcat ctatagcacc tccaacctgg ccagcggcat cccagccagg      180

ttcagtggca gtgggtctgg gagcgactac actctcacca tcagcagcct agagcctgaa      240

gattttgcag tttattactg tcagcagcgt agcagctccc ctttcacctt tggcagcggc      300

accaaagtgg aaattaaa                                                    318


<210>  94
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable region sequence

<400>  94

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  95
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  95
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctcacctgc                                                               69


<210>  96
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  96

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Thr Cys 
            20              


<210>  97
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  97
agcgccacca gcagtgttag ctacatccac                                        30


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  98

Ser Ala Thr Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210>  99
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy light variable framework region 2 (FWR2) acid 
       sequence

<400>  99
tggtaccaac agaggcctgg ccagagcccc aggctcctca tctat                       45


<210>  100
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy light variable framework region 2 (FWR2) acid 
       sequence

<400>  100

Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  101
agcacctcca acctggccag c                                                 21


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  102

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  103
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable framework region 3 (FWR3) acid 
       sequence

<400>  103
ggcatcccag ccaggttcag tggcagtggg tctgggagcg actacactct caccatcagc       60

agcctagagc ctgaagattt tgcagtttat tactgt                                 96


<210>  104
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable framework region 3 (FWR3) acid 
       sequence

<400>  104

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  105
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  105
cagcagcgta gcagctcccc tttcacc                                           27


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  106

Gln Gln Arg Ser Ser Ser Pro Phe Thr 
1               5                   


<210>  107
<211>  740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 Kappa light chain synthesized by Genescript

<400>  107
gaattctaag cttgggccac catggaagcc ccagcgcagc ttctcttcct cctgctactc       60

tggctcccag ataccactgg agaaattgtg ttgacacagt ctccagccac cctgtctttg      120

tctccagggg aaagagccac cctcacctgc agcgccacca gcagtgttag ctacatccac      180

tggtaccaac agaggcctgg ccagagcccc aggctcctca tctatagcac ctccaacctg      240

gccagcggca tcccagccag gttcagtggc agtgggtctg ggagcgacta cactctcacc      300

atcagcagcc tagagcctga agattttgca gtttattact gtcagcagcg tagcagctcc      360

cctttcacct ttggcagcgg caccaaagtg gaaattaaaa ggacggtggc tgcaccatct      420

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      480

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      540

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      600

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      660

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      720

tagtaagttt aaactctaga                                                  740


<210>  108
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 Kappa light chain synthesized by Genescript


<220>
<221>  misc_feature
<222>  (243)..(243)
<223>  Xaa can be any naturally occurring amino acid

<400>  108

Glu Phe Ala Trp Ala Thr Met Glu Ala Pro Ala Gln Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Ile Val Leu Thr Gln 
            20                  25                  30          


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr 
        35                  40                  45              


Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Val 
225                 230                 235                 240 


Thr Leu Xaa 
            


<210>  109
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Kappa light chain constant region sequence

<400>  109
aggacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttag                                             324


<210>  110
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Kappa light chain constant region sequence

<400>  110

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  111
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 lambda light chain sequence

<400>  111
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctcacctgca gcgccaccag cagtgttagc tacatccact ggtaccaaca gaggcctggc      120

cagagcccca ggctcctcat ctatagcacc tccaacctgg ccagcggcat cccagccagg      180

ttcagtggca gtgggtctgg gagcgactac actctcacca tcagcagcct agagcctgaa      240

gattttgcag tttattactg tcagcagcgt agcagctccc ctttcacctt tggcagcggc      300

accaaagtgg aaattaaagg tcagcccaag gctgccccct cggtcactct gttcccgccc      360

tcctctgagg agcttcaagc caacaaggcc acactggtgt gtctcataag tgacttctac      420

ccgggagccg tgacagtggc ctggaaggca gatagcagcc ccgtcaaggc gggagtggag      480

accaccacac cctccaaaca aagcaacaac aagtacgcgg ccagcagcta tctgagcctg      540

acgcctgagc agtggaagtc ccacagaagc tacagctgcc aggtcacgca tgaagggagc      600

accgtggaga agacagtggc ccctacagaa tgttcatagt aa                         642


<210>  112
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 lambda light chain sequence

<400>  112

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  113
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized lambda light chain constant region sequence

<400>  113
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttcata gtaa                                             324


<210>  114
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized lambda light chain constant region sequence

<400>  114

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  115
<211>  614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human lambda light chain constant region gBLOCK#3 sequence

<400>  115
agcgccacca gcagtgttag ctacatccac tggtaccaac agaggcctgg ccagagcccc       60

aggctcctca tctatagcac ctccaacctg gccagcggca tcccagccag gttcagtggc      120

agtgggtctg ggagcgacta cactctcacc atcagcagcc tagagcctga agattttgca      180

gtttattact gtcagcagcg tagcagctcc cctttcacct ttggcagcgg caccaaagtg      240

gaaattaaag gtcagcccaa ggctgccccc tcggtcactc tgttcccgcc ctcctctgag      300

gagcttcaag ccaacaaggc cacactggtg tgtctcataa gtgacttcta cccgggagcc      360

gtgacagtgg cctggaaggc agatagcagc cccgtcaagg cgggagtgga gaccaccaca      420

ccctccaaac aaagcaacaa caagtacgcg gccagcagct atctgagcct gacgcctgag      480

cagtggaagt cccacagaag ctacagctgc caggtcacgc atgaagggag caccgtggag      540

aagacagtgg cccctacaga atgttcatag taagtttaaa cccgctgatc agcctcgact      600

gtgccttcta gttg                                                        614


<210>  116
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 light chain variable region overlapping sequence

<400>  116
agcgccacca gcagtgttag ctacatccac t                                      31


<210>  117
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDNA3.1 V5 and pSECTag2 overlapping sequence

<400>  117
ccgctgatca gcctcgactg tgccttctag ttg                                    33


<210>  118
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable region sequence

<400>  118
gaggtccagc tggaggagtc agggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt ggctatgcca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtactta tatctactat      180

ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcgcag ggaccacggt caccgtctcc      360

tccgccaaaa cgacaccccc atctgtctat                                       390


<210>  119
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable region sequence

<400>  119

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr 
    130 


<210>  120
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable framework region 1 (FWR1) sequence

<400>  120
gaggtccagc tggaggagtc agggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt                                        90


<210>  121
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable framework region 1 (FWR1) sequence

<400>  121

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  122
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  122
ggctatgcca tgtct                                                        15


<210>  123
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  123

Gly Tyr Ala Met Ser 
1               5   


<210>  124
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable framework region 2 (FWR2) sequence

<400>  124
tgggttcgcc agactccgga gaagaggctg gagtgggtcg ca                          42


<210>  125
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable framework region 2 (FWR2) sequence

<400>  125

Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  126
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  126
accattagta gtggtggtac ttatatctac tatccagaca gtgtgaaggg g                51


<210>  127
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  127

Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  128
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable framework region 3 (FWR3) sequence

<400>  128
cgattcacca tctccagaga caatgccaag aacaccctgt acctgcaaat gagcagtctg       60

aggtctgagg acacggccat gtattactgt gcaaga                                 96


<210>  129
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable framework region 3 (FWR3) sequence

<400>  129

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  130
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  130
cttggggggg ataattacta cgaatacttc gatgtc                                 36


<210>  131
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  131

Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val 
1               5                   10          


<210>  132
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable region sequence

<400>  132
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gaga            294


<210>  133
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable region sequence

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  134
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  134
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt                                        90


<210>  135
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  135

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  136
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  136
agctatagca tgaac                                                        15


<210>  137
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  137

Ser Tyr Ser Met Asn 
1               5   


<210>  138
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  138
gggtccgcca ggctccaggg aaggggctgg agtgggtctc a                           41


<210>  139
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  139

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  140
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  140
tccattagta gtagtagtag ttacatatac tacgcagact cagtgaaggg c                51


<210>  141
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  141

Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  142
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  142
cgattcacca tctccagaga caacgccaag aactcactgt atctgcaaat gaacagcctg       60

agagccgagg acacggccgt gtattactgt gcgaga                                 96


<210>  143
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  143

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  144
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable region sequence

<400>  144
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tcc                                                                    363


<210>  145
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable region sequence

<400>  145

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  146
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  146
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt                                        90


<210>  147
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  147

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  148
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  148
ggctatgcca tgagc                                                        15


<210>  149
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  149

Gly Tyr Ala Met Ser 
1               5   


<210>  150
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  150
tgggtccgcc aggctccagg gaaggggctg gagtgggtct caa                         43


<210>  151
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  151

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  152
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  152
accattagta gtggcggaac ctacatatac taccccgact cagtgaaggg c                51


<210>  153
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  153

Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  154
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  154
cgattcacca tctccagaga caacgccaag aactcactgt atctgcaaat gaacagcctg       60

agagccgagg acacggccgt gtattactgt gcgaga                                 96


<210>  155
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  155

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  156
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  156
cttggggggg ataattacta cgaatacttc gatgtc                                 36


<210>  157
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  157

Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val 
1               5                   10          


<210>  158
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 IgG1 heavy chain sequence

<400>  158
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg acagtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaatgataa                            1359


<210>  159
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 IgG1 heavy chain sequence

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  160
<211>  616
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 gBLOCK#4 sequence

<400>  160
actcactata gggagaccca agctggctag ttaagcttgg gccaccatgg agacagacac       60

actcctgcta tgggtactgc tgctctgggt tccaggttcc actggtgacg aggtgcagct      120

ggtggagtct gggggaggcc tggtcaagcc tggggggtcc ctgagactct cctgtgcagc      180

ctctggattc accttcagtg gctatgccat gagctgggtc cgccaggctc cagggaaggg      240

gctggagtgg gtctcaacca ttagtagtgg cggaacctac atatactacc ccgactcagt      300

gaagggccga ttcaccatct ccagagacaa cgccaagaac tcactgtatc tgcaaatgaa      360

cagcctgaga gccgaggaca cggccgtgta ttactgtgcg agacttgggg gggataatta      420

ctacgaatac ttcgatgtct ggggcaaagg gaccacggtc accgtctcct ccgctagcac      480

caagggccca tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc      540

ggccctgggc tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc      600

aggcgccctg accagc                                                      616


<210>  161
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDNA3.1 V5 overlapping sequence

<400>  161
actcactata gggagaccca agctggctag tt                                     32


<210>  162
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 constant region overlapping sequence

<400>  162
gacggtgtcg tggaactcag gcgccctgac cagc                                   34


<210>  163
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 IgG2 heavy chain sequence

<400>  163
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgtggcagg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttgtgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccagcc cccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa atagtaa                                         1347


<210>  164
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 IgG2 heavy chain sequence

<400>  164

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  165
<211>  549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 gBLOCK#5 sequence

<400>  165
tgctctgggt tccaggttcc actggtgacg cggcccagcc ggccgaggtg cagctggtgg       60

agtctggggg aggcctggtc aagcctgggg ggtccctgag actctcctgt gcagcctctg      120

gattcacctt cagtggctat gccatgagct gggtccgcca ggctccaggg aaggggctgg      180

agtgggtctc aaccattagt agtggcggaa cctacatata ctaccccgac tcagtgaagg      240

gccgattcac catctccaga gacaacgcca agaactcact gtatctgcaa atgaacagcc      300

tgagagccga ggacacggcc gtgtattact gtgcgagact tgggggggat aattactacg      360

aatacttcga tgtctggggc aaagggacca cggtcaccgt ctcctccgcc tccaccaagg      420

gcccatcggt cttccccctg gcgccctgct ccaggagcac ctccgagagc acagccgccc      480

tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg      540

ctctgacca                                                              549


<210>  166
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSEC Tag2 overlapping sequence

<400>  166
tgctctgggt tccaggttcc actggtgacg c                                      31


<210>  167
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG2 constant region overlapping sequence

<400>  167
gacggtgtcg tggaactcag gcgctctgac ca                                     32


<210>  168
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable region sequence

<400>  168
gacattgtga tcacacagtc tacagcttcc ttaggtgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagagac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccgttc      300

acgttcggag gggggaccaa gctggagata aaacgggctg atgctgcacc aactgtatcc      360


<210>  169
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable region sequence

<400>  169

Asp Ile Val Ile Thr Gln Ser Thr Ala Ser Leu Gly Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Thr Val Ser 
        115                 120 


<210>  170
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable framework region 1 (FWR1) sequence

<400>  170
gacattgtga tcacacagtc tacagcttcc ttaggtgtat ctctggggca gagggccacc       60

atctcatgc                                                               69


<210>  171
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable framework region 1 (FWR1) sequence

<400>  171

Asp Ile Val Ile Thr Gln Ser Thr Ala Ser Leu Gly Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys 
            20              


<210>  172
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  172
agggccagca aaagtgtcag tacatctggc tatagttata tgcac                       45


<210>  173
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  173

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  174
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable framework region 2 (FWR2) sequence

<400>  174
tggtaccaac agagaccagg acagccaccc aaactcctca tctat                       45


<210>  175
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable framework region 2 (FWR2) sequence

<400>  175

Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  176
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  176
cttgcatcca acctagaatc                                                   20


<210>  177
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  177

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  178
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable framework region 3 (FWR3) sequence

<400>  178
tggggtccct gccaggttca gtggcagtgg gtctgggaca gacttcaccc tcaacatcca       60

tcctgtggag gaggaggatg ctgcaaccta ttactgt                                97


<210>  179
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable framework region 3 (FWR3) sequence

<400>  179

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  180
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  180
cagcacagta gggagcttcc gttcacg                                           27


<210>  181
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  181

Gln His Ser Arg Glu Leu Pro Phe Thr 
1               5                   


<210>  182
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV7-3*01 light chain variable region sequence

<400>  182
gacattgtgc tgacccagtc tccagcctcc ttggccgtgt ctccaggaca gagggccacc       60

atcacctgca gagccagtga gagtgtcagt ttcttgggaa taaacttaat tcactggtat      120

cagcagaaac caggacaacc tcctaaactc ctgatttacc aagcatccaa taaagacact      180

ggggtcccag ccaggttcag cggcagtggg tctgggaccg atttcaccct cacaattaat      240

cctgtggaag ctaatgatac tgcaaattat tactgtctgc agagtaagaa ttttcctccc      300

aca                                                                    303


<210>  183
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV7-3*01 light chain variable region sequence

<400>  183

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Phe Leu 
            20                  25                  30          


Gly Ile Asn Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Gln Ala Ser Asn Lys Asp Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Leu Gln Ser Lys 
                85                  90                  95      


Asn Phe Pro Pro Thr 
            100     


<210>  184
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV7-3*01 light chain variable framework region 1 (FWR1) 
       sequence

<400>  184
gacattgtgc tgacccagtc tccagcctcc ttggccgtgt ctccaggaca gagggccacc       60

atcacctgc                                                               69


<210>  185
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV7-3*01 light chain variable framework region 1 (FWR1) 
       sequence

<400>  185

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys 
            20              


<210>  186
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV7-3*01 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  186
agagccagtg agagtgtcag tttcttggga ataaacttaa ttcac                       45


<210>  187
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV7-3*01 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  187

Arg Ala Ser Glu Ser Val Ser Phe Leu Gly Ile Asn Leu Ile His 
1               5                   10                  15  


<210>  188
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV7-3*01 light chain variable framework region 2 (FWR2) 
       sequence

<400>  188
tggtatcagc agaaaccagg acaacctcct aaactcctga tttac                       45


<210>  189
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV7-3*01 light chain variable framework region 2 (FWR2) 
       sequence

<400>  189

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  190
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV7-3*01 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  190
caagcatcca ataaagacac t                                                 21


<210>  191
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV7-3*01 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  191

Gln Ala Ser Asn Lys Asp Thr 
1               5           


<210>  192
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV7-3*01 light chain variable framework region 3 (FWR3) 
       sequence

<400>  192
ggggtcccag ccaggttcag cggcagtggg tctgggaccg atttcaccct cacaattaat       60

cctgtggaag ctaatgatac tgcaaattat tactgt                                 96


<210>  193
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV7-3*01 light chain variable framework region 3 (FWR3) 
       sequence

<400>  193

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys 
            20                  25                  30          


<210>  194
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable region sequence

<400>  194
gacattgtgc tgacccagtc tccagcctcc ttggccgtgt ctccaggaca gagggccacc       60

atcacctgca gagccagtaa gagtgtcagt accagcggat actcctacat gcactggtat      120

cagcagaaac caggacaacc tcctaaactc ctgatttacc tggcatccaa tctggagagc      180

ggggtcccag ccaggttcag cggcagtggg tctgggaccg atttcaccct cacaattaat      240

cctgtggaag ctaatgatac tgcaaattat tactgtcagc acagtaggga gctgcctttc      300

acattcggcg gagggaccaa ggtggagatc aaacgaact                             339


<210>  195
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable region sequence

<400>  195

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr 
    


<210>  196
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  196
gacattgtgc tgacccagtc tccagcctcc ttggccgtgt ctccaggaca gagggccacc       60

atcacctgc                                                               69


<210>  197
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  197

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys 
            20              


<210>  198
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  198
agagccagta agagtgtcag taccagcgga tactcctaca tgcac                       45


<210>  199
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  199

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  200
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy light variable framework region 2 (FWR2) acid 
       sequence

<400>  200
tggtatcagc agaaaccagg acaacctcct aaactcctga tttac                       45


<210>  201
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy light variable framework region 2 (FWR2) acid 
       sequence

<400>  201

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  202
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  202
ctggcatcca atctggagag c                                                 21


<210>  203
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  203

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  204
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable framework region 3 (FWR3) acid 
       sequence

<400>  204
ggggtcccag ccaggttcag cggcagtggg tctgggaccg atttcaccct cacaattaat       60

cctgtggaag ctaatgatac tgcaaattat tactgt                                 96


<210>  205
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable framework region 3 (FWR3) acid 
       sequence

<400>  205

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys 
            20                  25                  30          


<210>  206
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  206
cagcacagta gggagctgcc tttcaca                                           27


<210>  207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  207

Gln His Ser Arg Glu Leu Pro Phe Thr 
1               5                   


<210>  208
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  208
ctgcagagta agaattttcc tcccaca                                           27


<210>  209
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  209

Leu Gln Ser Lys Asn Phe Pro Pro Thr 
1               5                   


<210>  210
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 gBLOCK#6 sequence (Kappa light chain in pCDNA3.1 V5)

<400>  210
actcactata gggagaccca agctggctag ttaagcttgg gccaccatgg agacagacac       60

actcctgcta tgggtactgc tgctctgggt tccaggttcc actggtgacg acattgtgct      120

gacccagtct ccagcctcct tggccgtgtc tccaggacag agggccacca tcacctgcag      180

agccagtaag agtgtcagta ccagcggata ctcctacatg cactggtatc agcagaaacc      240

aggacaacct cctaaactcc tgatttacct ggcatccaat ctggagagcg gggtcccagc      300

caggttcagc ggcagtgggt ctgggaccga tttcaccctc acaattaatc ctgtggaagc      360

taatgatact gcaaattatt actgtcagca cagtagggag ctgcctttca cattcggcgg      420

agggaccaag gtggagatca aacgaactac ggtggctgca ccatctgtct tcatcttccc      480

gccatctgat gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt      540

ctatcccaga gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc      600

ccaggagagt gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct      660

gacgctgagc aaagcagact acgagaaaca caaagtctac gcctgcgaag tcacccatca      720

gggcctgagc tcgcccgtca caaagagctt caacagggga gagtgttagt aagtttaaac      780

ccgctgatca gcctcgactg tgccttctag ttg                                   813


<210>  211
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDNA3.1 V5 5' overlapping sequence

<400>  211
actcactata gggagaccca agctggctag tt                                     32


<210>  212
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDNA3.1 V5 3' overlapping sequence

<400>  212
ccgctgatca gcctcgactg tgccttctag ttg                                    33


<210>  213
<211>  748
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 gBLOCK#7 sequence (Kappa light chain in pSEC Tag2)

<400>  213
tgctctgggt tccaggttcc actggtgacg cggcccagcc ggccgacatt gtgctgaccc       60

agtctccagc ctccttggcc gtgtctccag gacagagggc caccatcacc tgcagagcca      120

gtaagagtgt cagtaccagc ggatactcct acatgcactg gtatcagcag aaaccaggac      180

aacctcctaa actcctgatt tacctggcat ccaatctgga gagcggggtc ccagccaggt      240

tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg gaagctaatg      300

atactgcaaa ttattactgt cagcacagta gggagctgcc tttcacattc ggcggaggga      360

ccaaggtgga gatcaaacga actacggtgg ctgcaccatc tgtcttcatc ttcccgccat      420

ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat aacttctatc      480

ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt aactcccagg      540

agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc accctgacgc      600

tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc catcagggcc      660

tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttagtaagtt taaacccgct      720

gatcagcctc gactgtgcct tctagttg                                         748


<210>  214
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSEC Tag2 5' overlapping sequence

<400>  214
tgctctgggt tccaggttcc actggtgacg c                                      31


<210>  215
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSEC Tag2 3' overlapping sequence

<400>  215
ccgctgatca gcctcgactg tgccttctag ttg                                    33


<210>  216
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 gBLOCK#8 sequence (lambda light chain in pCDNA3.1 
       V5)

<400>  216
actcactata gggagaccca agctggctag ttaagcttgg gccaccatgg agacagacac       60

actcctgcta tgggtactgc tgctctgggt tccaggttcc actggtgacg acattgtgct      120

gacccagtct ccagcctcct tggccgtgtc tccaggacag agggccacca tcacctgcag      180

agccagtaag agtgtcagta ccagcggata ctcctacatg cactggtatc agcagaaacc      240

aggacaacct cctaaactcc tgatttacct ggcatccaat ctggagagcg gggtcccagc      300

caggttcagc ggcagtgggt ctgggaccga tttcaccctc acaattaatc ctgtggaagc      360

taatgatact gcaaattatt actgtcagca cagtagggag ctgcctttca cattcggcgg      420

agggaccaag gtggagatca aacgaactgg tcagcccaag gctgccccct cggtcactct      480

gttcccgccc tcctctgagg agcttcaagc caacaaggcc acactggtgt gtctcataag      540

tgacttctac ccgggagccg tgacagtggc ctggaaggca gatagcagcc ccgtcaaggc      600

gggagtggag accaccacac cctccaaaca aagcaacaac aagtacgcgg ccagcagcta      660

tctgagcctg acgcctgagc agtggaagtc ccacagaagc tacagctgcc aggtcacgca      720

tgaagggagc accgtggaga agacagtggc ccctacagaa tgttcatagt aagtttaaac      780

ccgctgatca gcctcgactg tgccttctag ttg                                   813


<210>  217
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDNA3.1 V5 5' overlapping sequence

<400>  217
actcactata gggagaccca agctggctag tt                                     32


<210>  218
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDNA3.1 V5 3' overlapping sequence

<400>  218
ccgctgatca gcctcgactg tgccttctag ttg                                    33


<210>  219
<211>  748
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 gBLOCK#9 sequence (lambda light chain in pSEC Tag2)

<400>  219
tgctctgggt tccaggttcc actggtgacg cggcccagcc ggccgacatt gtgctgaccc       60

agtctccagc ctccttggcc gtgtctccag gacagagggc caccatcacc tgcagagcca      120

gtaagagtgt cagtaccagc ggatactcct acatgcactg gtatcagcag aaaccaggac      180

aacctcctaa actcctgatt tacctggcat ccaatctgga gagcggggtc ccagccaggt      240

tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg gaagctaatg      300

atactgcaaa ttattactgt cagcacagta gggagctgcc tttcacattc ggcggaggga      360

ccaaggtgga gatcaaacga actggtcagc ccaaggctgc cccctcggtc actctgttcc      420

cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc ataagtgact      480

tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc aaggcgggag      540

tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc agctatctga      600

gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc acgcatgaag      660

ggagcaccgt ggagaagaca gtggccccta cagaatgttc atagtaagtt taaacccgct      720

gatcagcctc gactgtgcct tctagttg                                         748


<210>  220
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSEC Tag2 5' overlapping sequence

<400>  220
tgctctgggt tccaggttcc actggtgacg c                                      31


<210>  221
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSEC Tag2 3' overlapping sequence

<400>  221
ccgctgatca gcctcgactg tgccttctag ttg                                    33


<210>  222
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine Ig kappa chain leader sequence

<400>  222
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gac                                                                     63


<210>  223
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine Ig kappa chain leader sequence

<400>  223

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp 
            20      


<210>  224
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Interleukin-2 (IL-2) leader sequence

<400>  224
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60


<210>  225
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Interleukin-2 (IL-2) leader sequence

<400>  225

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  226
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 leader sequence

<400>  226
atgcctcttc tgcttctgct tcctctgctt tgggctggag ctcttgct                    48


<210>  227
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 leader sequence

<400>  227

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210>  228
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*03 leader sequence

<400>  228
atggaactgg ggctccgctg ggttttcctt gttgctattt tagaaggtgt ccagtgt          57


<210>  229
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*03 leader sequence

<400>  229

Met Glu Leu Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  230
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-11*02 leader sequence

<400>  230
atggaagccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccactgga       60


<210>  231
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-11*02 leader sequence

<400>  231

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  232
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 single chain GS3

<400>  232
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa caccctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagcggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgaaattgtg      420

ttgacacagt ctccagccac cctgtctttg tctccagggg aaagagccac cctcacctgc      480

agcgccacca gcagtgttag ctacatccac tggtaccaac agaggcctgg ccagagcccc      540

aggctcctca tctatagcac ctccaacctg gccagcggca tcccagccag gttcagtggc      600

agtgggtctg ggagcgacta cactctcacc atcagcagcc tagagcctga agattttgca      660

gtttattact gtcagcagcg tagcagctcc cctttcacct ttggcagcgg caccaaagtg      720

gaaattaaa                                                              729


<210>  233
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 single chain GS3

<400>  233

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro 
                165                 170                 175     


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  234
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 single chain IgG1noC

<400>  234
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa caccctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagcgata aaacccatac taaaccgcca aaaccggcgc cggaactgct gggtggtcct      420

ggtaccggtg aaattgtgtt gacacagtct ccagccaccc tgtctttgtc tccaggggaa      480

agagccaccc tcacctgcag cgccaccagc agtgttagct acatccactg gtaccaacag      540

aggcctggcc agagccccag gctcctcatc tatagcacct ccaacctggc cagcggcatc      600

ccagccaggt tcagtggcag tgggtctggg agcgactaca ctctcaccat cagcagccta      660

gagcctgaag attttgcagt ttattactgt cagcagcgta gcagctcccc tttcaccttt      720

ggcagcggca ccaaagtgga aattaaa                                          747


<210>  235
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 single chain IgG1noC

<400>  235

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Asp Lys Thr His Thr Lys 
        115                 120                 125             


Pro Pro Lys Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Glu 
    130                 135                 140                 


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
145                 150                 155                 160 


Arg Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His 
                165                 170                 175     


Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser 
            180                 185                 190         


Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
    210                 215                 220                 


Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe 
225                 230                 235                 240 


Gly Ser Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  236
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region)

<400>  236
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa caccctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagcgata aaacccatac taaaccgcca aaaccggcgc cggaactgct gggtggtcct      420

ggtaccggta ctggtggtcc gactattaaa cctccgaaac ctccgaaacc tgctccgaac      480

ctgctgggtg gtccggaaat tgtgttgaca cagtctccag ccaccctgtc tttgtctcca      540

ggggaaagag ccaccctcac ctgcagcgcc accagcagtg ttagctacat ccactggtac      600

caacagaggc ctggccagag ccccaggctc ctcatctata gcacctccaa cctggccagc      660

ggcatcccag ccaggttcag tggcagtggg tctgggagcg actacactct caccatcagc      720

agcctagagc ctgaagattt tgcagtttat tactgtcagc agcgtagcag ctcccctttc      780

acctttggca gcggcaccaa agtggaaatt aaa                                   813


<210>  237
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region)

<400>  237

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Asp Lys Thr His Thr Lys 
        115                 120                 125             


Pro Pro Lys Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Thr 
    130                 135                 140                 


Gly Gly Pro Thr Ile Lys Pro Pro Lys Pro Pro Lys Pro Ala Pro Asn 
145                 150                 155                 160 


Leu Leu Gly Gly Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
                165                 170                 175     


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys Ser Ala Thr Ser 
            180                 185                 190         


Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro 
        195                 200                 205             


Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser 
225                 230                 235                 240 


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
                245                 250                 255     


Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys 
            260                 265                 270     


<210>  238
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 single chain GS3

<400>  238
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaact                                          747


<210>  239
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 single chain GS3

<400>  239

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 


<210>  240
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 single chain IgG (no Cysteine)

<400>  240
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccgataaaa cccatactaa accgccaaaa ccggcgccgg aactgctggg tggtcctggt      420

accggtgaca ttgtgctgac ccagtctcca gcctccttgg ccgtgtctcc aggacagagg      480

gccaccatca cctgcagagc cagtaagagt gtcagtacca gcggatactc ctacatgcac      540

tggtatcagc agaaaccagg acaacctcct aaactcctga tttacctggc atccaatctg      600

gagagcgggg tcccagccag gttcagcggc agtgggtctg ggaccgattt caccctcaca      660

attaatcctg tggaagctaa tgatactgca aattattact gtcagcacag tagggagctg      720

cctttcacat tcggcggagg gaccaaggtg gagatcaaac gaact                      765


<210>  241
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 single chain IgG (no Cysteine)

<400>  241

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Asp Lys Thr His Thr Lys Pro 
        115                 120                 125             


Pro Lys Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Asp Ile 
    130                 135                 140                 


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg 
145                 150                 155                 160 


Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr 
                165                 170                 175     


Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
    210                 215                 220                 


Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu 
225                 230                 235                 240 


Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 250                 255 


<210>  242
<211>  831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region)

<400>  242
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccgataaaa cccatactaa accgccaaaa ccggcgccgg aactgctggg tggtcctggt      420

accggtactg gtggtccgac tattaaacct ccgaaacctc cgaaacctgc tccgaacctg      480

ctgggtggtc cggacattgt gctgacccag tctccagcct ccttggccgt gtctccagga      540

cagagggcca ccatcacctg cagagccagt aagagtgtca gtaccagcgg atactcctac      600

atgcactggt atcagcagaa accaggacaa cctcctaaac tcctgattta cctggcatcc      660

aatctggaga gcggggtccc agccaggttc agcggcagtg ggtctgggac cgatttcacc      720

ctcacaatta atcctgtgga agctaatgat actgcaaatt attactgtca gcacagtagg      780

gagctgcctt tcacattcgg cggagggacc aaggtggaga tcaaacgaac t               831


<210>  243
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region)

<400>  243

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Asp Lys Thr His Thr Lys Pro 
        115                 120                 125             


Pro Lys Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Thr Gly 
    130                 135                 140                 


Gly Pro Thr Ile Lys Pro Pro Lys Pro Pro Lys Pro Ala Pro Asn Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
                165                 170                 175     


Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser 
            180                 185                 190         


Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser 
    210                 215                 220                 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys 
                245                 250                 255     


Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr Lys Val 
            260                 265                 270         


Glu Ile Lys Arg Thr 
        275         


<210>  244
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 single chain GS3

<400>  244
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactacgcca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagtg atcagcacct tcagcggtaa cacaaacttc      180

aaccagaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaagcgac      300

tactacggcc catacttcga ctactggggc cagggcacca ccctgaccgt gtccagcggc      360

ggtggcggat ccggcggtgg cggatccggc ggtggcggat ccgatattgt gatgacccag      420

actccactct ctctgtccgt cacccctgga cagccggcct ccatctcctg caggtctagt      480

cagaccattg tccatagtaa tggaaacacc tatttggagt ggtacctgca gaagccaggc      540

cagtctccac agctcctgat ctataaggtt tccaaccggt tctctggagt gccagatagg      600

ttcagtggca gcgggtcagg gacagatttc acactgaaaa tcagccgggt ggaggctgag      660

gatgttgggg tttattactg cttccaaggt agccacgtgc ctttcacctt cggcggaggg      720

accaaggtgg agatcaaacg aact                                             744


<210>  245
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 single chain GS3

<400>  245

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 


Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Arg Thr 
                245             


<210>  246
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 single chain IgG1 (no Cysteine)

<400>  246
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactacgcca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagtg atcagcacct tcagcggtaa cacaaacttc      180

aaccagaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaagcgac      300

tactacggcc catacttcga ctactggggc cagggcacca ccctgaccgt gtccagcgat      360

aaaacccata ctaaaccgcc aaaaccggcg ccggaactgc tgggtggtcc tggtaccggt      420

gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc      480

atctcctgca ggtctagtca gaccattgtc catagtaatg gaaacaccta tttggagtgg      540

tacctgcaga agccaggcca gtctccacag ctcctgatct ataaggtttc caaccggttc      600

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      660

agccgggtgg aggctgagga tgttggggtt tattactgct tccaaggtag ccacgtgcct      720

ttcaccttcg gcggagggac caaggtggag atcaaacgaa ct                         762


<210>  247
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 single chain IgG1 (no Cysteine)

<400>  247

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Asp Lys Thr His Thr Lys Pro Pro Lys 
        115                 120                 125             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Asp Ile Val Met 
    130                 135                 140                 


Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser 
145                 150                 155                 160 


Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr 
                165                 170                 175     


Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
            180                 185                 190         


Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro 
225                 230                 235                 240 


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 250                 


<210>  248
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region)

<400>  248
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactacgcca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagtg atcagcacct tcagcggtaa cacaaacttc      180

aaccagaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaagcgac      300

tactacggcc catacttcga ctactggggc cagggcacca ccctgaccgt gtccagcgat      360

aaaacccata ctaaaccgcc aaaaccggcg ccggaactgc tgggtggtcc tggtaccggt      420

actggtggtc cgactattaa acctccgaaa cctccgaaac ctgctccgaa cctgctgggt      480

ggtccggata ttgtgatgac ccagactcca ctctctctgt ccgtcacccc tggacagccg      540

gcctccatct cctgcaggtc tagtcagacc attgtccata gtaatggaaa cacctatttg      600

gagtggtacc tgcagaagcc aggccagtct ccacagctcc tgatctataa ggtttccaac      660

cggttctctg gagtgccaga taggttcagt ggcagcgggt cagggacaga tttcacactg      720

aaaatcagcc gggtggaggc tgaggatgtt ggggtttatt actgcttcca aggtagccac      780

gtgcctttca ccttcggcgg agggaccaag gtggagatca aacgaact                   828


<210>  249
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region)

<400>  249

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Asp Lys Thr His Thr Lys Pro Pro Lys 
        115                 120                 125             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Thr Gly Gly Pro 
    130                 135                 140                 


Thr Ile Lys Pro Pro Lys Pro Pro Lys Pro Ala Pro Asn Leu Leu Gly 
145                 150                 155                 160 


Gly Pro Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr 
                165                 170                 175     


Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val 
            180                 185                 190         


His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly 
        195                 200                 205             


Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
    210                 215                 220                 


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
225                 230                 235                 240 


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe 
                245                 250                 255     


Gln Gly Ser His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu 
            260                 265                 270         


Ile Lys Arg Thr 
        275     


<210>  250
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 single chain GS3 (linker is [Gly4Ser1]3)

<400>  250
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cctgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagactgggc      300

ggcgataact attatgaata ttggggcaaa gggaccacgg tcaccgtctc ctccggcggt      360

ggcggatccg gcggtggcgg atccggcggt ggcggatccg acatcgtgat gacccagtct      420

ccagactccc tggctgtgtc tctgggcgag agggccacca tcaactgcag ggccagcaag      480

agtgttagca ccagcggcta cagctacatg cactggtacc agcagaaacc aggacagcct      540

cctaagctgc tcatttacct ggtgtctaac ctggaatccg gggtccctga ccgattcagt      600

ggcagcgggt ctgggacaga tttcactctc accatcagca gcctgcaggc tgaagatgtg      660

gcagtttatt actgtcaaca cattcgggaa ctgaccagga gtgaattcgg cggagggacc      720

aaggtggaga tcaaacgaac t                                                741


<210>  251
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 single chain GS3 (linker is [Gly4Ser1]3)

<400>  251

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu 
    130                 135                 140                 


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys 
145                 150                 155                 160 


Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln His Ile Arg Glu Leu Thr Arg Ser Glu Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Arg Thr 
                245         


<210>  252
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 single chain IgG1 (no Cysteine)

<400>  252
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cctgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagactgggc      300

ggcgataact attatgaata ttggggcaaa gggaccacgg tcaccgtctc ctccgataaa      360

acccatacta aaccgccaaa accggcgccg gaactgctgg gtggtcctgg taccggtgac      420

atcgtgatga cccagtctcc agactccctg gctgtgtctc tgggcgagag ggccaccatc      480

aactgcaggg ccagcaagag tgttagcacc agcggctaca gctacatgca ctggtaccag      540

cagaaaccag gacagcctcc taagctgctc atttacctgg tgtctaacct ggaatccggg      600

gtccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac catcagcagc      660

ctgcaggctg aagatgtggc agtttattac tgtcaacaca ttcgggaact gaccaggagt      720

gaattcggcg gagggaccaa ggtggagatc aaacgaact                             759


<210>  253
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 single chain IgG1 (no Cysteine)

<400>  253

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Asp Lys Thr His Thr Lys Pro Pro Lys Pro 
        115                 120                 125             


Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Asp Ile Val Met Thr 
    130                 135                 140                 


Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile 
145                 150                 155                 160 


Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met 
                165                 170                 175     


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Leu Val Ser Asn Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
    210                 215                 220                 


Asp Val Ala Val Tyr Tyr Cys Gln His Ile Arg Glu Leu Thr Arg Ser 
225                 230                 235                 240 


Glu Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 250             


<210>  254
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region)

<400>  254
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagactgggc      300

ggcgacaatt actatgagta ttggggcaaa gggaccacgg tcaccgtctc ctccgataaa      360

acccatacta aaccgccaaa accggcgccg gaactgctgg gtggtcctgg taccggtact      420

ggtggtccga ctattaaacc tccgaaacct ccgaaacctg ctccgaacct gctgggtggt      480

ccggacatcg tgatgaccca gtctccagac tccctggctg tgtctctggg cgagagggcc      540

accatcaact gcagggccag caagagtgtt agcaccagcg gctacagcta catgcactgg      600

taccagcaga aaccaggaca gcctcctaag ctgctcattt acctggtgtc taacctggaa      660

tccggggtcc ctgaccgatt cagtggcagc gggtctggga cagatttcac tctcaccatc      720

agcagcctgc aggctgaaga tgtggcagtt tattactgtc aacacattcg ggaactgacc      780

aggagtgaat tcggcggagg gaccaaggtg gagatcaaac gaact                      825


<210>  255
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region)

<400>  255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Asp Lys Thr His Thr Lys Pro Pro Lys Pro 
        115                 120                 125             


Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Thr Gly Gly Pro Thr 
    130                 135                 140                 


Ile Lys Pro Pro Lys Pro Pro Lys Pro Ala Pro Asn Leu Leu Gly Gly 
145                 150                 155                 160 


Pro Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
                165                 170                 175     


Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr 
            180                 185                 190         


Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        195                 200                 205             


Pro Lys Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro 
    210                 215                 220                 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
225                 230                 235                 240 


Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ile 
                245                 250                 255     


Arg Glu Leu Thr Arg Ser Glu Phe Gly Gly Gly Thr Lys Val Glu Ile 
            260                 265                 270         


Lys Arg Thr 
        275 


<210>  256
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSECTag2 E6 scFV-FC

<400>  256
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacgcggccc agccggccga ggtgcagctg gtggagtctg ggggaggcct ggtcaagcct      120

ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag gtatggcatg      180

agctgggtcc gccaggctcc agggaagagg ctggagtggg tctcaaccat tagtggcgga      240

ggcacctaca tatactaccc agactcagtg aagggccgat tcaccatctc cagagacaac      300

gccaagaaca ccctgtatct gcaaatgaac agcctgagag ccgaggacac ggctgtgtat      360

tactgtacca gagataacta tggccgcaac tatgattatg gcatggatta ttggggccag      420

ggcaccctgg tgaccgtgag cagcggcggt ggcggatccg gcggtggcgg atccggcggt      480

ggcggatccg aaattgtgtt gacacagtct ccagccaccc tgtctttgtc tccaggggaa      540

agagccaccc tcacctgcag cgccaccagc agtgttagct acatccactg gtaccaacag      600

aggcctggcc agagccccag gctcctcatc tatagcacct ccaacctggc cagcggcatc      660

ccagccaggt tcagtggcag tgggtctggg agcgactaca ctctcaccat cagcagccta      720

gagcctgaag attttgcagt ttattactgt cagcagcgta gcagctcccc tttcaccttt      780

ggcagcggca ccaaagtgga aattaaagag cccaaatctt gtgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

aaatgataa                                                             1509


<210>  257
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pSECTag2 E6 scFV-FC

<400>  257

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly 
65                  70                  75                  80  


Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly 
        115                 120                 125             


Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
                165                 170                 175     


Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val 
            180                 185                 190         


Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu 
        195                 200                 205             


Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser 
                245                 250                 255     


Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        275                 280                 285             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly Lys 
            500     


<210>  258
<211>  496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 scFC-FC 1 gBLOCk sequence

<400>  258
tgctctgggt tccaggttcc actggtgacg cggcccagcc ggccgaggtg cagctggtgg       60

agtctggggg aggcctggtc aagcctgggg ggtccctgag actctcctgt gcagcctctg      120

gattcacctt cagtaggtat ggcatgagct gggtccgcca ggctccaggg aagaggctgg      180

agtgggtctc aaccattagt ggcggaggca cctacatata ctacccagac tcagtgaagg      240

gccgattcac catctccaga gacaacgcca agaacaccct gtatctgcaa atgaacagcc      300

tgagagccga ggacacggct gtgtattact gtaccagaga taactatggc cgcaactatg      360

attatggcat ggattattgg ggccagggca ccctggtgac cgtgagcagc ggcggtggcg      420

gatccggcgg tggcggatcc ggcggtggcg gatccgaaat tgtgttgaca cagtctccag      480

ccaccctgtc tttgtc                                                      496


<210>  259
<211>  583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 scFC-FC 2 gBLOCk sequence

<400>  259
aattgtgttg acacagtctc cagccaccct gtctttgtct ccaggggaaa gagccaccct       60

cacctgcagc gccaccagca gtgttagcta catccactgg taccaacaga ggcctggcca      120

gagccccagg ctcctcatct atagcacctc caacctggcc agcggcatcc cagccaggtt      180

cagtggcagt gggtctggga gcgactacac tctcaccatc agcagcctag agcctgaaga      240

ttttgcagtt tattactgtc agcagcgtag cagctcccct ttcacctttg gcagcggcac      300

caaagtggaa attaaagagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc      360

agcacctgaa ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac      420

cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga      480

ccctgaggtc aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa      540

gccgcgggag gagcagtaca acagcacgta ccgtgtggtc agc                        583


<210>  260
<211>  1527
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSECTag2 C2 scFV-FC

<400>  260
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacgcggccc agccggccga ggtgcagctg gtggagtctg ggggaggcct ggtcaagcct      120

ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtgg ctatgccatg      180

agctgggtcc gccaggctcc agggaagggg ctggagtggg tctcaaccat tagtagtggc      240

ggaacctaca tatactaccc cgactcagtg aagggccgat tcaccatctc cagagacaac      300

gccaagaact cactgtatct gcaaatgaac agcctgagag ccgaggacac ggccgtgtat      360

tactgtgcga gacttggggg ggataattac tacgaatact tcgatgtctg gggcaaaggg      420

accacggtca ccgtctcctc cggcggtggc ggatccggcg gtggcggatc cggcggtggc      480

ggatccgaca ttgtgctgac ccagtctcca gcctccttgg ccgtgtctcc aggacagagg      540

gccaccatca cctgcagagc cagtaagagt gtcagtacca gcggatactc ctacatgcac      600

tggtatcagc agaaaccagg acaacctcct aaactcctga tttacctggc atccaatctg      660

gagagcgggg tcccagccag gttcagcggc agtgggtctg ggaccgattt caccctcaca      720

attaatcctg tggaagctaa tgatactgca aattattact gtcagcacag tagggagctg      780

cctttcacat tcggcggagg gaccaaggtg gagatcaaac gaactgagcc caaatcttgt      840

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      900

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      960

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     1020

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     1080

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1140

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1200

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1260

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1320

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1380

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1440

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1500

ctctccctgt ctccgggtaa atgataa                                         1527


<210>  261
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pSECTag2 C2 scFV-FC

<400>  261

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly 
65                  70                  75                  80  


Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp 
        115                 120                 125             


Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
                165                 170                 175     


Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser 
            180                 185                 190         


Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln 
        195                 200                 205             


Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val 
    210                 215                 220                 


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
225                 230                 235                 240 


Ile Asn Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His 
                245                 250                 255     


Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            260                 265                 270         


Lys Arg Thr Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        275                 280                 285             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    290                 295                 300                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
305                 310                 315                 320 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                325                 330                 335     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            340                 345                 350         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        355                 360                 365             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    370                 375                 380                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
385                 390                 395                 400 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                405                 410                 415     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            420                 425                 430         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        435                 440                 445             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    450                 455                 460                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
465                 470                 475                 480 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                485                 490                 495     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505         


