                         SEQUENCE LISTING

<110>  MERCK SHARP & DOHME CORP.
       ALTMAN, MICHAEL D.
       CHILDERS, Matthew L.
       JEWELL, JAMES P.
       LESBURG, CHARLES A.
       SIU, TONY
 
<120>  OXO-TETRAHYDRO-ISOQUINOLINE CARBOXYLIC ACIDS AS STING INHIBITORS

<130>  24575

<150>  62/645,309 
<151>  2018-03-20

<150>  62/730,588 
<151>  2018-09-13

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-Length HAQ STING 
       [STING(1-379)R71H,G230A,H232R,R293Q-GG-AviTag-GS-HRV3C-HIS8]Amino
       Acid Sequence

<400>  1

Met Pro His Ser Ser Leu His Pro Ser Ile Pro Cys Pro Arg Gly His 
1               5                   10                  15      


Gly Ala Gln Lys Ala Ala Leu Val Leu Leu Ser Ala Cys Leu Val Thr 
            20                  25                  30          


Leu Trp Gly Leu Gly Glu Pro Pro Glu His Thr Leu Arg Tyr Leu Val 
        35                  40                  45              


Leu His Leu Ala Ser Leu Gln Leu Gly Leu Leu Leu Asn Gly Val Cys 
    50                  55                  60                  


Ser Leu Ala Glu Glu Leu His His Ile His Ser Arg Tyr Arg Gly Ser 
65                  70                  75                  80  


Tyr Trp Arg Thr Val Arg Ala Cys Leu Gly Cys Pro Leu Arg Arg Gly 
                85                  90                  95      


Ala Leu Leu Leu Leu Ser Ile Tyr Phe Tyr Tyr Ser Leu Pro Asn Ala 
            100                 105                 110         


Val Gly Pro Pro Phe Thr Trp Met Leu Ala Leu Leu Gly Leu Ser Gln 
        115                 120                 125             


Ala Leu Asn Ile Leu Leu Gly Leu Lys Gly Leu Ala Pro Ala Glu Ile 
    130                 135                 140                 


Ser Ala Val Cys Glu Lys Gly Asn Phe Asn Val Ala His Gly Leu Ala 
145                 150                 155                 160 


Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Glu Leu Gln 
                165                 170                 175     


Ala Arg Ile Arg Thr Tyr Asn Gln His Tyr Asn Asn Leu Leu Arg Gly 
            180                 185                 190         


Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro Leu Asp Cys Gly Val 
        195                 200                 205             


Pro Asp Asn Leu Ser Met Ala Asp Pro Asn Ile Arg Phe Leu Asp Lys 
    210                 215                 220                 


Leu Pro Gln Gln Thr Ala Asp Arg Ala Gly Ile Lys Asp Arg Val Tyr 
225                 230                 235                 240 


Ser Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly Gln Arg Ala Gly Thr 
                245                 250                 255     


Cys Val Leu Glu Tyr Ala Thr Pro Leu Gln Thr Leu Phe Ala Met Ser 
            260                 265                 270         


Gln Tyr Ser Gln Ala Gly Phe Ser Arg Glu Asp Arg Leu Glu Gln Ala 
        275                 280                 285             


Lys Leu Phe Cys Gln Thr Leu Glu Asp Ile Leu Ala Asp Ala Pro Glu 
    290                 295                 300                 


Ser Gln Asn Asn Cys Arg Leu Ile Ala Tyr Gln Glu Pro Ala Asp Asp 
305                 310                 315                 320 


Ser Ser Phe Ser Leu Ser Gln Glu Val Leu Arg His Leu Arg Gln Glu 
                325                 330                 335     


Glu Lys Glu Glu Val Thr Val Gly Ser Leu Lys Thr Ser Ala Val Pro 
            340                 345                 350         


Ser Thr Ser Thr Met Ser Gln Glu Pro Glu Leu Leu Ile Ser Gly Met 
        355                 360                 365             


Glu Lys Pro Leu Pro Leu Arg Thr Asp Phe Ser Gly Gly Gly Leu Asn 
    370                 375                 380                 


Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Ser Leu Glu 
385                 390                 395                 400 


Val Leu Phe Gln Gly Pro His His His His His His His His 
                405                 410                 


<210>  2
<211>  6482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full-length HAQ 
       [STING(1-379)R71H,G230A,H232R,R293Q-GG-AviTag-GS-HRV3C-HIS8/pBAC1
       ] Plasmid DNA Sequence

