б


<110>  ݷ
 
<120>  ԼȫＰҽҩ;

<130>  cfp0542

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  678
<212>  DNA
<213>  Staphylococcus aureus

<400>  1
tcaagtgagt ttactggtct gatggagaat atgaaagttt tatatgatga tcattatgta       60

tcagcaacta aagttatgtc tgtagataaa tttttggcac atgatttaat ttataacatt      120

agtgataaaa aactaaaaaa ttatgacaaa gtgaaaacag agttattaaa tgaagattta      180

gcaaagaagt acaaagatga agtagttgat gtgtatggat caaattacta tgtaaactgc      240

tatttttcat ccaaagataa tgtaggtaaa gttacaggtg gtaaaacttg tatgtatgga      300

ggaataacaa aatatgaagg aaaccacttt gataatggga acttacaaaa tgtacttata      360

agagtttatg aaaataaaag aaacacaatt tcttttgaag tgcaaactga taagaaaagt      420

gtaacagctc aagaactaga cataaaagct aggaattttt taattaataa aaaaaatttg      480

tatgagttta acagttcacc atatgaaaca ggatatataa aatttattga aaataacggc      540

aatacttttt ggtatgatat gatgcctgca ccaggcgata agtttgacca atctaaatat      600

ttaatgatgt acaacgacaa taaaacggtt gattctaaaa gtgtgaagat agaagtccac      660

cttacaacaa agaatgga                                                    678


<210>  2
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  2
gattttggac tcgactgtga tgagcactca acagaatctc gatgc                       45


<210>  3
<211>  954
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEC2mƬ뼡Ƭ֮

<400>  3
tcaagtgagt ttactggtct gatggagaat atgaaagttt tatatgatga tcattatgta       60

tcagcaacta aagttatgtc tgtagataaa tttttggcac atgatttaat ttataacatt      120

agtgataaaa aactaaaaaa ttatgacaaa gtgaaaacag agttattaaa tgaagattta      180

gcaaagaagt acaaagatga agtagttgat gtgtatggat caaattacta tgtaaactgc      240

tatttttcat ccaaagataa tgtaggtaaa gttacaggtg gtaaaacttg tatgtatgga      300

ggaataacaa aatatgaagg aaaccacttt gataatggga acttacaaaa tgtacttata      360

agagtttatg aaaataaaag aaacacaatt tcttttgaag tgcaaactga taagaaaagt      420

gtaacagctc aagaactaga cataaaagct aggaattttt taattaataa aaaaaatttg      480

tatgagttta acagttcacc atatgaaaca ggatatataa aatttattga aaataacggc      540

aatacttttt ggtatgatat gatgcctgca ccaggcgata agtttgacca atctaaatat      600

ttaatgatgt acaacgacaa taaaacggtt gattctaaaa gtgtgaagat agaagtccac      660

cttacaacaa agaatggact cgaggatttt ggactcgact gtgatgagca ctcaacagaa      720

tctcgatgcg attttggact cgactgtgat gagcactcaa cagaatctcg atgcgatttt      780

ggactcgact gtgatgagca ctcaacagaa tctcgatgcg attttggact cgactgtgat      840

gagcactcaa cagaatctcg atgcgatttt ggactcgact gtgatgagca ctcaacagaa      900

tctcgatgcg attttggact cgactgtgat gagcactcaa cagaatctcg atgc            954


<210>  4
<211>  257
<212>  PRT
<213>  Staphylococcus aureus

<400>  4

Met Lys Lys Thr Ala Phe Thr Leu Leu Leu Phe Ile Ala Leu Thr Leu 
1                            5                                10                               15      


Thr Thr Ser Pro Leu Val Asn Gly Ser Glu Lys Ser Glu Glu Ile Asn 
                     20                              25                              30          


Glu Lys Asp Leu Arg Lys Lys Ser Glu Leu Gln Gly Thr Ala Leu Gly 
               35                                40                              45              