<210>  262
<211>  487
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 scFV-FC 1 gBLOCk sequence

<400>  262
tgctctgggt tccaggttcc actggtgacg cggcccagcc ggccgaggtg cagctggtgg       60

agtctggggg aggcctggtc aagcctgggg ggtccctgag actctcctgt gcagcctctg      120

gattcacctt cagtggctat gccatgagct gggtccgcca ggctccaggg aaggggctgg      180

agtgggtctc aaccattagt agtggcggaa cctacatata ctaccccgac tcagtgaagg      240

gccgattcac catctccaga gacaacgcca agaactcact gtatctgcaa atgaacagcc      300

tgagagccga ggacacggcc gtgtattact gtgcgagact tgggggggat aattactacg      360

aatacttcga tgtctggggc aaagggacca cggtcaccgt ctcctccggc ggtggcggat      420

ccggcggtgg cggatccggc ggtggcggat ccgacattgt gctgacccag tctccagcct      480

ccttggc                                                                487


<210>  263
<211>  604
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 scFV-FC 2 gBLOCk sequence

<400>  263
cattgtgctg acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat       60

cacctgcaga gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca      120

gcagaaacca ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg      180

ggtcccagcc aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc      240

tgtggaagct aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac      300

attcggcgga gggaccaagg tggagatcaa acgaactgag cccaaatctt gtgacaaaac      360

tcacacatgc ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt      420

ccccccaaaa cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt      480

ggtggacgtg agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga      540

ggtgcataat gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt      600

cagc                                                                   604


<210>  264
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSECTag2 C3 scFV-FC

<400>  264
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacgcggccc agccggccca ggttcagctg gtgcagtctg gagctgaggt gaagaagcct      120

ggggcctcag tgaaggtctc ctgcaaggct tctggttaca cctttaccga ctacgccatg      180

aactgggtgc gacaggcccc tggacaaggg cttgagtgga tgggagtgat cagcaccttc      240

agcggtaaca caaacttcaa ccagaagttc aagggcagag tcaccatgac cacagacaca      300

tccacgagca cagcctacat ggagctgagg agcctgagat ctgacgacac ggccgtgtat      360

tactgtgcga gaagcgacta ctacggccca tacttcgact actggggcca gggcaccacc      420

ctgaccgtgt ccagcggcgg tggcggatcc ggcggtggcg gatccggcgg tggcggatcc      480

gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc      540

atctcctgca ggtctagtca gaccattgtc catagtaatg gaaacaccta tttggagtgg      600

tacctgcaga agccaggcca gtctccacag ctcctgatct ataaggtttc caaccggttc      660

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      720

agccgggtgg aggctgagga tgttggggtt tattactgct tccaaggtag ccacgtgcct      780

ttcaccttcg gcggagggac caaggtggag atcaaacgaa ctgagcccaa atcttgtgac      840

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      900

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      960

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     1020

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     1080

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1140

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1200

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac     1260

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1320

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1380

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1440

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1500

tccctgtctc cgggtaaatg ataa                                            1524


<210>  265
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pSECTag2 C3 scFV-FC

<400>  265

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Gln Val Gln Leu Val Gln 
            20                  25                  30          


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
        35                  40                  45              


Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Ala Met Asn Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Val Ile Ser Thr Phe 
65                  70                  75                  80  


Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe Lys Gly Arg Val Thr Met 
                85                  90                  95      


Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu 
            100                 105                 110         


Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Tyr Tyr 
        115                 120                 125             


Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
                165                 170                 175     


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            180                 185                 190         


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        195                 200                 205             


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    210                 215                 220                 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
225                 230                 235                 240 


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                245                 250                 255     


Ser His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            260                 265                 270         


Arg Thr Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
        275                 280                 285             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    290                 295                 300                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
305                 310                 315                 320 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                325                 330                 335     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            340                 345                 350         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        355                 360                 365             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    370                 375                 380                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
385                 390                 395                 400 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
                405                 410                 415     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            420                 425                 430         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        435                 440                 445             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    450                 455                 460                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
465                 470                 475                 480 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                485                 490                 495     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505     


<210>  266
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C3 GS scFV FC 1 gBLOCk sequence

<400>  266
tgctctgggt tccaggttcc actggtgacg cggcccagcc ggcccaggtt cagctggtgc       60

agtctggagc tgaggtgaag aagcctgggg cctcagtgaa ggtctcctgc aaggcttctg      120

gttacacctt taccgactac gccatgaact gggtgcgaca ggcccctgga caagggcttg      180

agtggatggg agtgatcagc accttcagcg gtaacacaaa cttcaaccag aagttcaagg      240

gcagagtcac catgaccaca gacacatcca cgagcacagc ctacatggag ctgaggagcc      300

tgagatctga cgacacggcc gtgtattact gtgcgagaag cgactactac ggcccatact      360

tcgactactg gggccagggc accaccctga ccgtgtccag cggcggtggc ggatccggcg      420

gtggcggatc cggcggtggc ggatccgata ttgtgatgac ccagactcca ctctctctgt      480


<210>  267
<211>  607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C3 scFV FC2 gBLOCk sequence

<400>  267
tattgtgatg acccagactc cactctctct gtccgtcacc cctggacagc cggcctccat       60

ctcctgcagg tctagtcaga ccattgtcca tagtaatgga aacacctatt tggagtggta      120

cctgcagaag ccaggccagt ctccacagct cctgatctat aaggtttcca accggttctc      180

tggagtgcca gataggttca gtggcagcgg gtcagggaca gatttcacac tgaaaatcag      240

ccgggtggag gctgaggatg ttggggttta ttactgcttc caaggtagcc acgtgccttt      300

caccttcggc ggagggacca aggtggagat caaacgaact gagcccaaat cttgtgacaa      360

aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct      420

cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt      480

ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt      540

ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt      600

ggtcagc                                                                607


<210>  268
<211>  1521
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSECTag2 C8 scFV-FC

<400>  268
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacgcggccc agccggccga ggtgcagctg gtggagtctg ggggaggcct ggtcaagcct      120

ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtgg ctatgccatg      180

agctgggtcc gccaggctcc agggaagggg ctggagtggg tctcaaccat tagtagtggc      240

ggaacctaca tatactaccc tgactcagtg aagggccgat tcaccatctc cagagacaac      300

gccaagaact cactgtatct gcaaatgaac agcctgagag ccgaggacac ggccgtgtat      360

tactgtgcga gactgggcgg cgataactat tatgaatatt ggggcaaagg gaccacggtc      420

accgtctcct ccggcggtgg cggatccggc ggtggcggat ccggcggtgg cggatccgac      480

atcgtgatga cccagtctcc agactccctg gctgtgtctc tgggcgagag ggccaccatc      540

aactgcaggg ccagcaagag tgttagcacc agcggctaca gctacatgca ctggtaccag      600

cagaaaccag gacagcctcc taagctgctc atttacctgg tgtctaacct ggaatccggg      660

gtccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac catcagcagc      720

ctgcaggctg aagatgtggc agtttattac tgtcaacaca ttcgggaact gaccaggagt      780

gaattcggcg gagggaccaa ggtggagatc aaacgaactg agcccaaatc ttgtgacaaa      840

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      900

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      960

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1020

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1080

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1140

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1200

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1260

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1320

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1380

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1440

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1500

ctgtctccgg gtaaatgata a                                               1521


<210>  269
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pSECTag2 C8 scFV-FC

<400>  269

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly 
65                  70                  75                  80  


Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp 
        115                 120                 125             


Asn Tyr Tyr Glu Tyr Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu 
                165                 170                 175     


Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly 
            180                 185                 190         


Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ile Arg Glu 
                245                 250                 255     


Leu Thr Arg Ser Glu Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            260                 265                 270         


Thr Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        275                 280                 285             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    290                 295                 300                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
305                 310                 315                 320 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                325                 330                 335     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            340                 345                 350         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        355                 360                 365             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    370                 375                 380                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
385                 390                 395                 400 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                405                 410                 415     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            420                 425                 430         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        435                 440                 445             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    450                 455                 460                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
465                 470                 475                 480 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                485                 490                 495     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505 


<210>  270
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C8 scFV FC 1 gBLOCk sequence

<400>  270
tgctctgggt tccaggttcc actggtgacg cggcccagcc ggccgaggtg cagctggtgg       60

agtctggggg aggcctggtc aagcctgggg ggtccctgag actctcctgt gcagcctctg      120

gattcacctt cagtggctat gccatgagct gggtccgcca ggctccaggg aaggggctgg      180

agtgggtctc aaccattagt agtggcggaa cctacatata ctaccctgac tcagtgaagg      240

gccgattcac catctccaga gacaacgcca agaactcact gtatctgcaa atgaacagcc      300

tgagagccga ggacacggcc gtgtattact gtgcgagact gggcggcgat aactattatg      360

aatattgggg caaagggacc acggtcaccg tctcctccgg cggtggcgga tccggcggtg      420

gcggatccgg cggtggcgga tccgacatcg tgatgaccca gtctccagac tccctgg         477


<210>  271
<211>  607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C8 scFV FC2 gBLOCk sequence

<400>  271
catcgtgatg acccagtctc cagactccct ggctgtgtct ctgggcgaga gggccaccat       60

caactgcagg gccagcaaga gtgttagcac cagcggctac agctacatgc actggtacca      120

gcagaaacca ggacagcctc ctaagctgct catttacctg gtgtctaacc tggaatccgg      180

ggtccctgac cgattcagtg gcagcgggtc tgggacagat ttcactctca ccatcagcag      240

cctgcaggct gaagatgtgg cagtttatta ctgtcaacac attcgggaac tgaccaggag      300

tgaattcggc ggagggacca aggtggagat caaacgaact gagcccaaat cttgtgacaa      360

aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct      420

cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt      480

ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt      540

ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt      600

ggtcagc                                                                607


<210>  272
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc sequence

<400>  272
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaatgat aa                         702


<210>  273
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc sequence

<400>  273

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  274
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH2-CH3 domain sequence

<400>  274
ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc       60

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      120

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      180

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc      240

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      300

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag      360

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc      420

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg      480

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac      540

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg      600

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa      660

tgataa                                                                 666


<210>  275
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH2-CH3 domain sequence

<400>  275

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        115                 120                 125             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    130                 135                 140                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                165                 170                 175     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220 


<210>  276
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH3 domain sequence

<400>  276
gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag       60

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      120

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      180

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      240

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      300

ctctccctgt ctccgggtaa atgataa                                          327


<210>  277
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH3 domain sequence

<400>  277

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  278
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc Y407R sequence

<400>  278
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctcaggagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaatgat aa                         702


<210>  279
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc Y407R sequence

<400>  279

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Arg 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  280
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc F405Q sequence

<400>  280
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttccag ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaatgat aa                         702


<210>  281
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc F405Q sequence

<400>  281

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Gln Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  282
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc T394D sequence

<400>  282
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccgaccct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaatgat aa                         702


<210>  283
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc T394D sequence

<400>  283

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Asp Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  284
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc T366W/L368W sequence

<400>  284
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcagcctg tggtgctggg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaatgat aa                         702


<210>  285
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc T366W/L368W sequence

<400>  285

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Trp Cys Trp Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  286
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc T364R/L368R sequence

<400>  286
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcaggctg acctgcaggg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaatgat aa                         702


<210>  287
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc T364R/L368R sequence

<400>  287

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Arg Leu Thr Cys Arg Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  288
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc hingeless sequence

<400>  288
gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc       60

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      120

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      180

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      240

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc      300

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc      360

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa      420

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac      480

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc      540

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag      600

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atgataa         657


<210>  289
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc hingeless sequence

<400>  289

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  290
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 G237A FC sequence

<400>  290
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

ggggccccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaa                                696


<210>  291
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 G237A FC sequence

<400>  291

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  292
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 L234A/L235A FC sequence

<400>  292
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcc       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaa                                696


<210>  293
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 L234A/L235A FC sequence

<400>  293

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  294
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD3z sequence

<400>  294
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aaacgacaac cccggccccc agaccaccaa cgccagcccc caccatcgcc      840

agccaacccc tgtctctgag accagaagcc tgtaggcctg ccgccggtgg agctgtgcac      900

acaagaggac tggatttcgc ctgtgatatc tacatttggg ccccgctcgc aggcacatgt      960

ggagtgctcc tcctctccct ggtgattacc ctgtactgcc gcgttaagtt ctcccgatca     1020

gccgacgcgc ctgcttacaa gcagggccag aaccaactgt acaacgagct gaatctcggt     1080

agacgggaag agtacgacgt gttggacaaa cggagaggcc gcgacccaga aatgggcggc     1140

aagcctcgca ggaaaaaccc ccaggaggga ctgtacaatg agttgcagaa agataagatg     1200

gcagaagctt atagcgagat cggaatgaag ggggaaagga gacgagggaa aggacacgac     1260

ggcctttatc agggcctgtc cacagcaaca aaagatacgt atgacgccct ccatatgcag     1320

gcacttccac cacggtgata a                                               1341


<210>  295
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD3z sequence

<400>  295

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Val Lys 
                325                 330                 335     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
            340                 345                 350         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        355                 360                 365             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
    370                 375                 380                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
385                 390                 395                 400 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                405                 410                 415     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            420                 425                 430         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445 


<210>  296
<211>  485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD3z gBLOCK sequence

<400>  296
tggagctgtg cacacaagag gactggattt cgcctgtgat atctacattt gggccccgct       60

cgcaggcaca tgtggagtgc tcctcctctc cctggtgatt accctgtact gccgcgttaa      120

gttctcccga tcagccgacg cgcctgctta caagcagggc cagaaccaac tgtacaacga      180

gctgaatctc ggtagacggg aagagtacga cgtgttggac aaacggagag gccgcgaccc      240

agaaatgggc ggcaagcctc gcaggaaaaa cccccaggag ggactgtaca atgagttgca      300

gaaagataag atggcagaag cttatagcga gatcggaatg aagggggaaa ggagacgagg      360

gaaaggacac gacggccttt atcagggcct gtccacagca acaaaagata cgtatgacgc      420

cctccatatg caggcacttc caccacggtg ataagtttaa acccgctgat cagcctcgac      480

tgtgc                                                                  485


<210>  297
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD28/CD3z sequence

<400>  297
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aaacgacaac cccggccccc agaccaccaa cgccagcccc caccatcgcc      840

agccaacccc tgtctctgag accagaagcc tgtaggcctg ccgccggtgg agctgtgcac      900

acaagaggac tggatttcgc ctgtgatatc tacatttggg ccccgctcgc aggcacatgt      960

ggagtgctcc tcctctccct ggtgattacc ctgtactgca gaagcaagcg gtctcggctc     1020

ctgcattctg attacatgaa catgacccca agaagaccag gccccaccag gaaacattac     1080

cagccctacg ctccgccacg cgacttcgct gcctaccggt cccgcgttaa gttctcccga     1140

tcagccgacg cgcctgctta caagcagggc cagaaccaac tgtacaacga gctgaatctc     1200

ggtagacggg aagagtacga cgtgttggac aaacggagag gccgcgaccc agaaatgggc     1260

ggcaagcctc gcaggaaaaa cccccaggag ggactgtaca atgagttgca gaaagataag     1320

atggcagaag cttatagcga gatcggaatg aagggggaaa ggagacgagg gaaaggacac     1380

gacggccttt atcagggcct gtccacagca acaaaagata cgtatgacgc cctccatatg     1440

caggcacttc caccacggtg ataa                                            1464


<210>  298
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD28/CD3z sequence

<400>  298

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  299
<211>  608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD28/CD3z g BLOCK sequence

<400>  299
tggagctgtg cacacaagag gactggattt cgcctgtgat atctacattt gggccccgct       60

cgcaggcaca tgtggagtgc tcctcctctc cctggtgatt accctgtact gcagaagcaa      120

gcggtctcgg ctcctgcatt ctgattacat gaacatgacc ccaagaagac caggccccac      180

caggaaacat taccagccct acgctccgcc acgcgacttc gctgcctacc ggtcccgcgt      240

taagttctcc cgatcagccg acgcgcctgc ttacaagcag ggccagaacc aactgtacaa      300

cgagctgaat ctcggtagac gggaagagta cgacgtgttg gacaaacgga gaggccgcga      360

cccagaaatg ggcggcaagc ctcgcaggaa aaacccccag gagggactgt acaatgagtt      420

gcagaaagat aagatggcag aagcttatag cgagatcgga atgaaggggg aaaggagacg      480

agggaaagga cacgacggcc tttatcaggg cctgtccaca gcaacaaaag atacgtatga      540

cgccctccat atgcaggcac ttccaccacg gtgataagtt taaacccgct gatcagcctc      600

gactgtgc                                                               608


<210>  300
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 4-1BB/CD3z sequence

<400>  300
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aaacgacaac cccggccccc agaccaccaa cgccagcccc caccatcgcc      840

agccaacccc tgtctctgag accagaagcc tgtaggcctg ccgccggtgg agctgtgcac      900

acaagaggac tggatttcgc ctgtgatatc tacatttggg ccccgctcgc aggcacatgt      960

ggagtgctcc tcctctccct ggtgattacc ctgtactgca aaaggggccg caaaaaactc     1020

ctttacattt ttaagcagcc ttttatgagg ccagtacaga cgactcaaga ggaagacggg     1080

tgctcatgcc gctttcctga ggaggaggaa ggagggtgcg aactgcgcgt taagttctcc     1140

cgatcagccg acgcgcctgc ttacaagcag ggccagaacc aactgtacaa cgagctgaat     1200

ctcggtagac gggaagagta cgacgtgttg gacaaacgga gaggccgcga cccagaaatg     1260

ggcggcaagc ctcgcaggaa aaacccccag gagggactgt acaatgagtt gcagaaagat     1320

aagatggcag aagcttatag cgagatcgga atgaaggggg aaaggagacg agggaaagga     1380

cacgacggcc tttatcaggg cctgtccaca gcaacaaaag atacgtatga cgccctccat     1440

atgcaggcac ttccaccacg gtgataa                                         1467


<210>  301
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 4-1BB/CD3z sequence

<400>  301

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  302
<211>  611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 4-1BB/CD3z gBLOCK sequence

<400>  302
tggagctgtg cacacaagag gactggattt cgcctgtgat atctacattt gggccccgct       60

cgcaggcaca tgtggagtgc tcctcctctc cctggtgatt accctgtact gcaaaagggg      120

ccgcaaaaaa ctcctttaca tttttaagca gccttttatg aggccagtac agacgactca      180

agaggaagac gggtgctcat gccgctttcc tgaggaggag gaaggagggt gcgaactgcg      240

cgttaagttc tcccgatcag ccgacgcgcc tgcttacaag cagggccaga accaactgta      300

caacgagctg aatctcggta gacgggaaga gtacgacgtg ttggacaaac ggagaggccg      360

cgacccagaa atgggcggca agcctcgcag gaaaaacccc caggagggac tgtacaatga      420

gttgcagaaa gataagatgg cagaagctta tagcgagatc ggaatgaagg gggaaaggag      480

acgagggaaa ggacacgacg gcctttatca gggcctgtcc acagcaacaa aagatacgta      540

tgacgccctc catatgcagg cacttccacc acggtgataa gtttaaaccc gctgatcagc      600

ctcgactgtg c                                                           611


<210>  303
<211>  1590
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD28/4-1BB/CD3z sequence

<400>  303
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aaacgacaac cccggccccc agaccaccaa cgccagcccc caccatcgcc      840

agccaacccc tgtctctgag accagaagcc tgtaggcctg ccgccggtgg agctgtgcac      900

acaagaggac tggatttcgc ctgtgatatc tacatttggg ccccgctcgc aggcacatgt      960

ggagtgctcc tcctctccct ggtgattacc ctgtactgca gaagcaagcg gtctcggctc     1020

ctgcattctg attacatgaa catgacccca agaagaccag gccccaccag gaaacattac     1080

cagccctacg ctccgccacg cgacttcgct gcctaccggt ccaaaagggg ccgcaaaaaa     1140

ctcctttaca tttttaagca gccttttatg aggccagtac agacgactca agaggaagac     1200

gggtgctcat gccgctttcc tgaggaggag gaaggagggt gcgaactgcg cgttaagttc     1260

tcccgatcag ccgacgcgcc tgcttacaag cagggccaga accaactgta caacgagctg     1320

aatctcggta gacgggaaga gtacgacgtg ttggacaaac ggagaggccg cgacccagaa     1380

atgggcggca agcctcgcag gaaaaacccc caggagggac tgtacaatga gttgcagaaa     1440

gataagatgg cagaagctta tagcgagatc ggaatgaagg gggaaaggag acgagggaaa     1500

ggacacgacg gcctttatca gggcctgtcc acagcaacaa aagatacgta tgacgccctc     1560

catatgcagg cacttccacc acggtgataa                                      1590


<210>  304
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD28/4-1BB/CD3z sequence

<400>  304

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    370                 375                 380                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
385                 390                 395                 400 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                405                 410                 415     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            420                 425                 430         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        435                 440                 445             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    450                 455                 460                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
465                 470                 475                 480 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                485                 490                 495     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            500                 505                 510         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520                 525             


<210>  305
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD28/4-1BB/CD3z gBLOCK sequence

<400>  305
atagggagac ccaagctggc tagttaagct tggtaccgag ggccaccatg gccctgcccg       60

tgaccgcttt gctgctcccc ctggcgctgc tgctgcacgc cgccaggcca gaggtccagc      120

tggttgagag tggcggtggg ctggttaagc ctggcggctc cctgcggctg agctgcgccg      180

cgagtggatt tactttcagc cgatatggga tgagttgggt gcggcaagct cccgggaaga      240

ggctggaatg ggtctcaaca atctccgggg ggggcactta catctattac cccgactcag      300

tcaaggggag atttaccatt tcacgagaca acgctaagaa taccctgtat ttgcagatga      360

attctctgag agcagaggac acagctgttt actattgtac ccgcgacaac tatggcagga      420

actacgacta cggtatggac tattggggac aagggacatt ggttacagtg agcagtggcg      480

gcgggggcag cggaggagga ggcagcggtg gggggggcag cgagatagtg ctcacgcagt      540

cacccgcgac tctcagtctc tcacctgggg aacgagctac cctgacgtgc tctgctacct      600

cctcagtgtc atatattcac tggtatcagc aacggcccgg gcagtcccct agattgctca      660

tttatagtac ctctaatctg gcctcaggta tccctgcacg attttctgga tctggttcag      720

gttctgatta caccctcact atctctagcc tggagcctga agactttgcc gtttattact      780

gccagcagag gtctagctcc ccattcacct ttgggagtgg gaccaaggtt gaaattaaaa      840

cgacaacccc ggcccccaga ccaccaacgc cagcccccac catcgccagc caacccctgt      900

ctctgagacc agaagcctgt aggcctgccg ccggtggagc tgtgcacaca agaggactgg      960

atttcgcctg tgatatctac atttgggccc cgctcgcagg cacatgtgga gtgctcctcc     1020

tctccctggt gattaccctg tactgcagaa gcaagcggtc tcggctcctg cattctgatt     1080

acatgaacat gaccccaaga agaccaggcc ccaccaggaa acattaccag ccctacgctc     1140

cgccacgcga cttcgctgcc taccggtcca aaaggggccg caaaaaactc ctttacattt     1200

ttaagcagcc ttttatgagg ccagtacaga cgactcaaga ggaagacggg tgctcatgcc     1260

gctttcctga ggaggaggaa ggagggtgcg aactgcgcgt taagttctcc cgatcagccg     1320

acgcgcctgc ttacaagcag ggccagaacc aactgtacaa cgagctgaat ctcggtagac     1380

gggaagagta cgacgtgttg gacaaacgga gaggccgcga cccagaaatg ggcggcaagc     1440

ctcgcaggaa aaacccccag gagggactgt acaatgagtt gcagaaagat aagatggcag     1500

aagcttatag cgagatcgga atgaaggggg aaaggagacg agggaaagga cacgacggcc     1560

tttatcaggg cctgtccaca gcaacaaaag atacgtatga cgccctccat atgcaggcac     1620

ttccaccacg gtgataagtt taaacccgct gatcagcctc gactgtgc                  1668


<210>  306
<211>  1608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD28/4-1BB/CD3z sequence

<400>  306
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc acgacaaccc cggcccccag accaccaacg      840

ccagccccca ccatcgccag ccaacccctg tctctgagac cagaagcctg taggcctgcc      900

gccggtggag ctgtgcacac aagaggactg gatttcgcct gtgatatcta catttgggcc      960

ccgctcgcag gcacatgtgg agtgctcctc ctctccctgg tgattaccct gtactgcaga     1020

agcaagcggt ctcggctcct gcattctgat tacatgaaca tgaccccaag aagaccaggc     1080

cccaccagga aacattacca gccctacgct ccgccacgcg acttcgctgc ctaccggtcc     1140

aaaaggggcc gcaaaaaact cctttacatt tttaagcagc cttttatgag gccagtacag     1200

acgactcaag aggaagacgg gtgctcatgc cgctttcctg aggaggagga aggagggtgc     1260

gaactgcgcg ttaagttctc ccgatcagcc gacgcgcctg cttacaagca gggccagaac     1320

caactgtaca acgagctgaa tctcggtaga cgggaagagt acgacgtgtt ggacaaacgg     1380

agaggccgcg acccagaaat gggcggcaag cctcgcagga aaaaccccca ggagggactg     1440

tacaatgagt tgcagaaaga taagatggca gaagcttata gcgagatcgg aatgaagggg     1500

gaaaggagac gagggaaagg acacgacggc ctttatcagg gcctgtccac agcaacaaaa     1560

gatacgtatg acgccctcca tatgcaggca cttccaccac ggtgataa                  1608


<210>  307
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD28/4-1BB/CD3z sequence

<400>  307

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Thr Pro Ala Pro Arg 
                245                 250                 255     


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
            260                 265                 270         


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
        275                 280                 285             


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
    290                 295                 300                 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        355                 360                 365             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    370                 375                 380                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
385                 390                 395                 400 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                405                 410                 415     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            420                 425                 430         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        435                 440                 445             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    450                 455                 460                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
465                 470                 475                 480 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                485                 490                 495     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            500                 505                 510         


Arg 
    


<210>  308
<211>  553
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2-1 gBLOCK sequence

<400>  308
atagggagac ccaagctggc tagttaagct tggtaccgag ggccaccatg gccttgccag       60

tgacggccct gctgctgcca ttggctcttc tgttgcacgc tgccaggcct gaagtgcagc      120

tcgtagagag tggcggggga ctggtgaagc ccggtggaag cctcagactc agttgcgccg      180

cctcaggttt cactttttca ggttacgcca tgtcctgggt aagacaggca ccggggaaag      240

gactcgagtg ggtgtctact atcagctcag gaggcactta tatatattat cctgactctg      300

taaaaggccg atttacgatt tctcgcgaca atgcaaagaa ctccctctac ctccaaatga      360

acagtcttag ggcagaagac actgctgtat actattgtgc acgcctcggc ggcgacaact      420

actacgagta ctttgacgtg tgggggaaag ggactaccgt gacagtttca agcggaggag      480

gtggctcagg tggaggcggg tcaggggggg gaggaagtga tattgtgctc acacaatccc      540

cagcctccct ggc                                                         553


<210>  309
<211>  518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2-2 gBLOCK sequence

<400>  309
aagtgatatt gtgctcacac aatccccagc ctccctggct gtgtctcccg gccaacgcgc       60

tacaattaca tgtcgggcct ccaaaagcgt gagcaccagc ggctacagct acatgcactg      120

gtatcaacag aaaccaggac aaccccccaa actgttgatt tatctcgctt caaacttgga      180

gtccggcgtg cctgcgcgct tttcagggag tgggagcggc acagatttta cgctgactat      240

caaccccgta gaagcaaacg atacagcgaa ttattattgt caacattccc gggaactccc      300

ctttacgttc ggcgggggca caaaggtcga aattaagaga accacgacaa ccccggcccc      360

cagaccacca acgccagccc ccaccatcgc cagccaaccc ctgtctctga gaccagaagc      420

ctgtaggcct gccgccggtg gagctgtgca cacaagagga ctggatttcg cctgtgatat      480

ctacatttgg gccccgctcg caggcacatg tggagtgc                              518


<210>  310
<211>  2028
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR E6 Fc/8/4-1BB/CD3z sequence

<400>  310
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtggcggagg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aagagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      840

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      900

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      960

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg     1020

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1080

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1140

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1200

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1260

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1320

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1380

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1440

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaaat ctacatttgg     1500

gccccgctcg caggcacatg tggagtgctc ctcctctccc tggtgattac cctgtactgc     1560

aaaaggggcc gcaaaaaact cctttacatt tttaagcagc cttttatgag gccagtacag     1620

acgactcaag aggaagacgg gtgctcatgc cgctttcctg aggaggagga aggagggtgc     1680

gaactgcgcg ttaagttctc ccgatcagcc gacgcgcctg cttacaagca gggccagaac     1740

caactgtaca acgagctgaa tctcggtaga cgggaagagt acgacgtgtt ggacaaacgg     1800

agaggccgcg acccagaaat gggcggcaag cctcgcagga aaaaccccca ggagggactg     1860

tacaatgagt tgcagaaaga taagatggca gaagcttata gcgagatcgg aatgaagggg     1920

gaaaggagac gagggaaagg acacgacggc ctttatcagg gcctgtccac agcaacaaaa     1980

gatacgtatg acgccctcca tatgcaggca cttccaccac ggtgataa                  2028


<210>  311
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR E6 Fc/8/4-1BB/CD3z sequence

<400>  311

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr 
            260                 265                 270         


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
            500                 505                 510         


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
        515                 520                 525             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    530                 535                 540                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
545                 550                 555                 560 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
                565                 570                 575     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            580                 585                 590         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        595                 600                 605             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    610                 615                 620                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
625                 630                 635                 640 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                645                 650                 655     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            660                 665                 670         


Pro Arg 
        


<210>  312
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 CAR pCDH gBLOCK sequence

<400>  312
acgctgtttt gacctccata gaagattcta gagctagctg tagagcttgg taccgagggc       60

caccatggcc ctgcccgtga ccgctttgct gctccccctg gcgctgctgc tgcacgccgc      120

caggccagag gtccagctgg ttgagagtgg cggtgggctg gttaagcctg gcggctccct      180

gcggctgagc tgcgccgcga gtggatttac tttcagccga tatgggatga gttgggtgcg      240

gcaagctccc gggaagaggc tggaatgggt ctcaacaatc tccggggggg gcacttacat      300

ctattacccc gactcagtca aggggagatt taccatttca cgagacaacg ctaagaatac      360

cctgtatttg cagatgaatt ctctgagagc agaggacaca gctgtttact attgtacccg      420

cgacaactat ggcaggaact acgactacgg tatggactat tggggacaag ggacattggt      480

tacagtgagc agtggcggcg ggggcagcgg aggaggaggc agcggtggcg gaggcagcga      540

gatagtgctc acgcagtcac ccgcgactct cagtctctca cctggggaac gagctaccct      600

gacgtgctct gctacctcct cagtgtcata tattcactgg tatcagcaac ggcccgggca      660

gtcccctaga ttgctcattt atagtacctc taatctggcc tcaggtatcc ctgc            714


<210>  313
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 CAR Fc pCDH gBLOCK sequence

<400>  313
agtacctcta atctggcctc aggtatccct gcacgatttt ctggatctgg ttcaggttct       60

gattacaccc tcactatctc tagcctggag cctgaagact ttgccgttta ttactgccag      120

cagaggtcta gctccccatt cacctttggg agtgggacca aggttgaaat taaagagccc      180

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      240

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      300

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      360

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      420

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      480

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      540

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      600

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      660

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      720

ctg                                                                    723


<210>  314
<211>  778
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 CAR 8BB3 pCDH gBLOCK sequence

<400>  314
agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc ttcctctaca       60

gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca tgctccgtga      120

tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct ccgggtaaaa      180

tctacatttg ggccccgctc gcaggcacat gtggagtgct cctcctctcc ctggtgatta      240

ccctgtactg caaaaggggc cgcaaaaaac tcctttacat ttttaagcag ccttttatga      300

ggccagtaca gacgactcaa gaggaagacg ggtgctcatg ccgctttcct gaggaggagg      360

aaggagggtg cgaactgcgc gttaagttct cccgatcagc cgacgcgcct gcttacaagc      420

agggccagaa ccaactgtac aacgagctga atctcggtag acgggaagag tacgacgtgt      480

tggacaaacg gagaggccgc gacccagaaa tgggcggcaa gcctcgcagg aaaaaccccc      540

aggagggact gtacaatgag ttgcagaaag ataagatggc agaagcttat agcgagatcg      600

gaatgaaggg ggaaaggaga cgagggaaag gacacgacgg cctttatcag ggcctgtcca      660

cagcaacaaa agatacgtat gacgccctcc atatgcaggc acttccacca cggtgataag      720

tttaaacccg ctgatcaggc ggccgcgaag gatctgcgat cgctccggtg cccgtcag        778


<210>  315
<211>  1983
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR E6 FcH/8/4-1BB/CD3z sequence

<400>  315
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtggcggagg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      900

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1080

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1140

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1440

aaaatctaca tttgggcccc gctcgcaggc acatgtggag tgctcctcct ctccctggtg     1500

attaccctgt actgcaaaag gggccgcaaa aaactccttt acatttttaa gcagcctttt     1560

atgaggccag tacagacgac tcaagaggaa gacgggtgct catgccgctt tcctgaggag     1620

gaggaaggag ggtgcgaact gcgcgttaag ttctcccgat cagccgacgc gcctgcttac     1680

aagcagggcc agaaccaact gtacaacgag ctgaatctcg gtagacggga agagtacgac     1740

gtgttggaca aacggagagg ccgcgaccca gaaatgggcg gcaagcctcg caggaaaaac     1800

ccccaggagg gactgtacaa tgagttgcag aaagataaga tggcagaagc ttatagcgag     1860

atcggaatga agggggaaag gagacgaggg aaaggacacg acggccttta tcagggcctg     1920

tccacagcaa caaaagatac gtatgacgcc ctccatatgc aggcacttcc accacggtga     1980

taa                                                                   1983


<210>  316
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR E6 FcH/8/4-1BB/CD3z sequence

<400>  316

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                485                 490                 495     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            500                 505                 510         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        515                 520                 525             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    530                 535                 540                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
545                 550                 555                 560 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                565                 570                 575     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            580                 585                 590         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        595                 600                 605             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    610                 615                 620                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
625                 630                 635                 640 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                645                 650                 655     


Pro Pro Arg 
            


<210>  317
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 CAR FcH pCDH gBLOCK sequence

<400>  317
agtacctcta atctggcctc aggtatccct gcacgatttt ctggatctgg ttcaggttct       60

gattacaccc tcactatctc tagcctggag cctgaagact ttgccgttta ttactgccag      120

cagaggtcta gctccccatt cacctttggg agtgggacca aggttgaaat taaagcacct      180

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      240

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      300

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      360

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      420

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      480

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      540

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      600

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      660

accacgcctc ccgtgctg                                                    678


<210>  318
<211>  2022
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR E6 Fc/4/4-1BB/CD3z sequence

<400>  318
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtggcggagg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aagagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      840

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      900

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      960

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg     1020

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1080

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1140

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1200

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1260

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1320

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1380

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1440

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaaat ggccctgatt     1500

gtgctggggg gcgtcgccgg cctcctgctt ttcattgggc taggcatctt cttcaaaagg     1560

ggccgcaaaa aactccttta catttttaag cagcctttta tgaggccagt acagacgact     1620

caagaggaag acgggtgctc atgccgcttt cctgaggagg aggaaggagg gtgcgaactg     1680

cgcgttaagt tctcccgatc agccgacgcg cctgcttaca agcagggcca gaaccaactg     1740

tacaacgagc tgaatctcgg tagacgggaa gagtacgacg tgttggacaa acggagaggc     1800

cgcgacccag aaatgggcgg caagcctcgc aggaaaaacc cccaggaggg actgtacaat     1860

gagttgcaga aagataagat ggcagaagct tatagcgaga tcggaatgaa gggggaaagg     1920

agacgaggga aaggacacga cggcctttat cagggcctgt ccacagcaac aaaagatacg     1980

tatgacgccc tccatatgca ggcacttcca ccacggtgat aa                        2022


<210>  319
<211>  672
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR E6 Fc/4/4-1BB/CD3z sequence

<400>  319

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr 
            260                 265                 270         


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
            500                 505                 510         


Gly Leu Gly Ile Phe Phe Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        515                 520                 525             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    530                 535                 540                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
545                 550                 555                 560 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
                565                 570                 575     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            580                 585                 590         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        595                 600                 605             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    610                 615                 620                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
625                 630                 635                 640 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                645                 650                 655     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665                 670         


<210>  320
<211>  772
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 CAR 44BB3 pCDH gBLOCK sequence

<400>  320
agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc ttcctctaca       60

gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca tgctccgtga      120

tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct ccgggtaaaa      180

tggccctgat tgtgctgggg ggcgtcgccg gcctcctgct tttcattggg ctaggcatct      240

tcttcaaaag gggccgcaaa aaactccttt acatttttaa gcagcctttt atgaggccag      300

tacagacgac tcaagaggaa gacgggtgct catgccgctt tcctgaggag gaggaaggag      360

ggtgcgaact gcgcgttaag ttctcccgat cagccgacgc gcctgcttac aagcagggcc      420

agaaccaact gtacaacgag ctgaatctcg gtagacggga agagtacgac gtgttggaca      480

aacggagagg ccgcgaccca gaaatgggcg gcaagcctcg caggaaaaac ccccaggagg      540

gactgtacaa tgagttgcag aaagataaga tggcagaagc ttatagcgag atcggaatga      600

agggggaaag gagacgaggg aaaggacacg acggccttta tcagggcctg tccacagcaa      660

caaaagatac gtatgacgcc ctccatatgc aggcacttcc accacggtga taagtttaaa      720

cccgctgatc aggcggccgc gaaggatctg cgatcgctcc ggtgcccgtc ag              772


<210>  321
<211>  1977
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR E6 FcH/4/4-1BB/CD3z sequence

<400>  321
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtggcggagg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      900

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1080

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1140

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1440

aaaatggccc tgattgtgct ggggggcgtc gccggcctcc tgcttttcat tgggctaggc     1500

atcttcttca aaaggggccg caaaaaactc ctttacattt ttaagcagcc ttttatgagg     1560

ccagtacaga cgactcaaga ggaagacggg tgctcatgcc gctttcctga ggaggaggaa     1620

ggagggtgcg aactgcgcgt taagttctcc cgatcagccg acgcgcctgc ttacaagcag     1680

ggccagaacc aactgtacaa cgagctgaat ctcggtagac gggaagagta cgacgtgttg     1740

gacaaacgga gaggccgcga cccagaaatg ggcggcaagc ctcgcaggaa aaacccccag     1800

gagggactgt acaatgagtt gcagaaagat aagatggcag aagcttatag cgagatcgga     1860

atgaaggggg aaaggagacg agggaaagga cacgacggcc tttatcaggg cctgtccaca     1920

gcaacaaaag atacgtatga cgccctccat atgcaggcac ttccaccacg gtgataa        1977


<210>  322
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR E6 FcH/4/4-1BB/CD3z sequence

<400>  322

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe 
                485                 490                 495     


Ile Gly Leu Gly Ile Phe Phe Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            500                 505                 510         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        515                 520                 525             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    530                 535                 540                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
545                 550                 555                 560 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                565                 570                 575     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            580                 585                 590         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        595                 600                 605             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    610                 615                 620                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
625                 630                 635                 640 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                645                 650                 655     


Arg 
    


<210>  323
<211>  1506
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR E6 IgD/8/4-1BB/CD3z sequence

<400>  323
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtggcggagg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aagagtctcc aaaggcacag gcctcctcag tgcccactgc acaaccccaa      840

gcagagggca gcctcgccaa ggcaaccaca gccccagcca ccacccgtaa cacaggaaga      900

ggcggcgaag agaagaaaaa ggagaaggag aaagaggaac aagaagagag agagacaaag      960

acaccaatct acatttgggc cccgctcgca ggcacatgtg gagtgctcct cctctccctg     1020

gtgattaccc tgtactgcaa aaggggccgc aaaaaactcc tttacatttt taagcagcct     1080

tttatgaggc cagtacagac gactcaagag gaagacgggt gctcatgccg ctttcctgag     1140

gaggaggaag gagggtgcga actgcgcgtt aagttctccc gatcagccga cgcgcctgct     1200

tacaagcagg gccagaacca actgtacaac gagctgaatc tcggtagacg ggaagagtac     1260

gacgtgttgg acaaacggag aggccgcgac ccagaaatgg gcggcaagcc tcgcaggaaa     1320

aacccccagg agggactgta caatgagttg cagaaagata agatggcaga agcttatagc     1380

gagatcggaa tgaaggggga aaggagacga gggaaaggac acgacggcct ttatcagggc     1440

ctgtccacag caacaaaaga tacgtatgac gccctccata tgcaggcact tccaccacgg     1500

tgataa                                                                1506


<210>  324
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR E6 IgD/8/4-1BB/CD3z sequence

<400>  324

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Glu Ser Pro Lys Ala Gln Ala Ser 
            260                 265                 270         


Ser Val Pro Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala 
        275                 280                 285             


Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu 
    290                 295                 300                 


Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys 
305                 310                 315                 320 


Thr Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
                325                 330                 335     


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210>  325
<211>  475
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 CAR IgD8 pcDH gBLOCK sequence

<400>  325
agtacctcta atctggcctc aggtatccct gcacgatttt ctggatctgg ttcaggttct       60

gattacaccc tcactatctc tagcctggag cctgaagact ttgccgttta ttactgccag      120

cagaggtcta gctccccatt cacctttggg agtgggacca aggttgaaat taaagagtct      180

ccaaaggcac aggcctcctc agtgcccact gcacaacccc aagcagaggg cagcctcgcc      240

aaggcaacca cagccccagc caccacccgt aacacaggaa gaggcggcga agagaagaaa      300

aaggagaagg agaaagagga acaagaagag agagagacaa agacaccaat ctacatttgg      360

gccccgctcg caggcacatg tggagtgctc ctcctctccc tggtgattac cctgtactgc      420

aaaaggggcc gcaaaaaact cctttacatt tttaagcagc cttttatgag gccag           475


<210>  326
<211>  502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 CAR BB 3 pCDH gBLOCK sequence

<400>  326
acatttttaa gcagcctttt atgaggccag tacagacgac tcaagaggaa gacgggtgct       60

catgccgctt tcctgaggag gaggaaggag ggtgcgaact gcgcgttaag ttctcccgat      120

cagccgacgc gcctgcttac aagcagggcc agaaccaact gtacaacgag ctgaatctcg      180

gtagacggga agagtacgac gtgttggaca aacggagagg ccgcgaccca gaaatgggcg      240

gcaagcctcg caggaaaaac ccccaggagg gactgtacaa tgagttgcag aaagataaga      300

tggcagaagc ttatagcgag atcggaatga agggggaaag gagacgaggg aaaggacacg      360

acggccttta tcagggcctg tccacagcaa caaaagatac gtatgacgcc ctccatatgc      420

aggcacttcc accacggtga taagtttaaa cccgctgatc aggcggccgc gaaggatctg      480

cgatcgctcc ggtgcccgtc ag                                               502


<210>  327
<211>  1500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR E6 IgD/4/4-1BB/CD3z sequence

<400>  327
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtggcggagg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aagagtctcc aaaggcacag gcctcctcag tgcccactgc acaaccccaa      840

gcagagggca gcctcgccaa ggcaaccaca gccccagcca ccacccgtaa cacaggaaga      900

ggcggcgaag agaagaaaaa ggagaaggag aaagaggaac aagaagagag agagacaaag      960

acaccaatgg ccctgattgt gctggggggc gtcgccggcc tcctgctttt cattgggcta     1020

ggcatcttct tcaaaagggg ccgcaaaaaa ctcctttaca tttttaagca gccttttatg     1080

aggccagtac agacgactca agaggaagac gggtgctcat gccgctttcc tgaggaggag     1140

gaaggagggt gcgaactgcg cgttaagttc tcccgatcag ccgacgcgcc tgcttacaag     1200

cagggccaga accaactgta caacgagctg aatctcggta gacgggaaga gtacgacgtg     1260

ttggacaaac ggagaggccg cgacccagaa atgggcggca agcctcgcag gaaaaacccc     1320

caggagggac tgtacaatga gttgcagaaa gataagatgg cagaagctta tagcgagatc     1380

ggaatgaagg gggaaaggag acgagggaaa ggacacgacg gcctttatca gggcctgtcc     1440

acagcaacaa aagatacgta tgacgccctc catatgcagg cacttccacc acggtgataa     1500


<210>  328
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR E6 IgD/4/4-1BB/CD3z sequence

<400>  328

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Glu Ser Pro Lys Ala Gln Ala Ser 
            260                 265                 270         


Ser Val Pro Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala 
        275                 280                 285             


Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu 
    290                 295                 300                 


Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys 
305                 310                 315                 320 


Thr Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu 
                325                 330                 335     


Phe Ile Gly Leu Gly Ile Phe Phe Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg 
        


<210>  329
<211>  469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 CAR IgD4 pcDH gBLOCK sequence

