                         SEQUENCE LISTING

<110>  AFFIBODY AB
 
<120>  POLYPEPTIDE, POPULATION AND METHODS

<130>  21105266

<150>  EP18161507.1
<151>  2018-03-13

<160>  173   

<170>  PatentIn version 3.5

<210>  1
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  1

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Asn Glu Ala Ile Ile Ser Lys Ile Glu Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Glu Tyr Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  2
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  2

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Val Ala Asn Leu Lys Lys Lys Ile Glu Ile Ala Lys Ser Val Glu 
            20                  25                  30          


Gln Val Glu Phe Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  3
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  3

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Asp Glu Trp Gln Lys Ser Ala Ile Glu Arg Ala Gln Ala Val Glu 
            20                  25                  30          


Glu Val Glu Phe Trp Lys Glu Asp Ile Leu Ala Gly Leu Pro 
        35                  40                  45      


<210>  4
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  4

Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Asp Ala Asp Leu Ile Lys Lys Ile Glu Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Glu Phe Trp Lys Glu Glu Ile Leu Ala His Leu Pro 
        35                  40                  45      


<210>  5
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  5

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Asn Glu Val Gln Lys Ser Lys Ile Glu Gln Ala Ser Ser Val Glu 
            20                  25                  30          


Glu Val Glu Phe Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  6
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  6

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Val Ala Asn Leu Lys Lys Lys Ile Glu Ile Ala Lys Ser Val Glu 
            20                  25                  30          


Gln Val Glu Phe Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  7
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  7

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Asn Glu Ala Ile Ile Ser Lys Ile Glu Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Glu Tyr Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  8
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  8

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Ile Thr Glu Glu Leu Ile Ser Lys Ile Glu His Ala Gly Ser Val Glu 
            20                  25                  30          


Glu Val Glu Trp Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  9
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  9

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Asp Glu Trp Ser Ile Lys Lys Ile Glu Ala Ala Lys Ile Val Glu 
            20                  25                  30          


Glu Val Glu Phe Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  10
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  10

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val His Asp Ala His Lys Glu Arg Ile Glu Arg Ala Tyr Ser Val Glu 
            20                  25                  30          


Gln Val Glu Phe Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  11
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  11

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Lys Glu His Asn Ile Ser Lys Ile Glu Lys Ala Leu Ser Val Glu 
            20                  25                  30          


Glu Val Glu Tyr Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  12
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  12

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Thr Ala Val Leu Lys Ser Lys Ile Glu Lys Ala Val Ser Val Glu 
            20                  25                  30          


Ala Val Glu Phe Trp Lys Glu Glu Ile Leu Ala Tyr Leu Pro 
        35                  40                  45      


<210>  13
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  13

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Ile Tyr Asp Ser Arg Lys Ser Lys Ile Glu Asn Ala Gln Ile Val Glu 
            20                  25                  30          


Glu Val Glu Phe Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  14
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  14

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Ser Asp Asn Leu Lys Ser Lys Ile Glu Arg Gly Leu Ser Val Glu 
            20                  25                  30          


Glu Val Glu Phe Trp Lys Glu Glu Ile Leu Ala Tyr Leu Pro 
        35                  40                  45      


<210>  15
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  15

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Ile Gln Asp Ala Trp Ile Ser Trp Ile Glu Arg Ala Tyr Ser Val Glu 
            20                  25                  30          


Glu Val Glu Phe Lys Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  16
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  16

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val His Asp Ala His Ile Ser Lys Ile Glu Trp Ala Ala Ala Val Glu 
            20                  25                  30          


Glu Val Glu Phe Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  17
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  17

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Asp Glu Trp Gln Lys Ser Thr Ile Glu Arg Ala Gln Ala Val Glu 
            20                  25                  30          


Glu Val Glu Phe Trp Lys Glu Asp Ile Leu Ala Gly Leu Pro 
        35                  40                  45      


<210>  18
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  18

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Asn Glu Ala Ile Ile Lys Lys Ile Glu Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Glu Tyr Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  19
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  19

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Asn Glu Ala Ile Ile Lys Lys Ile Glu Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Glu Tyr Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  20
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  20

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Ser Glu Ala Ile Ile Lys Lys Ile Glu Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Glu Tyr Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  21
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  21

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Asn Ala Ala Ile Ile Lys Lys Ile Glu Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Glu Tyr Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  22
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  22

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Asn Glu Ala Ile Lys Lys Lys Ile Glu Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Glu Tyr Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  23
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  23

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Asn Glu Ala Ile Ile Lys Lys Ile Gln Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Glu Tyr Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  24
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  24

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Asn Glu Ala Ile Ile Lys Lys Ile Glu Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Gln Tyr Trp Lys Glu Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  25
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  25

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Asn Glu Ala Ile Ile Lys Lys Ile Glu Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Glu Tyr Trp Lys Gln Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  26
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  26

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Asn Glu Ala Ile Ile Lys Lys Ile Glu Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Gln Tyr Trp Lys Gln Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  27
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  27

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Asn Glu Ala Ile Ile Lys Lys Ile Glu Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Gln Tyr Trp Lys Glu Glu Ile Leu Lys Gln Leu Pro 
        35                  40                  45      


<210>  28
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  28

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Asn Glu Ala Ile Ile Lys Lys Ile Glu Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Gln Tyr Trp Lys Gln Glu Ile Leu Lys Gln Leu Pro 
        35                  40                  45      


<210>  29
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  29

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Ala Ile Ile Lys Lys Ile Gln Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Gln Tyr Trp Lys Gln Glu Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  30
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  30

