                               SEQUENCE LISTING

<110> RUBIUS THERAPEUTICS, INC.
 
<120> THERAPEUTIC CELL SYSTEMS AND METHODS FOR TREATING HOMOCYSTINURIA

<130> 129267-00820

<140>
<141>

<150> 62/742,272
<151> 2018-10-05

<150> 62/680,467
<151> 2018-06-04

<150> 62/645,786
<151> 2018-03-20

<160> 112    

<170> PatentIn version 3.5

<210> 1
<211> 551
<212> PRT
<213> Homo sapiens

<400> 1
Met Pro Ser Glu Thr Pro Gln Ala Glu Val Gly Pro Thr Gly Cys Pro 
1               5                   10                  15      


His Arg Ser Gly Pro His Ser Ala Lys Gly Ser Leu Glu Lys Gly Ser 
            20                  25                  30          


Pro Glu Asp Lys Glu Ala Lys Glu Pro Leu Trp Ile Arg Pro Asp Ala 
        35                  40                  45              


Pro Ser Arg Cys Thr Trp Gln Leu Gly Arg Pro Ala Ser Glu Ser Pro 
    50                  55                  60                  


His His His Thr Ala Pro Ala Lys Ser Pro Lys Ile Leu Pro Asp Ile 
65                  70                  75                  80  


Leu Lys Lys Ile Gly Asp Thr Pro Met Val Arg Ile Asn Lys Ile Gly 
                85                  90                  95      


Lys Lys Phe Gly Leu Lys Cys Glu Leu Leu Ala Lys Cys Glu Phe Phe 
            100                 105                 110         


Asn Ala Gly Gly Ser Val Lys Asp Arg Ile Ser Leu Arg Met Ile Glu 
        115                 120                 125             


Asp Ala Glu Arg Asp Gly Thr Leu Lys Pro Gly Asp Thr Ile Ile Glu 
    130                 135                 140                 


Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Ala Ala Val 
145                 150                 155                 160 


Arg Gly Tyr Arg Cys Ile Ile Val Met Pro Glu Lys Met Ser Ser Glu 
                165                 170                 175     


Lys Val Asp Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr Pro 
            180                 185                 190         


Thr Asn Ala Arg Phe Asp Ser Pro Glu Ser His Val Gly Val Ala Trp 
        195                 200                 205             


Arg Leu Lys Asn Glu Ile Pro Asn Ser His Ile Leu Asp Gln Tyr Arg 
    210                 215                 220                 


Asn Ala Ser Asn Pro Leu Ala His Tyr Asp Thr Thr Ala Asp Glu Ile 
225                 230                 235                 240 


Leu Gln Gln Cys Asp Gly Lys Leu Asp Met Leu Val Ala Ser Val Gly 
                245                 250                 255     


Thr Gly Gly Thr Ile Thr Gly Ile Ala Arg Lys Leu Lys Glu Lys Cys 
            260                 265                 270         


Pro Gly Cys Arg Ile Ile Gly Val Asp Pro Glu Gly Ser Ile Leu Ala 
        275                 280                 285             


Glu Pro Glu Glu Leu Asn Gln Thr Glu Gln Thr Thr Tyr Glu Val Glu 
    290                 295                 300                 


Gly Ile Gly Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Thr Val Val 
305                 310                 315                 320 


Asp Lys Trp Phe Lys Ser Asn Asp Glu Glu Ala Phe Thr Phe Ala Arg 
                325                 330                 335     


Met Leu Ile Ala Gln Glu Gly Leu Leu Cys Gly Gly Ser Ala Gly Ser 
            340                 345                 350         


Thr Val Ala Val Ala Val Lys Ala Ala Gln Glu Leu Gln Glu Gly Gln 
        355                 360                 365             


Arg Cys Val Val Ile Leu Pro Asp Ser Val Arg Asn Tyr Met Thr Lys 
    370                 375                 380                 


Phe Leu Ser Asp Arg Trp Met Leu Gln Lys Gly Phe Leu Lys Glu Glu 
385                 390                 395                 400 


Asp Leu Thr Glu Lys Lys Pro Trp Trp Trp His Leu Arg Val Gln Glu 
                405                 410                 415     


Leu Gly Leu Ser Ala Pro Leu Thr Val Leu Pro Thr Ile Thr Cys Gly 
            420                 425                 430         


His Thr Ile Glu Ile Leu Arg Glu Lys Gly Phe Asp Gln Ala Pro Val 
        435                 440                 445             


Val Asp Glu Ala Gly Val Ile Leu Gly Met Val Thr Leu Gly Asn Met 
    450                 455                 460                 


Leu Ser Ser Leu Leu Ala Gly Lys Val Gln Pro Ser Asp Gln Val Gly 
465                 470                 475                 480 


Lys Val Ile Tyr Lys Gln Phe Lys Gln Ile Arg Leu Thr Asp Thr Leu 
                485                 490                 495     


Gly Arg Leu Ser His Ile Leu Glu Met Asp His Phe Ala Leu Val Val 
            500                 505                 510         


His Glu Gln Ile Gln Tyr His Ser Thr Gly Lys Ser Ser Gln Arg Gln 
        515                 520                 525             


Met Val Phe Gly Val Val Thr Ala Ile Asp Leu Leu Asn Phe Val Ala 
    530                 535                 540                 


Ala Gln Glu Arg Asp Gln Lys 
545                 550     


<210> 2
<211> 507
<212> PRT
<213> Saccharomyces cerevisiae

<400> 2
Met Thr Lys Ser Glu Gln Gln Ala Asp Ser Arg His Asn Val Ile Asp 
1               5                   10                  15      


Leu Val Gly Asn Thr Pro Leu Ile Ala Leu Lys Lys Leu Pro Lys Ala 
            20                  25                  30          


Leu Gly Ile Lys Pro Gln Ile Tyr Ala Lys Leu Glu Leu Tyr Asn Pro 
        35                  40                  45              


Gly Gly Ser Ile Lys Asp Arg Ile Ala Lys Ser Met Val Glu Glu Ala 
    50                  55                  60                  


Glu Ala Ser Gly Arg Ile His Pro Ser Arg Ser Thr Leu Ile Glu Pro 
65                  70                  75                  80  


Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ile Gly Ala Ile Lys 
                85                  90                  95      


Gly Tyr Arg Thr Ile Ile Thr Leu Pro Glu Lys Met Ser Asn Glu Lys 
            100                 105                 110         


Val Ser Val Leu Lys Ala Leu Gly Ala Glu Ile Ile Arg Thr Pro Thr 
        115                 120                 125             


Ala Ala Ala Trp Asp Ser Pro Glu Ser His Ile Gly Val Ala Lys Lys 
    130                 135                 140                 


Leu Glu Lys Glu Ile Pro Gly Ala Val Ile Leu Asp Gln Tyr Asn Asn 
145                 150                 155                 160 


Met Met Asn Pro Glu Ala His Tyr Phe Gly Thr Gly Arg Glu Ile Gln 
                165                 170                 175     


Arg Gln Leu Glu Asp Leu Asn Leu Phe Asp Asn Leu Arg Ala Val Val 
            180                 185                 190         


Ala Gly Ala Gly Thr Gly Gly Thr Ile Ser Gly Ile Ser Lys Tyr Leu 
        195                 200                 205             


Lys Glu Gln Asn Asp Lys Ile Gln Ile Val Gly Ala Asp Pro Phe Gly 
    210                 215                 220                 


Ser Ile Leu Ala Gln Pro Glu Asn Leu Asn Lys Thr Asp Ile Thr Asp 
225                 230                 235                 240 


Tyr Lys Val Glu Gly Ile Gly Tyr Asp Phe Val Pro Gln Val Leu Asp 
                245                 250                 255     


Arg Lys Leu Ile Asp Val Trp Tyr Lys Thr Asp Asp Lys Pro Ser Phe 
            260                 265                 270         


Lys Tyr Ala Arg Gln Leu Ile Ser Asn Glu Gly Val Leu Val Gly Gly 
        275                 280                 285             


Ser Ser Gly Ser Ala Phe Thr Ala Val Val Lys Tyr Cys Glu Asp His 
    290                 295                 300                 


Pro Glu Leu Thr Glu Asp Asp Val Ile Val Ala Ile Phe Pro Asp Ser 
305                 310                 315                 320 


Ile Arg Ser Tyr Leu Thr Lys Phe Val Asp Asp Glu Trp Leu Lys Lys 
                325                 330                 335     


Asn Asn Leu Trp Asp Asp Asp Val Leu Ala Arg Phe Asp Ser Ser Lys 
            340                 345                 350         


Leu Glu Ala Ser Thr Thr Lys Tyr Ala Asp Val Phe Gly Asn Ala Thr 
        355                 360                 365             


Val Lys Asp Leu His Leu Lys Pro Val Val Ser Val Lys Glu Thr Ala 
    370                 375                 380                 


Lys Val Thr Asp Val Ile Lys Ile Leu Lys Asp Asn Gly Phe Asp Gln 
385                 390                 395                 400 


Leu Pro Val Leu Thr Glu Asp Gly Lys Leu Ser Gly Leu Val Thr Leu 
                405                 410                 415     


Ser Glu Leu Leu Arg Lys Leu Ser Ile Asn Asn Ser Asn Asn Asp Asn 
            420                 425                 430         


Thr Ile Lys Gly Lys Tyr Leu Asp Phe Lys Lys Leu Asn Asn Phe Asn 
        435                 440                 445             


Asp Val Ser Ser Tyr Asn Glu Asn Lys Ser Gly Lys Lys Lys Phe Ile 
    450                 455                 460                 


Lys Phe Asp Glu Asn Ser Lys Leu Ser Asp Leu Asn Arg Phe Phe Glu 
465                 470                 475                 480 


Lys Asn Ser Ser Ala Val Ile Thr Asp Gly Leu Lys Pro Ile His Ile 
                485                 490                 495     


Val Thr Lys Met Asp Leu Leu Ser Tyr Leu Ala 
            500                 505         


<210> 3
<211> 561
<212> PRT
<213> Mus musculus

<400> 3
Met Pro Ser Gly Thr Ser Gln Cys Glu Asp Gly Ser Ala Gly Gly Phe 
1               5                   10                  15      


Gln His Leu Asp Met His Ser Glu Lys Arg Gln Leu Glu Lys Gly Pro 
            20                  25                  30          


Ser Gly Asp Lys Asp Arg Val Trp Ile Arg Pro Asp Thr Pro Ser Arg 
        35                  40                  45              


Cys Thr Trp Gln Leu Gly Arg Ala Met Ala Asp Ser Pro His Tyr His 
    50                  55                  60                  


Thr Val Leu Thr Lys Ser Pro Lys Ile Leu Pro Asp Ile Leu Arg Lys 
65                  70                  75                  80  


Ile Gly Asn Thr Pro Met Val Arg Ile Asn Lys Ile Ser Lys Asn Ala 
                85                  90                  95      


Gly Leu Lys Cys Glu Leu Leu Ala Lys Cys Glu Phe Phe Asn Ala Gly 
            100                 105                 110         


Gly Ser Val Lys Asp Arg Ile Ser Leu Arg Met Ile Glu Asp Ala Glu 
        115                 120                 125             


Arg Ala Gly Asn Leu Lys Pro Gly Asp Thr Ile Ile Glu Pro Thr Ser 
    130                 135                 140                 


Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Ala Ala Val Lys Gly Tyr 
145                 150                 155                 160 


Arg Cys Ile Ile Val Met Pro Glu Lys Met Ser Met Glu Lys Val Asp 
                165                 170                 175     


Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr Pro Thr Asn Ala 
            180                 185                 190         


Arg Phe Asp Ser Pro Glu Ser His Val Gly Val Ala Trp Arg Leu Lys 
        195                 200                 205             


Asn Glu Ile Pro Asn Ser His Ile Leu Asp Gln Tyr Arg Asn Ala Ser 
    210                 215                 220                 


Asn Pro Leu Ala His Tyr Asp Asp Thr Ala Glu Glu Ile Leu Gln Gln 
225                 230                 235                 240 


Cys Asp Gly Lys Leu Asp Met Leu Val Ala Ser Ala Gly Thr Gly Gly 
                245                 250                 255     


Thr Ile Thr Gly Ile Ala Arg Lys Leu Lys Glu Lys Cys Pro Gly Cys 
            260                 265                 270         


Lys Ile Ile Gly Val Asp Pro Glu Gly Ser Ile Leu Ala Glu Pro Glu 
        275                 280                 285             


Glu Leu Asn Gln Thr Glu Gln Thr Ala Tyr Glu Val Glu Gly Ile Gly 
    290                 295                 300                 


Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Ala Val Val Asp Lys Trp 
305                 310                 315                 320 


Phe Lys Ser Asn Asp Glu Asp Ser Phe Ala Phe Ala Arg Met Leu Ile 
                325                 330                 335     


Ala Gln Glu Gly Leu Leu Cys Gly Gly Ser Ser Gly Ser Ala Met Ala 
            340                 345                 350         


Val Ala Val Lys Ala Ala Arg Glu Leu Gln Glu Gly Gln Arg Cys Val 
        355                 360                 365             


Val Ile Leu Pro Asp Ser Val Arg Asn Tyr Met Ser Lys Phe Leu Ser 
    370                 375                 380                 


Asp Lys Trp Met Leu Gln Lys Gly Phe Met Lys Glu Glu Leu Ser Val 
385                 390                 395                 400 


Lys Arg Pro Trp Trp Trp Arg Leu Arg Val Gln Glu Leu Ser Leu Ser 
                405                 410                 415     


Ala Pro Leu Thr Val Leu Pro Thr Val Thr Cys Glu Asp Thr Ile Ala 
            420                 425                 430         


Ile Leu Arg Glu Lys Gly Phe Asp Gln Ala Pro Val Val Asn Glu Ser 
        435                 440                 445             


Gly Ala Ile Leu Gly Met Val Thr Leu Gly Asn Met Leu Ser Ser Leu 
    450                 455                 460                 


Leu Ala Gly Lys Val Arg Pro Ser Asp Glu Val Cys Lys Val Leu Tyr 
465                 470                 475                 480 


Lys Gln Phe Lys Pro Ile His Leu Thr Asp Thr Leu Gly Thr Leu Ser 
                485                 490                 495     


His Ile Leu Glu Met Asp His Phe Ala Leu Val Val His Glu Gln Ile 
            500                 505                 510         


Gln Ser Arg Asp Gln Ala Trp Ser Gly Val Val Gly Gly Pro Thr Asp 
        515                 520                 525             


Cys Ser Asn Gly Met Ser Ser Lys Gln Gln Met Val Phe Gly Val Val 
    530                 535                 540                 


Thr Ala Ile Asp Leu Leu Asn Phe Val Ala Ala Arg Glu Gln Thr Gln 
545                 550                 555                 560 


Thr 
    


<210> 4
<211> 551
<212> PRT
<213> Oryctolagus cuniculus

<400> 4
Met Pro Ser Glu Thr Ala Gln Ala Gly Glu Gly Pro Ala Gly Cys Pro 
1               5                   10                  15      


His Leu Ser Gly Ala Gln Gly Ser Asp Arg Ser Leu Asp Gln Arg Pro 
            20                  25                  30          


Pro Gly Asn Lys Asp Ala Pro Glu Arg Val Trp Ile Arg Pro Asp Val 
        35                  40                  45              


Pro Ser Arg Cys Thr Trp Glu Leu Gly Arg Pro Val Ala Asp Ser Pro 
    50                  55                  60                  


His Gln His Ala Ala Leu Ala Lys Ser Pro Lys Ile Leu Pro Asp Ile 
65                  70                  75                  80  


Leu Gln Lys Ile Gly Asp Thr Pro Met Val Arg Ile Asn Lys Ile Gly 
                85                  90                  95      


Lys Asn Phe Gly Leu Lys Cys Glu Leu Leu Ala Lys Cys Glu Phe Phe 
            100                 105                 110         


Asn Ala Gly Gly Ser Val Lys Asp Arg Ile Ser Leu Arg Met Ile Glu 
        115                 120                 125             


Asp Ala Glu Arg Ala Gly Thr Leu Arg Pro Gly Asp Thr Ile Ile Glu 
    130                 135                 140                 


Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Ala Ala Val 
145                 150                 155                 160 


Lys Gly Tyr Arg Cys Ile Ile Val Met Pro Glu Lys Met Ser Leu Glu 
                165                 170                 175     


Lys Val Asp Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr Pro 
            180                 185                 190         


Thr Asn Ala Arg Phe Asp Ser Pro Glu Ser His Val Gly Val Ala Trp 
        195                 200                 205             


Arg Leu Lys Gln Glu Ile Pro Asn Ser His Ile Leu Asp Gln Tyr Arg 
    210                 215                 220                 


Asn Ala Ser Asn Pro Leu Ala His Tyr Asp Thr Thr Ala Glu Glu Ile 
225                 230                 235                 240 


Leu Gln Gln Cys Asp Gly Lys Leu Asp Met Leu Val Ala Ser Ala Gly 
                245                 250                 255     


Thr Gly Gly Thr Ile Thr Gly Ile Ala Arg Lys Leu Lys Glu Lys Cys 
            260                 265                 270         


Pro Gly Cys Gln Ile Ile Gly Val Asp Pro Glu Gly Ser Ile Leu Ala 
        275                 280                 285             


Glu Pro Glu Glu Leu Asn Gln Thr Glu Val Thr Ala Tyr Glu Val Glu 
    290                 295                 300                 


Gly Ile Gly Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Thr Val Val 
305                 310                 315                 320 


Asp Arg Trp Phe Lys Ser Thr Asp Lys Glu Ala Phe Ala Phe Ala Arg 
                325                 330                 335     


Met Leu Ile Ala Gln Glu Gly Leu Leu Cys Gly Gly Ser Ala Gly Ser 
            340                 345                 350         


Ala Val Ala Val Ala Val Lys Ala Ala Gln Glu Leu Gln Glu Gly Gln 
        355                 360                 365             


Arg Cys Val Val Ile Leu Pro Asp Ser Val Arg Asn Tyr Met Ser Lys 
    370                 375                 380                 


Phe Leu Ser Asp Arg Trp Met Leu Gln Lys Gly Phe Leu Glu Glu Glu 
385                 390                 395                 400 


Glu Leu Ser Val Lys Arg Pro Trp Trp Trp His Leu Arg Val Gln Glu 
                405                 410                 415     


Leu Ser Leu Ser Val Pro Leu Thr Val Leu Pro Gly Val Thr Cys Ser 
            420                 425                 430         


Asp Thr Ile Asp Ile Leu Arg Gly Lys Gly Phe Asp Gln Ala Pro Val 
        435                 440                 445             


Val Asp Glu Thr Gly Glu Ile Leu Gly Met Val Thr Leu Gly Asn Met 
    450                 455                 460                 


Leu Ser Ser Leu Leu Ala Gly Lys Val Gln Pro Ser Asp Gln Val Cys 
465                 470                 475                 480 


Lys Val Leu Tyr Lys Gln Phe Lys Gln Ile Arg Leu Thr Asp Thr Leu 
                485                 490                 495     


Gly Ala Leu Ser His Ile Leu Glu Met Asp His Phe Ala Leu Val Val 
            500                 505                 510         


His Glu Gln Ile Gln Tyr Gly Gly Asp Glu Gln Pro Ser Lys Arg Gln 
        515                 520                 525             


Thr Val Phe Gly Val Val Thr Ala Met Asp Leu Leu His Phe Val Ala 
    530                 535                 540                 


Ser Arg Gly Gln Asp Gln Gln 
545                 550     


<210> 5
<211> 464
<212> PRT
<213> Mycobacterium tuberculosis

<400> 5
Met Arg Ile Ala Gln His Ile Ser Glu Leu Ile Gly Gly Thr Pro Leu 
1               5                   10                  15      


Val Arg Leu Asn Ser Val Val Pro Asp Gly Ala Gly Thr Val Ala Ala 
            20                  25                  30          


Lys Val Glu Tyr Leu Asn Pro Gly Gly Ser Ser Lys Asp Arg Ile Ala 
        35                  40                  45              


Val Lys Met Ile Glu Ala Ala Glu Ala Ser Gly Gln Leu Lys Pro Gly 
    50                  55                  60                  


Gly Thr Ile Val Glu Pro Thr Ser Gly Asn Thr Gly Val Gly Leu Ala 
65                  70                  75                  80  


Leu Val Ala Gln Arg Arg Gly Tyr Lys Cys Val Phe Val Cys Pro Asp 
                85                  90                  95      


Lys Val Ser Glu Asp Lys Arg Asn Val Leu Ile Ala Tyr Gly Ala Glu 
            100                 105                 110         


Val Val Val Cys Pro Thr Ala Val Pro Pro His Asp Pro Ala Ser Tyr 
        115                 120                 125             


Tyr Ser Val Ser Asp Arg Leu Val Arg Asp Ile Asp Gly Ala Trp Lys 
    130                 135                 140                 


Pro Asp Gln Tyr Ala Asn Pro Glu Gly Pro Ala Ser His Tyr Val Thr 
145                 150                 155                 160 


Thr Gly Pro Glu Ile Trp Ala Asp Thr Glu Gly Lys Val Thr His Phe 
                165                 170                 175     


Val Ala Gly Ile Gly Thr Gly Gly Thr Ile Thr Gly Ala Gly Arg Tyr 
            180                 185                 190         


Leu Lys Glu Val Ser Gly Gly Arg Val Arg Ile Val Gly Ala Asp Pro 
        195                 200                 205             


Glu Gly Ser Val Tyr Ser Gly Gly Ala Gly Arg Pro Tyr Leu Val Glu 
    210                 215                 220                 


Gly Val Gly Glu Asp Phe Trp Pro Ala Ala Tyr Asp Pro Ser Val Pro 
225                 230                 235                 240 


Asp Glu Ile Ile Ala Val Ser Asp Ser Asp Ser Phe Asp Met Thr Arg 
                245                 250                 255     


Arg Leu Ala Arg Glu Glu Ala Met Leu Val Gly Gly Ser Cys Gly Met 
            260                 265                 270         


Ala Val Val Ala Ala Leu Lys Val Ala Glu Glu Ala Gly Pro Asp Ala 
        275                 280                 285             


Leu Ile Val Val Leu Leu Pro Asp Gly Gly Arg Gly Tyr Met Ser Lys 
    290                 295                 300                 


Ile Phe Asn Asp Ala Trp Met Ser Ser Tyr Gly Phe Leu Arg Ser Arg 
305                 310                 315                 320 


Leu Asp Gly Ser Thr Glu Gln Ser Thr Val Gly Asp Val Leu Arg Arg 
                325                 330                 335     


Lys Ser Gly Ala Leu Pro Ala Leu Val His Thr His Pro Ser Glu Thr 
            340                 345                 350         


Val Arg Asp Ala Ile Gly Ile Leu Arg Glu Tyr Gly Val Ser Gln Met 
        355                 360                 365             


Pro Val Val Gly Ala Glu Pro Pro Val Met Ala Gly Glu Val Ala Gly 
    370                 375                 380                 


Ser Val Ser Glu Arg Glu Leu Leu Ser Ala Val Phe Glu Gly Arg Ala 
385                 390                 395                 400 


Lys Leu Ala Asp Ala Val Ser Ala His Met Ser Pro Pro Leu Arg Met 
                405                 410                 415     


Ile Gly Ala Gly Glu Leu Val Ser Ala Ala Gly Lys Ala Leu Arg Asp 
            420                 425                 430         


Trp Asp Ala Leu Met Val Val Glu Glu Gly Lys Pro Val Gly Val Ile 
        435                 440                 445             


Thr Arg Tyr Asp Leu Leu Gly Phe Leu Ser Glu Gly Ala Gly Arg Arg 
    450                 455                 460                 


<210> 6
<211> 561
<212> PRT
<213> Rattus norvegicus

<400> 6
Met Pro Ser Gly Thr Ser Gln Cys Glu Asp Gly Ser Ala Gly Cys Pro 
1               5                   10                  15      


Gln Asp Leu Glu Val Gln Pro Glu Lys Gly Gln Leu Glu Lys Gly Ala 
            20                  25                  30          


Ser Gly Asp Lys Glu Arg Val Trp Ile Ser Pro Asp Thr Pro Ser Arg 
        35                  40                  45              


Cys Thr Trp Gln Leu Gly Arg Pro Met Ala Asp Ser Pro His Tyr His 
    50                  55                  60                  


Thr Val Pro Thr Lys Ser Pro Lys Ile Leu Pro Asp Ile Leu Arg Lys 
65                  70                  75                  80  


Ile Gly Asn Thr Pro Met Val Arg Ile Asn Arg Ile Ser Lys Asn Ala 
                85                  90                  95      


Gly Leu Lys Cys Glu Leu Leu Ala Lys Cys Glu Phe Phe Asn Ala Gly 
            100                 105                 110         


Gly Ser Val Lys Asp Arg Ile Ser Leu Arg Met Ile Glu Asp Ala Glu 
        115                 120                 125             


Arg Ala Gly Thr Leu Lys Pro Gly Asp Thr Ile Ile Glu Pro Thr Ser 
    130                 135                 140                 


Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Ala Ala Val Lys Gly Tyr 
145                 150                 155                 160 


Arg Cys Ile Ile Val Met Pro Glu Lys Met Ser Met Glu Lys Val Asp 
                165                 170                 175     


Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr Pro Thr Asn Ala 
            180                 185                 190         


Arg Phe Asp Ser Pro Glu Ser His Val Gly Val Ala Trp Arg Leu Lys 
        195                 200                 205             


Asn Glu Ile Pro Asn Ser His Ile Leu Asp Gln Tyr Arg Asn Ala Ser 
    210                 215                 220                 


Asn Pro Leu Ala His Tyr Asp Asp Thr Ala Glu Glu Ile Leu Gln Gln 
225                 230                 235                 240 


Cys Asp Gly Lys Val Asp Met Leu Val Ala Ser Ala Gly Thr Gly Gly 
                245                 250                 255     


Thr Ile Thr Gly Ile Ala Arg Lys Leu Lys Glu Lys Cys Pro Gly Cys 
            260                 265                 270         


Lys Ile Ile Gly Val Asp Pro Glu Gly Ser Ile Leu Ala Glu Pro Glu 
        275                 280                 285             


Glu Leu Asn Gln Thr Glu Gln Thr Ala Tyr Glu Val Glu Gly Ile Gly 
    290                 295                 300                 


Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Ala Val Val Asp Arg Trp 
305                 310                 315                 320 


Phe Lys Ser Asn Asp Asp Asp Ser Phe Ala Phe Ala Arg Met Leu Ile 
                325                 330                 335     


Ser Gln Glu Gly Leu Leu Cys Gly Gly Ser Ser Gly Ser Ala Met Ala 
            340                 345                 350         


Val Ala Val Lys Ala Ala Gln Glu Leu Lys Glu Gly Gln Arg Cys Val 
        355                 360                 365             


Val Ile Leu Pro Asp Ser Val Arg Asn Tyr Met Ser Lys Phe Leu Ser 
    370                 375                 380                 


Asp Lys Trp Met Leu Gln Lys Gly Phe Met Lys Glu Glu Leu Ser Val 
385                 390                 395                 400 


Lys Arg Pro Trp Trp Trp His Leu Arg Val Gln Glu Leu Ser Leu Ser 
                405                 410                 415     


Ala Pro Leu Thr Val Leu Pro Thr Val Thr Cys Glu His Thr Ile Ala 
            420                 425                 430         


Ile Leu Arg Glu Lys Gly Phe Asp Gln Ala Pro Val Val Asn Glu Ser 
        435                 440                 445             


Gly Ala Ile Leu Gly Met Val Thr Leu Gly Asn Met Leu Ser Ser Leu 
    450                 455                 460                 


Leu Ala Gly Lys Val Arg Pro Ser Asp Glu Val Cys Lys Val Leu Tyr 
465                 470                 475                 480 


Lys Gln Phe Lys Pro Ile His Leu Thr Asp Thr Leu Gly Met Leu Ser 
                485                 490                 495     


His Ile Leu Glu Met Asp His Phe Ala Leu Val Val His Glu Gln Ile 
            500                 505                 510         


Gln Ser Arg Asp Gln Ala Trp Ser Gly Val Val Gly Gly Pro Thr Asp 
        515                 520                 525             


Arg Asn Asn Gly Val Ser Ser Lys Gln Leu Met Val Phe Gly Val Val 
    530                 535                 540                 


Thr Ala Ile Asp Leu Leu Asn Phe Val Ala Ala Arg Glu Gln Thr Arg 
545                 550                 555                 560 


Lys 
    


<210> 7
<211> 498
<212> PRT
<213> Dictyostellium discoideum

<400> 7
Met Ser Ala Pro Glu Gly Pro Ser Lys Cys Thr Trp Thr Pro Asn Thr 
1               5                   10                  15      


Thr Glu Asn Thr Pro His Thr Thr Arg Arg Thr Pro Lys Lys Leu Ile 
            20                  25                  30          


Met Asp Asn Ile Leu Asp Asn Ile Gly Gly Thr Pro Leu Val Arg Val 
        35                  40                  45              


Asn Lys Val Ser Ser Asp Leu Glu Cys Glu Leu Val Ala Lys Cys Glu 
    50                  55                  60                  


Phe Phe Asn Ala Gly Gly Ser Val Lys Asp Arg Ile Gly His Arg Met 
65                  70                  75                  80  


Ile Val Asp Ala Glu Glu Ser Gly Arg Ile Lys Lys Gly Asp Thr Leu 
                85                  90                  95      


Ile Glu Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Thr Ala 
            100                 105                 110         


Ala Ile Lys Gly Tyr Lys Met Ile Ile Thr Leu Pro Glu Lys Met Ser 
        115                 120                 125             


Gln Glu Lys Val Asp Val Leu Lys Ala Leu Gly Ala Glu Ile Ile Arg 
    130                 135                 140                 


Thr Pro Thr Glu Ala Ala Phe Asp Ala Pro Glu Ser His Ile Gly Val 
145                 150                 155                 160 


Ala Lys Lys Leu Asn Ser Glu Ile Pro Asn Ser His Ile Leu Asp Gln 
                165                 170                 175     


Tyr Gly Asn Pro Ser Asn Pro Leu Ala His Tyr Asp Gly Thr Ala Glu 
            180                 185                 190         


Glu Leu Leu Glu Gln Cys Glu Gly Lys Ile Asp Met Ile Val Cys Thr 
        195                 200                 205             


Ala Gly Thr Gly Gly Thr Ile Thr Gly Ile Ala Arg Lys Ile Lys Glu 
    210                 215                 220                 


Arg Leu Pro Asn Cys Ile Val Val Gly Val Asp Pro His Gly Ser Ile 
225                 230                 235                 240 


Leu Ala Gln Pro Glu Ser Leu Asn Asn Thr Asn Lys Ser Tyr Lys Ile 
                245                 250                 255     


Glu Gly Ile Gly Tyr Asp Phe Ile Pro Asn Val Leu Glu Arg Lys Leu 
            260                 265                 270         


Val Asp Gln Trp Ile Lys Thr Asp Asp Lys Glu Ser Phe Ile Met Ala 
        275                 280                 285             


Arg Arg Leu Ile Lys Glu Glu Gly Leu Leu Cys Gly Gly Ser Ser Gly 
    290                 295                 300                 


Ser Ala Met Val Gly Ala Leu Leu Ala Ala Lys Gln Leu Lys Lys Gly 
305                 310                 315                 320 


Gln Arg Cys Val Val Leu Leu Ala Asp Ser Ile Arg Asn Tyr Met Thr 
                325                 330                 335     


Lys His Leu Asn Asp Asp Trp Leu Val Asp Asn Gly Phe Val Asp Pro 
            340                 345                 350         


Glu Tyr Lys Thr Lys Asp Gln Gln Glu Glu Glu Lys Tyr His Gly Ala 
        355                 360                 365             


Thr Val Lys Asp Leu Thr Leu Pro Lys Pro Ile Thr Ile Ser Ala Thr 
    370                 375                 380                 


Thr Thr Cys Ala Ala Ala Val Gln Leu Leu Gln Gln Tyr Gly Phe Asp 
385                 390                 395                 400 


Gln Leu Pro Val Val Ser Glu Ser Lys Lys Val Leu Gly Gln Leu Thr 
                405                 410                 415     


Leu Gly Asn Leu Leu Ser His Ile Ala Ser Lys Lys Ala Val Pro Thr 
            420                 425                 430         


Asp Ala Val Ser Lys Val Met Phe Arg Phe Thr Lys Asn Glu Lys Tyr 
        435                 440                 445             


Ile Pro Ile Thr Gln Ser Thr Ser Leu Ala Thr Leu Ser Lys Phe Phe 
    450                 455                 460                 


Glu Asn His Ser Ser Ala Ile Val Thr Glu Asn Asp Glu Ile Ile Ser 
465                 470                 475                 480 


Ile Val Thr Lys Ile Asp Leu Leu Thr Tyr Leu Met Lys Ser Gln Gln 
                485                 490                 495     


Lys Asn 
        


<210> 8
<211> 522
<212> PRT
<213> Drosophila melanogaster

<400> 8
Met Pro Gln Pro Lys Pro Tyr Glu Arg Pro Ala Asp Phe Ile Asp Pro 
1               5                   10                  15      


Gly Lys Pro Ser Lys Cys Lys Trp His Leu Gly Thr Ala Glu Lys Ser 
            20                  25                  30          


Pro His Ile His Arg Gly Ile Ala His Arg Gln Gln Ile Thr Pro Asn 
        35                  40                  45              


Ile Leu Glu Val Ile Gly Cys Thr Pro Leu Val Lys Leu Asn Asn Ile 
    50                  55                  60                  


Pro Ala Ser Asp Gly Ile Glu Cys Glu Met Tyr Ala Lys Cys Glu Phe 
65                  70                  75                  80  


Leu Asn Pro Gly Gly Ser Val Lys Asp Arg Ile Gly Tyr Arg Met Val 
                85                  90                  95      


