                               SEQUENCE LISTING

<110> REFUGE BIOTECHNOLOGIES, INC.
 
<120> GENE REGULATION VIA CONDITIONAL NUCLEAR LOCALIZATION OF GENE 
      MODULATING POLYPEPTIDES

<130> 50489-711.601

<140>
<141>

<150> 62/675,134
<151> 2018-05-22

<150> 62/647,543
<151> 2018-03-23

<160> 40    

<170> PatentIn version 3.5

<210> 1
<211> 1839
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Asn Ala Pro Glu Arg Gln Pro Gln Pro Asp Gly Gly Asp Ala Pro 
1               5                   10                  15      


Gly His Glu Pro Gly Gly Ser Pro Gln Asp Glu Leu Asp Phe Ser Ile 
            20                  25                  30          


Leu Phe Asp Tyr Glu Tyr Leu Asn Pro Asn Glu Glu Glu Pro Asn Ala 
        35                  40                  45              


His Lys Val Ala Ser Pro Pro Ser Gly Pro Ala Tyr Pro Asp Asp Val 
    50                  55                  60                  


Leu Asp Tyr Gly Leu Lys Pro Tyr Ser Pro Leu Ala Ser Leu Ser Gly 
65                  70                  75                  80  


Glu Pro Pro Gly Arg Phe Gly Glu Pro Asp Arg Val Gly Pro Gln Lys 
                85                  90                  95      


Phe Leu Ser Ala Ala Lys Pro Ala Gly Ala Ser Gly Leu Ser Pro Arg 
            100                 105                 110         


Ile Glu Ile Thr Pro Ser His Glu Leu Ile Gln Ala Val Gly Pro Leu 
        115                 120                 125             


Arg Met Arg Asp Ala Gly Leu Leu Val Glu Gln Pro Pro Leu Ala Gly 
    130                 135                 140                 


Val Ala Ala Ser Pro Arg Phe Thr Leu Pro Val Pro Gly Phe Glu Gly 
145                 150                 155                 160 


Tyr Arg Glu Pro Leu Cys Leu Ser Pro Ala Ser Ser Gly Ser Ser Ala 
                165                 170                 175     


Ser Phe Ile Ser Asp Thr Phe Ser Pro Tyr Thr Ser Pro Cys Val Ser 
            180                 185                 190         


Pro Asn Asn Gly Gly Pro Asp Asp Leu Cys Pro Gln Phe Gln Asn Ile 
        195                 200                 205             


Pro Ala His Tyr Ser Pro Arg Thr Ser Pro Ile Met Ser Pro Arg Thr 
    210                 215                 220                 


Ser Leu Ala Glu Asp Ser Cys Leu Gly Arg His Ser Pro Val Pro Arg 
225                 230                 235                 240 


Pro Ala Ser Arg Ser Ser Ser Pro Gly Ala Lys Arg Arg His Ser Cys 
                245                 250                 255     


Ala Glu Ala Leu Val Ala Leu Pro Pro Gly Ala Ser Pro Gln Arg Ser 
            260                 265                 270         


Arg Ser Pro Ser Pro Gln Pro Ser Ser His Val Ala Pro Gln Asp His 
        275                 280                 285             


Gly Ser Pro Ala Gly Tyr Pro Pro Val Ala Gly Ser Ala Val Ile Met 
    290                 295                 300                 


Asp Ala Leu Asn Ser Leu Ala Thr Asp Ser Pro Cys Gly Ile Pro Pro 
305                 310                 315                 320 


Lys Met Trp Lys Thr Ser Pro Asp Pro Ser Pro Val Ser Ala Ala Pro 
                325                 330                 335     


Ser Lys Ala Gly Leu Pro Arg His Ile Tyr Pro Ala Val Glu Phe Leu 
            340                 345                 350         


Gly Pro Cys Glu Gln Gly Glu Arg Arg Asn Ser Ala Pro Glu Ser Ile 
        355                 360                 365             


Leu Leu Val Pro Pro Thr Trp Pro Lys Pro Leu Val Pro Ala Ile Pro 
    370                 375                 380                 


Ile Cys Ser Ile Pro Val Thr Thr Ser Asp Lys Lys Tyr Ser Ile Gly 
385                 390                 395                 400 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
                405                 410                 415     


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
            420                 425                 430         


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
        435                 440                 445             


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
    450                 455                 460                 


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
465                 470                 475                 480 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
                485                 490                 495     


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
            500                 505                 510         


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
        515                 520                 525             


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
    530                 535                 540                 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
545                 550                 555                 560 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
                565                 570                 575     


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
            580                 585                 590         


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
        595                 600                 605             


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
    610                 615                 620                 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
625                 630                 635                 640 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
                645                 650                 655     


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
            660                 665                 670         


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
        675                 680                 685             


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
    690                 695                 700                 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
705                 710                 715                 720 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
                725                 730                 735     


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
            740                 745                 750         


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
        755                 760                 765             


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
    770                 775                 780                 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
785                 790                 795                 800 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
                805                 810                 815     


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
            820                 825                 830         


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
        835                 840                 845             


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
    850                 855                 860                 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
865                 870                 875                 880 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
                885                 890                 895     


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
            900                 905                 910         


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
        915                 920                 925             


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
    930                 935                 940                 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
945                 950                 955                 960 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
                965                 970                 975     


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
            980                 985                 990         


Ile Lys Asp Lys Asp Phe Leu Asp  Asn Glu Glu Asn Glu  Asp Ile Leu 
        995                 1000                 1005             


Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe Glu Asp  Arg Glu Met 
    1010                 1015                 1020             


Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His Leu Phe  Asp Asp Lys 
    1025                 1030                 1035             


Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr Thr Gly  Trp Gly Arg 
    1040                 1045                 1050             


Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg Asp Lys  Gln Ser Gly 
    1055                 1060                 1065             


Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp Gly Phe  Ala Asn Arg 
    1070                 1075                 1080             


Asn Phe  Met Gln Leu Ile His  Asp Asp Ser Leu Thr  Phe Lys Glu 
    1085                 1090                 1095             


Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln Gly Asp  Ser Leu His 
    1100                 1105                 1110             


Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro Ala Ile  Lys Lys Gly 
    1115                 1120                 1125             


Ile Leu  Gln Thr Val Lys Val  Val Asp Glu Leu Val  Lys Val Met 
    1130                 1135                 1140             


Gly Arg  His Lys Pro Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu 
    1145                 1150                 1155             


Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met 
    1160                 1165                 1170             


Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu 
    1175                 1180                 1185             


Lys Glu  His Pro Val Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu 
    1190                 1195                 1200             


Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
    1205                 1210                 1215             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp Ala Ile 
    1220                 1225                 1230             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1235                 1240                 1245             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1250                 1255                 1260             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1265                 1270                 1275             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1280                 1285                 1290             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1295                 1300                 1305             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1310                 1315                 1320             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1325                 1330                 1335             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1340                 1345                 1350             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1355                 1360                 1365             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1370                 1375                 1380             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1385                 1390                 1395             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1400                 1405                 1410             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1415                 1420                 1425             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1430                 1435                 1440             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1445                 1450                 1455             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1460                 1465                 1470             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1475                 1480                 1485             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1490                 1495                 1500             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1505                 1510                 1515             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1520                 1525                 1530             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1535                 1540                 1545             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1550                 1555                 1560             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1565                 1570                 1575             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1580                 1585                 1590             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1595                 1600                 1605             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1610                 1615                 1620             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1625                 1630                 1635             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1640                 1645                 1650             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1655                 1660                 1665             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1670                 1675                 1680             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1685                 1690                 1695             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1700                 1705                 1710             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1715                 1720                 1725             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1730                 1735                 1740             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1745                 1750                 1755             


Gly Asp  Ala Tyr Pro Tyr Asp  Val Pro Asp Tyr Ala  Ser Leu Gly 
    1760                 1765                 1770             


Ser Gly  Asp Gly Ile Gly Ser  Gly Ser Asn Gly Ser  Ser Leu Asp 
    1775                 1780                 1785             


Ala Leu  Asp Asp Phe Asp Leu  Asp Met Leu Gly Ser  Asp Ala Leu 
    1790                 1795                 1800             


Asp Asp  Phe Asp Leu Asp Met  Leu Gly Ser Asp Ala  Leu Asp Asp 
    1805                 1810                 1815             


Phe Asp  Leu Asp Met Leu Gly  Ser Asp Ala Leu Asp  Asp Phe Asp 
    1820                 1825                 1830             


Leu Asp  Met Leu Gly Ser 
    1835                 


<210> 2
<211> 7
<212> PRT
<213> Simian virus 40

<400> 2
Pro Lys Lys Lys Arg Lys Val 
1               5           


<210> 3
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Nucleoplasmin bipartite NLS sequence

<400> 3
Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210> 4
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      C-myc NLS sequence

<400> 4
Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210> 5
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      C-myc NLS sequence

<400> 5
Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210> 6
<211> 38
<212> PRT
<213> Homo sapiens

<400> 6
Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210> 7
<211> 42
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      IBB domain from importin-alpha sequence

<400> 7
Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210> 8
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Myoma T protein sequence

<400> 8
Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210> 9
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Myoma T protein sequence

<400> 9
Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210> 10
<211> 8
<212> PRT
<213> Homo sapiens

<400> 10
Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210> 11
<211> 12
<212> PRT
<213> Mus musculus

<400> 11
Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210> 12
<211> 5
<212> PRT
<213> Influenza virus

<400> 12
Asp Arg Leu Arg Arg 
1               5   


<210> 13
<211> 7
<212> PRT
<213> Influenza virus

<400> 13
Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210> 14
<211> 10
<212> PRT
<213> Hepatitis delta virus

<400> 14
Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210> 15
<211> 10
<212> PRT
<213> Mus musculus

<400> 15
Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210> 16
<211> 20
<212> PRT
<213> Homo sapiens

<400> 16
Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210> 17
<211> 17
<212> PRT
<213> Homo sapiens

<400> 17
Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210> 18
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Dual acylation region sequence


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<400> 18
Met Gly Cys Xaa Cys 
1               5   


<210> 19
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Glu Thr Gln Arg Cys Thr Trp His Met Gly Glu Leu Val Trp Cys Glu 
1               5                   10                  15      


Arg Glu His Asn 
            20  


<210> 20
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Lys Glu Ala Ser Cys Ser Tyr Trp Leu Gly Glu Leu Val Trp Cys Val 
1               5                   10                  15      


Ala Gly Val Glu 
            20  


<210> 21
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210> 22
<211> 142
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Leu Ala Thr Thr Leu Glu Arg Ile Glu Lys Asn Phe Val Ile Thr Asp 
1               5                   10                  15      


Pro Arg Leu Pro Asp Asn Pro Ile Ile Phe Ala Ser Asp Ser Phe Leu 
            20                  25                  30          


Gln Leu Thr Glu Tyr Ser Arg Glu Glu Ile Leu Gly Arg Asn Cys Arg 
        35                  40                  45              


Phe Leu Gln Gly Pro Glu Thr Asp Arg Ala Thr Val Arg Lys Ile Arg 
    50                  55                  60                  


Asp Ala Ile Asp Asn Gln Thr Glu Val Thr Val Gln Leu Ile Asn Tyr 
65                  70                  75                  80  


Thr Lys Ser Gly Lys Lys Phe Trp Asn Leu Phe His Leu Gln Pro Met 
                85                  90                  95      


Arg Asp Gln Lys Gly Asp Val Gln Tyr Phe Ile Gly Val Gln Leu Asp 
            100                 105                 110         


Gly Thr Glu His Val Arg Asp Ala Ala Glu Arg Glu Gly Val Met Leu 
        115                 120                 125             


Ile Lys Lys Thr Ala Glu Asn Ile Asp Glu Ala Ala Lys Glu 
    130                 135                 140         


<210> 23
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Leu Ala Thr Thr Leu Glu Arg Ile Glu Lys Asn Phe Val Ile Thr 
1               5                   10                  15      


Asp Pro Arg Leu Pro Asp Asn Pro Ile Ile Phe Ala Ser Asp Ser Phe 
            20                  25                  30          


Leu Gln Leu Thr Glu Tyr Ser Arg Glu Glu Ile Leu Gly Arg Asn Cys 
        35                  40                  45              


Arg Phe Leu Gln Gly Pro Glu Thr Asp Arg Ala Thr Val Arg Lys Ile 
    50                  55                  60                  


Arg Asp Ala Ile Asp Asn Gln Thr Glu Val Thr Val Gln Leu Ile Asn 
65                  70                  75                  80  


Tyr Thr Lys Ser Gly Lys Lys Phe Trp Asn Leu Phe His Leu Gln Pro 
                85                  90                  95      


Met Arg Asp Gln Lys Gly Asp Val Gln Tyr Phe Ile Gly Val Gln Leu 
            100                 105                 110         


Asp Gly Thr Glu His Val Arg Asp Ala Ala Glu Arg Glu Gly Val Met 
        115                 120                 125             


Leu Ile Lys Lys Thr Ala Glu Asn Ile Asp Glu Ala Ala 
    130                 135                 140     


<210> 24
<211> 140
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Leu Ala Thr Thr Leu Glu Arg Ile Glu Lys Asn Phe Val Ile Thr Asp 
1               5                   10                  15      


Pro Arg Leu Pro Asp Asn Pro Ile Ile Phe Ala Ser Asp Ser Phe Leu 
            20                  25                  30          