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Ala Ile Ile Lys Lys Ile Gln Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Gln Tyr Trp Lys Gln Glu Ile Leu Ala Gln Leu Pro Ala Ser 
        35                  40                  45              


Tyr Gly Ser 
    50      


<210>  31
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  31

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Ala Ile Ile Lys Lys Ile Gln Arg Ala Glu Ser Val Glu 
            20                  25                  30          


Glu Val Gln Tyr Trp Lys Gln Glu Ile Leu Ala Gln Leu Pro Gly Tyr 
        35                  40                  45              


Ser 
    


<210>  32
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  32

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Asp Leu Ile Lys Lys Ile Gln Gln Ala Ser Ser Val Glu 
            20                  25                  30          


Gly Val Gln Phe Trp Lys Gln Glu Ile Leu Ala Gln Leu Pro Ala 
        35                  40                  45          


<210>  33
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  33

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Met Trp Ile Lys Tyr Ile Gln Arg Ala Lys Asp Val Glu 
            20                  25                  30          


Gly Val Gln Lys Trp Lys Gln Gly Ile Leu Ala Leu Leu Pro Ala 
        35                  40                  45          


<210>  34
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  34

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Glu Glu Ile Lys Trp Ile Gln Asn Ala Trp Ser Val Glu 
            20                  25                  30          


Gly Val Gln Ile Met Lys Gln Gln Ile Leu Ala Glu Leu Pro Ala 
        35                  40                  45          


<210>  35
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  35

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Asp Leu Ile Lys Lys Ile Gln Lys Ala Glu Ser Val Glu 
            20                  25                  30          


Gly Val Gln Phe Trp Lys Gln Glu Ile Leu Ala Thr Leu Pro Ala 
        35                  40                  45          


<210>  36
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  36

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Asp Leu Ile Lys Lys Ile Gln Tyr Ala Asp Thr Val Glu 
            20                  25                  30          


Gly Val Gln Phe Trp Lys Gln Glu Ile Leu Ala Trp Leu Pro Ala 
        35                  40                  45          


<210>  37
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  37

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Glu Leu Ile Lys Lys Ile Gln His Ala Glu Ser Val Glu 
            20                  25                  30          


Gly Val Gln Phe Trp Lys Gln Glu Ile Leu Ala Tyr Leu Pro Ala 
        35                  40                  45          


<210>  38
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  38

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Ala Glu Ile Lys Trp Ile Gln His Ala Ser Thr Val Glu 
            20                  25                  30          


Gly Val Gln Gly Arg Lys Gln Gln Ile Leu Ala Glu Leu Pro Ala 
        35                  40                  45          


<210>  39
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  39

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Asp Asp Ile Lys Leu Ile Gln Asp Ala Pro Ser Val Glu 
            20                  25                  30          


Gly Val Gln Glu Ile Lys Gln Phe Ile Leu Ala Gln Leu Pro Ala 
        35                  40                  45          


<210>  40
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  40

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Asp Leu Ile Lys Lys Ile Gln Gln Ala Ser Ser Val Glu 
            20                  25                  30          


Gly Val Gln Phe Trp Lys Gln Glu Ile Leu Ala Gln Leu Pro Ala 
        35                  40                  45          


<210>  41
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  41

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Asp Leu Ile Lys Lys Ile Gln Gln Ala Ser Ser Val Glu 
            20                  25                  30          


Gly Val Gln Phe Trp Lys Gln Glu Ile Leu Ala Gln Leu Pro Ala 
        35                  40                  45          


<210>  42
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  42

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Asp Leu Ile Lys Lys Ile Glu Gln Ala Ser Ser Val Glu 
            20                  25                  30          


Gly Val Gln Phe Trp Lys Gln Glu Ile Leu Ala Gln Leu Pro Ala 
        35                  40                  45          


<210>  43
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  43

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Glu Leu Ile Lys Lys Ile Gln His Ala Glu Ser Val Glu 
            20                  25                  30          


Gly Val Gln Phe Trp Lys Gln Glu Ile Leu Ala Tyr Leu Pro Ala 
        35                  40                  45          


<210>  44
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  44

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Glu Leu Ile Lys Lys Ile Gln His Ala Glu Ser Val Glu 
            20                  25                  30          


Gly Val Gln Phe Trp Lys Gln Glu Ile Leu Ala Tyr Leu Pro Ala 
        35                  40                  45          


<210>  45
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  45

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Glu Leu Ile Lys Lys Ile Glu His Ala Glu Ser Val Glu 
            20                  25                  30          


Gly Val Gln Phe Trp Lys Gln Glu Ile Leu Ala Tyr Leu Pro Ala 
        35                  40                  45          


<210>  46
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  46

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Asp Leu Ile Lys Lys Ile Glu Gln Ala Ser Ser Val Glu 
            20                  25                  30          


Gly Val Gln Phe Trp Lys Gln Glu Ile Leu Ala Gln Leu Pro Ala 
        35                  40                  45          


<210>  47
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  47

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Asp Leu Ile Lys Lys Ile Glu Lys Ala Glu Ser Val Glu 
            20                  25                  30          


Gly Val Gln Phe Trp Lys Gln Glu Ile Leu Ala Thr Leu Pro Ala 
        35                  40                  45          


<210>  48
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered C4 binding Y variant

<400>  48

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Glu Leu Ile Lys Lys Ile Glu His Ala Glu Ser Val Glu 
            20                  25                  30          