Asn Leu Lys Gln Ile Tyr Tyr Tyr Asn Glu Lys Ala Lys Thr Glu Asn 
         50                             55                               60                            


Lys Glu Ser His Asp Gln Phe Leu Gln His Thr Ile Leu Phe Lys Gly 
65                               70                               75                             80  


Phe Phe Thr Asp His Ser Trp Tyr Asn Asp Leu Leu Val Asp Phe Asp 
                             85                               90                               95      


Ser Lys Asp Ile Val Asp Lys Tyr Lys Gly Lys Lys Val Asp Leu Tyr 
                   100                              105                            110         


Gly Ala Tyr Tyr Gly Tyr Gln Cys Ala Gly Gly Thr Pro Asn Lys Thr 
              115                           120                             125             


Ala Cys Met Tyr Gly Gly Val Thr Leu His Asp Asn Asn Arg Leu Thr 
       130                             135                            140                 


Glu Glu Lys Lys Val Pro Ile Asn Leu Trp Leu Asp Gly Lys Gln Asn 
145                            150                            155                              160 


Thr Val Pro Leu Glu Thr Val Lys Thr Asn Lys Lys Asn Val Thr Val 
                           165                             170                             175     


Gln Glu Leu Asp Leu Gln Ala Arg Arg Tyr Leu Gln Glu Lys Tyr Asn 
                     180                              185                             190         


Leu Tyr Asn Ser Asp Val Phe Asp Gly Lys Val Gln Arg Gly Leu Ile 
              195                             200                              205             


Val Phe His Thr Ser Thr Glu Pro Ser Val Asn Tyr Asp Leu Phe Gly 
       210                           215                            220                 


Ala Gln Gly Gln Tyr Ser Asn Thr Leu Leu Arg Ile Tyr Arg Asp Asn 
225                            230                              235                            240 


Lys Thr Ile Asn Ser Glu Asn Met His Ile Asp Ile Tyr Leu Tyr Thr 
                          245                             250                          255     


Ser 
    


<210>  5
<211>  266
<212>  PRT
<213>  Staphylococcus aureus

<400>  5

Met Tyr Lys Arg Leu Phe Ile Ser His Val Ile Leu Ile Phe Ala Leu 
1                             5                             10                           15      


Ile Leu Val Ile Ser Thr Pro Asn Val Leu Ala Glu Ser Gln Pro Asp 
                   20                              25                             30          


Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys Phe Thr Gly Leu Met 
              35                                40                             45              


Glu Asn Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala Ile Asn 
        50                                55                               60                  


Val Lys Ser Ile Asp Gln Phe Leu Tyr Phe Asp Leu Ile Tyr Ser Ile 
65                             70                               75                             80  


Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu Phe Lys 
                             85                                 90                              95      


Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp Val Phe 
                      100                             105                              110         


Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr Asn Asp 
              115                            120                             125             


Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr Gly Gly 
     130                            135                              140                 


Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser Ile Thr 
145                            150                               155                          160 


Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp Val Gln 
                            165                              170                             175     


Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu Thr Arg 
                     180                             185                             190         


His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn Ser Pro 
             195                             200                              205             


Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser Phe Trp 
       210                           215                           220                 


Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser Lys Tyr 
225                              230                             235                            240 


Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp Val Lys 
                             245                               250                             255     


Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
                   260                            265     


<210>  6
<211>  266
<212>  PRT
<213>  Staphylococcus aureus

<400>  6

Met Asn Lys Ser Arg Phe Ile Ser Cys Val Ile Leu Ile Phe Ala Leu 
1                           5                               10                           15      


Ile Leu Val Leu Phe Thr Pro Asn Val Leu Ala Glu Ser Gln Pro Asp 
                    20                               25                              30          


Pro Thr Pro Asp Glu Leu His Lys Ala Ser Lys Phe Thr Gly Leu Met 
              35                               40                              45              


Glu Asn Met Lys Val Leu Tyr Asp Asp His Tyr Val Ser Ala Thr Lys 
        50                               55                                60                  