Gln Asp Ala Glu Glu Gln Gly Leu Leu Lys Pro Gly Tyr Thr Ile Ile 
            100                 105                 110         


Glu Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Met Ala Cys Ala 
        115                 120                 125             


Val Lys Gly Tyr Lys Cys Ile Ile Val Met Pro Glu Lys Met Ser Asn 
    130                 135                 140                 


Glu Lys Val Ser Ala Leu Arg Thr Leu Gly Ala Lys Ile Ile Arg Thr 
145                 150                 155                 160 


Pro Thr Glu Ala Ala Tyr Asp Ser Pro Glu Gly Leu Ile Tyr Val Ala 
                165                 170                 175     


Gln Gln Leu Gln Arg Glu Thr Pro Asn Ser Ile Val Leu Asp Gln Tyr 
            180                 185                 190         


Arg Asn Ala Gly Asn Pro Leu Ala His Tyr Asp Gly Thr Ala Ala Glu 
        195                 200                 205             


Ile Leu Trp Gln Leu Asp Asn Lys Val Asp Met Ile Val Val Ser Ala 
    210                 215                 220                 


Gly Thr Ala Gly Thr Ile Ser Gly Ile Gly Arg Lys Ile Lys Glu Gln 
225                 230                 235                 240 


Val Pro Ser Cys Gln Ile Val Gly Val Asp Pro Tyr Gly Ser Ile Leu 
                245                 250                 255     


Ala Arg Pro Ala Glu Leu Asn Lys Thr Asp Val Gln Phe Tyr Glu Val 
            260                 265                 270         


Glu Gly Ile Gly Tyr Asp Phe Pro Pro Thr Val Phe Asp Asp Thr Val 
        275                 280                 285             


Val Asp Val Trp Thr Lys Ile Gly Asp Ser Asp Cys Phe Pro Met Ser 
    290                 295                 300                 


Arg Arg Leu Asn Ala Glu Glu Gly Leu Leu Cys Gly Gly Ser Ser Gly 
305                 310                 315                 320 


Gly Ala Met His Ala Ala Leu Glu His Ala Arg Lys Leu Lys Lys Gly 
                325                 330                 335     


Gln Arg Cys Val Val Ile Leu Pro Asp Gly Ile Arg Asn Tyr Met Thr 
            340                 345                 350         


Lys Phe Val Ser Asp Asn Trp Met Glu Ala Arg Asn Phe Lys Glu Pro 
        355                 360                 365             


Val Asn Glu His Gly His Trp Trp Trp Ser Leu Ala Ile Ala Glu Leu 
    370                 375                 380                 


Glu Leu Pro Ala Pro Pro Val Ile Leu Lys Ser Asp Ala Thr Val Gly 
385                 390                 395                 400 


Glu Ala Ile Ala Leu Met Lys Lys His Arg Val Asp Gln Leu Pro Val 
                405                 410                 415     


Val Asp Gln Asp Asp Gly Ser Val Leu Gly Val Val Gly Gln Glu Thr 
            420                 425                 430         


Leu Ile Thr Gln Ile Val Ser Met Asn Arg Gln Gln Ser Asp Pro Ala 
        435                 440                 445             


Ile Lys Ala Leu Asn Lys Arg Val Ile Arg Leu Asn Glu Ser Glu Ile 
    450                 455                 460                 


Leu Gly Lys Leu Ala Arg Val Leu Glu Val Asp Pro Ser Val Leu Ile 
465                 470                 475                 480 


Leu Gly Lys Asn Pro Ala Gly Lys Val Glu Leu Lys Ala Leu Ala Thr 
                485                 490                 495     


Lys Leu Asp Val Thr Thr Phe Ile Ala Ala Gly Lys Gln Lys Pro Lys 
            500                 505                 510         


Ala Asn Gly Thr Thr Asn Gly Gly Ser His 
        515                 520         


<210> 9
<211> 533
<212> PRT
<213> Emericella nidulan

<400> 9
Met Ser Ser Lys Thr Thr Pro Thr Val Pro Pro Val Ala Leu Asp Ser 
1               5                   10                  15      


Ile Thr Gln His Ile Gly Asn Thr Pro Leu Val Arg Leu Asn Lys Leu 
            20                  25                  30          


Pro Gln Asn Leu Gly Ile Asn Ala Thr Val Tyr Ala Lys Leu Glu Tyr 
        35                  40                  45              


Phe Asn Ala Gly Gly Ser Val Lys Asp Arg Ile Ala Leu Arg Met Ile 
    50                  55                  60                  


Glu Glu Ala Glu Arg Ser Gly Arg Ile Lys Pro Gly Asp Thr Leu Ile 
65                  70                  75                  80  


Glu Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Val Ala Ala 
                85                  90                  95      


Val Lys Gly Tyr Lys Thr Ile Ile Thr Leu Pro Glu Lys Met Ser Ala 
            100                 105                 110         


Glu Lys Val Ser Val Leu Arg Ala Leu Asn Ala Thr Ile Ile Arg Thr 
        115                 120                 125             


Pro Asn Glu Ala Ala Tyr Asp Ser Pro Glu Ser His Ile Gly Val Ala 
    130                 135                 140                 


Lys Arg Leu Glu Lys Glu Leu Pro Asn Ala His Ile Leu Asp Gln Tyr 
145                 150                 155                 160 


Gly Asn Glu Asn Asn Pro Leu Ala His Glu Leu Gly Thr Ala Gln Glu 
                165                 170                 175     


Ile Trp Ser Gln Thr Lys Gly Gln Ile Lys Ala Ile Val Ala Gly Ala 
            180                 185                 190         


Gly Thr Gly Gly Thr Ile Thr Gly Leu Ser Arg Gly Leu Lys Lys His 
        195                 200                 205             


Asn Ser Asn Val Gln Val Ile Ala Ala Asp Pro Gln Gly Ser Ile Leu 
    210                 215                 220                 


Ala Leu Pro Ala Ala Leu Asn Glu Glu His Ala Asn Glu Pro Tyr Lys 
225                 230                 235                 240 


Val Glu Gly Ile Gly Tyr Asp Phe Ile Pro Gln Val Leu Asp Gln His 
                245                 250                 255     


Ala Val Asp Lys Trp Tyr Lys Thr Asp Asp Lys Glu Ser Phe Gln Tyr 
            260                 265                 270         


Ala Arg Arg Leu Ile Ala Glu Glu Gly Leu Leu Val Gly Gly Ser Ser 
        275                 280                 285             


Gly Ser Ala Ile Ala Ala Leu Val Lys Ala Ala Arg Asp Asn Met Phe 
    290                 295                 300                 


Lys Glu Gly Asp Val Val Val Val Ile Leu Pro Asp Ser Ile Arg Ser 
305                 310                 315                 320 


Tyr Leu Thr Lys Phe Ala Asp Asp Asp Trp Leu Ala Ala Asn Asp Leu 
                325                 330                 335     


Leu Pro Ser Leu Pro Thr Glu Val Ile Leu Gln Ser Ser Asn Lys Gln 
            340                 345                 350         


Thr Gln Gly Gln Asp Asp Ala Phe Ala Gly Ser Lys Val Ser Ser Leu 
        355                 360                 365             


Arg Leu Lys Pro Val Thr Thr Val His Ser Asn Val Pro Cys Glu Thr 
    370                 375                 380                 


Ala Ile Glu Val Met Arg Asp Lys Gly Phe Asp Gln Leu Pro Val Leu 
385                 390                 395                 400 


Ala Pro Ser Gly Arg Lys Leu Val Gly Leu Val Thr Leu Gly Asn Val 
                405                 410                 415     


Leu Ser Arg Leu Thr His Asn Arg Ala Thr Gly Arg Ser Pro Val Ala 
            420                 425                 430         


Asp Val Met Phe Asp Phe Arg Thr Ile Ser Glu Val Val Thr Asp Pro 
        435                 440                 445             


Arg Asp Met Gly Leu Ala Ser Leu Glu Pro Asn Gln Asn Gly Arg Asp 
    450                 455                 460                 


Ala Pro Lys Pro Gln Thr Arg Ser Arg Lys Phe Val Glu Ile Thr Met 
465                 470                 475                 480 


Asp Thr Ser Leu Ser Val Leu Asn Arg Phe Phe Glu Trp Asn Ser Ala 
                485                 490                 495     


Ala Ile Val Thr Glu Arg Asp Glu Gly Gly Thr Leu Arg Pro Val Ala 
            500                 505                 510         


Val Val Thr Lys Val Asp Leu Leu Thr Trp Met Leu His His Lys Lys 
        515                 520                 525             


Asn Gly Ala Ser Glu 
    530             


<210> 10
<211> 566
<212> PRT
<213> Monodelphis domestica

<400> 10
Met Pro His Glu Phe Pro Gln Ile Glu Arg Glu Asn Gly Val Cys Pro 
1               5                   10                  15      


His Leu Ser Ser Asn Ser Met Glu Asn Val Ala Lys Glu Thr Ser Ser 
            20                  25                  30          


Asn Cys Gly Asn Lys Val Glu Lys Glu Arg Lys Trp Ile Arg Pro Asp 
        35                  40                  45              


Asn Pro Ser Lys Cys Thr Trp Gln Leu Gly Lys Ser Leu Ser Glu Ser 
    50                  55                  60                  


Pro His His His Val Ser Trp Thr Lys Thr Pro Lys Ile Ile Pro Asp 
65                  70                  75                  80  


Ile Leu Lys Lys Ile Gly Asp Thr Pro Met Val Arg Ile Asn Lys Ile 
                85                  90                  95      


Gly Lys Asn Phe Gly Leu Lys Cys Glu Leu Leu Ala Lys Cys Glu Phe 
            100                 105                 110         


Phe Asn Ala Gly Gly Ser Val Lys Asp Arg Ile Ser Leu Arg Met Val 
        115                 120                 125             


Glu Asp Ala Glu Arg Ala Gly Ile Leu Lys Pro Gly Asp Thr Ile Ile 
    130                 135                 140                 


Glu Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Ala Ala 
145                 150                 155                 160 


Val Lys Gly Tyr Arg Cys Ile Ile Val Met Pro Glu Lys Met Ser Met 
                165                 170                 175     


Glu Lys Val Asp Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr 
            180                 185                 190         


Pro Thr Asn Ala Arg Phe Asp Ser Pro Glu Ser His Val Gly Val Ala 
        195                 200                 205             


Trp Arg Leu Lys Asn Glu Ile Pro Asn Ser His Ile Leu Asp Gln Tyr 
    210                 215                 220                 


Arg Asn Ala Ser Asn Pro Leu Thr His Tyr Asp Ser Thr Ala Glu Glu 
225                 230                 235                 240 


Ile Leu Gln Gln Cys Asp Gly Lys Leu Asp Met Leu Val Ala Ser Ala 
                245                 250                 255     


Gly Thr Gly Gly Thr Ile Thr Gly Ile Ala Arg Lys Leu Lys Glu Lys 
            260                 265                 270         


Cys Pro Gly Cys Lys Ile Ile Gly Val Asp Pro Glu Gly Ser Ile Leu 
        275                 280                 285             


Ala Glu Pro Glu Glu Leu Asn Gln Thr Asp Lys Thr Ala Tyr Glu Val 
    290                 295                 300                 


Glu Gly Ile Gly Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Lys Val 
305                 310                 315                 320 


Val Asp Lys Trp Tyr Lys Ser Asn Asp Glu Glu Ser Phe Ala Phe Ala 
                325                 330                 335     


Arg Met Leu Ile Ala Gln Glu Gly Leu Leu Cys Gly Gly Ser Ala Gly 
            340                 345                 350         


Ser Ser Met Ser Val Ala Val Lys Ala Ala Lys Glu Leu Lys Glu Gly 
        355                 360                 365             


Gln Arg Cys Val Val Ile Leu Pro Asp Ser Val Arg Asn Tyr Met Ser 
    370                 375                 380                 


Lys Phe Leu Ser Asp Lys Trp Met Leu Gln Lys Gly Phe Val Lys Glu 
385                 390                 395                 400 


Glu Asp Ile Thr Ile Thr Lys Pro Trp Trp Trp His Leu Lys Ile Gln 
                405                 410                 415     


Glu Leu Ser Leu Ser Ala Pro Leu Thr Val Leu Pro Thr Val Thr Cys 
            420                 425                 430         


Glu Arg Thr Ile Glu Ile Leu Arg Glu Lys Gly Phe Asp Gln Val Pro 
        435                 440                 445             


Val Val Asp Glu Ser Gly Val Ile Leu Gly Met Val Thr Leu Gly Asn 
    450                 455                 460                 


Met Leu Ser Ser Leu Leu Ala Gly Lys Val Gln Pro Ser Asp Gln Val 
465                 470                 475                 480 


Arg Asn Val Ile Tyr Lys Gln Phe Arg Gln Ile His Leu Thr Asp Thr 
                485                 490                 495     


Leu Gly Met Leu Ser His Ile Leu Glu Thr Asp His Phe Ala Leu Val 
            500                 505                 510         


Val His Glu Gln Ile Gln Ser Gln Asp Gln Ser Leu Ser Glu Met Ile 
        515                 520                 525             


Gly Gly Ile Ser Asp His Ser Asn Gly Asn Ser Ile Leu Arg Gln Met 
    530                 535                 540                 


Val Phe Gly Val Val Thr Ala Ile Asp Leu Leu Asn Phe Val Ala Ala 
545                 550                 555                 560 


Arg Glu Arg Glu Gln Lys 
                565     


<210> 11
<211> 579
<212> PRT
<213> Ornithorhynchus anatinus

<400> 11
Met Pro Ser Glu Leu Ser Lys Ala Glu Glu Lys Pro Gly Val Cys Pro 
1               5                   10                  15      


His Arg Pro Gly Asn Pro Ala Glu Asn Gly Lys Ser Asp Thr Ala Arg 
            20                  25                  30          


Cys Thr Gly Leu Ser Glu Lys Glu Arg Lys Trp Ile Arg Pro Asp Met 
        35                  40                  45              


Pro Ser Lys Cys Thr Trp Gln Leu Gly Lys Pro Ala Ser Glu Ser Pro 
    50                  55                  60                  


His Tyr His Val Ser Leu Ala Gln Thr Pro Gln Ile Met Pro Asp Ile 
65                  70                  75                  80  


Leu Lys Lys Ile Gly Asn Thr Pro Leu Val Arg Ile Asn Lys Ile Gly 
                85                  90                  95      


Lys Ala Tyr Gly Leu Lys Cys Glu Leu Leu Ala Lys Cys Glu Phe Phe 
            100                 105                 110         


Asn Ala Gly Gly Ser Val Lys Asp Arg Ile Gly Leu Arg Met Leu Glu 
        115                 120                 125             


Asp Ala Glu Arg Ala Gly Ile Leu Lys Pro Gly Asp Thr Ile Ile Glu 
    130                 135                 140                 


Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Ala Ala Val 
145                 150                 155                 160 


Lys Gly Tyr Arg Cys Ile Ile Val Met Pro Glu Lys Met Ser Met Glu 
                165                 170                 175     


Lys Val Asp Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr Pro 
            180                 185                 190         


Thr Thr Ala Ser Phe Asp Ser Pro Glu Ser His Val Gly Val Ala Trp 
        195                 200                 205             


Arg Leu Lys His Glu Ile Pro Asn Ser His Ile Leu Asp Gln Tyr Arg 
    210                 215                 220                 


Asn Ala Ser Asn Pro Leu Ala His Tyr Asp Thr Thr Ala Glu Glu Ile 
225                 230                 235                 240 


Leu Gln Gln Cys Asp Gly Lys Leu Asp Met Leu Val Ala Ser Ala Gly 
                245                 250                 255     


Thr Gly Gly Thr Ile Thr Gly Ile Gly Arg Lys Leu Lys Glu Lys Cys 
            260                 265                 270         


Pro Gly Cys Lys Ile Ile Gly Val Asp Pro Glu Gly Ser Leu Leu Ala 
        275                 280                 285             


Glu Pro Glu Asp Leu Asn Lys Thr Asp Lys Thr Ile Tyr Glu Val Glu 
    290                 295                 300                 


Gly Ile Gly Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Ala Met Val 
305                 310                 315                 320 


Asp Lys Trp Tyr Lys Cys Asn Asp Glu Glu Ser Phe Ala Phe Ala Arg 
                325                 330                 335     


Met Leu Ile Ser Gln Glu Gly Leu Leu Cys Gly Trp Gly Ser Ser Gly 
            340                 345                 350         


Ser Thr Met Ser Leu Ala Val Lys Ala Ala Gln Glu Leu Lys Asp Gly 
        355                 360                 365             


Gln Arg Cys Val Phe Ile Leu Pro Asp Phe Val Gln Lys Tyr Met Ser 
    370                 375                 380                 


Lys Phe Leu Ser Asp Lys Trp Met Leu Gln Lys Gly Phe Leu Lys Glu 
385                 390                 395                 400 


Glu Asp Ile Met Ile Asn Lys Pro Trp Trp Trp His Val Lys Val Gln 
                405                 410                 415     


Glu Leu Ser Leu Ser Ala Pro Leu Thr Val Leu Pro Ala Val Thr Cys 
            420                 425                 430         


Glu Arg Thr Ile Glu Ile Leu Arg Glu Lys Gly Phe Asp Gln Val Pro 
        435                 440                 445             


Val Val Asp Glu Ser Gly Val Ile Leu Gly Met Val Thr Leu Ala Asn 
    450                 455                 460                 


Met Leu Ser Ser Leu Leu Ala Gly Lys Val Arg Pro Ser Asp Gln Val 
465                 470                 475                 480 


Arg Lys Val Ile Tyr Lys Gln Phe Gln Lys Ile Arg Leu Thr Asp Thr 
                485                 490                 495     


Leu Gly Lys Leu Ser His Ile Leu Glu Ile Asp His Phe Ala Leu Val 
            500                 505                 510         


Val His Glu Gln Ile Gln Ser Gln Asp Gln Ala Leu Pro Ala Met Val 
        515                 520                 525             


Gly Gly Thr Thr Ala Gly Ile Gln His Gly Leu Glu Asn Ser Ser Ser 
    530                 535                 540                 


Ser Ile Asp Lys Pro Glu His Arg Gly Ile Asp Leu Lys Ser Ser Tyr 
545                 550                 555                 560 


Arg Phe Ile Arg His Leu Ser Pro Glu Ser Lys His Lys Phe Asn Ala 
                565                 570                 575     


Ile Ser Ala 
            


<210> 12
<211> 387
<212> PRT
<213> Aeropyrum pernix

<400> 12
Met Ala Leu Ala Asp Ile Ser Gly Tyr Leu Asp Val Leu Asp Ser Val 
1               5                   10                  15      


Arg Gly Phe Ser Tyr Leu Glu Asn Ala Arg Glu Val Leu Arg Ser Gly 
            20                  25                  30          


Glu Ala Arg Cys Leu Gly Asn Pro Arg Ser Glu Pro Glu Tyr Val Lys 
        35                  40                  45              


Ala Leu Tyr Val Ile Gly Ala Ser Arg Ile Pro Val Asp Gly Cys Ser 
    50                  55                  60                  


His Thr Leu Glu Glu Gly Val Phe Asp Ile Ser Val Pro Gly Glu Met 
65                  70                  75                  80  


Val Phe Pro Ser Pro Leu Asp Phe Phe Glu Arg Gly Lys Pro Thr Pro 
                85                  90                  95      


Leu Val Arg Ser Arg Leu Gln Leu Pro Asn Gly Val Arg Val Trp Leu 
            100                 105                 110         


Lys Leu Glu Trp Tyr Asn Pro Phe Ser Leu Ser Val Lys Asp Arg Pro 
        115                 120                 125             


Ala Val Glu Ile Ile Ser Arg Leu Ser Arg Arg Val Glu Lys Gly Ser 
    130                 135                 140                 


Leu Val Ala Asp Ala Thr Ser Ser Asn Phe Gly Val Ala Leu Ser Ala 
145                 150                 155                 160 


Val Ala Arg Leu Tyr Gly Tyr Arg Ala Arg Val Tyr Leu Pro Gly Ala 
                165                 170                 175     


Ala Glu Glu Phe Gly Lys Leu Leu Pro Arg Leu Leu Gly Ala Gln Val 
            180                 185                 190         


Ile Val Asp Pro Glu Ala Pro Ser Thr Val His Leu Leu Pro Arg Val 
        195                 200                 205             


Met Lys Asp Ser Lys Asn Glu Gly Phe Val His Val Asn Gln Phe Tyr 
    210                 215                 220                 


Asn Asp Ala Asn Phe Glu Ala His Met Arg Gly Thr Ala Arg Glu Ile 
225                 230                 235                 240 


Phe Val Gln Ser Arg Arg Gly Gly Leu Ala Leu Arg Gly Val Ala Gly 
                245                 250                 255     


Ser Leu Gly Thr Ser Gly His Met Ser Ala Ala Ala Phe Tyr Leu Gln 
            260                 265                 270         


Ser Val Asp Pro Ser Ile Arg Ala Val Leu Val Gln Pro Ala Gln Gly 
        275                 280                 285             


Asp Ser Ile Pro Gly Ile Arg Arg Val Glu Thr Gly Met Leu Trp Ile 
    290                 295                 300                 


Asn Met Leu Asp Ile Ser Tyr Thr Leu Ala Glu Val Thr Leu Glu Glu 
305                 310                 315                 320 


Ala Met Glu Ala Val Val Glu Val Ala Arg Ser Asp Gly Leu Val Ile 
                325                 330                 335     


Gly Pro Ser Gly Gly Ala Ala Val Lys Ala Leu Ala Lys Lys Ala Ala 
            340                 345                 350         


Glu Gly Asp Leu Glu Pro Gly Asp Tyr Val Val Val Val Pro Asp Thr 
        355                 360                 365             


Gly Phe Lys Tyr Leu Ser Leu Val Gln Asn Ala Leu Glu Gly Ala Gly 
    370                 375                 380                 


Asp Ser Val 
385         


<210> 13
<211> 487
<212> PRT
<213> Homo sapiens

<400> 13
Met Met His Phe Lys Ser Gly Leu Glu Leu Thr Glu Leu Gln Asn Met 
1               5                   10                  15      


Thr Val Pro Glu Asp Asp Asn Ile Ser Asn Asp Ser Asn Asp Phe Thr 
            20                  25                  30          


Glu Val Glu Asn Gly Gln Ile Asn Ser Lys Phe Ile Ser Asp Arg Glu 
        35                  40                  45              


Ser Arg Arg Ser Leu Thr Asn Ser His Leu Glu Lys Lys Lys Cys Asp 
    50                  55                  60                  


Glu Tyr Ile Pro Gly Thr Thr Ser Leu Gly Met Ser Val Phe Asn Leu 
65                  70                  75                  80  


Ser Asn Ala Ile Met Gly Ser Gly Ile Leu Gly Leu Ala Phe Ala Leu 
                85                  90                  95      


Ala Asn Thr Gly Ile Leu Leu Phe Leu Val Leu Leu Thr Ser Val Thr 
            100                 105                 110         


Leu Leu Ser Ile Tyr Ser Ile Asn Leu Leu Leu Ile Cys Ser Lys Glu 
        115                 120                 125             


Thr Gly Cys Met Val Tyr Glu Lys Leu Gly Glu Gln Val Phe Gly Thr 
    130                 135                 140                 


Thr Gly Lys Phe Val Ile Phe Gly Ala Thr Ser Leu Gln Asn Thr Gly 
145                 150                 155                 160 


Ala Met Leu Ser Tyr Leu Phe Ile Val Lys Asn Glu Leu Pro Ser Ala 
                165                 170                 175     


Ile Lys Phe Leu Met Gly Lys Glu Glu Thr Phe Ser Ala Trp Tyr Val 
            180                 185                 190         


Asp Gly Arg Val Leu Val Val Ile Val Thr Phe Gly Ile Ile Leu Pro 
        195                 200                 205             


Leu Cys Leu Leu Lys Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Phe 
    210                 215                 220                 


Ser Leu Ser Cys Met Val Phe Phe Leu Ile Val Val Ile Tyr Lys Lys 
225                 230                 235                 240 


Phe Gln Ile Pro Cys Ile Val Pro Glu Leu Asn Ser Thr Ile Ser Ala 
                245                 250                 255     


Asn Ser Thr Asn Ala Asp Thr Cys Thr Pro Lys Tyr Val Thr Phe Asn 
            260                 265                 270         


Ser Lys Thr Val Tyr Ala Leu Pro Thr Ile Ala Phe Ala Phe Val Cys 
        275                 280                 285             


His Pro Ser Val Leu Pro Ile Tyr Ser Glu Leu Lys Asp Arg Ser Gln 
    290                 295                 300                 


Lys Lys Met Gln Met Val Ser Asn Ile Ser Phe Phe Ala Met Phe Val 
305                 310                 315                 320 


Met Tyr Phe Leu Thr Ala Ile Phe Gly Tyr Leu Thr Phe Tyr Asp Asn 
                325                 330                 335     


Val Gln Ser Asp Leu Leu His Lys Tyr Gln Ser Lys Asp Asp Ile Leu 
            340                 345                 350         


Ile Leu Thr Val Arg Leu Ala Val Ile Val Ala Val Ile Leu Thr Val 
        355                 360                 365             


Pro Val Leu Phe Phe Thr Val Arg Ser Ser Leu Phe Glu Leu Ala Lys 
    370                 375                 380                 


Lys Thr Lys Phe Asn Leu Cys Arg His Thr Val Val Thr Cys Ile Leu 
385                 390                 395                 400 


Leu Val Val Ile Asn Leu Leu Val Ile Phe Ile Pro Ser Met Lys Asp 
                405                 410                 415     


Ile Phe Gly Val Val Gly Val Thr Ser Ala Asn Met Leu Ile Phe Ile 
            420                 425                 430         


Leu Pro Ser Ser Leu Tyr Leu Lys Ile Thr Asp Gln Asp Gly Asp Lys 
        435                 440                 445             


Gly Thr Gln Arg Ile Trp Ala Ala Leu Phe Leu Gly Leu Gly Val Leu 
    450                 455                 460                 


Phe Ser Leu Val Ser Ile Pro Leu Val Ile Tyr Asp Trp Ala Cys Ser 
465                 470                 475                 480 


Ser Ser Ser Asp Glu Gly His 
                485         


<210> 14
<211> 506
<212> PRT
<213> Homo sapiens

<400> 14
Met Lys Lys Ala Glu Met Gly Arg Phe Ser Ile Ser Pro Asp Glu Asp 
1               5                   10                  15      


Ser Ser Ser Tyr Ser Ser Asn Ser Asp Phe Asn Tyr Ser Tyr Pro Thr 
            20                  25                  30          


Lys Gln Ala Ala Leu Lys Ser His Tyr Ala Asp Val Asp Pro Glu Asn 
        35                  40                  45              


Gln Asn Phe Leu Leu Glu Ser Asn Leu Gly Lys Lys Lys Tyr Glu Thr 
    50                  55                  60                  


Glu Phe His Pro Gly Thr Thr Ser Phe Gly Met Ser Val Phe Asn Leu 
65                  70                  75                  80  


Ser Asn Ala Ile Val Gly Ser Gly Ile Leu Gly Leu Ser Tyr Ala Met 
                85                  90                  95      


Ala Asn Thr Gly Ile Ala Leu Phe Ile Ile Leu Leu Thr Phe Val Ser 
            100                 105                 110         


Ile Phe Ser Leu Tyr Ser Val His Leu Leu Leu Lys Thr Ala Asn Glu 
        115                 120                 125             


Gly Gly Ser Leu Leu Tyr Glu Gln Leu Gly Tyr Lys Ala Phe Gly Leu 
    130                 135                 140                 


Val Gly Lys Leu Ala Ala Ser Gly Ser Ile Thr Met Gln Asn Ile Gly 
145                 150                 155                 160 


Ala Met Ser Ser Tyr Leu Phe Ile Val Lys Tyr Glu Leu Pro Leu Val 
                165                 170                 175     


Ile Gln Ala Leu Thr Asn Ile Glu Asp Lys Thr Gly Leu Trp Tyr Leu 
            180                 185                 190         


Asn Gly Asn Tyr Leu Val Leu Leu Val Ser Leu Val Val Ile Leu Pro 
        195                 200                 205             


Leu Ser Leu Phe Arg Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Leu 
    210                 215                 220                 


Ser Leu Leu Cys Met Val Phe Phe Leu Ile Val Val Ile Cys Lys Lys 
225                 230                 235                 240 


Phe Gln Val Pro Cys Pro Val Glu Ala Ala Leu Ile Ile Asn Glu Thr 
                245                 250                 255     


Ile Asn Thr Thr Leu Thr Gln Pro Thr Ala Leu Val Pro Ala Leu Ser 
            260                 265                 270         


His Asn Val Thr Glu Asn Asp Ser Cys Arg Pro His Tyr Phe Ile Phe 
        275                 280                 285             


Asn Ser Gln Thr Val Tyr Ala Val Pro Ile Leu Ile Phe Ser Phe Val 
    290                 295                 300                 


Cys His Pro Ala Val Leu Pro Ile Tyr Glu Glu Leu Lys Asp Arg Ser 
305                 310                 315                 320 


Arg Arg Arg Met Met Asn Val Ser Lys Ile Ser Phe Phe Ala Met Phe 
                325                 330                 335     


Leu Met Tyr Leu Leu Ala Ala Leu Phe Gly Tyr Leu Thr Phe Tyr Glu 
            340                 345                 350         


His Val Glu Ser Glu Leu Leu His Thr Tyr Ser Ser Ile Leu Gly Thr 
        355                 360                 365             


Asp Ile Leu Leu Leu Ile Val Arg Leu Ala Val Leu Met Ala Val Thr 
    370                 375                 380                 


Leu Thr Val Pro Val Val Ile Phe Pro Ile Arg Ser Ser Val Thr His 
385                 390                 395                 400 


Leu Leu Cys Ala Ser Lys Asp Phe Ser Trp Trp Arg His Ser Leu Ile 
                405                 410                 415     


Thr Val Ser Ile Leu Ala Phe Thr Asn Leu Leu Val Ile Phe Val Pro 
            420                 425                 430         


Thr Ile Arg Asp Ile Phe Gly Phe Ile Gly Ala Ser Ala Ala Ser Met 
        435                 440                 445             


Leu Ile Phe Ile Leu Pro Ser Ala Phe Tyr Ile Lys Leu Val Lys Lys 
    450                 455                 460                 


Glu Pro Met Lys Ser Val Gln Lys Ile Gly Ala Leu Phe Phe Leu Leu 
465                 470                 475                 480 


Ser Gly Val Leu Val Met Thr Gly Ser Met Ala Leu Ile Val Leu Asp 
                485                 490                 495     


Trp Val His Asn Ala Pro Gly Gly Gly His 
            500                 505     


<210> 15
<211> 547
<212> PRT
<213> Homo sapiens

<400> 15
Met Asp Pro Met Glu Leu Arg Asn Val Asn Ile Glu Pro Asp Asp Glu 
1               5                   10                  15      


Ser Ser Ser Gly Glu Ser Ala Pro Asp Ser Tyr Ile Gly Ile Gly Asn 
            20                  25                  30          


Ser Glu Lys Ala Ala Met Ser Ser Gln Phe Ala Asn Glu Asp Thr Glu 
        35                  40                  45              


Ser Gln Lys Phe Leu Thr Asn Gly Phe Leu Gly Lys Lys Lys Leu Ala 
    50                  55                  60                  


Asp Tyr Ala Asp Glu His His Pro Gly Thr Thr Ser Phe Gly Met Ser 
65                  70                  75                  80  


Ser Phe Asn Leu Ser Asn Ala Ile Met Gly Ser Gly Ile Leu Gly Leu 
                85                  90                  95      


Ser Tyr Ala Met Ala Asn Thr Gly Ile Ile Leu Phe Ile Ile Met Leu 
            100                 105                 110         


Leu Ala Val Ala Ile Leu Ser Leu Tyr Ser Val His Leu Leu Leu Lys 
        115                 120                 125             


Thr Ala Lys Glu Gly Gly Ser Leu Ile Tyr Glu Lys Leu Gly Glu Lys 
    130                 135                 140                 


Ala Phe Gly Trp Pro Gly Lys Ile Gly Ala Phe Val Ser Ile Thr Met 
145                 150                 155                 160 


Gln Asn Ile Gly Ala Met Ser Ser Tyr Leu Phe Ile Ile Lys Tyr Glu 
                165                 170                 175     


Leu Pro Glu Val Ile Arg Ala Phe Met Gly Leu Glu Glu Asn Thr Gly 
            180                 185                 190         


Glu Trp Tyr Leu Asn Gly Asn Tyr Leu Ile Ile Phe Val Ser Val Gly 
        195                 200                 205             


Ile Ile Leu Pro Leu Ser Leu Leu Lys Asn Leu Gly Tyr Leu Gly Tyr 
    210                 215                 220                 


Thr Ser Gly Phe Ser Leu Thr Cys Met Val Phe Phe Val Ser Val Val 
225                 230                 235                 240 


Ile Tyr Lys Lys Phe Gln Ile Pro Cys Pro Leu Pro Val Leu Asp His 
                245                 250                 255     


Ser Val Gly Asn Leu Ser Phe Asn Asn Thr Leu Pro Met His Val Val 
            260                 265                 270         


Met Leu Pro Asn Asn Ser Glu Ser Ser Asp Val Asn Phe Met Met Asp 
        275                 280                 285             


Tyr Thr His Arg Asn Pro Ala Gly Leu Asp Glu Asn Gln Ala Lys Gly 
    290                 295                 300                 


Ser Leu His Asp Ser Gly Val Glu Tyr Glu Ala His Ser Asp Asp Lys 
305                 310                 315                 320 


Cys Glu Pro Lys Tyr Phe Val Phe Asn Ser Arg Thr Ala Tyr Ala Ile 
                325                 330                 335     


Pro Ile Leu Val Phe Ala Phe Val Cys His Pro Glu Val Leu Pro Ile 
            340                 345                 350         


