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<110>  WUXI BIOLOGICS (SHANGHAI) CO., LTD.
       WUXI BIOLOGICS IRELAND LIMITED
 
<120>  NOVEL BISPECIFIC PD-1/CD47 ANTIBODY MOLECULES

<130>  053674-8029WO02

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  1

Gly Phe Thr Phe Ser Thr Tyr Gly Met Ala 
1               5                   10  


<210>  2
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Ser Gly Ile Glu Leu Ser Asn Lys Tyr Ala His 
1               5                   10      


<210>  3
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Ser Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Lys Asp Ser Glu Arg Pro Ser 
1               5           


<210>  5
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Lys Gly Gly Arg Thr Tyr Arg Leu Ala Tyr 
1               5                   10  


<210>  6
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Leu Ser Thr Asn Ser Asp Asp Asp Leu Pro Val 
1               5                   10      


<210>  7
<211>  119
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Glu Val Glu Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Thr Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Lys Gly Gly Arg Thr Tyr Arg Leu Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  8
<211>  357
<212>  DNA
<213>  Rattus norvegicus

<400>  8
gaggtagaac tggtggagtc tgggggcgac ttagtgcagc ctggaaggtc catgaaactc       60

tcctgtgcag cctcaggatt cactttcagt acctatggca tggcctgggt ccgccagact      120

ccaacgaagg gtctggagtg ggtcgcatcc attagtacta gtggtggcag cacttactat      180

cgagactccg tgcagggccg attcactatt tccagagata atgcaaagag caccctatac      240

ctacaaatgg acagtctgac gtctgaggac acggccactt attactgtac aactaagggg      300

gggagaacct ataggcttgc ttactggggc caaggcactc tggtcactgt ctcttca         357


<210>  9
<211>  108
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Ser Tyr Glu Leu Ile Gln Pro Pro Ser Ala Ser Val Thr Leu Glu Asn 
1               5                   10                  15      


Thr Val Ser Leu Thr Cys Ser Gly Ile Glu Leu Ser Asn Lys Tyr Ala 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Asp Lys Thr Ile Leu Glu Val Met Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Arg Ser Gly Thr Thr Ala Ile Leu Thr Ile Arg Asp Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Thr Asn Ser Asp Asp Asp Leu 
                85                  90                  95      


Pro Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 
            100                 105             


<210>  10
<211>  324
<212>  DNA
<213>  Rattus norvegicus

<400>  10
agctatgagc tgatccaacc accatcagca tcagtcactc tggaaaatac tgtctcactc       60

acttgttctg gaattgaatt atcaaacaaa tatgctcatt ggtttcaaca aaagccagac      120

aagaccattt tggaagtgat gtacaaagat agtgagcggc cctcaggcat ctctgaccga      180

ttctctgggt ccaggtcagg gacaacagcc attctgacaa tccgtgatgc ccaggctgag      240

gatgaggctg attattactg tttgtcaaca aatagtgatg atgatctccc tgttttcggt      300

ggtggaaccg agctcactgt ccta                                             324


<210>  11
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Lys Gly Gly Arg Thr Tyr Arg Leu Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  12
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
gaggtgcagc tggtggagag cggaggagga ctggtgcagc ccggaagaag cctgagactg       60

agctgcgccg ccagcggctt taccttcagc acctacggca tggcctgggt gagacaggcc      120

cccggcaaag gactggagtg ggtgagcagc atcagcacca gcggcggcag cacctactac      180

agggacagcg tgcagggaag gttcaccatc agcagggaca acgccaagag cagcctgtat      240

ctgcagatga acagcctgag ggccgaggac accgccacct actactgcac caccaagggc      300

ggcaggacct acaggctggc ctattggggc cagggcaccc tggtgacagt gagctcc         357


<210>  13
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Ser Tyr Glu Leu Met Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Ile Glu Leu Ser Asn Lys Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Glu Val Met Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Arg Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Thr Asn Ser Asp Asp Asp Leu 
                85                  90                  95      


Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  14
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
agctacgagc tgatgcagcc tcctagcgtg agcgtgagcc ccggacagac agccaggatc       60

acctgcagcg gcatcgagct gagcaacaag tacgcccact ggtaccagca gaagcctggc      120

caggcccctg tggaggtgat gtacaaggac agcgagagac ccagcggcat ccccgagagg      180

tttagcggca gcaggagcgg caccaccgtg accctgacca tcagcggagt gcaggccgag      240

gatgaggccg actactactg cctgagcacc aacagcgatg acgacctgcc tgtgttcggc      300

ggcggcacca agttaaccgt ccta                                             324


<210>  15
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Gly Phe Thr Phe Thr Thr Tyr Tyr Ile Ser 
1               5                   10  


<210>  16
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Arg Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Gly Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  17
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Tyr Ile Asn Met Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Leu Val Ser Thr Leu Gly Ser 
1               5           


<210>  19
<211>  6
<212>  PRT
<213>  Rattus norvegicus

<400>  19

Ile Gly Tyr Phe Asp Tyr 
1               5       


<210>  20
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  20

Met Gln Leu Thr His Trp Pro Tyr Thr 
1               5                   


<210>  21
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Tyr 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Tyr Leu 
        35                  40                  45              


