                         SEQUENCE LISTING

<110>  Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer
        Gesundheit und Umwelt
 
<120>  TRAF 6 inhibitors

<130>  HEL16136PCT

<150>  EP18163317
<151>  2018-03-22

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  EMSA oligonucleotide

<400>  1
gatccagggc tggggattcc ccatctccac agg                                    33


<210>  2
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  EMSA Oligonucleotide

<400>  2
gatccctgtg gagatgggga atccccagcc ctg                                    33


<210>  3
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  ESMA oligonucleotide

<400>  3
gatctgtcga atgcaaatca ctagaa                                            26


<210>  4
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  EMSA oligonucleotide

<400>  4
gatcttctag tgatttgcat tcgaca                                            26


<210>  5
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Mouse A20 for

<400>  5
gctcaactgg tgtcgtgaag                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Mouse A20 rev

<400>  6
atgaggcagt ttccatcacc                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Mouse beta-Actin for

<400>  7
cctctatgcc aacacagtgc                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Mouse beta-Actin rev

<400>  8
gtactcctgc ttgctgatcc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Mouse ICAM-1 for

<400>  9
cgctcagaag aaccaccttc                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Mouse ICAM-1 rev

<400>  10
ggagacgcag aggaccttaa c                                                 21


<210>  11
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Mouse IL-1beta for

<400>  11
tcagcacctc acaagcagag                                                   20


<210>  12
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Mouse IL-1beta rev

<400>  12
gcccatactt taggaagaca cg                                                22


<210>  13
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Mouse IL-2 for

<400>  13
gagtgccaat tcgatgatga g                                                 21


<210>  14
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Mouse IL-2 rev

<400>  14
agggcttgtt gagatgatgc                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Mouse VCAM for

<400>  15
cccctcattc cttaccaccc                                                   20


<210>  16
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Mouse VCAM rev

<400>  16
agttggggat tcggttgttc t                                                 21


<210>  17
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Human IL-2 for

<400>  17
cacagctaca actggagcat ttac                                              24


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Human IL-2 rev

<400>  18
tgctgattaa gtccctgggt c                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Human TNFalpha for

<400>  19
cccagggacc tctctctaat c                                                 21


<210>  20
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Human TNFalpha rev

<400>  20
gctacaggct tgtcactcgg                                                   20


<210>  21
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Human RNA Polymerase II for

<400>  21
gcaccacgtc caatgaca                                                     18


<210>  22
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Human RNA Polymerase II rev

<400>  22
gtgcggctgc ttccataa                                                     18


<210>  23
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  TRAF6-His-protein

<400>  23

Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu Glu 
1               5                   10                  15      


Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala Val 
            20                  25                  30          


Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys Ser 
        35                  40                  45              


Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu Leu 
    50                  55                  60                  


Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu Ser 
65                  70                  75                  80  


Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu Leu 
                85                  90                  95      


Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Gly Ala 
            100                 105                 110         


His His His His His His 
        115             


<210>  24
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  C70A mutant according to Figure 22

<400>  24

Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu Glu 
1               5                   10                  15      


Ser Lys Tyr Glu Ala Pro Ile Cys Leu Met Ala Leu Arg Glu Ala Val 
            20                  25                  30          


Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys Ser 
        35                  40                  45              


Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu Leu 
    50                  55                  60                  


Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu Ser 
65                  70                  75                  80  


Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu Leu 
                85                  90                  95      


Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Gly Ala 
            100                 105                 110         


His His His His His His 
        115             


<210>  25
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Leu Pro Arg Arg Ile Ile Lys Glu Thr Gln Arg Leu Leu Ala Glu 
1               5                   10                  15      


Pro Val Pro Gly Ile Lys Ala Glu Pro Asp Glu Ser Asn Ala Arg Tyr 
            20                  25                  30          


Phe His Val Val Ile Ala Gly Pro Gln Asp Ser Pro Phe Glu Gly Gly 
        35                  40                  45              