Tyr Ser Glu Leu Lys Asp Arg Ser Arg Arg Lys Met Gln Thr Val Ser 
        355                 360                 365             


Asn Ile Ser Ile Thr Gly Met Leu Val Met Tyr Leu Leu Ala Ala Leu 
    370                 375                 380                 


Phe Gly Tyr Leu Thr Phe Tyr Gly Glu Val Glu Asp Glu Leu Leu His 
385                 390                 395                 400 


Ala Tyr Ser Lys Val Tyr Thr Leu Asp Ile Pro Leu Leu Met Val Arg 
                405                 410                 415     


Leu Ala Val Leu Val Ala Val Thr Leu Thr Val Pro Ile Val Leu Phe 
            420                 425                 430         


Pro Ile Arg Thr Ser Val Ile Thr Leu Leu Phe Pro Lys Arg Pro Phe 
        435                 440                 445             


Ser Trp Ile Arg His Phe Leu Ile Ala Ala Val Leu Ile Ala Leu Asn 
    450                 455                 460                 


Asn Val Leu Val Ile Leu Val Pro Thr Ile Lys Tyr Ile Phe Gly Phe 
465                 470                 475                 480 


Ile Gly Ala Ser Ser Ala Thr Met Leu Ile Phe Ile Leu Pro Ala Val 
                485                 490                 495     


Phe Tyr Leu Lys Leu Val Lys Lys Glu Thr Phe Arg Ser Pro Gln Lys 
            500                 505                 510         


Val Gly Ala Leu Ile Phe Leu Val Val Gly Ile Phe Phe Met Ile Gly 
        515                 520                 525             


Ser Met Ala Leu Ile Ile Ile Asp Trp Ile Tyr Asp Pro Pro Asn Ser 
    530                 535                 540                 


Lys His His 
545         


<210> 16
<211> 532
<212> PRT
<213> Homo sapiens

<400> 16
Met Glu Lys Ser Asn Glu Thr Asn Gly Tyr Leu Asp Ser Ala Gln Ala 
1               5                   10                  15      


Gly Pro Ala Ala Gly Pro Gly Ala Pro Gly Thr Ala Ala Gly Arg Ala 
            20                  25                  30          


Arg Arg Cys Ala Gly Phe Leu Arg Arg Gln Ala Leu Val Leu Leu Thr 
        35                  40                  45              


Val Ser Gly Val Leu Ala Gly Ala Gly Leu Gly Ala Ala Leu Arg Gly 
    50                  55                  60                  


Leu Ser Leu Ser Arg Thr Gln Val Thr Tyr Leu Ala Phe Pro Gly Glu 
65                  70                  75                  80  


Met Leu Leu Arg Met Leu Arg Met Ile Ile Leu Pro Leu Val Val Cys 
                85                  90                  95      


Ser Leu Val Ser Gly Ala Ala Ser Leu Asp Ala Ser Cys Leu Gly Arg 
            100                 105                 110         


Leu Gly Gly Ile Ala Val Ala Tyr Phe Gly Leu Thr Thr Leu Ser Ala 
        115                 120                 125             


Ser Ala Leu Ala Val Ala Leu Ala Phe Ile Ile Lys Pro Gly Ser Gly 
    130                 135                 140                 


Ala Gln Thr Leu Gln Ser Ser Asp Leu Gly Leu Glu Asp Ser Gly Pro 
145                 150                 155                 160 


Pro Pro Val Pro Lys Glu Thr Val Asp Ser Phe Leu Asp Leu Ala Arg 
                165                 170                 175     


Asn Leu Phe Pro Ser Asn Leu Val Val Ala Ala Phe Arg Thr Tyr Ala 
            180                 185                 190         


Thr Asp Tyr Lys Val Val Thr Gln Asn Ser Ser Ser Gly Asn Val Thr 
        195                 200                 205             


His Glu Lys Ile Pro Ile Gly Thr Glu Ile Glu Gly Met Asn Ile Leu 
    210                 215                 220                 


Gly Leu Val Leu Phe Ala Leu Val Leu Gly Val Ala Leu Lys Lys Leu 
225                 230                 235                 240 


Gly Ser Glu Gly Glu Asp Leu Ile Arg Phe Phe Asn Ser Leu Asn Glu 
                245                 250                 255     


Ala Thr Met Val Leu Val Ser Trp Ile Met Trp Tyr Val Pro Val Gly 
            260                 265                 270         


Ile Met Phe Leu Val Gly Ser Lys Ile Val Glu Met Lys Asp Ile Ile 
        275                 280                 285             


Val Leu Val Thr Ser Leu Gly Lys Tyr Ile Phe Ala Ser Ile Leu Gly 
    290                 295                 300                 


His Val Ile His Gly Gly Ile Val Leu Pro Leu Ile Tyr Phe Val Phe 
305                 310                 315                 320 


Thr Arg Lys Asn Pro Phe Arg Phe Leu Leu Gly Leu Leu Ala Pro Phe 
                325                 330                 335     


Ala Thr Ala Phe Ala Thr Cys Ser Ser Ser Ala Thr Leu Pro Ser Met 
            340                 345                 350         


Met Lys Cys Ile Glu Glu Asn Asn Gly Val Asp Lys Arg Ile Ser Arg 
        355                 360                 365             


Phe Ile Leu Pro Ile Gly Ala Thr Val Asn Met Asp Gly Ala Ala Ile 
    370                 375                 380                 


Phe Gln Cys Val Ala Ala Val Phe Ile Ala Gln Leu Asn Asn Val Glu 
385                 390                 395                 400 


Leu Asn Ala Gly Gln Ile Phe Thr Ile Leu Val Thr Ala Thr Ala Ser 
                405                 410                 415     


Ser Val Gly Ala Ala Gly Val Pro Ala Gly Gly Val Leu Thr Ile Ala 
            420                 425                 430         


Ile Ile Leu Glu Ala Ile Gly Leu Pro Thr His Asp Leu Pro Leu Ile 
        435                 440                 445             


Leu Ala Val Asp Trp Ile Val Asp Arg Thr Thr Thr Val Val Asn Val 
    450                 455                 460                 


Glu Gly Asp Ala Leu Gly Ala Gly Ile Leu His His Leu Asn Gln Lys 
465                 470                 475                 480 


Ala Thr Lys Lys Gly Glu Gln Glu Leu Ala Glu Val Lys Val Glu Ala 
                485                 490                 495     


Ile Pro Asn Cys Lys Ser Glu Glu Glu Thr Ser Pro Leu Val Thr His 
            500                 505                 510         


Gln Asn Pro Ala Gly Pro Val Ala Ser Ala Pro Glu Leu Glu Ser Lys 
        515                 520                 525             


Glu Ser Val Leu 
    530         


<210> 17
<211> 541
<212> PRT
<213> Homo sapiens

<400> 17
Met Val Ala Asp Pro Pro Arg Asp Ser Lys Gly Leu Ala Ala Ala Glu 
1               5                   10                  15      


Pro Thr Ala Asn Gly Gly Leu Ala Leu Ala Ser Ile Glu Asp Gln Gly 
            20                  25                  30          


Ala Ala Ala Gly Gly Tyr Cys Gly Ser Arg Asp Gln Val Arg Arg Cys 
        35                  40                  45              


Leu Arg Ala Asn Leu Leu Val Leu Leu Thr Val Val Ala Val Val Ala 
    50                  55                  60                  


Gly Val Ala Leu Gly Leu Gly Val Ser Gly Ala Gly Gly Ala Leu Ala 
65                  70                  75                  80  


Leu Gly Pro Glu Arg Leu Ser Ala Phe Val Phe Pro Gly Glu Leu Leu 
                85                  90                  95      


Leu Arg Leu Leu Arg Met Ile Ile Leu Pro Leu Val Val Cys Ser Leu 
            100                 105                 110         


Ile Gly Gly Ala Ala Ser Leu Asp Pro Gly Ala Leu Gly Arg Leu Gly 
        115                 120                 125             


Ala Trp Ala Leu Leu Phe Phe Leu Val Thr Thr Leu Leu Ala Ser Ala 
    130                 135                 140                 


Leu Gly Val Gly Leu Ala Leu Ala Leu Gln Pro Gly Ala Ala Ser Ala 
145                 150                 155                 160 


Ala Ile Asn Ala Ser Val Gly Ala Ala Gly Ser Ala Glu Asn Ala Pro 
                165                 170                 175     


Ser Lys Glu Val Leu Asp Ser Phe Leu Asp Leu Ala Arg Asn Ile Phe 
            180                 185                 190         


Pro Ser Asn Leu Val Ser Ala Ala Phe Arg Ser Tyr Ser Thr Thr Tyr 
        195                 200                 205             


Glu Glu Arg Asn Ile Thr Gly Thr Arg Val Lys Val Pro Val Gly Gln 
    210                 215                 220                 


Glu Val Glu Gly Met Asn Ile Leu Gly Leu Val Val Phe Ala Ile Val 
225                 230                 235                 240 


Phe Gly Val Ala Leu Arg Lys Leu Gly Pro Glu Gly Glu Leu Leu Ile 
                245                 250                 255     


Arg Phe Phe Asn Ser Phe Asn Glu Ala Thr Met Val Leu Val Ser Trp 
            260                 265                 270         


Ile Met Trp Tyr Ala Pro Val Gly Ile Met Phe Leu Val Ala Gly Lys 
        275                 280                 285             


Ile Val Glu Met Glu Asp Val Gly Leu Leu Phe Ala Arg Leu Gly Lys 
    290                 295                 300                 


Tyr Ile Leu Cys Cys Leu Leu Gly His Ala Ile His Gly Leu Leu Val 
305                 310                 315                 320 


Leu Pro Leu Ile Tyr Phe Leu Phe Thr Arg Lys Asn Pro Tyr Arg Phe 
                325                 330                 335     


Leu Trp Gly Ile Val Thr Pro Leu Ala Thr Ala Phe Gly Thr Ser Ser 
            340                 345                 350         


Ser Ser Ala Thr Leu Pro Leu Met Met Lys Cys Val Glu Glu Asn Asn 
        355                 360                 365             


Gly Val Ala Lys His Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr 
    370                 375                 380                 


Val Asn Met Asp Gly Ala Ala Leu Phe Gln Cys Val Ala Ala Val Phe 
385                 390                 395                 400 


Ile Ala Gln Leu Ser Gln Gln Ser Leu Asp Phe Val Lys Ile Ile Thr 
                405                 410                 415     


Ile Leu Val Thr Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Ile Pro 
            420                 425                 430         


Ala Gly Gly Val Leu Thr Leu Ala Ile Ile Leu Glu Ala Val Asn Leu 
        435                 440                 445             


Pro Val Asp His Ile Ser Leu Ile Leu Ala Val Asp Trp Leu Val Asp 
    450                 455                 460                 


Arg Ser Cys Thr Val Leu Asn Val Glu Gly Asp Ala Leu Gly Ala Gly 
465                 470                 475                 480 


Leu Leu Gln Asn Tyr Val Asp Arg Thr Glu Ser Arg Ser Thr Glu Pro 
                485                 490                 495     


Glu Leu Ile Gln Val Lys Ser Glu Leu Pro Leu Asp Pro Leu Pro Val 
            500                 505                 510         


Pro Thr Glu Glu Gly Asn Pro Leu Leu Lys His Tyr Arg Gly Pro Ala 
        515                 520                 525             


Gly Asp Ala Thr Val Ala Ser Glu Lys Glu Ser Val Met 
    530                 535                 540     


<210> 18
<211> 507
<212> PRT
<213> Homo sapiens

<400> 18
Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Ala Ala 
1               5                   10                  15      


Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ala Lys Ser Ala 
            20                  25                  30          


Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg 
        35                  40                  45              


Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Thr Ile Ile 
    50                  55                  60                  


Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly 
65                  70                  75                  80  


Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser 
                85                  90                  95      


Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys 
            100                 105                 110         


Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro 
        115                 120                 125             


Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser 
    130                 135                 140                 


Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu 
145                 150                 155                 160 


Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys 
                165                 170                 175     


Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala 
            180                 185                 190         


Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu 
        195                 200                 205             


Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val 
    210                 215                 220                 


Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val 
225                 230                 235                 240 


Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly 
                245                 250                 255     


Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg 
            260                 265                 270         


Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val 
        275                 280                 285             


Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln 
    290                 295                 300                 


Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu 
305                 310                 315                 320 


Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe 
                325                 330                 335     


Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val 
            340                 345                 350         


Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro 
        355                 360                 365             


Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr 
    370                 375                 380                 


Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe 
385                 390                 395                 400 


Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile 
                405                 410                 415     


Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn 
            420                 425                 430         


Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala 
        435                 440                 445             


Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile 
    450                 455                 460                 


Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn 
465                 470                 475                 480 


Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys 
                485                 490                 495     


Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr 
            500                 505         


<210> 19
<211> 535
<212> PRT
<213> Homo sapiens

<400> 19
Met Glu Glu Gly Ala Arg His Arg Asn Asn Thr Glu Lys Lys His Pro 
1               5                   10                  15      


Gly Gly Gly Glu Ser Asp Ala Ser Pro Glu Ala Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Val Ala Leu Lys Lys Glu Ile Gly Leu Val Ser Ala Cys Gly Ile 
        35                  40                  45              


Ile Val Gly Asn Ile Ile Gly Ser Gly Ile Phe Val Ser Pro Lys Gly 
    50                  55                  60                  


Val Leu Glu Asn Ala Gly Ser Val Gly Leu Ala Leu Ile Val Trp Ile 
65                  70                  75                  80  


Val Thr Gly Phe Ile Thr Val Val Gly Ala Leu Cys Tyr Ala Glu Leu 
                85                  90                  95      


Gly Val Thr Ile Pro Lys Ser Gly Gly Asp Tyr Ser Tyr Val Lys Asp 
            100                 105                 110         


Ile Phe Gly Gly Leu Ala Gly Phe Leu Arg Leu Trp Ile Ala Val Leu 
        115                 120                 125             


Val Ile Tyr Pro Thr Asn Gln Ala Val Ile Ala Leu Thr Phe Ser Asn 
    130                 135                 140                 


Tyr Val Leu Gln Pro Leu Phe Pro Thr Cys Phe Pro Pro Glu Ser Gly 
145                 150                 155                 160 


Leu Arg Leu Leu Ala Ala Ile Cys Leu Leu Leu Leu Thr Trp Val Asn 
                165                 170                 175     


Cys Ser Ser Val Arg Trp Ala Thr Arg Val Gln Asp Ile Phe Thr Ala 
            180                 185                 190         


Gly Lys Leu Leu Ala Leu Ala Leu Ile Ile Ile Met Gly Ile Val Gln 
        195                 200                 205             


Ile Cys Lys Gly Glu Tyr Phe Trp Leu Glu Pro Lys Asn Ala Phe Glu 
    210                 215                 220                 


Asn Phe Gln Glu Pro Asp Ile Gly Leu Val Ala Leu Ala Phe Leu Gln 
225                 230                 235                 240 


Gly Ser Phe Ala Tyr Gly Gly Trp Asn Phe Leu Asn Tyr Val Thr Glu 
                245                 250                 255     


Glu Leu Val Asp Pro Tyr Lys Asn Leu Pro Arg Ala Ile Phe Ile Ser 
            260                 265                 270         


Ile Pro Leu Val Thr Phe Val Tyr Val Phe Ala Asn Val Ala Tyr Val 
        275                 280                 285             


Thr Ala Met Ser Pro Gln Glu Leu Leu Ala Ser Asn Ala Val Ala Val 
    290                 295                 300                 


Thr Phe Gly Glu Lys Leu Leu Gly Val Met Ala Trp Ile Met Pro Ile 
305                 310                 315                 320 


Ser Val Ala Leu Ser Thr Phe Gly Gly Val Asn Gly Ser Leu Phe Thr 
                325                 330                 335     


Ser Ser Arg Leu Phe Phe Ala Gly Ala Arg Glu Gly His Leu Pro Ser 
            340                 345                 350         


Val Leu Ala Met Ile His Val Lys Arg Cys Thr Pro Ile Pro Ala Leu 
        355                 360                 365             


Leu Phe Thr Cys Ile Ser Thr Leu Leu Met Leu Val Thr Ser Asp Met 
    370                 375                 380                 


Tyr Thr Leu Ile Asn Tyr Val Gly Phe Ile Asn Tyr Leu Phe Tyr Gly 
385                 390                 395                 400 


Val Thr Val Ala Gly Gln Ile Val Leu Arg Trp Lys Lys Pro Asp Ile 
                405                 410                 415     


Pro Arg Pro Ile Lys Ile Asn Leu Leu Phe Pro Ile Ile Tyr Leu Leu 
            420                 425                 430         


Phe Trp Ala Phe Leu Leu Val Phe Ser Leu Trp Ser Glu Pro Val Val 
        435                 440                 445             


Cys Gly Ile Gly Leu Ala Ile Met Leu Thr Gly Val Pro Val Tyr Phe 
    450                 455                 460                 


Leu Gly Val Tyr Trp Gln His Lys Pro Lys Cys Phe Ser Asp Phe Ile 
465                 470                 475                 480 


Glu Leu Leu Thr Leu Val Ser Gln Lys Met Cys Val Val Val Tyr Pro 
                485                 490                 495     


Glu Val Glu Arg Gly Ser Gly Thr Glu Glu Ala Asn Glu Asp Met Glu 
            500                 505                 510         


Glu Gln Gln Gln Pro Met Tyr Gln Pro Thr Pro Thr Lys Asp Lys Asp 
        515                 520                 525             


Val Ala Gly Gln Pro Gln Pro 
    530                 535 


<210> 20
<211> 542
<212> PRT
<213> Homo sapiens

<400> 20
Met Thr Lys Ser Asn Gly Glu Glu Pro Lys Met Gly Gly Arg Met Glu 
1               5                   10                  15      


Arg Phe Gln Gln Gly Val Arg Lys Arg Thr Leu Leu Ala Lys Lys Lys 
            20                  25                  30          


Val Gln Asn Ile Thr Lys Glu Asp Val Lys Ser Tyr Leu Phe Arg Asn 
        35                  40                  45              


Ala Phe Val Leu Leu Thr Val Thr Ala Val Ile Val Gly Thr Ile Leu 
    50                  55                  60                  


Gly Phe Thr Leu Arg Pro Tyr Arg Met Ser Tyr Arg Glu Val Lys Tyr 
65                  70                  75                  80  


Phe Ser Phe Pro Gly Glu Leu Leu Met Arg Met Leu Gln Met Leu Val 
                85                  90                  95      


Leu Pro Leu Ile Ile Ser Ser Leu Val Thr Gly Met Ala Ala Leu Asp 
            100                 105                 110         


Ser Lys Ala Ser Gly Lys Met Gly Met Arg Ala Val Val Tyr Tyr Met 
        115                 120                 125             


Thr Thr Thr Ile Ile Ala Val Val Ile Gly Ile Ile Ile Val Ile Ile 
    130                 135                 140                 


Ile His Pro Gly Lys Gly Thr Lys Glu Asn Met His Arg Glu Gly Lys 
145                 150                 155                 160 


Ile Val Arg Val Thr Ala Ala Asp Ala Phe Leu Asp Leu Ile Arg Asn 
                165                 170                 175     


Met Phe Pro Pro Asn Leu Val Glu Ala Cys Phe Lys Gln Phe Lys Thr 
            180                 185                 190         


Asn Tyr Glu Lys Arg Ser Phe Lys Val Pro Ile Gln Ala Asn Glu Thr 
        195                 200                 205             


Leu Val Gly Ala Val Ile Asn Asn Val Ser Glu Ala Met Glu Thr Leu 
    210                 215                 220                 


Thr Arg Ile Thr Glu Glu Leu Val Pro Val Pro Gly Ser Val Asn Gly 
225                 230                 235                 240 


Val Asn Ala Leu Gly Leu Val Val Phe Ser Met Cys Phe Gly Phe Val 
                245                 250                 255     


Ile Gly Asn Met Lys Glu Gln Gly Gln Ala Leu Arg Glu Phe Phe Asp 
            260                 265                 270         


Ser Leu Asn Glu Ala Ile Met Arg Leu Val Ala Val Ile Met Trp Tyr 
        275                 280                 285             


Ala Pro Val Gly Ile Leu Phe Leu Ile Ala Gly Lys Ile Val Glu Met 
    290                 295                 300                 


Glu Asp Met Gly Val Ile Gly Gly Gln Leu Ala Met Tyr Thr Val Thr 
305                 310                 315                 320 


Val Ile Val Gly Leu Leu Ile His Ala Val Ile Val Leu Pro Leu Leu 
                325                 330                 335     


Tyr Phe Leu Val Thr Arg Lys Asn Pro Trp Val Phe Ile Gly Gly Leu 
            340                 345                 350         


Leu Gln Ala Leu Ile Thr Ala Leu Gly Thr Ser Ser Ser Ser Ala Thr 
        355                 360                 365             


Leu Pro Ile Thr Phe Lys Cys Leu Glu Glu Asn Asn Gly Val Asp Lys 
    370                 375                 380                 


Arg Val Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp 
385                 390                 395                 400 


Gly Thr Ala Leu Tyr Glu Ala Leu Ala Ala Ile Phe Ile Ala Gln Val 
                405                 410                 415     


Asn Asn Phe Glu Leu Asn Phe Gly Gln Ile Ile Thr Ile Ser Ile Thr 
            420                 425                 430         


Ala Thr Ala Ala Ser Ile Gly Ala Ala Gly Ile Pro Gln Ala Gly Leu 
        435                 440                 445             


Val Thr Met Val Ile Val Leu Thr Ser Val Gly Leu Pro Thr Asp Asp 
    450                 455                 460                 


Ile Thr Leu Ile Ile Ala Val Asp Trp Phe Leu Asp Arg Leu Arg Thr 
465                 470                 475                 480 


Thr Thr Asn Val Leu Gly Asp Ser Leu Gly Ala Gly Ile Val Glu His 
                485                 490                 495     


Leu Ser Arg His Glu Leu Lys Asn Arg Asp Val Glu Met Gly Asn Ser 
            500                 505                 510         


Val Ile Glu Glu Asn Glu Met Lys Lys Pro Tyr Gln Leu Ile Ala Gln 
        515                 520                 525             


Asp Asn Glu Thr Glu Lys Pro Ile Asp Ser Glu Thr Lys Met 
    530                 535                 540         


<210> 21
<211> 574
<212> PRT
<213> Homo sapiens

<400> 21
Met Ala Ser Thr Glu Gly Ala Asn Asn Met Pro Lys Gln Val Glu Val 
1               5                   10                  15      


Arg Met His Asp Ser His Leu Gly Ser Glu Glu Pro Lys His Arg His 
            20                  25                  30          


Leu Gly Leu Arg Leu Cys Asp Lys Leu Gly Lys Asn Leu Leu Leu Thr 
        35                  40                  45              


Leu Thr Val Phe Gly Val Ile Leu Gly Ala Val Cys Gly Gly Leu Leu 
    50                  55                  60                  


Arg Leu Ala Ser Pro Ile His Pro Asp Val Val Met Leu Ile Ala Phe 
65                  70                  75                  80  


Pro Gly Asp Ile Leu Met Arg Met Leu Lys Met Leu Ile Leu Pro Leu 
                85                  90                  95      


Ile Ile Ser Ser Leu Ile Thr Gly Leu Ser Gly Leu Asp Ala Lys Ala 
            100                 105                 110         


Ser Gly Arg Leu Gly Thr Arg Ala Met Val Tyr Tyr Met Ser Thr Thr 
        115                 120                 125             


Ile Ile Ala Ala Val Leu Gly Val Ile Leu Val Leu Ala Ile His Pro 
    130                 135                 140                 


Gly Asn Pro Lys Leu Lys Lys Gln Leu Gly Pro Gly Lys Lys Asn Asp 
145                 150                 155                 160 


Glu Val Ser Ser Leu Asp Ala Phe Leu Asp Leu Ile Arg Asn Leu Phe 
                165                 170                 175     


Pro Glu Asn Leu Val Gln Ala Cys Phe Gln Gln Ile Gln Thr Val Thr 
            180                 185                 190         


Lys Lys Val Leu Val Ala Pro Pro Pro Asp Glu Glu Ala Asn Ala Thr 
        195                 200                 205             


Ser Ala Val Val Ser Leu Leu Asn Glu Thr Val Thr Glu Val Pro Glu 
    210                 215                 220                 


Glu Thr Lys Met Val Ile Lys Lys Gly Leu Glu Phe Lys Asp Gly Met 
225                 230                 235                 240 


Asn Val Leu Gly Leu Ile Gly Phe Phe Ile Ala Phe Gly Ile Ala Met 
                245                 250                 255     


Gly Lys Met Gly Asp Gln Ala Lys Leu Met Val Asp Phe Phe Asn Ile 
            260                 265                 270         


Leu Asn Glu Ile Val Met Lys Leu Val Ile Met Ile Met Trp Tyr Ser 
        275                 280                 285             


Pro Leu Gly Ile Ala Cys Leu Ile Cys Gly Lys Ile Ile Ala Ile Lys 
    290                 295                 300                 


Asp Leu Glu Val Val Ala Arg Gln Leu Gly Met Tyr Met Val Thr Val 
305                 310                 315                 320 


Ile Ile Gly Leu Ile Ile His Gly Gly Ile Phe Leu Pro Leu Ile Tyr 
                325                 330                 335     


Phe Val Val Thr Arg Lys Asn Pro Phe Ser Phe Phe Ala Gly Ile Phe 
            340                 345                 350         


Gln Ala Trp Ile Thr Ala Leu Gly Thr Ala Ser Ser Ala Gly Thr Leu 
        355                 360                 365             


Pro Val Thr Phe Arg Cys Leu Glu Glu Asn Leu Gly Ile Asp Lys Arg 
    370                 375                 380                 


Val Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp Gly 
385                 390                 395                 400 


Thr Ala Leu Tyr Glu Ala Val Ala Ala Ile Phe Ile Ala Gln Met Asn 
                405                 410                 415     


Gly Val Val Leu Asp Gly Gly Gln Ile Val Thr Val Ser Leu Thr Ala 
            420                 425                 430         


Thr Leu Ala Ser Val Gly Ala Ala Ser Ile Pro Ser Ala Gly Leu Val 
        435                 440                 445             


Thr Met Leu Leu Ile Leu Thr Ala Val Gly Leu Pro Thr Glu Asp Ile 
    450                 455                 460                 


Ser Leu Leu Val Ala Val Asp Trp Leu Leu Asp Arg Met Arg Thr Ser 
465                 470                 475                 480 


Val Asn Val Val Gly Asp Ser Phe Gly Ala Gly Ile Val Tyr His Leu 
                485                 490                 495     


Ser Lys Ser Glu Leu Asp Thr Ile Asp Ser Gln His Arg Val His Glu 
            500                 505                 510         


Asp Ile Glu Met Thr Lys Thr Gln Ser Ile Tyr Asp Asp Met Lys Asn 
        515                 520                 525             


His Arg Glu Ser Asn Ser Asn Gln Cys Val Tyr Ala Ala His Asn Ser 
    530                 535                 540                 


Val Ile Val Asp Glu Cys Lys Val Thr Leu Ala Ala Asn Gly Lys Ser 
545                 550                 555                 560 


Ala Asp Cys Ser Val Glu Glu Glu Pro Trp Lys Arg Glu Lys 
                565                 570                 


<210> 22
<211> 524
<212> PRT
<213> Homo sapiens

<400> 22
Met Gly Lys Pro Ala Arg Lys Gly Cys Glu Trp Lys Arg Phe Leu Lys 
1               5                   10                  15      


Asn Asn Trp Val Leu Leu Ser Thr Val Ala Ala Val Val Leu Gly Ile 
            20                  25                  30          


Thr Thr Gly Val Leu Val Arg Glu His Ser Asn Leu Ser Thr Leu Glu 
        35                  40                  45              


Lys Phe Tyr Phe Ala Phe Pro Gly Glu Ile Leu Met Arg Met Leu Lys 
    50                  55                  60                  


Leu Ile Ile Leu Pro Leu Ile Ile Ser Ser Met Ile Thr Gly Val Ala 
65                  70                  75                  80  


Ala Leu Asp Ser Asn Val Ser Gly Lys Ile Gly Leu Arg Ala Val Val 
                85                  90                  95      


Tyr Tyr Phe Cys Thr Thr Leu Ile Ala Val Ile Leu Gly Ile Val Leu 
            100                 105                 110         


Val Val Ser Ile Lys Pro Gly Val Thr Gln Lys Val Gly Glu Ile Ala 
        115                 120                 125             


Arg Thr Gly Ser Thr Pro Glu Val Ser Thr Val Asp Ala Met Leu Asp 
    130                 135                 140                 


Leu Ile Arg Asn Met Phe Pro Glu Asn Leu Val Gln Ala Cys Phe Gln 
145                 150                 155                 160 


Gln Tyr Lys Thr Lys Arg Glu Glu Val Lys Pro Pro Ser Asp Pro Glu 
                165                 170                 175     


Met Asn Met Thr Glu Glu Ser Phe Thr Ala Val Met Thr Thr Ala Ile 
            180                 185                 190         


Ser Lys Asn Lys Thr Lys Glu Tyr Lys Ile Val Gly Met Tyr Ser Asp 
        195                 200                 205             


Gly Ile Asn Val Leu Gly Leu Ile Val Phe Cys Leu Val Phe Gly Leu 
    210                 215                 220                 


Val Ile Gly Lys Met Gly Glu Lys Gly Gln Ile Leu Val Asp Phe Phe 
225                 230                 235                 240 


Asn Ala Leu Ser Asp Ala Thr Met Lys Ile Val Gln Ile Ile Met Cys 
                245                 250                 255     


Tyr Met Pro Leu Gly Ile Leu Phe Leu Ile Ala Gly Lys Ile Ile Glu 
            260                 265                 270         


Val Glu Asp Trp Glu Ile Phe Arg Lys Leu Gly Leu Tyr Met Ala Thr 
        275                 280                 285             


Val Leu Thr Gly Leu Ala Ile His Ser Ile Val Ile Leu Pro Leu Ile 
    290                 295                 300                 


Tyr Phe Ile Val Val Arg Lys Asn Pro Phe Arg Phe Ala Met Gly Met 
305                 310                 315                 320 


Ala Gln Ala Leu Leu Thr Ala Leu Met Ile Ser Ser Ser Ser Ala Thr 
                325                 330                 335     


Leu Pro Val Thr Phe Arg Cys Ala Glu Glu Asn Asn Gln Val Asp Lys 
            340                 345                 350         


Arg Ile Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp 
        355                 360                 365             


Gly Thr Ala Leu Tyr Glu Ala Val Ala Ala Val Phe Ile Ala Gln Leu 
    370                 375                 380                 


Asn Asp Leu Asp Leu Gly Ile Gly Gln Ile Ile Thr Ile Ser Ile Thr 
385                 390                 395                 400 


Ala Thr Ser Ala Ser Ile Gly Ala Ala Gly Val Pro Gln Ala Gly Leu 
                405                 410                 415     


Val Thr Met Val Ile Val Leu Ser Ala Val Gly Leu Pro Ala Glu Asp 
            420                 425                 430         


Val Thr Leu Ile Ile Ala Val Asp Trp Leu Leu Asp Arg Phe Arg Thr 
        435                 440                 445             


Met Val Asn Val Leu Gly Asp Ala Phe Gly Thr Gly Ile Val Glu Lys 
    450                 455                 460                 


Leu Ser Lys Lys Glu Leu Glu Gln Met Asp Val Ser Ser Glu Val Asn 
465                 470                 475                 480 


Ile Val Asn Pro Phe Ala Leu Glu Ser Thr Ile Leu Asp Asn Glu Asp 
                485                 490                 495     


Ser Asp Thr Lys Lys Ser Tyr Val Asn Gly Gly Phe Ala Val Asp Lys 
            500                 505                 510         


Ser Asp Thr Ile Ser Phe Thr Gln Thr Ser Gln Phe 
        515                 520                 


<210> 23
<211> 564
<212> PRT
<213> Homo sapiens

<400> 23
Met Ser Ser His Gly Asn Ser Leu Phe Leu Arg Glu Ser Gly Gln Arg 
1               5                   10                  15      


Leu Gly Arg Val Gly Trp Leu Gln Arg Leu Gln Glu Ser Leu Gln Gln 
            20                  25                  30          


Arg Ala Leu Arg Thr Arg Leu Arg Leu Gln Thr Met Thr Leu Glu His 
        35                  40                  45              


Val Leu Arg Phe Leu Arg Arg Asn Ala Phe Ile Leu Leu Thr Val Ser 
    50                  55                  60                  


Ala Val Val Ile Gly Val Ser Leu Ala Phe Ala Leu Arg Pro Tyr Gln 
65                  70                  75                  80  


Leu Thr Tyr Arg Gln Ile Lys Tyr Phe Ser Phe Pro Gly Glu Leu Leu 
                85                  90                  95      


Met Arg Met Leu Gln Met Leu Val Leu Pro Leu Ile Val Ser Ser Leu 
            100                 105                 110         


Val Thr Gly Met Ala Ser Leu Asp Asn Lys Ala Thr Gly Arg Met Gly 
        115                 120                 125             


Met Arg Ala Ala Val Tyr Tyr Met Val Thr Thr Ile Ile Ala Val Phe 
    130                 135                 140                 


Ile Gly Ile Leu Met Val Thr Ile Ile His Pro Gly Lys Gly Ser Lys 
145                 150                 155                 160 


Glu Gly Leu His Arg Glu Gly Arg Ile Glu Thr Ile Pro Thr Ala Asp 
                165                 170                 175     


Ala Phe Met Asp Leu Ile Arg Asn Met Phe Pro Pro Asn Leu Val Glu 
            180                 185                 190         


Ala Cys Phe Lys Gln Phe Lys Thr Gln Tyr Ser Thr Arg Val Val Thr 
        195                 200                 205             


Arg Thr Met Val Arg Thr Glu Asn Gly Ser Glu Pro Gly Ala Ser Met 
    210                 215                 220                 