Gln Leu Thr Glu Tyr Ser Arg Glu Glu Ile Leu Gly Arg Asn Cys Arg 
        35                  40                  45              


Phe Leu Gln Gly Pro Glu Thr Asp Arg Ala Thr Val Arg Lys Ile Arg 
    50                  55                  60                  


Asp Ala Ile Asp Asn Gln Thr Glu Val Thr Val Gln Leu Ile Asn Tyr 
65                  70                  75                  80  


Thr Lys Ser Gly Lys Lys Phe Trp Asn Leu Phe His Leu Gln Pro Met 
                85                  90                  95      


Arg Asp Gln Lys Gly Asp Val Gln Tyr Phe Ile Gly Val Gln Leu Asp 
            100                 105                 110         


Gly Thr Glu His Val Arg Asp Ala Ala Glu Arg Glu Gly Val Met Leu 
        115                 120                 125             


Ile Lys Lys Thr Ala Glu Asn Ile Asp Glu Ala Ala 
    130                 135                 140 


<210> 25
<211> 103
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Leu Gln Lys Trp Leu Gln Leu Thr His Glu Val Glu Val Gln Tyr 
1               5                   10                  15      


Tyr Asn Ile Lys Lys Gln Asn Ala Glu Arg Gln Leu Gln Val Ala Lys 
            20                  25                  30          


Glu Gly Ala Glu Lys Ile Lys Lys Lys Arg Asn Thr Leu Phe Gly Thr 
        35                  40                  45              


Phe His Val Ala His Ser Ser Ser Leu Asp Asp Val Asp His Lys Ile 
    50                  55                  60                  


Leu Ala Ala Lys Gln Ala Leu Gly Glu Val Thr Ala Ala Leu Arg Glu 
65                  70                  75                  80  


Arg Leu His Arg Trp Gln Gln Ile Glu Leu Leu Thr Gly Phe Thr Leu 
                85                  90                  95      


Val His Asn Pro Gly Leu Pro 
            100             


<210> 26
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(50)
<223> This sequence may encompass 3-50 residues

<400> 26
Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            20                  25                  30          


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
        35                  40                  45              


Arg Arg 
    50  


<210> 27
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 28
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Glu Glu Glu Glu Glu Glu Glu Glu Glu 
1               5                   


<210> 29
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Gly Gly Gly Gly Ser 
1               5   


<210> 30
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Gly Gly Ser Gly 
1               


<210> 31
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Ser Gly Gly Gly 
1               


<210> 32
<211> 16
<212> PRT
<213> Drosophila melanogaster

<400> 32
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210> 34
<211> 1447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Ala Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala Ser Leu  Gly Ser Gly 
    1370                 1375                 1380             


Asp Gly  Ile Gly Ser Gly Ser  Asn Gly Ser Ser Leu  Asp Ala Leu 
    1385                 1390                 1395             


Asp Asp  Phe Asp Leu Asp Met  Leu Gly Ser Asp Ala  Leu Asp Asp 
    1400                 1405                 1410             


Phe Asp  Leu Asp Met Leu Gly  Ser Asp Ala Leu Asp  Asp Phe Asp 
    1415                 1420                 1425             


Leu Asp  Met Leu Gly Ser Asp  Ala Leu Asp Asp Phe  Asp Leu Asp 
    1430                 1435                 1440             


Met Leu  Gly Ser 
    1445         


<210> 35
<211> 2340
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Asn Ala Pro Glu Arg Gln Pro Gln Pro Asp Gly Gly Asp Ala Pro 
1               5                   10                  15      


Gly His Glu Pro Gly Gly Ser Pro Gln Asp Glu Leu Asp Phe Ser Ile 
            20                  25                  30          


Leu Phe Asp Tyr Glu Tyr Leu Asn Pro Asn Glu Glu Glu Pro Asn Ala 
        35                  40                  45              


His Lys Val Ala Ser Pro Pro Ser Gly Pro Ala Tyr Pro Asp Asp Val 
    50                  55                  60                  


Leu Asp Tyr Gly Leu Lys Pro Tyr Ser Pro Leu Ala Ser Leu Ser Gly 
65                  70                  75                  80  


Glu Pro Pro Gly Arg Phe Gly Glu Pro Asp Arg Val Gly Pro Gln Lys 
                85                  90                  95      


Phe Leu Ser Ala Ala Lys Pro Ala Gly Ala Ser Gly Leu Ser Pro Arg 
            100                 105                 110         


Ile Glu Ile Thr Pro Ser His Glu Leu Ile Gln Ala Val Gly Pro Leu 
        115                 120                 125             


Arg Met Arg Asp Ala Gly Leu Leu Val Glu Gln Pro Pro Leu Ala Gly 
    130                 135                 140                 


Val Ala Ala Ser Pro Arg Phe Thr Leu Pro Val Pro Gly Phe Glu Gly 
145                 150                 155                 160 


Tyr Arg Glu Pro Leu Cys Leu Ser Pro Ala Ser Ser Gly Ser Ser Ala 
                165                 170                 175     


Ser Phe Ile Ser Asp Thr Phe Ser Pro Tyr Thr Ser Pro Cys Val Ser 
            180                 185                 190         


Pro Asn Asn Gly Gly Pro Asp Asp Leu Cys Pro Gln Phe Gln Asn Ile 
        195                 200                 205             


Pro Ala His Tyr Ser Pro Arg Thr Ser Pro Ile Met Ser Pro Arg Thr 
    210                 215                 220                 


Ser Leu Ala Glu Asp Ser Cys Leu Gly Arg His Ser Pro Val Pro Arg 
225                 230                 235                 240 


Pro Ala Ser Arg Ser Ser Ser Pro Gly Ala Lys Arg Arg His Ser Cys 
                245                 250                 255     


Ala Glu Ala Leu Val Ala Leu Pro Pro Gly Ala Ser Pro Gln Arg Ser 
            260                 265                 270         


Arg Ser Pro Ser Pro Gln Pro Ser Ser His Val Ala Pro Gln Asp His 
        275                 280                 285             


Gly Ser Pro Ala Gly Tyr Pro Pro Val Ala Gly Ser Ala Val Ile Met 
    290                 295                 300                 


Asp Ala Leu Asn Ser Leu Ala Thr Asp Ser Pro Cys Gly Ile Pro Pro 
305                 310                 315                 320 


Lys Met Trp Lys Thr Ser Pro Asp Pro Ser Pro Val Ser Ala Ala Pro 
                325                 330                 335     


Ser Lys Ala Gly Leu Pro Arg His Ile Tyr Pro Ala Val Glu Phe Leu 
            340                 345                 350         


Gly Pro Cys Glu Gln Gly Glu Arg Arg Asn Ser Ala Pro Glu Ser Ile 
        355                 360                 365             