Gly Val Gln Phe Trp Lys Gln Glu Ile Leu Ala Tyr Leu Pro Ala 
        35                  40                  45          


<210>  49
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  49

Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Ile Lys Glu Ile Asn Lys Glu His Ile Glu Leu Ala Glu Ile Val Glu 
            20                  25                  30          


Leu Val Glu Leu Leu Lys Glu Glu Ile Leu Lys Lys Leu Pro 
        35                  40                  45      


<210>  50
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  50

Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gln Ala Asn Ser Ile Glu Ala Ile Glu Gln Gly Leu Phe Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Leu Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  51
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  51

Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gln Asp Arg Ser Ile Ser Lys Ile Glu Ala Gly Tyr Phe Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Leu Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  52
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  52

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val His Ala His Ala Lys Ser Ser Ile Glu Ser Ala Leu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Asn Ile Leu Ala Thr Leu Pro 
        35                  40                  45      


<210>  53
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  53

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Ile Gln Asp Glu Asp Ile Ser Ile Ile Glu Glu Ala Leu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Leu Ile Leu Ala Ser Leu Pro 
        35                  40                  45      


<210>  54
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  54

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Gln Glu Glu Arg Ile Glu Val Ile Glu Ala Gly Leu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  55
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  55

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Asp Asp Ile Asp Lys Lys Val Ile Glu Glu Gly Leu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  56
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  56

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Ile His Glu Gln Ser Ile Lys Ser Ile Glu Glu Ala Leu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Ser Ile Leu Ala Val Leu Pro 
        35                  40                  45      


<210>  57
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  57

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Asn Asp Ile Gln Ile Glu Leu Ile Glu Lys Gly Leu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Leu Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  58
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  58

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Lys Glu Leu Glu Ile Lys Ala Ile Glu His Ala Leu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Asn Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  59
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  59

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Thr Glu Val Ser Lys Ser Phe Ile Glu Ser Gly Glu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Leu Ile Leu Ala Thr Leu Pro 
        35                  40                  45      


<210>  60
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  60

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Asp Ala Val Gln Ile Ser Glu Ile Glu Arg Gly Glu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Ile Ile Leu Ala Val Leu Pro 
        35                  40                  45      


<210>  61
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  61

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Glu Glu Lys Ser Ile Ser Glu Ile Glu Ala Gly Leu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Ser Ile Leu Ala Val Leu Pro 
        35                  40                  45      


<210>  62
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  62

Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Ala Glu Ile Glu Lys Glu Glu Ile Glu Lys Gly Leu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Asn Ile Leu Ala Ser Leu Pro 
        35                  40                  45      


<210>  63
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  63

Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Asp Ala Glu Arg Ile Glu Ile Ile Glu Glu Gly Leu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Asn Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  64
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  64

Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Thr Ala Lys Arg Lys Ser Ala Ile Glu Ser Gly Leu Phe Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Asn Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  65
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  65

Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Val Asp Asp Ser Ile Lys Arg Ile Glu His Gly Leu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Ile Lys Glu Asn Ile Leu Ala Val Leu Pro 
        35                  40                  45      


<210>  66
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  66

Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Tyr Glu Gly Arg Ile Ser Thr Ile Glu Gln Gly Leu Phe Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Leu Ile Leu Ala Thr Leu Pro 
        35                  40                  45      


<210>  67
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  67

Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Thr Glu Tyr Lys Ile Glu Thr Ile Glu Gln Gly Leu Trp Val Glu 
            20                  25                  30          


Leu Val Glu Leu Leu Lys Glu Asn Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  68
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  68

Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Ile Ser Asp Gln Gln Ile Glu Ser Ile Glu Arg Gly Leu Trp Val Glu 
            20                  25                  30          


Val Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Val Leu Pro 
        35                  40                  45      


<210>  69
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  69

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Ile Asp Glu Phe His Lys Ser Tyr Ile Glu Gln Ala Gly Gly Val Glu 
            20                  25                  30          


Glu Val Glu Trp Tyr Lys Glu Ile Ile Leu Lys Ser Leu Pro 
        35                  40                  45      


<210>  70
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  70

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Asp Thr Ile Lys Asp Ile Gln Pro Ala Ile Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  71
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  71

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Asp Gly Ile Lys Glu Ile Gln Gln Ala Met Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  72
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  72

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Ala Glu Ile Lys Arg Ile Gln Ala Ala Glu Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  73
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  73

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Arg Asp Ile Lys Leu Ile Gln Glu Ala Met Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  74
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  74

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Gly Asp Ile Lys Asp Ile Gln Asp Ala Leu Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  75
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  75

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Val Glu Ile Lys Gln Ile Gln Glu Ala Leu Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  76
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  76

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala His Gly Ile Lys Glu Ile Gln Asp Ala Ile Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Ala Leu Pro Ala 
        35                  40                  45          


<210>  77
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  77

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Ile Ile Lys Asp Ile Gln Leu Ala Met Met Val Glu 
            20                  25                  30          


Ile Val Gln Met Leu Lys Gln Ala Ile Leu Ala Ser Leu Pro Ala 
        35                  40                  45          


<210>  78
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  78

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Asn His Ile Lys Ala Ile Gln His Ala Gln Phe Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  79
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  79

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Glu Glu Ile Lys Glu Ile Gln Gly Ala Met Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  80
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  80

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala His Glu Ile Lys Glu Ile Gln Ile Ala Glu Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  81
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  81

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Val Glu Ile Lys Gln Ile Gln Glu Ala Leu Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  82
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  82