Pro Pro Pro Phe Ser Val Glu Asn Gly Thr Ser Phe Leu Glu Asn Val 
225                 230                 235                 240 


Thr Arg Ala Leu Gly Thr Leu Gln Glu Met Leu Ser Phe Glu Glu Thr 
                245                 250                 255     


Val Pro Val Pro Gly Ser Ala Asn Gly Ile Asn Ala Leu Gly Leu Val 
            260                 265                 270         


Val Phe Ser Val Ala Phe Gly Leu Val Ile Gly Gly Met Lys His Lys 
        275                 280                 285             


Gly Arg Val Leu Arg Asp Phe Phe Asp Ser Leu Asn Glu Ala Ile Met 
    290                 295                 300                 


Arg Leu Val Gly Ile Ile Ile Trp Tyr Ala Pro Val Gly Ile Leu Phe 
305                 310                 315                 320 


Leu Ile Ala Gly Lys Ile Leu Glu Met Glu Asp Met Ala Val Leu Gly 
                325                 330                 335     


Gly Gln Leu Gly Met Tyr Thr Leu Thr Val Ile Val Gly Leu Phe Leu 
            340                 345                 350         


His Ala Gly Ile Val Leu Pro Leu Ile Tyr Phe Leu Val Thr His Arg 
        355                 360                 365             


Asn Pro Phe Pro Phe Ile Gly Gly Met Leu Gln Ala Leu Ile Thr Ala 
    370                 375                 380                 


Met Gly Thr Ser Ser Ser Ser Ala Thr Leu Pro Ile Thr Phe Arg Cys 
385                 390                 395                 400 


Leu Glu Glu Gly Leu Gly Val Asp Arg Arg Ile Thr Arg Phe Val Leu 
                405                 410                 415     


Pro Val Gly Ala Thr Val Asn Met Asp Gly Thr Ala Leu Tyr Glu Ala 
            420                 425                 430         


Leu Ala Ala Ile Phe Ile Ala Gln Val Asn Asn Tyr Glu Leu Asn Leu 
        435                 440                 445             


Gly Gln Ile Thr Thr Ile Ser Ile Thr Ala Thr Ala Ala Ser Val Gly 
    450                 455                 460                 


Ala Ala Gly Ile Pro Gln Ala Gly Leu Val Thr Met Val Ile Val Leu 
465                 470                 475                 480 


Thr Ser Val Gly Leu Pro Thr Glu Asp Ile Thr Leu Ile Ile Ala Val 
                485                 490                 495     


Asp Trp Phe Leu Asp Arg Leu Arg Thr Met Thr Asn Val Leu Gly Asp 
            500                 505                 510         


Ser Ile Gly Ala Ala Val Ile Glu His Leu Ser Gln Arg Glu Leu Glu 
        515                 520                 525             


Leu Gln Glu Ala Glu Leu Thr Leu Pro Ser Leu Gly Lys Pro Tyr Lys 
    530                 535                 540                 


Ser Leu Met Ala Gln Glu Lys Gly Ala Ser Arg Gly Arg Gly Gly Asn 
545                 550                 555                 560 


Glu Ser Ala Met 
                


<210> 24
<211> 560
<212> PRT
<213> Homo sapiens

<400> 24
Met Val Pro His Ala Ile Leu Ala Arg Gly Arg Asp Val Cys Arg Arg 
1               5                   10                  15      


Asn Gly Leu Leu Ile Leu Ser Val Leu Ser Val Ile Val Gly Cys Leu 
            20                  25                  30          


Leu Gly Phe Phe Leu Arg Thr Arg Arg Leu Ser Pro Gln Glu Ile Ser 
        35                  40                  45              


Tyr Phe Gln Phe Pro Gly Glu Leu Leu Met Arg Met Leu Lys Met Met 
    50                  55                  60                  


Ile Leu Pro Leu Val Val Ser Ser Leu Met Ser Gly Leu Ala Ser Leu 
65                  70                  75                  80  


Asp Ala Lys Thr Ser Ser Arg Leu Gly Val Leu Thr Val Ala Tyr Tyr 
                85                  90                  95      


Leu Trp Thr Thr Phe Met Ala Val Ile Val Gly Ile Phe Met Val Ser 
            100                 105                 110         


Ile Ile His Pro Gly Ser Ala Ala Gln Lys Glu Thr Thr Glu Gln Ser 
        115                 120                 125             


Gly Lys Pro Ile Met Ser Ser Ala Asp Ala Leu Leu Asp Leu Ile Arg 
    130                 135                 140                 


Asn Met Phe Pro Ala Asn Leu Val Glu Ala Thr Phe Lys Gln Tyr Arg 
145                 150                 155                 160 


Thr Lys Thr Thr Pro Val Val Lys Ser Pro Lys Val Ala Pro Glu Glu 
                165                 170                 175     


Ala Pro Pro Arg Arg Ile Leu Ile Tyr Gly Val Gln Glu Glu Asn Gly 
            180                 185                 190         


Ser His Val Gln Asn Phe Ala Leu Asp Leu Thr Pro Pro Pro Glu Val 
        195                 200                 205             


Val Tyr Lys Ser Glu Pro Gly Thr Ser Asp Gly Met Asn Val Leu Gly 
    210                 215                 220                 


Ile Val Phe Phe Ser Ala Thr Met Gly Ile Met Leu Gly Arg Met Gly 
225                 230                 235                 240 


Asp Ser Gly Ala Pro Leu Val Ser Phe Cys Gln Cys Leu Asn Glu Ser 
                245                 250                 255     


Val Met Lys Ile Val Ala Val Ala Val Trp Tyr Phe Pro Phe Gly Ile 
            260                 265                 270         


Val Phe Leu Ile Ala Gly Lys Ile Leu Glu Met Asp Asp Pro Arg Ala 
        275                 280                 285             


Val Gly Lys Lys Leu Gly Phe Tyr Ser Val Thr Val Val Cys Gly Leu 
    290                 295                 300                 


Val Leu His Gly Leu Phe Ile Leu Pro Leu Leu Tyr Phe Phe Ile Thr 
305                 310                 315                 320 


Lys Lys Asn Pro Ile Val Phe Ile Arg Gly Ile Leu Gln Ala Leu Leu 
                325                 330                 335     


Ile Ala Leu Ala Thr Ser Ser Ser Ser Ala Thr Leu Pro Ile Thr Phe 
            340                 345                 350         


Lys Cys Leu Leu Glu Asn Asn His Ile Asp Arg Arg Ile Ala Arg Phe 
        355                 360                 365             


Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp Gly Thr Ala Leu Tyr 
    370                 375                 380                 


Glu Ala Val Ala Ala Ile Phe Ile Ala Gln Val Asn Asn Tyr Glu Leu 
385                 390                 395                 400 


Asp Phe Gly Gln Ile Ile Thr Ile Ser Ile Thr Ala Thr Ala Ala Ser 
                405                 410                 415     


Ile Gly Ala Ala Gly Ile Pro Gln Ala Gly Leu Val Thr Met Val Ile 
            420                 425                 430         


Val Leu Thr Ser Val Gly Leu Pro Thr Asp Asp Ile Thr Leu Ile Ile 
        435                 440                 445             


Ala Val Asp Trp Ala Leu Asp Arg Phe Arg Thr Met Ile Asn Val Leu 
    450                 455                 460                 


Gly Asp Ala Leu Ala Ala Gly Ile Met Ala His Ile Cys Arg Lys Asp 
465                 470                 475                 480 


Phe Ala Arg Asp Thr Gly Thr Glu Lys Leu Leu Pro Cys Glu Thr Lys 
                485                 490                 495     


Pro Val Ser Leu Gln Glu Ile Val Ala Ala Gln Gln Asn Gly Cys Val 
            500                 505                 510         


Lys Ser Val Ala Glu Ala Ser Glu Leu Thr Leu Gly Pro Thr Cys Pro 
        515                 520                 525             


His His Val Pro Val Gln Val Glu Gln Asp Glu Glu Leu Pro Ala Ala 
    530                 535                 540                 


Ser Leu Asn His Cys Thr Ile Gln Ile Ser Glu Leu Glu Thr Asn Val 
545                 550                 555                 560 


<210> 25
<211> 630
<212> PRT
<213> Homo sapiens

<400> 25
Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Glu Leu Gly Ser His Cys Val Ala Gln Thr Gly 
        35                  40                  45              


Leu Glu Leu Leu Ala Ser Gly Asp Pro Leu Pro Ser Ala Ser Gln Asn 
    50                  55                  60                  


Ala Glu Met Ile Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly Leu 
65                  70                  75                  80  


Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn Ala 
                85                  90                  95      


Glu Val Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu 
            100                 105                 110         


Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala 
        115                 120                 125             


Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val 
    130                 135                 140                 


Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys 
145                 150                 155                 160 


Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro 
                165                 170                 175     


Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly 
            180                 185                 190         


Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro 
        195                 200                 205             


Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu 
    210                 215                 220                 


Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn 
225                 230                 235                 240 


Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val 
                245                 250                 255     


Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val 
            260                 265                 270         


Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu 
        275                 280                 285             


Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val 
    290                 295                 300                 


Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser 
305                 310                 315                 320 


Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe 
                325                 330                 335     


Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn 
            340                 345                 350         


Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys 
        355                 360                 365             


Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp 
    370                 375                 380                 


Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu 
385                 390                 395                 400 


Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys 
                405                 410                 415     


Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser 
            420                 425                 430         


Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln 
        435                 440                 445             


Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro 
    450                 455                 460                 


Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro 
465                 470                 475                 480 


Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe 
                485                 490                 495     


Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln 
            500                 505                 510         


Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp 
        515                 520                 525             


Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala Phe 
    530                 535                 540                 


Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn 
545                 550                 555                 560 


Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala 
                565                 570                 575     


Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys 
            580                 585                 590         


Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro 
        595                 600                 605             


Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu 
    610                 615                 620                 


Arg Phe Pro Tyr Ala Ala 
625                 630 


<210> 26
<211> 504
<212> PRT
<213> Homo sapiens

<400> 26
Met Glu Ala Pro Leu Gln Thr Glu Met Val Glu Leu Val Pro Asn Gly 
1               5                   10                  15      


Lys His Ser Glu Gly Leu Leu Pro Val Ile Thr Pro Met Ala Gly Asn 
            20                  25                  30          


Gln Arg Val Glu Asp Pro Ala Arg Ser Cys Met Glu Gly Lys Ser Phe 
        35                  40                  45              


Leu Gln Lys Ser Pro Ser Lys Glu Pro His Phe Thr Asp Phe Glu Gly 
    50                  55                  60                  


Lys Thr Ser Phe Gly Met Ser Val Phe Asn Leu Ser Asn Ala Ile Met 
65                  70                  75                  80  


Gly Ser Gly Ile Leu Gly Leu Ala Tyr Ala Met Ala Asn Thr Gly Ile 
                85                  90                  95      


Ile Leu Phe Leu Phe Leu Leu Thr Ala Val Ala Leu Leu Ser Ser Tyr 
            100                 105                 110         


Ser Ile His Leu Leu Leu Lys Ser Ser Gly Val Val Gly Ile Arg Ala 
        115                 120                 125             


Tyr Glu Gln Leu Gly Tyr Arg Ala Phe Gly Thr Pro Gly Lys Leu Ala 
    130                 135                 140                 


Ala Ala Leu Ala Ile Thr Leu Gln Asn Ile Gly Ala Met Ser Ser Tyr 
145                 150                 155                 160 


Leu Tyr Ile Ile Lys Ser Glu Leu Pro Leu Val Ile Gln Thr Phe Leu 
                165                 170                 175     


Asn Leu Glu Glu Lys Thr Ser Asp Trp Tyr Met Asn Gly Asn Tyr Leu 
            180                 185                 190         


Val Ile Leu Val Ser Val Thr Ile Ile Leu Pro Leu Ala Leu Met Arg 
        195                 200                 205             


Gln Leu Gly Tyr Leu Gly Tyr Ser Ser Gly Phe Ser Leu Ser Cys Met 
    210                 215                 220                 


Val Phe Phe Leu Ile Ala Val Ile Tyr Lys Lys Phe His Val Pro Cys 
225                 230                 235                 240 


Pro Leu Pro Pro Asn Phe Asn Asn Thr Thr Gly Asn Phe Ser His Val 
                245                 250                 255     


Glu Ile Val Lys Glu Lys Val Gln Leu Gln Val Glu Pro Glu Ala Ser 
            260                 265                 270         


Ala Phe Cys Thr Pro Ser Tyr Phe Thr Leu Asn Ser Gln Thr Ala Tyr 
        275                 280                 285             


Thr Ile Pro Ile Met Ala Phe Ala Phe Val Cys His Pro Glu Val Leu 
    290                 295                 300                 


Pro Ile Tyr Thr Glu Leu Lys Asp Pro Ser Lys Lys Lys Met Gln His 
305                 310                 315                 320 


Ile Ser Asn Leu Ser Ile Ala Val Met Tyr Ile Met Tyr Phe Leu Ala 
                325                 330                 335     


Ala Leu Phe Gly Tyr Leu Thr Phe Tyr Asn Gly Val Glu Ser Glu Leu 
            340                 345                 350         


Leu His Thr Tyr Ser Lys Val Asp Pro Phe Asp Val Leu Ile Leu Cys 
        355                 360                 365             


Val Arg Val Ala Val Leu Thr Ala Val Thr Leu Thr Val Pro Ile Val 
    370                 375                 380                 


Leu Phe Pro Val Arg Arg Ala Ile Gln Gln Met Leu Phe Pro Asn Gln 
385                 390                 395                 400 


Glu Phe Ser Trp Leu Arg His Val Leu Ile Ala Val Gly Leu Leu Thr 
                405                 410                 415     


Cys Ile Asn Leu Leu Val Ile Phe Ala Pro Asn Ile Leu Gly Ile Phe 
            420                 425                 430         


Gly Val Ile Gly Ala Thr Ser Ala Pro Phe Leu Ile Phe Ile Phe Pro 
        435                 440                 445             


Ala Ile Phe Tyr Phe Arg Ile Met Pro Thr Glu Lys Glu Pro Ala Arg 
    450                 455                 460                 


Ser Thr Pro Lys Ile Leu Ala Leu Cys Phe Ala Met Leu Gly Phe Leu 
465                 470                 475                 480 


Leu Met Thr Met Ser Leu Ser Phe Ile Ile Ile Asp Trp Ala Ser Gly 
                485                 490                 495     


Thr Ser Arg His Gly Gly Asn His 
            500                 


<210> 27
<211> 472
<212> PRT
<213> Homo sapiens

<400> 27
Met Glu Leu Gln Asp Pro Lys Met Asn Gly Ala Leu Pro Ser Asp Ala 
1               5                   10                  15      


Val Gly Tyr Arg Gln Glu Arg Glu Gly Phe Leu Pro Ser Arg Gly Pro 
            20                  25                  30          


Ala Pro Gly Ser Lys Pro Val Gln Phe Met Asp Phe Glu Gly Lys Thr 
        35                  40                  45              


Ser Phe Gly Met Ser Val Phe Asn Leu Ser Asn Ala Ile Met Gly Ser 
    50                  55                  60                  


Gly Ile Leu Gly Leu Ala Tyr Ala Met Ala His Thr Gly Val Ile Phe 
65                  70                  75                  80  


Phe Leu Ala Leu Leu Leu Cys Ile Ala Leu Leu Ser Ser Tyr Ser Ile 
                85                  90                  95      


His Leu Leu Leu Thr Cys Ala Gly Ile Ala Gly Ile Arg Ala Tyr Glu 
            100                 105                 110         


Gln Leu Gly Gln Arg Ala Phe Gly Pro Ala Gly Lys Val Val Val Ala 
        115                 120                 125             


Thr Val Ile Cys Leu His Asn Val Gly Ala Met Ser Ser Tyr Leu Phe 
    130                 135                 140                 


Ile Ile Lys Ser Glu Leu Pro Leu Val Ile Gly Thr Phe Leu Tyr Met 
145                 150                 155                 160 


Asp Pro Glu Gly Asp Trp Phe Leu Lys Gly Asn Leu Leu Ile Ile Ile 
                165                 170                 175     


Val Ser Val Leu Ile Ile Leu Pro Leu Ala Leu Met Lys His Leu Gly 
            180                 185                 190         


Tyr Leu Gly Tyr Thr Ser Gly Leu Ser Leu Thr Cys Met Leu Phe Phe 
        195                 200                 205             


Leu Val Ser Val Ile Tyr Lys Lys Phe Gln Leu Gly Cys Ala Ile Gly 
    210                 215                 220                 


His Asn Glu Thr Ala Met Glu Ser Glu Ala Leu Val Gly Leu Pro Ser 
225                 230                 235                 240 


Gln Gly Leu Asn Ser Ser Cys Glu Ala Gln Met Phe Thr Val Asp Ser 
                245                 250                 255     


Gln Met Ser Tyr Thr Val Pro Ile Met Ala Phe Ala Phe Val Cys His 
            260                 265                 270         


Pro Glu Val Leu Pro Ile Tyr Thr Glu Leu Cys Arg Pro Ser Lys Arg 
        275                 280                 285             


Arg Met Gln Ala Val Ala Asn Val Ser Ile Gly Ala Met Phe Cys Met 
    290                 295                 300                 


Tyr Gly Leu Thr Ala Thr Phe Gly Tyr Leu Thr Phe Tyr Ser Ser Val 
305                 310                 315                 320 


Lys Ala Glu Met Leu His Met Tyr Ser Gln Lys Asp Pro Leu Ile Leu 
                325                 330                 335     


Cys Val Arg Leu Ala Val Leu Leu Ala Val Thr Leu Thr Val Pro Val 
            340                 345                 350         


Val Leu Phe Pro Ile Arg Arg Ala Leu Gln Gln Leu Leu Phe Pro Gly 
        355                 360                 365             


Lys Ala Phe Ser Trp Pro Arg His Val Ala Ile Ala Leu Ile Leu Leu 
    370                 375                 380                 


Val Leu Val Asn Val Leu Val Ile Cys Val Pro Thr Ile Arg Asp Ile 
385                 390                 395                 400 


Phe Gly Val Ile Gly Ser Thr Ser Ala Pro Ser Leu Ile Phe Ile Leu 
                405                 410                 415     


Pro Ser Ile Phe Tyr Leu Arg Ile Val Pro Ser Glu Val Glu Pro Phe 
            420                 425                 430         


Leu Ser Trp Pro Lys Ile Gln Ala Leu Cys Phe Gly Val Leu Gly Val 
        435                 440                 445             


Leu Phe Met Ala Val Ser Leu Gly Phe Met Phe Ala Asn Trp Ala Thr 
    450                 455                 460                 


Gly Gln Ser Arg Met Ser Gly His 
465                 470         


<210> 28
<211> 523
<212> PRT
<213> Homo sapiens

<400> 28
Met Ala Gly His Thr Gln Gln Pro Ser Gly Arg Gly Asn Pro Arg Pro 
1               5                   10                  15      


Ala Pro Ser Pro Ser Pro Val Pro Gly Thr Val Pro Gly Ala Ser Glu 
            20                  25                  30          


Arg Val Ala Leu Lys Lys Glu Ile Gly Leu Leu Ser Ala Cys Thr Ile 
        35                  40                  45              


Ile Ile Gly Asn Ile Ile Gly Ser Gly Ile Phe Ile Ser Pro Lys Gly 
    50                  55                  60                  


Val Leu Glu His Ser Gly Ser Val Gly Leu Ala Leu Phe Val Trp Val 
65                  70                  75                  80  


Leu Gly Gly Gly Val Thr Ala Leu Gly Ser Leu Cys Tyr Ala Glu Leu 
                85                  90                  95      


Gly Val Ala Ile Pro Lys Ser Gly Gly Asp Tyr Ala Tyr Val Thr Glu 
            100                 105                 110         


Ile Phe Gly Gly Leu Ala Gly Phe Leu Leu Leu Trp Ser Ala Val Leu 
        115                 120                 125             


Ile Met Tyr Pro Thr Ser Leu Ala Val Ile Ser Met Thr Phe Ser Asn 
    130                 135                 140                 


Tyr Val Leu Gln Pro Val Phe Pro Asn Cys Ile Pro Pro Thr Thr Ala 
145                 150                 155                 160 


Ser Arg Val Leu Ser Met Ala Cys Leu Met Leu Leu Thr Trp Val Asn 
                165                 170                 175     


Ser Ser Ser Val Arg Trp Ala Thr Arg Ile Gln Asp Met Phe Thr Gly 
            180                 185                 190         


Gly Lys Leu Leu Ala Leu Ser Leu Ile Ile Gly Val Gly Leu Leu Gln 
        195                 200                 205             


Ile Phe Gln Gly His Phe Glu Glu Leu Arg Pro Ser Asn Ala Phe Ala 
    210                 215                 220                 


Phe Trp Met Thr Pro Ser Val Gly His Leu Ala Leu Ala Phe Leu Gln 
225                 230                 235                 240 


Gly Ser Phe Ala Phe Ser Gly Trp Asn Phe Leu Asn Tyr Val Thr Glu 
                245                 250                 255     


Glu Met Val Asp Ala Arg Lys Asn Leu Pro Arg Ala Ile Phe Ile Ser 
            260                 265                 270         


Ile Pro Leu Val Thr Phe Val Tyr Thr Phe Thr Asn Ile Ala Tyr Phe 
        275                 280                 285             


Thr Ala Met Ser Pro Gln Glu Leu Leu Ser Ser Asn Ala Val Ala Val 
    290                 295                 300                 


Thr Phe Gly Glu Lys Leu Leu Gly Tyr Phe Ser Trp Val Met Pro Val 
305                 310                 315                 320 


Ser Val Ala Leu Ser Thr Phe Gly Gly Ile Asn Gly Tyr Leu Phe Thr 
                325                 330                 335     


Tyr Ser Arg Leu Cys Phe Ser Gly Ala Arg Glu Gly His Leu Pro Ser 
            340                 345                 350         


Leu Leu Ala Met Ile His Val Arg His Cys Thr Pro Ile Pro Ala Leu 
        355                 360                 365             


Leu Val Cys Cys Gly Ala Thr Ala Val Ile Met Leu Val Gly Asp Thr 
    370                 375                 380                 


Tyr Thr Leu Ile Asn Tyr Val Ser Phe Ile Asn Tyr Leu Cys Tyr Gly 
385                 390                 395                 400 


Val Thr Ile Leu Gly Leu Leu Leu Leu Arg Trp Arg Arg Pro Ala Leu 
                405                 410                 415     


His Arg Pro Ile Lys Val Asn Leu Leu Ile Pro Val Ala Tyr Leu Val 
            420                 425                 430         


Phe Trp Ala Phe Leu Leu Val Phe Ser Phe Ile Ser Glu Pro Met Val 
        435                 440                 445             


Cys Gly Val Gly Val Ile Ile Ile Leu Thr Gly Val Pro Ile Phe Phe 
    450                 455                 460                 


Leu Gly Val Phe Trp Arg Ser Lys Pro Lys Cys Val His Arg Leu Thr 
465                 470                 475                 480 


Glu Ser Met Thr His Trp Gly Gln Glu Leu Cys Phe Val Val Tyr Pro 
                485                 490                 495     


Gln Asp Ala Pro Glu Glu Glu Glu Asn Gly Pro Cys Pro Pro Ser Leu 
            500                 505                 510         


Leu Pro Ala Thr Asp Lys Pro Ser Lys Pro Gln 
        515                 520             


<210> 29
<211> 487
<212> PRT
<213> Homo sapiens

<400> 29
Met Gly Asp Thr Gly Leu Arg Lys Arg Arg Glu Asp Glu Lys Ser Ile 
1               5                   10                  15      


Gln Ser Gln Glu Pro Lys Thr Thr Ser Leu Gln Lys Glu Leu Gly Leu 
            20                  25                  30          


Ile Ser Gly Ile Ser Ile Ile Val Gly Thr Ile Ile Gly Ser Gly Ile 
        35                  40                  45              


Phe Val Ser Pro Lys Ser Val Leu Ser Asn Thr Glu Ala Val Gly Pro 
    50                  55                  60                  


Cys Leu Ile Ile Trp Ala Ala Cys Gly Val Leu Ala Thr Leu Gly Ala 
65                  70                  75                  80  


Leu Cys Phe Ala Glu Leu Gly Thr Met Ile Thr Lys Ser Gly Gly Glu 
                85                  90                  95      


Tyr Pro Tyr Leu Met Glu Ala Tyr Gly Pro Ile Pro Ala Tyr Leu Phe 
            100                 105                 110         


Ser Trp Ala Ser Leu Ile Val Ile Lys Pro Thr Ser Phe Ala Ile Ile 
        115                 120                 125             


Cys Leu Ser Phe Ser Glu Tyr Val Cys Ala Pro Phe Tyr Val Gly Cys 
    130                 135                 140                 


Lys Pro Pro Gln Ile Val Val Lys Cys Leu Ala Ala Ala Ala Ile Leu 
145                 150                 155                 160 


Phe Ile Ser Thr Val Asn Ser Leu Ser Val Arg Leu Gly Ser Tyr Val 
                165                 170                 175     


Gln Asn Ile Phe Thr Ala Ala Lys Leu Val Ile Val Ala Ile Ile Ile 
            180                 185                 190         


Ile Ser Gly Leu Val Leu Leu Ala Gln Gly Asn Thr Lys Asn Phe Asp 
        195                 200                 205             


Asn Ser Phe Glu Gly Ala Gln Leu Ser Val Gly Ala Ile Ser Leu Ala 
    210                 215                 220                 


Phe Tyr Asn Gly Leu Trp Ala Tyr Asp Gly Trp Asn Gln Leu Asn Tyr 
225                 230                 235                 240 


Ile Thr Glu Glu Leu Arg Asn Pro Tyr Arg Asn Leu Pro Leu Ala Ile 
                245                 250                 255     


Ile Ile Gly Ile Pro Leu Val Thr Ala Cys Tyr Ile Leu Met Asn Val 
            260                 265                 270         


Ser Tyr Phe Thr Val Met Thr Ala Thr Glu Leu Leu Gln Ser Gln Ala 
        275                 280                 285             


Val Ala Val Thr Phe Gly Asp Arg Val Leu Tyr Pro Ala Ser Trp Ile 
    290                 295                 300                 


Val Pro Leu Phe Val Ala Phe Ser Thr Ile Gly Ala Ala Asn Gly Thr 
305                 310                 315                 320 


Cys Phe Thr Ala Gly Arg Leu Ile Tyr Val Ala Gly Arg Glu Gly His 
                325                 330                 335     


Met Leu Lys Val Leu Ser Tyr Ile Ser Val Arg Arg Leu Thr Pro Ala 
            340                 345                 350         


Pro Ala Ile Ile Phe Tyr Gly Ile Ile Ala Thr Ile Tyr Ile Ile Pro 
        355                 360                 365             


Gly Asp Ile Asn Ser Leu Val Asn Tyr Phe Ser Phe Ala Ala Trp Leu 
    370                 375                 380                 


Phe Tyr Gly Leu Thr Ile Leu Gly Leu Ile Val Met Arg Phe Thr Arg 
385                 390                 395                 400 


Lys Glu Leu Glu Arg Pro Ile Lys Val Pro Val Val Ile Pro Val Leu 
                405                 410                 415     


Met Thr Leu Ile Ser Val Phe Leu Val Leu Ala Pro Ile Ile Ser Lys 
            420                 425                 430         


Pro Thr Trp Glu Tyr Leu Tyr Cys Val Leu Phe Ile Leu Ser Gly Leu 
        435                 440                 445             


Leu Phe Tyr Phe Leu Phe Val His Tyr Lys Phe Gly Trp Ala Gln Lys 
    450                 455                 460                 


Ile Ser Lys Pro Ile Thr Met His Leu Gln Met Leu Met Glu Val Val 
465                 470                 475                 480 


Pro Pro Glu Glu Asp Pro Glu 
                485         


<210> 30
<211> 685
<212> PRT
<213> Homo sapiens

<400> 30
Met Ala Glu Asp Lys Ser Lys Arg Asp Ser Ile Glu Met Ser Met Lys 
1               5                   10                  15      


Gly Cys Gln Thr Asn Asn Gly Phe Val His Asn Glu Asp Ile Leu Glu 
            20                  25                  30          


Gln Thr Pro Asp Pro Gly Ser Ser Thr Asp Asn Leu Lys His Ser Thr 
        35                  40                  45              


Arg Gly Ile Leu Gly Ser Gln Glu Pro Asp Phe Lys Gly Val Gln Pro 
    50                  55                  60                  


Tyr Ala Gly Met Pro Lys Glu Val Leu Phe Gln Phe Ser Gly Gln Ala 
65                  70                  75                  80  


Arg Tyr Arg Ile Pro Arg Glu Ile Leu Phe Trp Leu Thr Val Ala Ser 
                85                  90                  95      


Val Leu Val Leu Ile Ala Ala Thr Ile Ala Ile Ile Ala Leu Ser Pro 
            100                 105                 110         


Lys Cys Leu Asp Trp Trp Gln Glu Gly Pro Met Tyr Gln Ile Tyr Pro 
        115                 120                 125             


Arg Ser Phe Lys Asp Ser Asn Lys Asp Gly Asn Gly Asp Leu Lys Gly 
    130                 135                 140                 


Ile Gln Asp Lys Leu Asp Tyr Ile Thr Ala Leu Asn Ile Lys Thr Val 
145                 150                 155                 160 


Trp Ile Thr Ser Phe Tyr Lys Ser Ser Leu Lys Asp Phe Arg Tyr Gly 
                165                 170                 175     


Val Glu Asp Phe Arg Glu Val Asp Pro Ile Phe Gly Thr Met Glu Asp 
            180                 185                 190         


Phe Glu Asn Leu Val Ala Ala Ile His Asp Lys Gly Leu Lys Leu Ile 
        195                 200                 205             


Ile Asp Phe Ile Pro Asn His Thr Ser Asp Lys His Ile Trp Phe Gln 
    210                 215                 220                 


Leu Ser Arg Thr Arg Thr Gly Lys Tyr Thr Asp Tyr Tyr Ile Trp His 
225                 230                 235                 240 


Asp Cys Thr His Glu Asn Gly Lys Thr Ile Pro Pro Asn Asn Trp Leu 
                245                 250                 255     


Ser Val Tyr Gly Asn Ser Ser Trp His Phe Asp Glu Val Arg Asn Gln 
            260                 265                 270         


Cys Tyr Phe His Gln Phe Met Lys Glu Gln Pro Asp Leu Asn Phe Arg 
        275                 280                 285             


Asn Pro Asp Val Gln Glu Glu Ile Lys Glu Ile Leu Arg Phe Trp Leu 
    290                 295                 300                 


Thr Lys Gly Val Asp Gly Phe Ser Leu Asp Ala Val Lys Phe Leu Leu 
305                 310                 315                 320 


Glu Ala Lys His Leu Arg Asp Glu Ile Gln Val Asn Lys Thr Gln Ile 
                325                 330                 335     


Pro Asp Thr Val Thr Gln Tyr Ser Glu Leu Tyr His Asp Phe Thr Thr 
            340                 345                 350         


Thr Gln Val Gly Met His Asp Ile Val Arg Ser Phe Arg Gln Thr Met 
        355                 360                 365             


Asp Gln Tyr Ser Thr Glu Pro Gly Arg Tyr Arg Phe Met Gly Thr Glu 
    370                 375                 380                 


Ala Tyr Ala Glu Ser Ile Asp Arg Thr Val Met Tyr Tyr Gly Leu Pro 
385                 390                 395                 400 


Phe Ile Gln Glu Ala Asp Phe Pro Phe Asn Asn Tyr Leu Ser Met Leu 
                405                 410                 415     


Asp Thr Val Ser Gly Asn Ser Val Tyr Glu Val Ile Thr Ser Trp Met 
            420                 425                 430         


Glu Asn Met Pro Glu Gly Lys Trp Pro Asn Trp Met Ile Gly Gly Pro 
        435                 440                 445             


Asp Ser Ser Arg Leu Thr Ser Arg Leu Gly Asn Gln Tyr Val Asn Val 
    450                 455                 460                 


Met Asn Met Leu Leu Phe Thr Leu Pro Gly Thr Pro Ile Thr Tyr Tyr 
465                 470                 475                 480 


Gly Glu Glu Ile Gly Met Gly Asn Ile Val Ala Ala Asn Leu Asn Glu 
                485                 490                 495     


Ser Tyr Asp Ile Asn Thr Leu Arg Ser Lys Ser Pro Met Gln Trp Asp 
            500                 505                 510         


Asn Ser Ser Asn Ala Gly Phe Ser Glu Ala Ser Asn Thr Trp Leu Pro 
        515                 520                 525             


Thr Asn Ser Asp Tyr His Thr Val Asn Val Asp Val Gln Lys Thr Gln 
    530                 535                 540                 


Pro Arg Ser Ala Leu Lys Leu Tyr Gln Asp Leu Ser Leu Leu His Ala 
545                 550                 555                 560 


Asn Glu Leu Leu Leu Asn Arg Gly Trp Phe Cys His Leu Arg Asn Asp 
                565                 570                 575     


Ser His Tyr Val Val Tyr Thr Arg Glu Leu Asp Gly Ile Asp Arg Ile 
            580                 585                 590         


Phe Ile Val Val Leu Asn Phe Gly Glu Ser Thr Leu Leu Asn Leu His 
        595                 600                 605             


Asn Met Ile Ser Gly Leu Pro Ala Lys Met Arg Ile Arg Leu Ser Thr 
    610                 615                 620                 


Asn Ser Ala Asp Lys Gly Ser Lys Val Asp Thr Ser Gly Ile Phe Leu 
625                 630                 635                 640 


Asp Lys Gly Glu Gly Leu Ile Phe Glu His Asn Thr Lys Asn Leu Leu 
                645                 650                 655     


His Arg Gln Thr Ala Phe Arg Asp Arg Cys Phe Val Ser Asn Arg Ala 
            660                 665                 670         