<400>  329
agtacctcta atctggcctc aggtatccct gcacgatttt ctggatctgg ttcaggttct       60

gattacaccc tcactatctc tagcctggag cctgaagact ttgccgttta ttactgccag      120

cagaggtcta gctccccatt cacctttggg agtgggacca aggttgaaat taaagagtct      180

ccaaaggcac aggcctcctc agtgcccact gcacaacccc aagcagaggg cagcctcgcc      240

aaggcaacca cagccccagc caccacccgt aacacaggaa gaggcggcga agagaagaaa      300

aaggagaagg agaaagagga acaagaagag agagagacaa agacaccaat ggccctgatt      360

gtgctggggg gcgtcgccgg cctcctgctt ttcattgggc taggcatctt cttcaaaagg      420

ggccgcaaaa aactccttta catttttaag cagcctttta tgaggccag                  469


<210>  330
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR E6 X4/8/4-1BB/CD3z sequence

<400>  330
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtggcggagg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aagacaagac gcacaccaag ccacctaaac cagctccaga actgctcgga      840

ggtcctggca ccggaaccgg aggacctacc atcaaaccac ctaagccacc taagcctgct      900

cctaacctgc tcggaggacc tatctacatt tgggccccgc tcgcaggcac atgtggagtg      960

ctcctcctct ccctggtgat taccctgtac tgcaaaaggg gccgcaaaaa actcctttac     1020

atttttaagc agccttttat gaggccagta cagacgactc aagaggaaga cgggtgctca     1080

tgccgctttc ctgaggagga ggaaggaggg tgcgaactgc gcgttaagtt ctcccgatca     1140

gccgacgcgc ctgcttacaa gcagggccag aaccaactgt acaacgagct gaatctcggt     1200

agacgggaag agtacgacgt gttggacaaa cggagaggcc gcgacccaga aatgggcggc     1260

aagcctcgca ggaaaaaccc ccaggaggga ctgtacaatg agttgcagaa agataagatg     1320

gcagaagctt atagcgagat cggaatgaag ggggaaagga gacgagggaa aggacacgac     1380

ggcctttatc agggcctgtc cacagcaaca aaagatacgt atgacgccct ccatatgcag     1440

gcacttccac cacggtgata a                                               1461


<210>  331
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR E6 X4/8/4-1BB/CD3z sequence

<400>  331

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Asp Lys Thr His Thr Lys Pro Pro 
            260                 265                 270         


Lys Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Thr Gly Gly 
        275                 280                 285             


Pro Thr Ile Lys Pro Pro Lys Pro Pro Lys Pro Ala Pro Asn Leu Leu 
    290                 295                 300                 


Gly Gly Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  332
<211>  430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 CAR X48 pCDH gBLOCK sequence

<400>  332
agtacctcta atctggcctc aggtatccct gcacgatttt ctggatctgg ttcaggttct       60

gattacaccc tcactatctc tagcctggag cctgaagact ttgccgttta ttactgccag      120

cagaggtcta gctccccatt cacctttggg agtgggacca aggttgaaat taaagacaag      180

acgcacacca agccacctaa accagctcca gaactgctcg gaggtcctgg caccggaacc      240

ggaggaccta ccatcaaacc acctaagcca cctaagcctg ctcctaacct gctcggagga      300

cctatctaca tttgggcccc gctcgcaggc acatgtggag tgctcctcct ctccctggtg      360

attaccctgt actgcaaaag gggccgcaaa aaactccttt acatttttaa gcagcctttt      420

atgaggccag                                                             430


<210>  333
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR E6 X4/4/4-1BB/CD3z sequence

<400>  333
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtggcggagg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aagacaagac gcacaccaag ccacctaaac cagctccaga actgctcgga      840

ggtcctggca ccggaaccgg aggacctacc atcaaaccac ctaagccacc taagcctgct      900

cctaacctgc tcggaggacc tatggccctg attgtgctgg ggggcgtcgc cggcctcctg      960

cttttcattg ggctaggcat cttcttcaaa aggggccgca aaaaactcct ttacattttt     1020

aagcagcctt ttatgaggcc agtacagacg actcaagagg aagacgggtg ctcatgccgc     1080

tttcctgagg aggaggaagg agggtgcgaa ctgcgcgtta agttctcccg atcagccgac     1140

gcgcctgctt acaagcaggg ccagaaccaa ctgtacaacg agctgaatct cggtagacgg     1200

gaagagtacg acgtgttgga caaacggaga ggccgcgacc cagaaatggg cggcaagcct     1260

cgcaggaaaa acccccagga gggactgtac aatgagttgc agaaagataa gatggcagaa     1320

gcttatagcg agatcggaat gaagggggaa aggagacgag ggaaaggaca cgacggcctt     1380

tatcagggcc tgtccacagc aacaaaagat acgtatgacg ccctccatat gcaggcactt     1440

ccaccacggt gataa                                                      1455


<210>  334
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR E6 X4/4/4-1BB/CD3z sequence

<400>  334

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Asp Lys Thr His Thr Lys Pro Pro 
            260                 265                 270         


Lys Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Thr Gly Gly 
        275                 280                 285             


Pro Thr Ile Lys Pro Pro Lys Pro Pro Lys Pro Ala Pro Asn Leu Leu 
    290                 295                 300                 


Gly Gly Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu 
305                 310                 315                 320 


Leu Phe Ile Gly Leu Gly Ile Phe Phe Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  335
<211>  424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 CAR X44 pCDH gBLOCK sequence

<400>  335
agtacctcta atctggcctc aggtatccct gcacgatttt ctggatctgg ttcaggttct       60

gattacaccc tcactatctc tagcctggag cctgaagact ttgccgttta ttactgccag      120

cagaggtcta gctccccatt cacctttggg agtgggacca aggttgaaat taaagacaag      180

acgcacacca agccacctaa accagctcca gaactgctcg gaggtcctgg caccggaacc      240

ggaggaccta ccatcaaacc acctaagcca cctaagcctg ctcctaacct gctcggagga      300

cctatggccc tgattgtgct ggggggcgtc gccggcctcc tgcttttcat tgggctaggc      360

atcttcttca aaaggggccg caaaaaactc ctttacattt ttaagcagcc ttttatgagg      420

ccag                                                                   424


<210>  336
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR E6 8+4/4/4-1BB/CD3z sequence

<400>  336
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtggcggagg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aaacgacaac cccggccccc agaccaccaa cgccagcccc caccatcgcc      840

agccaacccc tgtctctgag accagaagcc tgtaggcctg ccgccggtgg agctgtgcac      900

acaagaggac tggatttcgc ctgtgatatg gccctgattg tgctgggggg cgtcgccggc      960

ctcctgcttt tcattgggct aggcatcttc ttcaaaaggg gccgcaaaaa actcctttac     1020

atttttaagc agccttttat gaggccagta cagacgactc aagaggaaga cgggtgctca     1080

tgccgctttc ctgaggagga ggaaggaggg tgcgaactgc gcgttaagtt ctcccgatca     1140

gccgacgcgc ctgcttacaa gcagggccag aaccaactgt acaacgagct gaatctcggt     1200

agacgggaag agtacgacgt gttggacaaa cggagaggcc gcgacccaga aatgggcggc     1260

aagcctcgca ggaaaaaccc ccaggaggga ctgtacaatg agttgcagaa agataagatg     1320

gcagaagctt atagcgagat cggaatgaag ggggaaagga gacgagggaa aggacacgac     1380

ggcctttatc agggcctgtc cacagcaaca aaagatacgt atgacgccct ccatatgcag     1440

gcacttccac cacggtgata a                                               1461


<210>  337
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR E6 8+4/4/4-1BB/CD3z sequence

<400>  337

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly 
305                 310                 315                 320 


Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  338
<211>  430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 CAR CD844 pCDH gBLOCK sequence

<400>  338
agtacctcta atctggcctc aggtatccct gcacgatttt ctggatctgg ttcaggttct       60

gattacaccc tcactatctc tagcctggag cctgaagact ttgccgttta ttactgccag      120

cagaggtcta gctccccatt cacctttggg agtgggacca aggttgaaat taaaacgaca      180

accccggccc ccagaccacc aacgccagcc cccaccatcg ccagccaacc cctgtctctg      240

agaccagaag cctgtaggcc tgccgccggt ggagctgtgc acacaagagg actggatttc      300

gcctgtgata tggccctgat tgtgctgggg ggcgtcgccg gcctcctgct tttcattggg      360

ctaggcatct tcttcaaaag gggccgcaaa aaactccttt acatttttaa gcagcctttt      420

atgaggccag                                                             430


<210>  339
<211>  820
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 scFV sequence in CAR

<400>  339
gagggccacc atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca       60

cgctgccagg cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg      120

aagcctcaga ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg      180

ggtaagacag gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac      240

ttatatatat tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa      300

gaactccctc tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg      360

tgcacgcctc ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac      420

cgtgacagtt tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag      480

tgatattgtg ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac      540

aattacatgt cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta      600

tcaacagaaa ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc      660

cggcgtgcct gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa      720

ccccgtagaa gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt      780

tacgttcggc gggggcacaa aggtcgaaat taagagaacc                            820


<210>  340
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 scFV sequence in CAR

<400>  340

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 


<210>  341
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 scFV sequence in CAR

<400>  341
gaggtccagc tggttgagag tggcggtggg ctggttaagc ctggcggctc cctgcggctg       60

agctgcgccg cgagtggatt tactttcagc cgatatggga tgagttgggt gcggcaagct      120

cccgggaaga ggctggaatg ggtctcaaca atctccgggg ggggcactta catctattac      180

cccgactcag tcaaggggag atttaccatt tcacgagaca acgctaagaa taccctgtat      240

ttgcagatga attctctgag agcagaggac acagctgttt actattgtac ccgcgacaac      300

tatggcagga actacgacta cggtatggac tattggggac aagggacatt ggttacagtg      360

agcagtggcg gcgggggcag cggaggagga ggcagcggtg gggggggcag cgagatagtg      420

ctcacgcagt cacccgcgac tctcagtctc tcacctgggg aacgagctac cctgacgtgc      480

tctgctacct cctcagtgtc atatattcac tggtatcagc aacggcccgg gcagtcccct      540

agattgctca tttatagtac ctctaatctg gcctcaggta tccctgcacg attttctgga      600

tctggttcag gttctgatta caccctcact atctctagcc tggagcctga agactttgcc      660

gtttattact gccagcagag gtctagctcc ccattcacct ttgggagtgg gaccaaggtt      720

gaaattaaa                                                              729


<210>  342
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 scFV sequence in CAR

<400>  342

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro 
                165                 170                 175     


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  343
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  343
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

cca                                                                     63


<210>  344
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  344

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  345
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain sequence

<400>  345
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgat                                                       135


<210>  346
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain sequence

<400>  346

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  347
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD4 hinge domain sequence

<400>  347
tcgggacagg tcctgctgga atccaacatc aaggttctgc ccacatggtc caccccggtg       60

cagcca                                                                  66


<210>  348
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 hinge domain sequence

<400>  348

Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp 
1               5                   10                  15      


Ser Thr Pro Val Gln Pro 
            20          


<210>  349
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 hinge domain sequence

<400>  349
aaacaccttt gtccaagtcc cctatttccc ggaccttcta agccc                       45


<210>  350
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge domain sequence

<400>  350

Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
1               5                   10                  15  


<210>  351
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8+CD4 hinge domain sequence

<400>  351
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgattcggg acaggtcctg ctggaatcca acatcaaggt tctgcccaca      180

tggtccaccc cggtgcagcc a                                                201


<210>  352
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8+CD4 hinge domain sequence

<400>  352

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ser Gly Gln 
        35                  40                  45              


Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro 
    50                  55                  60                  


Val Gln Pro 
65          


<210>  353
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8+CD28 hinge domain sequence

<400>  353
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgataaaca cctttgtcca agtcccctat ttcccggacc ttctaagccc      180


<210>  354
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8+CD28 hinge domain sequence

<400>  354

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Lys His Leu 
        35                  40                  45              


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
    50                  55                  60  


<210>  355
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28+CD4 hinge domain sequence

<400>  355
aaacaccttt gtccaagtcc cctatttccc ggaccttcta agccctcggg acaggtcctg       60

ctggaatcca acatcaaggt tctgcccaca tggtccaccc cggtgcagcc a               111


<210>  356
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28+CD4 hinge domain sequence

<400>  356

Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Ser 
1               5                   10                  15      


Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser 
            20                  25                  30          


Thr Pro Val Gln Pro 
        35          


<210>  357
<211>  174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgD hinge domain sequence

<400>  357
gagtctccaa aggcacaggc ctcctcagtg cccactgcac aaccccaagc agagggcagc       60

ctcgccaagg caaccacagc cccagccacc acccgtaaca caggaagagg cggcgaagag      120

aagaaaaagg agaaggagaa agaggaacaa gaagagagag agacaaagac acca            174


<210>  358
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgD hinge domain sequence

<400>  358

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro 
    50                  55              


<210>  359
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  X4 linker (IgG1 and IgG2 modified hinge region) sequence

<400>  359
gacaagacgc acaccaagcc acctaaacca gctccagaac tgctcggagg tcctggcacc       60

ggaaccggag gacctaccat caaaccacct aagccaccta agcctgctcc taacctgctc      120

ggaggacct                                                              129


<210>  360
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  X4 linker (IgG1 and IgG2 modified hinge region) sequence

<400>  360

Asp Lys Thr His Thr Lys Pro Pro Lys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Gly Thr Gly Thr Gly Gly Pro Thr Ile Lys Pro Pro Lys Pro 
            20                  25                  30          


Pro Lys Pro Ala Pro Asn Leu Leu Gly Gly Pro 
        35                  40              


<210>  361
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta transmembrane domain sequence

<400>  361
ctctgctacc tgctggatgg aatcctcttc atctatggtg tcattctcac tgccttgttc       60

ctg                                                                     63


<210>  362
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta transmembrane domain sequence

<400>  362

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  363
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain sequence

<400>  363
atctacattt gggccccgct cgcaggcaca tgtggagtgc tcctcctctc cctggtgatt       60

accctgtact gc                                                           72


<210>  364
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain sequence

<400>  364

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  365
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD4 transmembrane domain sequence

<400>  365
atggccctga ttgtgctggg gggcgtcgcc ggcctcctgc ttttcattgg gctaggcatc       60

ttcttc                                                                  66


<210>  366
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 transmembrane domain sequence

<400>  366

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  367
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain sequence

<400>  367
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  368
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain sequence

<400>  368

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  369
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB transmembrane domain sequence

<400>  369
atcatctcct tctttcttgc gctgacgtcg actgcgttgc tcttcctgct gttcttcctc       60

acgctccgtt tctctgttgt t                                                 81


<210>  370
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB transmembrane domain sequence

<400>  370

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  371
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OX40 transmembrane domain sequence

<400>  371
gttgccgcca tcctgggcct gggcctggtg ctggggctgc tgggccccct ggccatcctg       60

ctggccctgt acctgctc                                                     78


<210>  372
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40 transmembrane domain sequence

<400>  372

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
            20                  25      


<210>  373
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain sequence

<400>  373
cgcgttaagt tctcccgatc agccgacgcg cctgcttaca agcagggcca gaaccaactg       60

tacaacgagc tgaatctcgg tagacgggaa gagtacgacg tgttggacaa acggagaggc      120

cgcgacccag aaatgggcgg caagcctcgc aggaaaaacc cccaggaggg actgtacaat      180

gagttgcaga aagataagat ggcagaagct tatagcgaga tcggaatgaa gggggaaagg      240

agacgaggga aaggacacga cggcctttat cagggcctgt ccacagcaac aaaagatacg      300

tatgacgccc tccatatgca ggcacttcca ccacgg                                336


<210>  374
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain sequence

<400>  374

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  375
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain variant sequence

<400>  375
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  376
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain variant sequence

<400>  376

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  377
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 domain sequence

<400>  377
agaagcaagc ggtctcggct cctgcattct gattacatga acatgacccc aagaagacca       60

ggccccacca ggaaacatta ccagccctac gctccgccac gcgacttcgc tgcctaccgg      120

tcc                                                                    123


<210>  378
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 domain sequence

<400>  378

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  379
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB domain sequence

<400>  379
aaaaggggcc gcaaaaaact cctttacatt tttaagcagc cttttatgag gccagtacag       60

acgactcaag aggaagacgg gtgctcatgc cgctttcctg aggaggagga aggagggtgc      120

gaactg                                                                 126


<210>  380
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB domain sequence

<400>  380

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  381
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OX40 domain sequence

<400>  381
cggagggacc agaggctgcc ccccgatgcc cacaagcccc ctgggggagg cagtttccgg       60

acccccatcc aagaggagca ggccgacgcc cactccaccc tggccaagat c               111


<210>  382
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40 domain sequence

<400>  382

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile 
        35          


<210>  383
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti CD3 scFV clone 12F6 (VH-VL) sequence

<400>  383
caggtgcagc tggtgcagag cggaggtgga gtggtccaac ctggaagatc tctgagactg       60

agctgtaagg ctagcgggta cacgttcaca tcttacacga tgcactgggt gaggcaagcc      120

cccggtaagg gcctggaatg gatcggatat ataaacccca gctcagggta taccaaatat      180

aatcagaagt tcaaagatcg gttcacgatt tctgctgata aaagtaagtc caccgctttc      240

ctgcagatgg actcactcag gccagaagat actggtgttt atttctgtgc aaggtggcag      300

gactacgacg tgtactttga ctattggggg caggggacgc ctgtaacagt atcaagcggc      360

ggtggcggat ccggcggtgg cggatccggc ggtggcggat ccgatattca gatgacccag      420

agcccgagca gcctgagcgc gagcgtgggc gatcgcgtga ccatgacctg ccgcgcgagc      480

agcagcgtga gctatatgca ttggtatcag cagaccccgg gcaaagcgcc gaaaccgtgg      540

atttatgcga ccagcaacct ggcgagcggc gtgccgagcc gctttagcgg cagcggcagc      600

ggcaccgatt ataccctgac cattagcagc ctgcagccgg aagatattgc gacctattat      660

tgccagcagt ggagcagcaa cccgccgacc tttggccagg gcaccaaact gcagattacc      720

cgc                                                                    723


<210>  384
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti CD3 scFV clone 12F6 (VH-VL) sequence

<400>  384

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Gln Asp Tyr Asp Val Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Thr Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
225                 230                 235                 240 


Arg 
    


<210>  385
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti CD3 scFV clone 12F6 (VL-VH) sequence

<400>  385
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

atgacctgcc gcgcgagcag cagcgtgagc tatatgcatt ggtatcagca gaccccgggc      120

aaagcgccga aaccgtggat ttatgcgacc agcaacctgg cgagcggcgt gccgagccgc      180

tttagcggca gcggcagcgg caccgattat accctgacca ttagcagcct gcagccggaa      240

gatattgcga cctattattg ccagcagtgg agcagcaacc cgccgacctt tggccagggc      300

accaaactgc agattacccg cggcggtggc ggatccggcg gtggcggatc cggcggtggc      360

ggatcccagg tgcagctggt gcagagcgga ggtggagtgg tccaacctgg aagatctctg      420

agactgagct gtaaggctag cgggtacacg ttcacatctt acacgatgca ctgggtgagg      480

caagcccccg gtaagggcct ggaatggatc ggatatataa accccagctc agggtatacc      540

aaatataatc agaagttcaa agatcggttc acgatttctg ctgataaaag taagtccacc      600

gctttcctgc agatggactc actcaggcca gaagatactg gtgtttattt ctgtgcaagg      660

tggcaggact acgacgtgta ctttgactat tgggggcagg ggacgcctgt aacagtatca      720

agc                                                                    723


<210>  386
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti CD3 scFV clone 12F6 (VL-VH) sequence

<400>  386

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
        115                 120                 125             


Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Thr Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
                165                 170                 175     


Ser Gly Tyr Thr Lys Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile 
            180                 185                 190         


Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu 
        195                 200                 205             


Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Trp Gln Asp Tyr 
    210                 215                 220                 


Asp Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  387
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti CD3 scFV clone OKT3 (VH-VL) sequence

<400>  387
caggtgcagc tggtgcagag cggaggcgga gtggtgcagc ctggaagaag cctgcgcctg       60

agctgcaaag cgagcggcta tacctttacc cgctatacca tgcattgggt gcgccaggcg      120

ccgggcaaag gcctggaatg gattggctat attaacccga gccgcggcta taccaactat      180

aaccagaaag tgaaagatcg ctttaccatt agcaccgata aaagcaaaag caccgcgttt      240

ctgcagatgg atagcctgcg cccggaagat accgcggtgt attattgcgc gcgctattat      300

gatgatcatt attgcctgga ttattggggc cagggcacca ccctgaccgt gagcagcggc      360

ggtggcggat ccggcggtgg cggatccggc ggtggcggat ccgatattca gatgacccag      420

agcccgagca gcctgagcgc gagcgtgggc gatcgcgtga ccattacctg cagcgcgagc      480

agcagcgtga gctatatgaa ctggtatcag cagaccccgg gcaaagcgcc gaaacgctgg      540

atttatgata ccagcaaact ggcgagcggc gtgccgagcc gctttagcgg cagcggcagc      600

ggcaccgatt atacctttac cattagcagc ctgcagccgg aagatattgc gacctattat      660

tgccagcagt ggagcagcaa cccgtttacc tttggccagg gcaccaaact gcagattacc      720

cgc                                                                    723


<210>  388
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti CD3 scFV clone OKT3 (VH-VL) sequence

<400>  388

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
225                 230                 235                 240 


Arg 
    


<210>  389
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti CD3 scFV clone OKT3 (VH-VL) sequence

<400>  389
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgca gcgcgagcag cagcgtgagc tatatgaact ggtatcagca gaccccgggc      120

aaagcgccga aacgctggat ttatgatacc agcaaactgg cgagcggcgt gccgagccgc      180

tttagcggca gcggcagcgg caccgattat acctttacca ttagcagcct gcagccggaa      240

gatattgcga cctattattg ccagcagtgg agcagcaacc cgtttacctt tggccagggc      300

accaaactgc agattacccg cggcggtggc ggatccggcg gtggcggatc cggcggtggc      360

ggatcccagg tgcagctggt gcagagcgga ggcggagtgg tgcagcctgg aagaagcctg      420

cgcctgagct gcaaagcgag cggctatacc tttacccgct ataccatgca ttgggtgcgc      480

caggcgccgg gcaaaggcct ggaatggatt ggctatatta acccgagccg cggctatacc      540

aactataacc agaaagtgaa agatcgcttt accattagca ccgataaaag caaaagcacc      600

gcgtttctgc agatggatag cctgcgcccg gaagataccg cggtgtatta ttgcgcgcgc      660

tattatgatg atcattattg cctggattat tggggccagg gcaccaccct gaccgtgagc      720

agc                                                                    723


<210>  390
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti CD3 scFV clone OKT3 (VH-VL) sequence

<400>  390

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
        115                 120                 125             


Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
                165                 170                 175     


Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile 
            180                 185                 190         


Ser Thr Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu 
        195                 200                 205             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
    210                 215                 220                 


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  391
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HumanizeE6 scFV (VH-VL) sequence

<400>  391
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa caccctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagcggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgaaattgtg      420

ttgacacagt ctccagccac cctgtctttg tctccagggg aaagagccac cctcacctgc      480

agcgccacca gcagtgttag ctacatccac tggtaccaac agaggcctgg ccagagcccc      540

aggctcctca tctatagcac ctccaacctg gccagcggca tcccagccag gttcagtggc      600

agtgggtctg ggagcgacta cactctcacc atcagcagcc tagagcctga agattttgca      660

gtttattact gtcagcagcg tagcagctcc cctttcacct ttggcagcgg caccaaagtg      720

gaaattaaa                                                              729


<210>  392
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HumanizeE6 scFV (VH-VL) sequence

<400>  392

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro 
                165                 170                 175     


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  393
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HumanizeE6 scFV (VL-VH) sequence

<400>  393
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctcacctgca gcgccaccag cagtgttagc tacatccact ggtaccaaca gaggcctggc      120

cagagcccca ggctcctcat ctatagcacc tccaacctgg ccagcggcat cccagccagg      180

ttcagtggca gtgggtctgg gagcgactac actctcacca tcagcagcct agagcctgaa      240

gattttgcag tttattactg tcagcagcgt agcagctccc ctttcacctt tggcagcggc      300

accaaagtgg aaattaaagg cggtggcgga tccggcggtg gcggatccgg cggtggcgga      360

tccgaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      420

ctctcctgtg cagcctctgg attcaccttc agtaggtatg gcatgagctg ggtccgccag      480

gctccaggga agaggctgga gtgggtctca accattagtg gcggaggcac ctacatatac      540

tacccagact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaacaccctg      600

tatctgcaaa tgaacagcct gagagccgag gacacggctg tgtattactg taccagagat      660

aactatggcc gcaactatga ttatggcatg gattattggg gccagggcac cctggtgacc      720

gtgagcagc                                                              729


<210>  394
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HumanizeE6 scFV (VL-VH) sequence

<400>  394

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    130                 135                 140                 


Ala Ser Gly Phe Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly 
                165                 170                 175     


Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg 
    210                 215                 220                 


Asn Tyr Asp Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  395
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HumanizeC2 scFV (VH-VL) sequence

<400>  395
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaact                                          747


<210>  396
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HumanizeC2 scFV (VH-VL) sequence

<400>  396

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 


<210>  397
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HumanizeE6 scFV (VL-VH) sequence

<400>  397
gacattgtgc tgacccagtc tccagcctcc ttggccgtgt ctccaggaca gagggccacc       60

atcacctgca gagccagtaa gagtgtcagt accagcggat actcctacat gcactggtat      120

cagcagaaac caggacaacc tcctaaactc ctgatttacc tggcatccaa tctggagagc      180

ggggtcccag ccaggttcag cggcagtggg tctgggaccg atttcaccct cacaattaat      240

cctgtggaag ctaatgatac tgcaaattat tactgtcagc acagtaggga gctgcctttc      300

acattcggcg gagggaccaa ggtggagatc aaacgaactg gcggtggcgg atccggcggt      360

ggcggatccg gcggtggcgg atccgaggtg cagctggtgg agtctggggg aggcctggtc      420

aagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtggctat      480

gccatgagct gggtccgcca ggctccaggg aaggggctgg agtgggtctc aaccattagt      540

agtggcggaa cctacatata ctaccccgac tcagtgaagg gccgattcac catctccaga      600

gacaacgcca agaactcact gtatctgcaa atgaacagcc tgagagccga ggacacggcc      660

gtgtattact gtgcgagact tgggggggat aattactacg aatacttcga tgtctggggc      720

aaagggacca cggtcaccgt ctcctcc                                          747


<210>  398
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HumanizeE6 scFV (VL-VH) sequence

<400>  398

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
145                 150                 155                 160 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                165                 170                 175     


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Lys Gly Thr Thr Val Thr Val Ser Ser 
                245                 


<210>  399
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G4S1 linker sequence

<400>  399
ggcggtggcg gatcc                                                        15


<210>  400
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4S1 linker sequence

<400>  400

Gly Gly Gly Gly Ser 
1               5   


<210>  401
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  [G4S1]x3 linker sequence

<400>  401
ggcggtggcg gatccggcgg tggcggatcc ggcggtggcg gatcc                       45


<210>  402
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [G4S1]x3 linker sequence

<400>  402

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  403
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8 aa GS linker sequence

<400>  403
ggcggttccg gcggtggatc cgga                                              24


<210>  404
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8 aa GS linker sequence

<400>  404

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  405
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12 aa GS linker sequence

<400>  405
ggcggttccg gcggtggatc cggcggtggc ggatccgga                              39


<210>  406
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12 aa GS linker sequence

<400>  406

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10          


<210>  407
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13 aa GS linker sequence

<400>  407
ggcggtggat ccggcggtgg cggatccggc ggtggatcc                              39


<210>  408
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13 aa GS linker sequence

<400>  408

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10              


<210>  409
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  22 aa GS linker sequence

<400>  409
ggcggtggaa gcggcggtgg cggatccggc agcggcggaa gcggcggtgg cggatccggc       60

ggtgga                                                                  66


<210>  410
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  22 aa GS linker sequence

<400>  410

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly 
            20          


<210>  411
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  24 aa GS linker sequence

<400>  411
ggcggttccg gcggtggatc cggcggtggc ggatccggag gcggttccgg cggtggatcc       60

ggcggtggcg gatccgga                                                     78


<210>  412
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  24 aa GS linker sequence

<400>  412

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser Gly 
            20                  


<210>  413
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 Heavy chain variable region sequence

<400>  413
caggtccagc tgcagcagtc tgggcctgag ctggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cagattcact gattatgcta tgaactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt tctctggtaa tacaaacttc      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatgt attactgtgc aagatcggat      300

tactacggcc catactttga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  414
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 Heavy chain variable region sequence

<400>  414

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Arg Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  415
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable framework region 1 (FWR1) sequence

<400>  415
caggtccagc tgcagcagtc tgggcctgag ctggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cagattcact                                        90


<210>  416
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable framework region 1 (FWR1) sequence

<400>  416

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Arg Phe Thr 
            20                  25                  30  


<210>  417
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  417
gattatgcta tgaac                                                        15


<210>  418
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  418

Asp Tyr Ala Met Asn 
1               5   


<210>  419
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable framework region 2 (FWR2) sequence

<400>  419
tgggtgaagc agagtcatgc aaagagtcta gagtggattg ga                          42


<210>  420
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable framework region 2 (FWR2) sequence

<400>  420

Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  421
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  421
gttattagta ctttctctgg taatacaaac ttcaaccaga agtttaaggg c                51


<210>  422
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  422

Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  423
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  423
aaggccacaa tgactgtaga caaatcctcc agcacagcct atatggaact tgccagattg       60

acatctgagg attctgccat gtattactgt gcaaga                                 96


<210>  424
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  424

Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  425
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  425
tcggattact acggcccata ctttgactac                                        30


<210>  426
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  426

Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr 
1               5                   10  


<210>  427
<211>  296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV1-18*04 heavy chain variable region sequence

<400>  427
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctacggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaga          296


<210>  428
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV1-18*04 heavy chain variable region sequence

<400>  428

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  429
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV1-18*04 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  429
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc                                        90


<210>  430
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV1-18*04 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  430

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  431
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV1-18*04 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  431
agctacggta tcagc                                                        15


<210>  432
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV1-18*04 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  432

Ser Tyr Gly Ile Ser 
1               5   


<210>  433
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV1-18*04 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  433
tgggtgcgac aggcccctgg acaagggctt gagtggatgg ga                          42


<210>  434
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV1-18*04 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  434

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  435
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV1-18*04 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  435
tggatcagcg cttacaatgg taacacaaac tatgcacaga agctccaggg c                51


<210>  436
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV1-18*04 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  436

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  437
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV1-18*04 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  437
agagtcacca tgaccacaga cacatccacg agcacagcct acatggagct gaggagcctg       60

agatctgacg acacggccgt gtattactgt gcgaga                                 96


<210>  438
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV1-18*04 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  438

Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  439
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable region sequence

<400>  439
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactacgcca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagtg atcagcacct tcagcggtaa cacaaacttc      180

aaccagaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaagcgac      300

tactacggcc catacttcga ctactggggc cagggcacca ccctgaccgt gtccagc         357


<210>  440
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable region sequence

<400>  440

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  441
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable framework region 1 (FWR1) acid 
       sequence

<400>  441
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc                                        90


<210>  442
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable framework region 1 (FWR1) acid 
       sequence

<400>  442

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  443
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  443
gactacgcca tgaac                                                        15


<210>  444
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  444

Asp Tyr Ala Met Asn 
1               5   


<210>  445
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable framework region 2 (FWR2) acid 
       sequence

<400>  445
tgggtgcgac aggcccctgg acaagggctt gagtggatgg ga                          42


<210>  446
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable framework region 2 (FWR2) acid 
       sequence

<400>  446

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  447
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  447
gtgatcagca ccttcagcgg taacacaaac ttcaaccaga agttcaaggg c                51


<210>  448
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  448

Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  449
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  449
agagtcacca tgaccacaga cacatccacg agcacagcct acatggagct gaggagcctg       60

agatctgacg acacggccgt gtattactgt gcgaga                                 96


<210>  450
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  450

Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  451
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  451
agcgactact acggcccata cttcgactac                                        30


<210>  452
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  452

Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr 
1               5                   10  


<210>  453
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 IgG1 heavy chain sequence

<400>  453
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactacgcca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagtg atcagcacct tcagcggtaa cacaaacttc      180

aaccagaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaagcgac      300

tactacggcc catacttcga ctactggggc cagggcacca ccctgaccgt gtccagcgct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgacagtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaatga taa                                  1353


<210>  454
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 IgG1 heavy chain sequence

<400>  454

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  455
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 IgG2 heavy chain sequence

<400>  455
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactacgcca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagtg atcagcacct tcagcggtaa cacaaacttc      180

aaccagaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaagcgac      300

tactacggcc catacttcga ctactggggc cagggcacca ccctgaccgt gtccagcgcc      360

tccaccaagg gcccatcggt cttccccctg gcgccctgct ccaggagcac ctccgagagc      420

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ctctgaccag cggcgtgcac accttcccag ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca acttcggcac ccagacctac      600

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagacagt tgagcgcaaa      660

tgttgtgtcg agtgcccacc gtgcccagca ccacctgtgg caggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacgtgcgtg      780

gtggtggacg tgagccacga agaccccgag gtccagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccacgg gaggagcagt tcaacagcac gttccgtgtg      900

gtcagcgtcc tcaccgttgt gcaccaggac tggctgaacg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc agcccccatc gagaaaacca tctccaaaac caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacacctc ccatgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaatagta a                                               1341


<210>  456
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 IgG2 heavy chain sequence

<400>  456

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  457
<211>  545
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain IgG1 gBLOCK sequence

<400>  457
tgctctgggt tccaggttcc actggtgacg cggcccagcc ggcccaggtt cagctggtgc       60

agtctggagc tgaggtgaag aagcctgggg cctcagtgaa ggtctcctgc aaggcttctg      120

gttacacctt taccgactac gccatgaact gggtgcgaca ggcccctgga caagggcttg      180

agtggatggg agtgatcagc accttcagcg gtaacacaaa cttcaaccag aagttcaagg      240

gcagagtcac catgaccaca gacacatcca cgagcacagc ctacatggag ctgaggagcc      300

tgagatctga cgacacggcc gtgtattact gtgcgagaag cgactactac ggcccatact      360

tcgactactg gggccagggc accaccctga ccgtgtccag cgctagcacc aagggcccat      420

cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg gccctgggct      480

gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca ggcgccctga      540

ccagc                                                                  545


<210>  458
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 Light Chain variable region sequence

<400>  458
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gaccattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

aacagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaa                                336


<210>  459
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 Light Chain variable region sequence

<400>  459

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  460
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable framework region 1 (FWR1) sequence

<400>  460
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgc                                                               69


<210>  461
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable framework region 1 (FWR1) sequence

<400>  461

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  462
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  462
agatctagtc agaccattgt acatagtaat ggaaacacct atttagaa                    48


<210>  463
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  463

Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  464
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable framework region 2 (FWR2) sequence

<400>  464
tggtacctgc agaaaccagg ccagtctcca aagctcctga tctac                       45


<210>  465
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable framework region 2 (FWR2) sequence

<400>  465

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  466
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  466
aaagtttcca accgattttc t                                                 21


<210>  467
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  467

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  468
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable framework region 3 (FWR3) sequence

<400>  468
ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcaac       60

agagtggagg ctgaggatct gggagtttat tactgc                                 96


<210>  469
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable framework region 3 (FWR3) sequence

<400>  469

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  470
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  470
tttcaaggtt cacatgttcc attcacg                                           27


<210>  471
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  471

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  472
<211>  300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable region sequence

<400>  472
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca agtctagtca gagcctcctg catagtgatg gaaagaccta tttgtattgg      120

tacctgcaga agccaggcca gtctccacag ctcctgatct atgaagtttc cagccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaggtat acaccttcct      300


<210>  473
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable region sequence

<400>  473

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ile His Leu Pro 
            100 


<210>  474
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  474
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgc                                                               69


<210>  475
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  475

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  476
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  476
aagtctagtc agagcctcct gcatagtgat ggaaagacct atttsgtat                   49


<210>  477
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  477

Lys Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  478
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable framework region 2 (FWR2) 
       sequence

<400>  478
tggtacctgc agaagccagg ccagtctcca cagctcctga tctat                       45


<210>  479
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable framework region 2 (FWR2) 
       sequence

<400>  479

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  480
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  480
gaagtttcca gccggttc                                                     18


<210>  481
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  481

Glu Val Ser Ser Arg Phe Ser 
1               5           


<210>  482
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable framework region 3 (FWR3) 
       sequence

<400>  482
ggagtgccag ataggttcag tggcagcggg tcagggacag atttcacact gaaaatcagc       60

cgggtggagg ctgaggatgt tggggtttat tactgc                                 96


<210>  483
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable framework region 3 (FWR3) 
       sequence

<400>  483

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  484
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable complementarity determining 
       regions3 (CDR3) sequence

<400>  484
atgcaaggta tacaccttcc t                                                 21


<210>  485
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV2-29*03 light chain variable complementarity determining 
       regions3 (CDR3) sequence

<400>  485

Met Gln Gly Ile His Leu Pro 
1               5           


<210>  486
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable region sequence

<400>  486
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca ggtctagtca gaccattgtc catagtaatg gaaacaccta tttggagtgg      120

tacctgcaga agccaggcca gtctccacag ctcctgatct ataaggtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgct tccaaggtag ccacgtgcct      300

ttcaccttcg gcggagggac caaggtggag atcaaacgaa ct                         342


<210>  487
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable region sequence

<400>  487

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr 
        


<210>  488
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  488
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgc                                                               69


<210>  489
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  489

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  490
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  490
ggtctagtca gaccattgtc catagtaatg gaaacaccta tttggag                     47


<210>  491
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  491

Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  492
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable framework region 2 (FWR2) acid 
       sequence

<400>  492
tggtacctgc agaagccagg ccagtctcca cagctcctga tctat                       45


<210>  493
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable framework region 2 (FWR2) acid 
       sequence

<400>  493

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  494
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  494
aaggtttcca accggttctc t                                                 21


<210>  495
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  495

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  496
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable framework region 3 (FWR3) acid 
       sequence

<400>  496
ggagtgccag ataggttcag tggcagcggg tcagggacag atttcacact gaaaatcagc       60

cgggtggagg ctgaggatgt tggggtttat tactgc                                 96


<210>  497
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable framework region 3 (FWR3) acid 
       sequence

<400>  497

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  498
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  498
ttccaaggta gccacgtgcc tttcacc                                           27


<210>  499
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  499

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  500
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 lambda light chain  sequence

<400>  500
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca ggtctagtca gaccattgtc catagtaatg gaaacaccta tttggagtgg      120

tacctgcaga agccaggcca gtctccacag ctcctgatct ataaggtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgct tccaaggtag ccacgtgcct      300

ttcaccttcg gcggagggac caaggtggag atcaaacgaa ctggtcagcc caaggctgcc      360

ccctcggtca ctctgttccc gccctcctct gaggagcttc aagccaacaa ggccacactg      420

gtgtgtctca taagtgactt ctacccggga gccgtgacag tggcctggaa ggcagatagc      480

agccccgtca aggcgggagt ggagaccacc acaccctcca aacaaagcaa caacaagtac      540

gcggccagca gctatctgag cctgacgcct gagcagtgga agtcccacag aagctacagc      600

tgccaggtca cgcatgaagg gagcaccgtg gagaagacag tggcccctac agaatgttca      660

tagtaa                                                                 666


<210>  501
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 lambda light chain  sequence

<400>  501

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
        115                 120                 125             


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
    130                 135                 140                 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
145                 150                 155                 160 


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
                165                 170                 175     


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
            180                 185                 190         


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
        195                 200                 205             


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215                 220 


<210>  502
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 Kappa light chain

<400>  502
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca ggtctagtca gaccattgtc catagtaatg gaaacaccta tttggagtgg      120

tacctgcaga agccaggcca gtctccacag ctcctgatct ataaggtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgct tccaaggtag ccacgtgcct      300

ttcaccttcg gcggagggac caaggtggag atcaaacgaa ctacggtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660

tagtaa                                                                 666


<210>  503
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 Kappa light chain

<400>  503

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  504
<211>  815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 Kappa light gBLOCK sequence

<400>  504
agctggctag gtaagcttgg taccgagctc ggatccacgc caccatggag acagacacac       60

tcctgctatg ggtactgctg ctctgggttc caggttccac tggtgacgat attgtgatga      120

cccagactcc actctctctg tccgtcaccc ctggacagcc ggcctccatc tcctgcaggt      180

ctagtcagac cattgtccat agtaatggaa acacctattt ggagtggtac ctgcagaagc      240

caggccagtc tccacagctc ctgatctata aggtttccaa ccggttctct ggagtgccag      300

ataggttcag tggcagcggg tcagggacag atttcacact gaaaatcagc cgggtggagg      360

ctgaggatgt tggggtttat tactgcttcc aaggtagcca cgtgcctttc accttcggcg      420

gagggaccaa ggtggagatc aaacgaacta cggtggctgc accatctgtc ttcatcttcc      480

cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact      540

tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact      600

cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc      660

tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc      720

agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag taagtttaaa      780

cccgctgatc agcctcgact gtgccttcta gttgc                                 815


<210>  505
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable region sequence

<400>  505
gaagtgatgg tcgtggaaag cggcggtggt ctggtaaagc cggggggatc ccttaagctt       60

tcttgcgccg catccgggtt cacgttctcc ggctatgcca tgtcctgggt ccgacagact      120

cccgaaaagc gcttggaatg ggtggccact atctcctccg gggggacgta catctactac      180

cccgacagtg tgaaaggaag atttacaata tctcgcgaca acgcaaaaaa taccttgtat      240

cttcaaatga gctccctgcg gtcagaggac actgccatgt actattgcgc ccgcctgggc      300

ggcgacaatt actatgagta t                                                321


<210>  506
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable region sequence

<400>  506

Glu Val Met Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
            100                 105         


<210>  507
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable complementarity determining region 
       1 (CDR1) sequence

<400>  507
ggctatgcca tgtcc                                                        15


<210>  508
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable complementarity determining region 
       1 (CDR1) sequence

<400>  508

Gly Tyr Ala Met Ser 
1               5   


<210>  509
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable complementarity determining region 
       2 (CDR2) sequence

<400>  509
actatctcct ccggggggac gtacatctac taccccgaca gtgtgaaagg a                51


<210>  510
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable complementarity determining region 
       2 (CDR2) sequence

<400>  510

Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  511
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable complementarity determining region 
       3 (CDR3) sequence

<400>  511
ctgggcggcg acaattacta tgagtat                                           27


<210>  512
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable complementarity determining region 
       3 (CDR3) sequence

<400>  512

Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
1               5                   


<210>  513
<211>  292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable region sequence

<400>  513
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc ga              292


<210>  514
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable region sequence

<400>  514

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  515
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  515
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt                                        90


<210>  516
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  516

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  517
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  517
agctatagca tgaac                                                        15


<210>  518
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  518

Ser Tyr Ser Met Asn 
1               5   


<210>  519
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  519
tgggtccgcc aggctccagg gaaggggctg gagtgggtc                              39


<210>  520
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  520

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10              


<210>  521
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  521
tcatccatta gtagtagtag tagttacata tactacgcag actcagtgaa gggc             54


<210>  522
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  522

Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  523
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  523
cgattcacca tctccagaga caacgccaag aactcactgt atctgcaaat gaacagcctg       60

agagccgagg acacggccgt gtattactgt gcga                                   94


<210>  524
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV3-21*04 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  524

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  525
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable region sequence

<400>  525
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cctgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagactgggc      300

ggcgataact attatgaata ttggggcaaa gggaccacgg tcaccgtctc ctcc            354


<210>  526
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable region sequence

<400>  526

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  527
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  527
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt                                        90


<210>  528
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  528

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  529
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable complementarity determining 
       region 1 (CDR1) sequence

<400>  529
ggctatgcca tgagc                                                        15


<210>  530
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable complementarity determining 
       region 1 (CDR1) sequence

<400>  530

Gly Tyr Ala Met Ser 
1               5   


<210>  531
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  531
tgggtccgcc aggctccagg gaaggggctg gagtgggtct ca                          42


<210>  532
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  532

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  533
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable complementarity determining 
       region 2 (CDR2) sequence

<400>  533
accattagta gtggcggaac ctacatatac taccctgact cagtgaaggg c                51


<210>  534
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable complementarity determining 
       region 2 (CDR2) sequence

<400>  534

Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  535
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  535
cgattcacca tctccagaga caacgccaag aactcactgt atctgcaaat gaacagcctg       60

agagccgagg acacggccgt gtattactgt gcgaga                                 96


<210>  536
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  536

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  537
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable complementarity determining 
       region 3 (CDR3) sequence

<400>  537
ctgggcggcg ataactatta tgaatat                                           27


<210>  538
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable complementarity determining 
       region 3 (CDR3) sequence

<400>  538

Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
1               5                   


<210>  539
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 IgG1 heavy chain sequence