Leu Leu Val Pro Pro Thr Trp Pro Lys Pro Leu Val Pro Ala Ile Pro 
    370                 375                 380                 


Ile Cys Ser Ile Pro Val Thr Ala Ser Leu Pro Pro Leu Glu Trp Pro 
385                 390                 395                 400 


Leu Ser Ser Gln Ser Gly Ser Tyr Glu Leu Arg Ile Glu Val Gln Pro 
                405                 410                 415     


Lys Pro His His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala 
            420                 425                 430         


Val Lys Ala Pro Thr Gly Gly His Pro Val Val Gln Leu His Gly Tyr 
        435                 440                 445             


Met Glu Asn Lys Pro Leu Gly Leu Gln Ile Phe Ile Gly Thr Ala Asp 
    450                 455                 460                 


Glu Arg Ile Leu Lys Pro His Ala Phe Tyr Gln Val His Arg Ile Thr 
465                 470                 475                 480 


Gly Lys Thr Val Thr Thr Thr Ser Tyr Glu Lys Ile Val Gly Asn Thr 
                485                 490                 495     


Lys Val Leu Glu Ile Pro Leu Glu Pro Lys Asn Asn Met Arg Ala Thr 
            500                 505                 510         


Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ala Asp Ile Glu Leu 
        515                 520                 525             


Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu 
    530                 535                 540                 


Val Phe Arg Val His Ile Pro Glu Ser Ser Gly Arg Ile Val Ser Leu 
545                 550                 555                 560 


Gln Thr Ala Ser Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala His Glu 
                565                 570                 575     


Leu Pro Met Val Glu Arg Gln Asp Thr Asp Ser Cys Leu Val Tyr Gly 
            580                 585                 590         


Gly Gln Gln Met Ile Leu Thr Gly Gln Asn Phe Thr Ser Glu Ser Lys 
        595                 600                 605             


Val Val Phe Thr Glu Lys Thr Thr Asp Gly Gln Gln Ile Trp Glu Met 
    610                 615                 620                 


Glu Ala Thr Val Asp Lys Asp Lys Ser Gln Pro Asn Met Leu Phe Val 
625                 630                 635                 640 


Glu Ile Pro Glu Tyr Arg Asn Lys His Ile Arg Thr Pro Val Lys Val 
                645                 650                 655     


Asn Phe Tyr Val Ile Asn Gly Lys Arg Lys Arg Ser Gln Pro Gln His 
            660                 665                 670         


Phe Thr Tyr His Pro Val Pro Ala Ile Lys Thr Glu Pro Thr Asp Glu 
        675                 680                 685             


Tyr Asp Pro Thr Leu Ile Cys Ser Pro Thr His Gly Gly Leu Gly Ser 
    690                 695                 700                 


Gln Pro Tyr Tyr Pro Gln His Pro Met Val Ala Glu Ser Pro Ser Cys 
705                 710                 715                 720 


Leu Val Ala Thr Met Ala Pro Cys Gln Gln Phe Arg Thr Gly Leu Ser 
                725                 730                 735     


Ser Pro Asp Ala Arg Tyr Gln Gln Gln Asn Pro Ala Ala Val Leu Tyr 
            740                 745                 750         


Gln Arg Ser Lys Ser Leu Ser Pro Ser Leu Leu Gly Tyr Gln Gln Pro 
        755                 760                 765             


Ala Leu Met Ala Ala Pro Leu Ser Leu Ala Asp Ala His Arg Ser Val 
    770                 775                 780                 


Leu Val His Ala Gly Ser Gln Gly Gln Ser Ser Ala Leu Leu His Pro 
785                 790                 795                 800 


Ser Pro Thr Asn Gln Gln Ala Ser Pro Val Ile His Tyr Ser Pro Thr 
                805                 810                 815     


Asn Gln Gln Leu Arg Cys Gly Ser His Gln Glu Phe Gln His Ile Met 
            820                 825                 830         


Tyr Cys Glu Asn Phe Ala Pro Gly Thr Thr Arg Pro Gly Pro Pro Pro 
        835                 840                 845             


Val Ser Gln Gly Gln Arg Leu Ser Pro Gly Ser Tyr Pro Thr Val Ile 
    850                 855                 860                 


Gln Gln Gln Asn Ala Thr Ser Gln Arg Ala Ala Lys Asn Gly Pro Pro 
865                 870                 875                 880 


Val Ser Asp Gln Lys Glu Val Leu Pro Ala Gly Val Thr Ile Lys Gln 
                885                 890                 895     


Glu Gln Asn Leu Asp Gln Thr Tyr Leu Asp Asp Val Asn Glu Ile Ile 
            900                 905                 910         


Arg Lys Glu Phe Ser Gly Pro Pro Ala Arg Asn Gln Thr Thr Ser Asp 
        915                 920                 925             


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
    930                 935                 940                 


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
945                 950                 955                 960 


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
                965                 970                 975     


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
            980                 985                 990         


Thr Ala Arg Arg Arg Tyr Thr Arg  Arg Lys Asn Arg Ile  Cys Tyr Leu 
        995                 1000                 1005             


Gln Glu  Ile Phe Ser Asn Glu  Met Ala Lys Val Asp  Asp Ser Phe 
    1010                 1015                 1020             


Phe His  Arg Leu Glu Glu Ser  Phe Leu Val Glu Glu  Asp Lys Lys 
    1025                 1030                 1035             


His Glu  Arg His Pro Ile Phe  Gly Asn Ile Val Asp  Glu Val Ala 
    1040                 1045                 1050             


Tyr His  Glu Lys Tyr Pro Thr  Ile Tyr His Leu Arg  Lys Lys Leu 
    1055                 1060                 1065             


Val Asp  Ser Thr Asp Lys Ala  Asp Leu Arg Leu Ile  Tyr Leu Ala 
    1070                 1075                 1080             


Leu Ala  His Met Ile Lys Phe  Arg Gly His Phe Leu  Ile Glu Gly 
    1085                 1090                 1095             


Asp Leu  Asn Pro Asp Asn Ser  Asp Val Asp Lys Leu  Phe Ile Gln 
    1100                 1105                 1110             


Leu Val  Gln Thr Tyr Asn Gln  Leu Phe Glu Glu Asn  Pro Ile Asn 
    1115                 1120                 1125             


Ala Ser  Gly Val Asp Ala Lys  Ala Ile Leu Ser Ala  Arg Leu Ser 
    1130                 1135                 1140             


Lys Ser  Arg Arg Leu Glu Asn  Leu Ile Ala Gln Leu  Pro Gly Glu 
    1145                 1150                 1155             


Lys Lys  Asn Gly Leu Phe Gly  Asn Leu Ile Ala Leu  Ser Leu Gly 
    1160                 1165                 1170             


Leu Thr  Pro Asn Phe Lys Ser  Asn Phe Asp Leu Ala  Glu Asp Ala 
    1175                 1180                 1185             


Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp Asp Asp  Leu Asp Asn 
    1190                 1195                 1200             


Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala Asp Leu  Phe Leu Ala 
    1205                 1210                 1215             


Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu Ser Asp  Ile Leu Arg 
    1220                 1225                 1230             


Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu Ser Ala  Ser Met Ile 
    1235                 1240                 1245             


Lys Arg  Tyr Asp Glu His His  Gln Asp Leu Thr Leu  Leu Lys Ala 
    1250                 1255                 1260             


Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr Lys Glu  Ile Phe Phe 
    1265                 1270                 1275             


Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr Ile Asp  Gly Gly Ala 
    1280                 1285                 1290             


Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys Pro Ile  Leu Glu Lys 
    1295                 1300                 1305             


Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys Leu Asn  Arg Glu Asp 
    1310                 1315                 1320             


Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn Gly Ser  Ile Pro His 
    1325                 1330                 1335             


Gln Ile  His Leu Gly Glu Leu  His Ala Ile Leu Arg  Arg Gln Glu 
    1340                 1345                 1350             


Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg Glu Lys  Ile Glu Lys 
    1355                 1360                 1365             


Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val Gly Pro  Leu Ala Arg 
    1370                 1375                 1380             


Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg Lys Ser  Glu Glu Thr 
    1385                 1390                 1395             


Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val Asp Lys  Gly Ala Ser 
    1400                 1405                 1410             


Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn Phe Asp  Lys Asn Leu 
    1415                 1420                 1425             


Pro Asn  Glu Lys Val Leu Pro  Lys His Ser Leu Leu  Tyr Glu Tyr 
    1430                 1435                 1440             


Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val Lys Tyr  Val Thr Glu 
    1445                 1450                 1455             


Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly Glu Gln  Lys Lys Ala 
    1460                 1465                 1470             


Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg Lys Val  Thr Val Lys 
    1475                 1480                 1485             


Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser 
    1490                 1495                 1500             


Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly 
    1505                 1510                 1515             


Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
    1520                 1525                 1530             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1535                 1540                 1545             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1550                 1555                 1560             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1565                 1570                 1575             


Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1580                 1585                 1590             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1595                 1600                 1605             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1610                 1615                 1620             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1625                 1630                 1635             


Val Ser  Gly Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1640                 1645                 1650             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1655                 1660                 1665             


Val Val  Asp Glu Leu Val Lys  Val Met Gly Arg His  Lys Pro Glu 
    1670                 1675                 1680             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1685                 1690                 1695             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1700                 1705                 1710             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1715                 1720                 1725             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1730                 1735                 1740             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1745                 1750                 1755             


Leu Ser  Asp Tyr Asp Val Asp  Ala Ile Val Pro Gln  Ser Phe Leu 
    1760                 1765                 1770             


Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1775                 1780                 1785             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1790                 1795                 1800             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1805                 1810                 1815             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1820                 1825                 1830             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val 
    1835                 1840                 1845             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1850                 1855                 1860             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1865                 1870                 1875             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1880                 1885                 1890             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1895                 1900                 1905             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1910                 1915                 1920             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1925                 1930                 1935             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1940                 1945                 1950             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1955                 1960                 1965             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1970                 1975                 1980             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1985                 1990                 1995             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    2000                 2005                 2010             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    2015                 2020                 2025             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp 
    2030                 2035                 2040             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    2045                 2050                 2055             


Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    2060                 2065                 2070             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    2075                 2080                 2085             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    2090                 2095                 2100             


Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    2105                 2110                 2115             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    2120                 2125                 2130             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys 
    2135                 2140                 2145             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    2150                 2155                 2160             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    2165                 2170                 2175             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    2180                 2185                 2190             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    2195                 2200                 2205             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    2210                 2215                 2220             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    2225                 2230                 2235             


Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe 
    2240                 2245                 2250             


Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val 
    2255                 2260                 2265             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    2270                 2275                 2280             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Ala  Tyr Pro Tyr 
    2285                 2290                 2295             


Asp Val  Pro Asp Tyr Ala Pro  Arg Lys Asn Ser Ser  Leu Glu Gly 
    2300                 2305                 2310             


Pro Phe  Lys Pro Ala Asp Gln  Pro Arg Leu Cys Leu  Leu Val Ala 
    2315                 2320                 2325             


Ser His  Leu Leu Phe Ala Pro  Pro Pro Cys Leu Pro  
    2330                 2335                 2340 


<210> 36
<211> 1857
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Asn Ala Pro Glu Arg Gln Pro Gln Pro Asp Gly Gly Asp Ala Pro 
1               5                   10                  15      


Gly His Glu Pro Gly Gly Ser Pro Gln Asp Glu Leu Asp Phe Ser Ile 
            20                  25                  30          


Leu Phe Asp Tyr Glu Tyr Leu Asn Pro Asn Glu Glu Glu Pro Asn Ala 
        35                  40                  45              


His Lys Val Ala Ser Pro Pro Ser Gly Pro Ala Tyr Pro Asp Asp Val 
    50                  55                  60                  


Leu Asp Tyr Gly Leu Lys Pro Tyr Ser Pro Leu Ala Ser Leu Ser Gly 
65                  70                  75                  80  


Glu Pro Pro Gly Arg Phe Gly Glu Pro Asp Arg Val Gly Pro Gln Lys 
                85                  90                  95      


Phe Leu Ser Ala Ala Lys Pro Ala Gly Ala Ser Gly Leu Ser Pro Arg 
            100                 105                 110         


Ile Glu Ile Thr Pro Ser His Glu Leu Ile Gln Ala Val Gly Pro Leu 
        115                 120                 125             


Arg Met Arg Asp Ala Gly Leu Leu Val Glu Gln Pro Pro Leu Ala Gly 
    130                 135                 140                 


Val Ala Ala Ser Pro Arg Phe Thr Leu Pro Val Pro Gly Phe Glu Gly 
145                 150                 155                 160 


Tyr Arg Glu Pro Leu Cys Leu Ser Pro Ala Ser Ser Gly Ser Ser Ala 
                165                 170                 175     


Ser Phe Ile Ser Asp Thr Phe Ser Pro Tyr Thr Ser Pro Cys Val Ser 
            180                 185                 190         


Pro Asn Asn Gly Gly Pro Asp Asp Leu Cys Pro Gln Phe Gln Asn Ile 
        195                 200                 205             


Pro Ala His Tyr Ser Pro Arg Thr Ser Pro Ile Met Ser Pro Arg Thr 
    210                 215                 220                 


Ser Leu Ala Glu Asp Ser Cys Leu Gly Arg His Ser Pro Val Pro Arg 
225                 230                 235                 240 


Pro Ala Ser Arg Ser Ser Ser Pro Gly Ala Lys Arg Arg His Ser Cys 
                245                 250                 255     