Cys Tyr Ser Ser Val Leu Asn Ile Leu Tyr Thr Ser Cys 
        675                 680                 685 


<210> 31
<211> 476
<212> PRT
<213> Homo sapiens

<400> 31
Met Ser Thr Gln Arg Leu Arg Asn Glu Asp Tyr His Asp Tyr Ser Ser 
1               5                   10                  15      


Thr Asp Val Ser Pro Glu Glu Ser Pro Ser Glu Gly Leu Asn Asn Leu 
            20                  25                  30          


Ser Ser Pro Gly Ser Tyr Gln Arg Phe Gly Gln Ser Asn Ser Thr Thr 
        35                  40                  45              


Trp Phe Gln Thr Leu Ile His Leu Leu Lys Gly Asn Ile Gly Thr Gly 
    50                  55                  60                  


Leu Leu Gly Leu Pro Leu Ala Val Lys Asn Ala Gly Ile Val Met Gly 
65                  70                  75                  80  


Pro Ile Ser Leu Leu Ile Ile Gly Ile Val Ala Val His Cys Met Gly 
                85                  90                  95      


Ile Leu Val Lys Cys Ala His His Phe Cys Arg Arg Leu Asn Lys Ser 
            100                 105                 110         


Phe Val Asp Tyr Gly Asp Thr Val Met Tyr Gly Leu Glu Ser Ser Pro 
        115                 120                 125             


Cys Ser Trp Leu Arg Asn His Ala His Trp Gly Arg Arg Val Val Asp 
    130                 135                 140                 


Phe Phe Leu Ile Val Thr Gln Leu Gly Phe Cys Cys Val Tyr Phe Val 
145                 150                 155                 160 


Phe Leu Ala Asp Asn Phe Lys Gln Val Ile Glu Ala Ala Asn Gly Thr 
                165                 170                 175     


Thr Asn Asn Cys His Asn Asn Glu Thr Val Ile Leu Thr Pro Thr Met 
            180                 185                 190         


Asp Ser Arg Leu Tyr Met Leu Ser Phe Leu Pro Phe Leu Val Leu Leu 
        195                 200                 205             


Val Phe Ile Arg Asn Leu Arg Ala Leu Ser Ile Phe Ser Leu Leu Ala 
    210                 215                 220                 


Asn Ile Thr Met Leu Val Ser Leu Val Met Ile Tyr Gln Phe Ile Val 
225                 230                 235                 240 


Gln Arg Ile Pro Asp Pro Ser His Leu Pro Leu Val Ala Pro Trp Lys 
                245                 250                 255     


Thr Tyr Pro Leu Phe Phe Gly Thr Ala Ile Phe Ser Phe Glu Gly Ile 
            260                 265                 270         


Gly Met Val Leu Pro Leu Glu Asn Lys Met Lys Asp Pro Arg Lys Phe 
        275                 280                 285             


Pro Leu Ile Leu Tyr Leu Gly Met Val Ile Val Thr Ile Leu Tyr Ile 
    290                 295                 300                 


Ser Leu Gly Cys Leu Gly Tyr Leu Gln Phe Gly Ala Asn Ile Gln Gly 
305                 310                 315                 320 


Ser Ile Thr Leu Asn Leu Pro Asn Cys Trp Leu Tyr Gln Ser Val Lys 
                325                 330                 335     


Leu Leu Tyr Ser Ile Gly Ile Phe Phe Thr Tyr Ala Leu Gln Phe Tyr 
            340                 345                 350         


Val Pro Ala Glu Ile Ile Ile Pro Phe Phe Val Ser Arg Ala Pro Glu 
        355                 360                 365             


His Cys Glu Leu Val Val Asp Leu Phe Val Arg Thr Val Leu Val Cys 
    370                 375                 380                 


Leu Thr Cys Ile Leu Ala Ile Leu Ile Pro Arg Leu Asp Leu Val Ile 
385                 390                 395                 400 


Ser Leu Val Gly Ser Val Ser Ser Ser Ala Leu Ala Leu Ile Ile Pro 
                405                 410                 415     


Pro Leu Leu Glu Val Thr Thr Phe Tyr Ser Glu Gly Met Ser Pro Leu 
            420                 425                 430         


Thr Ile Phe Lys Asp Ala Leu Ile Ser Ile Leu Gly Phe Val Gly Phe 
        435                 440                 445             


Val Val Gly Thr Tyr Glu Ala Leu Tyr Glu Leu Ile Gln Pro Ser Asn 
    450                 455                 460                 


Ala Pro Ile Phe Ile Asn Ser Thr Cys Ala Phe Ile 
465                 470                 475     


<210> 32
<211> 483
<212> PRT
<213> Homo sapiens

<400> 32
Met Ser Val Thr Lys Ser Thr Glu Gly Pro Gln Gly Ala Val Ala Ile 
1               5                   10                  15      


Lys Leu Asp Leu Met Ser Pro Pro Glu Ser Ala Lys Lys Leu Glu Asn 
            20                  25                  30          


Lys Asp Ser Thr Phe Leu Asp Glu Ser Pro Ser Glu Ser Ala Gly Leu 
        35                  40                  45              


Lys Lys Thr Lys Gly Ile Thr Val Phe Gln Ala Leu Ile His Leu Val 
    50                  55                  60                  


Lys Gly Asn Met Gly Thr Gly Ile Leu Gly Leu Pro Leu Ala Val Lys 
65                  70                  75                  80  


Asn Ala Gly Ile Leu Met Gly Pro Leu Ser Leu Leu Val Met Gly Phe 
                85                  90                  95      


Ile Ala Cys His Cys Met His Ile Leu Val Lys Cys Ala Gln Arg Phe 
            100                 105                 110         


Cys Lys Arg Leu Asn Lys Pro Phe Met Asp Tyr Gly Asp Thr Val Met 
        115                 120                 125             


His Gly Leu Glu Ala Asn Pro Asn Ala Trp Leu Gln Asn His Ala His 
    130                 135                 140                 


Trp Gly Arg His Ile Val Ser Phe Phe Leu Ile Ile Thr Gln Leu Gly 
145                 150                 155                 160 


Phe Cys Cys Val Tyr Ile Val Phe Leu Ala Asp Asn Leu Lys Gln Val 
                165                 170                 175     


Val Glu Ala Val Asn Ser Thr Thr Asn Asn Cys Tyr Ser Asn Glu Thr 
            180                 185                 190         


Val Ile Leu Thr Pro Thr Met Asp Ser Arg Leu Tyr Met Leu Ser Phe 
        195                 200                 205             


Leu Pro Phe Leu Val Leu Leu Val Leu Ile Arg Asn Leu Arg Ile Leu 
    210                 215                 220                 


Thr Ile Phe Ser Met Leu Ala Asn Ile Ser Met Leu Val Ser Leu Val 
225                 230                 235                 240 


Ile Ile Ile Gln Tyr Ile Thr Gln Glu Ile Pro Asp Pro Ser Arg Leu 
                245                 250                 255     


Pro Leu Val Ala Ser Trp Lys Thr Tyr Pro Leu Phe Phe Gly Thr Ala 
            260                 265                 270         


Ile Phe Ser Phe Glu Ser Ile Gly Val Val Leu Pro Leu Glu Asn Lys 
        275                 280                 285             


Met Lys Asn Ala Arg His Phe Pro Ala Ile Leu Ser Leu Gly Met Ser 
    290                 295                 300                 


Ile Val Thr Ser Leu Tyr Ile Gly Met Ala Ala Leu Gly Tyr Leu Arg 
305                 310                 315                 320 


Phe Gly Asp Asp Ile Lys Ala Ser Ile Ser Leu Asn Leu Pro Asn Cys 
                325                 330                 335     


Trp Leu Tyr Gln Ser Val Lys Leu Leu Tyr Ile Ala Gly Ile Leu Cys 
            340                 345                 350         


Thr Tyr Ala Leu Gln Phe Tyr Val Pro Ala Glu Ile Ile Ile Pro Phe 
        355                 360                 365             


Ala Ile Ser Arg Val Ser Thr Arg Trp Ala Leu Pro Leu Asp Leu Ser 
    370                 375                 380                 


Ile Arg Leu Val Met Val Cys Leu Thr Cys Leu Leu Ala Ile Leu Ile 
385                 390                 395                 400 


Pro Arg Leu Asp Leu Val Ile Ser Leu Val Gly Ser Val Ser Gly Thr 
                405                 410                 415     


Ala Leu Ala Leu Ile Ile Pro Pro Leu Leu Glu Val Thr Thr Phe Tyr 
            420                 425                 430         


Ser Glu Gly Met Ser Pro Leu Thr Ile Phe Lys Asp Ala Leu Ile Ser 
        435                 440                 445             


Ile Leu Gly Phe Val Gly Phe Val Val Gly Thr Tyr Gln Ala Leu Asp 
    450                 455                 460                 


Glu Leu Leu Lys Ser Glu Asp Ser His Pro Phe Ser Asn Ser Thr Thr 
465                 470                 475                 480 


Phe Val Arg 
            


<210> 33
<211> 642
<212> PRT
<213> Homo sapiens

<400> 33
Met Asp Lys Leu Lys Cys Pro Ser Phe Phe Lys Cys Arg Glu Lys Glu 
1               5                   10                  15      


Lys Val Ser Ala Ser Ser Glu Asn Phe His Val Gly Glu Asn Asp Glu 
            20                  25                  30          


Asn Gln Asp Arg Gly Asn Trp Ser Lys Lys Ser Asp Tyr Leu Leu Ser 
        35                  40                  45              


Met Ile Gly Tyr Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr 
    50                  55                  60                  


Leu Thr Tyr Ser Asn Gly Gly Gly Ala Phe Leu Ile Pro Tyr Ala Ile 
65                  70                  75                  80  


Met Leu Ala Leu Ala Gly Leu Pro Leu Phe Phe Leu Glu Cys Ser Leu 
                85                  90                  95      


Gly Gln Phe Ala Ser Leu Gly Pro Val Ser Val Trp Arg Ile Leu Pro 
            100                 105                 110         


Leu Phe Gln Gly Val Gly Ile Thr Met Val Leu Ile Ser Ile Phe Val 
        115                 120                 125             


Thr Ile Tyr Tyr Asn Val Ile Ile Ala Tyr Ser Leu Tyr Tyr Met Phe 
    130                 135                 140                 


Ala Ser Phe Gln Ser Glu Leu Pro Trp Lys Asn Cys Ser Ser Trp Ser 
145                 150                 155                 160 


Asp Lys Asn Cys Ser Arg Ser Pro Ile Val Thr His Cys Asn Val Ser 
                165                 170                 175     


Thr Val Asn Lys Gly Ile Gln Glu Ile Ile Gln Met Asn Lys Ser Trp 
            180                 185                 190         


Val Asp Ile Asn Asn Phe Thr Cys Ile Asn Gly Ser Glu Ile Tyr Gln 
        195                 200                 205             


Pro Gly Gln Leu Pro Ser Glu Gln Tyr Trp Asn Lys Val Ala Leu Gln 
    210                 215                 220                 


Arg Ser Ser Gly Met Asn Glu Thr Gly Val Ile Val Trp Tyr Leu Ala 
225                 230                 235                 240 


Leu Cys Leu Leu Leu Ala Trp Leu Ile Val Gly Ala Ala Leu Phe Lys 
                245                 250                 255     


Gly Ile Lys Ser Ser Gly Lys Val Val Tyr Phe Thr Ala Leu Phe Pro 
            260                 265                 270         


Tyr Val Val Leu Leu Ile Leu Leu Val Arg Gly Ala Thr Leu Glu Gly 
        275                 280                 285             


Ala Ser Lys Gly Ile Ser Tyr Tyr Ile Gly Ala Gln Ser Asn Phe Thr 
    290                 295                 300                 


Lys Leu Lys Glu Ala Glu Val Trp Lys Asp Ala Ala Thr Gln Ile Phe 
305                 310                 315                 320 


Tyr Ser Leu Ser Val Ala Trp Gly Gly Leu Val Ala Leu Ser Ser Tyr 
                325                 330                 335     


Asn Lys Phe Lys Asn Asn Cys Phe Ser Asp Ala Ile Val Val Cys Leu 
            340                 345                 350         


Thr Asn Cys Leu Thr Ser Val Phe Ala Gly Phe Ala Ile Phe Ser Ile 
        355                 360                 365             


Leu Gly His Met Ala His Ile Ser Gly Lys Glu Val Ser Gln Val Val 
    370                 375                 380                 


Lys Ser Gly Phe Asp Leu Ala Phe Ile Ala Tyr Pro Glu Ala Leu Ala 
385                 390                 395                 400 


Gln Leu Pro Gly Gly Pro Phe Trp Ser Ile Leu Phe Phe Phe Met Leu 
                405                 410                 415     


Leu Thr Leu Gly Leu Asp Ser Gln Phe Ala Ser Ile Glu Thr Ile Thr 
            420                 425                 430         


Thr Thr Ile Gln Asp Leu Phe Pro Lys Val Met Lys Lys Met Arg Val 
        435                 440                 445             


Pro Ile Thr Leu Gly Cys Cys Leu Val Leu Phe Leu Leu Gly Leu Val 
    450                 455                 460                 


Cys Val Thr Gln Ala Gly Ile Tyr Trp Val His Leu Ile Asp His Phe 
465                 470                 475                 480 


Cys Ala Gly Trp Gly Ile Leu Ile Ala Ala Ile Leu Glu Leu Val Gly 
                485                 490                 495     


Ile Ile Trp Ile Tyr Gly Gly Asn Arg Phe Ile Glu Asp Thr Glu Met 
            500                 505                 510         


Met Ile Gly Ala Lys Arg Trp Ile Phe Trp Leu Trp Trp Arg Ala Cys 
        515                 520                 525             


Trp Phe Val Ile Thr Pro Ile Leu Leu Ile Ala Ile Phe Ile Trp Ser 
    530                 535                 540                 


Leu Val Gln Phe His Arg Pro Asn Tyr Gly Ala Ile Pro Tyr Pro Asp 
545                 550                 555                 560 


Trp Gly Val Ala Leu Gly Trp Cys Met Ile Val Phe Cys Ile Ile Trp 
                565                 570                 575     


Ile Pro Ile Met Ala Ile Ile Lys Ile Ile Gln Ala Lys Gly Asn Ile 
            580                 585                 590         


Phe Gln Arg Leu Ile Ser Cys Cys Arg Pro Ala Ser Asn Trp Gly Pro 
        595                 600                 605             


Tyr Leu Glu Gln His Arg Gly Glu Arg Tyr Lys Asp Met Val Asp Pro 
    610                 615                 620                 


Lys Lys Glu Ala Asp His Glu Ile Pro Thr Val Ser Gly Ser Arg Lys 
625                 630                 635                 640 


Pro Glu 
        


<210> 34
<211> 511
<212> PRT
<213> Homo sapiens

<400> 34
Met Val Asp Ser Thr Glu Tyr Glu Val Ala Ser Gln Pro Glu Val Glu 
1               5                   10                  15      


Thr Ser Pro Leu Gly Asp Gly Ala Ser Pro Gly Pro Glu Gln Val Lys 
            20                  25                  30          


Leu Lys Lys Glu Ile Ser Leu Leu Asn Gly Val Cys Leu Ile Val Gly 
        35                  40                  45              


Asn Met Ile Gly Ser Gly Ile Phe Val Ser Pro Lys Gly Val Leu Ile 
    50                  55                  60                  


Tyr Ser Ala Ser Phe Gly Leu Ser Leu Val Ile Trp Ala Val Gly Gly 
65                  70                  75                  80  


Leu Phe Ser Val Phe Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr 
                85                  90                  95      


Ile Lys Lys Ser Gly Ala Ser Tyr Ala Tyr Ile Leu Glu Ala Phe Gly 
            100                 105                 110         


Gly Phe Leu Ala Phe Ile Arg Leu Trp Thr Ser Leu Leu Ile Ile Glu 
        115                 120                 125             


Pro Thr Ser Gln Ala Ile Ile Ala Ile Thr Phe Ala Asn Tyr Met Val 
    130                 135                 140                 


Gln Pro Leu Phe Pro Ser Cys Phe Ala Pro Tyr Ala Ala Ser Arg Leu 
145                 150                 155                 160 


Leu Ala Ala Ala Cys Ile Cys Leu Leu Thr Phe Ile Asn Cys Ala Tyr 
                165                 170                 175     


Val Lys Trp Gly Thr Leu Val Gln Asp Ile Phe Thr Tyr Ala Lys Val 
            180                 185                 190         


Leu Ala Leu Ile Ala Val Ile Val Ala Gly Ile Val Arg Leu Gly Gln 
        195                 200                 205             


Gly Ala Ser Thr His Phe Glu Asn Ser Phe Glu Gly Ser Ser Phe Ala 
    210                 215                 220                 


Val Gly Asp Ile Ala Leu Ala Leu Tyr Ser Ala Leu Phe Ser Tyr Ser 
225                 230                 235                 240 


Gly Trp Asp Thr Leu Asn Tyr Val Thr Glu Glu Ile Lys Asn Pro Glu 
                245                 250                 255     


Arg Asn Leu Pro Leu Ser Ile Gly Ile Ser Met Pro Ile Val Thr Ile 
            260                 265                 270         


Ile Tyr Ile Leu Thr Asn Val Ala Tyr Tyr Thr Val Leu Asp Met Arg 
        275                 280                 285             


Asp Ile Leu Ala Ser Asp Ala Val Ala Val Thr Phe Ala Asp Gln Ile 
    290                 295                 300                 


Phe Gly Ile Phe Asn Trp Ile Ile Pro Leu Ser Val Ala Leu Ser Cys 
305                 310                 315                 320 


Phe Gly Gly Leu Asn Ala Ser Ile Val Ala Ala Ser Arg Leu Phe Phe 
                325                 330                 335     


Val Gly Ser Arg Glu Gly His Leu Pro Asp Ala Ile Cys Met Ile His 
            340                 345                 350         


Val Glu Arg Phe Thr Pro Val Pro Ser Leu Leu Phe Asn Gly Ile Met 
        355                 360                 365             


Ala Leu Ile Tyr Leu Cys Val Glu Asp Ile Phe Gln Leu Ile Asn Tyr 
    370                 375                 380                 


Tyr Ser Phe Ser Tyr Trp Phe Phe Val Gly Leu Ser Ile Val Gly Gln 
385                 390                 395                 400 


Leu Tyr Leu Arg Trp Lys Glu Pro Asp Arg Pro Arg Pro Leu Lys Leu 
                405                 410                 415     


Ser Val Phe Phe Pro Ile Val Phe Cys Leu Cys Thr Ile Phe Leu Val 
            420                 425                 430         


Ala Val Pro Leu Tyr Ser Asp Thr Ile Asn Ser Leu Ile Gly Ile Ala 
        435                 440                 445             


Ile Ala Leu Ser Gly Leu Pro Phe Tyr Phe Leu Ile Ile Arg Val Pro 
    450                 455                 460                 


Glu His Lys Arg Pro Leu Tyr Leu Arg Arg Ile Val Gly Ser Ala Thr 
465                 470                 475                 480 


Arg Tyr Leu Gln Val Leu Cys Met Ser Val Ala Ala Glu Met Asp Leu 
                485                 490                 495     


Glu Asp Gly Gly Glu Met Pro Lys Gln Arg Asp Pro Lys Ser Asn 
            500                 505                 510     


<210> 35
<211> 515
<212> PRT
<213> Homo sapiens

<400> 35
Met Glu Ala Arg Glu Pro Gly Arg Pro Thr Pro Thr Tyr His Leu Val 
1               5                   10                  15      


Pro Asn Thr Ser Gln Ser Gln Val Glu Glu Asp Val Ser Ser Pro Pro 
            20                  25                  30          


Gln Arg Ser Ser Glu Thr Met Gln Leu Lys Lys Glu Ile Ser Leu Leu 
        35                  40                  45              


Asn Gly Val Ser Leu Val Val Gly Asn Met Ile Gly Ser Gly Ile Phe 
    50                  55                  60                  


Val Ser Pro Lys Gly Val Leu Val His Thr Ala Ser Tyr Gly Met Ser 
65                  70                  75                  80  


Leu Ile Val Trp Ala Ile Gly Gly Leu Phe Ser Val Val Gly Ala Leu 
                85                  90                  95      


Cys Tyr Ala Glu Leu Gly Thr Thr Ile Thr Lys Ser Gly Ala Ser Tyr 
            100                 105                 110         


Ala Tyr Ile Leu Glu Ala Phe Gly Gly Phe Ile Ala Phe Ile Arg Leu 
        115                 120                 125             


Trp Val Ser Leu Leu Val Val Glu Pro Thr Gly Gln Ala Ile Ile Ala 
    130                 135                 140                 


Ile Thr Phe Ala Asn Tyr Ile Ile Gln Pro Ser Phe Pro Ser Cys Asp 
145                 150                 155                 160 


Pro Pro Tyr Leu Ala Cys Arg Leu Leu Ala Ala Ala Cys Ile Cys Leu 
                165                 170                 175     


Leu Thr Phe Val Asn Cys Ala Tyr Val Lys Trp Gly Thr Arg Val Gln 
            180                 185                 190         


Asp Thr Phe Thr Tyr Ala Lys Val Val Ala Leu Ile Ala Ile Ile Val 
        195                 200                 205             


Met Gly Leu Val Lys Leu Cys Gln Gly His Ser Glu His Phe Gln Asp 
    210                 215                 220                 


Ala Phe Glu Gly Ser Ser Trp Asp Met Gly Asn Leu Ser Leu Ala Leu 
225                 230                 235                 240 


Tyr Ser Ala Leu Phe Ser Tyr Ser Gly Trp Asp Thr Leu Asn Phe Val 
                245                 250                 255     


Thr Glu Glu Ile Lys Asn Pro Glu Arg Asn Leu Pro Leu Ala Ile Gly 
            260                 265                 270         


Ile Ser Met Pro Ile Val Thr Leu Ile Tyr Ile Leu Thr Asn Val Ala 
        275                 280                 285             


Tyr Tyr Thr Val Leu Asn Ile Ser Asp Val Leu Ser Ser Asp Ala Val 
    290                 295                 300                 


Ala Val Thr Phe Ala Asp Gln Thr Phe Gly Met Phe Ser Trp Thr Ile 
305                 310                 315                 320 


Pro Ile Ala Val Ala Leu Ser Cys Phe Gly Gly Leu Asn Ala Ser Ile 
                325                 330                 335     


Phe Ala Ser Ser Arg Leu Phe Phe Val Gly Ser Arg Glu Gly His Leu 
            340                 345                 350         


Pro Asp Leu Leu Ser Met Ile His Ile Glu Arg Phe Thr Pro Ile Pro 
        355                 360                 365             


Ala Leu Leu Phe Asn Cys Thr Met Ala Leu Ile Tyr Leu Ile Val Glu 
    370                 375                 380                 


Asp Val Phe Gln Leu Ile Asn Tyr Phe Ser Phe Ser Tyr Trp Phe Phe 
385                 390                 395                 400 


Val Gly Leu Ser Val Val Gly Gln Leu Tyr Leu Arg Trp Lys Glu Pro 
                405                 410                 415     


Lys Arg Pro Arg Pro Leu Lys Leu Ser Val Phe Phe Pro Ile Val Phe 
            420                 425                 430         


Cys Ile Cys Ser Val Phe Leu Val Ile Val Pro Leu Phe Thr Asp Thr 
        435                 440                 445             


Ile Asn Ser Leu Ile Gly Ile Gly Ile Ala Leu Ser Gly Val Pro Phe 
    450                 455                 460                 


Tyr Phe Met Gly Val Tyr Leu Pro Glu Ser Arg Arg Pro Leu Phe Ile 
465                 470                 475                 480 


Arg Asn Val Leu Ala Ala Ile Thr Arg Gly Thr Gln Gln Leu Cys Phe 
                485                 490                 495     


Cys Val Leu Thr Glu Leu Asp Val Ala Glu Glu Lys Lys Asp Glu Arg 
            500                 505                 510         


Lys Thr Asp 
        515 


<210> 36

<400> 36
000


<210> 37
<211> 397
<212> PRT
<213> Pseudomonas putida

<400> 37
Met His Gly Ser Asn Lys Leu Pro Gly Phe Ala Thr Arg Ala Ile His 
1               5                   10                  15      


His Gly Tyr Asp Pro Gln Asp His Gly Gly Ala Leu Val Pro Pro Val 
            20                  25                  30          


Tyr Gln Thr Ala Thr Phe Thr Phe Pro Thr Val Glu Tyr Gly Ala Ala 
        35                  40                  45              


Cys Phe Ala Gly Glu Gln Ala Gly His Phe Tyr Ser Arg Ile Ser Asn 
    50                  55                  60                  


Pro Thr Leu Asn Leu Leu Glu Ala Arg Met Ala Ser Leu Glu Gly Gly 
65                  70                  75                  80  


Glu Ala Gly Leu Ala Leu Ala Ser Gly Met Gly Ala Ile Thr Ser Thr 
                85                  90                  95      


Leu Trp Thr Leu Leu Arg Pro Gly Asp Glu Val Leu Leu Gly Asn Thr 
            100                 105                 110         


Leu Tyr Gly Cys Thr Phe Ala Phe Leu His His Gly Ile Gly Glu Phe 
        115                 120                 125             


Gly Val Lys Leu Arg His Val Asp Met Ala Asp Leu Gln Ala Leu Glu 
    130                 135                 140                 


Ala Ala Met Thr Pro Ala Thr Arg Val Ile Tyr Phe Glu Ser Pro Ala 
145                 150                 155                 160 


Asn Pro Asn Met His Met Ala Asp Ile Ala Gly Val Ala Lys Ile Ala 
                165                 170                 175     


Arg Lys His Gly Ala Thr Val Val Val Asp Asn Thr Tyr Cys Thr Pro 
            180                 185                 190         


Tyr Leu Gln Arg Pro Leu Glu Leu Gly Ala Asp Leu Val Val His Ser 
        195                 200                 205             


Ala Thr Lys Tyr Leu Ser Gly His Gly Asp Ile Thr Ala Gly Ile Val 
    210                 215                 220                 


Val Gly Ser Gln Ala Leu Val Asp Arg Ile Arg Leu Gln Gly Leu Lys 
225                 230                 235                 240 


Asp Met Thr Gly Ala Val Leu Ser Pro His Asp Ala Ala Leu Leu Met 
                245                 250                 255     


Arg Gly Ile Lys Thr Leu Asn Leu Arg Met Asp Arg His Cys Ala Asn 
            260                 265                 270         


Ala Gln Val Leu Ala Glu Phe Leu Ala Arg Gln Pro Gln Val Glu Leu 
        275                 280                 285             


Ile His Tyr Pro Gly Leu Ala Ser Phe Pro Gln Tyr Thr Leu Ala Arg 
    290                 295                 300                 


Gln Gln Met Ser Gln Pro Gly Gly Met Ile Ala Phe Glu Leu Lys Gly 
305                 310                 315                 320 


Gly Ile Gly Ala Gly Arg Arg Phe Met Asn Ala Leu Gln Leu Phe Ser 
                325                 330                 335     


Arg Ala Val Ser Leu Gly Asp Ala Glu Ser Leu Ala Gln His Pro Ala 
            340                 345                 350         


Ser Met Thr His Ser Ser Tyr Thr Pro Glu Glu Arg Ala His Tyr Gly 
        355                 360                 365             


Ile Ser Glu Gly Leu Val Arg Leu Ser Val Gly Leu Glu Asp Ile Asp 
    370                 375                 380                 


Asp Leu Leu Ala Asp Val Gln Gln Ala Leu Lys Ala Ser 
385                 390                 395         


<210> 38
<211> 394
<212> PRT
<213> Fusobacterium nucleatum

<400> 38
Met Glu Met Lys Lys Ser Gly Leu Gly Thr Thr Ala Ile His Ala Gly 
1               5                   10                  15      


Thr Leu Lys Asn Leu Tyr Gly Thr Leu Ala Met Pro Ile Tyr Gln Thr 
            20                  25                  30          


Ser Thr Phe Ile Phe Asp Ser Ala Glu Gln Gly Gly Arg Arg Phe Ala 
        35                  40                  45              


Leu Glu Glu Ala Gly Tyr Ile Tyr Thr Arg Leu Gly Asn Pro Thr Thr 
    50                  55                  60                  


Thr Val Leu Glu Asn Lys Ile Ala Ala Leu Glu Glu Gly Glu Ala Gly 
65                  70                  75                  80  


Ile Ala Met Ser Ser Gly Met Gly Ala Ile Ser Ser Thr Leu Trp Thr 
                85                  90                  95      


Val Leu Lys Ala Gly Asp His Val Val Thr Asp Lys Thr Leu Tyr Gly 
            100                 105                 110         


Cys Thr Phe Ala Leu Met Asn His Gly Leu Thr Arg Phe Gly Val Glu 
        115                 120                 125             


Val Thr Phe Val Asp Thr Ser Asn Leu Glu Glu Val Lys Asn Ala Met 
    130                 135                 140                 


Lys Lys Asn Thr Arg Val Val Tyr Leu Glu Thr Pro Ala Asn Pro Asn 
145                 150                 155                 160 


Leu Lys Ile Val Asp Leu Glu Ala Leu Ser Lys Ile Ala His Thr Asn 
                165                 170                 175     


Pro Asn Thr Leu Val Ile Val Asp Asn Thr Phe Ala Thr Pro Tyr Met 
            180                 185                 190         


Gln Lys Pro Leu Lys Leu Gly Val Asp Ile Val Val His Ser Ala Thr 
        195                 200                 205             


Lys Tyr Leu Asn Gly His Gly Asp Val Ile Ala Gly Leu Val Val Thr 
    210                 215                 220                 


Arg Gln Glu Leu Ala Asp Gln Ile Arg Phe Val Gly Leu Lys Asp Met 
225                 230                 235                 240 


Thr Gly Ala Val Leu Gly Pro Gln Glu Ala Tyr Tyr Ile Ile Arg Gly 
                245                 250                 255     


Leu Lys Thr Phe Glu Ile Arg Met Glu Arg His Cys Lys Asn Ala Arg 
            260                 265                 270         


Thr Ile Val Asp Phe Leu Asn Lys His Pro Lys Val Glu Lys Val Tyr 
        275                 280                 285             


Tyr Pro Gly Leu Glu Thr His Pro Gly Tyr Glu Ile Ala Lys Lys Gln 
    290                 295                 300                 


Met Lys Asp Phe Gly Ala Met Ile Ser Phe Glu Leu Lys Gly Gly Phe 
305                 310                 315                 320 


Glu Ala Gly Lys Thr Leu Leu Asn Asn Leu Lys Leu Cys Ser Leu Ala 
                325                 330                 335     


Val Ser Leu Gly Asp Thr Glu Thr Leu Ile Gln His Pro Ala Ser Met 
            340                 345                 350         


Thr His Ser Pro Tyr Thr Lys Glu Glu Arg Glu Val Ala Gly Ile Thr 
        355                 360                 365             


Asp Gly Leu Val Arg Leu Ser Val Gly Leu Glu Asn Val Glu Asp Ile 
    370                 375                 380                 


Ile Ala Asp Leu Glu Gln Gly Leu Glu Lys 
385                 390                 


<210> 39
<211> 452
<212> PRT
<213> Streptomyces ambofaciens

<400> 39
Met Ser Gln Pro Ile Asp Ser Val Thr Ala Gly His Thr Pro Glu Gly 
1               5                   10                  15      


Ala Pro Ala Glu Pro Asp Ala Pro Gly Trp Ser Phe Glu Thr Arg Gln 
            20                  25                  30          


Leu His Ala Gly Ala Ala Pro Asp Thr Ala Thr Gly Ala Arg Ala Thr 
        35                  40                  45              


Pro Ile Tyr Gln Thr Thr Ser Phe Val Phe Gln Asp Thr Gln His Ala 
    50                  55                  60                  


Ala Asp Leu Phe Ser Leu Ala Glu Pro Gly Asn Ile Tyr Thr Arg Ile 
65                  70                  75                  80  


His Asn Pro Thr Gln Asp Val Phe Glu Gln Arg Val Ala Ser Leu Glu 
                85                  90                  95      


Gly Gly Val Ala Ala Val Ala Leu Ala Ser Gly Gln Ala Ala Glu Thr 
            100                 105                 110         


Leu Ala Val Leu Thr Leu Ala Gly Ala Gly Asp His Ile Val Ser Ser 
        115                 120                 125             


Ala Ser Leu Tyr Gly Gly Thr Tyr Asn Leu Phe Arg His Thr Leu Pro 
    130                 135                 140                 


Arg Phe Gly Ile Glu Val Ser Phe Val Asp Asp Pro Asp Asp Ile Glu 
145                 150                 155                 160 


Ala Trp Arg Ala Ala Ile Arg Pro Gly Thr Lys Ala Leu Phe Ala Glu 
                165                 170                 175     


Thr Leu Gly Asn Pro Arg Gly Asn Val Leu Asp Val Arg Ala Val Ala 
            180                 185                 190         


Asp Val Ala His Glu Ala Gly Val Pro Leu Ile Val Asp Asn Thr Val 
        195                 200                 205             


Pro Thr Pro Tyr Leu Leu Arg Pro Ile Glu His Gly Ala Asp Ile Val 
    210                 215                 220                 


Val His Ser Ala Thr Lys Phe Leu Gly Gly His Gly Thr Thr Ile Gly 
225                 230                 235                 240 


Gly Val Val Val Asp Gly Gly Thr Phe Asp Phe Gly Ala His Ala Glu 
                245                 250                 255     


Arg Phe Pro Gly Phe Thr Glu Pro Asp Pro Ser Tyr His Gly Leu Arg 
            260                 265                 270         


Tyr Trp Pro Ala Leu Gly Pro Gly Ala Phe Ala Val Lys Leu Arg Val 
        275                 280                 285             


