﻿               SEQUENCE LISTING

<110> Fundació Centre de Regulació Genòmica

<120> ANTISENSE OLIGONUCLEOTIDES AND USES THEREOF

<130> P42288WO

<140>
<141>

<150> EP18162571.6
<151> 2018-03-19

<160> 357

<170> BiSSAP 1.3

<210> 1
<211> 147
<212> DNA
<213> Mus Musculus

<220> 
<223> NM_001136075.2  - Numb mRNA transcript variant 1 – 1115..1261


<400> 1
ctaatggcac tgactcagcc tcccatgtgc ttactgctaa gccagccaat actgctctag     60

cacacgtagc aatgcctgtc cgtgaaacca acccctgggc ccatgtccct gatgctgcta    120

acaaggaaat tgcagccata catccgg                                        147


<210> 2
<211> 144
<212> DNA
<213> Homo sapiens

<220> 
<223> NM_001005743 – Numb mRNA transcript variant 1-1417..1560


<400> 2
ctaatggcac tgactcagcc ttccatgtgc ttgctaagcc agcccatact gctctagcac     60

ccgtagcaat gcctgtgcgt gaaaccaacc cttgggccca tgcccctgat gctgctaaca    120

aggaaattgc agccacatgt tcgg                                           144


<210> 3
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Region 2 of Homo sapiens Numb exon 9 (targeted by AON2 - SEQ ID NO: 13)

<400> 3
ccuuccaugu gcuugcuaag c                                               21


<210> 4
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Region 3 of Homo sapiens Numb exon 9 (targeted by AON3 - SEQ ID NO: 14)

<400> 4
cagcccauac ugcucuagca c                                               21


<210> 5
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Region 4 of Homo sapiens Numb exon 9 (targeted by AON4 - SEQ ID NO: 15) 

<400> 5
ccguagcaau gccugugcgu g                                               21


<210> 6
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Region 5 of Homo sapiens Numb exon 9 (targeted by AON5 - SEQ ID NO: 16)

<400> 6
aaaccaaccc uugggcccau g                                               21


<210> 7
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Region 6 of Homo sapiens Numb exon 9 (targeted by AON6 - SEQ ID NO: 17)

<400> 7
ccccugaugc ugcuaacaag g                                               21


<210> 8
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Region 7 of Homo sapiens Numb exon 9 (targeted by AON7 - SEQ ID NO: 18)

<400> 8
aaauugcagc cacauguucg g                                               21

<210> 9
<211> 39
<212> RNA
<213> Homo sapiens

<220> 
<223> Region 1+2 of Homo sapiens Numb exon 9 (targeted by AON1 - SEQ ID NO: 12 ; AON2 - SEQ ID NO: 13; and AON1-2 - SEQ ID NO: 19) 

<400> 9
cuaauggcac ugacucagcc uuccaugugc uugcuaagc                            39

<210> 10
<211> 42
<212> RNA
<213> Homo sapiens

<220> 
<223> Region 4+5 of Homo sapiens Numb exon 9 (targeted by AON4 - SEQ ID NO:  15; AON5 - SEQ ID NO:16; and AON4-5 - SEQ ID NO: 22) 

<400> 10
ccguagcaau gccugugcgu gaaaccaacc cuugggccca ug                        42

<210> 11
<211> 42
<212> RNA
<213> Homo sapiens

<220> 
<223> Region 6+7 of Homo sapiens Numb exon 9 (targeted by AON6 - SEQ ID NO: 17; AON7 - SEQ ID NO: 18 and AON6-7 - SEQ ID NO: 24) 

<400> 11
ccccugaugc ugcuaacaag gaaauugcag ccacauguuc gg                        42

<210> 12
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 1 of Homo sapiens Numb exon 9 (AON1)

<400> 12
aggcugaguc agugccauua g                                               21

<210> 13
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 2 of Homo sapiens Numb exon 9 (AON2) 

<400> 13
gcuuagcaag cacauggaag g                                               21

<210> 14
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 3 of Homo sapiens Numb exon 9 (AON3) 

<400> 14
gugcuagagc aguaugggcu g                                               21

<210> 15
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 4 of Homo sapiens Numb exon 9 (AON4) 

<400> 15
cacgcacagg cauugcuacg g                                               21

<210> 16
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 5 of Homo sapiens Numb exon 9 (AON5) 

<400> 16
caugggccca aggguugguu u                                               21

<210> 17
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 6 of Homo sapiens Numb exon 9 (AON6) 

<400> 17
ccuuguuagc agcaucaggg g                                               21

<210> 18
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 7 of Homo sapiens Numb exon 9 (AON7) 

<400> 18
ccgaacaugu ggcugcaauu u                                               21

<210> 19
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 1-2 of Homo sapiens Numb exon 9 (AON1-2) 

<400> 19
cacauggaag gcugagucag u                                               21

<210> 20
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 2-3 of Homo sapiens Numb exon 9 (AON2-3) 

<400> 20
aguaugggcu ggcuuagcaa g                                               21

<210> 21
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 3-4 of Homo sapiens Numb exon 9 (AON3-4) 

<400> 21
cauugcuacg ggugcuagag c                                               21

<210> 22
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 4-5 of Homo sapiens Numb exon 9 (AON4-5) 

<400> 22
aggguugguu ucacgcacag g                                               21

<210> 23
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 5-6 of Homo sapiens Numb exon 9 (AON5-6)

<400> 23
agcaucaggg gcaugggccc a                                               21

<210> 24
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 6-7 of Homo sapiens Numb exon 9 (AON6-7)

<400> 24
ggcugcaauu uccuuguuag c                                               21

<210> 25
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting the 5' splice site of Numb exon 9

<400> 25
aucuguggcc accuuacccg a                                               21

<210> 26
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting the 3' splice site of Homo sapiens Numb exon 9

<400> 26
uuagcuacaa cgggagcaga c                                               21

<210> 27
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Homo sapiens Numb exon 9 sequence targeted by antisense oligonucleotide of SEQ. ID NO: 25

<400> 27
ucggguaagg uggccacagau                                                21

<210> 28
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Homo sapiens Numb exon 9 sequence targeted by antisense oligonucleotide of SEQ. ID NO: 26

<400> 28
gtctgctccc gttgtagcta a                                               21

<210> 29
<211> 23
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting the branching point of  Homo sapiens Numb exon 9

<400> 29
caacaucaau ggaguuaauu cau                                             23

<210> 30
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Region of Homo sapiens Numb exon 9 targeted by SEQ.ID NO: 19 (AON1-2)

<400> 30
acugacucag ccuuccaugu g                                               21

<210> 31
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Region of Homo sapiens Numb exon 9 targeted by SEQ.ID NO: 22 (AON4-5)

<400> 31
ccugugcgug aaaccaaccc u                                               21

<210> 32
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Region of Homo sapiens Numb exon 9 targeted by SEQ.ID NO: 24 (AON6-7)

<400> 32
gcuaacaagg aaauugcagc c                                               21

<210> 33
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Region of Homo sapiens Numb exon 9 targeted by SEQ.ID NO: 20 (AON2-3)

<400> 33
cuugcuaagc cagcccauac u                                               21

<210> 34
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Region of Homo sapiens Numb exon 9 targeted by SEQ.ID NO: 21 (AON3-4)

<400> 34
gcucuagcac ccguagcaau g                                               21

<210> 35
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> Region of Homo sapiens Numb exon 9 targeted by SEQ.ID NO: 23 (AON5-6)

<400> 35
ugggcccaug ccccugaugc u                                               21

<210> 36
<211> 7
<212> RNA
<213> Artificial sequence

<220> 
<223> Antisense oligonucleotide targeting region 1 of  Homo sapiens Numb exon 9

<400> 36
aggcuga                                                                7

<210> 37
<211> 7

<212> RNA
<213> Artificial sequence

<220> 
<223> 37: Antisense oligonucleotide targeting region 1 of  Homo sapiens Numb exon 9

<400> 37
gucagug                                                                7

<210> 38
<211> 7

<212> RNA
<213> Artificial sequence

<220> 
<223> 38: Antisense oligonucleotide targeting region 1 of  Homo sapiens Numb exon 9

<400> 38
ccauuag                                                                7

<210> 39
<211> 7


<212> RNA
<213> Artificial sequence

<220> 
<223> 39: Antisense oligonucleotide targeting region 1-2 of  Homo sapiens Numb exon 9

<400> 39
cugaguc                                                                7

<210> 40
<211> 7


<212> RNA
<213> Artificial sequence

<220> 
<223> 40: Antisense oligonucleotide targeting region 2-3 of  Homo sapiens Numb exon 9
<400> 40
agugcca                                                                7

<210> 41
<211> 14

<212> RNA
<213> Artificial sequence

<220> 
<223> 41: Antisense oligonucleotide targeting region 1 of  Homo sapiens Numb exon 9
<400> 41
aggcugaguc agug                                                       14