Gly Tyr Ile Asn Met Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ile Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  22
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
caggtgcagc tggtccagtc tggagctgag gtgaagaaac ccggcagctc cgtgaaggtc       60

agttgcaaag catcaggctt cacttttacc acatactata tctcttgggt gaggcaggca      120

cctggacagg gcctggagta cctgggctat attaacatgg ggtccggcgg gaccaactac      180

aatgaaaagt tcaaagggcg ggtgactatc accgcagaca agtccacatc tactgcctat      240

atggagctgt ctagtctgag atccgaagac acagccgtct actattgtgc tattatcggc      300

tactttgatt attgggggca gggaacgatg gtgacagtct caagc                      345


<210>  23
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Gly Thr Tyr Leu Tyr Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Thr Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Leu 
                85                  90                  95      


Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  24
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
gacgtggtca tgactcagtc tcccctgtcc ctgcctgtga ccctgggaca gccagcctct       60

atcagttgcc gaagctccca gtcactgctg gacagcgatg ggggtacata cctgtattgg      120

tttcagcaga gaccaggaca gagcccccgg cggctgatct acctggtgtc caccctggga      180

tctggagtcc ctgacaggtt ctcaggaagc ggctccggga ccgacttcac cctgaagatt      240

agccgcgtgg aggccgaaga tgtgggggtc tactattgta tgcagctgac tcactggcca      300

tatacctttg gacagggcac aaagctggag atcaag                                336


<210>  25
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Gly Thr Tyr Leu Tyr Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Thr Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Leu 
                85                  90                  95      


Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
    130                 135                 140                 


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Thr Thr Tyr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly 
                165                 170                 175     


Leu Glu Tyr Leu Gly Tyr Ile Asn Met Gly Ser Gly Gly Thr Asn Tyr 
            180                 185                 190         


Asn Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
        195                 200                 205             


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Ile Ile Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Met Val Thr Val Ser Ser 
                245         


<210>  26
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Ile Glu Leu Ser Asn Lys Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Glu Val Met Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Arg Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Thr Asn Ser Asp Asp Asp Leu 
                85                  90                  95      


Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  27
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Ile Glu Leu Ser Asn Lys Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Glu Val Met Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Arg Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Thr Asn Ser Asp Asp Asp Leu 
                85                  90                  95      


Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
145                 150                 155                 160 


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                165                 170                 175     


Ser Ser Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val 
            180                 185                 190         


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Thr Thr Lys Gly Gly Arg Thr Tyr Arg Leu Ala Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  28
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Gly Thr Tyr Leu Tyr Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Thr Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Leu 
                85                  90                  95      


Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  29
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Gly Thr Tyr Leu Tyr Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Thr Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Leu 
                85                  90                  95      


Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
    130                 135                 140                 


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Thr Thr Tyr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly 
                165                 170                 175     


Leu Glu Tyr Leu Gly Tyr Ile Asn Met Gly Ser Gly Gly Thr Asn Tyr 
            180                 185                 190         


Asn Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
        195                 200                 205             


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Ile Ile Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
                245                 250                 255     


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu 
            260                 265                 270         


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Gly Met Ala Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
    290                 295                 300                 


Thr Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val Gln Gly Arg Phe 
305                 310                 315                 320 


Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asn 
                325                 330                 335     


Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Thr Thr Lys Gly 
            340                 345                 350         


Gly Arg Thr Tyr Arg Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        355                 360                 365             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    370                 375                 380                 


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
385                 390                 395                 400 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                405                 410                 415     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            420                 425                 430         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        435                 440                 445             


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
    450                 455                 460                 


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
465                 470                 475                 480 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                485                 490                 495     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            500                 505                 510         


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
        515                 520                 525             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    530                 535                 540                 


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
545                 550                 555                 560 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                565                 570                 575     


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            580                 585                 590         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
        595                 600                 605             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    610                 615                 620                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
625                 630                 635                 640 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                645                 650                 655     


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
            660                 665                 670         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        675                 680                 685             


Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    690                 695         


<210>  30
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Ile Glu Leu Ser Asn Lys Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Glu Val Met Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Arg Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Thr Asn Ser Asp Asp Asp Leu 
                85                  90                  95      


Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  31
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Tyr 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Tyr Leu 
        35                  40                  45              


Gly Tyr Ile Asn Met Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ile Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly 
        435                 440                 445             


Gly Gly Ser Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser 
    450                 455                 460                 


Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Ile Glu Leu Ser Asn 
465                 470                 475                 480 


Lys Tyr Ala His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Glu 
                485                 490                 495     


Val Met Tyr Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe 
            500                 505                 510         


Ser Gly Ser Arg Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val 
        515                 520                 525             


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Thr Asn Ser Asp 
    530                 535                 540                 


Asp Asp Leu Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            580                 585                 590         


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        595                 600                 605             


Ser Thr Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    610                 615                 620                 


Glu Trp Val Ser Ser Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Arg 
625                 630                 635                 640 


Asp Ser Val Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser 
                645                 650                 655     


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
            660                 665                 670         


Tyr Tyr Cys Thr Thr Lys Gly Gly Arg Thr Tyr Arg Leu Ala Tyr Trp 
        675                 680                 685             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    690                 695             


<210>  32
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Gly Thr Tyr Leu Tyr Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Thr Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Leu 
                85                  90                  95      


Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  33
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  34
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  34

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  35
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Gly Gly Gly Gly Ser 
1               5   


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  38
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Thr Gly Gly Gly Gly 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Ser Gly Gly Gly Gly 
1               5   


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