Gln Leu Leu Arg Asp Leu Gly Pro Ala Leu Ser Pro His Ser Ala Phe 
    290                 295                 300                 


Leu Leu Leu Gln Gly Val Glu Thr Leu Ser Leu Arg Ile Glu Arg His 
305                 310                 315                 320 


Ser Ala Asn Ala Gln Ala Leu Ala Glu Trp Leu Glu Gln Arg Asp Glu 
                325                 330                 335     


Val Ala Ala Val His Tyr Pro Gly Leu Pro Ser Asn Arg Trp Tyr Asp 
            340                 345                 350         


Ala Gly Gln Arg Tyr Leu Pro Arg Gly Gly Gly Ala Val Leu Ala Phe 
        355                 360                 365             


Glu Leu Arg Asp Gly Val Lys Ala Gly Lys Arg Phe Val Asp Ala Val 
    370                 375                 380                 


Glu Leu Phe Ser His Leu Ala Asn Ile Gly Asp Val Arg Ser Leu Ile 
385                 390                 395                 400 


Ile His Pro Ala Ser Thr Thr His Ser Gln Leu Asp Glu Glu Gln Leu 
                405                 410                 415     


Ala Ala Thr Gly Ala Ser Pro Gly Leu Val Arg Leu Ser Val Gly Ile 
            420                 425                 430         


Glu Asn Leu Ala Asp Leu Lys Ala Asp Leu Glu Ala Gly Phe Arg Ala 
        435                 440                 445             


Ala Lys Gly Ala 
    450         


<210> 40
<211> 420
<212> PRT
<213> Clostridium saccharobutylicum

<400> 40
Met Lys Ile Glu Thr Lys Cys Leu His Glu Gly Tyr Lys Pro Gln Asn 
1               5                   10                  15      


Gly Glu Pro Val Ala Leu Pro Ile Tyr Gln Ser Ile Thr Tyr Arg Tyr 
            20                  25                  30          


Asp Asn Ala Asp Glu Ile Gly Lys Leu Phe Asp Leu Thr Ser Ser Gly 
        35                  40                  45              


His Met Tyr Ser Arg Ile Ser Asn Pro Thr Val Ala Ala Val Glu Glu 
    50                  55                  60                  


Lys Ile Ala Ala Leu Glu Gly Gly Val Ala Ala Leu Cys Thr Thr Ser 
65                  70                  75                  80  


Gly Gln Ala Ala Ala Leu Ile Ser Ile Leu Asn Ile Leu Ser Ala Gly 
                85                  90                  95      


Asp His Ile Val Ser Val Ser Thr Ile Tyr Gly Gly Thr Ile Asn Leu 
            100                 105                 110         


Phe Ala Val Thr Leu Lys Lys Phe Gly Ile Gln Cys Thr Phe Val Asp 
        115                 120                 125             


Ala Glu Ala Ser Glu Glu Glu Ile Gln Lys Ala Phe Lys Ala Asn Thr 
    130                 135                 140                 


Lys Val Val Phe Gly Glu Thr Ile Ala Asn Pro Ala Ile Ala Ile Phe 
145                 150                 155                 160 


Asp Ile Glu Lys Phe Ala Asn Ile Ala His Lys Asn Asn Val Pro Leu 
                165                 170                 175     


Ile Ile Asp Asn Thr Phe Ala Thr Pro Ile Leu Cys Arg Pro Ile Glu 
            180                 185                 190         


Phe Gly Ala Asp Ile Val Ile His Ser Thr Ser Lys Tyr Met Asp Gly 
        195                 200                 205             


His Ala Val Gln Ile Gly Gly Val Ile Val Asp Ser Gly Lys Phe Asp 
    210                 215                 220                 


Trp Thr Asn Gly Lys Phe Pro Glu Phe Thr Glu Pro Asp Ala Ser Tyr 
225                 230                 235                 240 


His Gly Ile Val Tyr Thr Glu Lys Phe Gly Ser Ala Ala Tyr Ile Thr 
                245                 250                 255     


Lys Ala Arg Val Gln Leu Met Arg Asp Leu Gly Ala Tyr Pro Ser Ala 
            260                 265                 270         


Asn Ala Ala Phe Leu Leu Asn Leu Gly Leu Glu Ser Leu Pro Val Arg 
        275                 280                 285             


Ile Glu Lys His Cys Arg Asn Ala Glu Ala Val Ala Glu Phe Leu Asn 
    290                 295                 300                 


Ser Asn Asp Lys Val Glu Phe Val Asn Tyr Pro Thr Ile Lys Cys Asn 
305                 310                 315                 320 


Lys Tyr Asn Asp Leu Ala Lys Lys Tyr Leu Pro Asn Gly Cys Ser Gly 
                325                 330                 335     


Val Ile Ser Phe Ser Ile Lys Gly Asp Arg Asp Asp Ala Ile Arg Phe 
            340                 345                 350         


Met Asn Ser Leu Lys Leu Ile Glu Asn Val Val His Val Ala Asp Ile 
        355                 360                 365             


Arg Thr Ser Val Leu His Pro Ala Ser Ser Thr His Arg Gln Leu Thr 
    370                 375                 380                 


Asp Glu Gln Leu Val Ala Ala Gly Ile Thr Pro Gly Leu Ile Arg Ile 
385                 390                 395                 400 


Ser Val Gly Leu Glu Asn Ile Asp Asp Ile Ile Glu Asp Ile Lys Gln 
                405                 410                 415     


Ala Leu Glu Gln 
            420 


<210> 41
<211> 390
<212> PRT
<213> Bacillus mycoides

<400> 41
Met Lys Lys Lys His Met Glu Thr Ala Leu Ile His His Gly Tyr Thr 
1               5                   10                  15      


Ser Glu Glu His Lys Gly Ser Leu Thr Pro Pro Leu Phe Gln Thr Ser 
            20                  25                  30          


Thr Phe Thr Phe Glu Thr Ala Gln Gln Gly Glu Ala Ser Phe Ala Gly 
        35                  40                  45              


Val Asp Pro Ser Tyr Ile Tyr Ser Arg Leu Gly Asn Pro Thr Val Lys 
    50                  55                  60                  


Leu Phe Glu Glu Arg Met Ala Val Leu Glu Gly Gly Glu Glu Ala Leu 
65                  70                  75                  80  


Ala Phe Gly Ser Gly Met Ala Ala Ile Ser Ala Thr Leu Ile Gly Phe 
                85                  90                  95      


Leu Lys Ala Gly Asp His Ile Ile Cys Ser Asn Gly Leu Tyr Gly Cys 
            100                 105                 110         


Thr Tyr Gly Phe Leu Glu Val Leu Glu Glu Lys Phe Met Ile Thr His 
        115                 120                 125             


Ser Phe Cys Asp Met Glu Thr Glu Thr Asp Ile Glu Asn Lys Ile Arg 
    130                 135                 140                 


Pro Asn Thr Lys Leu Ile Phe Val Glu Thr Pro Ile Asn Pro Thr Met 
145                 150                 155                 160 


Lys Leu Ile Asp Leu Glu Lys Val Ile Gly Val Ala Lys Arg Asn Asp 
                165                 170                 175     


Leu Leu Val Ile Val Asp Asn Thr Phe Cys Ser Pro Tyr Leu Gln Arg 
            180                 185                 190         


Pro Leu Glu Leu Gly Cys Asp Ala Val Val His Ser Ala Thr Lys Tyr 
        195                 200                 205             


Ile Gly Gly His Gly Asp Val Val Ala Gly Val Thr Ile Cys Lys Thr 
    210                 215                 220                 


Lys Ala Leu Ala Glu Lys Ile Arg Pro Met Arg Lys Asp Ile Gly Gly 
225                 230                 235                 240 


Ile Met Ala Pro Phe Asp Ala Trp Leu Leu Leu Arg Gly Leu Lys Thr 
                245                 250                 255     


Leu Ala Val Arg Met Asp Arg His Cys Asp Asn Ala Glu Lys Ile Val 
            260                 265                 270         


Ser Phe Leu Lys Asn His Asp Ala Val Glu Gly Val Trp Tyr Pro Glu 
        275                 280                 285             


Gly Glu Leu Ala Ser Arg Gln Met Lys Arg Gly Gly Gly Val Ile Ser 
    290                 295                 300                 


Phe Ser Ile Lys Gly Gly Lys Glu Glu Thr Gln Ala Phe Ile Asn Asp 
305                 310                 315                 320 


Leu Tyr Phe Ile Thr Ile Ala Val Ser Leu Gly Asp Thr Glu Thr Leu 
                325                 330                 335     


Ile Gln His Pro Ala Thr Met Thr His Ala Ala Ile Pro Ala Asp Leu 
            340                 345                 350         


Arg Lys Glu Met Gly Ile Tyr Asp Asn Leu Ile Arg Leu Ser Val Gly 
        355                 360                 365             


Leu Glu Ser Trp Glu Asp Ile Val Ser Asp Leu Glu Gln Ala Leu Lys 
    370                 375                 380                 


Lys Ile Ser Thr Val Asn 
385                 390 


<210> 42
<211> 429
<212> PRT
<213> Bordetella trematum

<400> 42
Met Ser Asp Ser Asn Lys Asn Trp Arg Leu Glu Thr Ile Ala Val His 
1               5                   10                  15      


Gly Gly Tyr Arg Pro Asp Pro Thr Thr Arg Ala Val Ala Val Pro Ile 
            20                  25                  30          


Tyr Gln Thr Val Ala Tyr Ala Phe Asp Asp Thr Gln His Gly Ala Asp 
        35                  40                  45              


Leu Phe Asp Leu Lys Val Pro Gly Asn Ile Tyr Thr Arg Ile Met Asn 
    50                  55                  60                  


Pro Thr Asn Asp Val Leu Glu Gln Arg Val Ala Ala Leu Glu Gly Gly 
65                  70                  75                  80  


Ile Ala Ala Leu Ala Leu Ala Ser Gly Gln Ala Ala Val Thr Tyr Ser 
                85                  90                  95      


Ile Leu Thr Leu Ala Glu Ala Gly Asp Asn Ile Val Ser Ser Ser Thr 
            100                 105                 110         


Leu Tyr Gly Gly Thr Tyr Asn Leu Leu Ala His Thr Leu Pro Gln Tyr 
        115                 120                 125             


Gly Ile Ser Thr Arg Phe Ala Asp Pro Ser Asp Leu Ala Ser Phe Glu 
    130                 135                 140                 


Arg Gln Ile Asp Ala Arg Thr Lys Ala Ile Phe Ala Glu Ser Val Gly 
145                 150                 155                 160 


Asn Pro Leu Gly Asn Val Thr Asp Ile Gln Ala Leu Ala Asp Leu Ala 
                165                 170                 175     


His Arg His Gly Val Pro Leu Ile Val Asp Asn Thr Val Pro Ser Pro 
            180                 185                 190         


Tyr Leu Leu Arg Pro Ile Glu His Gly Ala Asp Ile Val Val Gln Ser 
        195                 200                 205             


Leu Thr Lys Tyr Leu Gly Gly His Gly Thr Ser Leu Gly Gly Ala Ile 
    210                 215                 220                 


Ile Asp Ser Gly Lys Phe Pro Trp Ala Gln His Lys Glu Arg Phe Lys 
225                 230                 235                 240 


Arg Leu Asn Glu Pro Asp Val Ser Tyr His Gly Val Val Tyr Thr Glu 
                245                 250                 255     


Ala Phe Gly Ala Ala Ala Tyr Ile Gly Arg Ala Arg Val Val Pro Leu 
            260                 265                 270         


Arg Asn Thr Gly Ala Ala Leu Ser Pro Phe Asn Ala Phe Gln Ile Leu 
        275                 280                 285             


Gln Gly Ile Glu Thr Leu Ala Leu Arg Val Asp Arg Ile Val Glu Asn 
    290                 295                 300                 


Ala Val Arg Ile Ala Gln Tyr Leu Lys Gln His Pro Lys Val Glu Trp 
305                 310                 315                 320 


Val Asn Tyr Ala Gly Leu Pro Glu His Pro Asp His Ala Leu Val Gln 
                325                 330                 335     


Lys Tyr Leu Gly Gly Lys Ala Pro Gly Leu Phe Thr Phe Gly Val Lys 
            340                 345                 350         


Gly Gly Arg Glu Ala Gly Ala Arg Phe Gln Asp Ala Leu Asn Leu Phe 
        355                 360                 365             


Thr Arg Leu Val Asn Ile Gly Asp Ala Lys Ser Leu Ala Thr His Pro 
    370                 375                 380                 


Ala Ser Thr Thr His Arg Gln Leu Asn Pro Glu Glu Leu Ala Lys Ala 
385                 390                 395                 400 


Gly Val Arg Glu Glu Thr Val Arg Leu Ser Ile Gly Ile Glu His Ile 
                405                 410                 415     


Asp Asp Leu Ile Ala Asp Leu Asp Gln Ala Leu Ala Gln 
            420                 425                 


<210> 43
<211> 398
<212> PRT
<213> Citrobacter freundii

<400> 43
Met Ser Asp Cys Arg Thr Tyr Gly Phe Asn Thr Gln Ile Val His Ala 
1               5                   10                  15      


Gly Gln Gln Pro Asp Pro Ser Thr Gly Ala Leu Ser Thr Pro Ile Phe 
            20                  25                  30          


Gln Thr Ser Thr Phe Val Phe Asp Ser Ala Glu Gln Gly Ala Ala Arg 
        35                  40                  45              


Phe Ala Leu Glu Glu Ser Gly Tyr Ile Tyr Thr Arg Leu Gly Asn Pro 
    50                  55                  60                  


Thr Thr Asp Ala Leu Glu Lys Lys Leu Ala Val Leu Glu Arg Gly Glu 
65                  70                  75                  80  


Ala Gly Leu Ala Thr Ala Ser Gly Ile Ser Ala Ile Thr Thr Thr Leu 
                85                  90                  95      


Leu Thr Leu Cys Gln Gln Gly Asp His Ile Val Ser Ala Ser Ala Ile 
            100                 105                 110         


Tyr Gly Cys Thr His Ala Phe Leu Ser His Ser Met Pro Lys Phe Gly 
        115                 120                 125             


Ile Asn Val Arg Leu Val Asp Ala Gly Lys Pro Glu Glu Ile Arg Ala 
    130                 135                 140                 


Ala Met Arg Pro Glu Thr Lys Val Val Tyr Ile Glu Thr Pro Ala Asn 
145                 150                 155                 160 


Pro Thr Leu Ser Leu Val Asp Ile Glu Thr Val Ala Gly Ile Ala His 
                165                 170                 175     


Gln Gln Gly Ala Leu Leu Val Val Asp Asn Thr Phe Met Ser Pro Tyr 
            180                 185                 190         


Cys Gln Gln Pro Leu Gln Leu Gly Ala Asp Ile Val Val His Ser Val 
        195                 200                 205             


Thr Lys Tyr Ile Asn Gly His Gly Asp Val Ile Gly Gly Ile Ile Val 
    210                 215                 220                 


Gly Lys Gln Glu Phe Ile Asp Gln Ala Arg Phe Val Gly Leu Lys Asp 
225                 230                 235                 240 


Ile Thr Gly Gly Cys Met Ser Pro Phe Asn Ala Trp Leu Thr Leu Arg 
                245                 250                 255     


Gly Val Lys Thr Leu Gly Ile Arg Met Glu Arg His Cys Glu Asn Ala 
            260                 265                 270         


Leu Lys Ile Ala Arg Phe Leu Glu Gly His Pro Ser Ile Thr Arg Val 
        275                 280                 285             


Tyr Tyr Pro Gly Leu Ser Ser His Pro Gln Tyr Glu Leu Gly Gln Arg 
    290                 295                 300                 


Gln Met Ser Leu Pro Gly Gly Ile Ile Ser Phe Glu Ile Ala Gly Gly 
305                 310                 315                 320 


Leu Glu Ala Gly Arg Arg Met Ile Asn Ser Val Glu Leu Cys Leu Leu 
                325                 330                 335     


Ala Val Ser Leu Gly Asp Thr Glu Thr Leu Ile Gln His Pro Ala Ser 
            340                 345                 350         


Met Thr His Ser Pro Val Ala Pro Glu Glu Arg Leu Lys Ala Gly Ile 
        355                 360                 365             


Thr Asp Gly Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Pro Glu Asp 
    370                 375                 380                 


Ile Ile Asn Asp Leu Glu His Ala Ile Arg Lys Ala Thr Phe 
385                 390                 395             


<210> 44
<211> 389
<212> PRT
<213> Entamoeba histolytica

<400> 44
Met Thr Ala Gln Asp Ile Thr Thr Thr Leu Leu His Pro Lys Gly Asp 
1               5                   10                  15      


His Val Leu His Ser His Ala Tyr Pro Ile Phe Gln Thr Ser Thr Phe 
            20                  25                  30          


Cys Phe Asp Ser Thr Gln Gln Gly Ala Asp Leu Phe Met Gly Lys Gly 
        35                  40                  45              


Glu Gly His Ile Tyr Ser Arg Leu Gly Asn Pro Thr Val Glu Gln Phe 
    50                  55                  60                  


Glu Glu Met Val Cys Ser Ile Glu Gly Ala Ala Gly Ser Ala Ala Phe 
65                  70                  75                  80  


Gly Ser Gly Met Gly Ala Ile Ser Ser Ser Thr Leu Ala Phe Leu Gln 
                85                  90                  95      


Lys Gly Asp His Leu Ile Ala Gly Asp Thr Leu Tyr Gly Cys Thr Val 
            100                 105                 110         


Ser Leu Phe Thr His Trp Leu Pro Arg Phe Gly Ile Glu Val Asp Leu 
        115                 120                 125             


Ile Asp Thr Ser Asp Val Glu Lys Val Lys Ala Ala Trp Lys Pro Asn 
    130                 135                 140                 


Thr Lys Met Val Tyr Leu Glu Ser Pro Ala Asn Pro Thr Cys Lys Val 
145                 150                 155                 160 


Ser Asp Ile Lys Gly Ile Ala Val Val Cys His Glu Arg Gly Ala Arg 
                165                 170                 175     


Leu Val Val Asp Ala Thr Phe Thr Ser Pro Cys Phe Leu Lys Pro Leu 
            180                 185                 190         


Glu Leu Gly Ala Asp Ile Ala Leu His Ser Val Ser Lys Tyr Ile Asn 
        195                 200                 205             


Gly His Gly Asp Val Ile Gly Gly Val Ser Ser Ala Lys Thr Ala Glu 
    210                 215                 220                 


Asp Ile Ala Thr Ile Lys Phe Tyr Arg Lys Asp Ala Gly Ser Leu Met 
225                 230                 235                 240 


Ala Pro Met Asp Ala Phe Leu Cys Ala Arg Gly Met Lys Thr Leu Pro 
                245                 250                 255     


Ile Arg Met Gln Ile His Met Glu Asn Gly Leu Lys Val Ala Lys Phe 
            260                 265                 270         


Leu Glu Gln His Glu Lys Ile Val Lys Val Asn His Pro Gly Leu Glu 
        275                 280                 285             


Ser Phe Pro Gly His Asp Ile Ala Lys Lys Gln Met Thr Gly Tyr Gly 
    290                 295                 300                 


Ser Thr Phe Ser Phe Glu Met Lys Ser Phe Glu Ala Ala Lys Lys Leu 
305                 310                 315                 320 


Met Glu His Leu Lys Val Cys Thr Leu Ala Val Ser Leu Gly Cys Val 
                325                 330                 335     


Asp Thr Leu Ile Glu His Pro Ala Ser Met Thr His Ala Ala Val Pro 
            340                 345                 350         


Glu Asn Ile Met Arg Lys Gln Gly Ile Thr Pro Glu Leu Val Arg Ile 
        355                 360                 365             


Ser Val Gly Ile Glu Asn Val Asp Asp Ile Ile Ala Asp Leu Lys Gln 
    370                 375                 380                 


Ala Leu Glu Leu Trp 
385                 


<210> 45
<211> 424
<212> PRT
<213> Yersinia frederiksenii

<400> 45
Met Lys Leu Glu Thr Leu Ser Ile His Ala Gly Tyr Ser Pro Asp Pro 
1               5                   10                  15      


Thr Thr Lys Ala Val Ala Val Pro Ile Tyr Gln Thr Ser Ser Phe Ala 
            20                  25                  30          


Phe Asp Asp Thr Gln His Gly Ala Asp Leu Phe Asp Leu Lys Val Ala 
        35                  40                  45              


Gly Asn Ile Tyr Ser Arg Ile Met Asn Pro Thr Asn Asp Val Leu Glu 
    50                  55                  60                  


Lys Arg Val Ala Ala Leu Glu Gly Gly Ile Ala Ala Leu Ala Val Ala 
65                  70                  75                  80  


Ser Gly Met Ala Ala Ile Thr Tyr Ala Ile Gln Thr Ile Ala Glu Val 
                85                  90                  95      


Gly Asp Asn Ile Val Ser Val Ala Lys Leu Tyr Gly Gly Thr Tyr Asn 
            100                 105                 110         


Leu Leu Ala His Thr Leu Pro Arg Tyr Gly Ile Glu Thr Arg Phe Ala 
        115                 120                 125             


Asp His Asp Asp Ile Ala Ala Leu Glu Ala Leu Ile Asp Asp Arg Thr 
    130                 135                 140                 


Lys Ala Val Phe Cys Glu Ser Ile Gly Asn Pro Ala Gly Asn Ile Val 
145                 150                 155                 160 


Asp Leu Lys Lys Leu Ala Asp Ala Ala His Arg His Gly Val Pro Leu 
                165                 170                 175     


Ile Val Asp Asn Thr Val Ala Thr Pro Ile Leu Cys Arg Pro Phe Glu 
            180                 185                 190         


His Gly Ala Asp Ile Val Val His Ser Leu Thr Lys Tyr Ile Gly Gly 
        195                 200                 205             


His Gly Ser Ser Ile Gly Gly Ile Val Val Asp Ser Gly Lys Phe Pro 
    210                 215                 220                 


Trp Ala Gln Tyr Pro Glu Arg Phe Ala Gln Leu Asn Thr Pro Asp Pro 
225                 230                 235                 240 


Ser Tyr His Gly Val Thr Tyr Thr Glu Gln Phe Gly Ala Ala Ala Tyr 
                245                 250                 255     


Ile Gly Arg Cys Arg Val Val Pro Leu Arg Asn Thr Gly Ala Ala Leu 
            260                 265                 270         


Ser Pro Phe Asn Ala Phe Leu Ile Leu Gln Gly Leu Glu Thr Leu Ala 
        275                 280                 285             


Leu Arg Met Glu Arg His Thr Glu Asn Ala Leu Lys Val Ala His Tyr 
    290                 295                 300                 


Leu Gln Asn His Pro Gln Val Ser Trp Val Lys Tyr Ala Gly Leu Pro 
305                 310                 315                 320 


Asp His Pro Glu His Glu Leu Ala Gln Arg Tyr Phe Gly Gly Lys Pro 
                325                 330                 335     


Ala Ser Ile Leu Ser Phe Gly Ile His Gly Gly Gln Glu Ala Gly Gly 
            340                 345                 350         


Arg Phe Ile Asp Ala Leu Asn Leu Ile Val Arg Leu Val Asn Ile Gly 
        355                 360                 365             


Asp Ala Lys Ser Leu Ala Cys His Pro Ala Ser Thr Thr His Arg Gln 
    370                 375                 380                 


Leu Asn Asp Glu Glu Leu Ile Lys Ala Gly Val Pro Arg Asp Met Val 
385                 390                 395                 400 


Arg Leu Ser Ile Gly Ile Glu His Ile Asp Asp Ile Leu Asn Asp Leu 
                405                 410                 415     


Ala Gln Ala Leu Asp Ala Ala Lys 
            420                 


<210> 46
<211> 431
<212> PRT
<213> Bacillus subtilis

<400> 46
Met Gly Glu Ser Trp Gly Lys Gly Thr Ile Cys Val Gln Gly Gly Tyr 
1               5                   10                  15      


Thr Pro Lys Asn Gly Glu Pro Arg Val Leu Pro Leu Tyr Gln Ser Thr 
            20                  25                  30          


Thr Tyr Lys Tyr Asp Thr Ser Asp Asp Leu Ala Ala Leu Phe Asn Leu 
        35                  40                  45              


Glu Ala Glu Gly Tyr Ile Tyr Thr Arg Ile Gly Asn Pro Thr Leu Ala 
    50                  55                  60                  


Ala Phe Glu Gln Lys Leu Ala Glu Leu Glu Gly Gly Val Gly Ala Val 
65                  70                  75                  80  


Ala Thr Ala Ser Gly Gln Ala Ala Ile Met Leu Ala Val Leu Asn Ile 
                85                  90                  95      


Cys Ser Ser Gly Asp His Leu Leu Cys Ser Ser Thr Val Tyr Gly Gly 
            100                 105                 110         


Thr Phe Asn Leu Phe Gly Val Ser Leu Arg Lys Leu Gly Ile Asp Val 
        115                 120                 125             


Thr Phe Phe Asn Pro Asn Leu Thr Ala Asp Glu Ile Val Ala Leu Ala 
    130                 135                 140                 


Asn Asp Lys Thr Lys Leu Val Tyr Ala Glu Ser Leu Gly Asn Pro Ala 
145                 150                 155                 160 


Met Asn Val Leu Asn Phe Lys Glu Phe Ser Asp Ala Ala Lys Glu Leu 
                165                 170                 175     


Glu Val Pro Phe Ile Val Asp Asn Thr Leu Ala Thr Pro Tyr Leu Cys 
            180                 185                 190         


Gln Ala Phe Glu His Gly Ala Asn Ile Ile Val His Ser Thr Thr Lys 
        195                 200                 205             


Tyr Ile Asp Gly His Ala Ser Ser Leu Gly Gly Ile Val Ile Asp Gly 
    210                 215                 220                 


Gly Asn Phe Asp Trp Thr Asn Gly Lys Tyr Pro Glu Leu Val Glu Pro 
225                 230                 235                 240 


Asp Pro Ser Tyr His Gly Val Ser Tyr Val Gln Asn Phe Gly Ala Ala 
                245                 250                 255     


Ala Tyr Ile Val Lys Ala Arg Val Gln Leu Leu Arg Asp Tyr Gly Asn 
            260                 265                 270         


Cys Met Ser Pro Phe Asn Ala Tyr Ile Ser Asn Ile Gly Leu Glu Thr 
        275                 280                 285             


Leu His Leu Arg Met Glu Arg His Ser Glu Asn Ala Leu Ala Val Ala 
    290                 295                 300                 


Lys Trp Leu Ala Asp His Glu Arg Ile Glu Trp Val Asn Tyr Pro Gly 
305                 310                 315                 320 


Leu Asp Ser Asn Glu Asn Tyr Ser Leu Ala Gln Lys Tyr Leu Lys Lys 
                325                 330                 335     


Gly Ala Ser Gly Val Leu Thr Phe Gly Ile Lys Gly Gly Leu Glu Ala 
            340                 345                 350         


Ala Lys Glu Phe Ile Ala Asn Val Lys Leu Ala Thr Leu Val Thr His 
        355                 360                 365             


Val Ala Asp Ala Arg Thr Cys Val Ile His Pro Ala Ser Thr Thr His 
    370                 375                 380                 


Arg Gln Leu Ser Ala Glu Asp Gln Arg Leu Ala Gly Val Thr Ser Asp 
385                 390                 395                 400 


Leu Ile Arg Leu Ser Val Gly Ile Glu Asp Val Ser Asp Ile Ile Ala 
                405                 410                 415     


Asp Leu Glu Ala Ala Leu Val Gly Gly Lys Gln His Ala Asp His 
            420                 425                 430     


<210> 47
<211> 397
<212> PRT
<213> Pseudomonas putida

<400> 47
Met His Gly Ser Asn Lys Leu Pro Gly Phe Ala Thr Arg Ala Ile His 
1               5                   10                  15      


His Gly Tyr Asp Pro Gln Asp His Gly Gly Ala Leu Val Pro Pro Val 
            20                  25                  30          


Tyr Gln Thr Ala Thr Phe Thr Phe Pro Thr Val Glu Tyr Gly Ala Ala 
        35                  40                  45              


Cys Phe Ala Gly Glu Gln Ala Gly His Phe Tyr Ser Arg Ile Ser Asn 
    50                  55                  60                  


Pro Thr Leu Asn Leu Leu Glu Ala Arg Met Ala Ser Leu Glu Gly Gly 
65                  70                  75                  80  


Glu Ala Gly Leu Ala Leu Ala Ser Gly Met Gly Ala Ile Thr Ser Thr 
                85                  90                  95      


Leu Trp Thr Leu Leu Arg Pro Gly Asp Glu Val Leu Leu Gly Asn Thr 
            100                 105                 110         


Leu Tyr Gly His Thr Phe Ala Phe Leu His His Gly Ile Gly Glu Phe 
        115                 120                 125             


Gly Val Lys Leu Arg His Val Asp Met Ala Asp Leu Gln Ala Leu Glu 
    130                 135                 140                 


Ala Ala Met Thr Pro Ala Thr Arg Val Ile Tyr Phe Glu Ser Pro Ala 
145                 150                 155                 160 


Asn Pro Asn Met His Met Ala Asp Ile Ala Gly Val Ala Lys Ile Ala 
                165                 170                 175     


Arg Lys His Gly Ala Thr Val Val Val Asp Asn Thr Tyr Cys Thr Pro 
            180                 185                 190         


Tyr Leu Gln Arg Pro Leu Glu Leu Gly Ala Asp Leu Val Val His Ser 
        195                 200                 205             


Ala Thr Lys Tyr Leu Ser Gly His Gly Asp Ile Thr Ala Gly Ile Val 
    210                 215                 220                 


Val Gly Ser Gln Ala Leu Val Asp Arg Ile Arg Leu Gln Gly Leu Lys 
225                 230                 235                 240 


Asp Met Thr Gly Ala Val Leu Ser Pro His Asp Ala Ala Leu Leu Met 
                245                 250                 255     


Arg Gly Ile Lys Thr Leu Asn Leu Arg Met Asp Arg His Cys Ala Asn 
            260                 265                 270         


Ala Gln Val Leu Ala Glu Phe Leu Ala Arg Gln Pro Gln Val Glu Leu 
        275                 280                 285             


Ile His Tyr Pro Gly Leu Ala Ser Phe Pro Gln Tyr Thr Leu Ala Arg 
    290                 295                 300                 


Gln Gln Met Ser Gln Pro Gly Gly Met Ile Ala Phe Glu Leu Lys Gly 
305                 310                 315                 320 


Gly Ile Gly Ala Gly Arg Arg Phe Met Asn Ala Leu Gln Leu Phe Ser 
                325                 330                 335     


Arg Ala Val Ser Leu Gly Asp Ala Glu Ser Leu Ala Gln His Pro Ala 
            340                 345                 350         


Ser Met Thr His Ser Ser Tyr Thr Pro Glu Glu Arg Ala His Tyr Gly 
        355                 360                 365             


Ile Ser Glu Gly Leu Val Arg Leu Ser Val Gly Leu Glu Asp Ile Asp 
    370                 375                 380                 


Asp Leu Leu Ala Asp Val Gln Gln Ala Leu Lys Ala Ser 
385                 390                 395         


<210> 48
<211> 563
<212> PRT
<213> Homo sapiens

<400> 48
Met Ala Phe Asn Asp Leu Leu Gln Gln Val Gly Gly Val Gly Arg Phe 
1               5                   10                  15      


Gln Gln Ile Gln Val Thr Leu Val Val Leu Pro Leu Leu Leu Met Ala 
            20                  25                  30          


Ser His Asn Thr Leu Gln Asn Phe Thr Ala Ala Ile Pro Thr His His 
        35                  40                  45              


Cys Arg Pro Pro Ala Asp Ala Asn Leu Ser Lys Asn Gly Gly Leu Glu 
    50                  55                  60                  


Val Trp Leu Pro Arg Asp Arg Gln Gly Gln Pro Glu Ser Cys Leu Arg 
65                  70                  75                  80  


Phe Thr Ser Pro Gln Trp Gly Leu Pro Phe Leu Asn Gly Thr Glu Ala 
                85                  90                  95      


Asn Gly Thr Gly Ala Thr Glu Pro Cys Thr Asp Gly Trp Ile Tyr Asp 
            100                 105                 110         


Asn Ser Thr Phe Pro Ser Thr Ile Val Thr Glu Trp Asp Leu Val Cys 
        115                 120                 125             


Ser His Arg Ala Leu Arg Gln Leu Ala Gln Ser Leu Tyr Met Val Gly 
    130                 135                 140                 


Val Leu Leu Gly Ala Met Val Phe Gly Tyr Leu Ala Asp Arg Leu Gly 
145                 150                 155                 160 


Arg Arg Lys Val Leu Ile Leu Asn Tyr Leu Gln Thr Ala Val Ser Gly 
                165                 170                 175     


Thr Cys Ala Ala Phe Ala Pro Asn Phe Pro Ile Tyr Cys Ala Phe Arg 
            180                 185                 190         


Leu Leu Ser Gly Met Ala Leu Ala Gly Ile Ser Leu Asn Cys Met Thr 
        195                 200                 205             


Leu Asn Val Glu Trp Met Pro Ile His Thr Arg Ala Cys Val Gly Thr 
    210                 215                 220                 


Leu Ile Gly Tyr Val Tyr Ser Leu Gly Gln Phe Leu Leu Ala Gly Val 
225                 230                 235                 240 


Ala Tyr Ala Val Pro His Trp Arg His Leu Gln Leu Leu Val Ser Ala 
                245                 250                 255     


Pro Phe Phe Ala Phe Phe Ile Tyr Ser Trp Phe Phe Ile Glu Ser Ala 
            260                 265                 270         


Arg Trp His Ser Ser Ser Gly Arg Leu Asp Leu Thr Leu Arg Ala Leu 
        275                 280                 285             