<210> 42
<211> 14


<212> RNA
<213> Artificial sequence

<220> 
<223> 42: Antisense oligonucleotide targeting region 1 of  Homo sapiens Numb exon 9
<400> 42
gucagugcca uuag                                                       14

<210> 43
<211> 21


<212> RNA
<213> Artificial sequence

<220> 
<223> 43: Antisense oligonucleotide targeting region 1 of  Homo sapiens Numb exon 9

<220>
<221> cm
<222> 4

<220>
<221> cm
<222> 10

<220>
<221> cm
<222> 15

<220>
<221> cm
<222> 16

<400> 43
aggcugaguc agugccauua g                                               21

<210> 44
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<223> 44: Region 1 of Homo sapiens Numb exon 9 (targeted by AON1 - SEQ ID NO:12)

<400> 44
cuaauggcac ugacucagcc u                                               21

<210> 45
<211> 7


<212> RNA
<213> Homo sapiens

<220> 
<223> 45: Target regions in region 1+2 of  Homo sapiens Numb exon 9
<400> 45
cuaaugg                                                                7

<210> 46
<211> 7


<212> RNA
<213> Homo sapiens

<220> 46: Target regions in region 1+2 of  Homo sapiens Numb exon 9

<400> 46
uaauggc                                                                7

<210> 47
<211> 7


<212> RNA
<213> Homo sapiens

<220> 47: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 47
aauggca                                                                7

<210> 48
<211> 7

<212> RNA
<213> Homo sapiens

<220> 48: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 48
auggcac                                                                7

<210> 49
<211> 7


<212> RNA
<213> Homo sapiens

<220> 49: target regions in region 1+2 of  homo sapiens numb exon 9

<400> 49
uggcacu                                                                7

<210> 50
<211> 7


<212> RNA
<213> Homo sapiens

<220> 50: target regions in region 1+2 of  homo sapiens numb exon 9

<400> 50
ggcacug                                                                7

<210> 51
<211> 7


<212> RNA
<213> Homo sapiens

<220> 51: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 51
gcacuga                                                                7

<210> 52
<211> 7

<212> RNA
<213> Homo sapiens

<220> 52: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 52
cacugac                                                                7


<210> 53
<211> 7

<212> RNA
<213> Homo sapiens

<220> 53: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 53
acugacu                                                                7

<210> 54
<211> 7


<212> RNA
<213> Homo sapiens

<220>  54: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 54
cugacuc                                                                7

<210> 55
<211> 7


<212> RNA
<213> Homo sapiens

<220> 55: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 55
ugacuca                                                                7

<210> 56
<211> 7


<212> RNA
<213> Homo sapiens

<220> 56: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 56
gacucag                                                                7

<210> 57
<211> 7

<212> RNA
<213> Homo sapiens

<220> 57: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 57
acucagc                                                                7

<210> 58
<211> 7


<212> RNA
<213> Homo sapiens

<220> 58: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 58
cucagcc                                                                7

<210> 59
<211> 7


<212> RNA
<213> Homo sapiens

<220> 59: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 59
ucagccu                                                                7

<210> 60
<211> 7


<212> RNA
<213> Homo sapiens

<220> 60: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 60
cagccuu                                                                7

<210> 61
<211> 7

<212> RNA
<213> Homo sapiens

<220>  61: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 61
agccuuc                                                                7

<210> 62
<211> 7


<212> RNA
<213> Homo sapiens

<220> 62: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 62
gccuucc                                                                7

<210> 63
<211> 7


<212> RNA
<213> Homo sapiens

<220> 63: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 63
ccuucca                                                                7

<210> 64
<211> 7

<212> RNA
<213> Homo sapiens

<220> 64: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 64
cuuccau                                                                7

<210> 65
<211> 7

<212> RNA
<213> Homo sapiens

<220> 65: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 65
uuccaug                                                                7

<210> 66
<211> 7

<212> RNA
<213> Homo sapiens

<220> 66: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 66
uccaugu                                                                7

<210> 67
<211> 7

<212> RNA
<213> Homo sapiens

<220> 67: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 67
ccaugug                                                                7

210> 68
<211> 7

<212> RNA
<213> Homo sapiens

<220> 68: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 68
caugugc                                                                7

<210> 69
<211> 7


<212> RNA
<213> Homo sapiens

<220> 69: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 69
augugcu                                                                7

<210> 70
<211> 7

<212> RNA
<213> Homo sapiens

<220> 70: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 70
ugugcuu                                                                7

<210> 71
<211> 7


<212> RNA
<213> Homo sapiens

<220> 71: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 71
gugcuug                                                                7

<210> 72
<211> 7

<212> RNA
<213> Homo sapiens

<220> 72: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 72
ugcuugc                                                                7

<210> 73
<211> 7

<212> RNA
<213> Homo sapiens

<220> 73: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 73
gcuugcu                                                                7

<210> 74
<211> 7

<212> RNA
<213> Homo sapiens

<220> 74: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 74
cuugcua                                                                7

<210> 75
<211> 7

<212> RNA
<213> Homo sapiens

<220> 75: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 75
uugcuaa                                                                7

<210> 76
<211> 7

<212> RNA
<213> Homo sapiens

<220> 76: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 76
ugcuaag                                                                7

<210> 77
<211> 7

<212> RNA
<213> Homo sapiens

<220> 77: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 77
gcuaagc                                                                7


<210> 78
<211> 13

<212> RNA
<213> Homo sapiens

<220> 78: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 78
cuaauggcac uga                                                        13

<210> 79
<211> 13

<212> RNA
<213> Homo sapiens

<220> 79: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 77
uaauggcacu gac                                                        13

<210> 80
<211> 13

<212> RNA
<213> Homo sapiens

<220> 80: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 80
aauggcacug acu                                                        13

<210> 81
<211> 13

<212> RNA
<213> Homo sapiens

<220> 81: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 81
auggcacuga cuc                                                        13

<210> 82
<211> 13

<212> RNA
<213> Homo sapiens

<220> 82: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 82
uggcacugac uca                                                        13

<210> 83
<211> 13

<212> RNA
<213> Homo sapiens

<220> 83: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 83
ggcacugacu cag                                                        13

<210> 84
<211> 13

<212> RNA
<213> Homo sapiens

<220> 84: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 84
gcacugacuc agc                                                        13

<210> 85
<211> 13

<212> RNA
<213> Homo sapiens

<220> 85: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 85
cacugacuca gcc                                                        13

<210> 86
<211> 13

<212> RNA
<213> Homo sapiens

<220> 86: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 86
acugacucag ccu                                                        13

<210> 87
<211> 13

<212> RNA
<213> Homo sapiens

<220> 87: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 87
cugacucagc cuu                                                        13

<210> 88
<211> 13

<212> RNA
<213> Homo sapiens

<220> 88: target regions in region 1+2 of  homo sapiens numb exon 9
<400> 88
ugacucagcc uuc                                                        13

<210> 89
<211> 13

<212> RNA
<213> Homo sapiens

<220> 89: target regions in region 1+2 of homo sapiens numb exon 9
<400> 89
gacucagccu ucc                                                        13

<210> 90
<211> 13

<212> RNA
<213> Homo sapiens

<220> 90: target regions in region 1+2 of homo sapiens numb exon 9
<400> 90
acucagccuu cca                                                        13

<210> 91
<211> 13

<212> RNA
<213> Homo sapiens

<220> 91: target regions in region 1+2 of homo sapiens numb exon 9
<400> 91
cucagccuuc cau                                                        13

<210> 92
<211> 13

<212> RNA
<213> Homo sapiens

<220> 92: target regions in region 1+2 of homo sapiens numb exon 9
<400> 92
ucagccuucc aug                                                        13

<210> 93
<211> 13

<212> RNA
<213> Homo sapiens

<220> 93: target regions in region 1+2 of homo sapiens numb exon 9
<400> 93
cagccuucca ugu                                                        13

<210> 94
<211> 13

<212> RNA
<213> Homo sapiens

<220> 94: target regions in region 1+2 of homo sapiens numb exon 9
<400> 94
agccuuccau gug                                                        13

<210> 95
<211> 13

<212> RNA
<213> Homo sapiens

<220> 95: target regions in region 1+2 of homo sapiens numb exon 9
<400> 95
gccuuccaug ugc                                                        13

<210> 96
<211> 13

<212> RNA
<213> Homo sapiens

<220> 96: target regions in region 1+2 of homo sapiens numb exon 9
<400> 96
ccuuccaugu gcu                                                        13

<210> 97
<211> 13

<212> RNA
<213> Homo sapiens

<220> 97: target regions in region 1+2 of homo sapiens numb exon 9
<400> 97
cuuccaugug cuu                                                        13