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Val Glu Ile Lys Gln Ile Gln Glu Ala Leu Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  83
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  83

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Val Glu Ile Lys Gln Ile Glu Glu Ala Leu Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  84
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  84

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Gly Asp Ile Lys Asp Ile Gln Asp Ala Leu Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  85
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  85

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Gly Asp Ile Lys Asp Ile Gln Asp Ala Leu Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  86
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  86

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Gly Asp Ile Lys Asp Ile Glu Asp Ala Leu Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  87
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  87

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Val Glu Ile Lys Gln Ile Glu Glu Ala Leu Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  88
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  88

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Ala Glu Ile Lys Arg Ile Glu Ala Ala Glu Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  89
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered IL-6 binding Y variant

<400>  89

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Gly Asp Ile Lys Asp Ile Glu Asp Ala Leu Leu Val Glu 
            20                  25                  30          


Ile Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Val Leu Pro Ala 
        35                  40                  45          


<210>  90
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  90

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Lys Ser Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  91
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  91

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Gly Glu Arg Gln Ile Lys Trp Ile Glu Asn Ala Trp Ser Val Glu 
            20                  25                  30          


Val Val Glu Trp Leu Lys Glu Gln Ile Leu Lys Glu Leu Pro 
        35                  40                  45      


<210>  92
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  92

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Asn Glu Arg Glu Lys Lys Trp Ile Glu Asp Ala Gln His Val Glu 
            20                  25                  30          


Val Val Glu Trp Leu Lys Glu Arg Ile Leu Lys Ser Leu Pro 
        35                  40                  45      


<210>  93
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  93

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Asp Ala Arg Phe Lys Glu Trp Ile Glu Asn Ala Trp Ser Val Glu 
            20                  25                  30          


Thr Val Glu Trp Leu Lys Glu Asn Ile Leu Lys Ala Leu Pro 
        35                  40                  45      


<210>  94
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  94

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Ile Asn Asp His Tyr Lys Lys Ile Ile Glu Arg Ala Trp Arg Val Glu 
            20                  25                  30          


Gln Val Glu Trp Ala Lys Glu Ala Ile Leu Lys Asp Leu Pro 
        35                  40                  45      


<210>  95
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  95

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Asp Glu Arg Lys Ile Ser Trp Ile Glu Arg Ala Gly His Val Glu 
            20                  25                  30          


Val Val Glu Trp Leu Lys Glu Arg Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  96
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  96

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Lys Ala Leu Val Ile Glu Ile Ile Glu Ser Ala His Ser Val Glu 
            20                  25                  30          


Glu Val Glu Gln Val Lys Glu Phe Ile Leu Ala Lys Leu Pro 
        35                  40                  45      


<210>  97
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  97

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Ile Lys Ala Ser Leu Lys Glu Ile Ile Glu His Ala Ser Asp Val Glu 
            20                  25                  30          


Glu Val Glu Lys Ile Lys Glu Arg Ile Leu Ala Lys Leu Pro 
        35                  40                  45      


<210>  98
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  98

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Thr Asp Val Arg Lys Ser Trp Ile Glu Lys Ala Gln Arg Val Glu 
            20                  25                  30          


Val Val Glu Trp Leu Lys Glu Arg Ile Leu Ala Glu Leu Pro 
        35                  40                  45      


<210>  99
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  99

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Ala Ala Phe Gln Ile Ser Trp Ile Glu Lys Ala Ser Ser Val Glu 
            20                  25                  30          


Val Val Glu Trp Leu Lys Glu Ala Ile Leu Ala Glu Leu Pro 
        35                  40                  45      


<210>  100
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  100

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Val Glu Val Gln Lys Glu Trp Ile Glu Arg Ala His Ser Val Glu 
            20                  25                  30          


Val Val Glu Trp Leu Lys Glu Arg Ile Leu Ala Gln Leu Pro 
        35                  40                  45      


<210>  101
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  101

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Asp Ala Arg Phe Ile Lys Trp Ile Glu Thr Ala His Gln Val Glu 
            20                  25                  30          


Val Val Glu Tyr Phe Lys Glu Arg Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  102
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  102

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Ser Glu Gly Phe Ile Lys Trp Ile Glu Gln Ala Ser Tyr Val Glu 
            20                  25                  30          


Val Val Glu Trp Leu Lys Glu Arg Ile Leu Lys Asp Leu Pro 
        35                  40                  45      


<210>  103
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  103

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val His Glu Arg Phe Ile Glu Trp Ile Glu Gly Ala His Ser Val Glu 
            20                  25                  30          


Val Val Glu Trp Leu Lys Glu Gln Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  104
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  104

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Gly Ala Gly Trp Lys Ser Leu Ile Glu Gly Ala Glu His Val Glu 
            20                  25                  30          


Thr Val Glu Trp Phe Lys Glu Arg Ile Leu Lys Asp Leu Pro 
        35                  40                  45      


<210>  105
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  105

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Thr Asp Arg Lys Ile Ser Trp Ile Glu Glu Ala Ser Ser Val Glu 
            20                  25                  30          


Val Val Glu Trp Leu Lys Glu Arg Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  106
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  106

Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Lys Ser Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  107
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  107

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Glu Glu Lys Trp Ile Lys Val Ile Glu Gly Ala Trp Ser Val Glu 
            20                  25                  30          


Val Val Glu Trp Phe Lys Glu Arg Ile Leu Lys Asp Leu Pro 
        35                  40                  45      