Val Lys Ser Val Asp Lys Phe Leu Ala His Asp Leu Ile Tyr Asn Ile 
65                               70                               75                             80  


Ser Asp Lys Lys Leu Lys Asn Tyr Asp Lys Val Lys Thr Glu Leu Leu 
                             85                                90                               95      


Asn Glu Gly Leu Ala Lys Lys Tyr Lys Asp Glu Val Val Asp Val Tyr 
                      100                            105                              110         


Gly Ser Asn Tyr Tyr Val Asn Cys Tyr Phe Ser Ser Lys Asp Asn Val 
             115                             120                            125             


Gly Lys Val Thr Gly Gly Lys Thr Cys Met Tyr Gly Gly Ile Thr Lys 
       130                            135                             140                 


His Glu Gly Asn His Phe Asp Asn Gly Asn Leu Gln Asn Val Leu Ile 
145                            150                               155                             160 


Arg Val Tyr Glu Asn Lys Arg Asn Thr Ile Ser Phe Glu Val Gln Thr 
                            165                             170                           175     


Asp Lys Lys Ser Val Thr Ala Gln Glu Leu Asp Ile Lys Ala Arg Asn 
                     180                            185                            190         


Phe Leu Ile Asn Lys Lys Asn Leu Tyr Glu Phe Asn Ser Ser Pro Tyr 
              195                            200                              205             


Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Asn Gly Asn Thr Phe Trp 
       210                           215                            220                 


Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser Lys Tyr 
225                              230                             235                            240 


Leu Met Met Tyr Asn Asp Asn Lys Thr Val Asp Ser Lys Ser Val Lys 
                             245                              250                            255     


Ile Glu Val His Leu Thr Thr Lys Asn Gly 
                   260                             265     


<210>  7
<211>  227
<212>  PRT
<213>  Staphylococcus aureus

<400>  7

Glu Ser Gln Pro Asp Pro Thr Pro Asp Glu Leu His Lys Ser Ser Glu 
1                            5                              10                               15      


Phe Thr Gly Thr Met Gly Asn Met Lys Tyr Leu Tyr Asp Asp His Tyr 
                     20                                 25                               30          


Val Ser Ala Thr Lys Val Met Ser Val Asp Lys Phe Leu Ala His Asp 
             35                                40                               45              


Leu Ile Tyr Asn Ile Ser Asp Lys Lys Leu Lys Asn Tyr Asp Lys Val 
       50                            55                                60                  


Lys Thr Glu Leu Leu Asn Glu Asp Leu Ala Lys Lys Tyr Lys Asp Glu 
65                                 70                               75                               80  


Val Val Asp Val Tyr Gly Ser Asn Tyr Tyr Val Asn Cys Tyr Phe Ser 
                             85                              90                               95      


Ser Lys Asp Asn Val Gly Lys Val Thr Gly Gly Lys Thr Cys Met Tyr 
                     100                            105                             110         


Gly Gly Ile Thr Lys His Glu Gly Asn His Phe Asp Asn Gly Asn Leu 
             115                           120                              125             


Gln Asn Val Leu Ile Arg Val Tyr Glu Asn Lys Arg Asn Thr Ile Ser 
      130                             135                              140                 


Phe Glu Val Gln Thr Asp Lys Lys Ser Val Thr Ala Gln Glu Leu Asp 
145                            150                             155                             160 


Ile Lys Ala Arg Asn Phe Leu Ile Asn Lys Lys Asn Leu Tyr Glu Phe 
                           165                           170                              175     


Asn Ser Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Asn 
                   180                             185                         190         


Gly Asn Thr Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe 
               195                            200                             205             


Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Thr Val Asp 
        210                            215                               220                 


Ser Lys Ser 
225         


<210>  8
<211>  226
<212>  PRT
<213>  Staphylococcus aureus

<400>  8

Ser Ser Glu Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp 
1                           5                                10                                15      


Asp His Tyr Val Ser Ala Thr Lys Val Met Ser Val Asp Lys Phe Leu 
                      20                              25                              30          