<210> 98
<211> 13

<212> RNA
<213> Homo sapiens

<220> 98: target regions in region 1+2 of homo sapiens numb exon 9
<400> 98
uuccaugugc uug                                                        13 

<210> 99
<211> 13

<212> RNA
<213> Homo sapiens

<220> 99: target regions in region 1+2 of homo sapiens numb exon 9
<400> 99
uccaugugcu ugc                                                        13

<210> 100
<211> 13

<212> RNA
<213> Homo sapiens

<220> 100: target regions in region 1+2 of homo sapiens numb exon 9
<400> 100
ccaugugcuu gcu                                                        13

<210> 101
<211> 13

<212> RNA
<213> Homo sapiens

<220> 101: target regions in region 1+2 of homo sapiens numb exon 9
<400> 101
caugugcuug cua                                                        13

<210> 102
<211> 13

<212> RNA
<213> Homo sapiens

<220> 102: target regions in region 1+2 of homo sapiens numb exon 9
<400> 102
augugcuugc uaa                                                        13

<210> 403
<211> 13

<212> RNA
<213> Homo sapiens

<220> 103: target regions in region 1+2 of homo sapiens numb exon 9
<400> 103
ugugcuugcu aag                                                        13

<210> 104
<211> 13

<212> RNA
<213> Homo sapiens

<220> 104: target regions in region 1+2 of homo sapiens numb exon 9
<400> 104
gugcuugcua agc                                                        13

<210> 105
<211> 21

<212> RNA
<213> Homo sapiens

<220> 105: target regions in region 1+2 of homo sapiens numb exon 9
<400> 105
cuaauggcac ugacucagcc u                                               21

<210> 106
<211> 21

<212> RNA
<213> Homo sapiens

<220> 106: target regions in region 1+2 of homo sapiens numb exon 9
<400> 106
uaauggcacu gacucagccu u                                               21

<210> 107
<211> 21

<212> RNA
<213> Homo sapiens

<220> 107: target regions in region 1+2 of homo sapiens numb exon 9
<400> 107
aauggcacug acucagccuu c                                               21

<210> 108
<211> 21

<212> RNA
<213> Homo sapiens

<220> 108: target regions in region 1+2 of homo sapiens numb exon 9
<400> 108
auggcacuga cucagccuuc c                                               21

<210> 109
<211> 21

<212> RNA
<213> Homo sapiens

<220> 109: target regions in region 1+2 of homo sapiens numb exon 9
<400> 109
uggcacugac ucagccuucc a                                               21

<210> 110
<211> 21

<212> RNA
<213> Homo sapiens

<220> 110: target regions in region 1+2 of homo sapiens numb exon 9
<400> 110
ggcacugacu cagccuucca u                                               21

<210> 111
<211> 21

<212> RNA
<213> Homo sapiens

<220> 111: target regions in region 1+2 of homo sapiens numb exon 9
<400> 111
gcacugacuc agccuuccau g                                               21

<210> 112
<211> 21

<212> RNA
<213> Homo sapiens

<220> 112: target regions in region 1+2 of homo sapiens numb exon 9
<400> 112
cacugacuca gccuuccaug u                                               21

<210> 113
<211> 21

<212> RNA
<213> Homo sapiens

<220> 113: target regions in region 1+2 of homo sapiens numb exon 9
<400> 113
acugacucag ccuuccaugu g                                               21

<210> 114
<211> 21

<212> RNA
<213> Homo sapiens

<220> 114: target regions in region 1+2 of homo sapiens numb exon 9
<400> 114
cugacucagc cuuccaugug c                                               21

<210> 115
<211> 21

<212> RNA
<213> Homo sapiens

<220> 115: target regions in region 1+2 of homo sapiens numb exon 9
<400> 115
ugacucagcc uuccaugugc u                                               21

<210> 116
<211> 21

<212> RNA
<213> Homo sapiens

<220> 116: target regions in region 1+2 of homo sapiens numb exon 9
<400> 116
gacucagccu uccaugugcu u                                               21

<210> 117
<211> 21

<212> RNA
<213> Homo sapiens

<220> 117: target regions in region 1+2 of homo sapiens numb exon 9
<400> 117
acucagccuu ccaugugcuu g                                               21

<210> 118
<211> 21

<212> RNA
<213> Homo sapiens

<220> 118: target regions in region 1+2 of homo sapiens numb exon 9
<400> 118
cucagccuuc caugugcuug c                                               21

<210> 119
<211> 21

<212> RNA
<213> Homo sapiens

<220> 119: target regions in region 1+2 of homo sapiens numb exon 9
<400> 119
ucagccuucc augugcuugc u                                               21

<210> 120
<211> 21

<212> RNA
<213> Homo sapiens

<220> 120: target regions in region 1+2 of homo sapiens numb exon 9
<400> 120
cagccuucca ugugcuugcu a                                               21

<210> 121
<211> 21

<212> RNA
<213> Homo sapiens

<220> 121: target regions in region 1+2 of homo sapiens numb exon 9
<400> 121
agccuuccau gugcuugcua a                                               21

<210> 122
<211> 21

<212> RNA
<213> Homo sapiens

<220> 122: target regions in region 1+2 of homo sapiens numb exon 9
<400> 122
gccuuccaug ugcuugcuaa g                                               21

<210> 123
<211> 21

<212> RNA
<213> Homo sapiens

<220> 123: target regions in region 1+2 of homo sapiens numb exon 9
<400> 123
ccuuccaugu gcuugcuaag c                                               21


<210> 124
<211> 7

<212> RNA
<213> Homo sapiens

<220> 124: Target regions in region 4+5 of Homo sapiens Numb exon 9
<400> 124
ccguagc                                                                7

<210> 125
<211> 7

<212> RNA
<213> Homo sapiens

<220> 125: target regions in region 4+5 of homo sapiens numb exon 9
<400> 125
cguagca                                                                7

<210> 126
<211> 7

<212> RNA
<213> Homo sapiens

<220> 126: target regions in region 4+5 of homo sapiens numb exon 9
<400> 126
guagcaa                                                                7

<210> 127
<211> 7

<212> RNA
<213> Homo sapiens

<220> 127: target regions in region 4+5 of homo sapiens numb exon 9
<400> 127
uagcaau                                                                7

<210> 128
<211> 7

<212> RNA
<213> Homo sapiens

<220> 128: target regions in region 4+5 of homo sapiens numb exon 9
<400> 128
agcaaug                                                                7

<210> 129
<211> 7

<212> RNA
<213> Homo sapiens

<220> 129: target regions in region 4+5 of homo sapiens numb exon 9
<400> 129
gcaaugc                                                                7

<210> 130
<211> 7

<212> RNA
<213> Homo sapiens

<220> 130: target regions in region 4+5 of homo sapiens numb exon 9
<400> 130
caaugcc                                                                7

<210> 131
<211> 7

<212> RNA
<213> Homo sapiens

<220> 131: target regions in region 4+5 of homo sapiens numb exon 9
<400> 131
aaugccu                                                                7

<210> 132
<211> 7

<212> RNA
<213> Homo sapiens

<220> 132: target regions in region 4+5 of homo sapiens numb exon 9
<400> 132
augccug                                                                7

<210> 133
<211> 7

<212> RNA
<213> Homo sapiens

<220> 133: target regions in region 4+5 of homo sapiens numb exon 9
<400> 133
ugccugu                                                                7

<210> 134
<211> 7

<212> RNA
<213> Homo sapiens

<220> 134: target regions in region 4+5 of homo sapiens numb exon 9
<400> 134
gccugug                                                                7

<210> 135
<211> 7

<212> RNA
<213> Homo sapiens

<220> 135: target regions in region 4+5 of homo sapiens numb exon 9
<400> 135
ccugugc                                                                7

<210> 136
<211> 7

<212> RNA
<213> Homo sapiens

<220> 136: target regions in region 4+5 of homo sapiens numb exon 9
<400> 136
cugugcg                                                                7

<210> 137
<211> 7

<212> RNA
<213> Homo sapiens

<220> 137: target regions in region 4+5 of homo sapiens numb exon 9
<400> 137
ugugcgu                                                                7

<210> 138
<211> 7

<212> RNA
<213> Homo sapiens

<220> 138: target regions in region 4+5 of homo sapiens numb exon 9
<400> 138
gugcgug                                                                7

<210> 139
<211> 7

<212> RNA
<213> Homo sapiens

<220> 139: target regions in region 4+5 of homo sapiens numb exon 9
<400> 139
ugcguga                                                                7

<210> 140
<211> 7

<212> RNA
<213> Homo sapiens

<220> 140: target regions in region 4+5 of homo sapiens numb exon 9
<400> 140
gcgugaa                                                                7

<210> 141
<211> 7

<212> RNA
<213> Homo sapiens

<220> 141: target regions in region 4+5 of homo sapiens numb exon 9
<400> 141
cgugaaa                                                                7