<400>  2
ggaacggctc cgcccactat taatgaaatt aaaaattcca attttaaaaa acgcagcaag       60

agaaacattt gtatgaaaga atgcgtagaa ggaaagaaaa atgtcgtcga catgctgaac      120

aacaagatta atatgcctcc gtgtataaaa aaaatattga acgatttgaa agaaaacaat      180

gtaccgcgcg gcggtatgta caggaagagg tttatactaa actgttacat tgcaaacgtg      240

gtttcgtgtg ccaagtgtga aaaccgatgt ttaatcaagg ctctgacgca tttctacaac      300

cacgactcca agtgtgtggg tgaagtcatg catcttttaa tcaaatccca agatgtgtat      360

aaaccaccaa actgccaaaa aatgaaaact gtcgacaagc tctgtccgtt tgctggcaac      420

tgcaagggtc tcaatcctat ttgtaattat tgaataataa aacaattata aatgctaaat      480

ttgtttttta ttaacgatac aaaccaaacg caacaagaac atttgtagta ttatctataa      540

ttgaaaacgc gtagttataa tcgctgaggt aatatttaaa atcattttca aatgattcac      600

agttaatttg cgacaatata attttatttt cacataaact agacgccttg tcgtcttctt      660

cttcgtattc cttctctttt tcatttttct cttcataaaa attaacatag ttattatcgt      720

atccatatat gtatctatcg tatagagtaa attttttgtt gtcataaata tatatgtctt      780

ttttaatggg gtgtatagta ccgctgcgca tagtttttct gtaatttaca acagtgctat      840

tttctggtag ttcttcggag tgtgttgctt taattattaa atttatataa tcaatgaatt      900

tgggatcgtc ggttttgtac aatatgttgc cggcatagta cgcagcttct tctagttcaa      960

ttacaccatt ttttagcagc accggattaa cataactttc caaaatgttg tacgaaccgt     1020

taaacaaaaa cagttcacct cccttttcta tactattgtc tgcgagcagt tgtttgttgt     1080

taaaaataac agccattgta atgagacgca caaactaata tcacaaactg gaaatgtcta     1140

tcaatatata gttgctgatc agatctgatc atggagataa ttaaaatgat aaccatctcg     1200

caaataaata agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata     1260

taggatccat gccccactcc agcctgcatc catccatccc gtgtcccagg ggtcacgggg     1320

cccagaaggc agccttggtt ctgctgagtg cctgcctggt gaccctttgg gggctaggag     1380

agccaccaga gcacactctc cggtacctgg tgctccacct agcctccctg cagctgggac     1440

tgctgttaaa cggggtctgc agcctggctg aggagctgca ccacatccac tccaggtacc     1500

ggggcagcta ctggaggact gtgcgggcct gcctgggctg ccccctccgc cgtggggccc     1560

tgttgctgct gtccatctat ttctactact ccctcccaaa tgcggtcggc ccgcccttca     1620

cttggatgct tgccctcctg ggcctctcgc aggcactgaa catcctcctg ggcctcaagg     1680

gcctggcccc agctgagatc tctgcagtgt gtgaaaaagg gaatttcaac gtggcccatg     1740

ggctggcatg gtcatattac atcggatatc tgcggctgat cctgccagag ctccaggccc     1800

ggattcgaac ttacaatcag cattacaaca acctgctacg gggtgcagtg agccagcggc     1860

tgtatattct cctcccattg gactgtgggg tgcctgataa cctgagtatg gctgacccca     1920

acattcgctt cctggataaa ctgccccagc agaccgctga ccgtgctggc atcaaggatc     1980

gggtttacag caacagcatc tatgagcttc tggagaacgg gcagcgggcg ggcacctgtg     2040

tcctggagta cgccaccccc ttgcagactt tgtttgccat gtcacaatac agtcaagctg     2100

gctttagccg ggaggatagg cttgagcagg ccaaactctt ctgccagaca cttgaggaca     2160

tcctggcaga tgcccctgag tctcagaaca actgccgcct cattgcctac caggaacctg     2220

cagatgacag cagcttctcg ctgtcccagg aggttctccg gcacctgcgg caggaggaaa     2280

aggaagaggt tactgtgggc agcttgaaga cctcagcggt gcccagtacc tccacgatgt     2340

cccaagagcc tgagctcctc atcagtggaa tggaaaagcc cctccctctc cgcacggatt     2400

tctctggcgg tggcctgaac gacatcttcg aagcccagaa aatcgaatgg catgaaggca     2460

gcctggaagt gctgttccag ggcccacacc accatcatca ccatcaccat taatgagcgg     2520

ccgcactcga gcaccaccac caccaccact aacctaggta gctgagcgca tgcaagctga     2580

tccgggttat tagtacattt attaagcgct agattctgtg cgttgttgat ttacagacaa     2640

ttgttgtacg tattttaata attcattaaa tttataatct ttagggtggt atgttagagc     2700

gaaaatcaaa tgattttcag cgtctttata tctgaattta aatattaaat cctcaataga     2760

tttgtaaaat aggtttcgat tagtttcaaa caagggttgt ttttccgaac cgatggctgg     2820

actatctaat ggattttcgc tcaacgccac aaaacttgcc aaatcttgta gcagcaatct     2880

agctttgtcg atattcgttt gtgttttgtt ttgtaataaa ggttcgacgt cgttcaaaat     2940

attatgcgct tttgtatttc tttcatcact gtcgttagtg tacaattgac tcgacgtaaa     3000

cacgttaaat agagcttgga catatttaac atcgggcgtg ttagctttat taggccgatt     3060

atcgtcgtcg tcccaaccct cgtcgttaga agttgcttcc gaagacgatt ttgccatagc     3120

cacacgacgc ctattaattg tgtcggctaa cacgtccgcg atcaaatttg tagttgagct     3180