Ala His Asp Leu Ile Tyr Asn Ile Ser Asp Lys Lys Leu Lys Asn Tyr 
              35                             40                              45              


Asp Lys Val Lys Thr Glu Leu Leu Asn Glu Asp Leu Ala Lys Lys Tyr 
        50                               55                                60                  


Lys Asp Glu Val Val Asp Val Tyr Gly Ser Asn Tyr Tyr Val Asn Cys 
65                                70                               75                              80  


Tyr Phe Ser Ser Lys Asp Asn Val Gly Lys Val Thr Gly Gly Lys Thr 
                           85                                 90                             95      


Cys Met Tyr Gly Gly Ile Thr Lys Tyr Glu Gly Asn His Phe Asp Asn 
                     100                           105                             110         


Gly Asn Leu Gln Asn Val Leu Ile Arg Val Tyr Glu Asn Lys Arg Asn 
              115                             120                            125             


Thr Ile Ser Phe Glu Val Gln Thr Asp Lys Lys Ser Val Thr Ala Gln 
      130                           135                            140                 


Glu Leu Asp Ile Lys Ala Arg Asn Phe Leu Ile Asn Lys Lys Asn Leu 
145                            150                             155                            160 


Tyr Glu Phe Asn Ser Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile 
                            165                           170                           175     


Glu Asn Asn Gly Asn Thr Phe Trp Tyr Asp Met Met Pro Ala Pro Gly 
                     180                              185                              190         


Asp Lys Phe Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys 
              195                            200                                205             


Thr Val Asp Ser Lys Ser Val Lys Ile Glu Val His Leu Thr Thr Lys 
       210                            215                          220                 


Asn Gly 
225     


<210>  9
<211>  258
<212>  PRT
<213>  Staphylococcus aureus

<400>  9

Met Lys Lys Phe Asn Ile Leu Ile Ala Leu Leu Phe Phe Thr Ser Leu 
1                             5                             10                              15      


Val Ile Ser Pro Leu Asn Val Lys Ala Asn Glu Asn Ile Asp Ser Val 
                   20                               25                              30          


Lys Glu Lys Glu Leu His Lys Lys Ser Glu Leu Ser Ser Thr Ala Leu 
              35                                40                              45              


Asn Asn Met Lys His Ser Tyr Ala Asp Lys Asn Pro Ile Ile Gly Glu 
        50                               55                                60                  


Asn Lys Ser Thr Gly Asp Gln Phe Leu Glu Asn Thr Leu Leu Tyr Lys 
65                               70                                75                                80  


Lys Phe Phe Thr Asp Leu Ile Asn Phe Glu Asp Leu Leu Ile Asn Phe 
                             85                              90                              95      


Asn Ser Lys Glu Met Ala Gln His Phe Lys Ser Lys Asn Val Asp Val 
                    100                             105                             110         


Tyr Pro Ile Arg Tyr Ser Ile Asn Cys Tyr Gly Gly Glu Ile Asp Arg 
            115                          120                             125             


Thr Ala Cys Thr Tyr Gly Gly Val Thr Pro His Glu Gly Asn Lys Leu 
      130                             135                            140                 


Lys Glu Arg Lys Lys Ile Pro Ile Asn Leu Trp Ile Asn Gly Val Gln 
145                            150                           155                           160 


Lys Glu Val Ser Leu Asp Lys Val Gln Thr Asp Lys Lys Asn Val Thr 
                           165                             170                              175     


Val Gln Glu Leu Asp Ala Gln Ala Arg Arg Tyr Leu Gln Lys Asp Leu 
                     180                             185                             190         


Lys Leu Tyr Asn Asn Asp Thr Leu Gly Gly Lys Ile Gln Arg Gly Lys 
               195                             200                            205             


Ile Glu Phe Asp Ser Ser Asp Gly Ser Lys Val Ser Tyr Asp Leu Phe 
      210                           215                            220                 