<210> 142
<211> 7

<212> RNA
<213> Homo sapiens

<220> 142: target regions in region 4+5 of homo sapiens numb exon 9
<400> 142
gugaaac                                                                7

<210> 143
<211> 7

<212> RNA
<213> Homo sapiens

<220> 143: target regions in region 4+5 of homo sapiens numb exon 9
<400> 143
ugaaacc                                                                7

<210> 144
<211> 7

<212> RNA
<213> Homo sapiens

<220> 144: target regions in region 4+5 of homo sapiens numb exon 9
<400> 144
gaaacca                                                                7

<210> 145
<211> 7

<212> RNA
<213> Homo sapiens

<220> 145: target regions in region 4+5 of homo sapiens numb exon 9
<400> 145
aaaccaa                                                                7

<210> 146
<211> 7

<212> RNA
<213> Homo sapiens

<220> 146: target regions in region 4+5 of homo sapiens numb exon 9
<400> 146
aaccaac                                                                7

<210> 147
<211> 7

<212> RNA
<213> Homo sapiens

<220> 147: target regions in region 4+5 of homo sapiens numb exon 9
<400> 147
accaacc                                                                7

<210> 148
<211> 7

<212> RNA
<213> Homo sapiens

<220> 148: target regions in region 4+5 of homo sapiens numb exon 9
<400> 148
ccaaccc                                                                7

<210> 149
<211> 7

<212> RNA
<213> Homo sapiens

<220> 149: target regions in region 4+5 of homo sapiens numb exon 9
<400> 149
caacccu                                                                7

<210> 150
<211> 7

<212> RNA
<213> Homo sapiens

<220> 150: target regions in region 4+5 of homo sapiens numb exon 9
<400> 123
aacccuu                                                                7

<210> 151
<211> 7

<212> RNA
<213> Homo sapiens

<220> 151: target regions in region 4+5 of homo sapiens numb exon 9
<400> 151
acccuug                                                                7

<210> 152
<211> 7

<212> RNA
<213> Homo sapiens

<220> 152: target regions in region 4+5 of homo sapiens numb exon 9
<400> 152
cccuugg                                                                7

<210> 153
<211> 7

<212> RNA
<213> Homo sapiens

<220> 153: target regions in region 4+5 of homo sapiens numb exon 9
<400> 153
ccuuggg                                                                7

<210> 154
<211> 7

<212> RNA
<213> Homo sapiens

<220> 154: target regions in region 4+5 of homo sapiens numb exon 9
<400> 154
cuugggc                                                                7

<210> 155
<211> 7

<212> RNA
<213> Homo sapiens

<220> 155: target regions in region 4+5 of homo sapiens numb exon 9
<400> 155
uugggcc                                                                7

<210> 156
<211> 7

<212> RNA
<213> Homo sapiens

<220> 156: target regions in region 4+5 of homo sapiens numb exon 9
<400> 156
ugggccc                                                                7

<210> 157
<211> 7

<212> RNA
<213> Homo sapiens

<220> 157: target regions in region 4+5 of homo sapiens numb exon 9
<400> 157
gggccca                                                                7

<210> 158
<211> 7

<212> RNA
<213> Homo sapiens

<220> 158: target regions in region 4+5 of homo sapiens numb exon 9
<400> 158
ggcccau                                                                7

<210> 159
<211> 7

<212> RNA
<213> Homo sapiens

<220> 159: target regions in region 4+5 of homo sapiens numb exon 9
<400> 159
gcccaug                                                                7


<210> 160
<211> 13

<212> RNA
<213> Homo sapiens

<220> 160: target regions in region 4+5 of  homo sapiens numb exon 9
<400> 160
ccguagcaau gcc                                                        13

<210> 161
<211> 13

<212> RNA
<213> Homo sapiens

<220> 161: target regions in region 4+5 of homo sapiens numb exon 9
<400> 161
cguagcaaug ccu                                                        13

<210> 162
<211> 13

<212> RNA
<213> Homo sapiens

<220> 162: target regions in region 4+5 of homo sapiens numb exon 9
<400> 162
guagcaaugc cug                                                        13

<210> 163
<211> 13

<212> RNA
<213> Homo sapiens

<220> 163: target regions in region 4+5 of homo sapiens numb exon 9
<400> 163
uagcaaugcc ugu                                                        13

<210> 164
<211> 13

<212> RNA
<213> Homo sapiens

<220> 164: target regions in region 4+5 of homo sapiens numb exon 9
<400> 164
agcaaugccu gug                                                        13

<210> 165
<211> 13

<212> RNA
<213> Homo sapiens

<220> 165: target regions in region 4+5 of homo sapiens numb exon 9
<400> 165
gcaaugccug ugc                                                        13

<210> 166
<211> 13

<212> RNA
<213> Homo sapiens

<220> 166: target regions in region 4+5 of homo sapiens numb exon 9
<400> 166
caaugccugu gcg                                                        13

<210> 167
<211> 13

<212> RNA
<213> Homo sapiens

<220> 167: target regions in region 4+5 of homo sapiens numb exon 9
<400> 167
aaugccugug cgu                                                        13

<210> 168
<211> 13

<212> RNA
<213> Homo sapiens

<220> 168: target regions in region 4+5 of homo sapiens numb exon 9
<400> 168
augccugugcgug                                                         13

<210> 169
<211> 13

<212> RNA
<213> Homo sapiens

<220> 169: target regions in region 4+5 of homo sapiens numb exon 9
<400> 169
ugccugugcg uga                                                        13

<210> 170
<211> 13

<212> RNA
<213> Homo sapiens

<220> 170: target regions in region 4+5 of homo sapiens numb exon 9
<400> 170
gccugugcgu gaa                                                        13

<210> 171
<211> 13

<212> RNA
<213> Homo sapiens

<220> 171: target regions in region 4+5 of homo sapiens numb exon 9
<400> 171
ccugugcgug aaa                                                        13

<210> 172
<211> 13

<212> RNA
<213> Homo sapiens

<220> 172: target regions in region 4+5 of homo sapiens numb exon 9
<400> 172
cugugcguga aac                                                        13

<210> 173
<211> 13

<212> RNA
<213> Homo sapiens

<220> 173: target regions in region 4+5 of homo sapiens numb exon 9
<400> 173
ugugcgugaa acc                                                        13

<210> 174
<211> 13

<212> RNA
<213> Homo sapiens

<220> 174: target regions in region 4+5 of homo sapiens numb exon 9
<400> 174
gugcgugaaa cca                                                        13

<210> 175
<211> 13

<212> RNA
<213> Homo sapiens

<220> 175: target regions in region 4+5 of homo sapiens numb exon 9
<400> 175
ugcgugaaac caa                                                        13

<210> 176
<211> 13

<212> RNA
<213> Homo sapiens

<220> 176: target regions in region 4+5 of homo sapiens numb exon 9
<400> 176
gcgugaaacc aac                                                        13

<210> 177
<211> 13

<212> RNA
<213> Homo sapiens

<220> 177: target regions in region 4+5 of homo sapiens numb exon 9
<400> 177
cgugaaacca acc                                                        13

<210> 178
<211> 13

<212> RNA
<213> Homo sapiens

<220> 178: target regions in region 4+5 of homo sapiens numb exon 9
<400> 178
gugaaaccaa ccc                                                        13

<210> 179
<211> 13

<212> RNA
<213> Homo sapiens

<220> 179: target regions in region 4+5 of homo sapiens numb exon 9
<400> 179
ugaaaccaac ccu                                                        13

<210> 180
<211> 13

<212> RNA
<213> Homo sapiens

<220> 180: target regions in region 4+5 of homo sapiens numb exon 9
<400> 180
gaaaccaacc cuu                                                        13

<210> 181
<211> 13

<212> RNA
<213> Homo sapiens

<220> 181: target regions in region 4+5 of homo sapiens numb exon 9
<400> 181
aaaccaaccc uug                                                        13

<210> 182
<211> 13

<212> RNA
<213> Homo sapiens

<220> 182: target regions in region 4+5 of homo sapiens numb exon 9
<400> 182
aaccaacccu ugg                                                        13

<210> 183
<211> 13

<212> RNA
<213> Homo sapiens

<220> 183: target regions in region 4+5 of homo sapiens numb exon 9
<400> 183
accaacccuu ggg                                                        13

<210> 184
<211> 13

<212> RNA
<213> Homo sapiens

<220> 184: target regions in region 4+5 of homo sapiens numb exon 9
<400> 184
ccaacccuug ggc                                                        13

<210> 185
<211> 13

<212> RNA
<213> Homo sapiens

<220> 185: target regions in region 4+5 of homo sapiens numb exon 9
<400> 185
caacccuugg gcc                                                        13