Thr Phe Lys Leu Glu Leu Phe Leu Pro Glu Glu Tyr Pro Met Ala Ala 
    50                  55                  60                  


Pro Lys Val Arg Phe Met Thr Lys Ile Tyr His Pro Asn Val Asp Lys 
65                  70                  75                  80  


Leu Gly Arg Ile Cys Leu Asp Ile Leu Lys Asp Lys Trp Ser Pro Ala 
                85                  90                  95      


Leu Gln Ile Arg Thr Val Leu Leu Ser Ile Gln Ala Leu Leu Ser Ala 
            100                 105                 110         


Pro Asn Pro Asp Asp Pro Leu Ala Asn Asp Val Ala Glu Gln Trp Lys 
        115                 120                 125             


Thr Asn Glu Ala Gln Ala Ile Glu Thr Ala Arg Ala Trp Thr Arg Leu 
    130                 135                 140                 


Tyr Ala Met Asn Asn Ile 
145                 150 


<210>  26
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser Pro Gly 
1               5                   10                  15      


Glu Val Gln Ala Ser Tyr Leu Lys Ser Gln Ser Lys Leu Ser Asp Glu 
            20                  25                  30          


Gly Arg Leu Glu Pro Arg Lys Phe His Cys Lys Gly Val Lys Val Pro 
        35                  40                  45              


Arg Asn Phe Arg Leu Leu Glu Glu Leu Glu Glu Gly Gln Lys Gly Val 
    50                  55                  60                  


Gly Asp Gly Thr Val Ser Trp Gly Leu Glu Asp Asp Glu Asp Met Thr 
65                  70                  75                  80  


Leu Thr Arg Trp Thr Gly Met Ile Ile Gly Pro Pro Arg Thr Ile Tyr 
                85                  90                  95      


Glu Asn Arg Ile Tyr Ser Leu Lys Ile Glu Cys Gly Pro Lys Tyr Pro 
            100                 105                 110         


Glu Ala Pro Pro Phe Val Arg Phe Val Thr Lys Ile Asn Met Asn Gly 
        115                 120                 125             


Val Asn Ser Ser Asn Gly Val Val Asp Pro Arg Ala Ile Ser Val Leu 
    130                 135                 140                 


Ala Lys Trp Gln Asn Ser Tyr Ser Ile Lys Val Val Leu Gln Glu Leu 
145                 150                 155                 160 


Arg Arg Leu Met Met Ser Lys Glu Asn Met Lys Leu Pro Gln Pro Pro 
                165                 170                 175     


Glu Gly Gln Cys Tyr Ser Asn 
            180             


<210>  27
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Gly Ser Pro Glu Phe Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys 
225                 230                 235                 240 


Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys 
                245                 250                 255     


Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu 
            260                 265                 270         


Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr 
        275                 280                 285             


Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly 
    290                 295                 300                 


Gly 
305 


<210>  28
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu Glu 
1               5                   10                  15      


Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala Val 
            20                  25                  30          


Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys Ser 
        35                  40                  45              


Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu Leu 
    50                  55                  60                  


Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu Ser 
65                  70                  75                  80  


Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu Leu 
                85                  90                  95      


Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Asp His 
            100                 105                 110         


Gly Leu Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        115                 120                 


<210>  29
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Ubc13 binding mutant (TRAF6 D57K, sequence D57K mutant)

<400>  29

Met Glu Glu Ile Gln Gly Tyr Lys Val Glu Phe Asp Pro Pro Leu Glu 
1               5                   10                  15      


Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala Val 
            20                  25                  30          


Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys Ser 
        35                  40                  45              


Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu Leu 
    50                  55                  60                  


Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu Ser 
65                  70                  75                  80  


Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu Leu 
                85                  90                  95      


Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Asp His 
            100                 105                 110         


Gly Leu Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        115                 120                 


<210>  30
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Ser Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro 
1               5                   10                  15      


Leu Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu 
            20                  25                  30          


Ala Val Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile 
        35                  40                  45              


Lys Ser Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile 
    50                  55                  60                  


Leu Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile 
65                  70                  75                  80  