<400>  539
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cctgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagactgggc      300

ggcgataact attatgaata ttggggcaaa gggaccacgg tcaccgtctc ctccgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gacagtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatgataa                                      1350


<210>  540
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 IgG1 heavy chain sequence

<400>  540

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  541
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 IgG2 heavy chain sequence

<400>  541
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cctgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagactgggc      300

ggcgataact attatgaata ttggggcaaa gggaccacgg tcaccgtctc ctccgcctcc      360

accaagggcc catcggtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      420

gccgccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgctc tgaccagcgg cgtgcacacc ttcccagctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcaact tcggcaccca gacctacacc      600

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agacagttga gcgcaaatgt      660

tgtgtcgagt gcccaccgtg cccagcacca cctgtggcag gaccgtcagt cttcctcttc      720

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      780

gtggacgtga gccacgaaga ccccgaggtc cagttcaact ggtacgtgga cggcgtggag      840

gtgcataatg ccaagacaaa gccacgggag gagcagttca acagcacgtt ccgtgtggtc      900

agcgtcctca ccgttgtgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc      960

tccaacaaag gcctcccagc ccccatcgag aaaaccatct ccaaaaccaa agggcagccc     1020

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc     1080

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc     1140

aatgggcagc cggagaacaa ctacaagacc acacctccca tgctggactc cgacggctcc     1200

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1260

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1320

tctccgggta aatagtaa                                                   1338


<210>  542
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 IgG2 heavy chain sequence

<400>  542

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  543
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable region sequence

<400>  543
gacatcgtca ttacgcagac ccctgccagt cttgccgttt ctctgggcca gagggccact       60

atcagttaca gggcgagtaa gtctgtgagt accagcggct atagttacat gcattggaac      120

cagcagaaac cgggacagcc accacgcctg cttatttatc tggtgtctaa tcttgagtcc      180

ggggtgcccg ccaggttcag cggcagcggc tctgggaccg acttcacact caacattcat      240

ccagtggaag aagaggacgc tgctacatac tactgtcaac acattcggga actgaccagg      300

agtgaa                                                                 306


<210>  544
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable region sequence

<400>  544

Asp Ile Val Ile Thr Gln Thr Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu 
            100         


<210>  545
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable complementarity determining region 
       1 (CDR1) sequence

<400>  545
agggcgagta agtctgtgag taccagcggc tatagttaca tgcat                       45


<210>  546
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable complementarity determining region 
       1 (CDR1) sequence

<400>  546

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  547
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable complementarity determining region 
       2 (CDR2) sequence

<400>  547
ctggtgtcta atcttgagtc c                                                 21


<210>  548
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable complementarity determining region 
       2 (CDR2) sequence

<400>  548

Leu Val Ser Asn Leu Glu Ser 
1               5           


<210>  549
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable complementarity determining region 
       3 (CDR3) sequence

<400>  549
caacacattc gggaactgac caggagtgaa                                        30


<210>  550
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable complementarity determining region 
       3 (CDR3) sequence

<400>  550

Gln His Ile Arg Glu Leu Thr Arg Ser Glu 
1               5                   10  


<210>  551
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable region sequence

<400>  551
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

cct                                                                    303


<210>  552
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable region sequence

<400>  552

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro 
            100     


<210>  553
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable framework region 1 
       (FWR1) acid sequence

<400>  553
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgc                                                               69


<210>  554
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable framework region 1 
       (FWR1) acid sequence

<400>  554

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  555
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  555
aagtccagcc agagtgtttt atacagctcc aacaataaga actacttagc t                51


<210>  556
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  556

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  557
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable framework region 2 
       (FWR2) sequence

<400>  557
tggtaccagc agaaaccagg acagcctcct aagctgctca tttac                       45


<210>  558
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable framework region 2 
       (FWR2) sequence

<400>  558

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  559
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  559
tgggcatcta cccgggaatc c                                                 21


<210>  560
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  560

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  561
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable framework region 3 
       (FWR3) sequence

<400>  561
ggggtccctg accgattcag tggcagcggg tctgggacag atttcactct caccatcagc       60

agcctgcagg ctgaagatgt ggcagtttat tactgt                                 96


<210>  562
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable framework region 3 
       (FWR3) sequence

<400>  562

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  563
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable complementarity 
       determining regions3 (CDR3) sequence

<400>  563
cagcaatatt atagtactcc t                                                 21


<210>  564
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NCBI germline z00023 light chain variable complementarity 
       determining regions3 (CDR3) sequence

<400>  564

Gln Gln Tyr Tyr Ser Thr Pro 
1               5           


<210>  565
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable region sequence

<400>  565
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca gggccagcaa gagtgttagc accagcggct acagctacat gcactggtac      120

cagcagaaac caggacagcc tcctaagctg ctcatttacc tggtgtctaa cctggaatcc      180

ggggtccctg accgattcag tggcagcggg tctgggacag atttcactct caccatcagc      240

agcctgcagg ctgaagatgt ggcagtttat tactgtcaac acattcggga actgaccagg      300

agtgaattcg gcggagggac caaggtggag atcaaacgaa ct                         342


<210>  566
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable region sequence

<400>  566

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr 
        


<210>  567
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable framework region 1 (FWR1) 
       sequence

<400>  567
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgc                                                               69


<210>  568
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable framework region 1 (FWR1) 
       sequence

<400>  568

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  569
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable complementarity determining 
       region 1 (CDR1) sequence

<400>  569
agggccagca agagtgttag caccagcggc tacagctaca tg                          42


<210>  570
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable complementarity determining 
       region 1 (CDR1) sequence

<400>  570

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met 
1               5                   10                  


<210>  571
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable framework region 2 (FWR2) 
       sequence

<400>  571
cactggtacc agcagaaacc aggacagcct cctaagctgc tcatttac                    48


<210>  572
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable framework region 2 (FWR2) 
       sequence

<400>  572

His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15      


<210>  573
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable complementarity determining 
       region 2 (CDR2) sequence

<400>  573
ctggtgtcta acctggaatc c                                                 21


<210>  574
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable complementarity determining 
       region 2 (CDR2) sequence

<400>  574

Leu Val Ser Asn Leu Glu Ser 
1               5           


<210>  575
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable framework region 3 (FWR3) 
       sequence

<400>  575
ggggtccctg accgattcag tggcagcggg tctgggacag atttcactct caccatcagc       60

agcctgcagg ctgaagatgt ggcagtttat tactgt                                 96


<210>  576
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable framework region 3 (FWR3) 
       sequence

<400>  576

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  577
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable complementarity determining 
       region 3 (CDR3) sequence

<400>  577
caacacattc gggaactgac caggagtgaa                                        30


<210>  578
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable complementarity determining 
       region 3 (CDR3) sequence

<400>  578

Gln His Ile Arg Glu Leu Thr Arg Ser Glu 
1               5                   10  


<210>  579
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 Lambda light chain sequence

<400>  579
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca gggccagcaa gagtgttagc accagcggct acagctacat gcactggtac      120

cagcagaaac caggacagcc tcctaagctg ctcatttacc tggtgtctaa cctggaatcc      180

ggggtccctg accgattcag tggcagcggg tctgggacag atttcactct caccatcagc      240

agcctgcagg ctgaagatgt ggcagtttat tactgtcaac acattcggga actgaccagg      300

agtgaattcg gcggagggac caaggtggag atcaaacgaa ctggtcagcc caaggctgcc      360

ccctcggtca ctctgttccc gccctcctct gaggagcttc aagccaacaa ggccacactg      420

gtgtgtctca taagtgactt ctacccggga gccgtgacag tggcctggaa ggcagatagc      480

agccccgtca aggcgggagt ggagaccacc acaccctcca aacaaagcaa caacaagtac      540

gcggccagca gctatctgag cctgacgcct gagcagtgga agtcccacag aagctacagc      600

tgccaggtca cgcatgaagg gagcaccgtg gagaagacag tggcccctac agaatgttca      660

tagtaa                                                                 666


<210>  580
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 Lambda light chain sequence

<400>  580

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
        115                 120                 125             


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
    130                 135                 140                 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
145                 150                 155                 160 


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
                165                 170                 175     


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
            180                 185                 190         


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
        195                 200                 205             


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215                 220 


<210>  581
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 Kappa light chain sequence

<400>  581
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca gggccagcaa gagtgttagc accagcggct acagctacat gcactggtac      120

cagcagaaac caggacagcc tcctaagctg ctcatttacc tggtgtctaa cctggaatcc      180

ggggtccctg accgattcag tggcagcggg tctgggacag atttcactct caccatcagc      240

agcctgcagg ctgaagatgt ggcagtttat tactgtcaac acattcggga actgaccagg      300

agtgaattcg gcggagggac caaggtggag atcaaacgaa ctacggtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660

tagtaa                                                                 666


<210>  582
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 Kappa light chain sequence

<400>  582

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  583
<211>  815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 Kappa light chain gBLOCk sequence

<400>  583
agctggctag gtaagcttgg taccgagctc ggatccacgc caccatggag acagacacac       60

tcctgctatg ggtactgctg ctctgggttc caggttccac tggtgacgac atcgtgatga      120

cccagtctcc agactccctg gctgtgtctc tgggcgagag ggccaccatc aactgcaggg      180

ccagcaagag tgttagcacc agcggctaca gctacatgca ctggtaccag cagaaaccag      240

gacagcctcc taagctgctc atttacctgg tgtctaacct ggaatccggg gtccctgacc      300

gattcagtgg cagcgggtct gggacagatt tcactctcac catcagcagc ctgcaggctg      360

aagatgtggc agtttattac tgtcaacaca ttcgggaact gaccaggagt gaattcggcg      420

gagggaccaa ggtggagatc aaacgaacta cggtggctgc accatctgtc ttcatcttcc      480

cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact      540

tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact      600

cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc      660

tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc      720

agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag taagtttaaa      780

cccgctgatc agcctcgact gtgccttcta gttgc                                 815


<210>  584
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD8 sequence

<400>  584
gaggtccagc tggttgagag tggcggtggg ctggttaagc ctggcggctc cctgcggctg       60

agctgcgccg cgagtggatt tactttcagc cgatatggga tgagttgggt gcggcaagct      120

cccgggaaga ggctggaatg ggtctcaaca atctccgggg ggggcactta catctattac      180

cccgactcag tcaaggggag atttaccatt tcacgagaca acgctaagaa taccctgtat      240

ttgcagatga attctctgag agcagaggac acagctgttt actattgtac ccgcgacaac      300

tatggcagga actacgacta cggtatggac tattggggac aagggacatt ggttacagtg      360

agcagtggcg gcgggggcag cggaggagga ggcagcggtg gggggggcag cgagatagtg      420

ctcacgcagt cacccgcgac tctcagtctc tcacctgggg aacgagctac cctgacgtgc      480

tctgctacct cctcagtgtc atatattcac tggtatcagc aacggcccgg gcagtcccct      540

agattgctca tttatagtac ctctaatctg gcctcaggta tccctgcacg attttctgga      600

tctggttcag gttctgatta caccctcact atctctagcc tggagcctga agactttgcc      660

gtttattact gccagcagag gtctagctcc ccattcacct ttgggagtgg gaccaaggtt      720

gaaattaaaa cgacaacccc ggcccccaga ccaccaacgc cagcccccac catcgccagc      780

caacccctgt ctctgagacc agaagcctgt aggcctgccg ccggtggagc tgtgcacaca      840

agaggactgg atttcgcctg tgatatctac atttgggccc cgctcgcagg cacatgtgga      900

gtgctcctcc tctccctggt gattaccctg tactgctgat aa                         942


<210>  585
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD8 sequence

<400>  585

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro 
                165                 170                 175     


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    290                 295                 300                 


Ser Leu Val Ile Thr Leu Tyr Cys 
305                 310         


<210>  586
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD8 sequence

<400>  586
gaagtgcagc tcgtagagag tggcggggga ctggtgaagc ccggtggaag cctcagactc       60

agttgcgccg cctcaggttt cactttttca ggttacgcca tgtcctgggt aagacaggca      120

ccggggaaag gactcgagtg ggtgtctact atcagctcag gaggcactta tatatattat      180

cctgactctg taaaaggccg atttacgatt tctcgcgaca atgcaaagaa ctccctctac      240

ctccaaatga acagtcttag ggcagaagac actgctgtat actattgtgc acgcctcggc      300

ggcgacaact actacgagta ctttgacgtg tgggggaaag ggactaccgt gacagtttca      360

agcggaggag gtggctcagg tggaggcggg tcaggggggg gaggaagtga tattgtgctc      420

acacaatccc cagcctccct ggctgtgtct cccggccaac gcgctacaat tacatgtcgg      480

gcctccaaaa gcgtgagcac cagcggctac agctacatgc actggtatca acagaaacca      540

ggacaacccc ccaaactgtt gatttatctc gcttcaaact tggagtccgg cgtgcctgcg      600

cgcttttcag ggagtgggag cggcacagat tttacgctga ctatcaaccc cgtagaagca      660

aacgatacag cgaattatta ttgtcaacat tcccgggaac tcccctttac gttcggcggg      720

ggcacaaagg tcgaaattaa gagaaccacg acaaccccgg cccccagacc accaacgcca      780

gcccccacca tcgccagcca acccctgtct ctgagaccag aagcctgtag gcctgccgcc      840

ggtggagctg tgcacacaag aggactggat ttcgcctgtg atatctacat ttgggccccg      900

ctcgcaggca catgtggagt gctcctcctc tccctggtga ttaccctgta ctgctgataa      960


<210>  587
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD8 sequence

<400>  587

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Thr Pro Ala Pro Arg 
                245                 250                 255     


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
            260                 265                 270         


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
        275                 280                 285             


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
    290                 295                 300                 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
305                 310                 315             


<210>  588
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8/4-1BB sequence

<400>  588
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgatatcta catttgggcc ccgctcgcag gcacatgtgg agtgctcctc      180

ctctccctgg tgattaccct gtactgcaaa aggggccgca aaaaactcct ttacattttt      240

aagcagcctt ttatgaggcc agtacagacg actcaagagg aagacgggtg ctcatgccgc      300

tttcctgagg aggaggaagg agggtgcgaa ctgtgataa                             339


<210>  589
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8/4-1BB sequence

<400>  589

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
65                  70                  75                  80  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                85                  90                  95      


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            100                 105                 110     


<210>  590
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8/CD28 sequence

<400>  590
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgatatcta catttgggcc ccgctcgcag gcacatgtgg agtgctcctc      180

ctctccctgg tgattaccct gtactgcaga agcaagcggt ctcggctcct gcattctgat      240

tacatgaaca tgaccccaag aagaccaggc cccaccagga aacattacca gccctacgct      300

ccgccacgcg acttcgctgc ctaccggtcc tgataa                                336


<210>  591
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8/CD28 sequence

<400>  591

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105                 110 


<210>  592
<211>  549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8/CD3z sequence

<400>  592
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgatatcta catttgggcc ccgctcgcag gcacatgtgg agtgctcctc      180

ctctccctgg tgattaccct gtactgccgc gttaagttct cccgatcagc cgacgcgcct      240

gcttacaagc agggccagaa ccaactgtac aacgagctga atctcggtag acgggaagag      300

tacgacgtgt tggacaaacg gagaggccgc gacccagaaa tgggcggcaa gcctcgcagg      360

aaaaaccccc aggagggact gtacaatgag ttgcagaaag ataagatggc agaagcttat      420

agcgagatcg gaatgaaggg ggaaaggaga cgagggaaag gacacgacgg cctttatcag      480

ggcctgtcca cagcaacaaa agatacgtat gacgccctcc atatgcaggc acttccacca      540

cggtgataa                                                              549


<210>  593
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8/CD3z sequence

<400>  593

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
65                  70                  75                  80  


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                85                  90                  95      


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            100                 105                 110         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        115                 120                 125             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    130                 135                 140                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
145                 150                 155                 160 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                165                 170                 175     


Ala Leu Pro Pro Arg 
            180     


<210>  594
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8/CD28/CD3z sequence

<400>  594
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgatatcta catttgggcc ccgctcgcag gcacatgtgg agtgctcctc      180

ctctccctgg tgattaccct gtactgcaga agcaagcggt ctcggctcct gcattctgat      240

tacatgaaca tgaccccaag aagaccaggc cccaccagga aacattacca gccctacgct      300

ccgccacgcg acttcgctgc ctaccggtcc cgcgttaagt tctcccgatc agccgacgcg      360

cctgcttaca agcagggcca gaaccaactg tacaacgagc tgaatctcgg tagacgggaa      420

gagtacgacg tgttggacaa acggagaggc cgcgacccag aaatgggcgg caagcctcgc      480

aggaaaaacc cccaggaggg actgtacaat gagttgcaga aagataagat ggcagaagct      540

tatagcgaga tcggaatgaa gggggaaagg agacgaggga aaggacacga cggcctttat      600

cagggcctgt ccacagcaac aaaagatacg tatgacgccc tccatatgca ggcacttcca      660

ccacggtgat aa                                                          672


<210>  595
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8/CD28/CD3z sequence

<400>  595

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            100                 105                 110         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        115                 120                 125             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    130                 135                 140                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
145                 150                 155                 160 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                165                 170                 175     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            180                 185                 190         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        195                 200                 205             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220         


<210>  596
<211>  675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8/4-1BB/CD3z sequence

<400>  596
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgatatcta catttgggcc ccgctcgcag gcacatgtgg agtgctcctc      180

ctctccctgg tgattaccct gtactgcaaa aggggccgca aaaaactcct ttacattttt      240

aagcagcctt ttatgaggcc agtacagacg actcaagagg aagacgggtg ctcatgccgc      300

tttcctgagg aggaggaagg agggtgcgaa ctgcgcgtta agttctcccg atcagccgac      360

gcgcctgctt acaagcaggg ccagaaccaa ctgtacaacg agctgaatct cggtagacgg      420

gaagagtacg acgtgttgga caaacggaga ggccgcgacc cagaaatggg cggcaagcct      480

cgcaggaaaa acccccagga gggactgtac aatgagttgc agaaagataa gatggcagaa      540

gcttatagcg agatcggaat gaagggggaa aggagacgag ggaaaggaca cgacggcctt      600

tatcagggcc tgtccacagc aacaaaagat acgtatgacg ccctccatat gcaggcactt      660

ccaccacggt gataa                                                       675


<210>  597
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8/4-1BB/CD3z sequence

<400>  597

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
65                  70                  75                  80  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                85                  90                  95      


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            100                 105                 110         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
        115                 120                 125             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    130                 135                 140                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
145                 150                 155                 160 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                165                 170                 175     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            180                 185                 190         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        195                 200                 205             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220             


<210>  598
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8/CD28/4-1BB/CD3z sequence

<400>  598
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgatatcta catttgggcc ccgctcgcag gcacatgtgg agtgctcctc      180

ctctccctgg tgattaccct gtactgcaga agcaagcggt ctcggctcct gcattctgat      240

tacatgaaca tgaccccaag aagaccaggc cccaccagga aacattacca gccctacgct      300

ccgccacgcg acttcgctgc ctaccggtcc aaaaggggcc gcaaaaaact cctttacatt      360

tttaagcagc cttttatgag gccagtacag acgactcaag aggaagacgg gtgctcatgc      420

cgctttcctg aggaggagga aggagggtgc gaactgcgcg ttaagttctc ccgatcagcc      480

gacgcgcctg cttacaagca gggccagaac caactgtaca acgagctgaa tctcggtaga      540

cgggaagagt acgacgtgtt ggacaaacgg agaggccgcg acccagaaat gggcggcaag      600

cctcgcagga aaaaccccca ggagggactg tacaatgagt tgcagaaaga taagatggca      660

gaagcttata gcgagatcgg aatgaagggg gaaaggagac gagggaaagg acacgacggc      720

ctttatcagg gcctgtccac agcaacaaaa gatacgtatg acgccctcca tatgcaggca      780

cttccaccac ggtgataa                                                    798


<210>  599
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8/CD28/4-1BB/CD3z sequence

<400>  599

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg 
            100                 105                 110         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        115                 120                 125             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    130                 135                 140                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
145                 150                 155                 160 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                165                 170                 175     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            180                 185                 190         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        195                 200                 205             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    210                 215                 220                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
225                 230                 235                 240 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                245                 250                 255     


His Met Gln Ala Leu Pro Pro Arg 
            260                 


<210>  600
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C3 4-1BB/CD3z sequence

<400>  600
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccacaggttc agctggtgca gtctggagct gaggtgaaga agcctggggc ctcagtgaag      120

gtctcctgca aggcttctgg ttacaccttt accgactacg ccatgaactg ggtgcgacag      180

gcccctggac aagggcttga gtggatggga gtgatcagca ccttcagcgg taacacaaac      240

ttcaaccaga agttcaaggg cagagtcacc atgaccacag acacatccac gagcacagcc      300

tacatggagc tgaggagcct gagatctgac gacacggccg tgtattactg tgcgagaagc      360

gactactacg gcccatactt cgactactgg ggccagggca ccaccctgac cgtgtccagc      420

ggcggtggcg gatccggcgg tggcggatcc ggcggtggcg gatccgatat tgtgatgacc      480

cagactccac tctctctgtc cgtcacccct ggacagccgg cctccatctc ctgcaggtct      540

agtcagacca ttgtccatag taatggaaac acctatttgg agtggtacct gcagaagcca      600

ggccagtctc cacagctcct gatctataag gtttccaacc ggttctctgg agtgccagat      660

aggttcagtg gcagcgggtc agggacagat ttcacactga aaatcagccg ggtggaggct      720

gaggatgttg gggtttatta ctgcttccaa ggtagccacg tgcctttcac cttcggcgga      780

gggaccaagg tggagatcaa acgaactacg acaaccccgg cccccagacc accaacgcca      840

gcccccacca tcgccagcca acccctgtct ctgagaccag aagcctgtag gcctgccgcc      900

ggtggagctg tgcacacaag aggactggat ttcgcctgtg atatctacat ttgggccccg      960

ctcgcaggca catgtggagt gctcctcctc tccctggtga ttaccctgta ctgcaaaagg     1020

ggccgcaaaa aactccttta catttttaag cagcctttta tgaggccagt acagacgact     1080

caagaggaag acgggtgctc atgccgcttt cctgaggagg aggaaggagg gtgcgaactg     1140

cgcgttaagt tctcccgatc agccgacgcg cctgcttaca agcagggcca gaaccaactg     1200

tacaacgagc tgaatctcgg tagacgggaa gagtacgacg tgttggacaa acggagaggc     1260

cgcgacccag aaatgggcgg caagcctcgc aggaaaaacc cccaggaggg actgtacaat     1320

gagttgcaga aagataagat ggcagaagct tatagcgaga tcggaatgaa gggggaaagg     1380

agacgaggga aaggacacga cggcctttat cagggcctgt ccacagcaac aaaagatacg     1440

tatgacgccc tccatatgca ggcacttcca ccacggtgat aa                        1482


<210>  601
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C3 4-1BB/CD3z sequence

<400>  601

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 


Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Thr Pro Ala Pro Arg Pro 
                245                 250                 255     


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            260                 265                 270         


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        275                 280                 285             


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    290                 295                 300                 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
305                 310                 315                 320 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 


Met Gln Ala Leu Pro Pro Arg 
465                 470     


<210>  602
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C3 CAR gBLOCK 1 sequence

<400>  602
atccacgctg ttttgacctc catagaagat tctagagcta gctgtagagc ttggtaccga       60

gggccaccat ggccctgccc gtgaccgctt tgctgctccc cctggcgctg ctgctgcacg      120

ccgccaggcc acaggttcag ctggtgcagt ctggagctga ggtgaagaag cctggggcct      180

cagtgaaggt ctcctgcaag gcttctggtt acacctttac cgactacgcc atgaactggg      240

tgcgacaggc ccctggacaa gggcttgagt ggatgggagt gatcagcacc ttcagcggta      300

acacaaactt caaccagaag ttcaagggca gagtcaccat gaccacagac acatccacga      360

gcacagccta catggagctg aggagcctga gatctgacga cacggccgtg tattactgtg      420

cgagaagcga ctactacggc ccatacttcg actactgggg ccagggcacc accctgaccg      480

tgtccagcgg cggtggcgga tccggcggtg gcggatccgg cggtggcgga tccgatattg      540

tgatgaccca gactccactc tctctgt                                          567


<210>  603
<211>  509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C3 CAR gBLOCK 2 sequence

<400>  603
tattgtgatg acccagactc cactctctct gtccgtcacc cctggacagc cggcctccat       60

ctcctgcagg tctagtcaga ccattgtcca tagtaatgga aacacctatt tggagtggta      120

cctgcagaag ccaggccagt ctccacagct cctgatctat aaggtttcca accggttctc      180

tggagtgcca gataggttca gtggcagcgg gtcagggaca gatttcacac tgaaaatcag      240

ccgggtggag gctgaggatg ttggggttta ttactgcttc caaggtagcc acgtgccttt      300

caccttcggc ggagggacca aggtggagat caaacgaact acgacaaccc cggcccccag      360

accaccaacg ccagccccca ccatcgccag ccaacccctg tctctgagac cagaagcctg      420

taggcctgcc gccggtggag ctgtgcacac aagaggactg gatttcgcct gtgatatcta      480

catttgggcc ccgctcgcag gcacatgtg                                        509


<210>  604
<211>  455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 scFV gBLOCK 1 sequence

<400>  604
tgctctgggt tccaggttcc actggtgacg cggcccagcc ggccgaggtg cagctggtgg       60

agtctggggg aggcctggtc aagcctgggg ggtccctgag actctcctgt gcagcctctg      120

gattcacctt cagtaggtat ggcatgagct gggtccgcca ggctccaggg aagaggctgg      180

agtgggtctc aaccattagt ggcggaggca cctacatata ctacccagac tcagtgaagg      240

gccgattcac catctccaga gacaacgcca agaacaccct gtatctgcaa atgaacagcc      300

tgagagccga ggacacggct gtgtattact gtaccagaga taactatggc cgcaactatg      360

attatggcat ggattattgg ggccagggca ccctggtgac cgtgagcagc ggcggtggcg      420

gatccggcgg tggcggatcc ggcggtggcg gatcc                                 455


<210>  605
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 scFV gBLOCK 2 sequence

<400>  605
ggcggtggcg gatccggcgg tggcggatcc ggcggtggcg gatccgaaat tgtgttgaca       60

cagtctccag ccaccctgtc tttgtctcca ggggaaagag ccaccctcac ctgcagcgcc      120

accagcagtg ttagctacat ccactggtac caacagaggc ctggccagag ccccaggctc      180

ctcatctata gcacctccaa cctggccagc ggcatcccag ccaggttcag tggcagtggg      240

tctgggagcg actacactct caccatcagc agcctagagc ctgaagattt tgcagtttat      300

tactgtcagc agcgtagcag ctcccctttc acctttggca gcggcaccaa agtggaaatt      360

aaaaccggtc atcatcacca tcaccactga taagtttaaa cccgctgatc agcctcgact      420

gtgccttcta gt                                                          432


<210>  606
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD3z sequence

<400>  606
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc acgacaaccc cggcccccag accaccaacg      840

ccagccccca ccatcgccag ccaacccctg tctctgagac cagaagcctg taggcctgcc      900

gccggtggag ctgtgcacac aagaggactg gatttcgcct gtgatatcta catttgggcc      960

ccgctcgcag gcacatgtgg agtgctcctc ctctccctgg tgattaccct gtactgccgc     1020

gttaagttct cccgatcagc cgacgcgcct gcttacaagc agggccagaa ccaactgtac     1080

aacgagctga atctcggtag acgggaagag tacgacgtgt tggacaaacg gagaggccgc     1140

gacccagaaa tgggcggcaa gcctcgcagg aaaaaccccc aggagggact gtacaatgag     1200

ttgcagaaag ataagatggc agaagcttat agcgagatcg gaatgaaggg ggaaaggaga     1260

cgagggaaag gacacgacgg cctttatcag ggcctgtcca cagcaacaaa agatacgtat     1320

gacgccctcc atatgcaggc acttccacca cggtgataa                            1359


<210>  607
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD3z sequence

<400>  607

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            340                 345                 350         


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        355                 360                 365             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    370                 375                 380                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                405                 410                 415     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            420                 425                 430         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        435                 440                 445             


Pro Pro Arg 
    450     


<210>  608
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD28/CD3z sequence

<400>  608
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc acgacaaccc cggcccccag accaccaacg      840

ccagccccca ccatcgccag ccaacccctg tctctgagac cagaagcctg taggcctgcc      900

gccggtggag ctgtgcacac aagaggactg gatttcgcct gtgatatcta catttgggcc      960

ccgctcgcag gcacatgtgg agtgctcctc ctctccctgg tgattaccct gtactgcaga     1020

agcaagcggt ctcggctcct gcattctgat tacatgaaca tgaccccaag aagaccaggc     1080

cccaccagga aacattacca gccctacgct ccgccacgcg acttcgctgc ctaccggtcc     1140

cgcgttaagt tctcccgatc agccgacgcg cctgcttaca agcagggcca gaaccaactg     1200

tacaacgagc tgaatctcgg tagacgggaa gagtacgacg tgttggacaa acggagaggc     1260

cgcgacccag aaatgggcgg caagcctcgc aggaaaaacc cccaggaggg actgtacaat     1320

gagttgcaga aagataagat ggcagaagct tatagcgaga tcggaatgaa gggggaaagg     1380

agacgaggga aaggacacga cggcctttat cagggcctgt ccacagcaac aaaagatacg     1440

tatgacgccc tccatatgca ggcacttcca ccacggtgat aa                        1482


<210>  609
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD28/CD3z sequence

<400>  609

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  610
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 4-1BB/CD3z sequence

<400>  610
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc acgacaaccc cggcccccag accaccaacg      840

ccagccccca ccatcgccag ccaacccctg tctctgagac cagaagcctg taggcctgcc      900

gccggtggag ctgtgcacac aagaggactg gatttcgcct gtgatatcta catttgggcc      960

ccgctcgcag gcacatgtgg agtgctcctc ctctccctgg tgattaccct gtactgcaaa     1020

aggggccgca aaaaactcct ttacattttt aagcagcctt ttatgaggcc agtacagacg     1080

actcaagagg aagacgggtg ctcatgccgc tttcctgagg aggaggaagg agggtgcgaa     1140

ctgcgcgtta agttctcccg atcagccgac gcgcctgctt acaagcaggg ccagaaccaa     1200

ctgtacaacg agctgaatct cggtagacgg gaagagtacg acgtgttgga caaacggaga     1260

ggccgcgacc cagaaatggg cggcaagcct cgcaggaaaa acccccagga gggactgtac     1320

aatgagttgc agaaagataa gatggcagaa gcttatagcg agatcggaat gaagggggaa     1380

aggagacgag ggaaaggaca cgacggcctt tatcagggcc tgtccacagc aacaaaagat     1440

acgtatgacg ccctccatat gcaggcactt ccaccacggt gataa                     1485


<210>  611
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 4-1BB/CD3z sequence

<400>  611

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  612
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 OX40/CD3z sequence

<400>  612
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc acgacaaccc cggcccccag accaccaacg      840

ccagccccca ccatcgccag ccaacccctg tctctgagac cagaagcctg taggcctgcc      900

gccggtggag ctgtgcacac aagaggactg gatttcgcct gtgatatcta catttgggcc      960

ccgctcgcag gcacatgtgg agtgctcctc ctctccctgg tgattaccct gtactgccgg     1020

agggaccaga ggctgccccc cgatgcccac aagccccctg ggggaggcag tttccggacc     1080

cccatccaag aggagcaggc cgacgcccac tccaccctgg ccaagatccg cgttaagttc     1140

tcccgatcag ccgacgcgcc tgcttacaag cagggccaga accaactgta caacgagctg     1200

aatctcggta gacgggaaga gtacgacgtg ttggacaaac ggagaggccg cgacccagaa     1260

atgggcggca agcctcgcag gaaaaacccc caggagggac tgtacaatga gttgcagaaa     1320

gataagatgg cagaagctta tagcgagatc ggaatgaagg gggaaaggag acgagggaaa     1380

ggacacgacg gcctttatca gggcctgtcc acagcaacaa aagatacgta tgacgccctc     1440

catatgcagg cacttccacc acggtgataa                                      1470


<210>  613
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 OX40/CD3z sequence

<400>  613

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
            340                 345                 350         


Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
        355                 360                 365             


Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  614
<211>  1593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD28/OX40/CD3z sequence

<400>  614
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc acgacaaccc cggcccccag accaccaacg      840

ccagccccca ccatcgccag ccaacccctg tctctgagac cagaagcctg taggcctgcc      900

gccggtggag ctgtgcacac aagaggactg gatttcgcct gtgatatcta catttgggcc      960

ccgctcgcag gcacatgtgg agtgctcctc ctctccctgg tgattaccct gtactgcaga     1020

agcaagcggt ctcggctcct gcattctgat tacatgaaca tgaccccaag aagaccaggc     1080

cccaccagga aacattacca gccctacgct ccgccacgcg acttcgctgc ctaccggtcc     1140

cggagggacc agaggctgcc ccccgatgcc cacaagcccc ctgggggagg cagtttccgg     1200

acccccatcc aagaggagca ggccgacgcc cactccaccc tggccaagat ccgcgttaag     1260

ttctcccgat cagccgacgc gcctgcttac aagcagggcc agaaccaact gtacaacgag     1320

ctgaatctcg gtagacggga agagtacgac gtgttggaca aacggagagg ccgcgaccca     1380

gaaatgggcg gcaagcctcg caggaaaaac ccccaggagg gactgtacaa tgagttgcag     1440

aaagataaga tggcagaagc ttatagcgag atcggaatga agggggaaag gagacgaggg     1500

aaaggacacg acggccttta tcagggcctg tccacagcaa caaaagatac gtatgacgcc     1560

ctccatatgc aggcacttcc accacggtga taa                                  1593


<210>  615
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD28/OX40/CD3z sequence

<400>  615

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Arg Asp Gln 
    370                 375                 380                 


Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg 
385                 390                 395                 400 


Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys 
                405                 410                 415     


Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            420                 425                 430         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        435                 440                 445             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    450                 455                 460                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
465                 470                 475                 480 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                485                 490                 495     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            500                 505                 510         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        515                 520                 525             


Arg 
    


<210>  616
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 OX40/CD3z sequence

<400>  616
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aaacgacaac cccggccccc agaccaccaa cgccagcccc caccatcgcc      840

agccaacccc tgtctctgag accagaagcc tgtaggcctg ccgccggtgg agctgtgcac      900

acaagaggac tggatttcgc ctgtgatatc tacatttggg ccccgctcgc aggcacatgt      960

ggagtgctcc tcctctccct ggtgattacc ctgtactgcc ggagggacca gaggctgccc     1020

cccgatgccc acaagccccc tgggggaggc agtttccgga cccccatcca agaggagcag     1080

gccgacgccc actccaccct ggccaagatc cgcgttaagt tctcccgatc agccgacgcg     1140

cctgcttaca agcagggcca gaaccaactg tacaacgagc tgaatctcgg tagacgggaa     1200

gagtacgacg tgttggacaa acggagaggc cgcgacccag aaatgggcgg caagcctcgc     1260

aggaaaaacc cccaggaggg actgtacaat gagttgcaga aagataagat ggcagaagct     1320

tatagcgaga tcggaatgaa gggggaaagg agacgaggga aaggacacga cggcctttat     1380

cagggcctgt ccacagcaac aaaagatacg tatgacgccc tccatatgca ggcacttcca     1440

ccacggtgat aa                                                         1452


<210>  617
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 OX40/CD3z sequence

<400>  617

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Arg Asp 
                325                 330                 335     


Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe 
            340                 345                 350         


Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala 
        355                 360                 365             


Lys Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  618
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD28/OX40/CD3z sequence

<400>  618
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aaacgacaac cccggccccc agaccaccaa cgccagcccc caccatcgcc      840

agccaacccc tgtctctgag accagaagcc tgtaggcctg ccgccggtgg agctgtgcac      900

acaagaggac tggatttcgc ctgtgatatc tacatttggg ccccgctcgc aggcacatgt      960

ggagtgctcc tcctctccct ggtgattacc ctgtactgca gaagcaagcg gtctcggctc     1020

ctgcattctg attacatgaa catgacccca agaagaccag gccccaccag gaaacattac     1080

cagccctacg ctccgccacg cgacttcgct gcctaccggt cccggaggga ccagaggctg     1140

ccccccgatg cccacaagcc ccctggggga ggcagtttcc ggacccccat ccaagaggag     1200

caggccgacg cccactccac cctggccaag atccgcgtta agttctcccg atcagccgac     1260

gcgcctgctt acaagcaggg ccagaaccaa ctgtacaacg agctgaatct cggtagacgg     1320

gaagagtacg acgtgttgga caaacggaga ggccgcgacc cagaaatggg cggcaagcct     1380

cgcaggaaaa acccccagga gggactgtac aatgagttgc agaaagataa gatggcagaa     1440

gcttatagcg agatcggaat gaagggggaa aggagacgag ggaaaggaca cgacggcctt     1500

tatcagggcc tgtccacagc aacaaaagat acgtatgacg ccctccatat gcaggcactt     1560

ccaccacggt gataa                                                      1575


<210>  619
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD28/OX40/CD3z sequence

<400>  619

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
    370                 375                 380                 


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
385                 390                 395                 400 


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser 
                405                 410                 415     


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
            420                 425                 430         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        435                 440                 445             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    450                 455                 460                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
465                 470                 475                 480 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                485                 490                 495     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            500                 505                 510         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520             


<210>  620
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC1 FRAGMENT

<400>  620

Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu 
1               5                   10                  15      


Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 
            20                  25                  30          


Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr 
        35                  40              


<210>  621
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC1 FRAGMENT

<400>  621

Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            20                  25                  30          


Ser Arg Tyr 
        35  


<210>  622
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytoplasmic MUC1 truncated segment

<400>  622

Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp 
1               5                   10                  15      


Val Glu Thr Gln Phe Asn Gln Tyr 
            20                  


<210>  623
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytoplasmic MUC1 truncated segment

<400>  623

Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu 
1               5                   10                  15      


Ala Phe Arg Glu Gly Thr Ile Asn 
            20                  


<210>  624
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  624
attctaagct tgggccacca tggaactg                                          28


<210>  625
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  625
tctagagttt aaacttacta tttacccgga gacagggaga g                           41


<210>  626
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  626
agtatggccc agccggccga ggtgcagctg gtggagtctg g                           41


<210>  627
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  627
tagaaggcac agtcgaggct gatcag                                            26


<210>  628
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  628
attctaagct tgggccacca tggaagc                                           27


<210>  629
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  629
tctagagttt aaacttacta acactctccc ctgttgaagc                             40


<210>  630
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  630
agtatggccc agccggccga aattgtgttg acacagtctc cag                         43


<210>  631
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  631
tagaaggcac agtcgaggct gatcag                                            26


<210>  632
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  632
actgtcatat ggaggtgcag ctggtggagt ctg                                    33


<210>  633
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  633
actgtctcga gtttaatttc cactttggtg ccgctgc                                37


<210>  634
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  634
actgtcatat ggaggtgcag ctggtggagt ctg                                    33


<210>  635
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  635
actgtaccgg ttttaatttc cactttggtg ccgctgc                                37


<210>  636
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  636
cttcttcctc aggagcaagc tcaccgtgg                                         29


<210>  637
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  637
gagccgtcgg agtccagc                                                     18


<210>  638
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  638
gcacctgaac tcctgggg                                                     18


<210>  639
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  639
tttaatttcc actttggtgc cg                                                22


<210>  640
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  640
cgcggctagc ttaagcttgg taccgagggc ca                                     32


<210>  641
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  641
cgcggcggcc gcctgatcag cgggtttaaa cttatc                                 36


<210>  642
<211>  2151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMP9

<400>  642
atgagcctct ggcagcccct ggtcctggtg ctcctggtgc tgggctgctg ctttgctgcc       60

cccagacagc gccagtccac ccttgtgctc ttccctggag acctgagaac caatctcacc      120

gacaggcagc tggcagagga atacctgtac cgctatggtt acactcgggt ggcagagatg      180

cgtggagagt cgaaatctct ggggcctgcg ctgctgcttc tccagaagca actgtccctg      240

cccgagaccg gtgagctgga tagcgccacg ctgaaggcca tgcgaacccc acggtgcggg      300

gtcccagacc tgggcagatt ccaaaccttt gagggcgacc tcaagtggca ccaccacaac      360

atcacctatt ggatccaaaa ctactcggaa gacttgccgc gggcggtgat tgacgacgcc      420

tttgcccgcg ccttcgcact gtggagcgcg gtgacgccgc tcaccttcac tcgcgtgtac      480

agccgggacg cagacatcgt catccagttt ggtgtcgcgg agcacggaga cgggtatccc      540

ttcgacggga aggacgggct cctggcacac gcctttcctc ctggccccgg cattcaggga      600

gacgcccatt tcgacgatga cgagttgtgg tccctgggca agggcgtcgt ggttccaact      660

cggtttggaa acgcagatgg cgcggcctgc cacttcccct tcatcttcga gggccgctcc      720

tactctgcct gcaccaccga cggtcgctcc gacggcttgc cctggtgcag taccacggcc      780

aactacgaca ccgacgaccg gtttggcttc tgccccagcg agagactcta cacccaggac      840

ggcaatgctg atgggaaacc ctgccagttt ccattcatct tccaaggcca atcctactcc      900

gcctgcacca cggacggtcg ctccgacggc taccgctggt gcgccaccac cgccaactac      960

gaccgggaca agctcttcgg cttctgcccg acccgagctg actcgacggt gatggggggc     1020

aactcggcgg gggagctgtg cgtcttcccc ttcactttcc tgggtaagga gtactcgacc     1080

tgtaccagcg agggccgcgg agatgggcgc ctctggtgcg ctaccacctc gaactttgac     1140

agcgacaaga agtggggctt ctgcccggac caaggataca gtttgttcct cgtggcggcg     1200

catgagttcg gccacgcgct gggcttagat cattcctcag tgccggaggc gctcatgtac     1260

cctatgtacc gcttcactga ggggcccccc ttgcataagg acgacgtgaa tggcatccgg     1320

cacctctatg gtcctcgccc tgaacctgag ccacggcctc caaccaccac cacaccgcag     1380

cccacggctc ccccgacggt ctgccccacc ggacccccca ctgtccaccc ctcagagcgc     1440

cccacagctg gccccacagg tcccccctca gctggcccca caggtccccc cactgctggc     1500

ccttctacgg ccactactgt gcctttgagt ccggtggacg atgcctgcaa cgtgaacatc     1560

ttcgacgcca tcgcggagat tgggaaccag ctgtatttgt tcaaggatgg gaagtactgg     1620

cgattctctg agggcagggg gagccggccg cagggcccct tccttatcgc cgacaagtgg     1680

cccgcgctgc cccgcaagct ggactcggtc tttgaggagc ggctctccaa gaagcttttc     1740

ttcttctctg ggcgccaggt gtgggtgtac acaggcgcgt cggtgctggg cccgaggcgt     1800

ctggacaagc tgggcctggg agccgacgtg gcccaggtga ccggggccct ccggagtggc     1860

agggggaaga tgctgctgtt cagcgggcgg cgcctctgga ggttcgacgt gaaggcgcag     1920

atggtggatc cccggagcgc cagcgaggtg gaccggatgt tccccggggt gcctttggac     1980

acgcacgacg tcttccagta ccgagagaaa gcctatttct gccaggaccg cttctactgg     2040

cgcgtgagtt cccggagtga gttgaaccag gtggaccaag tgggctacgt gacctatgac     2100

atcctgcagt gccctgagga cgattacaag gatgacgacg ataagtgata a              2151


<210>  643
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP9

<400>  643

Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro 
            20                  25                  30          


Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr 
        35                  40                  45              


Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser 
    50                  55                  60                  


Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu 
65                  70                  75                  80  


Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr 
                85                  90                  95      


Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly 
            100                 105                 110         


Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr 
        115                 120                 125             


Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala 
    130                 135                 140                 


Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr 
145                 150                 155                 160 


Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly 
                165                 170                 175     


Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe 
            180                 185                 190         


Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu 
        195                 200                 205             


Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn 
    210                 215                 220                 


Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser 
225                 230                 235                 240 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys 
                245                 250                 255     


Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro 
            260                 265                 270         


Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys 
        275                 280                 285             


Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr 
    290                 295                 300                 


Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr 
305                 310                 315                 320 


Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr 
                325                 330                 335     


Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr 
            340                 345                 350         


Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp 
        355                 360                 365             


Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys 
    370                 375                 380                 


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
385                 390                 395                 400 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                405                 410                 415     


Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His 
            420                 425                 430         


Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu 
        435                 440                 445             


Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro 
    450                 455                 460                 


Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg 
465                 470                 475                 480 


Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro 
                485                 490                 495     


Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val 
            500                 505                 510         


Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly 
        515                 520                 525             


Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu 
    530                 535                 540                 


Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp 
545                 550                 555                 560 


Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Arg Leu Ser 
                565                 570                 575     


Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly 
            580                 585                 590         


Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala 
        595                 600                 605             


Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met 
    610                 615                 620                 


Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln 
625                 630                 635                 640 


Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly 
                645                 650                 655     


Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr 
            660                 665                 670         


Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu 
        675                 680                 685             


Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys 
    690                 695                 700                 


Pro Glu Asp Asp Tyr Lys Asp Asp Asp Asp Lys 
705                 710                 715 


<210>  644
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMP9 catalytic domain

<400>  644
atgttccaaa cctttgaggg cgacctcaag tggcaccacc acaacatcac ctattggatc       60

caaaactact cggaagactt gccgcgggcg gtgattgacg acgcctttgc ccgcgccttc      120

gcactgtgga gcgcggtgac gccgctcacc ttcactcgcg tgtacagccg ggacgcagac      180

atcgtcatcc agtttggtgt cgcggagcac ggagacgggt atcccttcga cgggaaggac      240

gggctcctgg cacacgcctt tcctcctggc cccggcattc agggagacgc ccatttcgac      300

gatgacgagt tgtggtccct gggcaagggc gtcgtggttc caactcggtt tggaaacgca      360

gatggcgcgg cctgccactt ccccttcatc ttcgagggcc gctcctactc tgcctgcacc      420

accgacggtc gctccgacgg cttgccctgg tgcagtacca cggccaacta cgacaccgac      480

gaccggtttg gcttctgccc cagcgagaga ctctacaccc aggacggcaa tgctgatggg      540

aaaccctgcc agtttccatt catcttccaa ggccaatcct actccgcctg caccacggac      600

ggtcgctccg acggctaccg ctggtgcgcc accaccgcca actacgaccg ggacaagctc      660

ttcggcttct gcccgacccg agctgactcg acggtgatgg ggggcaactc ggcgggggag      720

ctgtgcgtct tccccttcac tttcctgggt aaggagtact cgacctgtac cagcgagggc      780

cgcggagatg ggcgcctctg gtgcgctacc acctcgaact ttgacagcga caagaagtgg      840

ggcttctgcc cggaccaagg atacagtttg ttcctcgtgg cggcgcatga gttcggccac      900

gcgctgggct tagatcattc ctcagtgccg gaggcgctca tgtaccctat gtaccgcttc      960

actgaggggc cccccttgca taaggacgac gtgaatggca tccggcacct ctatggtcct     1020

cgccctgaac ctgattacaa ggatgacgac gataagtgat aa                        1062


<210>  645
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP9

<400>  645

Met Phe Gln Thr Phe Glu Gly Asp Leu Lys Trp His His His Asn Ile 
1               5                   10                  15      


Thr Tyr Trp Ile Gln Asn Tyr Ser Glu Asp Leu Pro Arg Ala Val Ile 
            20                  25                  30          


Asp Asp Ala Phe Ala Arg Ala Phe Ala Leu Trp Ser Ala Val Thr Pro 
        35                  40                  45              


Leu Thr Phe Thr Arg Val Tyr Ser Arg Asp Ala Asp Ile Val Ile Gln 
    50                  55                  60                  


Phe Gly Val Ala Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp 
65                  70                  75                  80  


Gly Leu Leu Ala His Ala Phe Pro Pro Gly Pro Gly Ile Gln Gly Asp 
                85                  90                  95      


Ala His Phe Asp Asp Asp Glu Leu Trp Ser Leu Gly Lys Gly Val Val 
            100                 105                 110         


Val Pro Thr Arg Phe Gly Asn Ala Asp Gly Ala Ala Cys His Phe Pro 
        115                 120                 125             


Phe Ile Phe Glu Gly Arg Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg 
    130                 135                 140                 


Ser Asp Gly Leu Pro Trp Cys Ser Thr Thr Ala Asn Tyr Asp Thr Asp 
145                 150                 155                 160 


Asp Arg Phe Gly Phe Cys Pro Ser Glu Arg Leu Tyr Thr Gln Asp Gly 
                165                 170                 175     


Asn Ala Asp Gly Lys Pro Cys Gln Phe Pro Phe Ile Phe Gln Gly Gln 
            180                 185                 190         


Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Tyr Arg Trp 
        195                 200                 205             


Cys Ala Thr Thr Ala Asn Tyr Asp Arg Asp Lys Leu Phe Gly Phe Cys 
    210                 215                 220                 


Pro Thr Arg Ala Asp Ser Thr Val Met Gly Gly Asn Ser Ala Gly Glu 
225                 230                 235                 240 


Leu Cys Val Phe Pro Phe Thr Phe Leu Gly Lys Glu Tyr Ser Thr Cys 
                245                 250                 255     


Thr Ser Glu Gly Arg Gly Asp Gly Arg Leu Trp Cys Ala Thr Thr Ser 
            260                 265                 270         


Asn Phe Asp Ser Asp Lys Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr 
        275                 280                 285             


Ser Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu 
    290                 295                 300                 


Asp His Ser Ser Val Pro Glu Ala Leu Met Tyr Pro Met Tyr Arg Phe 
305                 310                 315                 320 


Thr Glu Gly Pro Pro Leu His Lys Asp Asp Val Asn Gly Ile Arg His 
                325                 330                 335     


Leu Tyr Gly Pro Arg Pro Glu Pro Asp Tyr Lys Asp Asp Asp Asp Lys 
            340                 345                 350         


<210>  646
<211>  2186
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 Promoter (NFATc1P)

<400>  646
aggcaggagg aagaggaaag gggcgcaggg cgctcgggga gcagagccgg gggcccgcgg       60

tggccgcaga ggccgggccg gggcgcagag gccgggcgag ctggccgcgc tctgggccgc      120

cgcctccgga actccctgcg cctggcgcgc ggccaccgtg gtcccggcaa cggcattaaa      180

cagagggaaa cagacccggg attccgtcac ccgggcgggg ggataaggac ggctttgaga      240

gcagacagga aaagggagct tttctgcatg gggtgaaaaa attatttatt gaaggaggag      300

gaggcggcag cggaggaagg ggaggggcgg gaggaggagg aagagccggc cgcccccgcc      360

ccggccccgg ctcctcagga gccaagggca gcctcgccag gtcggtcccg ggctcgagga      420

ccgcggctgg ggtcgagggg ctcagtctcc cacgtgaccg gctgggcgcg ccccgccaga      480

cccggcctcg ggattccctc ctcccggcga gtctccgccc gccccgtcct ggaggtgggg      540

agaaggaggg cggggcgggg gggacggaaa ctctccccgc caaatcctgg ccccaggcct      600

ggggacactc gcggcgggaa gatttggagg ggaggggagg gggaggggcg tgggggcgcg      660

gcctcgctgg agtccccctg accccccgac ccccgcccac cggcctgggc gtcctcccgc      720

ggcccctcct cccctcccgg cgcccggtgc tctggggcgc gtgccacgcc tggctcggcg      780

ccgtaggggc ccccgcaggt agagacccct ggaaatggcc tcgacgccgc aggagcgagg      840

cggccaccac cccgctaatc cgggcacgtc tctccaggcc gaggcctgcg gtggaaaagc      900

cggggttcca tttgtgctga gtcggggcgg ccgaatggag ccaggcctcg ggacgcggga      960

cggacgggct ctggccgcgc accttcgcgg gctctgcagc gcccgaccgc ctcccccggc     1020

agggaggagg cgcttgtggg gggcacccac ggggcacagt gatccctggg ggtctgcgga     1080

cctcctgggc cccgcagcag acacgagttt agcctttggg tttagtttaa atcacataag     1140

ggtgtcgtgc aatcgattta tggtttctac acaccagaca ctttaacctc caaccccccc     1200

catccaagcc aacaagaaaa tgcggtgccg tgttggcagc tgagctgcgc ccgaagagac     1260

gcagggagac gtaagagagg aaagtgtgag tggccggggg gcctcccccc gtcagaagtc     1320

gcgcagtcgc gcccataaaa cgccccctcc gggcggctag ggcaggtgag cgcgtccccg     1380

ggcctcccca cgccggcccc tgccacagag ccgtctaggt cgagcagata tttacagaat     1440

aaaaatgaca ataactcgac gtcccgggac ggccacgcaa tctgttagta atttagcggg     1500

atgggaattt cctttctagg gcctgccagt gaagcgcttt tccaaatttc cacagcgggg     1560

gaagcctgcg attttacata atgacttcag catgccgggc tttctcgaca cccctccccg     1620

gcccccggcc cccgcccccc gccccttttc cagcagggcc gggctccctc cggacacccg     1680

cgtggactca ggcgtcccgt ctggcccgtt cgcccccgtt tcccccgcca gccccagcgc     1740

ccccctgccc ggcccccgga ttccccgttc ccgcccctac gcccccatcc cctccccgtg     1800

cgcccctccc cgtgcgcccc cctccccgtg cgccccccct ccccgtgcgc ccccctcccc     1860

gtgcgccccc cctccccggg cgcccccctc cccgggcgcc ccccctcccc gtgcgccccc     1920

ccctccccgt gcgccccccc tccccgtgcg cgccccgcct cttgcgcccc tgcccccagg     1980

cgagcggctg ccgcggcgcg gggaggggcg ggcgctcggc gactcgtccc cggggccccg     2040

cgcgggcccg ggcagcaggg gcgtgatgtc acggcaggga gggggcgcgg gagccgccgg     2100

gccggcgggg aggcggggga ggtgttttcc agctttaaaa aggcaggagg cagagcgcgg     2160

ccctgcgtca gagcgagact cagagg                                          2186


<210>  647
<211>  4349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1P-MMP9

<400>  647
aggcaggagg aagaggaaag gggcgcaggg cgctcgggga gcagagccgg gggcccgcgg       60

tggccgcaga ggccgggccg gggcgcagag gccgggcgag ctggccgcgc tctgggccgc      120

cgcctccgga actccctgcg cctggcgcgc ggccaccgtg gtcccggcaa cggcattaaa      180

cagagggaaa cagacccggg attccgtcac ccgggcgggg ggataaggac ggctttgaga      240

gcagacagga aaagggagct tttctgcatg gggtgaaaaa attatttatt gaaggaggag      300

gaggcggcag cggaggaagg ggaggggcgg gaggaggagg aagagccggc cgcccccgcc      360

ccggccccgg ctcctcagga gccaagggca gcctcgccag gtcggtcccg ggctcgagga      420

ccgcggctgg ggtcgagggg ctcagtctcc cacgtgaccg gctgggcgcg ccccgccaga      480

cccggcctcg ggattccctc ctcccggcga gtctccgccc gccccgtcct ggaggtgggg      540

agaaggaggg cggggcgggg gggacggaaa ctctccccgc caaatcctgg ccccaggcct      600

ggggacactc gcggcgggaa gatttggagg ggaggggagg gggaggggcg tgggggcgcg      660

gcctcgctgg agtccccctg accccccgac ccccgcccac cggcctgggc gtcctcccgc      720

ggcccctcct cccctcccgg cgcccggtgc tctggggcgc gtgccacgcc tggctcggcg      780

ccgtaggggc ccccgcaggt agagacccct ggaaatggcc tcgacgccgc aggagcgagg      840

cggccaccac cccgctaatc cgggcacgtc tctccaggcc gaggcctgcg gtggaaaagc      900

cggggttcca tttgtgctga gtcggggcgg ccgaatggag ccaggcctcg ggacgcggga      960

cggacgggct ctggccgcgc accttcgcgg gctctgcagc gcccgaccgc ctcccccggc     1020

agggaggagg cgcttgtggg gggcacccac ggggcacagt gatccctggg ggtctgcgga     1080

cctcctgggc cccgcagcag acacgagttt agcctttggg tttagtttaa atcacataag     1140

ggtgtcgtgc aatcgattta tggtttctac acaccagaca ctttaacctc caaccccccc     1200

catccaagcc aacaagaaaa tgcggtgccg tgttggcagc tgagctgcgc ccgaagagac     1260

gcagggagac gtaagagagg aaagtgtgag tggccggggg gcctcccccc gtcagaagtc     1320

gcgcagtcgc gcccataaaa cgccccctcc gggcggctag ggcaggtgag cgcgtccccg     1380

ggcctcccca cgccggcccc tgccacagag ccgtctaggt cgagcagata tttacagaat     1440

aaaaatgaca ataactcgac gtcccgggac ggccacgcaa tctgttagta atttagcggg     1500

atgggaattt cctttctagg gcctgccagt gaagcgcttt tccaaatttc cacagcgggg     1560

gaagcctgcg attttacata atgacttcag catgccgggc tttctcgaca cccctccccg     1620

gcccccggcc cccgcccccc gccccttttc cagcagggcc gggctccctc cggacacccg     1680

cgtggactca ggcgtcccgt ctggcccgtt cgcccccgtt tcccccgcca gccccagcgc     1740

ccccctgccc ggcccccgga ttccccgttc ccgcccctac gcccccatcc cctccccgtg     1800

cgcccctccc cgtgcgcccc cctccccgtg cgccccccct ccccgtgcgc ccccctcccc     1860

gtgcgccccc cctccccggg cgcccccctc cccgggcgcc ccccctcccc gtgcgccccc     1920

ccctccccgt gcgccccccc tccccgtgcg cgccccgcct cttgcgcccc tgcccccagg     1980

cgagcggctg ccgcggcgcg gggaggggcg ggcgctcggc gactcgtccc cggggccccg     2040

cgcgggcccg ggcagcaggg gcgtgatgtc acggcaggga gggggcgcgg gagccgccgg     2100

gccggcgggg aggcggggga ggtgttttcc agctttaaaa aggcaggagg cagagcgcgg     2160

ccctgcgtca gagcgagact cagaggtcta gagccaccat gagcctctgg cagcccctgg     2220

tcctggtgct cctggtgctg ggctgctgct ttgctgcccc cagacagcgc cagtccaccc     2280

ttgtgctctt ccctggagac ctgagaacca atctcaccga caggcagctg gcagaggaat     2340

acctgtaccg ctatggttac actcgggtgg cagagatgcg tggagagtcg aaatctctgg     2400

ggcctgcgct gctgcttctc cagaagcaac tgtccctgcc cgagaccggt gagctggata     2460

gcgccacgct gaaggccatg cgaaccccac ggtgcggggt cccagacctg ggcagattcc     2520

aaacctttga gggcgacctc aagtggcacc accacaacat cacctattgg atccaaaact     2580

actcggaaga cttgccgcgg gcggtgattg acgacgcctt tgcccgcgcc ttcgcactgt     2640

ggagcgcggt gacgccgctc accttcactc gcgtgtacag ccgggacgca gacatcgtca     2700

tccagtttgg tgtcgcggag cacggagacg ggtatccctt cgacgggaag gacgggctcc     2760

tggcacacgc ctttcctcct ggccccggca ttcagggaga cgcccatttc gacgatgacg     2820

agttgtggtc cctgggcaag ggcgtcgtgg ttccaactcg gtttggaaac gcagatggcg     2880

cggcctgcca cttccccttc atcttcgagg gccgctccta ctctgcctgc accaccgacg     2940

gtcgctccga cggcttgccc tggtgcagta ccacggccaa ctacgacacc gacgaccggt     3000

ttggcttctg ccccagcgag agactctaca cccaggacgg caatgctgat gggaaaccct     3060

gccagtttcc attcatcttc caaggccaat cctactccgc ctgcaccacg gacggtcgct     3120

ccgacggcta ccgctggtgc gccaccaccg ccaactacga ccgggacaag ctcttcggct     3180

tctgcccgac ccgagctgac tcgacggtga tggggggcaa ctcggcgggg gagctgtgcg     3240

tcttcccctt cactttcctg ggtaaggagt actcgacctg taccagcgag ggccgcggag     3300

atgggcgcct ctggtgcgct accacctcga actttgacag cgacaagaag tggggcttct     3360

gcccggacca aggatacagt ttgttcctcg tggcggcgca tgagttcggc cacgcgctgg     3420

gcttagatca ttcctcagtg ccggaggcgc tcatgtaccc tatgtaccgc ttcactgagg     3480

ggcccccctt gcataaggac gacgtgaatg gcatccggca cctctatggt cctcgccctg     3540

aacctgagcc acggcctcca accaccacca caccgcagcc cacggctccc ccgacggtct     3600

gccccaccgg accccccact gtccacccct cagagcgccc cacagctggc cccacaggtc     3660

ccccctcagc tggccccaca ggtcccccca ctgctggccc ttctacggcc actactgtgc     3720

ctttgagtcc ggtggacgat gcctgcaacg tgaacatctt cgacgccatc gcggagattg     3780

ggaaccagct gtatttgttc aaggatggga agtactggcg attctctgag ggcaggggga     3840

gccggccgca gggccccttc cttatcgccg acaagtggcc cgcgctgccc cgcaagctgg     3900

actcggtctt tgaggagcgg ctctccaaga agcttttctt cttctctggg cgccaggtgt     3960

gggtgtacac aggcgcgtcg gtgctgggcc cgaggcgtct ggacaagctg ggcctgggag     4020

ccgacgtggc ccaggtgacc ggggccctcc ggagtggcag ggggaagatg ctgctgttca     4080

gcgggcggcg cctctggagg ttcgacgtga aggcgcagat ggtggatccc cggagcgcca     4140

gcgaggtgga ccggatgttc cccggggtgc ctttggacac gcacgacgtc ttccagtacc     4200

gagagaaagc ctatttctgc caggaccgct tctactggcg cgtgagttcc cggagtgagt     4260

tgaaccaggt ggaccaagtg ggctacgtga cctatgacat cctgcagtgc cctgaggacg     4320

attacaagga tgacgacgat aagtgataa                                       4349


<210>  648
<211>  3260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1P-MMP9cat

<400>  648
aggcaggagg aagaggaaag gggcgcaggg cgctcgggga gcagagccgg gggcccgcgg       60

tggccgcaga ggccgggccg gggcgcagag gccgggcgag ctggccgcgc tctgggccgc      120

cgcctccgga actccctgcg cctggcgcgc ggccaccgtg gtcccggcaa cggcattaaa      180

cagagggaaa cagacccggg attccgtcac ccgggcgggg ggataaggac ggctttgaga      240

gcagacagga aaagggagct tttctgcatg gggtgaaaaa attatttatt gaaggaggag      300

gaggcggcag cggaggaagg ggaggggcgg gaggaggagg aagagccggc cgcccccgcc      360

ccggccccgg ctcctcagga gccaagggca gcctcgccag gtcggtcccg ggctcgagga      420

ccgcggctgg ggtcgagggg ctcagtctcc cacgtgaccg gctgggcgcg ccccgccaga      480

cccggcctcg ggattccctc ctcccggcga gtctccgccc gccccgtcct ggaggtgggg      540

agaaggaggg cggggcgggg gggacggaaa ctctccccgc caaatcctgg ccccaggcct      600

ggggacactc gcggcgggaa gatttggagg ggaggggagg gggaggggcg tgggggcgcg      660

gcctcgctgg agtccccctg accccccgac ccccgcccac cggcctgggc gtcctcccgc      720

ggcccctcct cccctcccgg cgcccggtgc tctggggcgc gtgccacgcc tggctcggcg      780

ccgtaggggc ccccgcaggt agagacccct ggaaatggcc tcgacgccgc aggagcgagg      840

cggccaccac cccgctaatc cgggcacgtc tctccaggcc gaggcctgcg gtggaaaagc      900

cggggttcca tttgtgctga gtcggggcgg ccgaatggag ccaggcctcg ggacgcggga      960

cggacgggct ctggccgcgc accttcgcgg gctctgcagc gcccgaccgc ctcccccggc     1020

agggaggagg cgcttgtggg gggcacccac ggggcacagt gatccctggg ggtctgcgga     1080

cctcctgggc cccgcagcag acacgagttt agcctttggg tttagtttaa atcacataag     1140

ggtgtcgtgc aatcgattta tggtttctac acaccagaca ctttaacctc caaccccccc     1200

catccaagcc aacaagaaaa tgcggtgccg tgttggcagc tgagctgcgc ccgaagagac     1260

gcagggagac gtaagagagg aaagtgtgag tggccggggg gcctcccccc gtcagaagtc     1320

gcgcagtcgc gcccataaaa cgccccctcc gggcggctag ggcaggtgag cgcgtccccg     1380

ggcctcccca cgccggcccc tgccacagag ccgtctaggt cgagcagata tttacagaat     1440

aaaaatgaca ataactcgac gtcccgggac ggccacgcaa tctgttagta atttagcggg     1500

atgggaattt cctttctagg gcctgccagt gaagcgcttt tccaaatttc cacagcgggg     1560

gaagcctgcg attttacata atgacttcag catgccgggc tttctcgaca cccctccccg     1620

gcccccggcc cccgcccccc gccccttttc cagcagggcc gggctccctc cggacacccg     1680

cgtggactca ggcgtcccgt ctggcccgtt cgcccccgtt tcccccgcca gccccagcgc     1740

ccccctgccc ggcccccgga ttccccgttc ccgcccctac gcccccatcc cctccccgtg     1800

cgcccctccc cgtgcgcccc cctccccgtg cgccccccct ccccgtgcgc ccccctcccc     1860

gtgcgccccc cctccccggg cgcccccctc cccgggcgcc ccccctcccc gtgcgccccc     1920

ccctccccgt gcgccccccc tccccgtgcg cgccccgcct cttgcgcccc tgcccccagg     1980

cgagcggctg ccgcggcgcg gggaggggcg ggcgctcggc gactcgtccc cggggccccg     2040

cgcgggcccg ggcagcaggg gcgtgatgtc acggcaggga gggggcgcgg gagccgccgg     2100

gccggcgggg aggcggggga ggtgttttcc agctttaaaa aggcaggagg cagagcgcgg     2160

ccctgcgtca gagcgagact cagaggtcta gagccaccat gttccaaacc tttgagggcg     2220

acctcaagtg gcaccaccac aacatcacct attggatcca aaactactcg gaagacttgc     2280

cgcgggcggt gattgacgac gcctttgccc gcgccttcgc actgtggagc gcggtgacgc     2340

cgctcacctt cactcgcgtg tacagccggg acgcagacat cgtcatccag tttggtgtcg     2400

cggagcacgg agacgggtat cccttcgacg ggaaggacgg gctcctggca cacgcctttc     2460

ctcctggccc cggcattcag ggagacgccc atttcgacga tgacgagttg tggtccctgg     2520

gcaagggcgt cgtggttcca actcggtttg gaaacgcaga tggcgcggcc tgccacttcc     2580

ccttcatctt cgagggccgc tcctactctg cctgcaccac cgacggtcgc tccgacggct     2640

tgccctggtg cagtaccacg gccaactacg acaccgacga ccggtttggc ttctgcccca     2700

gcgagagact ctacacccag gacggcaatg ctgatgggaa accctgccag tttccattca     2760

tcttccaagg ccaatcctac tccgcctgca ccacggacgg tcgctccgac ggctaccgct     2820

ggtgcgccac caccgccaac tacgaccggg acaagctctt cggcttctgc ccgacccgag     2880

ctgactcgac ggtgatgggg ggcaactcgg cgggggagct gtgcgtcttc cccttcactt     2940

tcctgggtaa ggagtactcg acctgtacca gcgagggccg cggagatggg cgcctctggt     3000

gcgctaccac ctcgaacttt gacagcgaca agaagtgggg cttctgcccg gaccaaggat     3060

acagtttgtt cctcgtggcg gcgcatgagt tcggccacgc gctgggctta gatcattcct     3120

cagtgccgga ggcgctcatg taccctatgt accgcttcac tgaggggccc cccttgcata     3180

aggacgacgt gaatggcatc cggcacctct atggtcctcg ccctgaacct gattacaagg     3240

atgacgacga taagtgataa                                                 3260


<210>  649
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT response element

<400>  649
ggaggaaaaa ctgtttcata cagaaggcgt                                        30


<210>  650
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT response element repeats

<400>  650
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt       60

ggaggaaaaa ctgtttcata cagaaggcgt                                        90


<210>  651
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV minimal promoter

<400>  651
aggtaggcgt gtacggtggg aggtctatat aagcagagct ggtttagtga accgtcagat       60

c                                                                       61


<210>  652
<211>  2326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATREmCMV-MMP9

<400>  652
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt       60

ggaggaaaaa ctgtttcata cagaaggcgt agatctagac tcaggtaggc gtgtacggtg      120

ggaggtctat ataagcagag ctggtttagt gaaccgtcag atctctagag ccaccatgag      180

cctctggcag cccctggtcc tggtgctcct ggtgctgggc tgctgctttg ctgcccccag      240

acagcgccag tccacccttg tgctcttccc tggagacctg agaaccaatc tcaccgacag      300

gcagctggca gaggaatacc tgtaccgcta tggttacact cgggtggcag agatgcgtgg      360

agagtcgaaa tctctggggc ctgcgctgct gcttctccag aagcaactgt ccctgcccga      420

gaccggtgag ctggatagcg ccacgctgaa ggccatgcga accccacggt gcggggtccc      480

agacctgggc agattccaaa cctttgaggg cgacctcaag tggcaccacc acaacatcac      540

ctattggatc caaaactact cggaagactt gccgcgggcg gtgattgacg acgcctttgc      600

ccgcgccttc gcactgtgga gcgcggtgac gccgctcacc ttcactcgcg tgtacagccg      660

ggacgcagac atcgtcatcc agtttggtgt cgcggagcac ggagacgggt atcccttcga      720

cgggaaggac gggctcctgg cacacgcctt tcctcctggc cccggcattc agggagacgc      780

ccatttcgac gatgacgagt tgtggtccct gggcaagggc gtcgtggttc caactcggtt      840

tggaaacgca gatggcgcgg cctgccactt ccccttcatc ttcgagggcc gctcctactc      900

tgcctgcacc accgacggtc gctccgacgg cttgccctgg tgcagtacca cggccaacta      960

cgacaccgac gaccggtttg gcttctgccc cagcgagaga ctctacaccc aggacggcaa     1020

tgctgatggg aaaccctgcc agtttccatt catcttccaa ggccaatcct actccgcctg     1080

caccacggac ggtcgctccg acggctaccg ctggtgcgcc accaccgcca actacgaccg     1140

ggacaagctc ttcggcttct gcccgacccg agctgactcg acggtgatgg ggggcaactc     1200

ggcgggggag ctgtgcgtct tccccttcac tttcctgggt aaggagtact cgacctgtac     1260

cagcgagggc cgcggagatg ggcgcctctg gtgcgctacc acctcgaact ttgacagcga     1320

caagaagtgg ggcttctgcc cggaccaagg atacagtttg ttcctcgtgg cggcgcatga     1380

gttcggccac gcgctgggct tagatcattc ctcagtgccg gaggcgctca tgtaccctat     1440

gtaccgcttc actgaggggc cccccttgca taaggacgac gtgaatggca tccggcacct     1500

ctatggtcct cgccctgaac ctgagccacg gcctccaacc accaccacac cgcagcccac     1560

ggctcccccg acggtctgcc ccaccggacc ccccactgtc cacccctcag agcgccccac     1620

agctggcccc acaggtcccc cctcagctgg ccccacaggt ccccccactg ctggcccttc     1680

tacggccact actgtgcctt tgagtccggt ggacgatgcc tgcaacgtga acatcttcga     1740

cgccatcgcg gagattggga accagctgta tttgttcaag gatgggaagt actggcgatt     1800

ctctgagggc agggggagcc ggccgcaggg ccccttcctt atcgccgaca agtggcccgc     1860

gctgccccgc aagctggact cggtctttga ggagcggctc tccaagaagc ttttcttctt     1920

ctctgggcgc caggtgtggg tgtacacagg cgcgtcggtg ctgggcccga ggcgtctgga     1980

caagctgggc ctgggagccg acgtggccca ggtgaccggg gccctccgga gtggcagggg     2040

gaagatgctg ctgttcagcg ggcggcgcct ctggaggttc gacgtgaagg cgcagatggt     2100

ggatccccgg agcgccagcg aggtggaccg gatgttcccc ggggtgcctt tggacacgca     2160

cgacgtcttc cagtaccgag agaaagccta tttctgccag gaccgcttct actggcgcgt     2220

gagttcccgg agtgagttga accaggtgga ccaagtgggc tacgtgacct atgacatcct     2280

gcagtgccct gaggacgatt acaaggatga cgacgataag tgataa                    2326


<210>  653
<211>  1237
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATREmCMV-MMP9cat

<400>  653
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt       60

ggaggaaaaa ctgtttcata cagaaggcgt agatctagac tcaggtaggc gtgtacggtg      120

ggaggtctat ataagcagag ctggtttagt gaaccgtcag atctctagag ccaccatgtt      180

ccaaaccttt gagggcgacc tcaagtggca ccaccacaac atcacctatt ggatccaaaa      240

ctactcggaa gacttgccgc gggcggtgat tgacgacgcc tttgcccgcg ccttcgcact      300

gtggagcgcg gtgacgccgc tcaccttcac tcgcgtgtac agccgggacg cagacatcgt      360

catccagttt ggtgtcgcgg agcacggaga cgggtatccc ttcgacggga aggacgggct      420

cctggcacac gcctttcctc ctggccccgg cattcaggga gacgcccatt tcgacgatga      480

cgagttgtgg tccctgggca agggcgtcgt ggttccaact cggtttggaa acgcagatgg      540

cgcggcctgc cacttcccct tcatcttcga gggccgctcc tactctgcct gcaccaccga      600

cggtcgctcc gacggcttgc cctggtgcag taccacggcc aactacgaca ccgacgaccg      660

gtttggcttc tgccccagcg agagactcta cacccaggac ggcaatgctg atgggaaacc      720

ctgccagttt ccattcatct tccaaggcca atcctactcc gcctgcacca cggacggtcg      780

ctccgacggc taccgctggt gcgccaccac cgccaactac gaccgggaca agctcttcgg      840

cttctgcccg acccgagctg actcgacggt gatggggggc aactcggcgg gggagctgtg      900

cgtcttcccc ttcactttcc tgggtaagga gtactcgacc tgtaccagcg agggccgcgg      960

agatgggcgc ctctggtgcg ctaccacctc gaactttgac agcgacaaga agtggggctt     1020

ctgcccggac caaggataca gtttgttcct cgtggcggcg catgagttcg gccacgcgct     1080

gggcttagat cattcctcag tgccggaggc gctcatgtac cctatgtacc gcttcactga     1140

ggggcccccc ttgcataagg acgacgtgaa tggcatccgg cacctctatg gtcctcgccc     1200

tgaacctgat tacaaggatg acgacgataa gtgataa                              1237


<210>  654
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 scFv

<400>  654
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaact                                          747


<210>  655
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2 scFv

<400>  655

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 


<210>  656
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  656
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  657
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  657

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  658
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB domain

<400>  658
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  659
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB domain

<400>  659

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  660
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3zeta domain

<400>  660
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  661
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta domain

<400>  661

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  662
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc linker

<400>  662
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaa                                696


<210>  663
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc linker

<400>  663

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  664
<211>  1983
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 CAR FC linker

<400>  664
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaactgag cccaaatctt gtgacaaaac tcacacatgc      780

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      900

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1080

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1140

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1440

aaaatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1500

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1560

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1620

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1680

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1740

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1800

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1860

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1920

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctga     1980

taa                                                                   1983


<210>  665
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2 CAR FC linker

<400>  665

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                485                 490                 495     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            500                 505                 510         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        515                 520                 525             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    530                 535                 540                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
545                 550                 555                 560 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                565                 570                 575     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            580                 585                 590         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        595                 600                 605             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    610                 615                 620                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
625                 630                 635                 640 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                645                 650                 655     


Pro Pro Arg 
            


<210>  666
<211>  870
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgD/Fc linker

<400>  666
gagtctccaa aggcacaggc ctcctcagtg cccactgcac aaccccaagc agagggcagc       60

ctcgccaagg caaccacagc cccagccacc acccgtaaca caggaagagg cggcgaagag      120

aagaaaaagg agaaggagaa agaggaacaa gaagagagag agacaaagac accagagccc      180

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      240

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      300

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      360

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      420

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      480

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      540

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      600

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      660

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      720

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      780

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      840

cagaagagcc tctccctgtc tccgggtaaa                                       870


<210>  667
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgD/Fc linker

<400>  667

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Pro Lys Ser Cys Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    130                 135                 140                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  668
<211>  2157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 CAR IgD/FC linker

<400>  668
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaactgag tctccaaagg cacaggcctc ctcagtgccc      780

actgcacaac cccaagcaga gggcagcctc gccaaggcaa ccacagcccc agccaccacc      840

cgtaacacag gaagaggcgg cgaagagaag aaaaaggaga aggagaaaga ggaacaagaa      900

gagagagaga caaagacacc agagcccaaa tcttgtgaca aaactcacac atgcccaccg      960

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag     1020

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac     1080

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1140

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1200

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1260

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1320

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1380

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1440

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1500

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1560

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaaatc     1620

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1680

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1740

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1800

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     1860

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1920

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1980

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     2040

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     2100

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctgataa        2157


<210>  669
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2 CAR IgD/FC linker

<400>  669

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Glu Ser Pro Lys Ala Gln Ala 
                245                 250                 255     


Ser Ser Val Pro Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys 
            260                 265                 270         


Ala Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu 
        275                 280                 285             


Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr 
    290                 295                 300                 


Lys Thr Pro Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
305                 310                 315                 320 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                325                 330                 335     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            340                 345                 350         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        355                 360                 365             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    370                 375                 380                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
385                 390                 395                 400 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                405                 410                 415     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            420                 425                 430         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        435                 440                 445             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    450                 455                 460                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
465                 470                 475                 480 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                485                 490                 495     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            500                 505                 510         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        515                 520                 525             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Tyr Ile Trp Ala 
    530                 535                 540                 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
545                 550                 555                 560 


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                565                 570                 575     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            580                 585                 590         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        595                 600                 605             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
    610                 615                 620                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
625                 630                 635                 640 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                645                 650                 655     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            660                 665                 670         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        675                 680                 685             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    690                 695                 700                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
705                 710                 715         


<210>  670
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc hingeless Y407R linker

<400>  670
gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc       60

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      120

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      180

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      240

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc      300

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc      360

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa      420

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac      480

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcag gagcaagctc      540

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag      600

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a               651


<210>  671
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc hingeless Y407R linker

<400>  671

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Arg Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  672
<211>  1938
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 CAR FCHingeless/Y407R linker

<400>  672
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaactgca cctgaactcc tggggggacc gtcagtcttc      780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      840

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      900

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      960

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1020

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1080

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac     1140

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1200

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1260

ggctccttct tcctcaggag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1320

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1380

tccctgtctc cgggtaaaat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1440

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1500

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1560

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1620

gacgcccccg cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga     1680

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1740

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1800

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1860

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1920

ctgccccctc gctgataa                                                   1938


<210>  673
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2 CAR FCHingeless/Y407R linker

<400>  673

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Arg Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
465                 470                 475                 480 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                485                 490                 495     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            500                 505                 510         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        515                 520                 525             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    530                 535                 540                 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
545                 550                 555                 560 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                565                 570                 575     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            580                 585                 590         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        595                 600                 605             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    610                 615                 620                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
625                 630                 635                 640 


Leu Pro Pro Arg 
                


<210>  674
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgD/FCHingeless/Y407R linker

<400>  674
gagtctccaa aggcacaggc ctcctcagtg cccactgcac aaccccaagc agagggcagc       60

ctcgccaagg caaccacagc cccagccacc acccgtaaca caggaagagg cggcgaagag      120

aagaaaaagg agaaggagaa agaggaacaa gaagagagag agacaaagac accagcacct      180

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      240

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      300

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      360

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      420

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      480

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      540

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      600

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      660

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tcaggagcaa gctcaccgtg      720

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      780

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                      825


<210>  675
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgD/FCHingeless/Y407R linker

<400>  675

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Ala Pro Glu Leu Leu Gly 
    50                  55                  60                  


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
65                  70                  75                  80  


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                85                  90                  95      


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            100                 105                 110         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        115                 120                 125             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    130                 135                 140                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
145                 150                 155                 160 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                165                 170                 175     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            180                 185                 190         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        195                 200                 205             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    210                 215                 220                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Arg Ser Lys Leu Thr Val 
225                 230                 235                 240 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                245                 250                 255     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            260                 265                 270         


Pro Gly Lys 
        275 


<210>  676
<211>  2045
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 CAR IgD/FCHingeless/Y407R linker

<400>  676
cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag gctccaggga       60

aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac taccccgact      120

cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg tatctgcaaa      180

tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt gggggggata      240

attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc tcctccggcg      300

gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg ctgacccagt      360

ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc agagccagta      420

agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa ccaggacaac      480

ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca gccaggttca      540

gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa gctaatgata      600

ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc ggagggacca      660

aggtggagat caaacgaact gagtctccaa aggcacaggc ctcctcagtg cccactgcac      720

aaccccaagc agagggcagc ctcgccaagg caaccacagc cccagccacc acccgtaaca      780

caggaagagg cggcgaagag aagaaaaagg agaaggagaa agaggaacaa gaagagagag      840

agacaaagac accagcacct gaactcctgg ggggaccgtc agtcttcctc ttccccccaa      900

aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg gtggtggacg      960

tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg gaggtgcata     1020

atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc     1080

tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag gtctccaaca     1140

aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag ccccgagaac     1200

cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag gtcagcctga     1260

cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag agcaatgggc     1320

agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc tccttcttcc     1380

tcaggagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc ttctcatgct     1440

ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc ctgtctccgg     1500

gtaaaatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc ctgtcactgg     1560

ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc aaacaaccat     1620

ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga tttccagaag     1680

aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac gcccccgcgt     1740

acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga gaggagtacg     1800

atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg agaaggaaga     1860

accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag gcctacagtg     1920

agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt taccagggtc     1980

tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg ccccctcgct     2040

gataa                                                                 2045


<210>  677
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2 CAR IgD/FCHingeless/Y407R linker

<400>  677

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Glu Ser Pro Lys Ala Gln Ala 
                245                 250                 255     


Ser Ser Val Pro Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys 
            260                 265                 270         


Ala Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu 
        275                 280                 285             


Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr 
    290                 295                 300                 


Lys Thr Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
305                 310                 315                 320 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                325                 330                 335     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            340                 345                 350         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        355                 360                 365             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    370                 375                 380                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
385                 390                 395                 400 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                405                 410                 415     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            420                 425                 430         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        435                 440                 445             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    450                 455                 460                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
465                 470                 475                 480 


Phe Phe Leu Arg Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                485                 490                 495     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            500                 505                 510         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Tyr Ile Trp 
        515                 520                 525             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    530                 535                 540                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
545                 550                 555                 560 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                565                 570                 575     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            580                 585                 590         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        595                 600                 605             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    610                 615                 620                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
625                 630                 635                 640 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                645                 650                 655     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            660                 665                 670         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        675                 680                 685             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    690                 695                 700         


<210>  678
<211>  174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgD linker

<400>  678
gagtctccaa aggcacaggc ctcctcagtg cccactgcac aaccccaagc agagggcagc       60

ctcgccaagg caaccacagc cccagccacc acccgtaaca caggaagagg cggcgaagag      120

aagaaaaagg agaaggagaa agaggaacaa gaagagagag agacaaagac acca            174


<210>  679
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgD linker

<400>  679

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro 
    50                  55              


<210>  680
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 CAR IgD linker

<400>  680
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaactgag tctccaaagg cacaggcctc ctcagtgccc      780

actgcacaac cccaagcaga gggcagcctc gccaaggcaa ccacagcccc agccaccacc      840

cgtaacacag gaagaggcgg cgaagagaag aaaaaggaga aggagaaaga ggaacaagaa      900

gagagagaga caaagacacc aatctacatc tgggcgccct tggccgggac ttgtggggtc      960

cttctcctgt cactggttat caccctttac tgcaaacggg gcagaaagaa actcctgtat     1020

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1080

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     1140

gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga     1200

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1260

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1320

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1380

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1440

gccctgcccc ctcgctgata a                                               1461


<210>  681
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2 CAR IgD linker

<400>  681

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Glu Ser Pro Lys Ala Gln Ala 
                245                 250                 255     


Ser Ser Val Pro Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys 
            260                 265                 270         


Ala Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu 
        275                 280                 285             


Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr 
    290                 295                 300                 


Lys Thr Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  682
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  X4 linker

<400>  682
gacaagacgc acaccaagcc acctaaacca gctccagaac tgctcggagg tcctggcacc       60

ggaaccggag gacctaccat caaaccacct aagccaccta agcctgctcc taacctgctc      120

ggaggacct                                                              129


<210>  683
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  X4 linker

<400>  683

Asp Lys Thr His Thr Lys Pro Pro Lys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Gly Thr Gly Thr Gly Gly Pro Thr Ile Lys Pro Pro Lys Pro 
            20                  25                  30          


Pro Lys Pro Ala Pro Asn Leu Leu Gly Gly Pro 
        35                  40              


<210>  684
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 CAR X4 linker

<400>  684
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaactgac aagacgcaca ccaagccacc taaaccagct      780

ccagaactgc tcggaggtcc tggcaccgga accggaggac ctaccatcaa accacctaag      840

ccacctaagc ctgctcctaa cctgctcgga ggacctatct acatctgggc gcccttggcc      900

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga      960

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1020

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1080

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1140

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1200

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1260

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1320

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1380

gcccttcaca tgcaggccct gccccctcgc tgataa                               1416


<210>  685
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2 CAR X4 linker

<400>  685

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Asp Lys Thr His Thr Lys Pro 
                245                 250                 255     


Pro Lys Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Thr Gly 
            260                 265                 270         


Gly Pro Thr Ile Lys Pro Pro Lys Pro Pro Lys Pro Ala Pro Asn Leu 
        275                 280                 285             


Leu Gly Gly Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
    290                 295                 300                 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
305                 310                 315                 320 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                325                 330                 335     


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            340                 345                 350         


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        355                 360                 365             


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    370                 375                 380                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
385                 390                 395                 400 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                405                 410                 415     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            420                 425                 430         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        435                 440                 445             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    450                 455                 460                 


Gln Ala Leu Pro Pro Arg 
465                 470 


<210>  686
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OKT3 scFv

<400>  686
caggtgcagc tggtgcagag cggaggcgga gtggtgcagc ctggaagaag cctgcgcctg       60

agctgcaaag cgagcggcta tacctttacc cgctatacca tgcattgggt gcgccaggcg      120

ccgggcaaag gcctggaatg gattggctat attaacccga gccgcggcta taccaactat      180

aaccagaaag tgaaagatcg ctttaccatt agcaccgata aaagcaaaag caccgcgttt      240

ctgcagatgg atagcctgcg cccggaagat accgcggtgt attattgcgc gcgctattat      300

gatgatcatt attgcctgga ttattggggc cagggcacca ccctgaccgt gagcagcggc      360

ggtggcggat ccggcggtgg cggatccggc ggtggcggat ccgatattca gatgacccag      420

agcccgagca gcctgagcgc gagcgtgggc gatcgcgtga ccattacctg cagcgcgagc      480

agcagcgtga gctatatgaa ctggtatcag cagaccccgg gcaaagcgcc gaaacgctgg      540

atttatgata ccagcaaact ggcgagcggc gtgccgagcc gctttagcgg cagcggcagc      600

ggcaccgatt atacctttac cattagcagc ctgcagccgg aagatattgc gacctattat      660

tgccagcagt ggagcagcaa cccgtttacc tttggccagg gcaccaaact gcagattacc      720

cgctgataa                                                              729


<210>  687
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 scFv

<400>  687

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
225                 230                 235                 240 


Arg 
    


<210>  688
<211>  2187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2-FC-OKT3

<400>  688
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaactgag cccaaatctt gtgacaaaac tcacacatgc      780

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      900

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1080

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1140

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1440

aaaggcggtg gcggatccca ggtgcagctg gtgcagagcg gaggcggagt ggtgcagcct     1500

ggaagaagcc tgcgcctgag ctgcaaagcg agcggctata cctttacccg ctataccatg     1560

cattgggtgc gccaggcgcc gggcaaaggc ctggaatgga ttggctatat taacccgagc     1620

cgcggctata ccaactataa ccagaaagtg aaagatcgct ttaccattag caccgataaa     1680

agcaaaagca ccgcgtttct gcagatggat agcctgcgcc cggaagatac cgcggtgtat     1740

tattgcgcgc gctattatga tgatcattat tgcctggatt attggggcca gggcaccacc     1800

ctgaccgtga gcagcggcgg tggcggatcc ggcggtggcg gatccggcgg tggcggatcc     1860

gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc     1920

attacctgca gcgcgagcag cagcgtgagc tatatgaact ggtatcagca gaccccgggc     1980

aaagcgccga aacgctggat ttatgatacc agcaaactgg cgagcggcgt gccgagccgc     2040

tttagcggca gcggcagcgg caccgattat acctttacca ttagcagcct gcagccggaa     2100

gatattgcga cctattattg ccagcagtgg agcagcaacc cgtttacctt tggccagggc     2160

accaaactgc agattacccg ctgataa                                         2187


<210>  689
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2-FC-OKT3

<400>  689

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
                485                 490                 495     


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly 
            500                 505                 510         


Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly 
        515                 520                 525             


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr 
    530                 535                 540                 


Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys 
545                 550                 555                 560 


Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp 
                565                 570                 575     


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu 
            580                 585                 590         


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    610                 615                 620                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
625                 630                 635                 640 


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
                645                 650                 655     


Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
            660                 665                 670         


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        675                 680                 685             


Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
    690                 695                 700                 


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly 
705                 710                 715                 720 


