                         序列表

<110>  傅惠芳
 
<120>  促进局部肌肉增长、减缓或防止局部肌肉萎缩的组合物及其用途

<130>  WPI18TW0254

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  678
<212>  DNA
<213>  Staphylococcus aureus

<400>  1
tcaagtgagt ttactggtct gatggagaat atgaaagttt tatatgatga tcattatgta       60

tcagcaacta aagttatgtc tgtagataaa tttttggcac atgatttaat ttataacatt      120

agtgataaaa aactaaaaaa ttatgacaaa gtgaaaacag agttattaaa tgaagattta      180

gcaaagaagt acaaagatga agtagttgat gtgtatggat caaattacta tgtaaactgc      240

tatttttcat ccaaagataa tgtaggtaaa gttacaggtg gtaaaacttg tatgtatgga      300

ggaataacaa aatatgaagg aaaccacttt gataatggga acttacaaaa tgtacttata      360

agagtttatg aaaataaaag aaacacaatt tcttttgaag tgcaaactga taagaaaagt      420

gtaacagctc aagaactaga cataaaagct aggaattttt taattaataa aaaaaatttg      480

tatgagttta acagttcacc atatgaaaca ggatatataa aatttattga aaataacggc      540

aatacttttt ggtatgatat gatgcctgca ccaggcgata agtttgacca atctaaatat      600

ttaatgatgt acaacgacaa taaaacggtt gattctaaaa gtgtgaagat agaagtccac      660

cttacaacaa agaatgga                                                    678


<210>  2
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  2
gattttggac tcgactgtga tgagcactca acagaatctc gatgc                       45


<210>  3
<211>  954
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  含SEC2片段与肌生成抑制素片段的组合物。

<400>  3
tcaagtgagt ttactggtct gatggagaat atgaaagttt tatatgatga tcattatgta       60

tcagcaacta aagttatgtc tgtagataaa tttttggcac atgatttaat ttataacatt      120

agtgataaaa aactaaaaaa ttatgacaaa gtgaaaacag agttattaaa tgaagattta      180

gcaaagaagt acaaagatga agtagttgat gtgtatggat caaattacta tgtaaactgc      240

tatttttcat ccaaagataa tgtaggtaaa gttacaggtg gtaaaacttg tatgtatgga      300

ggaataacaa aatatgaagg aaaccacttt gataatggga acttacaaaa tgtacttata      360

agagtttatg aaaataaaag aaacacaatt tcttttgaag tgcaaactga taagaaaagt      420

gtaacagctc aagaactaga cataaaagct aggaattttt taattaataa aaaaaatttg      480

tatgagttta acagttcacc atatgaaaca ggatatataa aatttattga aaataacggc      540

aatacttttt ggtatgatat gatgcctgca ccaggcgata agtttgacca atctaaatat      600

ttaatgatgt acaacgacaa taaaacggtt gattctaaaa gtgtgaagat agaagtccac      660

cttacaacaa agaatggact cgaggatttt ggactcgact gtgatgagca ctcaacagaa      720

tctcgatgcg attttggact cgactgtgat gagcactcaa cagaatctcg atgcgatttt      780

ggactcgact gtgatgagca ctcaacagaa tctcgatgcg attttggact cgactgtgat      840

gagcactcaa cagaatctcg atgcgatttt ggactcgact gtgatgagca ctcaacagaa      900

tctcgatgcg attttggact cgactgtgat gagcactcaa cagaatctcg atgc            954


<210>  4
<211>  257
<212>  PRT
<213>  Staphylococcus aureus

<400>  4

Met Lys Lys Thr Ala Phe Thr Leu Leu Leu Phe Ile Ala Leu Thr Leu 
1               5                   10                  15      


Thr Thr Ser Pro Leu Val Asn Gly Ser Glu Lys Ser Glu Glu Ile Asn 
            20                  25                  30          


Glu Lys Asp Leu Arg Lys Lys Ser Glu Leu Gln Gly Thr Ala Leu Gly 
        35                  40                  45              