<210> 186
<211> 13

<212> RNA
<213> Homo sapiens

<220> 186: target regions in region 4+5 of homo sapiens numb exon 9
<400> 186
aacccuuggg ccc                                                        13

<210> 187
<211> 13

<212> RNA
<213> Homo sapiens

<220> 187: target regions in region 4+5 of homo sapiens numb exon 9
<400> 187
acccuugggc cca                                                        13

<210> 188
<211> 13

<212> RNA
<213> Homo sapiens

<220> 188: target regions in region 4+5 of homo sapiens numb exon 9
<400> 188
cccuugggcc cau                                                        13

<210> 189
<211> 13

<212> RNA
<213> Homo sapiens

<220> 189: target regions in region 4+5 of homo sapiens numb exon 9
<400> 189
ccuugggccc aug                                                        13

<210> 190
<211> 21

<212> RNA
<213> Homo sapiens

<220> 190: target regions in region 4+5 of homo sapiens numb exon 9
<400> 190
ccguagcaau gccugugcgu g                                               21

<210> 191
<211> 21

<212> RNA
<213> Homo sapiens

<220> 191: target regions in region 4+5 of homo sapiens numb exon 9
<400> 191
cguagcaaug ccugugcgug a                                               21

<210> 192
<211> 21

<212> RNA
<213> Homo sapiens

<220> 192: target regions in region 4+5 of homo sapiens numb exon 9
<400> 192
guagcaaugc cugugcguga a                                               21

<210> 193
<211> 21

<212> RNA
<213> Homo sapiens

<220> 193: target regions in region 4+5 of homo sapiens numb exon 9
<400> 193
uagcaaugcc ugugcgugaa a                                               21

<210> 194
<211> 21

<212> RNA
<213> Homo sapiens

<220> 194: target regions in region 4+5 of homo sapiens numb exon 9
<400> 194
agcaaugccu gugcgugaaa c                                               21

<210> 195
<211> 21

<212> RNA
<213> Homo sapiens

<220> 195: target regions in region 4+5 of homo sapiens numb exon 9
<400> 195
gcaaugccug ugcgugaaac c                                               21

<210> 196
<211> 21

<212> RNA
<213> Homo sapiens

<220> 196: target regions in region 4+5 of homo sapiens numb exon 9
<400> 196
caaugccugu gcgugaaacc a                                               21

<210> 197
<211> 21

<212> RNA
<213> Homo sapiens

<220> 197: target regions in region 4+5 of homo sapiens numb exon 9
<400> 197
aaugccugug cgugaaacca a                                               21

<210> 198
<211> 21

<212> RNA
<213> Homo sapiens

<220> 198: target regions in region 4+5 of homo sapiens numb exon 9
<400> 198
augccugugc gugaaaccaa c                                               21

<210> 199
<211> 21

<212> RNA
<213> Homo sapiens

<220> 199: target regions in region 4+5 of homo sapiens numb exon 9
<400> 199
ugccugugcg ugaaaccaac c                                               21

<210> 200
<211> 21

<212> RNA
<213> Homo sapiens

<220> 200: target regions in region 4+5 of homo sapiens numb exon 9
<400> 200
gccugugcgu gaaaccaacc c                                               21

<210> 201
<211> 21

<212> RNA
<213> Homo sapiens

<220> 201: target regions in region 4+5 of homo sapiens numb exon 9
<400> 201
ccugugcgug aaaccaaccc u                                               21

<210> 202
<211> 21

<212> RNA
<213> Homo sapiens

<220> 202: target regions in region 4+5 of homo sapiens numb exon 9
<400> 202
cugugcguga aaccaacccu u                                               21

<210> 203
<211> 21

<212> RNA
<213> Homo sapiens

<220> 203: target regions in region 4+5 of homo sapiens numb exon 9
<400> 203
ugugcgugaa accaacccuu g                                               21

<210> 204
<211> 21

<212> RNA
<213> Homo sapiens

<220> 204: target regions in region 4+5 of homo sapiens numb exon 9
<400> 204
gugcgugaaa ccaacccuug g                                               21

<210> 205
<211> 21

<212> RNA
<213> Homo sapiens

<220> 205: target regions in region 4+5 of homo sapiens numb exon 9
<400> 205
ugcgugaaac caacccuugg g                                               21

<210> 206
<211> 21

<212> RNA
<213> Homo sapiens

<220> 206: target regions in region 4+5 of homo sapiens numb exon 9
<400> 206
gcgugaaacc aacccuuggg c                                               21

<210> 207
<211> 21

<212> RNA
<213> Homo sapiens

<220> 207: target regions in region 4+5 of homo sapiens numb exon 9
<400> 207
cgugaaacca acccuugggc c                                               21

<210> 208
<211> 21

<212> RNA
<213> Homo sapiens

<220> 208: target regions in region 4+5 of homo sapiens numb exon 9
<400> 208
gugaaaccaa cccuugggcc c                                               21

<210> 209
<211> 21

<212> RNA
<213> Homo sapiens

<220> 209: target regions in region 4+5 of homo sapiens numb exon 9
<400> 209
ugaaaccaac ccuugggccc a                                               21

<210> 210
<211> 21

<212> RNA
<213> Homo sapiens

<220> 210: target regions in region 4+5 of homo sapiens numb exon 9
<400> 210
gaaaccaacc cuugggccca u                                               21

<210> 211
<211> 21

<212> RNA
<213> Homo sapiens

<220> 211: target regions in region 4+5 of homo sapiens numb exon 9
<400> 211
aaaccaaccc uugggcccau g                                               21

<210> 212
<211> 7

<212> RNA
<213> Homo sapiens

<220> 212: target regions in region 6+7 of homo sapiens numb exon 9
<400> 212
ccccuga                                                                7

<210> 213
<211> 7

<212> RNA
<213> Homo sapiens

<220> 213: target regions in region 6+7 of homo sapiens numb exon 9
<400> 213
cccugau                                                                7

<210> 214
<211> 7

<212> RNA
<213> Homo sapiens

<220> 214: target regions in region 6+7 of homo sapiens numb exon 9
<400> 214
ccugaug                                                                7

<210> 215
<211> 7

<212> RNA
<213> Homo sapiens

<220> 215: target regions in region 6+7 of homo sapiens numb exon 9
<400> 215
cugaugc                                                                7

<210> 216
<211> 7

<212> RNA
<213> Homo sapiens

<220> 216: target regions in region 6+7 of homo sapiens numb exon 9
<400> 216
ugaugcu                                                                7

<210> 217
<211> 7

<212> RNA
<213> Homo sapiens

<220> 217: target regions in region 6+7 of homo sapiens numb exon 9
<400> 217
gaugcug                                                                7

<210> 218
<211> 7

<212> RNA
<213> Homo sapiens

<220> 218: target regions in region 6+7 of homo sapiens numb exon 9
<400> 218
augcugc                                                                7

<210> 219
<211> 7

<212> RNA
<213> Homo sapiens

<220> 219: target regions in region 6+7 of homo sapiens numb exon 9
<400> 219
ugcugcu                                                                7

<210> 220
<211> 7

<212> RNA
<213> Homo sapiens

<220> 220: target regions in region 6+7 of homo sapiens numb exon 9
<400> 220
gcugcua                                                                7

<210> 221
<211> 7

<212> RNA
<213> Homo sapiens

<220> 221: target regions in region 6+7 of homo sapiens numb exon 9
<400> 221
cugcuaa                                                                7

<210> 222
<211> 7

<212> RNA
<213> Homo sapiens

<220> 222: target regions in region 6+7 of homo sapiens numb exon 9
<400> 222
ugcuaac                                                                7

<210> 223
<211> 7

<212> RNA
<213> Homo sapiens

<220> 223: target regions in region 6+7 of homo sapiens numb exon 9
<400> 223
gcuaaca                                                                7

<210> 224
<211> 7

<212> RNA
<213> Homo sapiens

<220> 224: target regions in region 6+7 of homo sapiens numb exon 9
<400> 224
cuaacaa                                                                7

<210> 225
<211> 7

<212> RNA
<213> Homo sapiens

<220> 225: target regions in region 6+7 of homo sapiens numb exon 9
<400> 225
uaacaag                                                                7

<210> 226
<211> 7

<212> RNA
<213> Homo sapiens

<220> 226: target regions in region 6+7 of homo sapiens numb exon 9
<400> 226
aacaagg                                                                7

<210> 227
<211> 7

<212> RNA
<213> Homo sapiens

<220> 227: target regions in region 6+7 of homo sapiens numb exon 9
<400> 227
acaagga                                                                7

<210> 228
<211> 7

<212> RNA
<213> Homo sapiens

<220> 228: target regions in region 6+7 of homo sapiens numb exon 9
<400> 228
caaggaa                                                                7