Asp Val Lys Gly Asp Phe Pro Glu Lys Gln Leu Arg Ile Tyr Ser Asp 
225                              230                             235                          240 


Asn Lys Thr Leu Ser Thr Glu His Leu His Ile Asp Ile Tyr Leu Tyr 
                            245                            250                          255     


Glu Lys 
        


<210>  10
<211>  257
<212>  PRT
<213>  Staphylococcus aureus

<400>  10

Met Lys Lys Thr Ala Phe Ile Leu Leu Leu Phe Ile Ala Leu Thr Leu 
1                            5                              10                              15      


Thr Thr Ser Pro Leu Val Asn Gly Ser Glu Lys Ser Glu Glu Ile Asn 
                     20                               25                              30          


Glu Lys Asp Leu Arg Lys Lys Ser Glu Leu Gln Arg Asn Ala Leu Ser 
               35                                40                               45              


Asn Leu Arg Gln Ile Tyr Tyr Tyr Asn Glu Lys Ala Ile Thr Glu Asn 
        50                              55                               60                  


Lys Glu Ser Asp Asp Gln Phe Leu Glu Asn Thr Leu Leu Phe Lys Gly 
65                                70                                75                               80  


Phe Phe Thr Gly His Pro Trp Tyr Asn Asp Leu Leu Val Asp Leu Gly 
                            85                               90                                95      


Ser Lys Asp Ala Thr Asn Lys Tyr Lys Gly Lys Lys Val Asp Leu Tyr 
                    100                             105                             110         


Gly Ala Tyr Tyr Gly Tyr Gln Cys Ala Gly Gly Thr Pro Asn Lys Thr 
              115                            120                            125             


Ala Cys Met Tyr Gly Gly Val Thr Leu His Asp Asn Asn Arg Leu Thr 
       130                             135                             140                 


Glu Glu Lys Lys Val Pro Ile Asn Leu Trp Ile Asp Gly Lys Gln Thr 
145                            150                           155                            160 


Thr Val Pro Ile Asp Lys Val Lys Thr Ser Lys Lys Glu Val Thr Val 
                          165                            170                            175     


Gln Glu Leu Asp Leu Gln Ala Arg His Tyr Leu His Gly Lys Phe Gly 
                     180                             185                            190         


Leu Tyr Asn Ser Asp Ser Phe Gly Gly Lys Val Gln Arg Gly Leu Ile 
              195                            200                              205             


Val Phe His Ser Ser Glu Gly Ser Thr Val Ser Tyr Asp Leu Phe Asp 
      210                            215                           220                 


Ala Gln Gly Gln Tyr Pro Asp Thr Leu Leu Arg Ile Tyr Arg Asp Asn 
225                            230                              235                            240 


Lys Thr Ile Asn Ser Glu Asn Leu His Ile Asp Leu Tyr Leu Tyr Thr 
                          245                            250                             255     


Thr 
    


<210>  11
<211>  258
<212>  PRT
<213>  Staphylococcus aureus

<400>  11

Met Lys Lys Leu Ser Thr Val Ile Ile Ile Leu Ile Leu Glu Ile Val 
1                            5                           10                            15      


Phe His Asn Met Asn Tyr Val Asn Ala Gln Pro Asp Pro Lys Leu Asp 
                     20                                 25                              30          


Glu Leu Asn Lys Val Ser Asp Tyr Lys Asn Asn Lys Gly Thr Met Gly 
                35                              40                                45              


Asn Val Met Asn Leu Tyr Thr Ser Pro Pro Val Glu Gly Arg Gly Val 
        50                                55                             60                  


Ile Asn Ser Arg Gln Phe Leu Ser His Asp Leu Ile Phe Pro Ile Glu 
65                              70                               75                           80  


Tyr Lys Ser Tyr Asn Glu Val Lys Thr Glu Leu Glu Asn Thr Glu Leu 
                            85                               90                               95      


Ala Asn Asn Tyr Lys Asp Lys Lys Val Asp Ile Phe Gly Val Pro Tyr 
                      100                             105                           110         