Asn Leu Lys Gln Ile Tyr Tyr Tyr Asn Glu Lys Ala Lys Thr Glu Asn 
    50                  55                  60                  


Lys Glu Ser His Asp Gln Phe Leu Gln His Thr Ile Leu Phe Lys Gly 
65                  70                  75                  80  


Phe Phe Thr Asp His Ser Trp Tyr Asn Asp Leu Leu Val Asp Phe Asp 
                85                  90                  95      


Ser Lys Asp Ile Val Asp Lys Tyr Lys Gly Lys Lys Val Asp Leu Tyr 
            100                 105                 110         


Gly Ala Tyr Tyr Gly Tyr Gln Cys Ala Gly Gly Thr Pro Asn Lys Thr 
        115                 120                 125             


Ala Cys Met Tyr Gly Gly Val Thr Leu His Asp Asn Asn Arg Leu Thr 
    130                 135                 140                 


Glu Glu Lys Lys Val Pro Ile Asn Leu Trp Leu Asp Gly Lys Gln Asn 
145                 150                 155                 160 


Thr Val Pro Leu Glu Thr Val Lys Thr Asn Lys Lys Asn Val Thr Val 
                165                 170                 175     


Gln Glu Leu Asp Leu Gln Ala Arg Arg Tyr Leu Gln Glu Lys Tyr Asn 
            180                 185                 190         


Leu Tyr Asn Ser Asp Val Phe Asp Gly Lys Val Gln Arg Gly Leu Ile 
        195                 200                 205             


Val Phe His Thr Ser Thr Glu Pro Ser Val Asn Tyr Asp Leu Phe Gly 
    210                 215                 220                 


Ala Gln Gly Gln Tyr Ser Asn Thr Leu Leu Arg Ile Tyr Arg Asp Asn 
225                 230                 235                 240 


Lys Thr Ile Asn Ser Glu Asn Met His Ile Asp Ile Tyr Leu Tyr Thr 
                245                 250                 255     


Ser 
    


<210>  5
<211>  266
<212>  PRT
<213>  Staphylococcus aureus

<400>  5

Met Tyr Lys Arg Leu Phe Ile Ser His Val Ile Leu Ile Phe Ala Leu 
1               5                   10                  15      


Ile Leu Val Ile Ser Thr Pro Asn Val Leu Ala Glu Ser Gln Pro Asp 
            20                  25                  30          


Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys Phe Thr Gly Leu Met 
        35                  40                  45              


Glu Asn Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala Ile Asn 
    50                  55                  60                  


Val Lys Ser Ile Asp Gln Phe Leu Tyr Phe Asp Leu Ile Tyr Ser Ile 
65                  70                  75                  80  


Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu Phe Lys 
                85                  90                  95      


Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp Val Phe 
            100                 105                 110         


Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr Asn Asp 
        115                 120                 125             


Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr Gly Gly 
    130                 135                 140                 


Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser Ile Thr 
145                 150                 155                 160 


Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp Val Gln 
                165                 170                 175     


Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu Thr Arg 
            180                 185                 190         


His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn Ser Pro 
        195                 200                 205             


Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser Phe Trp 
    210                 215                 220                 


Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser Lys Tyr 
225                 230                 235                 240 


Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp Val Lys 
                245                 250                 255     


Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
            260                 265     


<210>  6
<211>  266
<212>  PRT
<213>  Staphylococcus aureus

<400>  6

Met Asn Lys Ser Arg Phe Ile Ser Cys Val Ile Leu Ile Phe Ala Leu 
1               5                   10                  15      


Ile Leu Val Leu Phe Thr Pro Asn Val Leu Ala Glu Ser Gln Pro Asp 
            20                  25                  30          


Pro Thr Pro Asp Glu Leu His Lys Ala Ser Lys Phe Thr Gly Leu Met 
        35                  40                  45              