<210>  108
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  108

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Val Gln Ala Lys Phe Ile Lys Trp Ile Glu Lys Ala Glu His Val Glu 
            20                  25                  30          


Thr Val Glu Trp Leu Lys Glu Arg Ile Leu Lys Asp Leu Pro 
        35                  40                  45      


<210>  109
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  109

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Ala Gly 
1               5                   10                  15      


Ile Tyr Asp Gly Phe Lys Glu Trp Ile Glu Gly Ala Phe His Val Glu 
            20                  25                  30          


Val Val Glu Tyr Leu Lys Glu Arg Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  110
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  110

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Lys Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Lys Ser Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  111
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  111

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Lys Ser Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  112
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  112

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ile Gly Ala Tyr Gln Lys Ser Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  113
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  113

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Ser Ala Tyr Gln Lys Ser Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  114
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  114

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Glu Tyr Gln Lys Ser Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  115
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  115

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Ser Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  116
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  116

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Lys Lys Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  117
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  117

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  118
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  118

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Lys Ser Phe Ile Gln Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  119
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  119

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Lys Ser Phe Ile Glu Leu Gly Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  120
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  120

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Lys Ser Phe Ile Glu Leu Ala Lys Ser Val Gln 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  121
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  121

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Lys Ser Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Gln Leu Leu Lys Glu Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  122
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  122

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Lys Ser Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Gln Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  123
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  123

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Lys Ser Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Glu Leu Leu Lys Glu Ala Ile Leu Lys Asp Leu Pro 
        35                  40                  45      


<210>  124
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  124

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Lys Lys Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  125
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  125

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  126
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  126

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Gln Leu Leu Lys Glu Ala Ile Leu Lys Asp Leu Pro 
        35                  40                  45      


<210>  127
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  127

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Glu Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Gln Leu Leu Lys Gln Ala Ile Leu Lys Asp Leu Pro 
        35                  40                  45      


<210>  128
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  128

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Gln Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Asp Leu Pro 
        35                  40                  45      


<210>  129
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  129

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Gln Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Asp Leu Pro Ala Ser 
        35                  40                  45              


Tyr Gly Ser 
    50      


<210>  130
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  130

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Gln Leu Ala Lys Ser Val Glu 
            20                  25                  30          


His Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Asp Leu Pro Gly Tyr 
        35                  40                  45              


Ser 
    


<210>  131
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  131

Thr Ile Asp Glu Trp Leu Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala 
1               5                   10                  15      


Glu Leu Asp Ser Lys Gly Val Gly Ala Tyr Gln Ile Lys Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Ser Val Glu His Val Gln Leu Leu Lys Gln Ala Ile Leu 
        35                  40                  45              


Ala Asp Leu Pro 
    50          


<210>  132
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  132

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Gln Val Ala Lys Thr Val Glu 
            20                  25                  30          


Gln Val Gln Ile Leu Lys Gln Ala Ile Leu Ala Asp Leu Pro Ala 
        35                  40                  45          


<210>  133
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  133

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Arg Gln Ile Lys Trp Ile Gln Gln Ala Lys Ser Val Glu 
            20                  25                  30          


Val Val Gln Trp Leu Lys Gln Ala Ile Leu Ala Asp Leu Pro Ala 
        35                  40                  45          


<210>  134
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  134

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Gln Val Ala His Asp Val Glu 
            20                  25                  30          


Glu Val Gln Ile Leu Lys Gln Ala Ile Leu Ala Asp Leu Pro Ala 
        35                  40                  45          


<210>  135
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  135

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Gln Ile Ala His Thr Val Glu 
            20                  25                  30          


Glu Val Gln Leu Met Lys Gln Ala Ile Leu Ala Asp Leu Pro Ala 
        35                  40                  45          


<210>  136
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  136

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Lys Tyr Ile Lys Met Ile Gln Met Ala Lys His Val Glu 
            20                  25                  30          


Thr Val Gln Tyr Met Lys Gln Ala Ile Leu Ala Ser Leu Pro Ala 
        35                  40                  45          


<210>  137
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  137

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Leu Ile Lys Phe Ile Gln Ile Ala Lys Asn Val Glu 
            20                  25                  30          


Ala Val Gln Phe Leu Lys Gln Ala Ile Leu Ala Asp Leu Pro Ala 
        35                  40                  45          


<210>  138
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  138

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Gln Val Ala Lys Thr Val Glu 
            20                  25                  30          


Ala Val Gln Ala Ile Lys Gln Ala Ile Leu Ala Asp Leu Pro Ala 
        35                  40                  45          


<210>  139
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  139

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Lys Glu Ile Lys Trp Ile Gln Met Ala Ser His Val Glu 
            20                  25                  30          


Val Val Gln Trp Leu Lys Gln Ala Ile Leu Ala Ser Leu Pro Ala 
        35                  40                  45          


<210>  140
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  140

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Lys Tyr Ile Lys Met Ile Gln His Ala His Tyr Val Glu 
            20                  25                  30          


Val Val Gln Trp Leu Lys Gln Ala Ile Leu Ala His Leu Pro 
        35                  40                  45      


<210>  141
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  141

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Lys Tyr Ile Lys Met Ile Gln His Ala His Tyr Val Glu 
            20                  25                  30          


Val Val Gln Trp Leu Lys Gln Ala Ile Leu Ala His Leu Pro Ala 
        35                  40                  45          


<210>  142
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  142

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Ala Lys Ile Lys Trp Ile Gln Asp Ala Lys Ser Val Glu 
            20                  25                  30          