Gln Arg Val Ala Arg Ile Asn Gly Lys Arg Glu Glu Gly Ala Lys Leu 
    290                 295                 300                 


Ser Met Glu Val Leu Arg Ala Ser Leu Gln Lys Glu Leu Thr Met Gly 
305                 310                 315                 320 


Lys Gly Gln Ala Ser Ala Met Glu Leu Leu Arg Cys Pro Thr Leu Arg 
                325                 330                 335     


His Leu Phe Leu Cys Leu Ser Met Leu Trp Phe Ala Thr Ser Phe Ala 
            340                 345                 350         


Tyr Tyr Gly Leu Val Met Asp Leu Gln Gly Phe Gly Val Ser Ile Tyr 
        355                 360                 365             


Leu Ile Gln Val Ile Phe Gly Ala Val Asp Leu Pro Ala Lys Leu Val 
    370                 375                 380                 


Gly Phe Leu Val Ile Asn Ser Leu Gly Arg Arg Pro Ala Gln Met Ala 
385                 390                 395                 400 


Ala Leu Leu Leu Ala Gly Ile Cys Ile Leu Leu Asn Gly Val Ile Pro 
                405                 410                 415     


Gln Asp Gln Ser Ile Val Arg Thr Ser Leu Ala Val Leu Gly Lys Gly 
            420                 425                 430         


Cys Leu Ala Ala Ser Phe Asn Cys Ile Phe Leu Tyr Thr Gly Glu Leu 
        435                 440                 445             


Tyr Pro Thr Met Ile Arg Gln Thr Gly Met Gly Met Gly Ser Thr Met 
    450                 455                 460                 


Ala Arg Val Gly Ser Ile Val Ser Pro Leu Val Ser Met Thr Ala Glu 
465                 470                 475                 480 


Leu Tyr Pro Ser Met Pro Leu Phe Ile Tyr Gly Ala Val Pro Val Ala 
                485                 490                 495     


Ala Ser Ala Val Thr Val Leu Leu Pro Glu Thr Leu Gly Gln Pro Leu 
            500                 505                 510         


Pro Asp Thr Val Gln Asp Leu Glu Ser Arg Trp Ala Pro Thr Gln Lys 
        515                 520                 525             


Glu Ala Gly Ile Tyr Pro Arg Lys Gly Lys Gln Thr Arg Gln Gln Gln 
    530                 535                 540                 


Glu His Gln Lys Tyr Met Val Pro Leu Gln Ala Ser Ala Gln Glu Lys 
545                 550                 555                 560 


Asn Gly Leu 
            


<210> 49
<211> 515
<212> PRT
<213> Homo sapiens

<400> 49
Met Val Leu Ser Gln Glu Glu Pro Asp Ser Ala Arg Gly Thr Ser Glu 
1               5                   10                  15      


Ala Gln Pro Leu Gly Pro Ala Pro Thr Gly Ala Ala Pro Pro Pro Gly 
            20                  25                  30          


Pro Gly Pro Ser Asp Ser Pro Glu Ala Ala Val Glu Lys Val Glu Val 
        35                  40                  45              


Glu Leu Ala Gly Pro Ala Thr Ala Glu Pro His Glu Pro Pro Glu Pro 
    50                  55                  60                  


Pro Glu Gly Gly Trp Gly Trp Leu Val Met Leu Ala Ala Met Trp Cys 
65                  70                  75                  80  


Asn Gly Ser Val Phe Gly Ile Gln Asn Ala Cys Gly Val Leu Phe Val 
                85                  90                  95      


Ser Met Leu Glu Thr Phe Gly Ser Lys Asp Asp Asp Lys Met Val Phe 
            100                 105                 110         


Lys Thr Ala Trp Val Gly Ser Leu Ser Met Gly Met Ile Phe Phe Cys 
        115                 120                 125             


Cys Pro Ile Val Ser Val Phe Thr Asp Leu Phe Gly Cys Arg Lys Thr 
    130                 135                 140                 


Ala Val Val Gly Ala Ala Val Gly Phe Val Gly Leu Met Ser Ser Ser 
145                 150                 155                 160 


Phe Val Ser Ser Ile Glu Pro Leu Tyr Leu Thr Tyr Gly Ile Ile Phe 
                165                 170                 175     


Ala Cys Gly Cys Ser Phe Ala Tyr Gln Pro Ser Leu Val Ile Leu Gly 
            180                 185                 190         


His Tyr Phe Lys Lys Arg Leu Gly Leu Val Asn Gly Ile Val Thr Ala 
        195                 200                 205             


Gly Ser Ser Val Phe Thr Ile Leu Leu Pro Leu Leu Leu Arg Val Leu 
    210                 215                 220                 


Ile Asp Ser Val Gly Leu Phe Tyr Thr Leu Arg Val Leu Cys Ile Phe 
225                 230                 235                 240 


Met Phe Val Leu Phe Leu Ala Gly Phe Thr Tyr Arg Pro Leu Ala Thr 
                245                 250                 255     


Ser Thr Lys Asp Lys Glu Ser Gly Gly Ser Gly Ser Ser Leu Phe Ser 
            260                 265                 270         


Arg Lys Lys Phe Ser Pro Pro Lys Lys Ile Phe Asn Phe Ala Ile Phe 
        275                 280                 285             


Lys Val Thr Ala Tyr Ala Val Trp Ala Val Gly Ile Pro Leu Ala Leu 
    290                 295                 300                 


Phe Gly Tyr Phe Val Pro Tyr Val His Leu Met Lys His Val Asn Glu 
305                 310                 315                 320 


Arg Phe Gln Asp Glu Lys Asn Lys Glu Val Val Leu Met Cys Ile Gly 
                325                 330                 335     


Val Thr Ser Gly Val Gly Arg Leu Leu Phe Gly Arg Ile Ala Asp Tyr 
            340                 345                 350         


Val Pro Gly Val Lys Lys Val Tyr Leu Gln Val Leu Ser Phe Phe Phe 
        355                 360                 365             


Ile Gly Leu Met Ser Met Met Ile Pro Leu Cys Ser Ile Phe Gly Ala 
    370                 375                 380                 


Leu Ile Ala Val Cys Leu Ile Met Gly Leu Phe Asp Gly Cys Phe Ile 
385                 390                 395                 400 


Ser Ile Met Ala Pro Ile Ala Phe Glu Leu Val Gly Ala Gln Asp Val 
                405                 410                 415     


Ser Gln Ala Ile Gly Phe Leu Leu Gly Phe Met Ser Ile Pro Met Thr 
            420                 425                 430         


Val Gly Pro Pro Ile Ala Gly Leu Leu Arg Asp Lys Leu Gly Ser Tyr 
        435                 440                 445             


Asp Val Ala Phe Tyr Leu Ala Gly Val Pro Pro Leu Ile Gly Gly Ala 
    450                 455                 460                 


Val Leu Cys Phe Ile Pro Trp Ile His Ser Lys Lys Gln Arg Glu Ile 
465                 470                 475                 480 


Ser Lys Thr Thr Gly Lys Glu Lys Met Glu Lys Met Leu Glu Asn Gln 
                485                 490                 495     


Asn Ser Leu Leu Ser Ser Ser Ser Gly Met Phe Lys Lys Glu Ser Asp 
            500                 505                 510         


Ser Ile Ile 
        515 


<210> 50
<211> 405
<212> PRT
<213> Homo sapiens

<400> 50
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 51
<211> 398
<212> PRT
<213> Mus musculus

<400> 51
Met Gln Lys Asp Ala Ser Leu Ser Gly Phe Leu Pro Ser Phe Gln His 
1               5                   10                  15      


Phe Ala Thr Gln Ala Ile His Val Gly Gln Glu Pro Glu Gln Trp Asn 
            20                  25                  30          


Ser Arg Ala Val Val Leu Pro Ile Ser Leu Ala Thr Thr Phe Lys Gln 
        35                  40                  45              


Asp Phe Pro Gly Gln Ser Ser Gly Phe Glu Tyr Ser Arg Ser Gly Asn 
    50                  55                  60                  


Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly Ala 
65                  70                  75                  80  


Lys His Ser Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Ile Thr Ile 
                85                  90                  95      


Thr His Leu Leu Lys Ala Gly Asp Glu Ile Ile Cys Met Asp Glu Val 
            100                 105                 110         


Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Arg Val Ala Ser Glu Phe Gly 
        115                 120                 125             


Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Thr Lys Leu Leu Glu Ala 
    130                 135                 140                 


Ala Ile Thr Pro Gln Thr Lys Leu Val Trp Ile Glu Thr Pro Thr Asn 
145                 150                 155                 160 


Pro Thr Leu Lys Leu Ala Asp Ile Gly Ala Cys Ala Gln Ile Val His 
                165                 170                 175     


Lys Arg Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser Ala 
            180                 185                 190         


Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Cys Ser 
        195                 200                 205             


Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu Val 
    210                 215                 220                 


Ser Val Asn Ser Asp Asp Leu Asn Ser Arg Leu Arg Phe Leu Gln Asn 
225                 230                 235                 240 


Ser Leu Gly Ala Val Pro Ser Pro Phe Asp Cys Tyr Leu Cys Cys Arg 
                245                 250                 255     


Gly Leu Lys Thr Leu Gln Val Arg Met Glu Lys His Phe Lys Asn Gly 
            260                 265                 270         


Met Ala Val Ala Arg Phe Leu Glu Thr Asn Pro Arg Val Glu Lys Val 
        275                 280                 285             


Val Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Ala Lys Arg 
    290                 295                 300                 


Gln Cys Ser Gly Cys Pro Gly Met Val Ser Phe Tyr Ile Lys Gly Ala 
305                 310                 315                 320 


Leu Gln His Ala Lys Ala Phe Leu Lys Asn Leu Lys Leu Phe Thr Leu 
                325                 330                 335     


Ala Glu Ser Leu Gly Gly Tyr Glu Ser Leu Ala Glu Leu Pro Ala Ile 
            340                 345                 350         


Met Thr His Ala Ser Val Pro Glu Lys Asp Arg Ala Thr Leu Gly Ile 
        355                 360                 365             


Asn Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Gln Asp 
    370                 375                 380                 


Leu Leu Glu Asp Leu Asp Arg Ala Leu Lys Ala Ala His Pro 
385                 390                 395             


<210> 52
<211> 398
<212> PRT
<213> Rattus norvegicus

<400> 52
Met Gln Lys Asp Ala Ser Ser Ser Gly Phe Leu Pro Ser Phe Gln His 
1               5                   10                  15      


Phe Ala Thr Gln Ala Ile His Val Gly Gln Glu Pro Glu Gln Trp Ser 
            20                  25                  30          


Ser Arg Ala Val Val Leu Pro Ile Ser Leu Ala Thr Thr Phe Lys Gln 
        35                  40                  45              


Asp Ser Pro Gly Gln Ser Ser Gly Phe Val Tyr Ser Arg Ser Gly Asn 
    50                  55                  60                  


Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly Ala 
65                  70                  75                  80  


Lys His Cys Leu Thr Phe Ala Ser Gly Leu Ala Ala Thr Thr Thr Ile 
                85                  90                  95      


Thr His Leu Leu Lys Ala Gly Asp Glu Val Ile Cys Met Asp Glu Val 
            100                 105                 110         


Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Arg Val Ala Ser Glu Phe Gly 
        115                 120                 125             


Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Thr Lys Leu Leu Glu Ala 
    130                 135                 140                 


Ala Ile Thr Pro Gln Thr Lys Leu Val Trp Ile Glu Thr Pro Thr Asn 
145                 150                 155                 160 


Pro Thr Leu Lys Leu Ala Asp Ile Lys Ala Cys Ala Gln Ile Val His 
                165                 170                 175     


Lys His Lys Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser Ala 
            180                 185                 190         


Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Cys Ser 
        195                 200                 205             


Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu Val 
    210                 215                 220                 


Ser Val Asn Ser Asp Asp Leu Asn Glu Arg Leu Arg Phe Leu Gln Asn 
225                 230                 235                 240 


Ser Leu Gly Ala Val Pro Ser Pro Phe Asp Cys Tyr Leu Cys Cys Arg 
                245                 250                 255     


Gly Leu Lys Thr Leu Gln Ile Arg Met Glu Lys His Phe Arg Asn Gly 
            260                 265                 270         


Met Ala Val Ala Arg Phe Leu Glu Ser Asn Pro Arg Val Glu Lys Val 
        275                 280                 285             


Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Ala Lys Arg 
    290                 295                 300                 


Gln Cys Thr Gly Cys Pro Gly Met Val Ser Phe Tyr Ile Lys Gly Thr 
305                 310                 315                 320 


Leu Gln His Ala Gln Val Phe Leu Lys Asn Ile Lys Leu Phe Ala Leu 
                325                 330                 335     


Ala Glu Ser Leu Gly Gly Tyr Glu Ser Leu Ala Glu Leu Pro Ala Ile 
            340                 345                 350         


Met Thr His Ala Ser Val Pro Glu Lys Asp Arg Ala Thr Leu Gly Ile 
        355                 360                 365             


Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Lys Asp 
    370                 375                 380                 


Leu Leu Glu Asp Leu Gly Gln Ala Leu Lys Ala Ala His Pro 
385                 390                 395             


<210> 53
<211> 392
<212> PRT
<213> Saccharomyces cerevisiae

<400> 53
Met Thr Leu Gln Glu Ser Asp Lys Phe Ala Thr Lys Ala Ile His Ala 
1               5                   10                  15      


Gly Glu His Val Asp Val His Gly Ser Val Ile Glu Pro Ile Ser Leu 
            20                  25                  30          


Ser Thr Thr Phe Lys Gln Ser Ser Pro Ala Asn Pro Ile Gly Thr Tyr 
        35                  40                  45              


Glu Tyr Ser Arg Ser Gln Asn Pro Asn Arg Glu Asn Leu Glu Arg Ala 
    50                  55                  60                  


Val Ala Ala Leu Glu Asn Ala Gln Tyr Gly Leu Ala Phe Ser Ser Gly 
65                  70                  75                  80  


Ser Ala Thr Thr Ala Thr Ile Leu Gln Ser Leu Pro Gln Gly Ser His 
                85                  90                  95      


Ala Val Ser Ile Gly Asp Val Tyr Gly Gly Thr His Arg Tyr Phe Thr 
            100                 105                 110         


Lys Val Ala Asn Ala His Gly Val Glu Thr Ser Phe Thr Asn Asp Leu 
        115                 120                 125             


Leu Asn Asp Leu Pro Gln Leu Ile Lys Glu Asn Thr Lys Leu Val Trp 
    130                 135                 140                 


Ile Glu Thr Pro Thr Asn Pro Thr Leu Lys Val Thr Asp Ile Gln Lys 
145                 150                 155                 160 


Val Ala Asp Leu Ile Lys Lys His Ala Ala Gly Gln Asp Val Ile Leu 
                165                 170                 175     


Val Val Asp Asn Thr Phe Leu Ser Pro Tyr Ile Ser Asn Pro Leu Asn 
            180                 185                 190         


Phe Gly Ala Asp Ile Val Val His Ser Ala Thr Lys Tyr Ile Asn Gly 
        195                 200                 205             


His Ser Asp Val Val Leu Gly Val Leu Ala Thr Asn Asn Lys Pro Leu 
    210                 215                 220                 


Tyr Glu Arg Leu Gln Phe Leu Gln Asn Ala Ile Gly Ala Ile Pro Pro 
225                 230                 235                 240 


Phe Asp Ala Trp Leu Thr His Arg Gly Leu Lys Thr Leu His Leu Arg 
                245                 250                 255     


Val Arg Gln Ala Ala Leu Ser Ala Asn Lys Ile Ala Glu Phe Leu Ala 
            260                 265                 270         


Ala Asp Lys Glu Asn Val Val Ala Val Asn Tyr Pro Gly Leu Lys Thr 
        275                 280                 285             


His Pro Asn Tyr Asp Val Val Leu Lys Gln His Arg Asp Ala Leu Gly 
    290                 295                 300                 


Gly Gly Met Ile Ser Phe Arg Ile Lys Gly Gly Ala Glu Ala Ala Ser 
305                 310                 315                 320 


Lys Phe Ala Ser Ser Thr Arg Leu Phe Thr Leu Ala Glu Ser Leu Gly 
                325                 330                 335     


Gly Ile Glu Ser Leu Leu Glu Val Pro Ala Val Met Thr His Gly Gly 
            340                 345                 350         


Ile Pro Lys Glu Ala Arg Ala Ser Gly Val Phe Asp Asp Leu Val Arg 
        355                 360                 365             


Ile Ser Val Gly Ile Glu Asp Thr Asp Asp Leu Leu Glu Asp Ile Lys 
    370                 375                 380                 


Gln Ala Leu Lys Gln Ala Thr Asn 
385                 390         


<210> 54
<211> 417
<212> PRT
<213> Neurospora crassa

<400> 54
Met Thr Ala Ser Ser Asp His Pro Ile Thr Thr Pro Pro Arg Ala Pro 
1               5                   10                  15      


Ser Pro Val His Gly Phe Gly Thr Leu Ala Val His Ala Gly Ser Pro 
            20                  25                  30          


His Asp Pro Ala Thr Gly Ala Val Ile Glu Ala Ile Ser Leu Ser Thr 
        35                  40                  45              


Thr Phe Ala Gln Thr Ala Val Gly Lys Pro Val Gly Glu Phe Glu Tyr 
    50                  55                  60                  


Ser Arg Ser Ser Asn Pro Asn Arg Ala Asn Phe Glu Lys Met Val Ala 
65                  70                  75                  80  


Ala Leu Glu His Ala Lys Tyr Ala Leu Ala Tyr Ser Ser Gly Ser Ala 
                85                  90                  95      


Thr Thr Ala Asn Ile Leu Gln Ser Leu Ala Ala Gly Ser His Val Ile 
            100                 105                 110         


Ser Val Ser Asp Val Tyr Gly Gly Thr His Arg Tyr Phe Thr Gln Val 
        115                 120                 125             


Ala Lys Ala His Gly Val Lys Val Thr Phe Thr Pro Glu Ile Glu Val 
    130                 135                 140                 


Asp Ile Arg Asp His Ile Thr Asp Ala Thr Lys Leu Val Trp Ile Glu 
145                 150                 155                 160 


Thr Pro Ser Asn Pro Thr Leu Arg Leu Val Asp Ile Arg Ala Val Ala 
                165                 170                 175     


Thr Ala Ala His Glu Arg Gly Ile Leu Val Val Val Asp Asn Thr Phe 
            180                 185                 190         


Leu Ser Pro Tyr Val Gln Asn Pro Leu Asp His Gly Ala Asp Ile Val 
        195                 200                 205             


Val His Ser Val Thr Lys Tyr Ile Asn Gly His Ser Asp Val Val Met 
    210                 215                 220                 


Gly Val Ala Ala Phe Asn Ser Asp Glu Leu Tyr Ala Arg Leu Ser Phe 
225                 230                 235                 240 


Leu Gln Asn Ala Ile Gly Ala Val Pro Ser Ala Phe Asp Ser Trp Leu 
                245                 250                 255     


Ala His Arg Gly Ala Lys Thr Leu His Leu Arg Ala Arg Glu Ala Thr 
            260                 265                 270         


Thr Asn Ala Thr Ala Ile Ala His Ala Leu Glu Ala Ser Pro Leu Val 
        275                 280                 285             


Ile Ser Val Asn Tyr Pro Gly Leu Glu Ser His Pro His Arg Ala Ile 
    290                 295                 300                 


Ala Leu Lys Gln His Arg Asn Gly Met Gly Gly Gly Met Leu Ser Phe 
305                 310                 315                 320 


Arg Ile His Gly Gly His Ala Ala Ala Glu Lys Phe Cys Gln Tyr Thr 
                325                 330                 335     


Lys Ile Phe Thr Leu Ala Glu Ser Leu Gly Gly Val Glu Ser Leu Cys 
            340                 345                 350         


Glu Ile Pro Ser Ser Met Thr His Ala Gly Ile Pro Lys Ala Gln Arg 
        355                 360                 365             


Glu Ala Val Gly Ile Phe Asp Asp Leu Val Arg Ile Ser Cys Gly Val 
    370                 375                 380                 


Glu Asp Ala Glu Asp Leu Lys Ala Asp Val Leu Gln Ala Leu Glu Arg 
385                 390                 395                 400 


Ala Val Ala Asp Ala Ala Asn Gly Val Ser Asn Gly Val Asn Gly Thr 
                405                 410                 415     


His 
    


<210> 55
<211> 389
<212> PRT
<213> Leishmania major

<400> 55
Met Ser Ser Gln Gln His Leu Val Ser Asp Phe Thr Ala Gly Ser Gly 
1               5                   10                  15      


Ser Trp Leu Pro Gln Ser Gln Gly Phe Asp Thr Leu Gln Val His Ala 
            20                  25                  30          


Gly Val Arg Pro Asp Pro Val Thr Gly Ala Ile Leu Thr Pro Ile Tyr 
        35                  40                  45              


Gln Ser Thr Thr Phe Val Gln Glu Ser Ile Asn Ser Tyr Gln Ala Lys 
    50                  55                  60                  


Gly Tyr Ser Tyr Thr Arg Ser Ala Asn Pro Thr Val Ala Val Leu Glu 
65                  70                  75                  80  


Gln Lys Leu Cys Ala Leu Glu Asn Gly Ser Tyr Cys Thr Val Tyr Asn 
                85                  90                  95      


Thr Gly Met Ala Ala Thr Thr Thr Ala Ile Ser Ser Phe Met Asn Ala 
            100                 105                 110         


Gly Asp His Ala Ile Leu Thr Asn Cys Cys Tyr Gly Gly Thr Asn Arg 
        115                 120                 125             


Ala Cys Arg Val Phe Phe Ser Arg Leu Gly Met Glu Phe Thr Phe Val 
    130                 135                 140                 


Asp Met Arg Asp Pro Gln Asn Val Ile Asp Ser Ile Lys Pro Asn Thr 
145                 150                 155                 160 


Lys Leu Val Ile Ser Glu Thr Pro Ala Asn Pro Thr Leu Ile Leu Ile 
                165                 170                 175     


Asp Val Ala Ala Val Ser Lys Ile Cys Lys Glu Arg Gly Ile Val His 
            180                 185                 190         


Met Cys Asp Asn Thr Phe Ala Thr Ala Tyr Ile Met Arg Pro Leu Asp 
        195                 200                 205             


His Gly Ala Asp Val Thr Leu Ile Ser Thr Thr Lys Tyr Val Asp Gly 
    210                 215                 220                 


His Asp Met Thr Val Gly Gly Ala Leu Val Thr Asn Ser Lys Glu Leu 
225                 230                 235                 240 


Asp Ala Lys Val Arg Leu Thr Gln Asn Ile Leu Gly Asn Val Met Ser 
                245                 250                 255     


Pro Gln Val Ala Phe Leu Gln Leu Gln Thr Val Lys Thr Met Ser Leu 
            260                 265                 270         


Arg Val Thr Lys Gln Ser His Asn Ala Gln Lys Ile Ala Glu Phe Leu 
        275                 280                 285             


Glu Thr His Arg Ala Val Asp Arg Val Val Tyr Pro Gly Gly Met Leu 
    290                 295                 300                 


Trp Phe Glu Val Lys Gly Gly Thr Ala Ala Gly Arg Arg Leu Met Asp 
305                 310                 315                 320 


Thr Val Pro Arg Pro Trp Ser Leu Cys Glu Asn Leu Gly Ala Ser Glu 
                325                 330                 335     


Ser Ile Ile Thr Cys Pro Ser Val Met Thr His Ala Asn Met Thr Ser 
            340                 345                 350         


Glu Asp Arg Met Lys Val Gly Ile Thr Asp Gly Phe Val Arg Val Ser 
        355                 360                 365             


Cys Gly Ile Glu Asp Val Asp Asp Leu Ile Ala Ala Leu Lys Val Ala 
    370                 375                 380                 


Met Asp Ala Leu Val 
385                 


<210> 56
<211> 393
<212> PRT
<213> Corynebacterium ammoniagenes

<400> 56
Met Lys Phe Pro Thr Gln Asp Glu Leu Arg Ala Arg Phe Thr Arg Lys 
1               5                   10                  15      


Trp Thr Gln Phe Glu Pro Asp Val Leu Pro Leu Phe Ile Ala Glu Ser 
            20                  25                  30          


Asp Phe Pro Thr Ala Pro Val Ile Lys Glu Val Leu Leu Asp Tyr Thr 
        35                  40                  45              


Glu Arg Glu Cys Phe Gly Tyr Ser Pro Ala Pro Gly Thr Val Asp Leu 
    50                  55                  60                  


Gly Gly Ala Val Ser Glu Phe His Ala Lys Arg Tyr Gly Trp Arg Pro 
65                  70                  75                  80  


Asp Pro Lys Lys Val Phe Trp Ile Gly Asp Val Val Arg Gly Leu Leu 
                85                  90                  95      


Leu Gly Ile Gln Tyr Phe Thr Arg Pro Asp Ser Pro Val Val Val Pro 
            100                 105                 110         


Leu Pro Ala Tyr Pro Pro Phe Leu Glu Leu Pro Glu Thr Ala Gly Arg 
        115                 120                 125             


Lys Arg Ile Asp Val Gly Val Ser Pro Ala Asn Gly Asp Leu Lys Glu 
    130                 135                 140                 


Gly Glu Lys Pro Arg Leu Asp Leu Glu Ser Ile Glu Arg Ala Phe Ala 
145                 150                 155                 160 


Asp Gly Ala Gly Ser Ile Leu Leu Ala Asn Pro Tyr Asn Pro Leu Gly 
                165                 170                 175     


Tyr Val Phe Asp Glu Glu His Leu His Glu Leu Val Glu Leu Ala Asp 
            180                 185                 190         


Lys Tyr Asp Ala Arg Ile Leu Ser Asp Glu Ile His Ala Pro Leu Val 
        195                 200                 205             


Leu Asp Gly Gln His Ile Ser Val Ala Gly Leu Ser Asp Ala Ala Ala 
    210                 215                 220                 


Arg Val Thr Met Thr Ile Thr Ala Thr Ser Lys Ala Trp Asn Phe Ala 
225                 230                 235                 240 


Gly Leu Lys Cys Ala Gln Ile Ile Phe Ser Asn Asp Glu Asp Val Lys 
                245                 250                 255     


Thr Trp Asn Ser Leu Pro His Val Ala Gln Asp Gly Val Gly Thr Leu 
            260                 265                 270         


Gly Ile Ile Ala Ala Glu Ala Ala Tyr Arg Asp Gly Ile Pro His Leu 
        275                 280                 285             


Glu Glu Glu Ile Glu Tyr Leu Arg Ser Thr Arg Asp Trp Leu Val Glu 
    290                 295                 300                 


Glu Leu Pro Lys Arg Ile Pro Gly Leu Val Thr Ser Lys Pro Asp Ser 
305                 310                 315                 320 


Thr Tyr Leu Leu Trp Leu Asp Phe Arg Asn Thr Ala Ile Gly Asp Lys 
                325                 330                 335     


Glu His Pro Ala Ala Trp Leu Ile Gln His Ala Arg Val Ala Phe Asn 
            340                 345                 350         


Glu Gly Val Thr Phe Gly Glu Gly Gly Ala His Gln Ala Arg Met Asn 
        355                 360                 365             


Phe Ala Thr Ser Pro Glu Ile Leu Glu Glu Ala Ile Asp Arg Ile Ala 
    370                 375                 380                 


Thr Ala Ile Ala Lys Val Ser Asp Asn 
385                 390             


<210> 57
<211> 419
<212> PRT
<213> Emericella nidulans

<400> 57
Met Thr Met Met Ala Gly His Pro Asp Leu Pro Ser Asn Gly Gln Asn 
1               5                   10                  15      


Gly Asp Ser Asn Thr His Gln Gln Arg Gln Phe Ala Thr Leu Ala Val 
            20                  25                  30          


His Ala Gly Ala Pro His Asp Pro Thr Thr Gly Ala Val Ile Ala Pro 
        35                  40                  45              


Ile Ser Leu Ser Thr Thr Phe Ala Gln Glu Ser Val Gly Lys Pro Val 
    50                  55                  60                  


Gly Leu Tyr Glu Tyr Thr Arg Ser Ser Asn Pro Asn Arg Asp Asn Phe 
65                  70                  75                  80  


Glu Glu Ala Val Ala Ser Leu Glu His Ala Lys Tyr Ala Leu Ala Phe 
                85                  90                  95      


Ser Ser Gly Ser Ala Thr Thr Ala Thr Ile Leu His Ser Leu Ala Pro 
            100                 105                 110         


Gly Ser His Val Val Ser Val Ser Asp Val Tyr Gly Gly Thr His Arg 
        115                 120                 125             


Tyr Phe Thr Lys Val Ala Ala Ala His Gly Val Asn Val Ser Phe Ser 
    130                 135                 140                 


Ser Cys Leu Glu Leu Asp Val Glu Lys Leu Ile Arg Pro Asn Glu Thr 
145                 150                 155                 160 


Lys Leu Val Trp Ile Glu Thr Pro Ser Asn Pro Thr Leu Ala Leu Val 
                165                 170                 175     


Asp Ile Arg Lys Val Ala Ala Val Ala His Arg His Gly Val Leu Val 
            180                 185                 190         


Val Val Asp Asn Thr Phe Met Ser Pro Tyr Val Gln Asn Pro Leu Asp 
        195                 200                 205             


His Gly Ala Asp Val Val Ile His Ser Val Thr Lys Tyr Ile Asn Gly 
    210                 215                 220                 


His Ser Asp Val Leu Met Gly Val Ala Ala Phe Asn Ser Asp Glu Leu 
225                 230                 235                 240 


Lys Glu Arg Phe Thr Phe Leu Gln Asn Ala Ile Gly Ala Val Pro Ser 
                245                 250                 255     


Pro Phe Asp Cys Trp Leu Ala His Arg Gly Leu Lys Thr Leu His Leu 
            260                 265                 270         


Arg Ala Arg Glu Ala Thr Ala Asn Ala Thr Ala Val Ala Leu Ala Leu 
        275                 280                 285             


Glu Ser Ser Pro His Val Ile Ser Val Asn Tyr Pro Gly Leu Asn Ser 
    290                 295                 300                 


His Pro Asn Arg Glu Ile Ala Val Lys Gln His Arg Lys Gly Met Gly 
305                 310                 315                 320 


Gly Gly Met Leu Ser Phe Arg Ile Lys Gly Gly His Lys Ala Ala His 
                325                 330                 335     


Leu Phe Cys Glu Tyr Thr Lys Ile Phe Thr Leu Ala Glu Ser Leu Gly 
            340                 345                 350         


Gly Val Glu Ser Leu Cys Glu Val Pro Ser Ser Met Thr His Ala Gly 
        355                 360                 365             


Ile Pro Lys Glu Glu Arg Glu Ala Ala Gly Val Tyr Asp Asp Leu Val 
    370                 375                 380                 


Arg Met Ser Cys Gly Ile Glu Asp Val Glu Asp Leu Thr Ala Asp Thr 
385                 390                 395                 400 


Met Gln Ala Leu Glu Arg Ala Val Ala Ala Ser Gln Ala Leu Glu Asn 
                405                 410                 415     


Gly Ser Ala 
            


<210> 58
<211> 454
<212> PRT
<213> Arabidopsis thaliana

<400> 58
Met Glu Ala Gly Glu Arg Arg Asn Gly Asp Ser Met Ser His Asn His 
1               5                   10                  15      


Arg Ala Pro Lys Lys Pro Arg Leu Ala Gly Leu Leu Thr Glu Ser Asp 
            20                  25                  30          


Ile Asp Ser Glu Phe Ala His His Gln Thr Gly Val Ala Arg Ile Asn 
        35                  40                  45              


Asn Gly Ser Phe Gly Cys Cys Pro Gly Ser Val Leu Glu Ala Gln Arg 
    50                  55                  60                  


Glu Trp Gln Leu Arg Tyr Leu Arg Gln Pro Asp Glu Phe Tyr Phe Asn 
65                  70                  75                  80  


Gly Leu Arg Arg Gly Leu Leu Ala Ser Arg Thr Val Ile Ser Asp Leu 
                85                  90                  95      


Ile Asn Ala Asp Asp Val Asp Glu Val Ser Leu Val Asp Asn Ala Thr 
            100                 105                 110         


Thr Ala Ala Ala Ile Val Leu Gln Lys Val Gly Arg Cys Phe Ser Glu 
        115                 120                 125             


Gly Lys Tyr Lys Lys Glu Asp Thr Val Val Met Phe His Cys Ala Phe 
    130                 135                 140                 


Gln Ser Val Lys Lys Ser Ile Gln Ala Tyr Val Ser Arg Val Gly Gly 
145                 150                 155                 160 


Ser Thr Val Glu Val Arg Leu Pro Phe Pro Val Asn Ser Asn Glu Glu 
                165                 170                 175     


Ile Ile Ser Lys Phe Arg Glu Gly Leu Glu Lys Gly Arg Ala Asn Gly 
            180                 185                 190         


Arg Thr Val Arg Leu Ala Ile Ile Asp His Ile Thr Ser Met Pro Cys 
        195                 200                 205             


Val Leu Met Pro Val Arg Glu Leu Val Lys Ile Cys Arg Glu Glu Gly 
    210                 215                 220                 


Val Glu Gln Val Phe Val Asp Ala Ala His Ala Ile Gly Ser Val Lys 
225                 230                 235                 240 


Val Asp Val Lys Glu Ile Gly Ala Asp Tyr Tyr Val Ser Asn Leu His 
                245                 250                 255     


Lys Trp Phe Phe Cys Pro Pro Ser Ile Ala Phe Phe Tyr Cys Lys Lys 
            260                 265                 270         


Arg Gly Ser Glu Ser Asp Val His His Pro Val Val Ser His Glu Phe 
        275                 280                 285             


Gly Asn Gly Leu Pro Ile Glu Ser Ala Trp Ile Gly Thr Arg Asp Tyr 
    290                 295                 300                 