Glu Asn Met Lys Val Leu Tyr Asp Asp His Tyr Val Ser Ala Thr Lys 
    50                  55                  60                  


Val Lys Ser Val Asp Lys Phe Leu Ala His Asp Leu Ile Tyr Asn Ile 
65                  70                  75                  80  


Ser Asp Lys Lys Leu Lys Asn Tyr Asp Lys Val Lys Thr Glu Leu Leu 
                85                  90                  95      


Asn Glu Gly Leu Ala Lys Lys Tyr Lys Asp Glu Val Val Asp Val Tyr 
            100                 105                 110         


Gly Ser Asn Tyr Tyr Val Asn Cys Tyr Phe Ser Ser Lys Asp Asn Val 
        115                 120                 125             


Gly Lys Val Thr Gly Gly Lys Thr Cys Met Tyr Gly Gly Ile Thr Lys 
    130                 135                 140                 


His Glu Gly Asn His Phe Asp Asn Gly Asn Leu Gln Asn Val Leu Ile 
145                 150                 155                 160 


Arg Val Tyr Glu Asn Lys Arg Asn Thr Ile Ser Phe Glu Val Gln Thr 
                165                 170                 175     


Asp Lys Lys Ser Val Thr Ala Gln Glu Leu Asp Ile Lys Ala Arg Asn 
            180                 185                 190         


Phe Leu Ile Asn Lys Lys Asn Leu Tyr Glu Phe Asn Ser Ser Pro Tyr 
        195                 200                 205             


Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Asn Gly Asn Thr Phe Trp 
    210                 215                 220                 


Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser Lys Tyr 
225                 230                 235                 240 


Leu Met Met Tyr Asn Asp Asn Lys Thr Val Asp Ser Lys Ser Val Lys 
                245                 250                 255     


Ile Glu Val His Leu Thr Thr Lys Asn Gly 
            260                 265     


<210>  7
<211>  227
<212>  PRT
<213>  Staphylococcus aureus

<400>  7

Glu Ser Gln Pro Asp Pro Thr Pro Asp Glu Leu His Lys Ser Ser Glu 
1               5                   10                  15      


Phe Thr Gly Thr Met Gly Asn Met Lys Tyr Leu Tyr Asp Asp His Tyr 
            20                  25                  30          


Val Ser Ala Thr Lys Val Met Ser Val Asp Lys Phe Leu Ala His Asp 
        35                  40                  45              


Leu Ile Tyr Asn Ile Ser Asp Lys Lys Leu Lys Asn Tyr Asp Lys Val 
    50                  55                  60                  


Lys Thr Glu Leu Leu Asn Glu Asp Leu Ala Lys Lys Tyr Lys Asp Glu 
65                  70                  75                  80  


Val Val Asp Val Tyr Gly Ser Asn Tyr Tyr Val Asn Cys Tyr Phe Ser 
                85                  90                  95      


Ser Lys Asp Asn Val Gly Lys Val Thr Gly Gly Lys Thr Cys Met Tyr 
            100                 105                 110         


Gly Gly Ile Thr Lys His Glu Gly Asn His Phe Asp Asn Gly Asn Leu 
        115                 120                 125             


Gln Asn Val Leu Ile Arg Val Tyr Glu Asn Lys Arg Asn Thr Ile Ser 
    130                 135                 140                 


Phe Glu Val Gln Thr Asp Lys Lys Ser Val Thr Ala Gln Glu Leu Asp 
145                 150                 155                 160 


Ile Lys Ala Arg Asn Phe Leu Ile Asn Lys Lys Asn Leu Tyr Glu Phe 
                165                 170                 175     


Asn Ser Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Asn 
            180                 185                 190         


Gly Asn Thr Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe 
        195                 200                 205             


Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Thr Val Asp 
    210                 215                 220                 


Ser Lys Ser 
225         


<210>  8
<211>  226
<212>  PRT
<213>  Staphylococcus aureus

<400>  8

Ser Ser Glu Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp 
1               5                   10                  15      


