                         SEQUENCE LISTING

<110>  WUXI BIOLOGICS (SHANGHAI) CO., LTD.
       WUXI BIOLOGICS IRELAND LIMITED
 
<120>  NOVEL BISPECIFIC PD-1/EGFR ANTIBODY MOLECULES

<130>  053674-8024WO02

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Lama glama

<400>  1

Gly Arg Thr Phe Ser Ser Tyr Ala Met Gly 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Lama glama

<400>  2

Ala Asp Arg Trp Ser Gly Gly Asn Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  20
<212>  PRT
<213>  Lama glama

<400>  3

Thr Tyr Leu Ser Ser Asp Tyr Glu Trp Gly Val Pro Pro Lys Ala Tyr 
1               5                   10                  15      


Asp Tyr Asp Tyr 
            20  


<210>  4
<211>  129
<212>  PRT
<213>  Lama glama

<400>  4

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Asp Arg Trp Ser Gly Gly Asn Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Tyr Leu Ser Ser Asp Tyr Glu Trp Gly Val Pro Pro Lys 
            100                 105                 110         


Ala Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  5
<211>  387
<212>  DNA
<213>  Lama glama

<400>  5
gcggtacaac tggtggagtc tgggggaggt ctggtgcagg ctgggggttc tctgacgctc       60

tcctgtgcag cctctggacg caccttcagt agctatgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct gataggtgga gtggtggtaa cacacgctat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agccacatat      300

ttgagtagcg actatgagtg gggggtccct ccgaaggcct atgactatga ctactggggc      360

caggggaccc aggtcaccgt ctcctca                                          387


<210>  6
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Asp Arg Trp Ser Gly Gly Asn Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Tyr Leu Ser Ser Asp Tyr Glu Trp Gly Val Pro Pro Lys 
            100                 105                 110         


Ala Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  7
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
gccgtgcagc tggtggagag cggaggagga ctggtgcagc ctggcggaag cctgaccctg       60

tcctgcgctg ccagcggcag gaccttcagc agctacgcca tgggctggtt caggcaggct      120

cctggcaagg agagggagtt tgtggccgcc gacagatgga gcggcggcaa taccagatac      180

gccgacagcg tgaagggcag gttcaccatc agcagggata acgccaagaa taccctgtac      240

ctgcagatga actccctgag ggccgaggac accgccgtgt actactgcgc cgccacctac      300

ctgagcagcg attacgagtg gggcgtgccc cccaaggcct atgactacga ctactggggc      360

cagggcacac tggtgaccgt gagcagc                                          387


<210>  8
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Gly Phe Thr Phe Thr Thr Tyr Tyr Ile Ser 
1               5                   10  


<210>  9
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Arg Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Gly Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  10
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Tyr Ile Asn Met Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Leu Val Ser Thr Leu Gly Ser 
1               5           


<210>  12
<211>  6
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Ile Gly Tyr Phe Asp Tyr 
1               5       


<210>  13
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Gln Leu Thr His Trp Pro Tyr Thr 
1               5                   


<210>  14
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Tyr 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Tyr Leu 
        35                  40                  45              


Gly Tyr Ile Asn Met Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ile Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  15
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
caggtgcagc tggtccagtc tggagctgag gtgaagaaac ccggcagctc cgtgaaggtc       60

agttgcaaag catcaggctt cacttttacc acatactata tctcttgggt gaggcaggca      120

cctggacagg gcctggagta cctgggctat attaacatgg ggtccggcgg gaccaactac      180

aatgaaaagt tcaaagggcg ggtgactatc accgcagaca agtccacatc tactgcctat      240

atggagctgt ctagtctgag atccgaagac acagccgtct actattgtgc tattatcggc      300

tactttgatt attgggggca gggaacgatg gtgacagtct caagc                      345


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Gly Thr Tyr Leu Tyr Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Thr Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Leu 
                85                  90                  95      


Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
gacgtggtca tgactcagtc tcccctgtcc ctgcctgtga ccctgggaca gccagcctct       60

atcagttgcc gaagctccca gtcactgctg gacagcgatg ggggtacata cctgtattgg      120

tttcagcaga gaccaggaca gagcccccgg cggctgatct acctggtgtc caccctggga      180

tctggagtcc ctgacaggtt ctcaggaagc ggctccggga ccgacttcac cctgaagatt      240

agccgcgtgg aggccgaaga tgtgggggtc tactattgta tgcagctgac tcactggcca      300

tatacctttg gacagggcac aaagctggag atcaag                                336


<210>  18
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Gly Thr Tyr Leu Tyr Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Thr Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Leu 
                85                  90                  95      


Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  19
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Asp Ser Ile Ser Ser Thr Thr Tyr Tyr Trp Val 
1               5                   10          


<210>  20
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  20

Thr Gly Thr Ser Ser Asp Val Gly Phe Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  21
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  22
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Val Ser Asn Arg Pro Ser 
1               5           


<210>  23
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  23

His Leu Gly Tyr Asn Gly Arg Tyr Leu Pro Phe Asp Tyr 
1               5                   10              


<210>  24
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  24

Ser Ser Tyr Thr Asn Ile Ser Thr Trp Val 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  25

Ser Ser Tyr Thr Ser Ile Ser Thr Trp Val 
1               5                   10  


<210>  26
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Ala Asp Ser Ile Ser Ser Thr 
            20                  25                  30          


Thr Tyr Tyr Trp Val Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Val Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Asn Ser Val Ala Ala Thr Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Leu Gly Tyr Asn Gly Arg Tyr Leu Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  27
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  27
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgaccctc       60

acctgcactg tctctgctga ctccatcagc agtactactt actactgggt ctggatccgc      120

cagcccccag ggaagggact ggagtggatt gggagtatct cttatagtgg gagcacctac      180

tacaatccgt ccctcaagag tcgagtcacc gtatccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgaactctgt ggccgccaca gacacggctc tatattactg tgcgagacat      300

ctagggtata atgggaggta cctccccttt gactactggg gccagggaac cctggtcacc      360

gtctcctcc                                                              369


<210>  28
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Phe Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Glu Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Asn Ile 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  29
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  29
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ttttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccga actcatgatt tatgatgtca gtaatcggcc ctcaggggtt      180

tctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caaacatcag cacttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  30
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Phe Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Glu Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ile 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  31
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  31
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ttttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccga actcatgatt tatgatgtca gtaatcggcc ctcaggggtt      180

tctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcatcag cacttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  32
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Asp Arg Trp Ser Gly Gly Asn Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Tyr Leu Ser Ser Asp Tyr Glu Trp Gly Val Pro Pro Lys 
            100                 105                 110         


Ala Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser 
    130                 135                 140                 


Leu Pro Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Gln Ser Leu Leu Asp Ser Asp Gly Gly Thr Tyr Leu Tyr Trp Tyr Gln 
                165                 170                 175     


Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr Leu Val Ser Thr 
            180                 185                 190         


Leu Gly Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Met Gln Leu Thr His Trp Pro Tyr Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
            260                 265                 270         


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
        275                 280                 285             


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
    290                 295                 300                 


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
305                 310                 315                 320 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
                325                 330                 335     


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            340                 345                 350         


Cys 
    


<210>  33
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Tyr 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Tyr Leu 
        35                  40                  45              


Gly Tyr Ile Asn Met Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ile Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  34
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  35
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Asp Arg Trp Ser Gly Gly Asn Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Tyr Leu Ser Ser Asp Tyr Glu Trp Gly Val Pro Pro Lys 
            100                 105                 110         


Ala Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val 
    130                 135                 140                 


Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser 
145                 150                 155                 160 


Ser Asp Val Gly Phe Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro 
                165                 170                 175     


Gly Lys Ala Pro Glu Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser 
            180                 185                 190         


Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
        195                 200                 205             


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ser Ser Tyr Thr Ser Ile Ser Thr Trp Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
                245                 250                 255     


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
            260                 265                 270         


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
        275                 280                 285             


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
    290                 295                 300                 


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
305                 310                 315                 320 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
                325                 330                 335     


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345                 350     


<210>  36
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Ala Asp Ser Ile Ser Ser Thr 
            20                  25                  30          


Thr Tyr Tyr Trp Val Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Val Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Asn Ser Val Ala Ala Thr Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Leu Gly Tyr Asn Gly Arg Tyr Leu Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  37
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  37

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Gly Gly Gly Gly Ser 
1               5   


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  41
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