Thr Lys Leu Gln Ile Thr Arg 
                725         


<210>  690
<211>  2361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2-IgD/FC-OKT3

<400>  690
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaactgag tctccaaagg cacaggcctc ctcagtgccc      780

actgcacaac cccaagcaga gggcagcctc gccaaggcaa ccacagcccc agccaccacc      840

cgtaacacag gaagaggcgg cgaagagaag aaaaaggaga aggagaaaga ggaacaagaa      900

gagagagaga caaagacacc agagcccaaa tcttgtgaca aaactcacac atgcccaccg      960

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag     1020

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac     1080

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1140

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1200

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1260

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1320

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1380

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1440

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1500

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1560

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaaggc     1620

ggtggcggat cccaggtgca gctggtgcag agcggaggcg gagtggtgca gcctggaaga     1680

agcctgcgcc tgagctgcaa agcgagcggc tataccttta cccgctatac catgcattgg     1740

gtgcgccagg cgccgggcaa aggcctggaa tggattggct atattaaccc gagccgcggc     1800

tataccaact ataaccagaa agtgaaagat cgctttacca ttagcaccga taaaagcaaa     1860

agcaccgcgt ttctgcagat ggatagcctg cgcccggaag ataccgcggt gtattattgc     1920

gcgcgctatt atgatgatca ttattgcctg gattattggg gccagggcac caccctgacc     1980

gtgagcagcg gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atccgatatt     2040

cagatgaccc agagcccgag cagcctgagc gcgagcgtgg gcgatcgcgt gaccattacc     2100

tgcagcgcga gcagcagcgt gagctatatg aactggtatc agcagacccc gggcaaagcg     2160

ccgaaacgct ggatttatga taccagcaaa ctggcgagcg gcgtgccgag ccgctttagc     2220

ggcagcggca gcggcaccga ttataccttt accattagca gcctgcagcc ggaagatatt     2280

gcgacctatt attgccagca gtggagcagc aacccgttta cctttggcca gggcaccaaa     2340

ctgcagatta cccgctgata a                                               2361


<210>  691
<211>  785
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2-IgD/FC-OKT3

<400>  691

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Glu Ser Pro Lys Ala Gln Ala 
                245                 250                 255     


Ser Ser Val Pro Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys 
            260                 265                 270         


Ala Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu 
        275                 280                 285             


Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr 
    290                 295                 300                 


Lys Thr Pro Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
305                 310                 315                 320 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                325                 330                 335     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            340                 345                 350         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        355                 360                 365             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    370                 375                 380                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
385                 390                 395                 400 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                405                 410                 415     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            420                 425                 430         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        435                 440                 445             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    450                 455                 460                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
465                 470                 475                 480 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                485                 490                 495     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            500                 505                 510         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        515                 520                 525             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
545                 550                 555                 560 


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
                565                 570                 575     


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
            580                 585                 590         


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val 
        595                 600                 605             


Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys Ser Lys Ser Thr Ala Phe 
    610                 615                 620                 


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
625                 630                 635                 640 


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
                645                 650                 655     


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
        675                 680                 685             


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
    690                 695                 700                 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala 
705                 710                 715                 720 


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
                725                 730                 735     


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile 
            740                 745                 750         


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
        755                 760                 765             


Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
    770                 775                 780                 


Arg 
785 


<210>  692
<211>  2142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2-FCHingeless/Y407R-OKT3

<400>  692
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaactgca cctgaactcc tggggggacc gtcagtcttc      780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      840

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      900

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      960

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1020

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1080

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac     1140

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1200

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1260

ggctccttct tcctcaggag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1320

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1380

tccctgtctc cgggtaaagg cggtggcgga tcccaggtgc agctggtgca gagcggaggc     1440

ggagtggtgc agcctggaag aagcctgcgc ctgagctgca aagcgagcgg ctataccttt     1500

acccgctata ccatgcattg ggtgcgccag gcgccgggca aaggcctgga atggattggc     1560

tatattaacc cgagccgcgg ctataccaac tataaccaga aagtgaaaga tcgctttacc     1620

attagcaccg ataaaagcaa aagcaccgcg tttctgcaga tggatagcct gcgcccggaa     1680

gataccgcgg tgtattattg cgcgcgctat tatgatgatc attattgcct ggattattgg     1740

ggccagggca ccaccctgac cgtgagcagc ggcggtggcg gatccggcgg tggcggatcc     1800

ggcggtggcg gatccgatat tcagatgacc cagagcccga gcagcctgag cgcgagcgtg     1860

ggcgatcgcg tgaccattac ctgcagcgcg agcagcagcg tgagctatat gaactggtat     1920

cagcagaccc cgggcaaagc gccgaaacgc tggatttatg ataccagcaa actggcgagc     1980

ggcgtgccga gccgctttag cggcagcggc agcggcaccg attatacctt taccattagc     2040

agcctgcagc cggaagatat tgcgacctat tattgccagc agtggagcag caacccgttt     2100

acctttggcc agggcaccaa actgcagatt acccgctgat aa                        2142


<210>  693
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2-FCHingeless/Y407R-OKT3

<400>  693

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Arg Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly 
465                 470                 475                 480 


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser 
                485                 490                 495     


Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro 
            500                 505                 510         


Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr 
        515                 520                 525             


Thr Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr Asp 
    530                 535                 540                 


Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu 
545                 550                 555                 560 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys 
                565                 570                 575     


Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
        595                 600                 605             


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    610                 615                 620                 


Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
625                 630                 635                 640 


Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
                645                 650                 655     


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
            660                 665                 670         


Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
        675                 680                 685             


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln 
    690                 695                 700                 


Gly Thr Lys Leu Gln Ile Thr Arg 
705                 710         


<210>  694
<211>  2316
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2-IgD/FCHingeless/Y407R-OKT3

<400>  694
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaactgag tctccaaagg cacaggcctc ctcagtgccc      780

actgcacaac cccaagcaga gggcagcctc gccaaggcaa ccacagcccc agccaccacc      840

cgtaacacag gaagaggcgg cgaagagaag aaaaaggaga aggagaaaga ggaacaagaa      900

gagagagaga caaagacacc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      960

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg     1020

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1080

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1140

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1200

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1260

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc     1320

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1380

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1440

ttcttcctca ggagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1500

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1560

tctccgggta aaggcggtgg cggatcccag gtgcagctgg tgcagagcgg aggcggagtg     1620

gtgcagcctg gaagaagcct gcgcctgagc tgcaaagcga gcggctatac ctttacccgc     1680

tataccatgc attgggtgcg ccaggcgccg ggcaaaggcc tggaatggat tggctatatt     1740

aacccgagcc gcggctatac caactataac cagaaagtga aagatcgctt taccattagc     1800

accgataaaa gcaaaagcac cgcgtttctg cagatggata gcctgcgccc ggaagatacc     1860

gcggtgtatt attgcgcgcg ctattatgat gatcattatt gcctggatta ttggggccag     1920

ggcaccaccc tgaccgtgag cagcggcggt ggcggatccg gcggtggcgg atccggcggt     1980

ggcggatccg atattcagat gacccagagc ccgagcagcc tgagcgcgag cgtgggcgat     2040

cgcgtgacca ttacctgcag cgcgagcagc agcgtgagct atatgaactg gtatcagcag     2100

accccgggca aagcgccgaa acgctggatt tatgatacca gcaaactggc gagcggcgtg     2160

ccgagccgct ttagcggcag cggcagcggc accgattata cctttaccat tagcagcctg     2220

cagccggaag atattgcgac ctattattgc cagcagtgga gcagcaaccc gtttaccttt     2280

ggccagggca ccaaactgca gattacccgc tgataa                               2316


<210>  695
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2-IgD/FCHingeless/Y407R-OKT3

<400>  695

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Glu Ser Pro Lys Ala Gln Ala 
                245                 250                 255     


Ser Ser Val Pro Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys 
            260                 265                 270         


Ala Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu 
        275                 280                 285             


Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr 
    290                 295                 300                 


Lys Thr Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
305                 310                 315                 320 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                325                 330                 335     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            340                 345                 350         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        355                 360                 365             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    370                 375                 380                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
385                 390                 395                 400 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                405                 410                 415     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            420                 425                 430         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        435                 440                 445             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    450                 455                 460                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
465                 470                 475                 480 


Phe Phe Leu Arg Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                485                 490                 495     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            500                 505                 510         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
        515                 520                 525             


Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly 
    530                 535                 540                 


Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
545                 550                 555                 560 


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                565                 570                 575     


Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys 
            580                 585                 590         


Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys Ser Lys Ser Thr Ala 
        595                 600                 605             


Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
    610                 615                 620                 


Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln 
625                 630                 635                 640 


Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                645                 650                 655     


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            660                 665                 670         


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala 
        675                 680                 685             


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys 
    690                 695                 700                 


Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
705                 710                 715                 720 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr 
                725                 730                 735     


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
            740                 745                 750         


Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile 
        755                 760                 765             


Thr Arg 
    770 


<210>  696
<211>  1665
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2-IgD-OKT3

<400>  696
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaactgag tctccaaagg cacaggcctc ctcagtgccc      780

actgcacaac cccaagcaga gggcagcctc gccaaggcaa ccacagcccc agccaccacc      840

cgtaacacag gaagaggcgg cgaagagaag aaaaaggaga aggagaaaga ggaacaagaa      900

gagagagaga caaagacacc aggcggtggc ggatcccagg tgcagctggt gcagagcgga      960

ggcggagtgg tgcagcctgg aagaagcctg cgcctgagct gcaaagcgag cggctatacc     1020

tttacccgct ataccatgca ttgggtgcgc caggcgccgg gcaaaggcct ggaatggatt     1080

ggctatatta acccgagccg cggctatacc aactataacc agaaagtgaa agatcgcttt     1140

accattagca ccgataaaag caaaagcacc gcgtttctgc agatggatag cctgcgcccg     1200

gaagataccg cggtgtatta ttgcgcgcgc tattatgatg atcattattg cctggattat     1260

tggggccagg gcaccaccct gaccgtgagc agcggcggtg gcggatccgg cggtggcgga     1320

tccggcggtg gcggatccga tattcagatg acccagagcc cgagcagcct gagcgcgagc     1380

gtgggcgatc gcgtgaccat tacctgcagc gcgagcagca gcgtgagcta tatgaactgg     1440

tatcagcaga ccccgggcaa agcgccgaaa cgctggattt atgataccag caaactggcg     1500

agcggcgtgc cgagccgctt tagcggcagc ggcagcggca ccgattatac ctttaccatt     1560

agcagcctgc agccggaaga tattgcgacc tattattgcc agcagtggag cagcaacccg     1620

tttacctttg gccagggcac caaactgcag attacccgct gataa                     1665


<210>  697
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2-IgD-OKT3

<400>  697

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Glu Ser Pro Lys Ala Gln Ala 
                245                 250                 255     


Ser Ser Val Pro Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys 
            260                 265                 270         


Ala Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu 
        275                 280                 285             


Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr 
    290                 295                 300                 


Lys Thr Pro Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
305                 310                 315                 320 


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala 
                325                 330                 335     


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala 
            340                 345                 350         


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly 
        355                 360                 365             


Tyr Thr Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr 
    370                 375                 380                 


Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro 
385                 390                 395                 400 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
                405                 410                 415     


Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
        435                 440                 445             


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
    450                 455                 460                 


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
465                 470                 475                 480 


Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr 
                485                 490                 495     


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            500                 505                 510         


Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
        515                 520                 525             


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
    530                 535                 540                 


Gln Gly Thr Lys Leu Gln Ile Thr Arg 
545                 550             


<210>  698
<211>  1620
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2-X4-OKT3

<400>  698
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaactgac aagacgcaca ccaagccacc taaaccagct      780

ccagaactgc tcggaggtcc tggcaccgga accggaggac ctaccatcaa accacctaag      840

ccacctaagc ctgctcctaa cctgctcgga ggacctggcg gtggcggatc ccaggtgcag      900

ctggtgcaga gcggaggcgg agtggtgcag cctggaagaa gcctgcgcct gagctgcaaa      960

gcgagcggct atacctttac ccgctatacc atgcattggg tgcgccaggc gccgggcaaa     1020

ggcctggaat ggattggcta tattaacccg agccgcggct ataccaacta taaccagaaa     1080

gtgaaagatc gctttaccat tagcaccgat aaaagcaaaa gcaccgcgtt tctgcagatg     1140

gatagcctgc gcccggaaga taccgcggtg tattattgcg cgcgctatta tgatgatcat     1200

tattgcctgg attattgggg ccagggcacc accctgaccg tgagcagcgg cggtggcgga     1260

tccggcggtg gcggatccgg cggtggcgga tccgatattc agatgaccca gagcccgagc     1320

agcctgagcg cgagcgtggg cgatcgcgtg accattacct gcagcgcgag cagcagcgtg     1380

agctatatga actggtatca gcagaccccg ggcaaagcgc cgaaacgctg gatttatgat     1440

accagcaaac tggcgagcgg cgtgccgagc cgctttagcg gcagcggcag cggcaccgat     1500

tataccttta ccattagcag cctgcagccg gaagatattg cgacctatta ttgccagcag     1560

tggagcagca acccgtttac ctttggccag ggcaccaaac tgcagattac ccgctgataa     1620


<210>  699
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2-X4-OKT3

<400>  699

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Asp Lys Thr His Thr Lys Pro 
                245                 250                 255     


Pro Lys Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Thr Gly 
            260                 265                 270         


Gly Pro Thr Ile Lys Pro Pro Lys Pro Pro Lys Pro Ala Pro Asn Leu 
        275                 280                 285             


Leu Gly Gly Pro Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
    290                 295                 300                 


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys 
305                 310                 315                 320 


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
            340                 345                 350         


Gly Tyr Thr Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser 
        355                 360                 365             


Thr Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg 
    370                 375                 380                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
385                 390                 395                 400 


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
            420                 425                 430         


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
        435                 440                 445             


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
    450                 455                 460                 


Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
465                 470                 475                 480 


Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
                485                 490                 495     


Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp 
            500                 505                 510         


Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe 
        515                 520                 525             


Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg 
    530                 535             


<210>  700
<211>  2910
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2-MMP9

<400>  700
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaactggc ggtggcggat ccagcctctg gcagcccctg      780

gtcctggtgc tcctggtgct gggctgctgc tttgctgccc ccagacagcg ccagtccacc      840

cttgtgctct tccctggaga cctgagaacc aatctcaccg acaggcagct ggcagaggaa      900

tacctgtacc gctatggtta cactcgggtg gcagagatgc gtggagagtc gaaatctctg      960

gggcctgcgc tgctgcttct ccagaagcaa ctgtccctgc ccgagaccgg tgagctggat     1020

agcgccacgc tgaaggccat gcgaacccca cggtgcgggg tcccagacct gggcagattc     1080

caaacctttg agggcgacct caagtggcac caccacaaca tcacctattg gatccaaaac     1140

tactcggaag acttgccgcg ggcggtgatt gacgacgcct ttgcccgcgc cttcgcactg     1200

tggagcgcgg tgacgccgct caccttcact cgcgtgtaca gccgggacgc agacatcgtc     1260

atccagtttg gtgtcgcgga gcacggagac gggtatccct tcgacgggaa ggacgggctc     1320

ctggcacacg cctttcctcc tggccccggc attcagggag acgcccattt cgacgatgac     1380

gagttgtggt ccctgggcaa gggcgtcgtg gttccaactc ggtttggaaa cgcagatggc     1440

gcggcctgcc acttcccctt catcttcgag ggccgctcct actctgcctg caccaccgac     1500

ggtcgctccg acggcttgcc ctggtgcagt accacggcca actacgacac cgacgaccgg     1560

tttggcttct gccccagcga gagactctac acccaggacg gcaatgctga tgggaaaccc     1620

tgccagtttc cattcatctt ccaaggccaa tcctactccg cctgcaccac ggacggtcgc     1680

tccgacggct accgctggtg cgccaccacc gccaactacg accgggacaa gctcttcggc     1740

ttctgcccga cccgagctga ctcgacggtg atggggggca actcggcggg ggagctgtgc     1800

gtcttcccct tcactttcct gggtaaggag tactcgacct gtaccagcga gggccgcgga     1860

gatgggcgcc tctggtgcgc taccacctcg aactttgaca gcgacaagaa gtggggcttc     1920

tgcccggacc aaggatacag tttgttcctc gtggcggcgc atgagttcgg ccacgcgctg     1980

ggcttagatc attcctcagt gccggaggcg ctcatgtacc ctatgtaccg cttcactgag     2040

gggcccccct tgcataagga cgacgtgaat ggcatccggc acctctatgg tcctcgccct     2100

gaacctgagc cacggcctcc aaccaccacc acaccgcagc ccacggctcc cccgacggtc     2160

tgccccaccg gaccccccac tgtccacccc tcagagcgcc ccacagctgg ccccacaggt     2220

cccccctcag ctggccccac aggtcccccc actgctggcc cttctacggc cactactgtg     2280

cctttgagtc cggtggacga tgcctgcaac gtgaacatct tcgacgccat cgcggagatt     2340

gggaaccagc tgtatttgtt caaggatggg aagtactggc gattctctga gggcaggggg     2400

agccggccgc agggcccctt ccttatcgcc gacaagtggc ccgcgctgcc ccgcaagctg     2460

gactcggtct ttgaggagcg gctctccaag aagcttttct tcttctctgg gcgccaggtg     2520

tgggtgtaca caggcgcgtc ggtgctgggc ccgaggcgtc tggacaagct gggcctggga     2580

gccgacgtgg cccaggtgac cggggccctc cggagtggca gggggaagat gctgctgttc     2640

agcgggcggc gcctctggag gttcgacgtg aaggcgcaga tggtggatcc ccggagcgcc     2700

agcgaggtgg accggatgtt ccccggggtg cctttggaca cgcacgacgt cttccagtac     2760

cgagagaaag cctatttctg ccaggaccgc ttctactggc gcgtgagttc ccggagtgag     2820

ttgaaccagg tggaccaagt gggctacgtg acctatgaca tcctgcagtg ccctgaggac     2880

gattacaagg atgacgacga taagtgataa                                      2910


<210>  701
<211>  968
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2-MMP9

<400>  701

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly Gly Ser Ser Leu 
                245                 250                 255     


Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys Cys Phe Ala 
            260                 265                 270         


Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro Gly Asp Leu 
        275                 280                 285             


Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr Leu Tyr Arg 
    290                 295                 300                 


Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser Lys Ser Leu 
305                 310                 315                 320 


Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu Pro Glu Thr 
                325                 330                 335     


Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr Pro Arg Cys 
            340                 345                 350         


Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly Asp Leu Lys 
        355                 360                 365             


Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr Ser Glu Asp 
    370                 375                 380                 


Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala Phe Ala Leu 
385                 390                 395                 400 


Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr Ser Arg Asp 
                405                 410                 415     


Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly Asp Gly Tyr 
            420                 425                 430         


Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe Pro Pro Gly 
        435                 440                 445             


Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu Leu Trp Ser 
    450                 455                 460                 


Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn Ala Asp Gly 
465                 470                 475                 480 


Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser Tyr Ser Ala 
                485                 490                 495     


Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys Ser Thr Thr 
            500                 505                 510         


Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro Ser Glu Arg 
        515                 520                 525             


Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys Gln Phe Pro 
    530                 535                 540                 


Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg 
545                 550                 555                 560 


Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr Asp Arg Asp 
                565                 570                 575     


Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr Val Met Gly 
            580                 585                 590         


Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr Phe Leu Gly 
        595                 600                 605             


Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp Gly Arg Leu 
    610                 615                 620                 


Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys Trp Gly Phe 
625                 630                 635                 640 


Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala His Glu Phe 
                645                 650                 655     


Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu Ala Leu Met 
            660                 665                 670         


Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His Lys Asp Asp 
        675                 680                 685             


Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu Pro Glu Pro 
    690                 695                 700                 


Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro Pro Thr Val 
705                 710                 715                 720 


Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg Pro Thr Ala 
                725                 730                 735     


Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro Pro Thr Ala 
            740                 745                 750         


Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val Asp Asp Ala 
        755                 760                 765             


Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly Asn Gln Leu 
    770                 775                 780                 


Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu Gly Arg Gly 
785                 790                 795                 800 


Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp Pro Ala Leu 
                805                 810                 815     


Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Arg Leu Ser Lys Lys Leu 
            820                 825                 830         


Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly Ala Ser Val 
        835                 840                 845             


Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala Asp Val Ala 
    850                 855                 860                 


Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met Leu Leu Phe 
865                 870                 875                 880 


Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln Met Val Asp 
                885                 890                 895     


Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly Val Pro Leu 
            900                 905                 910         


Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr Phe Cys Gln 
        915                 920                 925             


Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu Asn Gln Val 
    930                 935                 940                 


Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys Pro Glu Asp 
945                 950                 955                 960 


Asp Tyr Lys Asp Asp Asp Asp Lys 
                965             


<210>  702
<211>  1821
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2-MMP9cat

<400>  702
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaactggc ggtggcggat ccttccaaac ctttgagggc      780

gacctcaagt ggcaccacca caacatcacc tattggatcc aaaactactc ggaagacttg      840

ccgcgggcgg tgattgacga cgcctttgcc cgcgccttcg cactgtggag cgcggtgacg      900

ccgctcacct tcactcgcgt gtacagccgg gacgcagaca tcgtcatcca gtttggtgtc      960

gcggagcacg gagacgggta tcccttcgac gggaaggacg ggctcctggc acacgccttt     1020

cctcctggcc ccggcattca gggagacgcc catttcgacg atgacgagtt gtggtccctg     1080

ggcaagggcg tcgtggttcc aactcggttt ggaaacgcag atggcgcggc ctgccacttc     1140

cccttcatct tcgagggccg ctcctactct gcctgcacca ccgacggtcg ctccgacggc     1200

ttgccctggt gcagtaccac ggccaactac gacaccgacg accggtttgg cttctgcccc     1260

agcgagagac tctacaccca ggacggcaat gctgatggga aaccctgcca gtttccattc     1320

atcttccaag gccaatccta ctccgcctgc accacggacg gtcgctccga cggctaccgc     1380

tggtgcgcca ccaccgccaa ctacgaccgg gacaagctct tcggcttctg cccgacccga     1440

gctgactcga cggtgatggg gggcaactcg gcgggggagc tgtgcgtctt ccccttcact     1500

ttcctgggta aggagtactc gacctgtacc agcgagggcc gcggagatgg gcgcctctgg     1560

tgcgctacca cctcgaactt tgacagcgac aagaagtggg gcttctgccc ggaccaagga     1620

tacagtttgt tcctcgtggc ggcgcatgag ttcggccacg cgctgggctt agatcattcc     1680

tcagtgccgg aggcgctcat gtaccctatg taccgcttca ctgaggggcc ccccttgcat     1740

aaggacgacg tgaatggcat ccggcacctc tatggtcctc gccctgaacc tgattacaag     1800

gatgacgacg ataagtgata a                                               1821


<210>  703
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2-MMP9cat

<400>  703

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly Gly Ser Phe Gln 
                245                 250                 255     


Thr Phe Glu Gly Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp 
            260                 265                 270         


Ile Gln Asn Tyr Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala 
        275                 280                 285             


Phe Ala Arg Ala Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe 
    290                 295                 300                 


Thr Arg Val Tyr Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val 
305                 310                 315                 320 


Ala Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu 
                325                 330                 335     


Ala His Ala Phe Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe 
            340                 345                 350         


Asp Asp Asp Glu Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr 
        355                 360                 365             


Arg Phe Gly Asn Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe 
    370                 375                 380                 


Glu Gly Arg Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly 
385                 390                 395                 400 


Leu Pro Trp Cys Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe 
                405                 410                 415     


Gly Phe Cys Pro Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp 
            420                 425                 430         


Gly Lys Pro Cys Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser 
        435                 440                 445             


Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr 
    450                 455                 460                 


Thr Ala Asn Tyr Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg 
465                 470                 475                 480 


Ala Asp Ser Thr Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val 
                485                 490                 495     


Phe Pro Phe Thr Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu 
            500                 505                 510         


Gly Arg Gly Asp Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp 
        515                 520                 525             


Ser Asp Lys Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe 
    530                 535                 540                 


Leu Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser 
545                 550                 555                 560 


Ser Val Pro Glu Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly 
                565                 570                 575     


Pro Pro Leu His Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly 
            580                 585                 590         


Pro Arg Pro Glu Pro Asp Tyr Lys Asp Asp Asp Asp Lys 
        595                 600                 605 


<210>  704
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  [G4S1]x2 linker sequence:

<400>  704
ggcggtggcg gatccggcgg tggcggatcc                                        30


<210>  705
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [G4S1]x2 linker sequence:

<400>  705

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  706
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  [G4S1]x3 linker sequence:

<400>  706
ggcggtggcg gatccggcgg tggcggatcc ggcggtggcg gatcc                       45


<210>  707
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [G4S1]x3 linker sequence:

<400>  707

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  708
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Long GS linker sequence:

<400>  708
ggcggtggaa gcggcggtgg cggatccggc agcggcggaa gcggcggtgg cggatccggc       60

ggtgga                                                                  66


<210>  709
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Long GS linker sequence

<400>  709

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly 
            20          


<210>  710
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13 aa GS linker sequence

<400>  710
ggcggtggat ccggcggtgg cggatccggc ggtggatcc                              39


<210>  711
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13 aa GS linker sequence

<400>  711

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10              


<210>  712
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8 aa GS linker sequence

<400>  712
ggcggttccg gcggtggatc cgga                                              24


<210>  713
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8 aa GS linker sequence

<400>  713

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  714
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12 aa GS linker sequence

<400>  714
ggcggttccg gcggtggatc cggcggtggc ggatccgga                              39


<210>  715
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12 aa GS linker sequence

<400>  715

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10          


<210>  716
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  24 aa GS linker sequence

<400>  716
ggcggttccg gcggtggatc cggcggtggc ggatccggag gcggttccgg cggtggatcc       60

ggcggtggcg gatccgga                                                     78


<210>  717
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  24 aa GS linker sequence

<400>  717

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser Gly 
            20                  


<210>  718
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD8/CD8/4-1BB/CD3z CAR44

<400>  718
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact acaacaaccc ctgcccccag acctcctacc      840

ccagccccta caattgccag ccagcctctg agcctgaggc ccgaggcttg tagacctgct      900

gctggcggag ccgtgcacac cagaggactg gatttcgcct gcgacatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag     1200

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1260

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1320

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1440

acctacgacg cccttcacat gcaggccctg ccccctcgct gataa                     1485


<210>  719
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD8/CD8/4-1BB/CD3z CAR44

<400>  719

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  720
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T IgK C2 CD8/CD8/4-1BB/CD3z CAR45

<400>  720
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc      120

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      180

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      240

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      300

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      360

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      420

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      540

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      600

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      660

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      720

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      780

gggaccaagg tggagatcaa acgaactaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgctgat aa                        1482


<210>  721
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T IgK C2 CD8/CD8/4-1BB/CD3z CAR45

<400>  721

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr 
65                  70                  75                  80  


Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe 
        115                 120                 125             


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
            180                 185                 190         


Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala 
225                 230                 235                 240 


Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  722
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 op CD8/CD8/4-1BB/CD3z CAR46

<400>  722
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtgc agctggtgga atctggcggc ggactcgtga agcctggcgg ctctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcggctacg ccatgagctg ggtgcgccag      180

gctcctggca aaggcctgga atgggtgtcc accatctcta gcggcggcac ctacatctac      240

taccccgaca gcgtgaaggg ccggttcacc atcagccggg acaacgccaa gaacagcctg      300

tacctgcaga tgaactccct gcgggccgag gacaccgccg tgtactattg tgctagactg      360

ggcggcgaca actactacga gtacttcgac gtgtggggca agggcaccac cgtgacagtg      420

tctagcggag gcggaggatc aggcggcgga ggaagtggcg gagggggatc tgatatcgtg      480

ctgacccaga gccctgccag cctggctgtg tctcctggac agagggccac catcacctgt      540

cgggccagca agagcgtgtc cacctccggc tacagctaca tgcactggta tcagcagaag      600

cccggccagc cccccaagct gctgatctac ctggccagca acctggaaag cggcgtgccc      660

gctagatttt ccggctctgg cagcggcacc gacttcaccc tgaccatcaa ccccgtggaa      720

gccaacgaca ccgccaatta ctactgccag cacagcagag agctgccctt caccttcggc      780

ggaggcacca aggtggaaat caagcggacc acaacaaccc ctgcccccag acctcctacc      840

ccagccccta caattgccag ccagcctctg agcctgaggc ccgaggcttg tagacctgct      900

gctggcggag ccgtgcacac cagaggactg gatttcgcct gcgacatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag     1200

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1260

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1320

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1440

acctacgacg cccttcacat gcaggccctg ccccctcgct gataa                     1485


<210>  723
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 op CD8/CD8/4-1BB/CD3z CAR46

<400>  723

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  724
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T IgK C2 op CD8/CD8/4-1BB/CD3z CAR47

<400>  724
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gaagtgcagc tggtggaatc tggcggcgga ctcgtgaagc ctggcggctc tctgagactg      120

agctgtgccg ccagcggctt cacctttagc ggctacgcca tgagctgggt gcgccaggct      180

cctggcaaag gcctggaatg ggtgtccacc atctctagcg gcggcaccta catctactac      240

cccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgcg ggccgaggac accgccgtgt actattgtgc tagactgggc      360

ggcgacaact actacgagta cttcgacgtg tggggcaagg gcaccaccgt gacagtgtct      420

agcggaggcg gaggatcagg cggcggagga agtggcggag ggggatctga tatcgtgctg      480

acccagagcc ctgccagcct ggctgtgtct cctggacaga gggccaccat cacctgtcgg      540

gccagcaaga gcgtgtccac ctccggctac agctacatgc actggtatca gcagaagccc      600

ggccagcccc ccaagctgct gatctacctg gccagcaacc tggaaagcgg cgtgcccgct      660

agattttccg gctctggcag cggcaccgac ttcaccctga ccatcaaccc cgtggaagcc      720

aacgacaccg ccaattacta ctgccagcac agcagagagc tgcccttcac cttcggcgga      780

ggcaccaagg tggaaatcaa gcggaccaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgctgat aa                        1482


<210>  725
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T IgK C2 op CD8/CD8/4-1BB/CD3z CAR47

<400>  725

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr 
65                  70                  75                  80  


Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe 
        115                 120                 125             


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
            180                 185                 190         


Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala 
225                 230                 235                 240 


Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  726
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD8/CD8/4-1BB/CD3z op CAR48

<400>  726
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtgc agctggtgga atctggcggc ggactcgtga agcctggcgg ctctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcggctacg ccatgagctg ggtgcgccag      180

gctcctggca aaggcctgga atgggtgtcc accatctcta gcggcggcac ctacatctac      240

taccccgaca gcgtgaaggg ccggttcacc atcagccggg acaacgccaa gaacagcctg      300

tacctgcaga tgaactccct gcgggccgag gacaccgccg tgtactattg tgctagactg      360

ggcggcgaca actactacga gtacttcgac gtgtggggca agggcaccac cgtgacagtg      420

tctagcggag gcggaggatc aggcggcgga ggaagtggcg gagggggatc tgatatcgtg      480

ctgacccaga gccctgccag cctggctgtg tctcctggac agagggccac catcacctgt      540

cgggccagca agagcgtgtc cacctccggc tacagctaca tgcactggta tcagcagaag      600

cccggccagc cccccaagct gctgatctac ctggccagca acctggaaag cggcgtgccc      660

gctagatttt ccggctctgg cagcggcacc gacttcaccc tgaccatcaa ccccgtggaa      720

gccaacgaca ccgccaatta ctactgccag cacagcagag agctgccctt caccttcggc      780

ggaggcacca aggtggaaat caagcggacc acaacaaccc ctgcccccag acctcctacc      840

ccagccccta caattgccag ccagcctctg agcctgaggc ccgaggcttg tagacctgct      900

gctggcggag ccgtgcacac cagaggactg gatttcgcct gcgacatcta catctgggcc      960

cctctggccg gcacatgtgg cgtgctgctg ctgagcctcg tgatcaccct gtactgcaag     1020

cggggcagaa agaagctgct gtacatcttc aagcagccct tcatgcggcc cgtgcagacc     1080

acccaggaag aggacggctg ctcctgcaga ttccccgagg aagaagaagg cggctgcgag     1140

ctgagagtga agttcagcag atccgccgac gcccctgcct acaagcaggg ccagaaccag     1200

ctgtacaacg agctgaacct gggcagacgg gaagagtacg acgtgctgga caagcggaga     1260

ggcagggacc ctgagatggg cggcaagccc agaagaaaga acccccagga aggcctgtat     1320

aacgaactgc agaaagacaa gatggccgag gcctacagcg agatcggaat gaagggcgag     1380

cggagaagag gcaagggcca cgatggcctg taccagggcc tgagcaccgc caccaaggac     1440

acctatgacg ccctgcacat gcaggccctg cctcccagat gataa                     1485


<210>  727
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD8/CD8/4-1BB/CD3z op CAR48

<400>  727

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  728
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T IgK C2 CD8/CD8/4-1BB/CD3z op CAR49

<400>  728
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gaagtgcagc tggtggaatc tggcggcgga ctcgtgaagc ctggcggctc tctgagactg      120

agctgtgccg ccagcggctt cacctttagc ggctacgcca tgagctgggt gcgccaggct      180

cctggcaaag gcctggaatg ggtgtccacc atctctagcg gcggcaccta catctactac      240

cccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgcg ggccgaggac accgccgtgt actattgtgc tagactgggc      360

ggcgacaact actacgagta cttcgacgtg tggggcaagg gcaccaccgt gacagtgtct      420

agcggaggcg gaggatcagg cggcggagga agtggcggag ggggatctga tatcgtgctg      480

acccagagcc ctgccagcct ggctgtgtct cctggacaga gggccaccat cacctgtcgg      540

gccagcaaga gcgtgtccac ctccggctac agctacatgc actggtatca gcagaagccc      600

ggccagcccc ccaagctgct gatctacctg gccagcaacc tggaaagcgg cgtgcccgct      660

agattttccg gctctggcag cggcaccgac ttcaccctga ccatcaaccc cgtggaagcc      720

aacgacaccg ccaattacta ctgccagcac agcagagagc tgcccttcac cttcggcgga      780

ggcaccaagg tggaaatcaa gcggaccaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcccct      960

ctggccggca catgtggcgt gctgctgctg agcctcgtga tcaccctgta ctgcaagcgg     1020

ggcagaaaga agctgctgta catcttcaag cagcccttca tgcggcccgt gcagaccacc     1080

caggaagagg acggctgctc ctgcagattc cccgaggaag aagaaggcgg ctgcgagctg     1140

agagtgaagt tcagcagatc cgccgacgcc cctgcctaca agcagggcca gaaccagctg     1200

tacaacgagc tgaacctggg cagacgggaa gagtacgacg tgctggacaa gcggagaggc     1260

agggaccctg agatgggcgg caagcccaga agaaagaacc cccaggaagg cctgtataac     1320

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggaatgaa gggcgagcgg     1380

agaagaggca agggccacga tggcctgtac cagggcctga gcaccgccac caaggacacc     1440

tatgacgccc tgcacatgca ggccctgcct cccagatgat aa                        1482


<210>  729
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T IgK C2 CD8/CD8/4-1BB/CD3z op CAR49

<400>  729

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr 
65                  70                  75                  80  


Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe 
        115                 120                 125             


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
            180                 185                 190         


Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala 
225                 230                 235                 240 


Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  730
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/4-1BB/CD3z CAR50

<400>  730
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact tcgggacagg tcctgctgga atccaacatc      840

aaggttctgc ccacatggtc caccccggtg cagccaatgg ccctgattgt gctggggggc      900

gtcgccggcc tcctgctttt cattgggcta ggcatcttct tcaaacgggg cagaaagaaa      960

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1020

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     1080

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1140

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1200

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1260

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1320

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1380

cacatgcagg ccctgccccc tcgctgataa                                      1410


<210>  731
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/4-1BB/CD3z CAR50

<400>  731

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Ser Gly 
            260                 265                 270         


Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr 
        275                 280                 285             


Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
    290                 295                 300                 


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Lys Arg Gly Arg Lys Lys 
305                 310                 315                 320 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                325                 330                 335     


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            340                 345                 350         


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                405                 410                 415     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            420                 425                 430         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        435                 440                 445             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    450                 455                 460                 


Leu Pro Pro Arg 
465             


<210>  732
<211>  2046
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 FC/CD8/4-1BB/CD3z "Fc" CAR53

<400>  732
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact gagcccaaat cttgtgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggtaaaatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg     1560

gttatcaccc tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca     1620

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1680

gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg     1740

tacaagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     1800

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag     1860

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt     1920

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt     1980

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc     2040

tgataa                                                                2046


<210>  733
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 FC/CD8/4-1BB/CD3z "Fc" CAR53

<400>  733

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            500                 505                 510         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
        515                 520                 525             


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
    530                 535                 540                 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
545                 550                 555                 560 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
                565                 570                 575     


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            580                 585                 590         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        595                 600                 605             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    610                 615                 620                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
625                 630                 635                 640 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                645                 650                 655     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            660                 665                 670         


His Met Gln Ala Leu Pro Pro Arg 
        675                 680 


<210>  734
<211>  2220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 IgD/FC/CD8/4-1BB/CD3z "IgD-Fc" CAR54

<400>  734
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact gagtctccaa aggcacaggc ctcctcagtg      840

cccactgcac aaccccaagc agagggcagc ctcgccaagg caaccacagc cccagccacc      900

acccgtaaca caggaagagg cggcgaagag aagaaaaagg agaaggagaa agaggaacaa      960

gaagagagag agacaaagac accagagccc aaatcttgtg acaaaactca cacatgccca     1020

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc     1080

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1140

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1200

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1260

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1320

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1380

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1440

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1500

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1560

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1620

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1680

atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     1740

accctttact gcaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1800

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1860

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     1920

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1980

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     2040

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     2100

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     2160

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctgataa     2220


<210>  735
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 IgD/FC/CD8/4-1BB/CD3z "IgD-Fc" CAR54

<400>  735

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Glu Ser 
            260                 265                 270         


Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln Ala Glu 
        275                 280                 285             


Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr 
    290                 295                 300                 


Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln 
305                 310                 315                 320 


Glu Glu Arg Glu Thr Lys Thr Pro Glu Pro Lys Ser Cys Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                565                 570                 575     


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
            580                 585                 590         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        595                 600                 605             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    610                 615                 620                 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
625                 630                 635                 640 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                645                 650                 655     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            660                 665                 670         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        675                 680                 685             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    690                 695                 700                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
705                 710                 715                 720 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                725                 730                 735     


Pro Arg 
        


<210>  736
<211>  2001
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 FCHingeless Y407R/CD8/4-1BB/CD3z "FcH" CAR55

<400>  736
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact gcacctgaac tcctgggggg accgtcagtc      840

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      900

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      960

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     1020

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1080

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1140

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1200

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1260

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1320

gacggctcct tcttcctcag gagcaagctc accgtggaca agagcaggtg gcagcagggg     1380

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1440

ctctccctgt ctccgggtaa aatctacatc tgggcgccct tggccgggac ttgtggggtc     1500

cttctcctgt cactggttat caccctttac tgcaaacggg gcagaaagaa actcctgtat     1560

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1620

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     1680

gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga     1740

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1800

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1860

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1920

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1980

gccctgcccc ctcgctgata a                                               2001


<210>  737
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 FCHingeless Y407R/CD8/4-1BB/CD3z "FcH" CAR55

<400>  737

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Ala Pro 
            260                 265                 270         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        275                 280                 285             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    290                 295                 300                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
305                 310                 315                 320 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                325                 330                 335     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            340                 345                 350         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        355                 360                 365             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    370                 375                 380                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
385                 390                 395                 400 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                405                 410                 415     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            420                 425                 430         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Arg Ser 
        435                 440                 445             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    450                 455                 460                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
465                 470                 475                 480 


Leu Ser Leu Ser Pro Gly Lys Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                485                 490                 495     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
            500                 505                 510         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        515                 520                 525             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    530                 535                 540                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
545                 550                 555                 560 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                565                 570                 575     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            580                 585                 590         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        595                 600                 605             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    610                 615                 620                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
625                 630                 635                 640 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                645                 650                 655     


Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665 


<210>  738
<211>  2175
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 IgD/FCHingeless Y407R/CD8/4-1BB/CD3z "IgD FcH" CAR56

<400>  738
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact gagtctccaa aggcacaggc ctcctcagtg      840

cccactgcac aaccccaagc agagggcagc ctcgccaagg caaccacagc cccagccacc      900

acccgtaaca caggaagagg cggcgaagag aagaaaaagg agaaggagaa agaggaacaa      960

gaagagagag agacaaagac accagcacct gaactcctgg ggggaccgtc agtcttcctc     1020

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1080

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1140

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1200

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1260

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1320

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1380

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1440

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1500

tccttcttcc tcaggagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1560

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1620

ctgtctccgg gtaaaatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc     1680

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc     1740

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     1800

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1860

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1920

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1980

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     2040

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     2100

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     2160

ccccctcgct gataa                                                      2175


<210>  739
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 IgD/FCHingeless Y407R/CD8/4-1BB/CD3z "IgD FcH" CAR56

<400>  739

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Glu Ser 
            260                 265                 270         


Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln Ala Glu 
        275                 280                 285             


Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr 
    290                 295                 300                 


Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln 
305                 310                 315                 320 


Glu Glu Arg Glu Thr Lys Thr Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                325                 330                 335     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            340                 345                 350         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        355                 360                 365             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    370                 375                 380                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
385                 390                 395                 400 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                405                 410                 415     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            420                 425                 430         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        435                 440                 445             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    450                 455                 460                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
465                 470                 475                 480 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                485                 490                 495     


Asp Ser Asp Gly Ser Phe Phe Leu Arg Ser Lys Leu Thr Val Asp Lys 
            500                 505                 510         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        515                 520                 525             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    530                 535                 540                 


Lys Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
545                 550                 555                 560 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                565                 570                 575     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            580                 585                 590         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        595                 600                 605             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    610                 615                 620                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
625                 630                 635                 640 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                645                 650                 655     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            660                 665                 670         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        675                 680                 685             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    690                 695                 700                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
705                 710                 715                 720 


Pro Pro Arg 
            


<210>  740
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 IgD/CD8/4-1BB/CD3z "IgD" CAR57

<400>  740
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact gagtctccaa aggcacaggc ctcctcagtg      840

cccactgcac aaccccaagc agagggcagc ctcgccaagg caaccacagc cccagccacc      900

acccgtaaca caggaagagg cggcgaagag aagaaaaagg agaaggagaa agaggaacaa      960

gaagagagag agacaaagac accaatctac atctgggcgc ccttggccgg gacttgtggg     1020

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1080

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1140

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1200

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1260

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1320

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1380

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1440

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1500

caggccctgc cccctcgctg ataa                                            1524


<210>  741
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 IgD/CD8/4-1BB/CD3z "IgD" CAR57

<400>  741

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Glu Ser 
            260                 265                 270         


Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln Ala Glu 
        275                 280                 285             


Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr 
    290                 295                 300                 


Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln 
305                 310                 315                 320 


Glu Glu Arg Glu Thr Lys Thr Pro Ile Tyr Ile Trp Ala Pro Leu Ala 
                325                 330                 335     


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            340                 345                 350         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        355                 360                 365             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    370                 375                 380                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
385                 390                 395                 400 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
                405                 410                 415     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            420                 425                 430         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        435                 440                 445             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    450                 455                 460                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
465                 470                 475                 480 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                485                 490                 495     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505     


<210>  742
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 X4/CD8/4-1BB/CD3z "X4" CAR58

<400>  742
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact gacaagacgc acaccaagcc acctaaacca      840

gctccagaac tgctcggagg tcctggcacc ggaaccggag gacctaccat caaaccacct      900

aagccaccta agcctgctcc taacctgctc ggaggaccta tctacatctg ggcgcccttg      960

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgctgataa                            1479


<210>  743
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 X4/CD8/4-1BB/CD3z "X4" CAR58

<400>  743

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Asp Lys 
            260                 265                 270         


Thr His Thr Lys Pro Pro Lys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        275                 280                 285             


Gly Thr Gly Thr Gly Gly Pro Thr Ile Lys Pro Pro Lys Pro Pro Lys 
    290                 295                 300                 


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  744
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD8/CD4/41BB/CD3z CAR37

<400>  744
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtggcggagg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aaacgacaac cccggccccc agaccaccaa cgccagcccc caccatcgcc      840

agccaacccc tgtctctgag accagaagcc tgtaggcctg ccgccggtgg agctgtgcac      900

acaagaggac tggatttcgc ctgtgatatg gccctgattg tgctgggggg cgtcgccggc      960

ctcctgcttt tcattgggct aggcatcttc ttcaaaaggg gccgcaaaaa actcctttac     1020

atttttaagc agccttttat gaggccagta cagacgactc aagaggaaga cgggtgctca     1080

tgccgctttc ctgaggagga ggaaggaggg tgcgaactgc gcgttaagtt ctcccgatca     1140

gccgacgcgc ctgcttacaa gcagggccag aaccaactgt acaacgagct gaatctcggt     1200

agacgggaag agtacgacgt gttggacaaa cggagaggcc gcgacccaga aatgggcggc     1260

aagcctcgca ggaaaaaccc ccaggaggga ctgtacaatg agttgcagaa agataagatg     1320

gcagaagctt atagcgagat cggaatgaag ggggaaagga gacgagggaa aggacacgac     1380

ggcctttatc agggcctgtc cacagcaaca aaagatacgt atgacgccct ccatatgcag     1440

gcacttccac cacggtgata a                                               1461


<210>  745
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD8/CD4/41BB/CD3z CAR37