Asp His Tyr Val Ser Ala Thr Lys Val Met Ser Val Asp Lys Phe Leu 
            20                  25                  30          


Ala His Asp Leu Ile Tyr Asn Ile Ser Asp Lys Lys Leu Lys Asn Tyr 
        35                  40                  45              


Asp Lys Val Lys Thr Glu Leu Leu Asn Glu Asp Leu Ala Lys Lys Tyr 
    50                  55                  60                  


Lys Asp Glu Val Val Asp Val Tyr Gly Ser Asn Tyr Tyr Val Asn Cys 
65                  70                  75                  80  


Tyr Phe Ser Ser Lys Asp Asn Val Gly Lys Val Thr Gly Gly Lys Thr 
                85                  90                  95      


Cys Met Tyr Gly Gly Ile Thr Lys Tyr Glu Gly Asn His Phe Asp Asn 
            100                 105                 110         


Gly Asn Leu Gln Asn Val Leu Ile Arg Val Tyr Glu Asn Lys Arg Asn 
        115                 120                 125             


Thr Ile Ser Phe Glu Val Gln Thr Asp Lys Lys Ser Val Thr Ala Gln 
    130                 135                 140                 


Glu Leu Asp Ile Lys Ala Arg Asn Phe Leu Ile Asn Lys Lys Asn Leu 
145                 150                 155                 160 


Tyr Glu Phe Asn Ser Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile 
                165                 170                 175     


Glu Asn Asn Gly Asn Thr Phe Trp Tyr Asp Met Met Pro Ala Pro Gly 
            180                 185                 190         


Asp Lys Phe Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys 
        195                 200                 205             


Thr Val Asp Ser Lys Ser Val Lys Ile Glu Val His Leu Thr Thr Lys 
    210                 215                 220                 


Asn Gly 
225     


<210>  9
<211>  258
<212>  PRT
<213>  Staphylococcus aureus

<400>  9

Met Lys Lys Phe Asn Ile Leu Ile Ala Leu Leu Phe Phe Thr Ser Leu 
1               5                   10                  15      


Val Ile Ser Pro Leu Asn Val Lys Ala Asn Glu Asn Ile Asp Ser Val 
            20                  25                  30          


Lys Glu Lys Glu Leu His Lys Lys Ser Glu Leu Ser Ser Thr Ala Leu 
        35                  40                  45              


Asn Asn Met Lys His Ser Tyr Ala Asp Lys Asn Pro Ile Ile Gly Glu 
    50                  55                  60                  


Asn Lys Ser Thr Gly Asp Gln Phe Leu Glu Asn Thr Leu Leu Tyr Lys 
65                  70                  75                  80  


Lys Phe Phe Thr Asp Leu Ile Asn Phe Glu Asp Leu Leu Ile Asn Phe 
                85                  90                  95      


Asn Ser Lys Glu Met Ala Gln His Phe Lys Ser Lys Asn Val Asp Val 
            100                 105                 110         


Tyr Pro Ile Arg Tyr Ser Ile Asn Cys Tyr Gly Gly Glu Ile Asp Arg 
        115                 120                 125             


Thr Ala Cys Thr Tyr Gly Gly Val Thr Pro His Glu Gly Asn Lys Leu 
    130                 135                 140                 


Lys Glu Arg Lys Lys Ile Pro Ile Asn Leu Trp Ile Asn Gly Val Gln 
145                 150                 155                 160 


Lys Glu Val Ser Leu Asp Lys Val Gln Thr Asp Lys Lys Asn Val Thr 
                165                 170                 175     


Val Gln Glu Leu Asp Ala Gln Ala Arg Arg Tyr Leu Gln Lys Asp Leu 
            180                 185                 190         


Lys Leu Tyr Asn Asn Asp Thr Leu Gly Gly Lys Ile Gln Arg Gly Lys 
        195                 200                 205             


Ile Glu Phe Asp Ser Ser Asp Gly Ser Lys Val Ser Tyr Asp Leu Phe 
    210                 215                 220                 