Leu Ser Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met 
                85                  90                  95      


Glu Leu Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu 
            100                 105                 110         


<210>  31
<211>  174
<212>  PRT
<213>  Artificial

<220>
<223>  human Ubc13 + His Tag

<400>  31

Gly Ser Pro Glu Phe Ala Gly Leu Pro Arg Arg Ile Ile Lys Glu Thr 
1               5                   10                  15      


Gln Arg Leu Leu Ala Glu Pro Val Pro Gly Ile Lys Ala Glu Pro Asp 
            20                  25                  30          


Glu Ser Asn Ala Arg Tyr Phe His Val Val Ile Ala Gly Pro Gln Asp 
        35                  40                  45              


Ser Pro Phe Glu Gly Gly Thr Phe Lys Leu Glu Leu Phe Leu Pro Glu 
    50                  55                  60                  


Glu Tyr Pro Met Ala Ala Pro Lys Val Arg Phe Met Thr Lys Ile Tyr 
65                  70                  75                  80  


His Pro Asn Val Asp Lys Leu Gly Arg Ile Cys Leu Asp Ile Leu Lys 
                85                  90                  95      


Asp Lys Trp Ser Pro Ala Leu Gln Ile Arg Thr Val Leu Leu Ser Ile 
            100                 105                 110         


Gln Ala Leu Leu Ser Ala Pro Asn Pro Asp Asp Pro Leu Ala Asn Asp 
        115                 120                 125             


Val Ala Glu Gln Trp Lys Thr Asn Glu Ala Gln Ala Ile Glu Thr Ala 
    130                 135                 140                 


Arg Ala Trp Thr Arg Leu Tyr Ala Met Asn Asn Ile Gly Ala Asp Tyr 
145                 150                 155                 160 


Lys Asp Asp Asp Asp Lys Gly Ala His His His His His His 
                165                 170                 


<210>  32
<211>  496
<212>  PRT
<213>  Artificial

<220>
<223>  GST-OTUB1

<400>  32

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Gly Ser Ala Ala Glu Glu Pro Gln Gln Gln Lys Gln Glu Pro Leu Gly 
225                 230                 235                 240 


Ser Asp Ser Glu Gly Val Asn Cys Leu Ala Tyr Asp Glu Ala Ile Met 
                245                 250                 255     


Ala Gln Gln Asp Arg Ile Gln Gln Glu Ile Ala Val Gln Asn Pro Leu 
            260                 265                 270         


Val Ser Glu Arg Leu Glu Leu Ser Val Leu Tyr Lys Glu Tyr Ala Glu 
        275                 280                 285             


Asp Asp Asn Ile Tyr Gln Gln Lys Ile Lys Asp Leu His Lys Lys Tyr 
    290                 295                 300                 


Ser Tyr Ile Arg Lys Thr Arg Pro Asp Gly Asn Cys Phe Tyr Arg Ala 
305                 310                 315                 320 


Phe Gly Phe Ser His Leu Glu Ala Leu Leu Asp Asp Ser Lys Glu Leu 
                325                 330                 335     


Gln Arg Phe Lys Ala Val Ser Ala Lys Ser Lys Glu Asp Leu Val Ser 
            340                 345                 350         


Gln Gly Phe Thr Glu Phe Thr Ile Glu Asp Phe His Asn Thr Phe Met 
        355                 360                 365             


Asp Leu Ile Glu Gln Val Glu Lys Gln Thr Ser Val Ala Asp Leu Leu 
    370                 375                 380                 


Ala Ser Phe Asn Asp Gln Ser Thr Ser Asp Tyr Leu Val Val Tyr Leu 
385                 390                 395                 400 


Arg Leu Leu Thr Ser Gly Tyr Leu Gln Arg Glu Ser Lys Phe Phe Glu 
                405                 410                 415     


His Phe Ile Glu Gly Gly Arg Thr Val Lys Glu Phe Cys Gln Gln Glu 
            420                 425                 430         