Ser Ser Gln Leu Val Val Pro Ser Val Met Glu Phe Val Asn Arg Phe 
305                 310                 315                 320 


Glu Gly Gly Met Glu Gly Ile Met Met Lys Asn His Asp Glu Ala Val 
                325                 330                 335     


Arg Met Gly Leu Met Leu Ala Asp Ala Trp Gly Thr Asn Leu Gly Ser 
            340                 345                 350         


Pro Pro Glu Met Cys Val Gly Met Val Met Ile Gly Leu Pro Ser Lys 
        355                 360                 365             


Leu Cys Val Gly Ser Asp Glu Asp Ala Ile Lys Leu Arg Ser Tyr Leu 
    370                 375                 380                 


Arg Val His Tyr Ser Val Glu Val Pro Val Phe Tyr Leu Gly Leu Arg 
385                 390                 395                 400 


Asp Gly Glu Glu Gly Val Lys Asp Lys Asp Ser Gly Leu Ile Thr Ala 
                405                 410                 415     


Tyr Val Arg Ile Ser His Gln Val Tyr Asn Lys Thr Glu Asp Tyr Glu 
            420                 425                 430         


Arg Leu Arg Asp Ala Ile Thr Glu Leu Val Lys Asp Gln Met Thr Cys 
        435                 440                 445             


Gln Asn Leu Pro Ala Leu 
    450                 


<210> 59
<211> 470
<212> PRT
<213> Homo sapiens

<400> 59
Met Asp Arg Gly Glu Lys Ile Gln Leu Lys Arg Val Phe Gly Tyr Trp 
1               5                   10                  15      


Trp Gly Thr Ser Phe Leu Leu Ile Asn Ile Ile Gly Ala Gly Ile Phe 
            20                  25                  30          


Val Ser Pro Lys Gly Val Leu Ala Tyr Ser Cys Met Asn Val Gly Val 
        35                  40                  45              


Ser Leu Cys Val Trp Ala Gly Cys Ala Ile Leu Ala Met Thr Ser Thr 
    50                  55                  60                  


Leu Cys Ser Ala Glu Ile Ser Ile Ser Phe Pro Cys Ser Gly Ala Gln 
65                  70                  75                  80  


Tyr Tyr Phe Leu Lys Arg Tyr Phe Gly Ser Thr Val Ala Phe Leu Asn 
                85                  90                  95      


Leu Trp Thr Ser Leu Phe Leu Gly Ser Gly Val Val Ala Gly Gln Ala 
            100                 105                 110         


Leu Leu Leu Ala Glu Tyr Ser Ile Gln Pro Phe Phe Pro Ser Cys Ser 
        115                 120                 125             


Val Pro Lys Leu Pro Lys Lys Cys Leu Ala Leu Ala Met Leu Trp Ile 
    130                 135                 140                 


Val Gly Ile Leu Thr Ser Arg Gly Val Lys Glu Val Thr Trp Leu Gln 
145                 150                 155                 160 


Ile Ala Ser Ser Val Leu Lys Val Ser Ile Leu Ser Phe Ile Ser Leu 
                165                 170                 175     


Thr Gly Val Val Phe Leu Ile Arg Gly Lys Lys Glu Asn Val Glu Arg 
            180                 185                 190         


Phe Gln Asn Ala Phe Asp Ala Glu Leu Pro Asp Ile Ser His Leu Ile 
        195                 200                 205             


Gln Ala Ile Phe Gln Gly Tyr Phe Ala Tyr Ser Gly Gly Ala Cys Phe 
    210                 215                 220                 


Thr Leu Ile Ala Gly Glu Leu Lys Lys Pro Arg Thr Thr Ile Pro Lys 
225                 230                 235                 240 


Cys Ile Phe Thr Ala Leu Pro Leu Val Thr Val Val Tyr Leu Leu Val 
                245                 250                 255     


Asn Ile Ser Tyr Leu Thr Val Leu Thr Pro Arg Glu Ile Leu Ser Ser 
            260                 265                 270         


Asp Ala Val Ala Ile Thr Trp Ala Asp Arg Ala Phe Pro Ser Leu Ala 
        275                 280                 285             


Trp Ile Met Pro Phe Ala Ile Ser Thr Ser Leu Phe Ser Asn Leu Leu 
    290                 295                 300                 


Ile Ser Ile Phe Lys Ser Ser Arg Pro Ile Tyr Leu Ala Ser Gln Glu 
305                 310                 315                 320 


Gly Gln Leu Pro Leu Leu Phe Asn Thr Leu Asn Ser His Ser Ser Pro 
                325                 330                 335     


Phe Thr Ala Val Leu Leu Leu Val Thr Leu Gly Ser Leu Ala Ile Ile 
            340                 345                 350         


Leu Thr Ser Leu Ile Asp Leu Ile Asn Tyr Ile Phe Phe Thr Gly Ser 
        355                 360                 365             


Leu Trp Ser Ile Leu Leu Met Ile Gly Ile Leu Arg Arg Arg Tyr Gln 
    370                 375                 380                 


Glu Pro Asn Leu Ser Ile Pro Tyr Lys Val Phe Leu Ser Phe Pro Leu 
385                 390                 395                 400 


Ala Thr Ile Val Ile Asp Val Gly Leu Val Val Ile Pro Leu Val Lys 
                405                 410                 415     


Ser Pro Asn Val His Tyr Val Tyr Val Leu Leu Leu Val Leu Ser Gly 
            420                 425                 430         


Leu Leu Phe Tyr Ile Pro Leu Ile His Phe Lys Ile Arg Leu Ala Trp 
        435                 440                 445             


Phe Glu Lys Met Thr Cys Tyr Leu Gln Leu Leu Phe Asn Ile Cys Leu 
    450                 455                 460                 


Pro Asp Val Ser Glu Glu 
465                 470 


<210> 60
<211> 501
<212> PRT
<213> Homo sapiens

<400> 60
Met Val Arg Lys Pro Val Val Ser Thr Ile Ser Lys Gly Gly Tyr Leu 
1               5                   10                  15      


Gln Gly Asn Val Asn Gly Arg Leu Pro Ser Leu Gly Asn Lys Glu Pro 
            20                  25                  30          


Pro Gly Gln Glu Lys Val Gln Leu Lys Arg Lys Val Thr Leu Leu Arg 
        35                  40                  45              


Gly Val Ser Ile Ile Ile Gly Thr Ile Ile Gly Ala Gly Ile Phe Ile 
    50                  55                  60                  


Ser Pro Lys Gly Val Leu Gln Asn Thr Gly Ser Val Gly Met Ser Leu 
65                  70                  75                  80  


Thr Ile Trp Thr Val Cys Gly Val Leu Ser Leu Phe Gly Ala Leu Ser 
                85                  90                  95      


Tyr Ala Glu Leu Gly Thr Thr Ile Lys Lys Ser Gly Gly His Tyr Thr 
            100                 105                 110         


Tyr Ile Leu Glu Val Phe Gly Pro Leu Pro Ala Phe Val Arg Val Trp 
        115                 120                 125             


Val Glu Leu Leu Ile Ile Arg Pro Ala Ala Thr Ala Val Ile Ser Leu 
    130                 135                 140                 


Ala Phe Gly Arg Tyr Ile Leu Glu Pro Phe Phe Ile Gln Cys Glu Ile 
145                 150                 155                 160 


Pro Glu Leu Ala Ile Lys Leu Ile Thr Ala Val Gly Ile Thr Val Val 
                165                 170                 175     


Met Val Leu Asn Ser Met Ser Val Ser Trp Ser Ala Arg Ile Gln Ile 
            180                 185                 190         


Phe Leu Thr Phe Cys Lys Leu Thr Ala Ile Leu Ile Ile Ile Val Pro 
        195                 200                 205             


Gly Val Met Gln Leu Ile Lys Gly Gln Thr Gln Asn Phe Lys Asp Ala 
    210                 215                 220                 


Phe Ser Gly Arg Asp Ser Ser Ile Thr Arg Leu Pro Leu Ala Phe Tyr 
225                 230                 235                 240 


Tyr Gly Met Tyr Ala Tyr Ala Gly Trp Phe Tyr Leu Asn Phe Val Thr 
                245                 250                 255     


Glu Glu Val Glu Asn Pro Glu Lys Thr Ile Pro Leu Ala Ile Cys Ile 
            260                 265                 270         


Ser Met Ala Ile Val Thr Ile Gly Tyr Val Leu Thr Asn Val Ala Tyr 
        275                 280                 285             


Phe Thr Thr Ile Asn Ala Glu Glu Leu Leu Leu Ser Asn Ala Val Ala 
    290                 295                 300                 


Val Thr Phe Ser Glu Arg Leu Leu Gly Asn Phe Ser Leu Ala Val Pro 
305                 310                 315                 320 


Ile Phe Val Ala Leu Ser Cys Phe Gly Ser Met Asn Gly Gly Val Phe 
                325                 330                 335     


Ala Val Ser Arg Leu Phe Tyr Val Ala Ser Arg Glu Gly His Leu Pro 
            340                 345                 350         


Glu Ile Leu Ser Met Ile His Val Arg Lys His Thr Pro Leu Pro Ala 
        355                 360                 365             


Val Ile Val Leu His Pro Leu Thr Met Ile Met Leu Phe Ser Gly Asp 
    370                 375                 380                 


Leu Asp Ser Leu Leu Asn Phe Leu Ser Phe Ala Arg Trp Leu Phe Ile 
385                 390                 395                 400 


Gly Leu Ala Val Ala Gly Leu Ile Tyr Leu Arg Tyr Lys Cys Pro Asp 
                405                 410                 415     


Met His Arg Pro Phe Lys Val Pro Leu Phe Ile Pro Ala Leu Phe Ser 
            420                 425                 430         


Phe Thr Cys Leu Phe Met Val Ala Leu Ser Leu Tyr Ser Asp Pro Phe 
        435                 440                 445             


Ser Thr Gly Ile Gly Phe Val Ile Thr Leu Thr Gly Val Pro Ala Tyr 
    450                 455                 460                 


Tyr Leu Phe Ile Ile Trp Asp Lys Lys Pro Arg Trp Phe Arg Ile Met 
465                 470                 475                 480 


Ser Glu Lys Ile Thr Arg Thr Leu Gln Ile Ile Leu Glu Val Val Pro 
                485                 490                 495     


Glu Glu Asp Lys Leu 
            500     


<210> 61
<211> 602
<212> PRT
<213> Homo sapiens

<400> 61
Met Ala Ala Leu Ala Ala Ala Ala Lys Lys Val Trp Ser Ala Arg Arg 
1               5                   10                  15      


Leu Leu Val Leu Leu Phe Thr Pro Leu Ala Leu Leu Pro Val Val Phe 
            20                  25                  30          


Ala Leu Pro Pro Lys Glu Gly Arg Cys Leu Phe Val Ile Leu Leu Met 
        35                  40                  45              


Ala Val Tyr Trp Cys Thr Glu Ala Leu Pro Leu Ser Val Thr Ala Leu 
    50                  55                  60                  


Leu Pro Ile Val Leu Phe Pro Phe Met Gly Ile Leu Pro Ser Asn Lys 
65                  70                  75                  80  


Val Cys Pro Gln Tyr Phe Leu Asp Thr Asn Phe Leu Phe Leu Ser Gly 
                85                  90                  95      


Leu Ile Met Ala Ser Ala Ile Glu Glu Trp Asn Leu His Arg Arg Ile 
            100                 105                 110         


Ala Leu Lys Ile Leu Met Leu Val Gly Val Gln Pro Ala Arg Leu Ile 
        115                 120                 125             


Leu Gly Met Met Val Thr Thr Ser Phe Leu Ser Met Trp Leu Ser Asn 
    130                 135                 140                 


Thr Ala Ser Thr Ala Met Met Leu Pro Ile Ala Asn Ala Ile Leu Lys 
145                 150                 155                 160 


Ser Leu Phe Gly Gln Lys Glu Val Arg Lys Asp Pro Ser Gln Glu Ser 
                165                 170                 175     


Glu Glu Asn Thr Ala Ala Val Arg Arg Asn Gly Leu His Thr Val Pro 
            180                 185                 190         


Thr Glu Met Gln Phe Leu Ala Ser Thr Glu Ala Lys Asp His Pro Gly 
        195                 200                 205             


Glu Thr Glu Val Pro Leu Asp Leu Pro Ala Asp Ser Arg Lys Glu Asp 
    210                 215                 220                 


Glu Tyr Arg Arg Asn Ile Trp Lys Gly Phe Leu Ile Ser Ile Pro Tyr 
225                 230                 235                 240 


Ser Ala Ser Ile Gly Gly Thr Ala Thr Leu Thr Gly Thr Ala Pro Asn 
                245                 250                 255     


Leu Ile Leu Leu Gly Gln Leu Lys Ser Phe Phe Pro Gln Cys Asp Val 
            260                 265                 270         


Val Asn Phe Gly Ser Trp Phe Ile Phe Ala Phe Pro Leu Met Leu Leu 
        275                 280                 285             


Phe Leu Leu Ala Gly Trp Leu Trp Ile Ser Phe Leu Tyr Gly Gly Leu 
    290                 295                 300                 


Ser Phe Arg Gly Trp Arg Lys Asn Lys Ser Glu Ile Arg Thr Asn Ala 
305                 310                 315                 320 


Glu Asp Arg Ala Arg Ala Val Ile Arg Glu Glu Tyr Gln Asn Leu Gly 
                325                 330                 335     


Pro Ile Lys Phe Ala Glu Gln Ala Val Phe Ile Leu Phe Cys Met Phe 
            340                 345                 350         


Ala Ile Leu Leu Phe Thr Arg Asp Pro Lys Phe Ile Pro Gly Trp Ala 
        355                 360                 365             


Ser Leu Phe Asn Pro Gly Phe Leu Ser Asp Ala Val Thr Gly Val Ala 
    370                 375                 380                 


Ile Val Thr Ile Leu Phe Phe Phe Pro Ser Gln Arg Pro Ser Leu Lys 
385                 390                 395                 400 


Trp Trp Phe Asp Phe Lys Ala Pro Asn Thr Glu Thr Glu Pro Leu Leu 
                405                 410                 415     


Thr Trp Lys Lys Ala Gln Glu Thr Val Pro Trp Asn Ile Ile Leu Leu 
            420                 425                 430         


Leu Gly Gly Gly Phe Ala Met Ala Lys Gly Cys Glu Glu Ser Gly Leu 
        435                 440                 445             


Ser Val Trp Ile Gly Gly Gln Leu His Pro Leu Glu Asn Val Pro Pro 
    450                 455                 460                 


Ala Leu Ala Val Leu Leu Ile Thr Val Val Ile Ala Phe Phe Thr Glu 
465                 470                 475                 480 


Phe Ala Ser Asn Thr Ala Thr Ile Ile Ile Phe Leu Pro Val Leu Ala 
                485                 490                 495     


Glu Leu Ala Ile Arg Leu Arg Val His Pro Leu Tyr Leu Met Ile Pro 
            500                 505                 510         


Gly Thr Val Gly Cys Ser Phe Ala Phe Met Leu Pro Val Ser Thr Pro 
        515                 520                 525             


Pro Asn Ser Ile Ala Phe Ala Ser Gly His Leu Leu Val Lys Asp Met 
    530                 535                 540                 


Val Arg Thr Gly Leu Leu Met Asn Leu Met Gly Val Leu Leu Leu Ser 
545                 550                 555                 560 


Leu Ala Met Asn Thr Trp Ala Gln Thr Ile Phe Gln Leu Gly Thr Phe 
                565                 570                 575     


Pro Asp Trp Ala Asp Met Tyr Ser Val Asn Val Thr Ala Leu Pro Pro 
            580                 585                 590         


Thr Leu Ala Asn Asp Thr Phe Arg Thr Leu 
        595                 600         


<210> 62
<211> 54
<212> DNA
<213> Thosea asigna virus

<400> 62
gagggcagag gaagtcttct aacatgcggt gacgtggagg sgsstcccgg ccct             54


<210> 63
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 64
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 64
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 65
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 65
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 66
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 66
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 67
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 67
Leu Pro Xaa Thr Gly 
1               5   


<210> 68
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 68
Leu Pro Xaa Thr Ala 
1               5   


<210> 69
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 69
Gly Gly Ser Gly Gly Ser Gly Gly 
1               5               


<210> 70
<211> 405
<212> PRT
<213> Pongo abelii

<400> 70
Met Gln Glu Lys Glu Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Glu Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Pro Ser Val Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Val Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Ala Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Met Thr Asp Ile Glu Ala Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Cys 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu Tyr Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu Gln Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Val Glu Leu Pro Ala 
            340                 345                 350         


Val Met Thr His Ala Ser Val Leu Lys Lys Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 71
<211> 405
<212> PRT
<213> Macaca fascicularis

<400> 71
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Glu Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Leu Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Ala Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Val Leu Lys Met Ile Asp Ile Glu Ala Cys Ala His Ile Val 
                165                 170                 175     


His Lys Arg Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Cys 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Arg Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Leu Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Gly Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Ala Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Ile Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Val Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Pro Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Lys 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Asn 
                405 


<210> 72
<211> 405
<212> PRT
<213> Pan troglodytes

<400> 72
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Leu Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Ala Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 73
<211> 405
<212> PRT
<213> Pan paniscus

<400> 73
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Lys Ala Leu Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Ala Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Ile Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 74
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 74
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Asn Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Leu Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 75
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 75
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Asn Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Leu Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 76
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 76
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Leu Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 77
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 77
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Asn Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Ala Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 78
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 78
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Ala Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 79
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 79
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Asn Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Leu Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Asp 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 80
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 80
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Asn Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Leu Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Asp 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 81
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 81
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Leu Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Asp 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 82
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 82
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Asn Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Ala Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Asp 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 83
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 83
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Ala Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Asp 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 84
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 84
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Asn Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Leu Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Glu 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 85
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 85
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Asn Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Leu Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Glu 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 86
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 86
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Leu Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Glu 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 87
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 87
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Asn Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Ala Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Glu 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 88
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 88
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Ala Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Glu 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 89
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 89
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Asp Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 90
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 90
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn His Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 91
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 91
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Gly Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 92
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 92
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Ile Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 93
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 93
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Glu 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 94
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 94
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Ile Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Glu 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 95
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<400> 95
Gly Gly Gly Xaa Xaa Gly Gly Gly Gly Ser 
1               5                   10  


<210> 96
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 96
Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   


<210> 97
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 97
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 98
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 98
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210> 99
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 99
Pro Ser Thr Ser Thr Ser Thr 
1               5           


<210> 100
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 100
Glu Ile Asp Lys Pro Ser Gln 
1               5           


<210> 101
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 101
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala 
            


<210> 102
<211> 131
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 102
Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser Ser Ser Val 
1               5                   10                  15      


Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp 
            20                  25                  30          


Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser Val 
        35                  40                  45              


Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu 
    50                  55                  60                  


Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val 
65                  70                  75                  80  


Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg 
                85                  90                  95      


Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro 
            100                 105                 110         


Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr 
        115                 120                 125             


Ser Asp Gln 
    130     


<210> 103
<211> 78
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 103
Met Gln Pro Gln Glu Ser His Val His Tyr Ser Arg Trp Glu Asp Gly 
1               5                   10                  15      


Ser Arg Asp Gly Val Ser Leu Gly Ala Val Ser Ser Thr Glu Glu Ala 
            20                  25                  30          


Ser Arg Cys Arg Arg Ile Ser Gln Arg Leu Cys Thr Gly Lys Leu Gly 
        35                  40                  45              


Ile Ala Met Lys Val Leu Gly Gly Val Ala Leu Phe Trp Ile Ile Phe 
    50                  55                  60                  


Ile Leu Gly Tyr Leu Thr Gly Tyr Tyr Val His Lys Cys Lys 
65                  70                  75              


<210> 104
<211> 582
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 104
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro 
            20                  25                  30          


His Phe Gln His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro 
        35                  40                  45              


Glu Gln Trp Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr 
    50                  55                  60                  


Thr Phe Lys Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser 
65                  70                  75                  80  


Arg Leu Gly Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala 
                85                  90                  95      


Leu Asp Gly Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala 
            100                 105                 110         


Thr Val Thr Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys 
        115                 120                 125             


Met Asp Asp Val Tyr Gly Gly Thr Asn Ala Tyr Phe Arg Gln Val Ala 
    130                 135                 140                 


Ser Glu Phe Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys 
145                 150                 155                 160 


Leu Leu Glu Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu 
                165                 170                 175     


Thr Pro Thr Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala 
            180                 185                 190         


His Ile Val His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr 
        195                 200                 205             


Phe Met Ser Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile 
    210                 215                 220                 


Ser Met Tyr Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val 
225                 230                 235                 240 


Met Gly Leu Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg 
                245                 250                 255     


Phe Leu Gln Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr 
            260                 265                 270         


Leu Cys Asn Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His 
        275                 280                 285             


Phe Lys Asn Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp 
    290                 295                 300                 


Val Glu Lys Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu 
305                 310                 315                 320 


Leu Val Lys Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr 
                325                 330                 335     


Ile Lys Gly Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys 
            340                 345                 350         


Leu Phe Thr Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu 
        355                 360                 365             


Leu Pro Ala Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp 
    370                 375                 380                 


Val Leu Gly Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu 
385                 390                 395                 400 


Asp Glu Glu Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala 
                405                 410                 415     


His Pro Pro Ser Gly Ser His Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
    450                 455                 460                 


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His 
465                 470                 475                 480 


Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu 
                485                 490                 495     


Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg 
            500                 505                 510         


Val Gln Leu Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile 
        515                 520                 525             


Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr 
    530                 535                 540                 


Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu 
545                 550                 555                 560 


Pro Ser Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn 
                565                 570                 575     


Pro Glu Thr Ser Asp Gln 
            580         


<210> 105
<211> 563
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 105
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Ala Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Tyr Pro 
                405                 410                 415     


Tyr Asp Val Pro Asp Tyr Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            420                 425                 430         


Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser Ser Ser Val 
        435                 440                 445             


Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp 
    450                 455                 460                 


Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser Val 
465                 470                 475                 480 


Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu 
                485                 490                 495     


Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val 
            500                 505                 510         


Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg 
        515                 520                 525             


Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro 
    530                 535                 540                 


Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr 
545                 550                 555                 560 


Ser Asp Gln 
            


<210> 106
<211> 582
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 106
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro 
            20                  25                  30          


His Phe Gln His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro 
        35                  40                  45              


Glu Gln Trp Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr 
    50                  55                  60                  


Thr Phe Lys Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser 
65                  70                  75                  80  


Arg Leu Gly Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala 
                85                  90                  95      


Leu Asp Gly Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala 
            100                 105                 110         


Thr Val Thr Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys 
        115                 120                 125             


Met Asp Asp Val Tyr Gly Gly Thr Asn Asp Tyr Phe Arg Gln Val Ala 
    130                 135                 140                 


Ser Glu Phe Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys 
145                 150                 155                 160 


Leu Leu Glu Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu 
                165                 170                 175     


Thr Pro Thr Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala 
            180                 185                 190         


His Ile Val His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr 
        195                 200                 205             


Phe Met Ser Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile 
    210                 215                 220                 


Ser Met Tyr Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val 
225                 230                 235                 240 


Met Gly Leu Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg 
                245                 250                 255     


Phe Leu Gln Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr 
            260                 265                 270         


Leu Cys Asn Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His 
        275                 280                 285             


Phe Lys Asn Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp 
    290                 295                 300                 


Val Glu Lys Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu 
305                 310                 315                 320 


Leu Val Lys Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr 
                325                 330                 335     


Ile Lys Gly Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys 
            340                 345                 350         


Leu Phe Thr Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu 
        355                 360                 365             


Leu Pro Ala Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp 
    370                 375                 380                 


Val Leu Gly Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu 
385                 390                 395                 400 


Asp Glu Glu Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala 
                405                 410                 415     


His Pro Pro Ser Gly Ser His Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
    450                 455                 460                 


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His 
465                 470                 475                 480 


Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu 
                485                 490                 495     


Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg 
            500                 505                 510         


Val Gln Leu Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile 
        515                 520                 525             


Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr 
    530                 535                 540                 


Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu 
545                 550                 555                 560 


Pro Ser Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn 
                565                 570                 575     


Pro Glu Thr Ser Asp Gln 
            580         


<210> 107
<211> 563
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 107
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Asp Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Tyr Pro 
                405                 410                 415     


Tyr Asp Val Pro Asp Tyr Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            420                 425                 430         


Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser Ser Ser Val 
        435                 440                 445             


Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp 
    450                 455                 460                 


Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser Val 
465                 470                 475                 480 


Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu 
                485                 490                 495     


Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val 
            500                 505                 510         


Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg 
        515                 520                 525             


Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro 
    530                 535                 540                 


Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr 
545                 550                 555                 560 


Ser Asp Gln 
            


<210> 108
<211> 510
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 108
Met Gln Pro Gln Glu Ser His Val His Tyr Ser Arg Trp Glu Asp Gly 
1               5                   10                  15      


Ser Arg Asp Gly Val Ser Leu Gly Ala Val Ser Ser Thr Glu Glu Ala 
            20                  25                  30          


Ser Arg Cys Arg Arg Ile Ser Gln Arg Leu Cys Thr Gly Lys Leu Gly 
        35                  40                  45              


Ile Ala Met Lys Val Leu Gly Gly Val Ala Leu Phe Trp Ile Ile Phe 
    50                  55                  60                  


Ile Leu Gly Tyr Leu Thr Gly Tyr Tyr Val His Lys Cys Lys Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                85                  90                  95      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Met Gln Glu Lys Asp Ala Ser 
            100                 105                 110         


Ser Gln Gly Phe Leu Pro His Phe Gln His Phe Ala Thr Gln Ala Ile 
        115                 120                 125             


His Val Gly Gln Asp Pro Glu Gln Trp Thr Ser Arg Ala Val Val Pro 
    130                 135                 140                 


Pro Ile Ser Leu Ser Thr Thr Phe Lys Gln Gly Ala Pro Gly Gln His 
145                 150                 155                 160 


Ser Gly Phe Ile Tyr Ser Arg Leu Gly Asn Pro Thr Arg Asn Cys Leu 
                165                 170                 175     


Glu Lys Ala Val Ala Ala Leu Asp Gly Ala Lys Tyr Cys Leu Ala Phe 
            180                 185                 190         


Ala Ser Gly Met Ala Ala Thr Val Thr Ile Thr His Leu Leu Lys Ala 
        195                 200                 205             


Gly Asp Gln Ile Ile Cys Met Asp Asp Val Tyr Gly Gly Thr Asn Ala 
    210                 215                 220                 


Tyr Phe Arg Gln Val Ala Ser Glu Phe Gly Leu Lys Ile Ser Phe Val 
225                 230                 235                 240 


Asp Cys Ser Lys Ile Lys Leu Leu Glu Ala Ala Ile Thr Pro Glu Thr 
                245                 250                 255     


Lys Leu Val Trp Ile Glu Thr Pro Thr Asn Pro Thr Gln Lys Val Ile 
            260                 265                 270         


Asp Ile Glu Gly Cys Ala His Ile Val His Lys His Gly Asp Ile Ile 
        275                 280                 285             


Leu Val Val Asp Asn Thr Phe Met Ser Pro Tyr Phe Gln Arg Pro Leu 
    290                 295                 300                 


Ala Leu Gly Ala Asp Ile Ser Met Tyr Ser Ala Thr Lys Tyr Met Asn 
305                 310                 315                 320 


Gly His Ser Asp Val Val Met Gly Leu Val Ser Val Asn Cys Glu Ser 
                325                 330                 335     


Leu His Asn Arg Leu Arg Phe Leu Gln Asn Ser Leu Gly Ala Val Pro 
            340                 345                 350         


Ser Pro Ile Asp Cys Tyr Leu Cys Asn Arg Gly Leu Lys Thr Leu His 
        355                 360                 365             


Val Arg Met Glu Arg His Phe Lys Asn Gly Met Ala Val Ala Gln Phe 
    370                 375                 380                 


Leu Glu Ser Asn Pro Trp Val Glu Lys Val Ile Tyr Pro Gly Leu Pro 
385                 390                 395                 400 


Ser His Pro Gln His Glu Leu Val Lys Arg Gln Cys Thr Gly Cys Gly 
                405                 410                 415     


Gly Met Val Thr Phe Tyr Ile Lys Gly Thr Leu Gln His Ala Glu Ile 
            420                 425                 430         


Phe Leu Lys Asn Leu Lys Leu Phe Thr Leu Ala Val Ser Leu Gly Gly 
        435                 440                 445             


Phe Glu Ser Leu Ala Glu Leu Pro Ala Ser Met Thr His Ala Ser Val 
    450                 455                 460                 


Leu Lys Asn Asp Arg Asp Val Leu Gly Ile Ser Asp Thr Leu Ile Arg 
465                 470                 475                 480 


Leu Ser Val Gly Leu Glu Asp Glu Glu Asp Leu Leu Glu Asp Leu Asp 
                485                 490                 495     


Gln Ala Leu Lys Ala Ala His Pro Pro Ser Gly Ser His Ser 
            500                 505                 510 


<210> 109
<211> 510
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 109
Met Gln Pro Gln Glu Ser His Val His Tyr Ser Arg Trp Glu Asp Gly 
1               5                   10                  15      


Ser Arg Asp Gly Val Ser Leu Gly Ala Val Ser Ser Thr Glu Glu Ala 
            20                  25                  30          


Ser Arg Cys Arg Arg Ile Ser Gln Arg Leu Cys Thr Gly Lys Leu Gly 
        35                  40                  45              


Ile Ala Met Lys Val Leu Gly Gly Val Ala Leu Phe Trp Ile Ile Phe 
    50                  55                  60                  


Ile Leu Gly Tyr Leu Thr Gly Tyr Tyr Val His Lys Cys Lys Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                85                  90                  95      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Met Gln Glu Lys Asp Ala Ser 
            100                 105                 110         


Ser Gln Gly Phe Leu Pro His Phe Gln His Phe Ala Thr Gln Ala Ile 
        115                 120                 125             


His Val Gly Gln Asp Pro Glu Gln Trp Thr Ser Arg Ala Val Val Pro 
    130                 135                 140                 


Pro Ile Ser Leu Ser Thr Thr Phe Lys Gln Gly Ala Pro Gly Gln His 
145                 150                 155                 160 


Ser Gly Phe Ile Tyr Ser Arg Leu Gly Asn Pro Thr Arg Asn Cys Leu 
                165                 170                 175     


Glu Lys Ala Val Ala Ala Leu Asp Gly Ala Lys Tyr Cys Leu Ala Phe 
            180                 185                 190         


Ala Ser Gly Met Ala Ala Thr Val Thr Ile Thr His Leu Leu Lys Ala 
        195                 200                 205             


Gly Asp Gln Ile Ile Cys Met Asp Asp Val Tyr Gly Gly Thr Asn Asp 
    210                 215                 220                 


Tyr Phe Arg Gln Val Ala Ser Glu Phe Gly Leu Lys Ile Ser Phe Val 
225                 230                 235                 240 


Asp Cys Ser Lys Ile Lys Leu Leu Glu Ala Ala Ile Thr Pro Glu Thr 
                245                 250                 255     


Lys Leu Val Trp Ile Glu Thr Pro Thr Asn Pro Thr Gln Lys Val Ile 
            260                 265                 270         


Asp Ile Glu Gly Cys Ala His Ile Val His Lys His Gly Asp Ile Ile 
        275                 280                 285             


Leu Val Val Asp Asn Thr Phe Met Ser Pro Tyr Phe Gln Arg Pro Leu 
    290                 295                 300                 


Ala Leu Gly Ala Asp Ile Ser Met Tyr Ser Ala Thr Lys Tyr Met Asn 
305                 310                 315                 320 


Gly His Ser Asp Val Val Met Gly Leu Val Ser Val Asn Cys Glu Ser 
                325                 330                 335     


Leu His Asn Arg Leu Arg Phe Leu Gln Asn Ser Leu Gly Ala Val Pro 
            340                 345                 350         


Ser Pro Ile Asp Cys Tyr Leu Cys Asn Arg Gly Leu Lys Thr Leu His 
        355                 360                 365             


Val Arg Met Glu Arg His Phe Lys Asn Gly Met Ala Val Ala Gln Phe 
    370                 375                 380                 


Leu Glu Ser Asn Pro Trp Val Glu Lys Val Ile Tyr Pro Gly Leu Pro 
385                 390                 395                 400 


Ser His Pro Gln His Glu Leu Val Lys Arg Gln Cys Thr Gly Cys Gly 
                405                 410                 415     


Gly Met Val Thr Phe Tyr Ile Lys Gly Thr Leu Gln His Ala Glu Ile 
            420                 425                 430         


Phe Leu Lys Asn Leu Lys Leu Phe Thr Leu Ala Val Ser Leu Gly Gly 
        435                 440                 445             


Phe Glu Ser Leu Ala Glu Leu Pro Ala Ser Met Thr His Ala Ser Val 
    450                 455                 460                 


Leu Lys Asn Asp Arg Asp Val Leu Gly Ile Ser Asp Thr Leu Ile Arg 
465                 470                 475                 480 


Leu Ser Val Gly Leu Glu Asp Glu Glu Asp Leu Leu Glu Asp Leu Asp 
                485                 490                 495     


Gln Ala Leu Lys Ala Ala His Pro Pro Ser Gly Ser His Ser 
            500                 505                 510 


<210> 110
<211> 421
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 110
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser Gly Gly Gly Ser Gly Gly Gly Tyr Pro Tyr Asp 
                405                 410                 415     


Val Pro Asp Tyr Ala 
            420     


<210> 111
<211> 421
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 111
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Ala Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser Gly Gly Gly Ser Gly Gly Gly Tyr Pro Tyr Asp 
                405                 410                 415     


Val Pro Asp Tyr Ala 
            420     


<210> 112
<211> 421
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 112
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Ile Tyr Ser Arg Leu Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Met Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Asp Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Arg His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Gly Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ser Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser Gly Gly Gly Ser Gly Gly Gly Tyr Pro Tyr Asp 
                405                 410                 415     


Val Pro Asp Tyr Ala 
            420     