Asp Val Lys Gly Asp Phe Pro Glu Lys Gln Leu Arg Ile Tyr Ser Asp 
225                 230                 235                 240 


Asn Lys Thr Leu Ser Thr Glu His Leu His Ile Asp Ile Tyr Leu Tyr 
                245                 250                 255     


Glu Lys 
        


<210>  10
<211>  257
<212>  PRT
<213>  Staphylococcus aureus

<400>  10

Met Lys Lys Thr Ala Phe Ile Leu Leu Leu Phe Ile Ala Leu Thr Leu 
1               5                   10                  15      


Thr Thr Ser Pro Leu Val Asn Gly Ser Glu Lys Ser Glu Glu Ile Asn 
            20                  25                  30          


Glu Lys Asp Leu Arg Lys Lys Ser Glu Leu Gln Arg Asn Ala Leu Ser 
        35                  40                  45              


Asn Leu Arg Gln Ile Tyr Tyr Tyr Asn Glu Lys Ala Ile Thr Glu Asn 
    50                  55                  60                  


Lys Glu Ser Asp Asp Gln Phe Leu Glu Asn Thr Leu Leu Phe Lys Gly 
65                  70                  75                  80  


Phe Phe Thr Gly His Pro Trp Tyr Asn Asp Leu Leu Val Asp Leu Gly 
                85                  90                  95      


Ser Lys Asp Ala Thr Asn Lys Tyr Lys Gly Lys Lys Val Asp Leu Tyr 
            100                 105                 110         


Gly Ala Tyr Tyr Gly Tyr Gln Cys Ala Gly Gly Thr Pro Asn Lys Thr 
        115                 120                 125             


Ala Cys Met Tyr Gly Gly Val Thr Leu His Asp Asn Asn Arg Leu Thr 
    130                 135                 140                 


Glu Glu Lys Lys Val Pro Ile Asn Leu Trp Ile Asp Gly Lys Gln Thr 
145                 150                 155                 160 


Thr Val Pro Ile Asp Lys Val Lys Thr Ser Lys Lys Glu Val Thr Val 
                165                 170                 175     


Gln Glu Leu Asp Leu Gln Ala Arg His Tyr Leu His Gly Lys Phe Gly 
            180                 185                 190         


Leu Tyr Asn Ser Asp Ser Phe Gly Gly Lys Val Gln Arg Gly Leu Ile 
        195                 200                 205             


Val Phe His Ser Ser Glu Gly Ser Thr Val Ser Tyr Asp Leu Phe Asp 
    210                 215                 220                 


Ala Gln Gly Gln Tyr Pro Asp Thr Leu Leu Arg Ile Tyr Arg Asp Asn 
225                 230                 235                 240 


Lys Thr Ile Asn Ser Glu Asn Leu His Ile Asp Leu Tyr Leu Tyr Thr 
                245                 250                 255     


Thr 
    


<210>  11
<211>  258
<212>  PRT
<213>  Staphylococcus aureus

<400>  11

Met Lys Lys Leu Ser Thr Val Ile Ile Ile Leu Ile Leu Glu Ile Val 
1               5                   10                  15      


Phe His Asn Met Asn Tyr Val Asn Ala Gln Pro Asp Pro Lys Leu Asp 
            20                  25                  30          


Glu Leu Asn Lys Val Ser Asp Tyr Lys Asn Asn Lys Gly Thr Met Gly 
        35                  40                  45              


Asn Val Met Asn Leu Tyr Thr Ser Pro Pro Val Glu Gly Arg Gly Val 
    50                  55                  60                  


Ile Asn Ser Arg Gln Phe Leu Ser His Asp Leu Ile Phe Pro Ile Glu 
65                  70                  75                  80  


Tyr Lys Ser Tyr Asn Glu Val Lys Thr Glu Leu Glu Asn Thr Glu Leu 
                85                  90                  95      