Phe Tyr Thr Cys Ile Ile Pro Lys Ser Glu Pro Asp Ile Asn Gln Asn 
             115                         120                             125             


Phe Gly Gly Cys Cys Met Tyr Gly Gly Leu Thr Phe Asn Ser Ser Glu 
       130                              135                            140                 


Asn Glu Arg Asp Lys Leu Ile Thr Val Gln Val Thr Ile Asp Asn Arg 
145                              150                           155                           160 


Gln Ser Leu Gly Phe Thr Ile Thr Thr Asn Lys Asn Met Val Thr Ile 
                           165                           170                              175     


Gln Glu Leu Asp Tyr Lys Ala Arg His Trp Leu Thr Lys Glu Lys Lys 
                     180                             185                            190         


Leu Tyr Glu Phe Asp Gly Ser Ala Phe Glu Ser Gly Tyr Ile Lys Phe 
              195                            200                             205             


Thr Glu Lys Asn Asn Thr Ser Phe Trp Phe Asp Leu Phe Pro Lys Lys 
       210                             215                             220                 


Glu Leu Val Pro Phe Val Pro Tyr Lys Phe Leu Asn Ile Tyr Gly Asp 
225                             230                            235                           240 


Asn Lys Val Val Asp Ser Lys Ser Ile Lys Met Glu Val Phe Leu Asn 
                            245                          250                              255     


Thr His 
        


<210>  12
<211>  241
<212>  PRT
<213>  Staphylococcus aureus

<400>  12

Met Ile Asn Lys Ile Lys Ile Leu Phe Ser Phe Leu Ala Leu Leu Leu 
1                           5                             10                              15      


Ser Phe Thr Ser Tyr Ala Lys Ala Glu Asp Leu His Asp Lys Ser Glu 
                    20                              25                               30          


Leu Thr Asp Leu Ala Leu Ala Asn Ala Tyr Gly Gln Tyr Asn His Pro 
                35                               40                              45              


Phe Ile Lys Glu Asn Ile Lys Ser Asp Glu Ile Ser Gly Glu Lys Asp 
      50                              55                             60                  


Leu Ile Phe Arg Asn Gln Gly Asp Ser Gly Asn Asp Leu Arg Val Lys 
65                              70                                75                               80  


Phe Ala Thr Ala Asp Leu Ala Gln Lys Phe Lys Asn Lys Asn Val Asp 
                           85                                90                                95      


Ile Tyr Gly Ala Ser Phe Tyr Tyr Lys Cys Glu Lys Ile Ser Glu Asn 
                   100                            105                           110         


Ile Ser Glu Cys Leu Tyr Gly Gly Thr Thr Leu Asn Ser Glu Lys Leu 
           115                             120                              125             


Ala Gln Glu Arg Val Ile Gly Ala Asn Val Trp Val Asp Gly Ile Gln 
      130                           135                              140                 


Lys Glu Thr Glu Leu Ile Arg Thr Asn Lys Lys Asn Val Thr Leu Gln 
145                           150                              155                             160 


Glu Leu Asp Ile Lys Ile Arg Lys Ile Leu Ser Asp Lys Tyr Lys Ile 
                           165                          170                            175     


Tyr Tyr Lys Asp Ser Glu Ile Ser Lys Gly Leu Ile Glu Phe Asp Met 
                    180                           185                           190         


Lys Thr Pro Arg Asp Tyr Ser Phe Asp Ile Tyr Asp Leu Lys Gly Glu 
             195                             200                             205             


Asn Asp Tyr Glu Ile Asp Lys Ile Tyr Glu Asp Asn Lys Thr Leu Lys 
       210                            215                            220                 


Ser Asp Asp Ile Ser His Ile Asp Val Asn Leu Tyr Thr Lys Lys Lys 
225                          230                             235                            240 


Val 
    


<210>  13
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gln Lys Leu Gln Leu Cys Val Tyr Ile Tyr Leu Phe Met Leu Ile 
1                            5                               10                               15      