<210> 229
<211> 7

<212> RNA
<213> Homo sapiens

<220> 229: target regions in region 6+7 of homo sapiens numb exon 9
<400> 229
aaggaaa                                                                7

<210> 230
<211> 7

<212> RNA
<213> Homo sapiens

<220> 230: target regions in region 6+7 of homo sapiens numb exon 9
<400> 230
aggaaau                                                                7

<210> 231
<211> 7

<212> RNA
<213> Homo sapiens

<220> 231: target regions in region 6+7 of homo sapiens numb exon 9
<400> 231
ggaaauu                                                                7

<210> 232
<211> 7

<212> RNA
<213> Homo sapiens

<220> 232: target regions in region 6+7 of homo sapiens numb exon 9
<400> 232
gaaauug                                                                7

<210> 233
<211> 7

<212> RNA
<213> Homo sapiens

<220> 233: target regions in region 6+7 of homo sapiens numb exon 9
<400> 233
aaauugc                                                                7

<210> 214
<211> 7

<212> RNA
<213> Homo sapiens

<220> 234: target regions in region 6+7 of homo sapiens numb exon 9
<400> 234
aauugca                                                                7

<210> 235
<211> 7

<212> RNA
<213> Homo sapiens

<220> 235: target regions in region 6+7 of homo sapiens numb exon 9
<400> 235
auugcag                                                                7

<210> 236
<211> 7

<212> RNA
<213> Homo sapiens

<220> 236: target regions in region 6+7 of homo sapiens numb exon 9
<400> 236
uugcagc                                                                7

<210> 237
<211> 7

<212> RNA
<213> Homo sapiens

<220> 237: target regions in region 6+7 of homo sapiens numb exon 9
<400> 237
ugcagcc                                                                7

<210> 238
<211> 7

<212> RNA
<213> Homo sapiens

<220> 238: target regions in region 6+7 of homo sapiens numb exon 9
<400> 238
gcagcca                                                                7

<210> 239
<211> 7

<212> RNA
<213> Homo sapiens

<220> 239: target regions in region 6+7 of homo sapiens numb exon 9
<400> 239
cagccac                                                                7

<210> 240
<211> 7

<212> RNA
<213> Homo sapiens

<220> 240: target regions in region 6+7 of homo sapiens numb exon 9
<400> 240
agccaca                                                                7

<210> 241
<211> 7

<212> RNA
<213> Homo sapiens

<220> 241: target regions in region 6+7 of homo sapiens numb exon 9
<400> 241
gccacau                                                                7

<210> 242
<211> 7

<212> RNA
<213> Homo sapiens

<220> 242: target regions in region 6+7 of homo sapiens numb exon 9
<400> 242
ccacaug                                                                7

<210> 243
<211> 7

<212> RNA
<213> Homo sapiens

<220> 243: target regions in region 6+7 of homo sapiens numb exon 9
<400> 243
cacaugu                                                                7

<210> 244
<211> 7

<212> RNA
<213> Homo sapiens

<220> 244: target regions in region 6+7 of homo sapiens numb exon 9
<400> 244
acauguu                                                                7

<210> 245
<211> 7

<212> RNA
<213> Homo sapiens

<220> 245: target regions in region 6+7 of homo sapiens numb exon 9
<400> 245
cauguuc                                                                7

<210> 246
<211> 7

<212> RNA
<213> Homo sapiens

<220> 246: target regions in region 6+7 of homo sapiens numb exon 9
<400> 246
auguucg                                                                7

<210> 247
<211> 7

<212> RNA
<213> Homo sapiens

<220> 247: target regions in region 6+7 of homo sapiens numb exon 9
<400> 247
uguucgg                                                                7

<210> 248
<211> 13

<212> RNA
<213> Homo sapiens

<220> 248: target regions in region 6+7 of homo sapiens numb exon 9
<400> 248
ccccugaugc ugc                                                        13

<210> 249
<211> 13

<212> RNA
<213> Homo sapiens

<220> 249: target regions in region 6+7 of homo sapiens numb exon 9
<400> 249
cccugaugcu gcu                                                        13

<210> 250
<211> 13

<212> RNA
<213> Homo sapiens

<220> 250: target regions in region 6+7 of homo sapiens numb exon 9
<400> 250
ccugaugcug cua                                                        13

<210> 251
<211> 13

<212> RNA
<213> Homo sapiens

<220> 251: target regions in region 6+7 of homo sapiens numb exon 9
<400> 251
cugaugcugc uaa                                                        13

<210> 252
<211> 13

<212> RNA
<213> Homo sapiens

<220> 252: target regions in region 6+7 of homo sapiens numb exon 9
<400> 252
ugaugcugcu aac                                                        13

<210> 253
<211> 13

<212> RNA
<213> Homo sapiens

<220> 253: target regions in region 6+7 of homo sapiens numb exon 9
<400> 253
gaugcugcua aca                                                        13

<210> 254
<211> 13

<212> RNA
<213> Homo sapiens

<220> 254: target regions in region 6+7 of homo sapiens numb exon 9
<400> 254
augcugcuaa caa                                                        13

<210> 255
<211> 13

<212> RNA
<213> Homo sapiens

<220> 255: target regions in region 6+7 of homo sapiens numb exon 9
<400> 255
ugcugcuaac aag                                                        13

<210> 256
<211> 13

<212> RNA
<213> Homo sapiens

<220> 256: target regions in region 6+7 of homo sapiens numb exon 9
<400> 256
gcugcuaaca agg                                                        13

<210> 257
<211> 13

<212> RNA
<213> Homo sapiens

<220> 257: target regions in region 6+7 of homo sapiens numb exon 9
<400> 257
cugcuaacaa gga                                                        13

<210> 258
<211> 13

<212> RNA
<213> Homo sapiens

<220> 258: target regions in region 6+7 of homo sapiens numb exon 9
<400> 258
ugcuaacaag gaa                                                        13

<210> 259
<211> 13

<212> RNA
<213> Homo sapiens

<220> 259: target regions in region 6+7 of homo sapiens numb exon 9
<400> 259
gcuaacaagg aaa                                                        13

<210> 260
<211> 13

<212> RNA
<213> Homo sapiens

<220> 260: target regions in region 6+7 of homo sapiens numb exon 9
<400> 260
cuaacaagga aau                                                        13

<210> 261
<211> 13

<212> RNA
<213> Homo sapiens

<220> 261: target regions in region 6+7 of homo sapiens numb exon 9
<400> 261
uaacaaggaa auu                                                        13

<210> 262
<211> 13

<212> RNA
<213> Homo sapiens

<220> 262: target regions in region 6+7 of homo sapiens numb exon 9
<400> 262
aacaaggaaa uug                                                        13

<210> 263
<211> 13

<212> RNA
<213> Homo sapiens

<220> 263: target regions in region 6+7 of homo sapiens numb exon 9
<400> 263
acaaggaaau ugc                                                        13

<210> 264
<211> 13

<212> RNA
<213> Homo sapiens

<220> 264: target regions in region 6+7 of homo sapiens numb exon 9
<400> 264
caaggaaauu gca                                                        13

<210> 265
<211> 13

<212> RNA
<213> Homo sapiens

<220> 265: target regions in region 6+7 of homo sapiens numb exon 9
<400> 265
aaggaaauug cag                                                        13

<210> 266
<211> 13

<212> RNA
<213> Homo sapiens

<220> 266: target regions in region 6+7 of homo sapiens numb exon 9
<400> 266
aggaaauugc agc                                                        13

<210> 267
<211> 13

<212> RNA
<213> Homo sapiens

<220> 267: target regions in region 6+7 of homo sapiens numb exon 9
<400> 267
ggaaauugca gcc                                                        13

<210> 268
<211> 13

<212> RNA
<213> Homo sapiens

<220> 268: target regions in region 6+7 of homo sapiens numb exon 9
<400> 268
gaaauugcag cca                                                        13

<210> 269
<211> 13

<212> RNA
<213> Homo sapiens

<220> 269: target regions in region 6+7 of homo sapiens numb exon 9
<400> 269
aaauugcagc cac                                                        13

<210> 270
<211> 13

<212> RNA
<213> Homo sapiens

<220> 270: target regions in region 6+7 of homo sapiens numb exon 9
<400> 270
aauugcagcc aca                                                        13

<210> 271
<211> 13

<212> RNA
<213> Homo sapiens

<220> 271: target regions in region 6+7 of homo sapiens numb exon 9
<400> 271
auugcagcca cau                                                        13

<210> 272
<211> 13

<212> RNA
<213> Homo sapiens

<220> 272: target regions in region 6+7 of homo sapiens numb exon 9
<400> 272
uugcagccac aug                                                        13

<210> 273
<211> 13

<212> RNA
<213> Homo sapiens

<220> 273: target regions in region 6+7 of homo sapiens numb exon 9
<400> 273
ugcagccaca ugu                                                        13