ttttggaatt atttctgatt gcgggcgttt ttgggcgggt ttcaatctaa ctgtgcccga     3240

ttttaattca gacaacacgt tagaaagcga tggtgcaggc ggtggtaaca tttcagacgg     3300

caaatctact aatggcggcg gtggtggagc tgatgataaa tctaccatcg gtggaggcgc     3360

aggcggggct ggcggcggag gcggaggcgg aggtggtggc ggtgatgcag acggcggttt     3420

aggctcaaat gtctctttag gcaacacagt cggcacctca actattgtac tggtttcggg     3480

cgccgttttt ggtttgaccg gtctgagacg agtgcgattt ttttcgtttc taatagcttc     3540

caacaattgt tgtctgtcgt ctaaaggtgc agcgggttga ggttccgtcg gcattggtgg     3600

agcgggcggc aattcagaca tcgatggtgg tggtggtggt ggaggcgctg gaatgttagg     3660

cacgggagaa ggtggtggcg gcggtgccgc cggtataatt tgttctggtt tagtttgttc     3720

gcgcacgatt gtgggcaccg gcgcaggcgc cgctggctgc acaacggaag gtcgtctgct     3780

tcgaggcagc gcttggggtg gtggcaattc aatattataa ttggaataca aatcgtaaaa     3840

atctgctata agcattgtaa tttcgctatc gtttaccgtg ccgatattta acaaccgctc     3900

aatgtaagca attgtattgt aaagagattg tctcaagctc ggatcgatcc cgcacgccga     3960

taacaagcct tttcattttt actacagcat tgtagtggcg agacacttcg ctgtcgtcga     4020

ggtttaaacg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg     4080

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga     4140

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     4200

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     4260

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     4320

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     4380

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     4440

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     4500

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     4560

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     4620

tggcctaact acggctacac tagaaggaca gtatttggta tctgcgctct gctgaagcca     4680

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     4740

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     4800

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     4860

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     4920

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     4980

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcccc     5040

gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc tgcaatgata     5100

ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc agccggaagg     5160

gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat taattgttgc     5220

cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt tgccattgct     5280

acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc cggttcccaa     5340

cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag ctccttcggt     5400

cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt tatggcagca     5460

ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac tggtgagtac     5520

tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg cccggcgtca     5580

atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat tggaaaacgt     5640

tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc gatgtaaccc     5700

actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc tgggtgagca     5760

aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa atgttgaata     5820

ctcatactct tcctttttca atattattga agcatttatc agggttattg tctcatgagc     5880

ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc     5940

cgaaaagtgc cacctgacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     6000

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     6060

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     6120

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     6180

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     6240

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     6300

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     6360

atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat ttcccattcg     6420

ccattcaggc tgcgcaactg ttgggaaggg cgatcggtgc gggcctcttc gctattacgc     6480

ca                                                                    6482