Thr Val Gln Phe Leu Lys Gln Ala Ile Leu Ala Glu Leu Pro Ala 
        35                  40                  45          


<210>  143
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  143

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Trp Ile Lys Ala Ile Gln Gln Ala Tyr Tyr Val Glu 
            20                  25                  30          


Met Val Gln Trp Phe Lys Gln Ala Ile Leu Ala His Leu Pro Ala 
        35                  40                  45          


<210>  144
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  144

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Lys Phe Ile Lys Met Ile Gln Ser Ala Lys Leu Val Glu 
            20                  25                  30          


Thr Val Gln Leu Leu Lys Gln Ala Ile Leu Ala Asp Leu Pro Ala 
        35                  40                  45          


<210>  145
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  145

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Lys Tyr Ile Lys Tyr Ile Gln Lys Ala Trp Thr Val Glu 
            20                  25                  30          


Gly Val Gln Tyr Leu Lys Gln Ala Ile Leu Ala Ser Leu Pro Ala 
        35                  40                  45          


<210>  146
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  146

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Lys Tyr Ile Lys Met Ile Gln His Ala His Tyr Val Glu 
            20                  25                  30          


Val Val Gln Trp Leu Lys Gln Ala Ile Leu Ala His Leu Pro 
        35                  40                  45      


<210>  147
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  147

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Lys Tyr Ile Lys Met Ile Glu His Ala His Tyr Val Glu 
            20                  25                  30          


Val Val Gln Trp Leu Lys Gln Ala Ile Leu Ala His Leu Pro 
        35                  40                  45      


<210>  148
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  148

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Lys Tyr Ile Lys Met Ile Gln His Ala His Tyr Val Glu 
            20                  25                  30          


Val Val Gln Trp Leu Lys Gln Ala Ile Leu Ala His Leu Pro 
        35                  40                  45      


<210>  149
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  149

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Ala Lys Ile Lys Trp Ile Gln Asp Ala Lys Ser Val Glu 
            20                  25                  30          


Thr Val Gln Phe Leu Lys Gln Ala Ile Leu Ala Glu Leu Pro Ala 
        35                  40                  45          


<210>  150
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  150

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Ala Lys Ile Lys Trp Ile Gln Asp Ala Lys Ser Val Glu 
            20                  25                  30          


Thr Val Gln Phe Leu Lys Gln Ala Ile Leu Ala Glu Leu Pro Ala 
        35                  40                  45          


<210>  151
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  151

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Ala Lys Ile Lys Trp Ile Glu Asp Ala Lys Ser Val Glu 
            20                  25                  30          


Thr Val Gln Phe Leu Lys Gln Ala Ile Leu Ala Glu Leu Pro Ala 
        35                  40                  45          


<210>  152
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  152

Leu Ala Glu Ala Lys Glu Ala Ala Leu Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Gln Ile Ala His Thr Val Glu 
            20                  25                  30          


Glu Val Gln Leu Met Lys Gln Ala Ile Leu Ala Asp Leu Pro Ala 
        35                  40                  45          


<210>  153
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  153

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Gln Ile Ala His Thr Val Glu 
            20                  25                  30          


Glu Val Gln Leu Met Lys Gln Ala Ile Leu Ala Asp Leu Pro Ala 
        35                  40                  45          


<210>  154
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  154

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Lys Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Glu Ile Ala His Thr Val Glu 
            20                  25                  30          


Glu Val Gln Leu Met Lys Gln Ala Ile Leu Ala Asp Leu Pro Ala 
        35                  40                  45          


<210>  155
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  155

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Ala Lys Ile Lys Trp Ile Glu Asp Ala Lys Ser Val Glu 
            20                  25                  30          


Thr Val Gln Phe Leu Lys Gln Ala Ile Leu Ala Glu Leu Pro Ala 
        35                  40                  45          


<210>  156
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  156

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Arg Gln Ile Lys Trp Ile Glu Gln Ala Lys Ser Val Glu 
            20                  25                  30          


Val Val Gln Trp Leu Lys Gln Ala Ile Leu Ala Asp Leu Pro Ala 
        35                  40                  45          


<210>  157
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered insulin binding Y variant

<400>  157

Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Gly Ala Tyr Gln Ile Lys Phe Ile Glu Ile Ala His Thr Val Glu 
            20                  25                  30          


Glu Val Gln Leu Met Lys Gln Ala Ile Leu Ala Asp Leu Pro Ala 
        35                  40                  45          


<210>  158
<211>  46
<212>  PRT
<213>  Streptococcus sp. G148

<400>  158

Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
1               5                   10                  15      


Val Ser Asp Tyr Tyr Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu 
            20                  25                  30          


Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  159
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered ABD variant

<400>  159

Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      


Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu 
            20                  25                  30          


Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  160
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Taq binding Z variant

<400>  160

Val Asp Asn Lys Phe Asn Lys Glu Leu Gly Trp Ala Thr Trp Glu Ile 
1               5                   10                  15      


Phe Asn Leu Pro Asn Leu Asn Gly Val Gln Val Lys Ala Phe Ile Asp 
            20                  25                  30          


Ser Leu Arg Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  161
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered fusion of insulin-binding variant and ABD variant

<400>  161

Gly Ser Ser Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala Glu Leu Asp 
1               5                   10                  15      


Ser Lys Gly Val Gly Ala Lys Tyr Ile Lys Met Ile Gln His Ala His 
            20                  25                  30          