<210> 274
<211> 13

<212> RNA
<213> Homo sapiens

<220> 274: target regions in region 6+7 of homo sapiens numb exon 9
<400> 274
gcagccacau guu                                                        13

<210> 275
<211> 13

<212> RNA
<213> Homo sapiens

<220> 275: target regions in region 6+7 of homo sapiens numb exon 9
<400> 275
cagccacaug uuc                                                        13

<210> 276
<211> 13

<212> RNA
<213> Homo sapiens

<220> 276: target regions in region 6+7 of homo sapiens numb exon 9
<400> 276
agccacaugu ucg                                                        13

<210> 277
<211> 13

<212> RNA
<213> Homo sapiens

<220> 277: target regions in region 6+7 of homo sapiens numb exon 9
<400> 277
gccacauguu cgg                                                        13

<210> 278
<211> 21

<212> RNA
<213> Homo sapiens

<220> 278: target regions in region 6+7 of homo sapiens numb exon 9
<400> 278
ccccugaugc ugcuaacaag g                                               21

<210> 279
<211> 21

<212> RNA
<213> Homo sapiens

<220> 279: target regions in region 6+7 of homo sapiens numb exon 9
<400> 279
cccugaugcu gcuaacaagg a                                               21

<210> 280
<211> 21

<212> RNA
<213> Homo sapiens

<220> 280: target regions in region 6+7 of homo sapiens numb exon 9
<400> 280
ccugaugcug cuaacaagga a                                               21

<210> 281
<211> 21

<212> RNA
<213> Homo sapiens

<220> 281: target regions in region 6+7 of homo sapiens numb exon 9
<400> 281
cugaugcugc uaacaaggaa a                                               21

<210> 282
<211> 21

<212> RNA
<213> Homo sapiens

<220> 282: target regions in region 6+7 of homo sapiens numb exon 9
<400> 282
ugaugcugcu aacaaggaaa u                                               21

<210> 283
<211> 21

<212> RNA
<213> Homo sapiens

<220> 283: target regions in region 6+7 of homo sapiens numb exon 9
<400> 293
gaugcugcua acaaggaaau u                                               21

<210> 284
<211> 21

<212> RNA
<213> Homo sapiens

<220> 284: target regions in region 6+7 of homo sapiens numb exon 9
<400> 284
augcugcuaa caaggaaauu g                                               21

<210> 285
<211> 21

<212> RNA
<213> Homo sapiens

<220> 285: target regions in region 6+7 of homo sapiens numb exon 9
<400> 285
ugcugcuaac aaggaaauug c                                               21

<210> 286
<211> 21

<212> RNA
<213> Homo sapiens

<220> 286: target regions in region 6+7 of homo sapiens numb exon 9
<400> 286
gcugcuaaca aggaaauugc a                                               21

<210> 287
<211> 21

<212> RNA
<213> Homo sapiens

<220> 287: target regions in region 6+7 of homo sapiens numb exon 9
<400> 287
cugcuaacaa ggaaauugca g                                               21

<210> 288
<211> 21

<212> RNA
<213> Homo sapiens

<220> 288: target regions in region 6+7 of homo sapiens numb exon 9
<400> 288
ugcuaacaag gaaauugcag c                                               21

<210> 289
<211> 21

<212> RNA
<213> Homo sapiens

<220> 289: target regions in region 6+7 of homo sapiens numb exon 9
<400> 289
gcuaacaagg aaauugcagc c                                               21

<210> 290
<211> 21

<212> RNA
<213> Homo sapiens

<220> 290: target regions in region 6+7 of homo sapiens numb exon 9
<400> 290
cuaacaagga aauugcagcc a                                               21

<210> 291
<211> 21

<212> RNA
<213> Homo sapiens

<220> 291: target regions in region 6+7 of homo sapiens numb exon 9
<400> 291
uaacaaggaa auugcagcca c                                               21

<210> 292
<211> 21

<212> RNA
<213> Homo sapiens

<220> 292: target regions in region 6+7 of homo sapiens numb exon 9
<400> 292
aacaaggaaa uugcagccac a                                               21

<210> 293
<211> 21

<212> RNA
<213> Homo sapiens

<220> 293: target regions in region 6+7 of homo sapiens numb exon 9
<400> 293
acaaggaaau ugcagccaca u                                               21

<210> 294
<211> 21

<212> RNA
<213> Homo sapiens

<220> 294: target regions in region 6+7 of homo sapiens numb exon 9
<400> 294
caaggaaau ugcagccacau g                                               21

<210> 295
<211> 21

<212> RNA
<213> Homo sapiens

<220> 295: target regions in region 6+7 of homo sapiens numb exon 9
<400> 295
aaggaaauu gcagccacaug u                                               21

<210> 296
<211> 21

<212> RNA
<213> Homo sapiens

<220> 296: target regions in region 6+7 of homo sapiens numb exon 9
<400> 296
aggaaauug cagccacaugu u                                               21

<210> 297
<211> 21

<212> RNA
<213> Homo sapiens

<220> 297: target regions in region 6+7 of homo sapiens numb exon 9
<400> 297
ggaaauugc agccacauguu c                                               21

<210> 298
<211> 21

<212> RNA
<213> Homo sapiens

<220> 298: target regions in region 6+7 of homo sapiens numb exon 9
<400> 298
gaaauugcag ccacauguuc g                                               21

<210> 299
<211> 21

<212> RNA
<213> Homo sapiens

<220> 299: target regions in region 6+7 of homo sapiens numb exon 9
<400> 299
aaauugcagc cacauguucg g                                               21

<210> 300
<211> 11
<212> DNA
<213> Homo sapiens

<220> 
<223> Potential binding site of SF1/BBP in NUMB exon 9

<400> 300
ggcactgact c                                                          11

<210> 301
<211> 11
<212> DNA
<213> Artificial Sequence

<220> 
<223> RG6-NUMB minigene WT

<400> 301
ggcactgact c                                                          11

<210> 302
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> RG6-NUMB minigene Mut3

<400> 302
ggcactcacc tc                                                         12

<210> 303
<211> 11
<212> DNA
<213> Artificial Sequence

<220> 
<223> RG6-NUMB minigene Mut 4

<400> 303
ggcaccgact c                                                          11

<210> 304
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> RG6-NUMB minigene Mut 1

<400> 304
ggtactgacc tc                                                         12

<210> 305
<211> 50
<212> RNA
<213> Homo sapiens

<220> 
<223> Region 1+2+ 2-3 of Homo sapiens Numb exon 9 (targeted by by AON1 – SEQ ID NO: 12; AON2 SEQ ID NO: 13; AON1-2 – SEQ ID NO: 19; and AON2-3 – SEQ ID NO:20) 

<400> 305
cuaauggcac ugacucagcc uuccaugugc uugcuaagcc agcccauacu                50

<210> 306
<211> 7

<212> RNA
<213> Homo sapiens

<220> 
<223> 306: Target regions in region 1+2+2-3  of  Homo sapiens Numb exon 9
<400> 306
cuaagcc                                                                7

<210> 307
<211> 7

<212> RNA
<213> Homo sapiens

<220> 307: Target regions in region 1+2+2-3 of  Homo sapiens Numb exon 9

<400> 307
uaagcca                                                                7

<210> 308
<211> 7

<212> RNA
<213> Homo sapiens

<220> 308: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 308
aagccag                                                                7

<210> 309
<211> 7

<212> RNA
<213> Homo sapiens

<220> 309: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 309
agccagc                                                                7

<210> 310
<211> 7

<212> RNA
<213> Homo sapiens

<220> 310: target regions in region 1+2+2-3 of  homo sapiens numb exon 9

<400> 310
gccagcc                                                                7

<210> 311
<211> 7

<212> RNA
<213> Homo sapiens

<220> 311: target regions in region 1+2+2-3 of  homo sapiens numb exon 9

<400> 311
ccagccc                                                                7

<210> 312
<211> 7

<212> RNA
<213> Homo sapiens

<220> 312: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 312
cagccca                                                                7

<210> 313
<211> 7

<212> RNA
<213> Homo sapiens

<220> 313: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 313
agcccau                                                                7

<210> 314
<211> 7

<212> RNA
<213> Homo sapiens

<220> 314: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 314
gcccaua                                                                7

<210> 315
<211> 7

<212> RNA
<213> Homo sapiens

<220> 315: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 315
cccauac                                                                7

<210> 316
<211> 7

<212> RNA
<213> Homo sapiens

<220> 316: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 316
ccauacu                                                                7

<210> 317
<211> 13

<212> RNA
<213> Homo sapiens

<220> 317: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 317
ugcuugcuaa gcc                                                        13

<210> 318
<211> 13

<212> RNA
<213> Homo sapiens

<220> 318: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 318
gcuugcuaag cca                                                        13