Val Ala Gly Pro Val Asp Leu Asn Glu Asn Ser Glu Gln Lys Glu Asn 
                     20                               25                                30          


Val Glu Lys Glu Gly Leu Cys Asn Ala Cys Thr Trp Arg Gln Asn Thr 
              35                                40                               45              


Lys Ser Ser Arg Ile Glu Ala Ile Lys Ile Gln Ile Leu Ser Lys Leu 
       50                             55                           60                  


Arg Leu Glu Thr Ala Pro Asn Ile Ser Lys Asp Val Ile Arg Gln Leu 
65                               70                              75                              80  


Leu Pro Lys Ala Pro Pro Leu Arg Glu Leu Ile Asp Gln Tyr Asp Val 
                            85                               90                              95      


Gln Arg Asp Asp Ser Ser Asp Gly Ser Leu Glu Asp Asp Asp Tyr His 
              100                                    105                              110         


Ala Thr Thr Glu Thr Ile Ile Thr Met Pro Thr Glu Ser Asp Phe Leu 
              115                         120                            125             


Met Gln Val Asp Gly Lys Pro Lys Cys Cys Phe Phe Lys Phe Ser Ser 
       130                             135                              140                 


Lys Ile Gln Tyr Asn Lys Val Val Lys Ala Gln Leu Trp Ile Tyr Leu 
145                           150                             155                           160 


Arg Pro Val Glu Thr Pro Thr Thr Val Phe Val Gln Ile Leu Arg Leu 
                            165                           170                           175     


Ile Lys Pro Met Lys Asp Gly Thr Arg Tyr Thr Gly Ile Arg Ser Leu 
                  180                              185                           190         


Lys Leu Asp Met Asn Pro Gly Thr Gly Ile Trp Gln Ser Ile Asp Val 
              195                              200                           205             


Lys Thr Val Leu Gln Asn Trp Leu Lys Gln Pro Glu Ser Asn Leu Gly 
       210                              215                            220                 


Ile Glu Ile Lys Ala Leu Asp Glu Asn Gly His Asp Leu Ala Val Thr 
225                         230                              235                             240 


Phe Pro Gly Pro Gly Glu Asp Gly Leu Asn Pro Phe Leu Glu Val Lys 
                           245                              250                             255     


Val Thr Asp Thr Pro Lys Arg Ser Arg Arg Asp Phe Gly Leu Asp Cys 
                     260                             265                             270         


Asp Glu His Ser Thr Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 
              275                            280                             285             


Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
       290                              295                         300                 


Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu Phe Val Phe Leu Gln Lys 
305                             310                             315                            320 


Tyr Pro His Thr His Leu Val His Gln Ala Asn Pro Arg Gly Ser Ala 
                           325                            330                             335     


Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 
                     340                            345                           350         


Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly Lys Ile Pro Ala Met Val 
               355                          360                          365             


Val Asp Arg Cys Gly Cys Ser 
       370                             375 


<210>  14
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys 
1                            5                                10                               15  


<210>  15
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Val Arg Ala Arg His Gln Pro Gly Gly Leu Cys Leu Leu Leu Leu 
1                          5                                10                                15      


Leu Leu Cys Gln Phe Met Glu Asp Arg Ser Ala Gln Ala Gly Asn Cys 
                      20                               25                               30          


Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu Tyr Lys Thr 
              35                                40                               45              


Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu Ser Thr Ser 
       50                              55                                60                  


Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys Trp Met Ile 
65                                70                               75                               80  


Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu Thr Cys Glu 
                            85                              90                               95      


Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn Lys Lys Asn 
                      100                            105                               110         


Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile Thr Trp Lys 
             115                             120                             125             


Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn Glu Cys Ala 
       130                            135                              140                 


Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu Val Gln Tyr 
145                             150                             155                             160 


Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys Pro Gly Ser 
                            165                              170                            175     


Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys Val Thr Cys 
                    180                             185                              190         


Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr Leu Cys Gly 
              195                           200                            205             


Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg Lys Ala Thr 
       210                             215                            220                 


Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly Lys Cys Ile 
225                              230                           235                            240 


Lys Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys 
                            245                           250                             255     


Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu 
                     260                             265                              270         


Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn 
              275                            280                             285             


Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser 
       290                           295                             300                 


Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn Ser Ile Ser 
305                             310                            315                           320 


Glu Asp Thr Glu Glu Glu Glu Glu Asp Glu Asp Gln Asp Tyr Ser Phe 
                            325                              330                             335     


Pro Ile Ser Ser Ile Leu Glu Trp 
                  340                 


<210>  16
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Asn Cys Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu 
1                           5                                 10                                15      


Tyr Lys Thr Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu 
                      20                               25                             30          


Ser Thr Ser Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys 
             35                              40                                 45              


Trp Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu 
       50                              55                               60                  


Thr Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn 
65                               70                                75                                80  


Lys Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile 
                             85                               90                              95      


Thr Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn 
                    100                             105                              110         


Glu Cys Ala Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu 
               115                             120                             125             


Val Gln Tyr Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys 
       130                             135                             140                 


Pro Gly Ser Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys 
145                           150                             155                             160 


Val Thr Cys Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr 
                            165                           170                            175     


Leu Cys Gly Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg 
                      180                             185                           190         


Lys Ala Thr Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly 
              195                              200                          205             


Lys Cys Ile Lys Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly 
       210                           215                           220                 


Lys Lys Cys Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu 
225                             230                              235                            240 


Cys Asp Glu Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala 
                             245                            250                             255     


Ser Asp Asn Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala 
                     260                            265                              270         


Cys Ser Ser Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn 
             275                             280                            285             


<210>  17
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEC2mƬ뼡Ƭ֮

<400>  17

Ser Ser Glu Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp 
1                           5                                 10                               15      


Asp His Tyr Val Ser Ala Thr Lys Val Met Ser Val Asp Lys Phe Leu 
                     20                              25                               30          


Ala His Asp Leu Ile Tyr Asn Ile Ser Asp Lys Lys Leu Lys Asn Tyr 
               35                            40                               45              


Asp Lys Val Lys Thr Glu Leu Leu Asn Glu Asp Leu Ala Lys Lys Tyr 
        50                               55                                60                  


Lys Asp Glu Val Val Asp Val Tyr Gly Ser Asn Tyr Tyr Val Asn Cys 
65                                70                               75                               80  


Tyr Phe Ser Ser Lys Asp Asn Val Gly Lys Val Thr Gly Gly Lys Thr 
                            85                               90                              95      


Cys Met Tyr Gly Gly Ile Thr Lys Tyr Glu Gly Asn His Phe Asp Asn 
                     100                            105                             110         


Gly Asn Leu Gln Asn Val Leu Ile Arg Val Tyr Glu Asn Lys Arg Asn 
               115                            120                             125             


Thr Ile Ser Phe Glu Val Gln Thr Asp Lys Lys Ser Val Thr Ala Gln 
      130                           135                             140                 


Glu Leu Asp Ile Lys Ala Arg Asn Phe Leu Ile Asn Lys Lys Asn Leu 
145                            150                            155                              160 


Tyr Glu Phe Asn Ser Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile 
                            165                           170                           175     


Glu Asn Asn Gly Asn Thr Phe Trp Tyr Asp Met Met Pro Ala Pro Gly 
                      180                             185                             190         


Asp Lys Phe Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys 
               195                            200                               205             


Thr Val Asp Ser Lys Ser Val Lys Ile Glu Val His Leu Thr Thr Lys 
       210                            215                           220                 


Asn Gly Leu Glu Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu 
225                              230                              235                            240 


Ser Arg Cys Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser 
                            245                               250                            255     


Arg Cys Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg 
                      260                              265                            270         


Cys Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys 
               275                              280                            285             


Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys Asp 
        290                              295                           300                 


Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys 
305                              310                             315             