Tyr Val Glu Val Val Gln Trp Leu Lys Gln Ala Ile Leu Ala His Leu 
        35                  40                  45              


Pro Gly Gly Gly Gly Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala 
    50                  55                  60                  


Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp 
65                  70                  75                  80  


Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu 
                85                  90                  95      


Ala Ala Leu Pro 
            100 


<210>  162
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered fusion of ABD variant and insulin-binding variant

<400>  162

Gly Ser Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp 
1               5                   10                  15      


Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys 
            20                  25                  30          


Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu 
        35                  40                  45              


Pro Gly Gly Gly Gly Ser Leu Ala Glu Ala Lys Glu Ala Ala Ile Ala 
    50                  55                  60                  


Glu Leu Asp Ser Lys Gly Val Gly Ala Lys Tyr Ile Lys Met Ile Gln 
65                  70                  75                  80  


His Ala His Tyr Val Glu Val Val Gln Trp Leu Lys Gln Ala Ile Leu 
                85                  90                  95      


Ala His Leu Pro 
            100 


<210>  163
<211>  181
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cloning oligo for library #1


<220>
<221>  variation
<222>  (42)..(44)
<223>  Codon encoding any amino acid

<220>
<221>  misc_feature
<222>  (42)..(44)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (60)..(62)
<223>  Codon encoding any amino acid

<220>
<221>  misc_feature
<222>  (60)..(62)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (66)..(89)
<223>  Codons encoding any amino acid

<220>
<221>  misc_feature
<222>  (66)..(89)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (96)..(107)
<223>  Codons encoding any amino acid

<220>
<221>  misc_feature
<222>  (96)..(107)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (114)..(116)
<223>  Codon encoding any amino acid

<220>
<221>  misc_feature
<222>  (114)..(116)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (123)..(128)
<223>  Codons encoding any amino acid

<220>
<221>  misc_feature
<222>  (123)..(128)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (135)..(137)
<223>  Codon encoding any amino acid

<220>
<221>  misc_feature
<222>  (135)..(137)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (144)..(149)
<223>  Codons encoding any amino acid

<220>
<221>  misc_feature
<222>  (144)..(149)
<223>  n is a, c, g, or t

<400>  163
aaataaatgg atccagcctg gctgaggcga aagaagccgc gnnngccgag ctggatagcn       60

nnggtnnnnn nnnnnnnnnn nnnnnnnnna tcgagnnnnn nnnnnnngtt gagnnngttg      120

aannnnnnaa agaannnatt ctgnnnnnnc tgccggcgag cggtagcgtc gacattattt      180

a                                                                      181


<210>  164
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cloning oligo for library #2


<220>
<221>  variation
<222>  (22)..(27)
<223>  Two codons each encoding any amino acid except C and P

<220>
<221>  misc_feature
<222>  (22)..(27)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (34)..(36)
<223>  Codon encoding any amino acid except C and P

<220>
<221>  misc_feature
<222>  (34)..(36)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (43)..(45)
<223>  Codon encoding any amino acid except C

<220>
<221>  misc_feature
<222>  (43)..(45)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (49)..(54)
<223>  Two codons each encoding any amino acid except C

<220>
<221>  misc_feature
<222>  (49)..(54)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (61)..(63)
<223>  Codon encoding any amino acid except C, 50% G and even 
       distribution of rest

<220>
<221>  misc_feature
<222>  (61)..(63)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (70)..(75)
<223>  Two codons each encoding any amino acid except C and P

<220>
<221>  misc_feature
<222>  (70)..(75)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (82)..(84)
<223>  Codon encoding any amino acid except C, 50% A and even 
       distribution of rest

<220>
<221>  misc_feature
<222>  (82)..(84)
<223>  n is a, c, g, or t

<220>
<221>  variation
<222>  (94)..(96)
<223>  Codon encoding any amino acid except C and P

<220>
<221>  misc_feature
<222>  (94)..(96)
<223>  n is a, c, g, or t

<400>  164
gatagcaaag gtgttggtgc annnnnnatt aaannnattc agnnngcann nnnngttgag       60

nnngttcaan nnnnnaaaca gnnnattctg gcgnnnctgc cggcgagcgg tagcgtc         117


<210>  165
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Short scaffold sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  I or L

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  C or S

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  K or Y

<220>
<221>  VARIANT
<222>  (12)..(13)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  E or Q

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (21)..(22)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (25)..(25)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (28)..(29)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (32)..(32)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (36)..(36)
<223>  Any amino acid

<400>  165

Xaa Ala Glu Leu Asp Xaa Xaa Gly Val Gly Ala Xaa Xaa Ile Lys Xaa 
1               5                   10                  15      


Ile Xaa Xaa Ala Xaa Xaa Val Glu Xaa Val Gln Xaa Xaa Lys Gln Xaa 
            20                  25                  30          


Ile Leu Ala Xaa 
        35      


<210>  166
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Long scaffold sequence


<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  I or L

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  C or S

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  K or Y

<220>
<221>  VARIANT
<222>  (20)..(21)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (26)..(26)
<223>  E or Q

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (29)..(30)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (33)..(33)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (36)..(37)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (40)..(40)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (44)..(44)
<223>  Any amino acid

<400>  166

Leu Ala Glu Ala Lys Glu Ala Ala Xaa Ala Glu Leu Asp Xaa Xaa Gly 
1               5                   10                  15      