<210> 319
<211> 13

<212> RNA
<213> Homo sapiens

<220> 319: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 319
cuugcuaagc cag                                                        13

<210> 320
<211> 13

<212> RNA
<213> Homo sapiens

<220> 320: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 320
uugcuaagcc agc                                                        13

<210> 321
<211> 13

<212> RNA
<213> Homo sapiens

<220> 321: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 321
ugcuaagcca gcc                                                        13

<210> 322
<211> 13

<212> RNA
<213> Homo sapiens

<220> 322: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 322
gcuaagccag ccc                                                        13

<210> 323
<211> 13

<212> RNA
<213> Homo sapiens

<220> 323: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 323
cuaagccagc cca                                                        13

<210> 324
<211> 13

<212> RNA
<213> Homo sapiens

<220> 324: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 324
uaagccagcc cau                                                        13

<210> 325
<211> 13

<212> RNA
<213> Homo sapiens

<220> 325: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 325
aagccagccc aua                                                        13

<210> 326
<211> 13

<212> RNA
<213> Homo sapiens

<220> 326: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 326
agccagccca uac                                                        13

<210> 327
<211> 13

<212> RNA
<213> Homo sapiens

<220> 327: target regions in region 1+2+2-3 of  homo sapiens numb exon 9
<400> 327
gccagcccau acu                                                        13

<210> 328
<211> 21

<212> RNA
<213> Homo sapiens

<220> 328: target regions in region 1+2+2-3 of homo sapiens numb exon 9
<400> 328
cuuccaugug cuugcuaagc c                                               21

<210> 329
<211> 21

<212> RNA
<213> Homo sapiens

<220> 329: target regions in region 1+2+2-3 of homo sapiens numb exon 9
<400> 329
uuccaugugc uugcuaagcc a                                               21

<210> 330
<211> 21

<212> RNA
<213> Homo sapiens

<220> 330: target regions in region 1+2+2-3 of homo sapiens numb exon 9
<400> 330
uccaugugcu ugcuaagcca g                                               21

<210> 331
<211> 21

<212> RNA
<213> Homo sapiens

<220> 331: target regions in region 1+2+2-3 of homo sapiens numb exon 9
<400> 331
ccaugugcuu gcuaagccag c                                               21

<210> 332
<211> 21

<212> RNA
<213> Homo sapiens

<220> 332: target regions in region 1+2+2-3 of homo sapiens numb exon 9
<400> 332
caugugcuug cuaagccagc c                                               21

<210> 333
<211> 21

<212> RNA
<213> Homo sapiens

<220> 333: target regions in region 1+2+2-3 of homo sapiens numb exon 9
<400> 333
augugcuugc uaagccagcc c                                               21

<210> 334
<211> 21

<212> RNA
<213> Homo sapiens

<220> 334: target regions in region 1+2+2-3 of homo sapiens numb exon 9
<400> 334
ugugcuugcu aagccagccc a                                               21

<210> 335
<211> 21

<212> RNA
<213> Homo sapiens

<220> 335: target regions in region 1+2+2-3 of homo sapiens numb exon 9
<400> 335
gugcuugcua agccagccca u                                               21

<210> 336
<211> 21

<212> RNA
<213> Homo sapiens

<220> 336: target regions in region 1+2+2-3 of homo sapiens numb exon 9
<400> 336
ugcuugcuaa gccagcccau a                                               21

<210> 337
<211> 21

<212> RNA
<213> Homo sapiens

<220> 337: target regions in region 1+2+2-3 of homo sapiens numb exon 9
<400> 337
gcuugcuaag ccagcccaua c                                               21

<210> 338
<211> 21

<212> RNA
<213> Homo sapiens

<220> 338: target regions in region 1+2+2-3 of homo sapiens numb exon 9
<400> 338
cuugcuaagc cagcccauac u                                               21


<210> 339
<211> 14

<212> RNA
<213> Homo sapiens

<220> 339: Antisense oligonucleotide targeting Region 1 of Homo sapiens Numb exon 9 – 14 nt long, targeting second part of region defined by SEQ ID NO:44
<400> 339
aggcugaguc agug                                                       14


<210> 340
<211> 14

<212> RNA
<213> Homo sapiens

<220> 340: Antisense oligonucleotide targeting Region 1 of Homo sapiens Numb exon 9 – 14 nt long, targeting firstpart of region defined by SEQ ID NO:44
<400> 340
gucagugcca uuag                                                       14

<210> 341
<211> 14

<212> RNA
<213> Homo sapiens

<220> 341: Homo sapiens Numb exon 9 sequence targeted by antisense oligonucleotide of SEQ ID NO: 339 
<400> 341
cacugacuca gccu                                                       14


<210> 342
<211> 14

<212> RNA
<213> Homo sapiens

<220> 342: Homo sapiens Numb exon 9 sequence targeted by antisense oligonucleotide of SEQ ID NO: 340 
<400> 342
cuaauggcac ugac                                                       14

<210> 343
<211> 14

<212> RNA
<213> Artificial Sequence

<220> 343: Random oligonucleotide – 14 nt long
<400> 343
aaaccgcgcg uacg                                                      14

<210> 344
<211> 7

<212> RNA
<213> Homo sapiens

<220> 344: Antisense oligonucleotide targeting SEQ ID NO:59  in Region 1 of Homo sapiens Numb exon 9 – 7 nt long 
<400> 344
aggcuga                                                                7

<210> 345
<211> 7

<212> RNA
<213> Homo sapiens

<220> 345: Antisense oligonucleotide targeting SEQ ID NO:56  in Region 1 of Homo sapiens Numb exon 9 – 7 nt long 
<400> 345
cugaguc                                                                7

<210> 346
<211> 7


<212> RNA
<213> Homo sapiens

<220> 346: Antisense oligonucleotide targeting SEQ ID NO: 52 in Region 1 of Homo sapiens Numb exon 9 – 7 nt long 
<400> 346
gucagug                                                                7

<210> 315
<211> 7

<212> RNA
<213> Homo sapiens

<220> 347: Antisense oligonucleotide targeting SEQ ID NO:49  in Region 1 of Homo sapiens Numb exon 9 – 7 nt long 
<400> 347
agugcca                                                                7

<210> 348
<211> 7


<212> RNA
<213> Homo sapiens

<220> 348: Antisense oligonucleotide targeting SEQ ID NO: 45 in Region 1 of Homo sapiens Numb exon 9 – 7 nt long 
<400> 348
ccauuag                                                                7

<210> 349
<211> 21

<212> RNA
<213> Artificial Sequence

<220> 349: Random oligonucleotide – 21 nt long
<400> 349
aaccgcgcgu acgaaaccgu c                                               21

<210> 350
<211> 21

<212> RNA
<213> Homo sapiens

<220> 350: Antisense oligonucleotide targeting SEQ ID NO: 117 in Region 1+2+2-3 of Homo sapiens Numb exon 9 – 21 nt long 
<400> 350
caagcacaug gaaggcugag u                                               21

<210> 51
<211> 21

<212> RNA
<213> Homo sapiens

<220> 351: Antisense oligonucleotide targeting SEQ ID NO: 121 in Region 1+2+2-3 of Homo sapiens Numb exon 9 – 21 nt long 
<400> 351
uuagcaagca cauggaaggc u                                               21

<210> 352
<211> 21

<212> RNA
<213> Homo sapiens

<220> 352: Antisense oligonucleotide targeting SEQ ID NO: 331  in Region 1+2+2-3 of Homo sapiens Numb exon 9 – 21 nt long 
<400> 352
gcuggcuuag caagcacaug g                                               21

<210> 353
<211> 21

<212> RNA
<213> Homo sapiens

<220> 353: Antisense oligonucleotide targeting SEQ ID NO: in Region 2+3 of Homo sapiens Numb exon 9 – 21 nt long 
<400> 353
gagcaguaug ggcuggcuua g                                               21

<210> 354
<211> 21

<212> RNA
<213> Homo sapiens

<220> 354: Region of Homo sapiens Numb exon 9 targeted by SEQ ID NO:353
<400> 354
cuaagccagc ccauacugcu c                                               21

<210> 355
<211> 21

<212> RNA
<213> Homo sapiens

<220> 355: Antisense oligonucleotide targeting a in Region 2+3 of Homo sapiens Numb exon 9 – 21 nt long 
<400> 355
gcuagagcagu augggcugg c                                               21

<210> 356
<211> 21

<212> RNA
<213> Homo sapiens

<220> 356: Region of Homo sapiens Numb exon 9 targeted by SEQ ID NO:355
<400> 356
gccagcccau acugcucuag c                                               21


<210> 357
<211> 21

<212> RNA
<213> Artificial Sequence

<220> 357: Random oligonucleotide – 21 nt long
<400> 357
ugauucgugc ggcgcguaua u                                               21