Ala Asn Asn Tyr Lys Asp Lys Lys Val Asp Ile Phe Gly Val Pro Tyr 
            100                 105                 110         


Phe Tyr Thr Cys Ile Ile Pro Lys Ser Glu Pro Asp Ile Asn Gln Asn 
        115                 120                 125             


Phe Gly Gly Cys Cys Met Tyr Gly Gly Leu Thr Phe Asn Ser Ser Glu 
    130                 135                 140                 


Asn Glu Arg Asp Lys Leu Ile Thr Val Gln Val Thr Ile Asp Asn Arg 
145                 150                 155                 160 


Gln Ser Leu Gly Phe Thr Ile Thr Thr Asn Lys Asn Met Val Thr Ile 
                165                 170                 175     


Gln Glu Leu Asp Tyr Lys Ala Arg His Trp Leu Thr Lys Glu Lys Lys 
            180                 185                 190         


Leu Tyr Glu Phe Asp Gly Ser Ala Phe Glu Ser Gly Tyr Ile Lys Phe 
        195                 200                 205             


Thr Glu Lys Asn Asn Thr Ser Phe Trp Phe Asp Leu Phe Pro Lys Lys 
    210                 215                 220                 


Glu Leu Val Pro Phe Val Pro Tyr Lys Phe Leu Asn Ile Tyr Gly Asp 
225                 230                 235                 240 


Asn Lys Val Val Asp Ser Lys Ser Ile Lys Met Glu Val Phe Leu Asn 
                245                 250                 255     


Thr His 
        


<210>  12
<211>  241
<212>  PRT
<213>  Staphylococcus aureus

<400>  12

Met Ile Asn Lys Ile Lys Ile Leu Phe Ser Phe Leu Ala Leu Leu Leu 
1               5                   10                  15      


Ser Phe Thr Ser Tyr Ala Lys Ala Glu Asp Leu His Asp Lys Ser Glu 
            20                  25                  30          


Leu Thr Asp Leu Ala Leu Ala Asn Ala Tyr Gly Gln Tyr Asn His Pro 
        35                  40                  45              


Phe Ile Lys Glu Asn Ile Lys Ser Asp Glu Ile Ser Gly Glu Lys Asp 
    50                  55                  60                  


Leu Ile Phe Arg Asn Gln Gly Asp Ser Gly Asn Asp Leu Arg Val Lys 
65                  70                  75                  80  


Phe Ala Thr Ala Asp Leu Ala Gln Lys Phe Lys Asn Lys Asn Val Asp 
                85                  90                  95      


Ile Tyr Gly Ala Ser Phe Tyr Tyr Lys Cys Glu Lys Ile Ser Glu Asn 
            100                 105                 110         


Ile Ser Glu Cys Leu Tyr Gly Gly Thr Thr Leu Asn Ser Glu Lys Leu 
        115                 120                 125             


Ala Gln Glu Arg Val Ile Gly Ala Asn Val Trp Val Asp Gly Ile Gln 
    130                 135                 140                 


Lys Glu Thr Glu Leu Ile Arg Thr Asn Lys Lys Asn Val Thr Leu Gln 
145                 150                 155                 160 


Glu Leu Asp Ile Lys Ile Arg Lys Ile Leu Ser Asp Lys Tyr Lys Ile 
                165                 170                 175     


Tyr Tyr Lys Asp Ser Glu Ile Ser Lys Gly Leu Ile Glu Phe Asp Met 
            180                 185                 190         


Lys Thr Pro Arg Asp Tyr Ser Phe Asp Ile Tyr Asp Leu Lys Gly Glu 
        195                 200                 205             


Asn Asp Tyr Glu Ile Asp Lys Ile Tyr Glu Asp Asn Lys Thr Leu Lys 
    210                 215                 220                 


Ser Asp Asp Ile Ser His Ile Asp Val Asn Leu Tyr Thr Lys Lys Lys 
225                 230                 235                 240 