Val Glu Pro Met Cys Lys Glu Ser Asp His Ile His Ile Ile Ala Leu 
        435                 440                 445             


Ala Gln Ala Leu Ser Val Ser Ile Gln Val Glu Tyr Met Asp Arg Gly 
    450                 455                 460                 


Glu Gly Gly Thr Thr Asn Pro His Ile Phe Pro Glu Gly Ser Glu Pro 
465                 470                 475                 480 


Lys Val Tyr Leu Leu Tyr Arg Pro Gly His Tyr Asp Ile Leu Tyr Lys 
                485                 490                 495     


<210>  33
<211>  380
<212>  PRT
<213>  Artificial

<220>
<223>  GST-Ubc13

<400>  33

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Gly Ser Pro Glu Phe Ala Gly Leu Pro Arg Arg Ile Ile Lys Glu Thr 
225                 230                 235                 240 


Gln Arg Leu Leu Ala Glu Pro Val Pro Gly Ile Lys Ala Glu Pro Asp 
                245                 250                 255     


Glu Ser Asn Ala Arg Tyr Phe His Val Val Ile Ala Gly Pro Gln Asp 
            260                 265                 270         


Ser Pro Phe Glu Gly Gly Thr Phe Lys Leu Glu Leu Phe Leu Pro Glu 
        275                 280                 285             


Glu Tyr Pro Met Ala Ala Pro Lys Val Arg Phe Met Thr Lys Ile Tyr 
    290                 295                 300                 


His Pro Asn Val Asp Lys Leu Gly Arg Ile Cys Leu Asp Ile Leu Lys 
305                 310                 315                 320 


Asp Lys Trp Ser Pro Ala Leu Gln Ile Arg Thr Val Leu Leu Ser Ile 
                325                 330                 335     


Gln Ala Leu Leu Ser Ala Pro Asn Pro Asp Asp Pro Leu Ala Asn Asp 
            340                 345                 350         


Val Ala Glu Gln Trp Lys Thr Asn Glu Ala Gln Ala Ile Glu Thr Ala 
        355                 360                 365             


Arg Ala Trp Thr Arg Leu Tyr Ala Met Asn Asn Ile 
    370                 375                 380 


<210>  34
<211>  181
<212>  PRT
<213>  Artificial

<220>
<223>  His-tagged Uev1a

<400>  34

Ser Pro Gly Glu Val Gln Ala Ser Tyr Leu Lys Ser Gln Ser Lys Leu 
1               5                   10                  15      


Ser Asp Glu Gly Arg Leu Glu Pro Arg Lys Phe His Cys Lys Gly Val 
            20                  25                  30          


Lys Val Pro Arg Asn Phe Arg Leu Leu Glu Glu Leu Glu Glu Gly Gln 
        35                  40                  45              


Lys Gly Val Gly Asp Gly Thr Val Ser Trp Gly Leu Glu Asp Asp Glu 
    50                  55                  60                  


Asp Met Thr Leu Thr Arg Trp Thr Gly Met Ile Ile Gly Pro Pro Arg 
65                  70                  75                  80  


Thr Ile Tyr Glu Asn Arg Ile Tyr Ser Leu Lys Ile Glu Cys Gly Pro 
                85                  90                  95      


Lys Tyr Pro Glu Ala Pro Pro Phe Val Arg Phe Val Thr Lys Ile Asn 
            100                 105                 110         


Met Asn Gly Val Asn Ser Ser Asn Gly Val Val Asp Pro Arg Ala Ile 
        115                 120                 125             


Ser Val Leu Ala Lys Trp Gln Asn Ser Tyr Ser Ile Lys Val Val Leu 
    130                 135                 140                 


Gln Glu Leu Arg Arg Leu Met Met Ser Lys Glu Asn Met Lys Leu Pro 
145                 150                 155                 160 


Gln Pro Pro Glu Gly Gln Cys Tyr Ser Asn Ala Ala Ala Leu Glu His 
                165                 170                 175     


His His His His His 
            180     


