                         SEQUENCE LISTING

<110>  National Health Research Institutes
 
<120>  Dual-Function Antibodies Targeting VEGFR2 and VEGFR3

<130>  218384-0016PCT

<150>  US 62/645,437
<151>  2018-03-20

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C7-1 VH

<400>  1

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Phe Ile Asn Trp Val Ile Gln Arg His Gly Lys Ser Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Gly Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Ile Ala His 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Ala Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Asn Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  2
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C7-1 VL

<400>  2

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Ile Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  3
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C9-11 VH

<400>  3

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Leu Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  4
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C9-11 VL

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Asn Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Tyr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Ser 
                85                  90                  95      


Asp His Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C7-1 VH CDR-1; Kabat

<400>  5

Asp Tyr Phe Ile Asn 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C7-1 VH CDR-2; Kabat

<400>  6

Arg Ile Asn Pro Tyr Asn Gly Gly Ser Phe Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C7-1 VH CDR-3

<400>  7

Ser Gly Gly Asn Gly Tyr Asp Tyr 
1               5               


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C7-1 VH CDR-1; Chothia

<400>  8

Gly Tyr Ser Phe Thr Asp Tyr 
1               5           


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C7-1 VH CDR-2; Chothia

<400>  9

Asn Pro Tyr Asn Gly Gly 
1               5       


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C7-1 VL CDR-1

<400>  10

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C7-1 VL CDR-2

<400>  11

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C7-1 VL CDR-3

<400>  12

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C9-11 VH CDR-1; Kabat

<400>  13

Ser Tyr Trp Met His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C9-11 VH CDR-2; Kabat

<400>  14

Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C9-11 VH CDR-3

<400>  15

Leu Tyr Phe Asp Val 
1               5   


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C9-11 VH CDR-1; Chothia

<400>  16

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C9-11 VH CDR-2; Chothia

<400>  17

Asn Pro Ser Asn Gly Arg 
1               5       


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C9-11 VL CDR-1

<400>  18

Lys Ser Ser Gln Asn Leu Leu Asn Ser Gly Asn Gln Lys Tyr Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C9-11 VL CDR-2

<400>  19

Gly Ala Ser Ile Arg Glu Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2C9-11 VL CDR-3

<400>  20

Gln Ser Asp His Ser Tyr Pro Tyr Thr 
1               5                   