Val 
    


<210>  13
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gln Lys Leu Gln Leu Cys Val Tyr Ile Tyr Leu Phe Met Leu Ile 
1               5                   10                  15      


Val Ala Gly Pro Val Asp Leu Asn Glu Asn Ser Glu Gln Lys Glu Asn 
            20                  25                  30          


Val Glu Lys Glu Gly Leu Cys Asn Ala Cys Thr Trp Arg Gln Asn Thr 
        35                  40                  45              


Lys Ser Ser Arg Ile Glu Ala Ile Lys Ile Gln Ile Leu Ser Lys Leu 
    50                  55                  60                  


Arg Leu Glu Thr Ala Pro Asn Ile Ser Lys Asp Val Ile Arg Gln Leu 
65                  70                  75                  80  


Leu Pro Lys Ala Pro Pro Leu Arg Glu Leu Ile Asp Gln Tyr Asp Val 
                85                  90                  95      


Gln Arg Asp Asp Ser Ser Asp Gly Ser Leu Glu Asp Asp Asp Tyr His 
            100                 105                 110         


Ala Thr Thr Glu Thr Ile Ile Thr Met Pro Thr Glu Ser Asp Phe Leu 
        115                 120                 125             


Met Gln Val Asp Gly Lys Pro Lys Cys Cys Phe Phe Lys Phe Ser Ser 
    130                 135                 140                 


Lys Ile Gln Tyr Asn Lys Val Val Lys Ala Gln Leu Trp Ile Tyr Leu 
145                 150                 155                 160 


Arg Pro Val Glu Thr Pro Thr Thr Val Phe Val Gln Ile Leu Arg Leu 
                165                 170                 175     


Ile Lys Pro Met Lys Asp Gly Thr Arg Tyr Thr Gly Ile Arg Ser Leu 
            180                 185                 190         


Lys Leu Asp Met Asn Pro Gly Thr Gly Ile Trp Gln Ser Ile Asp Val 
        195                 200                 205             


Lys Thr Val Leu Gln Asn Trp Leu Lys Gln Pro Glu Ser Asn Leu Gly 
    210                 215                 220                 


Ile Glu Ile Lys Ala Leu Asp Glu Asn Gly His Asp Leu Ala Val Thr 
225                 230                 235                 240 


Phe Pro Gly Pro Gly Glu Asp Gly Leu Asn Pro Phe Leu Glu Val Lys 
                245                 250                 255     


Val Thr Asp Thr Pro Lys Arg Ser Arg Arg Asp Phe Gly Leu Asp Cys 
            260                 265                 270         


Asp Glu His Ser Thr Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 
        275                 280                 285             


Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
    290                 295                 300                 


Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu Phe Val Phe Leu Gln Lys 
305                 310                 315                 320 


Tyr Pro His Thr His Leu Val His Gln Ala Asn Pro Arg Gly Ser Ala 
                325                 330                 335     


Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 
            340                 345                 350         


Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly Lys Ile Pro Ala Met Val 
        355                 360                 365             


Val Asp Arg Cys Gly Cys Ser 
    370                 375 


<210>  14
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys 
1               5                   10                  15  


<210>  15
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Val Arg Ala Arg His Gln Pro Gly Gly Leu Cys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Cys Gln Phe Met Glu Asp Arg Ser Ala Gln Ala Gly Asn Cys 
            20                  25                  30          


Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu Tyr Lys Thr 
        35                  40                  45              


Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu Ser Thr Ser 
    50                  55                  60                  


Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys Trp Met Ile 
65                  70                  75                  80  


Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu Thr Cys Glu 
                85                  90                  95      


Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn Lys Lys Asn 
            100                 105                 110         


Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile Thr Trp Lys 
        115                 120                 125             


Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn Glu Cys Ala 
    130                 135                 140                 


Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu Val Gln Tyr 
145                 150                 155                 160 


Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys Pro Gly Ser 
                165                 170                 175     


Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys Val Thr Cys 
            180                 185                 190         


Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr Leu Cys Gly 
        195                 200                 205             


Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg Lys Ala Thr 
    210                 215                 220                 


Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly Lys Cys Ile 
225                 230                 235                 240 


Lys Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys 
                245                 250                 255     


Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu 
            260                 265                 270         


Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn 
        275                 280                 285             


Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser 
    290                 295                 300                 


Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn Ser Ile Ser 
305                 310                 315                 320 


Glu Asp Thr Glu Glu Glu Glu Glu Asp Glu Asp Gln Asp Tyr Ser Phe 
                325                 330                 335     


Pro Ile Ser Ser Ile Leu Glu Trp 
            340                 


<210>  16
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Asn Cys Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu 
1               5                   10                  15      


Tyr Lys Thr Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu 
            20                  25                  30          


Ser Thr Ser Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys 
        35                  40                  45              


Trp Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu 
    50                  55                  60                  


Thr Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn 
65                  70                  75                  80  


Lys Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile 
                85                  90                  95      


Thr Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn 
            100                 105                 110         


Glu Cys Ala Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu 
        115                 120                 125             


Val Gln Tyr Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys 
    130                 135                 140                 


Pro Gly Ser Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys 
145                 150                 155                 160 


Val Thr Cys Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr 
                165                 170                 175     


Leu Cys Gly Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg 
            180                 185                 190         


Lys Ala Thr Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly 
        195                 200                 205             


Lys Cys Ile Lys Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly 
    210                 215                 220                 


Lys Lys Cys Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu 
225                 230                 235                 240 


Cys Asp Glu Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala 
                245                 250                 255     


Ser Asp Asn Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala 
            260                 265                 270         


Cys Ser Ser Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn 
        275                 280                 285             


<210>  17
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  含SEC2片段与肌生成抑制素片段的组合物。

<400>  17

Ser Ser Glu Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp 
1               5                   10                  15      


Asp His Tyr Val Ser Ala Thr Lys Val Met Ser Val Asp Lys Phe Leu 
            20                  25                  30          


Ala His Asp Leu Ile Tyr Asn Ile Ser Asp Lys Lys Leu Lys Asn Tyr 
        35                  40                  45              


Asp Lys Val Lys Thr Glu Leu Leu Asn Glu Asp Leu Ala Lys Lys Tyr 
    50                  55                  60                  


Lys Asp Glu Val Val Asp Val Tyr Gly Ser Asn Tyr Tyr Val Asn Cys 
65                  70                  75                  80  


Tyr Phe Ser Ser Lys Asp Asn Val Gly Lys Val Thr Gly Gly Lys Thr 
                85                  90                  95      


Cys Met Tyr Gly Gly Ile Thr Lys Tyr Glu Gly Asn His Phe Asp Asn 
            100                 105                 110         


Gly Asn Leu Gln Asn Val Leu Ile Arg Val Tyr Glu Asn Lys Arg Asn 
        115                 120                 125             


Thr Ile Ser Phe Glu Val Gln Thr Asp Lys Lys Ser Val Thr Ala Gln 
    130                 135                 140                 


Glu Leu Asp Ile Lys Ala Arg Asn Phe Leu Ile Asn Lys Lys Asn Leu 
145                 150                 155                 160 


Tyr Glu Phe Asn Ser Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile 
                165                 170                 175     


Glu Asn Asn Gly Asn Thr Phe Trp Tyr Asp Met Met Pro Ala Pro Gly 
            180                 185                 190         


Asp Lys Phe Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys 
        195                 200                 205             


Thr Val Asp Ser Lys Ser Val Lys Ile Glu Val His Leu Thr Thr Lys 
    210                 215                 220                 


Asn Gly Leu Glu Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu 
225                 230                 235                 240 


Ser Arg Cys Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser 
                245                 250                 255     


Arg Cys Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg 
            260                 265                 270         


Cys Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys 
        275                 280                 285             


Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys Asp 
    290                 295                 300                 


Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys 
305                 310                 315             