Val Gly Ala Xaa Xaa Ile Lys Xaa Ile Xaa Xaa Ala Xaa Xaa Val Glu 
            20                  25                  30          


Xaa Val Gln Xaa Xaa Lys Gln Xaa Ile Leu Ala Xaa Leu Pro 
        35                  40                  45      


<210>  167
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered, His6-tagged Y variant


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid

<400>  167

Met Gly Ser Ser His His His His His His Gly Ser Ser Leu Ala Glu 
1               5                   10                  15      


Ala Lys Glu Ala Ala Xaa Ala Glu Leu Asp Xaa Xaa Gly Val Gly Ala 
            20                  25                  30          


Xaa Xaa Ile Lys Xaa Ile Xaa Xaa Ala Xaa Xaa Val Glu Xaa Val Gln 
        35                  40                  45              


Xaa Xaa Lys Gln Xaa Ile Leu Ala Xaa Leu Pro Ala Ser Gly Ser Val 
    50                  55                  60                  


Asp 
65  


<210>  168
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered, His6-tagged Y variant


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid

<400>  168

Met Gly Ser Ser His His His His His His Gly Ser Ser Leu Ala Glu 
1               5                   10                  15      


Ala Lys Glu Ala Ala Xaa Ala Glu Leu Asp Xaa Xaa Gly Val Gly Ala 
            20                  25                  30          


Xaa Xaa Ile Lys Xaa Ile Xaa Xaa Ala Xaa Xaa Val Glu Xaa Val Gln 
        35                  40                  45              


Xaa Xaa Lys Gln Xaa Ile Leu Ala Xaa Leu Pro 
    50                  55                  


<210>  169
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered, His6-tagged Y variant


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid

<400>  169

Met Gly Ser Ser His His His His His His Gly Ser Ser Leu Ala Glu 
1               5                   10                  15      


Ala Lys Glu Ala Ala Xaa Ala Glu Leu Asp Xaa Xaa Gly Val Gly Ala 
            20                  25                  30          


Xaa Xaa Ile Lys Xaa Ile Xaa Xaa Ala Xaa Xaa Val Glu Xaa Val Gln 
        35                  40                  45              


Xaa Xaa Lys Gln Xaa Ile Leu Ala Xaa Leu Pro Ala Ser Tyr Gly Ser 
    50                  55                  60                  


<210>  170
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered, His6-tagged Y variant


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid

<400>  170

Met Gly Ser Ser His His His His His His Gly Ser Ser Leu Ala Glu 
1               5                   10                  15      


Ala Lys Glu Ala Ala Xaa Ala Glu Leu Asp Xaa Xaa Gly Val Gly Ala 
            20                  25                  30          


Xaa Xaa Ile Lys Xaa Ile Xaa Xaa Ala Xaa Xaa Val Glu Xaa Val Gln 
        35                  40                  45              


Xaa Xaa Lys Gln Xaa Ile Leu Ala Xaa Leu Pro Gly Tyr Ser 
    50                  55                  60          


<210>  171
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered, His6-tagged Y variant


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(31)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (52)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa can be any naturally occurring amino acid

<400>  171

Met Gly Ser Ser His His His His His His Thr Ile Asp Glu Trp Leu 
1               5                   10                  15      


Leu Ala Glu Ala Lys Glu Ala Ala Xaa Ala Glu Leu Asp Xaa Xaa Gly 
            20                  25                  30          


Val Gly Ala Xaa Xaa Ile Lys Xaa Ile Xaa Xaa Ala Xaa Xaa Val Glu 
        35                  40                  45              


Xaa Val Gln Xaa Xaa Lys Gln Xaa Ile Leu Ala Xaa Leu Pro 
    50                  55                  60          


<210>  172
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered, His6-tagged Y variant


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid

<400>  172

Met Gly Ser Ser His His His His His His Gly Ser Ser Leu Ala Glu 
1               5                   10                  15      


Ala Lys Glu Ala Ala Xaa Ala Glu Leu Asp Xaa Xaa Gly Val Gly Ala 
            20                  25                  30          


Xaa Xaa Ile Lys Xaa Ile Xaa Xaa Ala Xaa Xaa Val Glu Xaa Val Gln 
        35                  40                  45              


Xaa Xaa Lys Gln Xaa Ile Leu Ala Xaa Leu Pro Ala 
    50                  55                  60  


<210>  173
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Y variant in fusion with Z03639


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa can be any naturally occurring amino acid

<400>  173

Gly Ser Ser Leu Ala Glu Ala Lys Glu Ala Ala Xaa Ala Glu Leu Asp 
1               5                   10                  15      


Xaa Xaa Gly Val Gly Ala Xaa Xaa Ile Lys Xaa Ile Xaa Xaa Ala Xaa 
            20                  25                  30          


Xaa Val Glu Xaa Val Gln Xaa Xaa Lys Gln Xaa Ile Leu Ala Xaa Leu 
        35                  40                  45              


Pro Ala Ser Gly Ser Val Asp Asn Lys Phe Asn Lys Glu Leu Gly Trp 
    50                  55                  60                  


Ala Thr Trp Glu Ile Phe Asn Leu Pro Asn Leu Asn Gly Val Gln Val 
65                  70                  75                  80  


Lys Ala Phe Ile Asp Ser Leu Arg Asp Asp Pro Ser Gln Ser Ala Asn 
                85                  90                  95      


Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Tyr 
            100                 105                 110         


Val Pro Gly 
        115 