<400>  745

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly 
305                 310                 315                 320 


Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  746
<211>  1266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD4/CD4/CD3z sequence CAR23

<400>  746
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aatcgggaca ggtcctgctg gaatccaaca tcaaggttct gcccacatgg      840

tccaccccgg tgcagccaat ggccctgatt gtgctggggg gcgtcgccgg cctcctgctt      900

ttcattgggc taggcatctt cttccgcgtt aagttctccc gatcagccga cgcgcctgct      960

tacaagcagg gccagaacca actgtacaac gagctgaatc tcggtagacg ggaagagtac     1020

gacgtgttgg acaaacggag aggccgcgac ccagaaatgg gcggcaagcc tcgcaggaaa     1080

aacccccagg agggactgta caatgagttg cagaaagata agatggcaga agcttatagc     1140

gagatcggaa tgaaggggga aaggagacga gggaaaggac acgacggcct ttatcagggc     1200

ctgtccacag caacaaaaga tacgtatgac gccctccata tgcaggcact tccaccacgg     1260

tgataa                                                                1266


<210>  747
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD4/CD4/CD3z sequence CAR23

<400>  747

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Ser Gly Gln Val Leu Leu Glu Ser 
            260                 265                 270         


Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala 
        275                 280                 285             


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
    290                 295                 300                 


Gly Ile Phe Phe Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
305                 310                 315                 320 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                325                 330                 335     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            340                 345                 350         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        355                 360                 365             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    370                 375                 380                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
385                 390                 395                 400 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                405                 410                 415     


Leu Pro Pro Arg 
            420 


<210>  748
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD4/CD4/CD28/CD3z sequence CAR25

<400>  748
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aatcgggaca ggtcctgctg gaatccaaca tcaaggttct gcccacatgg      840

tccaccccgg tgcagccaat ggccctgatt gtgctggggg gcgtcgccgg cctcctgctt      900

ttcattgggc taggcatctt cttcagaagc aagcggtctc ggctcctgca ttctgattac      960

atgaacatga ccccaagaag accaggcccc accaggaaac attaccagcc ctacgctccg     1020

ccacgcgact tcgctgccta ccggtcccgc gttaagttct cccgatcagc cgacgcgcct     1080

gcttacaagc agggccagaa ccaactgtac aacgagctga atctcggtag acgggaagag     1140

tacgacgtgt tggacaaacg gagaggccgc gacccagaaa tgggcggcaa gcctcgcagg     1200

aaaaaccccc aggagggact gtacaatgag ttgcagaaag ataagatggc agaagcttat     1260

agcgagatcg gaatgaaggg ggaaaggaga cgagggaaag gacacgacgg cctttatcag     1320

ggcctgtcca cagcaacaaa agatacgtat gacgccctcc atatgcaggc acttccacca     1380

cggtgataa                                                             1389


<210>  749
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD4/CD4/CD28/CD3z sequence CAR25

<400>  749

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Ser Gly Gln Val Leu Leu Glu Ser 
            260                 265                 270         


Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala 
        275                 280                 285             


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
    290                 295                 300                 


Gly Ile Phe Phe Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
305                 310                 315                 320 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
                325                 330                 335     


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
            340                 345                 350         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
        355                 360                 365             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    370                 375                 380                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
385                 390                 395                 400 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                405                 410                 415     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            420                 425                 430         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        435                 440                 445             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460     


<210>  750
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD4/CD4/4-1BB/CD3z sequence CAR31

<400>  750
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aatcgggaca ggtcctgctg gaatccaaca tcaaggttct gcccacatgg      840

tccaccccgg tgcagccaat ggccctgatt gtgctggggg gcgtcgccgg cctcctgctt      900

ttcattgggc taggcatctt cttcaaaagg ggccgcaaaa aactccttta catttttaag      960

cagcctttta tgaggccagt acagacgact caagaggaag acgggtgctc atgccgcttt     1020

cctgaggagg aggaaggagg gtgcgaactg cgcgttaagt tctcccgatc agccgacgcg     1080

cctgcttaca agcagggcca gaaccaactg tacaacgagc tgaatctcgg tagacgggaa     1140

gagtacgacg tgttggacaa acggagaggc cgcgacccag aaatgggcgg caagcctcgc     1200

aggaaaaacc cccaggaggg actgtacaat gagttgcaga aagataagat ggcagaagct     1260

tatagcgaga tcggaatgaa gggggaaagg agacgaggga aaggacacga cggcctttat     1320

cagggcctgt ccacagcaac aaaagatacg tatgacgccc tccatatgca ggcacttcca     1380

ccacggtgat aa                                                         1392


<210>  751
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD4/CD4/4-1BB/CD3z sequence CAR31

<400>  751

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Ser Gly Gln Val Leu Leu Glu Ser 
            260                 265                 270         


Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala 
        275                 280                 285             


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
    290                 295                 300                 


Gly Ile Phe Phe Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
305                 310                 315                 320 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                325                 330                 335     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            340                 345                 350         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        355                 360                 365             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         


<210>  752
<211>  1377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD4/CD4/OX40/CD3z sequence

<400>  752
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aatcgggaca ggtcctgctg gaatccaaca tcaaggttct gcccacatgg      840

tccaccccgg tgcagccaat ggccctgatt gtgctggggg gcgtcgccgg cctcctgctt      900

ttcattgggc taggcatctt cttccggagg gaccagaggc tgccccccga tgcccacaag      960

ccccctgggg gaggcagttt ccggaccccc atccaagagg agcaggccga cgcccactcc     1020

accctggcca agatccgcgt taagttctcc cgatcagccg acgcgcctgc ttacaagcag     1080

ggccagaacc aactgtacaa cgagctgaat ctcggtagac gggaagagta cgacgtgttg     1140

gacaaacgga gaggccgcga cccagaaatg ggcggcaagc ctcgcaggaa aaacccccag     1200

gagggactgt acaatgagtt gcagaaagat aagatggcag aagcttatag cgagatcgga     1260

atgaaggggg aaaggagacg agggaaagga cacgacggcc tttatcaggg cctgtccaca     1320

gcaacaaaag atacgtatga cgccctccat atgcaggcac ttccaccacg gtgataa        1377


<210>  753
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD4/CD4/OX40/CD3z sequence

<400>  753

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Ser Gly Gln Val Leu Leu Glu Ser 
            260                 265                 270         


Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala 
        275                 280                 285             


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
    290                 295                 300                 


Gly Ile Phe Phe Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys 
305                 310                 315                 320 


Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                325                 330                 335     


Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser 
            340                 345                 350         


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        355                 360                 365             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    370                 375                 380                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
385                 390                 395                 400 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                405                 410                 415     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            420                 425                 430         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        435                 440                 445             


Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455         


<210>  754
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD4/CD4/CD28/4-1BB/CD3z sequence CAR38

<400>  754
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aatcgggaca ggtcctgctg gaatccaaca tcaaggttct gcccacatgg      840

tccaccccgg tgcagccaat ggccctgatt gtgctggggg gcgtcgccgg cctcctgctt      900

ttcattgggc taggcatctt cttcagaagc aagcggtctc ggctcctgca ttctgattac      960

atgaacatga ccccaagaag accaggcccc accaggaaac attaccagcc ctacgctccg     1020

ccacgcgact tcgctgccta ccggtccaaa aggggccgca aaaaactcct ttacattttt     1080

aagcagcctt ttatgaggcc agtacagacg actcaagagg aagacgggtg ctcatgccgc     1140

tttcctgagg aggaggaagg agggtgcgaa ctgcgcgtta agttctcccg atcagccgac     1200

gcgcctgctt acaagcaggg ccagaaccaa ctgtacaacg agctgaatct cggtagacgg     1260

gaagagtacg acgtgttgga caaacggaga ggccgcgacc cagaaatggg cggcaagcct     1320

cgcaggaaaa acccccagga gggactgtac aatgagttgc agaaagataa gatggcagaa     1380

gcttatagcg agatcggaat gaagggggaa aggagacgag ggaaaggaca cgacggcctt     1440

tatcagggcc tgtccacagc aacaaaagat acgtatgacg ccctccatat gcaggcactt     1500

ccaccacggt gataa                                                      1515


<210>  755
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD4/CD4/CD28/4-1BB/CD3z sequence CAR38

<400>  755

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Ser Gly Gln Val Leu Leu Glu Ser 
            260                 265                 270         


Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala 
        275                 280                 285             


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
    290                 295                 300                 


Gly Ile Phe Phe Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
305                 310                 315                 320 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
                325                 330                 335     


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly 
            340                 345                 350         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        355                 360                 365             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    370                 375                 380                 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
385                 390                 395                 400 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                405                 410                 415     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            420                 425                 430         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        435                 440                 445             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    450                 455                 460                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
465                 470                 475                 480 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                485                 490                 495     


Met Gln Ala Leu Pro Pro Arg 
            500             


<210>  756
<211>  1500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD4/CD4/CD28/OX40/CD3z sequence

<400>  756
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aatcgggaca ggtcctgctg gaatccaaca tcaaggttct gcccacatgg      840

tccaccccgg tgcagccaat ggccctgatt gtgctggggg gcgtcgccgg cctcctgctt      900

ttcattgggc taggcatctt cttcagaagc aagcggtctc ggctcctgca ttctgattac      960

atgaacatga ccccaagaag accaggcccc accaggaaac attaccagcc ctacgctccg     1020

ccacgcgact tcgctgccta ccggtcccgg agggaccaga ggctgccccc cgatgcccac     1080

aagccccctg ggggaggcag tttccggacc cccatccaag aggagcaggc cgacgcccac     1140

tccaccctgg ccaagatccg cgttaagttc tcccgatcag ccgacgcgcc tgcttacaag     1200

cagggccaga accaactgta caacgagctg aatctcggta gacgggaaga gtacgacgtg     1260

ttggacaaac ggagaggccg cgacccagaa atgggcggca agcctcgcag gaaaaacccc     1320

caggagggac tgtacaatga gttgcagaaa gataagatgg cagaagctta tagcgagatc     1380

ggaatgaagg gggaaaggag acgagggaaa ggacacgacg gcctttatca gggcctgtcc     1440

acagcaacaa aagatacgta tgacgccctc catatgcagg cacttccacc acggtgataa     1500


<210>  757
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 CD4/CD4/CD28/OX40/CD3z sequence

<400>  757

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Ser Gly Gln Val Leu Leu Glu Ser 
            260                 265                 270         


Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala 
        275                 280                 285             


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
    290                 295                 300                 


Gly Ile Phe Phe Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
305                 310                 315                 320 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
                325                 330                 335     


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Arg Asp 
            340                 345                 350         


Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe 
        355                 360                 365             


Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala 
    370                 375                 380                 


Lys Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg 
        


<210>  758
<211>  1284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/CD3z sequence: CAR59

<400>  758
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc tcgggacagg tcctgctgga atccaacatc      840

aaggttctgc ccacatggtc caccccggtg cagccaatgg ccctgattgt gctggggggc      900

gtcgccggcc tcctgctttt cattgggcta ggcatcttct tccgcgttaa gttctcccga      960

tcagccgacg cgcctgctta caagcagggc cagaaccaac tgtacaacga gctgaatctc     1020

ggtagacggg aagagtacga cgtgttggac aaacggagag gccgcgaccc agaaatgggc     1080

ggcaagcctc gcaggaaaaa cccccaggag ggactgtaca atgagttgca gaaagataag     1140

atggcagaag cttatagcga gatcggaatg aagggggaaa ggagacgagg gaaaggacac     1200

gacggccttt atcagggcct gtccacagca acaaaagata cgtatgacgc cctccatatg     1260

caggcacttc caccacggtg ataa                                            1284


<210>  759
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/CD3z sequence: CAR59

<400>  759

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Ser Gly 
            260                 265                 270         


Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr 
        275                 280                 285             


Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
    290                 295                 300                 


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Arg Val Lys Phe Ser Arg 
305                 310                 315                 320 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
                325                 330                 335     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            340                 345                 350         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        355                 360                 365             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    370                 375                 380                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
385                 390                 395                 400 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                405                 410                 415     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425     


<210>  760
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/CD28/CD3z sequence: CAR60

<400>  760
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc tcgggacagg tcctgctgga atccaacatc      840

aaggttctgc ccacatggtc caccccggtg cagccaatgg ccctgattgt gctggggggc      900

gtcgccggcc tcctgctttt cattgggcta ggcatcttct tcagaagcaa gcggtctcgg      960

ctcctgcatt ctgattacat gaacatgacc ccaagaagac caggccccac caggaaacat     1020

taccagccct acgctccgcc acgcgacttc gctgcctacc ggtcccgcgt taagttctcc     1080

cgatcagccg acgcgcctgc ttacaagcag ggccagaacc aactgtacaa cgagctgaat     1140

ctcggtagac gggaagagta cgacgtgttg gacaaacgga gaggccgcga cccagaaatg     1200

ggcggcaagc ctcgcaggaa aaacccccag gagggactgt acaatgagtt gcagaaagat     1260

aagatggcag aagcttatag cgagatcgga atgaaggggg aaaggagacg agggaaagga     1320

cacgacggcc tttatcaggg cctgtccaca gcaacaaaag atacgtatga cgccctccat     1380

atgcaggcac ttccaccacg gtgataa                                         1407


<210>  761
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/CD28/CD3z sequence: CAR60

<400>  761

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Ser Gly 
            260                 265                 270         


Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr 
        275                 280                 285             


Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
    290                 295                 300                 


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        355                 360                 365             


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  762
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/4-1BB/CD3z sequence:CAR61

<400>  762
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc tcgggacagg tcctgctgga atccaacatc      840

aaggttctgc ccacatggtc caccccggtg cagccaatgg ccctgattgt gctggggggc      900

gtcgccggcc tcctgctttt cattgggcta ggcatcttct tcaaaagggg ccgcaaaaaa      960

ctcctttaca tttttaagca gccttttatg aggccagtac agacgactca agaggaagac     1020

gggtgctcat gccgctttcc tgaggaggag gaaggagggt gcgaactgcg cgttaagttc     1080

tcccgatcag ccgacgcgcc tgcttacaag cagggccaga accaactgta caacgagctg     1140

aatctcggta gacgggaaga gtacgacgtg ttggacaaac ggagaggccg cgacccagaa     1200

atgggcggca agcctcgcag gaaaaacccc caggagggac tgtacaatga gttgcagaaa     1260

gataagatgg cagaagctta tagcgagatc ggaatgaagg gggaaaggag acgagggaaa     1320

ggacacgacg gcctttatca gggcctgtcc acagcaacaa aagatacgta tgacgccctc     1380

catatgcagg cacttccacc acggtgataa                                      1410


<210>  763
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/4-1BB/CD3z sequence:CAR61

<400>  763

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Ser Gly 
            260                 265                 270         


Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr 
        275                 280                 285             


Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
    290                 295                 300                 


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Lys Arg Gly Arg Lys Lys 
305                 310                 315                 320 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                325                 330                 335     


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            340                 345                 350         


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                405                 410                 415     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            420                 425                 430         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        435                 440                 445             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    450                 455                 460                 


Leu Pro Pro Arg 
465             


<210>  764
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/OX40/CD3z sequence:

<400>  764
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc tcgggacagg tcctgctgga atccaacatc      840

aaggttctgc ccacatggtc caccccggtg cagccaatgg ccctgattgt gctggggggc      900

gtcgccggcc tcctgctttt cattgggcta ggcatcttct tccggaggga ccagaggctg      960

ccccccgatg cccacaagcc ccctggggga ggcagtttcc ggacccccat ccaagaggag     1020

caggccgacg cccactccac cctggccaag atccgcgtta agttctcccg atcagccgac     1080

gcgcctgctt acaagcaggg ccagaaccaa ctgtacaacg agctgaatct cggtagacgg     1140

gaagagtacg acgtgttgga caaacggaga ggccgcgacc cagaaatggg cggcaagcct     1200

cgcaggaaaa acccccagga gggactgtac aatgagttgc agaaagataa gatggcagaa     1260

gcttatagcg agatcggaat gaagggggaa aggagacgag ggaaaggaca cgacggcctt     1320

tatcagggcc tgtccacagc aacaaaagat acgtatgacg ccctccatat gcaggcactt     1380

ccaccacggt gataa                                                      1395


<210>  765
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/OX40/CD3z sequence

<400>  765

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Ser Gly 
            260                 265                 270         


Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr 
        275                 280                 285             


Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
    290                 295                 300                 


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Arg Arg Asp Gln Arg Leu 
305                 310                 315                 320 


Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro 
                325                 330                 335     


Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg 
            340                 345                 350         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
        355                 360                 365             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    370                 375                 380                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
385                 390                 395                 400 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                405                 410                 415     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            420                 425                 430         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        435                 440                 445             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460             


<210>  766
<211>  1533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/CD28/4-1BB/CD3z sequence: CAR62

<400>  766
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc tcgggacagg tcctgctgga atccaacatc      840

aaggttctgc ccacatggtc caccccggtg cagccaatgg ccctgattgt gctggggggc      900

gtcgccggcc tcctgctttt cattgggcta ggcatcttct tcagaagcaa gcggtctcgg      960

ctcctgcatt ctgattacat gaacatgacc ccaagaagac caggccccac caggaaacat     1020

taccagccct acgctccgcc acgcgacttc gctgcctacc ggtccaaaag gggccgcaaa     1080

aaactccttt acatttttaa gcagcctttt atgaggccag tacagacgac tcaagaggaa     1140

gacgggtgct catgccgctt tcctgaggag gaggaaggag ggtgcgaact gcgcgttaag     1200

ttctcccgat cagccgacgc gcctgcttac aagcagggcc agaaccaact gtacaacgag     1260

ctgaatctcg gtagacggga agagtacgac gtgttggaca aacggagagg ccgcgaccca     1320

gaaatgggcg gcaagcctcg caggaaaaac ccccaggagg gactgtacaa tgagttgcag     1380

aaagataaga tggcagaagc ttatagcgag atcggaatga agggggaaag gagacgaggg     1440

aaaggacacg acggccttta tcagggcctg tccacagcaa caaaagatac gtatgacgcc     1500

ctccatatgc aggcacttcc accacggtga taa                                  1533


<210>  767
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/CD28/4-1BB/CD3z sequence: CAR62

<400>  767

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Ser Gly 
            260                 265                 270         


Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr 
        275                 280                 285             


Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
    290                 295                 300                 


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  768
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/CD28/OX40/CD3z sequence

<400>  768
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc tcgggacagg tcctgctgga atccaacatc      840

aaggttctgc ccacatggtc caccccggtg cagccaatgg ccctgattgt gctggggggc      900

gtcgccggcc tcctgctttt cattgggcta ggcatcttct tcagaagcaa gcggtctcgg      960

ctcctgcatt ctgattacat gaacatgacc ccaagaagac caggccccac caggaaacat     1020

taccagccct acgctccgcc acgcgacttc gctgcctacc ggtcccggag ggaccagagg     1080

ctgccccccg atgcccacaa gccccctggg ggaggcagtt tccggacccc catccaagag     1140

gagcaggccg acgcccactc caccctggcc aagatccgcg ttaagttctc ccgatcagcc     1200

gacgcgcctg cttacaagca gggccagaac caactgtaca acgagctgaa tctcggtaga     1260

cgggaagagt acgacgtgtt ggacaaacgg agaggccgcg acccagaaat gggcggcaag     1320

cctcgcagga aaaaccccca ggagggactg tacaatgagt tgcagaaaga taagatggca     1380

gaagcttata gcgagatcgg aatgaagggg gaaaggagac gagggaaagg acacgacggc     1440

ctttatcagg gcctgtccac agcaacaaaa gatacgtatg acgccctcca tatgcaggca     1500

cttccaccac ggtgataa                                                   1518


<210>  769
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T C2 CD4/CD4/CD28/OX40/CD3z sequence

<400>  769

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Ser Gly 
            260                 265                 270         


Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr 
        275                 280                 285             


Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
    290                 295                 300                 


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
        355                 360                 365             


Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
    370                 375                 380                 


Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg 
            500                 


<210>  770
<211>  2202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 IgD/FC/CD8/4-1BB/CD3z CAR63

<400>  770
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtggcggagg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aagagtctcc aaaggcacag gcctcctcag tgcccactgc acaaccccaa      840

gcagagggca gcctcgccaa ggcaaccaca gccccagcca ccacccgtaa cacaggaaga      900

ggcggcgaag agaagaaaaa ggagaaggag aaagaggaac aagaagagag agagacaaag      960

acaccagagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa     1020

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     1080

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     1140

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1200

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1260

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1320

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1380

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1440

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1500

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1560

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1620

aaccactaca cgcagaagag cctctccctg tctccgggta aaatctacat ctgggcgccc     1680

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1740

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1800

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1860

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1920

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1980

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     2040

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     2100

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     2160

tacgacgccc ttcacatgca ggccctgccc cctcgctgat aa                        2202


<210>  771
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 IgD/FC/CD8/4-1BB/CD3z CAR63

<400>  771

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Glu Ser Pro Lys Ala Gln Ala Ser 
            260                 265                 270         


Ser Val Pro Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala 
        275                 280                 285             


Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu 
    290                 295                 300                 


Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys 
305                 310                 315                 320 


Thr Pro Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                325                 330                 335     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            340                 345                 350         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        355                 360                 365             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    370                 375                 380                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
385                 390                 395                 400 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                405                 410                 415     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            420                 425                 430         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        435                 440                 445             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    450                 455                 460                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
465                 470                 475                 480 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                485                 490                 495     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            500                 505                 510         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        515                 520                 525             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    530                 535                 540                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Tyr Ile Trp Ala Pro 
545                 550                 555                 560 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                565                 570                 575     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            580                 585                 590         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        595                 600                 605             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    610                 615                 620                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
625                 630                 635                 640 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                645                 650                 655     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            660                 665                 670         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        675                 680                 685             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    690                 695                 700                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
705                 710                 715                 720 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730         


<210>  772
<211>  2157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 IgD/FCHingeless Y407R/CD8/4-1BB/CD3z CAR64

<400>  772
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtggcggagg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aagagtctcc aaaggcacag gcctcctcag tgcccactgc acaaccccaa      840

gcagagggca gcctcgccaa ggcaaccaca gccccagcca ccacccgtaa cacaggaaga      900

ggcggcgaag agaagaaaaa ggagaaggag aaagaggaac aagaagagag agagacaaag      960

acaccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag     1020

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac     1080

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1140

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1200

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1260

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1320

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1380

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1440

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctcaggagc     1500

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1560

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaaatc     1620

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1680

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1740

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1800

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     1860

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1920

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1980

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     2040

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     2100

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctgataa        2157


<210>  773
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-T E6 IgD/FCHingeless Y407R/CD8/4-1BB/CD3z CAR64

<400>  773

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Glu Ser Pro Lys Ala Gln Ala Ser 
            260                 265                 270         


Ser Val Pro Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala 
        275                 280                 285             


Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu 
    290                 295                 300                 


Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys 
305                 310                 315                 320 


Thr Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                325                 330                 335     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            340                 345                 350         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        355                 360                 365             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    370                 375                 380                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
385                 390                 395                 400 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                405                 410                 415     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            420                 425                 430         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        435                 440                 445             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    450                 455                 460                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
465                 470                 475                 480 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                485                 490                 495     


Phe Leu Arg Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            500                 505                 510         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        515                 520                 525             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Tyr Ile Trp Ala 
    530                 535                 540                 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
545                 550                 555                 560 


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                565                 570                 575     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            580                 585                 590         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        595                 600                 605             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
    610                 615                 620                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
625                 630                 635                 640 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                645                 650                 655     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            660                 665                 670         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        675                 680                 685             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    690                 695                 700                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
705                 710                 715         


<210>  774
<211>  3829
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1P2-MMP9

<400>  774
caggcctggg gacactcgcg gcgggaagat ttggagggga ggggaggggg aggggcgtgg       60

gggcgcggcc tcgctggagt ccccctgacc ccccgacccc cgcccaccgg cctgggcgtc      120

ctcccgcggc ccctcctccc ctcccggcgc ccggtgctct ggggcgcgtg ccacgcctgg      180

ctcggcgccg taggggcccc cgcaggtaga gacccctgga aatggcctcg acgccgcagg      240

agcgaggcgg ccaccacccc gctaatccgg gcacgtctct ccaggccgag gcctgcggtg      300

gaaaagccgg ggttccattt gtgctgagtc ggggcggccg aatggagcca ggcctcggga      360

cgcgggacgg acgggctctg gccgcgcacc ttcgcgggct ctgcagcgcc cgaccgcctc      420

ccccggcagg gaggaggcgc ttgtgggggg cacccacggg gcacagtgat ccctgggggt      480

ctgcggacct cctgggcccc gcagcagaca cgagtttagc ctttgggttt agtttaaatc      540

acataagggt gtcgtgcaat cgatttatgg tttctacaca ccagacactt taacctccaa      600

ccccccccat ccaaagccaa caagaaaatg cggtgccgtg ttggcagctg agctgcgccc      660

gaagagacgc agggagacgt aagagaggaa agtgtgagtg gccggggggc ctccccccgt      720

cagaagtcgc gcagtcgcgc ccataaaacg ccccctccgg gcggctaggg caggtgagcg      780

cgtccccggg cctccccacg ccggcccctg ccacaggccg tctaggtcga gcagatattt      840

acagaataaa aatgacaata actcgacgtc ccgggacggc cacgcaatct gttagtaatt      900

tagcgggatg ggaatttcct ttctagggcc tgccagtgaa gcgcttttcc aaatttccac      960

agcgggggaa gcctgcgatt ttacataatg acttcagcat gccgggcttt ctcgacaccc     1020

ctccccggcc cccggccccc gccccccgcc ccttttccag cagggccggg ctccctccgg     1080

acacccgcgt ggactcaggc gtcccgtctg gcccgttcgc ccccgtttcc cccgccagcc     1140

ccagcgcccc cctgcccggc ccccggattc cccgttcccg cccctacgcc cccatcccct     1200

ccccgtgcgc ccctccccgt gcgcccccct ccccgtgcgc cccccctccc cgtgcgcccc     1260

cctccccgtg cgccccccct ccccgggcgc ccccctcccc gggcgccccc cctccccgtg     1320

cgcccccccc tccccgtgcg ccccccctcc ccgtgcgcgc cccgcctctt gcgcccctgc     1380

ccccaggcga gcggctgccg cggcgcgggg aggggcgggc gctcggcgac tcgtccccgg     1440

ggccccgcgc gggcccgggc agcaggggcg tgatgtcacg gcagggaggg ggcgcgggag     1500

ccgccgggcc ggcggggagg cgggggaggt gttttccagc tttaaaaagg caggaggcag     1560

agcgcggccc tgcgtcagag cgagactcag aggctccgaa ctcgccggcg gagtcgccgc     1620

gccagatccc agcagcaggg cgcggaagct tctctcgaca ttcgtttcta gagccaccat     1680

gagcctctgg cagcccctgg tcctggtgct cctggtgctg ggctgctgct ttgctgcccc     1740

cagacagcgc cagtccaccc ttgtgctctt ccctggagac ctgagaacca atctcaccga     1800

caggcagctg gcagaggaat acctgtaccg ctatggttac actcgggtgg cagagatgcg     1860

tggagagtcg aaatctctgg ggcctgcgct gctgcttctc cagaagcaac tgtccctgcc     1920

cgagaccggt gagctggata gcgccacgct gaaggccatg cgaaccccac ggtgcggggt     1980

cccagacctg ggcagattcc aaacctttga gggcgacctc aagtggcacc accacaacat     2040

cacctattgg atccaaaact actcggaaga cttgccgcgg gcggtgattg acgacgcctt     2100

tgcccgcgcc ttcgcactgt ggagcgcggt gacgccgctc accttcactc gcgtgtacag     2160

ccgggacgca gacatcgtca tccagtttgg tgtcgcggag cacggagacg ggtatccctt     2220

cgacgggaag gacgggctcc tggcacacgc ctttcctcct ggccccggca ttcagggaga     2280

cgcccatttc gacgatgacg agttgtggtc cctgggcaag ggcgtcgtgg ttccaactcg     2340

gtttggaaac gcagatggcg cggcctgcca cttccccttc atcttcgagg gccgctccta     2400

ctctgcctgc accaccgacg gtcgctccga cggcttgccc tggtgcagta ccacggccaa     2460

ctacgacacc gacgaccggt ttggcttctg ccccagcgag agactctaca cccaggacgg     2520

caatgctgat gggaaaccct gccagtttcc attcatcttc caaggccaat cctactccgc     2580

ctgcaccacg gacggtcgct ccgacggcta ccgctggtgc gccaccaccg ccaactacga     2640

ccgggacaag ctcttcggct tctgcccgac ccgagctgac tcgacggtga tggggggcaa     2700

ctcggcgggg gagctgtgcg tcttcccctt cactttcctg ggtaaggagt actcgacctg     2760

taccagcgag ggccgcggag atgggcgcct ctggtgcgct accacctcga actttgacag     2820

cgacaagaag tggggcttct gcccggacca aggatacagt ttgttcctcg tggcggcgca     2880

tgagttcggc cacgcgctgg gcttagatca ttcctcagtg ccggaggcgc tcatgtaccc     2940

tatgtaccgc ttcactgagg ggcccccctt gcataaggac gacgtgaatg gcatccggca     3000

cctctatggt cctcgccctg aacctgagcc acggcctcca accaccacca caccgcagcc     3060

cacggctccc ccgacggtct gccccaccgg accccccact gtccacccct cagagcgccc     3120

cacagctggc cccacaggtc ccccctcagc tggccccaca ggtcccccca ctgctggccc     3180

ttctacggcc actactgtgc ctttgagtcc ggtggacgat gcctgcaacg tgaacatctt     3240

cgacgccatc gcggagattg ggaaccagct gtatttgttc aaggatggga agtactggcg     3300

attctctgag ggcaggggga gccggccgca gggccccttc cttatcgccg acaagtggcc     3360

cgcgctgccc cgcaagctgg actcggtctt tgaggagcgg ctctccaaga agcttttctt     3420

cttctctggg cgccaggtgt gggtgtacac aggcgcgtcg gtgctgggcc cgaggcgtct     3480

ggacaagctg ggcctgggag ccgacgtggc ccaggtgacc ggggccctcc ggagtggcag     3540

ggggaagatg ctgctgttca gcgggcggcg cctctggagg ttcgacgtga aggcgcagat     3600

ggtggatccc cggagcgcca gcgaggtgga ccggatgttc cccggggtgc ctttggacac     3660

gcacgacgtc ttccagtacc gagagaaagc ctatttctgc caggaccgct tctactggcg     3720

cgtgagttcc cggagtgagt tgaaccaggt ggaccaagtg ggctacgtga cctatgacat     3780

cctgcagtgc cctgaggacg attacaagga tgacgacgat aagtgataa                 3829


<210>  775
<211>  2794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1P2-MMP9cat

<400>  775
caggcctggg gacactcgcg gcgggaagat ttggagggga ggggaggggg aggggcgtgg       60

gggcgcggcc tcgctggagt ccccctgacc ccccgacccc cgcccaccgg cctgggcgtc      120

ctcccgcggc ccctcctccc ctcccggcgc ccggtgctct ggggcgcgtg ccacgcctgg      180

ctcggcgccg taggggcccc cgcaggtaga gacccctgga aatggcctcg acgccgcagg      240

agcgaggcgg ccaccacccc gctaatccgg gcacgtctct ccaggccgag gcctgcggtg      300

gaaaagccgg ggttccattt gtgctgagtc ggggcggccg aatggagcca ggcctcggga      360

cgcgggacgg acgggctctg gccgcgcacc ttcgcgggct ctgcagcgcc cgaccgcctc      420

ccccggcagg gaggaggcgc ttgtgggggg cacccacggg gcacagtgat ccctgggggt      480

ctgcggacct cctgggcccc gcagcagaca cgagtttagc ctttgggttt agtttaaatc      540

acataagggt gtcgtgcaat cgatttatgg tttctacaca ccagacactt taacctccaa      600

ccccccccat ccaaagccaa caagaaaatg cggtgccgtg ttggcagctg agctgcgccc      660

gaagagacgc agggagacgt aagagaggaa agtgtgagtg gccggggggc ctccccccgt      720

cagaagtcgc gcagtcgcgc ccataaaacg ccccctccgg gcggctaggg caggtgagcg      780

cgtccccggg cctccccacg ccggcccctg ccacaggccg tctaggtcga gcagatattt      840

acagaataaa aatgacaata actcgacgtc ccgggacggc cacgcaatct gttagtaatt      900

tagcgggatg ggaatttcct ttctagggcc tgccagtgaa gcgcttttcc aaatttccac      960

agcgggggaa gcctgcgatt ttacataatg acttcagcat gccgggcttt ctcgacaccc     1020

ctccccggcc cccggccccc gccccccgcc ccttttccag cagggccggg ctccctccgg     1080

acacccgcgt ggactcaggc gtcccgtctg gcccgttcgc ccccgtttcc cccgccagcc     1140

ccagcgcccc cctgcccggc ccccggattc cccgttcccg cccctacgcc cccatcccct     1200

ccccgtgcgc ccctccccgt gcgcccccct ccccgtgcgc cccccctccc cgtgcgcccc     1260

cctccccgtg cgccccccct ccccgggcgc ccccctcccc gggcgccccc cctccccgtg     1320

cgcccccccc tccccgtgcg ccccccctcc ccgtgcgcgc cccgcctctt gcgcccctgc     1380

ccccaggcga gcggctgccg cggcgcgggg aggggcgggc gctcggcgac tcgtccccgg     1440

ggccccgcgc gggcccgggc agcaggggcg tgatgtcacg gcagggaggg ggcgcgggag     1500

ccgccgggcc ggcggggagg cgggggaggt gttttccagc tttaaaaagg caggaggcag     1560

agcgcggccc tgcgtcagag cgagactcag aggctccgaa ctcgccggcg gagtcgccgc     1620

gccagatccc agcagcaggg cgcggaagct tctctcgaca ttcgtttcta gagccaccat     1680

gagcctctgg cagcccctgg tcctggtgct cctggtgctg ggctgctgct ttgctttcca     1740

aacctttgag ggcgacctca agtggcacca ccacaacatc acctattgga tccaaaacta     1800

ctcggaagac ttgccgcggg cggtgattga cgacgccttt gcccgcgcct tcgcactgtg     1860

gagcgcggtg acgccgctca ccttcactcg cgtgtacagc cgggacgcag acatcgtcat     1920

ccagtttggt gtcgcggagc acggagacgg gtatcccttc gacgggaagg acgggctcct     1980

ggcacacgcc tttcctcctg gccccggcat tcagggagac gcccatttcg acgatgacga     2040

gttgtggtcc ctgggcaagg gcgtcgtggt tccaactcgg tttggaaacg cagatggcgc     2100

ggcctgccac ttccccttca tcttcgaggg ccgctcctac tctgcctgca ccaccgacgg     2160

tcgctccgac ggcttgccct ggtgcagtac cacggccaac tacgacaccg acgaccggtt     2220

tggcttctgc cccagcgaga gactctacac ccaggacggc aatgctgatg ggaaaccctg     2280

ccagtttcca ttcatcttcc aaggccaatc ctactccgcc tgcaccacgg acggtcgctc     2340

cgacggctac cgctggtgcg ccaccaccgc caactacgac cgggacaagc tcttcggctt     2400

ctgcccgacc cgagctgact cgacggtgat ggggggcaac tcggcggggg agctgtgcgt     2460

cttccccttc actttcctgg gtaaggagta ctcgacctgt accagcgagg gccgcggaga     2520

tgggcgcctc tggtgcgcta ccacctcgaa ctttgacagc gacaagaagt ggggcttctg     2580

cccggaccaa ggatacagtt tgttcctcgt ggcggcgcat gagttcggcc acgcgctggg     2640

cttagatcat tcctcagtgc cggaggcgct catgtaccct atgtaccgct tcactgaggg     2700

gccccccttg cataaggacg acgtgaatgg catccggcac ctctatggtc ctcgccctga     2760

acctgattac aaggatgacg acgataagtg ataa                                 2794


<210>  776
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT response element 2

<400>  776
aagaggaaaa tttgtttcat acagaaggcg tt                                     32


<210>  777
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT response element 2 repeats

<400>  777
aagaggaaaa tttgtttcat acagaaggcg ttaagaggaa aatttgtttc atacagaagg       60

cgttaagagg aaaatttgtt tcatacagaa ggcgttaaga ggaaaatttg tttcatacag      120

aaggcgtt                                                               128


<210>  778
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV minimal promoter 2

<400>  778
taggcgtgta cggtgggagg cctatataag cagagctcgt ttagtgaacc gtcagatcgc       60

ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc gatccagc        118


<210>  779
<211>  2430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATRE2mCMV2-MMP9

<400>  779
aagaggaaaa tttgtttcat acagaaggcg ttaagaggaa aatttgtttc atacagaagg       60

cgttaagagg aaaatttgtt tcatacagaa ggcgttaaga ggaaaatttg tttcatacag      120

aaggcgttac tagttaggcg tgtacggtgg gaggcctata taagcagagc tcgtttagtg      180

aaccgtcaga tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg      240

gaccgatcca gcctctcgac attcgtttct agagccacca tgagcctctg gcagcccctg      300

gtcctggtgc tcctggtgct gggctgctgc tttgctgccc ccagacagcg ccagtccacc      360

cttgtgctct tccctggaga cctgagaacc aatctcaccg acaggcagct ggcagaggaa      420

tacctgtacc gctatggtta cactcgggtg gcagagatgc gtggagagtc gaaatctctg      480

gggcctgcgc tgctgcttct ccagaagcaa ctgtccctgc ccgagaccgg tgagctggat      540

agcgccacgc tgaaggccat gcgaacccca cggtgcgggg tcccagacct gggcagattc      600

caaacctttg agggcgacct caagtggcac caccacaaca tcacctattg gatccaaaac      660

tactcggaag acttgccgcg ggcggtgatt gacgacgcct ttgcccgcgc cttcgcactg      720

tggagcgcgg tgacgccgct caccttcact cgcgtgtaca gccgggacgc agacatcgtc      780

atccagtttg gtgtcgcgga gcacggagac gggtatccct tcgacgggaa ggacgggctc      840

ctggcacacg cctttcctcc tggccccggc attcagggag acgcccattt cgacgatgac      900

gagttgtggt ccctgggcaa gggcgtcgtg gttccaactc ggtttggaaa cgcagatggc      960

gcggcctgcc acttcccctt catcttcgag ggccgctcct actctgcctg caccaccgac     1020

ggtcgctccg acggcttgcc ctggtgcagt accacggcca actacgacac cgacgaccgg     1080

tttggcttct gccccagcga gagactctac acccaggacg gcaatgctga tgggaaaccc     1140

tgccagtttc cattcatctt ccaaggccaa tcctactccg cctgcaccac ggacggtcgc     1200

tccgacggct accgctggtg cgccaccacc gccaactacg accgggacaa gctcttcggc     1260

ttctgcccga cccgagctga ctcgacggtg atggggggca actcggcggg ggagctgtgc     1320

gtcttcccct tcactttcct gggtaaggag tactcgacct gtaccagcga gggccgcgga     1380

gatgggcgcc tctggtgcgc taccacctcg aactttgaca gcgacaagaa gtggggcttc     1440

tgcccggacc aaggatacag tttgttcctc gtggcggcgc atgagttcgg ccacgcgctg     1500

ggcttagatc attcctcagt gccggaggcg ctcatgtacc ctatgtaccg cttcactgag     1560

gggcccccct tgcataagga cgacgtgaat ggcatccggc acctctatgg tcctcgccct     1620

gaacctgagc cacggcctcc aaccaccacc acaccgcagc ccacggctcc cccgacggtc     1680

tgccccaccg gaccccccac tgtccacccc tcagagcgcc ccacagctgg ccccacaggt     1740

cccccctcag ctggccccac aggtcccccc actgctggcc cttctacggc cactactgtg     1800

cctttgagtc cggtggacga tgcctgcaac gtgaacatct tcgacgccat cgcggagatt     1860

gggaaccagc tgtatttgtt caaggatggg aagtactggc gattctctga gggcaggggg     1920

agccggccgc agggcccctt ccttatcgcc gacaagtggc ccgcgctgcc ccgcaagctg     1980

gactcggtct ttgaggagcg gctctccaag aagcttttct tcttctctgg gcgccaggtg     2040

tgggtgtaca caggcgcgtc ggtgctgggc ccgaggcgtc tggacaagct gggcctggga     2100

gccgacgtgg cccaggtgac cggggccctc cggagtggca gggggaagat gctgctgttc     2160

agcgggcggc gcctctggag gttcgacgtg aaggcgcaga tggtggatcc ccggagcgcc     2220

agcgaggtgg accggatgtt ccccggggtg cctttggaca cgcacgacgt cttccagtac     2280

cgagagaaag cctatttctg ccaggaccgc ttctactggc gcgtgagttc ccggagtgag     2340

ttgaaccagg tggaccaagt gggctacgtg acctatgaca tcctgcagtg ccctgaggac     2400

gattacaagg atgacgacga taagtgataa                                      2430


<210>  780
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATRE2mCMV2-MMP9cat

<400>  780
aagaggaaaa tttgtttcat acagaaggcg ttaagaggaa aatttgtttc atacagaagg       60

cgttaagagg aaaatttgtt tcatacagaa ggcgttaaga ggaaaatttg tttcatacag      120

aaggcgttac tagttaggcg tgtacggtgg gaggcctata taagcagagc tcgtttagtg      180

aaccgtcaga tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg      240

gaccgatcca gcctcgagct ctcgacattc gtttctagag ccaccatgag cctctggcag      300

cccctggtcc tggtgctcct ggtgctgggc tgctgctttg ctttccaaac ctttgagggc      360

gacctcaagt ggcaccacca caacatcacc tattggatcc aaaactactc ggaagacttg      420

ccgcgggcgg tgattgacga cgcctttgcc cgcgccttcg cactgtggag cgcggtgacg      480

ccgctcacct tcactcgcgt gtacagccgg gacgcagaca tcgtcatcca gtttggtgtc      540

gcggagcacg gagacgggta tcccttcgac gggaaggacg ggctcctggc acacgccttt      600

cctcctggcc ccggcattca gggagacgcc catttcgacg atgacgagtt gtggtccctg      660

ggcaagggcg tcgtggttcc aactcggttt ggaaacgcag atggcgcggc ctgccacttc      720

cccttcatct tcgagggccg ctcctactct gcctgcacca ccgacggtcg ctccgacggc      780

ttgccctggt gcagtaccac ggccaactac gacaccgacg accggtttgg cttctgcccc      840

agcgagagac tctacaccca ggacggcaat gctgatggga aaccctgcca gtttccattc      900

atcttccaag gccaatccta ctccgcctgc accacggacg gtcgctccga cggctaccgc      960

tggtgcgcca ccaccgccaa ctacgaccgg gacaagctct tcggcttctg cccgacccga     1020

gctgactcga cggtgatggg gggcaactcg gcgggggagc tgtgcgtctt ccccttcact     1080

ttcctgggta aggagtactc gacctgtacc agcgagggcc gcggagatgg gcgcctctgg     1140

tgcgctacca cctcgaactt tgacagcgac aagaagtggg gcttctgccc ggaccaagga     1200

tacagtttgt tcctcgtggc ggcgcatgag ttcggccacg cgctgggctt agatcattcc     1260

tcagtgccgg aggcgctcat gtaccctatg taccgcttca ctgaggggcc ccccttgcat     1320

aaggacgacg tgaatggcat ccggcacctc tatggtcctc gccctgaacc tgattacaag     1380

gatgacgacg ataagtgata a                                               1401


<210>  781
<211>  2238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 Promoter fragment (P1)

<400>  781
aggcaggagg aagaggaaag gggcgcaggg cgctcgggga gcagagccgg gggcccgcgg       60

tggccgcaga ggccgggccg gggcgcagag gccgggcgag ctggccgcgc tctgggccgc      120

cgcctccgga actccctgcg cctggcgcgc ggccaccgtg gtcccggcaa cggcattaaa      180

cagagggaaa cagacccggg attccgtcac ccgggcgggg ggataaggac ggctttgaga      240

gcagacagga aaagggagct tttctgcatg gggtgaaaaa attatttatt gaaggaggag      300

gaggcggcag cggaggaagg ggaggggcgg gaggaggagg aagagccggc cgcccccgcc      360

ccggccccgg ctcctcagga gccaagggca gcctcgccag gtcggtcccg ggctcgagga      420

ccgcggctgg ggtcgagggg ctcagtctcc cacgtgaccg gctgggcgcg ccccgccaga      480

cccggcctcg ggattccctc ctcccggcga gtctccgccc gccccgtcct ggaggtgggg      540

agaaggaggg cggggcgggg gggacggaaa ctctccccgc caaatcctgg ccccaggcct      600

ggggacactc gcggcgggaa gatttggagg ggaggggagg gggaggggcg tgggggcgcg      660

gcctcgctgg agtccccctg accccccgac ccccgcccac cggcctgggc gtcctcccgc      720

ggcccctcct cccctcccgg cgcccggtgc tctggggcgc gtgccacgcc tggctcggcg      780

ccgtaggggc ccccgcaggt agagacccct ggaaatggcc tcgacgccgc aggagcgagg      840

cggccaccac cccgctaatc cgggcacgtc tctccaggcc gaggcctgcg gtggaaaagc      900

cggggttcca tttgtgctga gtcggggcgg ccgaatggag ccaggcctcg ggacgcggga      960

cggacgggct ctggccgcgc accttcgcgg gctctgcagc gcccgaccgc ctcccccggc     1020

agggaggagg cgcttgtggg gggcacccac ggggcacagt gatccctggg ggtctgcgga     1080

cctcctgggc cccgcagcag acacgagttt agcctttggg tttagtttaa atcacataag     1140

ggtgtcgtgc aatcgattta tggtttctac acaccagaca ctttaacctc caaccccccc     1200

catccaagcc aacaagaaaa tgcggtgccg tgttggcagc tgagctgcgc ccgaagagac     1260

gcagggagac gtaagagagg aaagtgtgag tggccggggg gcctcccccc gtcagaagtc     1320

gcgcagtcgc gcccataaaa cgccccctcc gggcggctag ggcaggtgag cgcgtccccg     1380

ggcctcccca cgccggcccc tgccacagag ccgtctaggt cgagcagata tttacagaat     1440

aaaaatgaca ataactcgac gtcccgggac ggccacgcaa tctgttagta atttagcggg     1500

atgggaattt cctttctagg gcctgccagt gaagcgcttt tccaaatttc cacagcgggg     1560

gaagcctgcg attttacata atgacttcag catgccgggc tttctcgaca cccctccccg     1620

gcccccggcc cccgcccccc gccccttttc cagcagggcc gggctccctc cggacacccg     1680

cgtggactca ggcgtcccgt ctggcccgtt cgcccccgtt tcccccgcca gccccagcgc     1740

ccccctgccc ggcccccgga ttccccgttc ccgcccctac gcccccatcc cctccccgtg     1800

cgcccctccc cgtgcgcccc cctccccgtg cgccccccct ccccgtgcgc ccccctcccc     1860

gtgcgccccc cctccccggg cgcccccctc cccgggcgcc ccccctcccc gtgcgccccc     1920

ccctccccgt gcgccccccc tccccgtgcg cgccccgcct cttgcgcccc tgcccccagg     1980

cgagcggctg ccgcggcgcg gggaggggcg ggcgctcggc gactcgtccc cggggccccg     2040

cgcgggcccg ggcagcaggg gcgtgatgtc acggcaggga gggggcgcgg gagccgccgg     2100

gccggcgggg aggcggggga ggtgttttcc agctttaaaa aggcaggagg cagagcgcgg     2160

ccctgcgtca gagcgagact cagaggctcc gaactcgccg gcggagtcgc cgcgccagat     2220

cccagcagca gggcgcgg                                                   2238


<210>  782
<211>  2186
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 Promoter fragment (P2)

<400>  782
aggcaggagg aagaggaaag gggcgcaggg cgctcgggga gcagagccgg gggcccgcgg       60

tggccgcaga ggccgggccg gggcgcagag gccgggcgag ctggccgcgc tctgggccgc      120

cgcctccgga actccctgcg cctggcgcgc ggccaccgtg gtcccggcaa cggcattaaa      180

cagagggaaa cagacccggg attccgtcac ccgggcgggg ggataaggac ggctttgaga      240

gcagacagga aaagggagct tttctgcatg gggtgaaaaa attatttatt gaaggaggag      300

gaggcggcag cggaggaagg ggaggggcgg gaggaggagg aagagccggc cgcccccgcc      360

ccggccccgg ctcctcagga gccaagggca gcctcgccag gtcggtcccg ggctcgagga      420

ccgcggctgg ggtcgagggg ctcagtctcc cacgtgaccg gctgggcgcg ccccgccaga      480

cccggcctcg ggattccctc ctcccggcga gtctccgccc gccccgtcct ggaggtgggg      540

agaaggaggg cggggcgggg gggacggaaa ctctccccgc caaatcctgg ccccaggcct      600

ggggacactc gcggcgggaa gatttggagg ggaggggagg gggaggggcg tgggggcgcg      660

gcctcgctgg agtccccctg accccccgac ccccgcccac cggcctgggc gtcctcccgc      720

ggcccctcct cccctcccgg cgcccggtgc tctggggcgc gtgccacgcc tggctcggcg      780

ccgtaggggc ccccgcaggt agagacccct ggaaatggcc tcgacgccgc aggagcgagg      840

cggccaccac cccgctaatc cgggcacgtc tctccaggcc gaggcctgcg gtggaaaagc      900

cggggttcca tttgtgctga gtcggggcgg ccgaatggag ccaggcctcg ggacgcggga      960

cggacgggct ctggccgcgc accttcgcgg gctctgcagc gcccgaccgc ctcccccggc     1020

agggaggagg cgcttgtggg gggcacccac ggggcacagt gatccctggg ggtctgcgga     1080

cctcctgggc cccgcagcag acacgagttt agcctttggg tttagtttaa atcacataag     1140

ggtgtcgtgc aatcgattta tggtttctac acaccagaca ctttaacctc caaccccccc     1200

catccaagcc aacaagaaaa tgcggtgccg tgttggcagc tgagctgcgc ccgaagagac     1260

gcagggagac gtaagagagg aaagtgtgag tggccggggg gcctcccccc gtcagaagtc     1320

gcgcagtcgc gcccataaaa cgccccctcc gggcggctag ggcaggtgag cgcgtccccg     1380

ggcctcccca cgccggcccc tgccacagag ccgtctaggt cgagcagata tttacagaat     1440

aaaaatgaca ataactcgac gtcccgggac ggccacgcaa tctgttagta atttagcggg     1500

atgggaattt cctttctagg gcctgccagt gaagcgcttt tccaaatttc cacagcgggg     1560

gaagcctgcg attttacata atgacttcag catgccgggc tttctcgaca cccctccccg     1620

gcccccggcc cccgcccccc gccccttttc cagcagggcc gggctccctc cggacacccg     1680

cgtggactca ggcgtcccgt ctggcccgtt cgcccccgtt tcccccgcca gccccagcgc     1740

ccccctgccc ggcccccgga ttccccgttc ccgcccctac gcccccatcc cctccccgtg     1800

cgcccctccc cgtgcgcccc cctccccgtg cgccccccct ccccgtgcgc ccccctcccc     1860

gtgcgccccc cctccccggg cgcccccctc cccgggcgcc ccccctcccc gtgcgccccc     1920

ccctccccgt gcgccccccc tccccgtgcg cgccccgcct cttgcgcccc tgcccccagg     1980

cgagcggctg ccgcggcgcg gggaggggcg ggcgctcggc gactcgtccc cggggccccg     2040

cgcgggcccg ggcagcaggg gcgtgatgtc acggcaggga gggggcgcgg gagccgccgg     2100

gccggcgggg aggcggggga ggtgttttcc agctttaaaa aggcaggagg cagagcgcgg     2160

ccctgcgtca gagcgagact cagagg                                          2186


<210>  783
<211>  1645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 Promoter fragment (P3)

<400>  783
caggcctggg gacactcgcg gcgggaagat ttggagggga ggggaggggg aggggcgtgg       60

gggcgcggcc tcgctggagt ccccctgacc ccccgacccc cgcccaccgg cctgggcgtc      120

ctcccgcggc ccctcctccc ctcccggcgc ccggtgctct ggggcgcgtg ccacgcctgg      180

ctcggcgccg taggggcccc cgcaggtaga gacccctgga aatggcctcg acgccgcagg      240

agcgaggcgg ccaccacccc gctaatccgg gcacgtctct ccaggccgag gcctgcggtg      300

gaaaagccgg ggttccattt gtgctgagtc ggggcggccg aatggagcca ggcctcggga      360

cgcgggacgg acgggctctg gccgcgcacc ttcgcgggct ctgcagcgcc cgaccgcctc      420

ccccggcagg gaggaggcgc ttgtgggggg cacccacggg gcacagtgat ccctgggggt      480

ctgcggacct cctgggcccc gcagcagaca cgagtttagc ctttgggttt agtttaaatc      540

acataagggt gtcgtgcaat cgatttatgg tttctacaca ccagacactt taacctccaa      600

ccccccccat ccaaagccaa caagaaaatg cggtgccgtg ttggcagctg agctgcgccc      660

gaagagacgc agggagacgt aagagaggaa agtgtgagtg gccggggggc ctccccccgt      720

cagaagtcgc gcagtcgcgc ccataaaacg ccccctccgg gcggctaggg caggtgagcg      780

cgtccccggg cctccccacg ccggcccctg ccacaggccg tctaggtcga gcagatattt      840

acagaataaa aatgacaata actcgacgtc ccgggacggc cacgcaatct gttagtaatt      900

tagcgggatg ggaatttcct ttctagggcc tgccagtgaa gcgcttttcc aaatttccac      960

agcgggggaa gcctgcgatt ttacataatg acttcagcat gccgggcttt ctcgacaccc     1020

ctccccggcc cccggccccc gccccccgcc ccttttccag cagggccggg ctccctccgg     1080

acacccgcgt ggactcaggc gtcccgtctg gcccgttcgc ccccgtttcc cccgccagcc     1140

ccagcgcccc cctgcccggc ccccggattc cccgttcccg cccctacgcc cccatcccct     1200

ccccgtgcgc ccctccccgt gcgcccccct ccccgtgcgc cccccctccc cgtgcgcccc     1260

cctccccgtg cgccccccct ccccgggcgc ccccctcccc gggcgccccc cctccccgtg     1320

cgcccccccc tccccgtgcg ccccccctcc ccgtgcgcgc cccgcctctt gcgcccctgc     1380

ccccaggcga gcggctgccg cggcgcgggg aggggcgggc gctcggcgac tcgtccccgg     1440

ggccccgcgc gggcccgggc agcaggggcg tgatgtcacg gcagggaggg ggcgcgggag     1500

ccgccgggcc ggcggggagg cgggggaggt gttttccagc tttaaaaagg caggaggcag     1560

agcgcggccc tgcgtcagag cgagactcag aggctccgaa ctcgccggcg gagtcgccgc     1620

gccagatccc agcagcaggg cgcgg                                           1645


<210>  784
<211>  927
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pNFAT-MMP9cat-1 gBLOCK sequence

<400>  784
aagaggaaaa tttgtttcat acagaaggcg ttactagtta ggcgtgtacg gtgggaggcc       60

tatataagca gagctcgttt agtgaaccgt cagatcgcct ggagacgcca tccacgctgt      120

tttgacctcc atagaagaca ccgggaccga tccagcctct cgacattcgt ttctagagcc      180

accatgagcc tctggcagcc cctggtcctg gtgctcctgg tgctgggctg ctgctttgct      240

ttccaaacct ttgagggcga cctcaagtgg caccaccaca acatcaccta ttggatccaa      300

aactactcgg aagacttgcc gcgggcggtg attgacgacg cctttgcccg cgccttcgca      360

ctgtggagcg cggtgacgcc gctcaccttc actcgcgtgt acagccggga cgcagacatc      420

gtcatccagt ttggtgtcgc ggagcacgga gacgggtatc ccttcgacgg gaaggacggg      480

ctcctggcac acgcctttcc tcctggcccc ggcattcagg gagacgccca tttcgacgat      540

gacgagttgt ggtccctggg caagggcgtc gtggttccaa ctcggtttgg aaacgcagat      600

ggcgcggcct gccacttccc cttcatcttc gagggccgct cctactctgc ctgcaccacc      660

gacggtcgct ccgacggctt gccctggtgc agtaccacgg ccaactacga caccgacgac      720

cggtttggct tctgccccag cgagagactc tacacccagg acggcaatgc tgatgggaaa      780

ccctgccagt ttccattcat cttccaaggc caatcctact ccgcctgcac cacggacggt      840

cgctccgacg gctaccgctg gtgcgccacc accgccaact acgaccggga caagctcttc      900

ggcttctgcc cgacccgagc tgactcg                                          927


<210>  785
<211>  1064
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pNFAT-MMP9cat-2 gBLOCK sequence

<400>  785
ttcggcttct gcccgacccg agctgactcg acggtgatgg ggggcaactc ggcgggggag       60

ctgtgcgtct tccccttcac tttcctgggt aaggagtact cgacctgtac cagcgagggc      120

cgcggagatg ggcgcctctg gtgcgctacc acctcgaact ttgacagcga caagaagtgg      180

ggcttctgcc cggaccaagg atacagtttg ttcctcgtgg cggcgcatga gttcggccac      240

gcgctgggct tagatcattc ctcagtgccg gaggcgctca tgtaccctat gtaccgcttc      300

actgaggggc cccccttgca taaggacgac gtgaatggca tccggcacct ctatggtcct      360

cgccctgaac ctgattacaa ggatgacgac gataagtgat aagctagctc gactcgacaa      420

tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc      480

ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat      540

ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg      600

gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg      660

ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat      720

tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt      780

gggcactgac aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc      840

ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa      900

tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc cgcatcttcg      960

ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcctg gaattaattc     1020

gagctcggta cctttaagac caatgactta caaggcagct gtag                      1064


<210>  786
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  786
tagatggtac caagaggaaa atttgtttca tacag                                  35


<210>  787
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  787
tagataagct tgctggatcg gtcccggtgt c                                      31


<210>  788
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  788
tcatacagaa ggcgttacta gttaggcgtg tacggtgg                               38


<210>  789
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  789
acagtaccgg attgccaagc ttttatcact tatcgtcgtc atccttg                     47


<210>  790
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  790
aagttggtac cgttccaaac ctttgagggc gacc                                   34


<210>  791
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  791
aagttctcga gcaggttcag ggcgaggacc atag                                   34


<210>  792
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  792
attgactcga gctctcgaca ttcgtttcta gagc                                   34


<210>  793
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  793
attgaaagct tttatcactt atcgtcgtca tccttg                                 36


<210>  794
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  794
tagcaaaata ggctgtccc                                                    19


<210>  795
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  795
attgactcga ggctggatcg gtcccggtgt c                                      31


<210>  796
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  796
aagacaccgg gaccgatcca gcctcgagag acccaagctg gctagccacc                  50


<210>  797
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  797
ttaccaacag taccggattg ccaagctttt atcacttatc gtcgtcatcc                  50


<210>  798
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  798
attgaaagct tctctcgaca ttcgtttcta gagc                                   34


<210>  799
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  799
attgagagct cttatcactt atcgtcgtca tc                                     32


<210>  800
<211>  736
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT modif 1 gBLOCK sequence

<400>  800
attctgtgga taaccgtatt accgctagca tggatctcgg ggacgtctaa ctactaagcg       60

agagtaggga actgccaggc atcaaataaa acgaaaggct cagtcggaag actgggcctt      120

tcgttttatc tgttgtttgt cggtgaacgc tctcctgagt aggacaaatc cgccgggagc      180

ggatttgaac gttgtgaagc aacggcccgg agggtggcgg gcaggacgcc cgccataaac      240

tgccaggcat caaactaagc agaaggccat cctgacggat ggcctttttg cgtttctaca      300

aactcttcct gttagttagt tacttaagct cgggccccaa attatgattt tgttctgact      360

gatagtgacc tgttcgttgc aacaaattga taagcaatgc ttttttataa tgccaacttt      420

gtacaaaaaa gcaggcttcg ctgtgccttc tagttgccag ccatctgttg tttgcccctc      480

ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga      540

ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca      600

ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc      660

tatggttcga aggagataga accagatctt gactagtggt accgaattcc aggcctgggg      720

acactcgcgg cgggaa                                                      736


<210>  801
<211>  802
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT modif 2 gBLOCK sequences

<400>  801
acaaggatga cgacgataag tgataagagc tcgctagcga tatcgccacc atgggggtaa       60

aagttctttt cgcgcttatc tgtatcgcgg ttgcagaagc taaaccaaca gaaaataatg      120

aagactttaa cattgttgcc gtggcatcga acttcgccac aaccgatttg gacgctgatc      180

gcgggaaact gcccggcagc caccacggct cgcaaagctc ggtttgcccg gacttgcacc      240

gttgtgggcg cgggcaagcg catcgtgagc agcgtcgctt gcagcaccgt gggcgcggcc      300

agcaattacg cgaccacgga agccgttgtt aaccacgcga agtagcacgt caagaagctg      360

ccgctggagg tgctcaaaga gctggaagcc aatgcccgga aagctggctg caccaggggc      420

tgtctgatct gcctgtccca catcaagtgc acgcccaaga tgaagaagtt catcccagga      480

cgctgccaca cctacgaagg cgacaaagag tccgcacagg gcggcatagg cgaggcgatc      540

gtcgacattc ctgagattcc tgggttcaag gacttggagc ccctggagca gttcatcgca      600

caggtcgatc tgtgtgtgga ctgcacaact ggctgcctca aagggcttgc caacgtgcag      660

tgttctgacc tgctcaagaa gtggctgccg caacgctgtg cgacctttgc cagcaagatc      720

cagggccagg tggacaagat caagggggcc ggtggtgact aagcggccgc tcgagcatgc      780

atctagaaat aattcttact gt                                               802


<210>  802
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  802
acaaaattca aaattttatc gatactagtt ggcctaactg gccggtacca ag               52


<210>  803
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  803
atccgattta aattcgaatt cgctagctta tcacttatcg tcgtcatcc                   49


<210>  804
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT consensus sequence


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is a, c, g, or t

<400>  804
atggaaaana tcn                                                          13


<210>  805
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Current NFAT RE (Form System Biosciences. The sequence is from 
       the mouse IL2 promoter

<400>  805
aagaggaaaa tttgtttcat acagaaggcg tt                                     32


<210>  806
<211>  812
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse IL2 Promoter (highlighted in green the NFAT RE used, 
       highlighted in yellow is the start codon)

<400>  806
aactagagac atataaaata acaccaacat ccttagatac aacccttcct gagaatttat       60

tggacatcat actcttttta aaaagcataa taaacatcaa gacacttaca caaaatatgt      120

taaattaaat ttaaaacaac aacgacaaaa tagtacctca agctcaacaa gcattttagg      180

tgtccttagc ttactatttc tctggctaac tgtatgaagc catctatcac cctgtgtgca      240

attagctcat tgtgtagata agaaggtaaa accatcttga aacaggaaac caatatcctt      300

cctgtctaat caacaaatct aaaagattta ttcttttcat ctatctcctc ttgcgtttgt      360

ccaccacaac aggctgctta caggttcagg atggttttga caaagagaac attttcatga      420

gttacttttg tgtctccacc ccaaagagga aaatttgttt catacagaag gcgttcattg      480

tatgaattaa aactgccacc taagtgtggg ctaacccgac caagagggat ttcacctaaa      540

tccattcagt cagtgtatgg gggtttaaag aaattccaga gagtcatcag aagaggaaaa      600

acaaaaggta atgctttctg ccacacaggt agactctttg aaaatatgtg taatatgtaa      660

aacatcgtga cacccccata ttatttttcc agcattaaca gtataaattg cctcccatgc      720

tgaagagctg cctatcaccc ttgctaatca ctcctcacag tgacctcaag tcctgcaggc      780

atgtacagca tgcagctcgc atcctgtgtc ac                                    812


<210>  807
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT RE (Form PRomega. The sequence is from the humane IL2 
       promoter

<400>  807
ggaggaaaaa ctgtttcata cagaaggcgt                                        30


<210>  808
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from ET-1 promoter

<400>  808
tccagggaaa atcggagtag aacaagaggg atg                                    33


<210>  809
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from ET-1 promoter

<400>  809
actgttggaa aacgtaaaca cgttattaaa cggt                                   34


<210>  810
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from human CD3?

<400>  810
tccttaacgg aaaaacaaaa                                                   20


<210>  811
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from human CD3?

<400>  811
aaaggaaaaa gtatatgttc                                                   20


<210>  812
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from human IL3 promoter

<400>  812
atgccatgga aagggtg                                                      17


<210>  813
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from human GPC6

<400>  813
aaggggaaat gttgagtcta ga                                                22


<210>  814
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from human growth hormone-releasing hormone

<400>  814
aacttggaaa agcatag                                                      17


<210>  815
<211>  5320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 promoter large

<400>  815
ttatgccgtc tagaggagac atactttcta ctcaaagcta cacacataga ctacaacgat       60

gggaaaagac gacacaccaa cagcgacttc aggaaagctg gagtggctgc taatgttaga      120

caaaataggc tttttaaaaa aggttttatt aaagaggaat gtttcgtaat gataaaagca      180

ctaatctgtg agaaagatac aacaatgata aacatacgtg cagctaataa gagagctcca      240

aaatctatga agcaaaaact cacagaatga ggggagaagc agttctacaa cagagaatgg      300

ggacttcgat actccacttt caataatgga tacaacaacc aggcagataa caaggcaaca      360

gaaggcctga acaacagtat aaaccaatta gacctaccag atatctatag ctagcacact      420

ccacccaacg acagcagaat acacattctt ctcaagcgca caagtaacat cctccaggat      480

gggccatgtt ctaggccatc aaacaaactc aggtggtttg aggccagagg cctctctttt      540

aaccaccaca ctagggcctt cggaggaggc aagcagagag ttgtcaaaga ggccctcagg      600

actgggtgca gtggctcatg actgtaatcc cagcacttta gaaggctgag gcacaaggat      660

cttttgagct caggagttca agaaatgagc acttatccac tgggcgcggt ggctcacgcc      720

agtaatccag cactttggga ggcttaggcg ggcggatcaa gaggtcagaa gctcaagacc      780

agcctgacca acatggtgaa accccgtctc tactaaaagt acaaaaatta gccgggcgtg      840

gtggcgcaca cctgtaatcc cagctacttg ggaggctgag gcaggagaat cacttgaacc      900

cgggaggtgg aggttgcagt gagtggagat cacaccattg caccccagcc tgggcaacag      960

agcgagactc cgtctcaaaa aaaaaaaaaa aaaaaaagaa agaaagaaaa agaaaaaaaa     1020

agtgagcatg tattttgcca gagtctggag attagaatta aattagcaaa ccagaattat     1080

agaaaaagct atttactttt aagtaaacag ctgagatttt tttttttaag tcagtgtgaa     1140

tgaagctcac agccatggtt ggagctgaga aagaaggatt tccctttagt tatgcacctg     1200

tgtcagcacc ttctgacttt ccttctaaag tctggggtgt tcctgaggat ccgtaagttt     1260

ggggttcagg gtttctacag catgctgtta cttgtgaaac atctctttaa ccatgtccca     1320

gagttgccca ggagtttaag accagcctga gcaacatagc aagacctcat ctcaacaaca     1380

acaaaaatta gaaataaatt agccaggtgt ggtgacatgt gcctgtagtc ccagctactc     1440

agaaggctga ggcatgagga tcacttgggc ccaggaagtt ggggctgcag ggagccctgt     1500

tcatgccgct gcactccagc ctgcaagaca gagcagaaaa aaagaatcag gatcctgggc     1560

agagggagga gaggggaccg gggtccagca agcacttggg gattgactga atggcgttgg     1620

ggagagatga ctccaaagtc ctggagtggg tgagaatgac tgcgagtggc ttttaggtgg     1680

ggaggttcct gcctggccac tccgggaggg gacgtggggc tgaagggtat caggtgccgt     1740

gctgagcagt ttggccttga tcctaatgcc ctggacacac gtctagggta ggaaagttga     1800

ctgatccatt ggtgatctga gtttttagac atggtggtag tccatgaggt gggtgttcat     1860

gctaagagtt tagacaggga aacctatgaa gcccttagca accctccagg gaaggggcgt     1920

ggttaaagag atgtttcata agtaacagca tggtatagaa actctgaacc ccaaatgtat     1980

gggtcctcag gaacacccca gactttagaa ggaaagtcag aaggtgctga cacgggtgta     2040

taactaaagg gaaatccttc tttctcagct ccaaccatgg ctgtgaggtt cattcacact     2100

gacttaaaaa aaaaaatctc agtttactta aaagtaaata gctttttcta taattctggt     2160

ttgctaattt aatcctagtc tccagaccct ggctaaataa atgcccattt ctccagatgg     2220

tctcaagagt ctctggacat cgtgggggcc cttccctgtt ggttggaagg tgcctcagga     2280

agaagggggt ggattctgag ttgagtcaaa acctcaaaga cccctgatgg gaaaagctct     2340

caagtgacca ccgctgtggg ccagaatgca aaactgcagg aacagaacat tcgcaggaac     2400

agaacacagt cgtattaagt gattttcccg agcaggaagt ggcatctggc ctgcggttca     2460

gtagggggag gaaagggtgg gcgcacctgc ccctggctgg cgcacctgcc aggtagcccc     2520

acgcggcacc gcgtgtgccg agcgcccctg aggatggaaa gccccacgcg gggcaggtgg     2580

cacccaccct ccgaagacgg gacgggatgg agcgttgagc ttcggggcag ctccggcccg     2640

gcccgcgctg gagacgcccg catctgccag gatggcgtct catagccctg gtgctcacac     2700

atgacgccag gaagccccag caacagtgac cgcccaggct ctagaaaata ttggacgggg     2760

tggatgaaca cccaagtgcg ctccaggaga agggatttgg caccccaagg ggcttttaaa     2820

acggtaagct tctaggggtg tctttgcccc caataatcca tagaaacaac agtcatctaa     2880

aaatagtctt gttttctgtc ctaagctcct tttaactttg ttagtcatca ccaatcctaa     2940

aataaaaccc gtgtaacgtc tcccctagta gcggctataa acaaacctac gaggaggcag     3000

gaggaagagg aaaggggcgc agggcgctcg gggagcagag ccgggggccc gcggtggccg     3060

cagaggccgg gccggggcgc agaggccggg cgagctggcc gcgctctggg ccgccgcctc     3120

cggaactccc tgcgcctggc gcgcggccac cgtggtcccg gcaacggcat taaacagagg     3180

gaaacagacc cgggattccg tcacccgggc ggggggataa ggacggcttt gagagcagac     3240

aggaaaaggg agcttttctg catggggtga aaaaattatt tattgaagga ggaggaggcg     3300

gcagcggagg aaggggaggg gcgggaggag gaggaagagc cggccgcccc cgccccggcc     3360

ccggctcctc aggagccaag ggcagcctcg ccaggtcggt cccgggctcg aggaccgcgg     3420

ctggggtcga ggggctcagt ctcccacgtg accggctggg cgcgccccgc cagacccggc     3480

ctcgggattc cctcctcccg gcgagtctcc gcccgccccg tcctggaggt ggggagaagg     3540

agggcggggc gggggggacg gaaactctcc ccgccaaatc ctggccccag gcctggggac     3600

actcgcggcg ggaagatttg gaggggaggg gagggggagg ggcgtggggg cgcggcctcg     3660

ctggagtccc cctgaccccc cgacccccgc ccaccggcct gggcgtcctc ccgcggcccc     3720

tcctcccctc ccggcgcccg gtgctctggg gcgcgtgcca cgcctggctc ggcgccgtag     3780

gggcccccgc aggtagagac ccctggaaat ggcctcgacg ccgcaggagc gaggcggcca     3840

ccaccccgct aatccgggca cgtctctcca ggccgaggcc tgcggtggaa aagccggggt     3900

tccatttgtg ctgagtcggg gcggccgaat ggagccaggc ctcgggacgc gggacggacg     3960

ggctctggcc gcgcaccttc gcgggctctg cagcgcccga ccgcctcccc cggcagggag     4020

gaggcgcttg tggggggcac ccacggggca cagtgatccc tgggggtctg cggacctcct     4080

gggccccgca gcagacacga gtttagcctt tgggtttagt ttaaatcaca taagggtgtc     4140

gtgcaatcga tttatggttt ctacacacca gacactttaa cctccaaccc cccccatcca     4200

aagccaacaa gaaaatgcgg tgccgtgttg gcagctgagc tgcgcccgaa gagacgcagg     4260

gagacgtaag agaggaaagt gtgagtggcc ggggggcctc cccccgtcag aagtcgcgca     4320

gtcgcgccca taaaacgccc cctccgggcg gctagggcag gtgagcgcgt ccccgggcct     4380

ccccacgccg gcccctgcca caggccgtct aggtcgagca gatatttaca gaataaaaat     4440

gacaataact cgacgtcccg ggacggccac gcaatctgtt agtaatttag cgggatggga     4500

atttcctttc tagggcctgc cagtgaagcg cttttccaaa tttccacagc gggggaagcc     4560

tgcgatttta cataatgact tcagcatgcc gggctttctc gacacccctc cccggccccc     4620

ggcccccgcc ccccgcccct tttccagcag ggccgggctc cctccggaca cccgcgtgga     4680

ctcaggcgtc ccgtctggcc cgttcgcccc cgtttccccc gccagcccca gcgcccccct     4740

gcccggcccc cggattcccc gttcccgccc ctacgccccc atcccctccc cgtgcgcccc     4800

tccccgtgcg cccccctccc cgtgcgcccc ccctccccgt gcgcccccct ccccgtgcgc     4860

cccccctccc cgggcgcccc cctccccggg cgccccccct ccccgtgcgc ccccccctcc     4920

ccgtgcgccc cccctccccg tgcgcgcccc gcctcttgcg cccctgcccc caggcgagcg     4980

gctgccgcgg cgcggggagg ggcgggcgct cggcgactcg tccccggggc cccgcgcggg     5040

cccgggcagc aggggcgtga tgtcacggca gggagggggc gcgggagccg ccgggccggc     5100

ggggaggcgg gggaggtgtt ttccagcttt aaaaaggcag gaggcagagc gcggccctgc     5160

gtcagagcga gactcagagg ctccgaactc gccggcggag tcgccgcgcc agatcccagc     5220

agcagggcgc gggcaccggg gcgcgggcag ggctcggagc caccgcgcag gtcctagggc     5280

cgcggccggg ccccgccacg cgcgcacacg cccctcgatg                           5320


<210>  816
<211>  361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc3 promoter sequence

<400>  816
gcagccaggc agggtgggcg cgcgtagggg gcggggccgg gcgcgcggca gggcgcgaga       60

gcgcacccgc ggcggcggtg gcggcgactg tgggggggcg gcggggaaca ttggctaagc      120

cgacagtgga ggcttaggca ccggtggcgg gcggctgcgg ttcctggtgc tgctcggcgc      180

gcggccagct ttcggaacgg aacgctcggc gtcgcgggcc ccgcccggaa agtttgccgt      240

ggagtcgcga cctcttggcc cgcgcggccc ggcatgaagc ggcgttgagg agctgctgcc      300

gccgcttgcc gctgccgccg ccgccgcctg aggaggagct gcagcaccct gggccacgcc      360

g                                                                      361


<210>  817
<211>  430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc2 promoter sequence 1

<400>  817
cagagagagg ctgcgttcag actggggcac tgccatcccc tccgcatcat ggggtctgtg       60

gaccaaggta actgactctc gatcccttcc agccttttcc gctcgctcct cccggccctt      120

tcctgctgct cccgtcccgg gcagcacttt cagctcccgg cagaggtcgg tgcgggaggc      180

ctggggaccc cgctcgccct cggcgcacag gtagcggggc ccgcggaggg gcgcccgcgc      240

cccggccagg gaagggacac ttgggaaggc gactttggac aactttacgc gggggcaggg      300

aagtgtccca ggccgggatt ccctaggcca gtctgtcggg aggattttcc tctccacggg      360

acaccgggag ggattctcgc tactaaccgc tggctgttta accgtttcag cactcggctt      420

ttgacagcaa                                                             430


<210>  818
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc2 promoter sequence 2

<400>  818
catcatgggg tctgtggacc aaggtaactg actctcgatc ccttccagcc ttttccgctc       60

gctc                                                                    64


<210>  819
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 response element consensus

<400>  819
cattttttcc at                                                           12


<210>  820
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 response element consensus

<400>  820
tttttcca                                                                 8


<210>  821
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT response elements contained within the Foxp3 enhancer region

<400>  821
acttgaaaat gagataaatg ttcacctatg ttggcttcta gtctctttta tggcttcatt       60

ttttccattt actatagagg ttaagagtgt gggtactgga gccagactgt ctgggacaa       119


<210>  822
<211>  1506
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muE6 IgD/CD8/41BB/CD3z

<400>  822
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtga aggtggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg tagtctctgg attcactttc agtagatatg gcatgtcttg ggttcgccag      180

actccaggca agaggctgga gtgggtcgca accattagtg gtggcggtac ttacatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatcactg tacaagggat      360

aactacggta ggaactacga ctacggtatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctcag gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atcccaaatt      480

gttctcaccc agtctccagc aatcatgtct gcatctccag gggaggaggt caccctaacc      540

tgcagtgcca cctcaagtgt aagttacata cactggttcc agcagaggcc aggcacttct      600

cccaaactct ggatttatag cacatccaac ctggcttctg gagtccctgt tcgcttcagt      660

ggcagtggat atgggacctc ttactctctc acaatcagcc gaatggaggc tgaagatgct      720

gccacttatt actgccagca aaggagtagt tccccattca cgttcggctc ggggacaaag      780

ttggaaataa aagagtctcc aaaggcacag gcctcctcag tgcccactgc acaaccccaa      840

gcagagggca gcctcgccaa ggcaaccaca gccccagcca ccacccgtaa cacaggaaga      900

ggcggcgaag agaagaaaaa ggagaaggag aaagaggaac aagaagagag agagacaaag      960

acaccaatct acatttgggc cccgctcgca ggcacatgtg gagtgctcct cctctccctg     1020

gtgattaccc tgtactgcaa aaggggccgc aaaaaactcc tttacatttt taagcagcct     1080

tttatgaggc cagtacagac gactcaagag gaagacgggt gctcatgccg ctttcctgag     1140

gaggaggaag gagggtgcga actgcgcgtt aagttctccc gatcagccga cgcgcctgct     1200

tacaagcagg gccagaacca actgtacaac gagctgaatc tcggtagacg ggaagagtac     1260

gacgtgttgg acaaacggag aggccgcgac ccagaaatgg gcggcaagcc tcgcaggaaa     1320

aacccccagg agggactgta caatgagttg cagaaagata agatggcaga agcttatagc     1380

gagatcggaa tgaaggggga aaggagacga gggaaaggac acgacggcct ttatcagggc     1440

ctgtccacag caacaaaaga tacgtatgac gccctccata tgcaggcact tccaccacgg     1500

tgataa                                                                1506


<210>  823
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muE6 IgD/CD8/41BB/CD3z

<400>  823

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Val Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr His Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Glu 
                165                 170                 175     


Val Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Phe Gln Gln Arg Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Tyr 
    210                 215                 220                 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Leu Glu Ile Lys Glu Ser Pro Lys Ala Gln Ala Ser 
            260                 265                 270         


Ser Val Pro Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala 
        275                 280                 285             


Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu 
    290                 295                 300                 


Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys 
305                 310                 315                 320 


Thr Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
                325                 330                 335     


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210>  824
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muC2 IgD/CD8/41BB/CD3z

<400>  824
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggagga gtcaggggga ggcttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg attcactttc agtggctatg ccatgtcttg ggttcgccag      180

actccggaga agaggctgga gtgggtcgca accattagta gtggtggtac ttatatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaggtctgag gacacggcca tgtattactg tgcaagactt      360

gggggggata attactacga atacttcgat gtctggggcg cagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

atcacacagt ctacagcttc cttaggtgta tctctggggc agagggccac catctcatgc      540

agggccagca aaagtgtcag tacatctggc tatagttata tgcactggta ccaacagaga      600

ccaggacagc cacccaaact cctcatctat cttgcatcca acctagaatc tggggtccct      660

gccaggttca gtggcagtgg gtctgggaca gacttcaccc tcaacatcca tcctgtggag      720

gaggaggatg ctgcaaccta ttactgtcag cacagtaggg agcttccgtt cacgttcgga      780

ggggggacca agctggagat aaaagagtct ccaaaggcac aggcctcctc agtgcccact      840

gcacaacccc aagcagaggg cagcctcgcc aaggcaacca cagccccagc caccacccgt      900

aacacaggaa gaggcggcga agagaagaaa aaggagaagg agaaagagga acaagaagag      960

agagagacaa agacaccaat ctacatttgg gccccgctcg caggcacatg tggagtgctc     1020

ctcctctccc tggtgattac cctgtactgc aaaaggggcc gcaaaaaact cctttacatt     1080

tttaagcagc cttttatgag gccagtacag acgactcaag aggaagacgg gtgctcatgc     1140

cgctttcctg aggaggagga aggagggtgc gaactgcgcg ttaagttctc ccgatcagcc     1200

gacgcgcctg cttacaagca gggccagaac caactgtaca acgagctgaa tctcggtaga     1260

cgggaagagt acgacgtgtt ggacaaacgg agaggccgcg acccagaaat gggcggcaag     1320

cctcgcagga aaaaccccca ggagggactg tacaatgagt tgcagaaaga taagatggca     1380

gaagcttata gcgagatcgg aatgaagggg gaaaggagac gagggaaagg acacgacggc     1440

ctttatcagg gcctgtccac agcaacaaaa gatacgtatg acgccctcca tatgcaggca     1500

cttccaccac ggtgataa                                                   1518


<210>  825
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muC2 IgD/CD8/41BB/CD3z

<400>  825

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Ile Thr Gln Ser Thr Ala Ser Leu Gly Val Ser Leu Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu 
225                 230                 235                 240 


Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Ser Pro Lys 
            260                 265                 270         


Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln Ala Glu Gly Ser 
        275                 280                 285             


Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg 
    290                 295                 300                 


Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu 
305                 310                 315                 320 


Arg Glu Thr Lys Thr Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
            340                 345                 350         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        355                 360                 365             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    370                 375                 380                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg 
            500                 


<210>  826
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muE6 CD28/CD28/CD28/CD3z

<400>  826
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtga aggtggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg tagtctctgg attcactttc agtagatatg gcatgtcttg ggttcgccag      180

actccaggca agaggctgga gtgggtcgca accattagtg gtggcggtac ttacatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatcactg tacaagggat      360

aactacggta ggaactacga ctacggtatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctcag gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atcccaaatt      480

gttctcaccc agtctccagc aatcatgtct gcatctccag gggaggaggt caccctaacc      540

tgcagtgcca cctcaagtgt aagttacata cactggttcc agcagaggcc aggcacttct      600

cccaaactct ggatttatag cacatccaac ctggcttctg gagtccctgt tcgcttcagt      660

ggcagtggat atgggacctc ttactctctc acaatcagcc gaatggaggc tgaagatgct      720

gccacttatt actgccagca aaggagtagt tccccattca cgttcggctc ggggacaaag      780

ttggaaataa aaaaacacct ttgtccaagt cccctatttc ccggaccttc taagcccttt      840

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc      900

tttattattt tctgggtgag aagcaagcgg tctcggctcc tgcattctga ttacatgaac      960

atgaccccaa gaagaccagg ccccaccagg aaacattacc agccctacgc tccgccacgc     1020

gacttcgctg cctaccggtc ccgcgttaag ttctcccgat cagccgacgc gcctgcttac     1080

aagcagggcc agaaccaact gtacaacgag ctgaatctcg gtagacggga agagtacgac     1140

gtgttggaca aacggagagg ccgcgaccca gaaatgggcg gcaagcctcg caggaaaaac     1200

ccccaggagg gactgtacaa tgagttgcag aaagataaga tggcagaagc ttatagcgag     1260

atcggaatga agggggaaag gagacgaggg aaaggacacg acggccttta tcagggcctg     1320

tccacagcaa caaaagatac gtatgacgcc ctccatatgc aggcacttcc accacggtga     1380

taa                                                                   1383


<210>  827
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muE6 CD28/CD28/CD28/CD3z

<400>  827

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Val Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr His Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Glu 
                165                 170                 175     


Val Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Phe Gln Gln Arg Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Tyr 
    210                 215                 220                 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Leu Glu Ile Lys Lys His Leu Cys Pro Ser Pro Leu 
            260                 265                 270         


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
305                 310                 315                 320 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                325                 330                 335     


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
            340                 345                 350         


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
        355                 360                 365             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    370                 375                 380                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
385                 390                 395                 400 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                405                 410                 415     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            420                 425                 430         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        435                 440                 445             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 


<210>  828
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muC2 CD28/CD28/CD28/CD3z

<400>  828
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggagga gtcaggggga ggcttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg attcactttc agtggctatg ccatgtcttg ggttcgccag      180

actccggaga agaggctgga gtgggtcgca accattagta gtggtggtac ttatatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaggtctgag gacacggcca tgtattactg tgcaagactt      360

gggggggata attactacga atacttcgat gtctggggcg cagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

atcacacagt ctacagcttc cttaggtgta tctctggggc agagggccac catctcatgc      540

agggccagca aaagtgtcag tacatctggc tatagttata tgcactggta ccaacagaga      600

ccaggacagc cacccaaact cctcatctat cttgcatcca acctagaatc tggggtccct      660

gccaggttca gtggcagtgg gtctgggaca gacttcaccc tcaacatcca tcctgtggag      720

gaggaggatg ctgcaaccta ttactgtcag cacagtaggg agcttccgtt cacgttcgga      780

ggggggacca agctggagat aaaaaaacac ctttgtccaa gtcccctatt tcccggacct      840

tctaagccct tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta      900

gtaacagtgg cctttattat tttctgggtg agaagcaagc ggtctcggct cctgcattct      960

gattacatga acatgacccc aagaagacca ggccccacca ggaaacatta ccagccctac     1020

gctccgccac gcgacttcgc tgcctaccgg tcccgcgtta agttctcccg atcagccgac     1080

gcgcctgctt acaagcaggg ccagaaccaa ctgtacaacg agctgaatct cggtagacgg     1140

gaagagtacg acgtgttgga caaacggaga ggccgcgacc cagaaatggg cggcaagcct     1200

cgcaggaaaa acccccagga gggactgtac aatgagttgc agaaagataa gatggcagaa     1260

gcttatagcg agatcggaat gaagggggaa aggagacgag ggaaaggaca cgacggcctt     1320

tatcagggcc tgtccacagc aacaaaagat acgtatgacg ccctccatat gcaggcactt     1380

ccaccacggt gataa                                                      1395


<210>  829
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muC2 CD28/CD28/CD28/CD3z

<400>  829

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Ile Thr Gln Ser Thr Ala Ser Leu Gly Val Ser Leu Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu 
225                 230                 235                 240 


Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Lys His Leu Cys 
            260                 265                 270         


Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val 
        275                 280                 285             


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
    290                 295                 300                 


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
            340                 345                 350         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
        355                 360                 365             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    370                 375                 380                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
385                 390                 395                 400 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                405                 410                 415     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            420                 425                 430         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        435                 440                 445             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460             


<210>  830
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19 IgD/CD8/41BB/CD3z

<400>  830
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagacatac agatgacgca gacgaccagc agcctttccg cttccctggg cgaccgagta      120

accattagtt gtagagcatc tcaggatatt tctaagtatc tgaattggta ccaacagaaa      180

cctgatggca ctgtcaagct cttgatatat cacaccagtc gactccattc aggcgtccct      240

tccagattca gtgggagtgg cagcgggact gattactccc tcactatctc taacctggaa      300

caggaagaca tcgctacata cttctgtcag cagggaaaca ctctccccta tacctttggg      360

ggaggaacca agttggaaat aacaggcggt ggcggatccg gcggtggcgg atccggcggt      420

ggcggatccg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcag agtctccaaa ggcacaggcc tcctcagtgc ccactgcaca accccaagca      840

gagggcagcc tcgccaaggc aaccacagcc ccagccacca cccgtaacac aggaagaggc      900

ggcgaagaga agaaaaagga gaaggagaaa gaggaacaag aagagagaga gacaaagaca      960

ccaatctaca tttgggcccc gctcgcaggc acatgtggag tgctcctcct ctccctggtg     1020

attaccctgt actgcaaaag gggccgcaaa aaactccttt acatttttaa gcagcctttt     1080

atgaggccag tacagacgac tcaagaggaa gacgggtgct catgccgctt tcctgaggag     1140

gaggaaggag ggtgcgaact gcgcgttaag ttctcccgat cagccgacgc gcctgcttac     1200

aagcagggcc agaaccaact gtacaacgag ctgaatctcg gtagacggga agagtacgac     1260

gtgttggaca aacggagagg ccgcgaccca gaaatgggcg gcaagcctcg caggaaaaac     1320

ccccaggagg gactgtacaa tgagttgcag aaagataaga tggcagaagc ttatagcgag     1380

atcggaatga agggggaaag gagacgaggg aaaggacacg acggccttta tcagggcctg     1440

tccacagcaa caaaagatac gtatgacgcc ctccatatgc aggcacttcc accacggtga     1500

taa                                                                   1503


<210>  831
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 IgD/CD8/41BB/CD3z

<400>  831

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Glu Ser Pro Lys Ala Gln Ala Ser Ser 
            260                 265                 270         


Val Pro Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr 
        275                 280                 285             


Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys 
    290                 295                 300                 


Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr 
305                 310                 315                 320 


Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