Ala Glu Ala Leu Val Ala Leu Pro Pro Gly Ala Ser Pro Gln Arg Ser 
            260                 265                 270         


Arg Ser Pro Ser Pro Gln Pro Ser Ser His Val Ala Pro Gln Asp His 
        275                 280                 285             


Gly Ser Pro Ala Gly Tyr Pro Pro Val Ala Gly Ser Ala Val Ile Met 
    290                 295                 300                 


Asp Ala Leu Asn Ser Leu Ala Thr Asp Ser Pro Cys Gly Ile Pro Pro 
305                 310                 315                 320 


Lys Met Trp Lys Thr Ser Pro Asp Pro Ser Pro Val Ser Ala Ala Pro 
                325                 330                 335     


Ser Lys Ala Gly Leu Pro Arg His Ile Tyr Pro Ala Val Glu Phe Leu 
            340                 345                 350         


Gly Pro Cys Glu Gln Gly Glu Arg Arg Asn Ser Ala Pro Glu Ser Ile 
        355                 360                 365             


Leu Leu Val Pro Pro Thr Trp Pro Lys Pro Leu Val Pro Ala Ile Pro 
    370                 375                 380                 


Ile Cys Ser Ile Pro Val Thr Thr Ser Asp Lys Lys Tyr Ser Ile Gly 
385                 390                 395                 400 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
                405                 410                 415     


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
            420                 425                 430         


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
        435                 440                 445             


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
    450                 455                 460                 


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
465                 470                 475                 480 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
                485                 490                 495     


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
            500                 505                 510         


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
        515                 520                 525             


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
    530                 535                 540                 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
545                 550                 555                 560 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
                565                 570                 575     


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
            580                 585                 590         


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
        595                 600                 605             


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
    610                 615                 620                 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
625                 630                 635                 640 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
                645                 650                 655     


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
            660                 665                 670         


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
        675                 680                 685             


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
    690                 695                 700                 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
705                 710                 715                 720 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
                725                 730                 735     


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
            740                 745                 750         


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
        755                 760                 765             


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
    770                 775                 780                 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
785                 790                 795                 800 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
                805                 810                 815     


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
            820                 825                 830         


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
        835                 840                 845             


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
    850                 855                 860                 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
865                 870                 875                 880 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
                885                 890                 895     


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
            900                 905                 910         


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
        915                 920                 925             


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
    930                 935                 940                 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
945                 950                 955                 960 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
                965                 970                 975     


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
            980                 985                 990         


Ile Lys Asp Lys Asp Phe Leu Asp  Asn Glu Glu Asn Glu  Asp Ile Leu 
        995                 1000                 1005             


Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe Glu Asp  Arg Glu Met 
    1010                 1015                 1020             


Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His Leu Phe  Asp Asp Lys 
    1025                 1030                 1035             


Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr Thr Gly  Trp Gly Arg 
    1040                 1045                 1050             


Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg Asp Lys  Gln Ser Gly 
    1055                 1060                 1065             


Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp Gly Phe  Ala Asn Arg 
    1070                 1075                 1080             


Asn Phe  Met Gln Leu Ile His  Asp Asp Ser Leu Thr  Phe Lys Glu 
    1085                 1090                 1095             


Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln Gly Asp  Ser Leu His 
    1100                 1105                 1110             


Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro Ala Ile  Lys Lys Gly 
    1115                 1120                 1125             


Ile Leu  Gln Thr Val Lys Val  Val Asp Glu Leu Val  Lys Val Met 
    1130                 1135                 1140             


Gly Arg  His Lys Pro Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu 
    1145                 1150                 1155             


Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met 
    1160                 1165                 1170             


Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu 
    1175                 1180                 1185             


Lys Glu  His Pro Val Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu 
    1190                 1195                 1200             


Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
    1205                 1210                 1215             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp Ala Ile 
    1220                 1225                 1230             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1235                 1240                 1245             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1250                 1255                 1260             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1265                 1270                 1275             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1280                 1285                 1290             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1295                 1300                 1305             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1310                 1315                 1320             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1325                 1330                 1335             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1340                 1345                 1350             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1355                 1360                 1365             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1370                 1375                 1380             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1385                 1390                 1395             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1400                 1405                 1410             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1415                 1420                 1425             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1430                 1435                 1440             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1445                 1450                 1455             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1460                 1465                 1470             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1475                 1480                 1485             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1490                 1495                 1500             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1505                 1510                 1515             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1520                 1525                 1530             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1535                 1540                 1545             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1550                 1555                 1560             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1565                 1570                 1575             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1580                 1585                 1590             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1595                 1600                 1605             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1610                 1615                 1620             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1625                 1630                 1635             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1640                 1645                 1650             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1655                 1660                 1665             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1670                 1675                 1680             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1685                 1690                 1695             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1700                 1705                 1710             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1715                 1720                 1725             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1730                 1735                 1740             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1745                 1750                 1755             


Gly Asp  Ala Tyr Pro Tyr Asp  Val Pro Asp Tyr Ala  Ser Leu Gly 
    1760                 1765                 1770             


Ser Gly  Ser Gly Gly Ser Gly  Gly Gly Ser Met Asp  Ala Lys Ser 
    1775                 1780                 1785             


Leu Thr  Ala Trp Ser Arg Thr  Leu Val Thr Phe Lys  Asp Val Phe 
    1790                 1795                 1800             


Val Asp  Phe Thr Arg Glu Glu  Trp Lys Leu Leu Asp  Thr Ala Gln 
    1805                 1810                 1815             


Gln Ile  Val Tyr Arg Asn Val  Met Leu Glu Asn Tyr  Lys Asn Leu 
    1820                 1825                 1830             


Val Ser  Leu Gly Tyr Gln Leu  Thr Lys Pro Asp Val  Ile Leu Arg 
    1835                 1840                 1845             


Leu Glu  Lys Gly Glu Glu Pro  Leu Glu 
    1850                 1855         


<210> 37
<211> 1475
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
1               5                   10                  15      


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
            20                  25                  30          


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
        35                  40                  45              


Asp Met Leu Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Ser Asp Lys 
    50                  55                  60                  


Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala 
65                  70                  75                  80  


Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu 
                85                  90                  95      


Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu 
            100                 105                 110         


Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr 
        115                 120                 125             


Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln 
    130                 135                 140                 


Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His 
145                 150                 155                 160 


Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg 
                165                 170                 175     


His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys 
            180                 185                 190         


Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp 
        195                 200                 205             


Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys 
    210                 215                 220                 


Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser 
225                 230                 235                 240 


Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu 
                245                 250                 255     


Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile 
            260                 265                 270         


Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala 
        275                 280                 285             


Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala 
    290                 295                 300                 


Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala 
305                 310                 315                 320 


Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu 
                325                 330                 335     


Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu 
            340                 345                 350         


Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg 
        355                 360                 365             


Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys 
    370                 375                 380                 


Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val 
385                 390                 395                 400 


Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser 
                405                 410                 415     


Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu 
            420                 425                 430         


Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu 
        435                 440                 445             


Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg 
    450                 455                 460                 


Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu 
465                 470                 475                 480 


His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp 
                485                 490                 495     


Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr 
            500                 505                 510         


Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg 
        515                 520                 525             


Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp 
    530                 535                 540                 


Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp 
545                 550                 555                 560 


Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr 
                565                 570                 575     


Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr 
            580                 585                 590         


Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala 
        595                 600                 605             


Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln 
    610                 615                 620                 


Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu 
625                 630                 635                 640 


Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His 
                645                 650                 655     


Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu 
            660                 665                 670         


Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu 
        675                 680                 685             


Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe 
    690                 695                 700                 


Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp 
705                 710                 715                 720 


Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser 
                725                 730                 735     


Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg 
            740                 745                 750         


Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp 
        755                 760                 765             


Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His 
    770                 775                 780                 


Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
785                 790                 795                 800 


Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys 
                805                 810                 815     


Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln 
            820                 825                 830         


Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly 
        835                 840                 845             


Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn 
    850                 855                 860                 


Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly 
865                 870                 875                 880 


Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp 
                885                 890                 895     


Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser 
            900                 905                 910         


Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser 
        915                 920                 925             


Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp 
    930                 935                 940                 


Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn 
945                 950                 955                 960 


Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly 
                965                 970                 975     


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
            980                 985                 990         


Ala Gln Ile Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
        995                 1000                 1005             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1010                 1015                 1020             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1025                 1030                 1035             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1040                 1045                 1050             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1055                 1060                 1065             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1070                 1075                 1080             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1085                 1090                 1095             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1100                 1105                 1110             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1115                 1120                 1125             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1130                 1135                 1140             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1145                 1150                 1155             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1160                 1165                 1170             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1175                 1180                 1185             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1190                 1195                 1200             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1205                 1210                 1215             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1220                 1225                 1230             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1235                 1240                 1245             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1250                 1255                 1260             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1265                 1270                 1275             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1280                 1285                 1290             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1295                 1300                 1305             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1310                 1315                 1320             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1325                 1330                 1335             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1340                 1345                 1350             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1355                 1360                 1365             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1370                 1375                 1380             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1385                 1390                 1395             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1400                 1405                 1410             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1415                 1420                 1425             


Asp Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala Pro  Arg Lys Asn 
    1430                 1435                 1440             


Ser Ser  Leu Glu Gly Pro Phe  Lys Pro Ala Asp Gln  Pro Arg Leu 
    1445                 1450                 1455             


Cys Leu  Leu Val Ala Ser His  Leu Leu Phe Ala Pro  Pro Pro Cys 
    1460                 1465                 1470             


Leu Pro  
    1475 


<210> 38
<211> 1848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val 
1               5                   10                  15      


Phe Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly 
            20                  25                  30          


Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu 
        35                  40                  45              


Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro 
    50                  55                  60                  


Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro 
65                  70                  75                  80  


Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly 
                85                  90                  95      


Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu 
            100                 105                 110         


Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro 
        115                 120                 125             


Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg 
    130                 135                 140                 


Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly 
145                 150                 155                 160 


Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu 
                165                 170                 175     


Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr 
            180                 185                 190         


Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg 
        195                 200                 205             


Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro 
    210                 215                 220                 


Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly 
225                 230                 235                 240 


Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr 
                245                 250                 255     


Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser 
            260                 265                 270         


Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly 
        275                 280                 285             


Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro 
    290                 295                 300                 


Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala 
305                 310                 315                 320 


Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu 
                325                 330                 335     


Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly 
            340                 345                 350         


Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser 
        355                 360                 365             


Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu 
    370                 375                 380                 


Ala Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr 
385                 390                 395                 400 


Thr Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser 
                405                 410                 415     


Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys 
            420                 425                 430         


Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu 
        435                 440                 445             


Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    450                 455                 460                 


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile 
465                 470                 475                 480 


Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp 
                485                 490                 495     


Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys 
            500                 505                 510         


Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala 
        515                 520                 525             


Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val 
    530                 535                 540                 


Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
545                 550                 555                 560 


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn 
                565                 570                 575     


Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr 
            580                 585                 590         


Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp 
        595                 600                 605             


Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu 
    610                 615                 620                 


Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly 
625                 630                 635                 640 


Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn 
                645                 650                 655     


Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr 
            660                 665                 670         


Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala 
        675                 680                 685             


Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser 
    690                 695                 700                 


Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala 
705                 710                 715                 720 


Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu 
                725                 730                 735     


Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe 
            740                 745                 750         


Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala 
        755                 760                 765             


Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met 
    770                 775                 780                 


Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu 
785                 790                 795                 800 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                805                 810                 815     


Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro 
            820                 825                 830         


Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        835                 840                 845             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala 
    850                 855                 860                 


Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu 
865                 870                 875                 880 


Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met 
                885                 890                 895     


Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His 
            900                 905                 910         


Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        915                 920                 925             


Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu 
    930                 935                 940                 


Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val 
945                 950                 955                 960 


Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe 
                965                 970                 975     


Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu 
            980                 985                 990         


Gly Thr Tyr His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
        995                 1000                 1005             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1010                 1015                 1020             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1025                 1030                 1035             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1040                 1045                 1050             


Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1055                 1060                 1065             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1070                 1075                 1080             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1085                 1090                 1095             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1100                 1105                 1110             


Val Ser  Gly Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1115                 1120                 1125             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1130                 1135                 1140             


Val Val  Asp Glu Leu Val Lys  Val Met Gly Arg His  Lys Pro Glu 
    1145                 1150                 1155             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1160                 1165                 1170             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1175                 1180                 1185             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1190                 1195                 1200             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1205                 1210                 1215             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1220                 1225                 1230             


Leu Ser  Asp Tyr Asp Val Asp  Ala Ile Val Pro Gln  Ser Phe Leu 
    1235                 1240                 1245             


Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1250                 1255                 1260             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1265                 1270                 1275             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1280                 1285                 1290             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1295                 1300                 1305             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val 
    1310                 1315                 1320             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1325                 1330                 1335             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1340                 1345                 1350             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1355                 1360                 1365             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1370                 1375                 1380             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1385                 1390                 1395             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1400                 1405                 1410             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1415                 1420                 1425             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1430                 1435                 1440             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1445                 1450                 1455             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1460                 1465                 1470             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1475                 1480                 1485             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1490                 1495                 1500             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp 
    1505                 1510                 1515             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    1520                 1525                 1530             


Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    1535                 1540                 1545             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    1550                 1555                 1560             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    1565                 1570                 1575             


Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    1580                 1585                 1590             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    1595                 1600                 1605             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys 
    1610                 1615                 1620             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    1625                 1630                 1635             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    1640                 1645                 1650             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    1655                 1660                 1665             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    1670                 1675                 1680             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    1685                 1690                 1695             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    1700                 1705                 1710             


Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe 
    1715                 1720                 1725             


Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val 
    1730                 1735                 1740             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    1745                 1750                 1755             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Ala  Tyr Pro Tyr 
    1760                 1765                 1770             


Asp Val  Pro Asp Tyr Ala Ser  Leu Gly Ser Gly Asp  Gly Ile Gly 
    1775                 1780                 1785             


Ser Gly  Ser Asn Gly Ser Ser  Leu Asp Ala Leu Asp  Asp Phe Asp 
    1790                 1795                 1800             


Leu Asp  Met Leu Gly Ser Asp  Ala Leu Asp Asp Phe  Asp Leu Asp 
    1805                 1810                 1815             


Met Leu  Gly Ser Asp Ala Leu  Asp Asp Phe Asp Leu  Asp Met Leu 
    1820                 1825                 1830             


Gly Ser  Asp Ala Leu Asp Asp  Phe Asp Leu Asp Met  Leu Gly Ser 
    1835                 1840                 1845             


<210> 39
<211> 1711
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Pro Ser Asp Phe Ile Ser Leu Leu Ser Ala Asp Leu Asp Leu Glu 
1               5                   10                  15      


Ser Pro Lys Ser Leu Tyr Ser Arg Glu Ser Val Tyr Asp Leu Leu Pro 
            20                  25                  30          


Lys Glu Leu Gln Leu Pro Pro Ser Arg Glu Thr Ser Val Ala Ser Met 
        35                  40                  45              


Ser Gln Thr Ser Gly Gly Glu Ala Gly Ser Pro Pro Pro Ala Val Val 
    50                  55                  60                  


Ala Ala Asp Ala Ser Ser Ala Pro Ser Ser Ser Ser Met Gly Gly Ala 
65                  70                  75                  80  


Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile Tyr Ser Thr Ser 
                85                  90                  95      


Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys Ser Ser Ala Val 
            100                 105                 110         


Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu Thr Ser Asn Thr 
        115                 120                 125             


Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr Val Leu Tyr Ile 
    130                 135                 140                 


Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg Met Ser Cys Gln 
145                 150                 155                 160 


Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys Ser Met Trp Met 
                165                 170                 175     


Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr Ser Ser Tyr Asn 
            180                 185                 190         


Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg Asn Pro Lys Gln 
        195                 200                 205             


Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser Asn Met Asp Ile 
    210                 215                 220                 


Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val Leu Ser Gln Leu 
225                 230                 235                 240 


Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn Gly Thr Leu Glu 
                245                 250                 255     


Asn Gln Lys Gly Thr Gly Val Thr Ser Asp Lys Lys Tyr Ser Ile Gly 
            260                 265                 270         


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
        275                 280                 285             


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
    290                 295                 300                 


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
305                 310                 315                 320 


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
                325                 330                 335     


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
            340                 345                 350         


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
        355                 360                 365             


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
    370                 375                 380                 


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
385                 390                 395                 400 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
                405                 410                 415     


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
            420                 425                 430         


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
        435                 440                 445             


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
    450                 455                 460                 


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
465                 470                 475                 480 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
                485                 490                 495     


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
            500                 505                 510         


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
        515                 520                 525             


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
    530                 535                 540                 


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
545                 550                 555                 560 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
                565                 570                 575     


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
            580                 585                 590         


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
        595                 600                 605             


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
    610                 615                 620                 


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
625                 630                 635                 640 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
                645                 650                 655     


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
            660                 665                 670         


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
        675                 680                 685             


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
    690                 695                 700                 


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
705                 710                 715                 720 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
                725                 730                 735     


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
            740                 745                 750         


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
        755                 760                 765             


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
    770                 775                 780                 


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
785                 790                 795                 800 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
                805                 810                 815     


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
            820                 825                 830         


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
        835                 840                 845             


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
    850                 855                 860                 


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
865                 870                 875                 880 


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
                885                 890                 895     


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
            900                 905                 910         


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
        915                 920                 925             


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
    930                 935                 940                 


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
945                 950                 955                 960 


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
                965                 970                 975     


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
            980                 985                 990         


Gly Ser Pro Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
        995                 1000                 1005             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1010                 1015                 1020             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1025                 1030                 1035             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1040                 1045                 1050             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1055                 1060                 1065             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1070                 1075                 1080             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1085                 1090                 1095             


Asp Tyr  Asp Val Asp Ala Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1100                 1105                 1110             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1115                 1120                 1125             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1130                 1135                 1140             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1145                 1150                 1155             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1160                 1165                 1170             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1175                 1180                 1185             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1190                 1195                 1200             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1205                 1210                 1215             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1220                 1225                 1230             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1235                 1240                 1245             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1250                 1255                 1260             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1265                 1270                 1275             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1280                 1285                 1290             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1295                 1300                 1305             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1310                 1315                 1320             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1325                 1330                 1335             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1340                 1345                 1350             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1355                 1360                 1365             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1370                 1375                 1380             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1385                 1390                 1395             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1400                 1405                 1410             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1415                 1420                 1425             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1430                 1435                 1440             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1445                 1450                 1455             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1460                 1465                 1470             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1475                 1480                 1485             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1490                 1495                 1500             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1505                 1510                 1515             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1520                 1525                 1530             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1535                 1540                 1545             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1550                 1555                 1560             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1565                 1570                 1575             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1580                 1585                 1590             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1595                 1600                 1605             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1610                 1615                 1620             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ala Tyr Pro  Tyr Asp Val 
    1625                 1630                 1635             


Pro Asp  Tyr Ala Ser Leu Gly  Ser Gly Asp Gly Ile  Gly Ser Gly 
    1640                 1645                 1650             


Ser Asn  Gly Ser Ser Leu Asp  Ala Leu Asp Asp Phe  Asp Leu Asp 
    1655                 1660                 1665             


Met Leu  Gly Ser Asp Ala Leu  Asp Asp Phe Asp Leu  Asp Met Leu 
    1670                 1675                 1680             


Gly Ser  Asp Ala Leu Asp Asp  Phe Asp Leu Asp Met  Leu Gly Ser 
    1685                 1690                 1695             


Asp Ala  Leu Asp Asp Phe Asp  Leu Asp Met Leu Gly  Ser 
    1700                 1705                 1710     


<210> 40
<211> 1754
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Asp Glu Leu Phe Pro Leu Ile Phe Pro Ala Glu Pro Ala Gln Ala 
1               5                   10                  15      


Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly Met 
            20                  25                  30          


Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro Gly 
        35                  40                  45              


Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile Asn 
    50                  55                  60                  


Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys Asp 
65                  70                  75                  80  


Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys Arg 
                85                  90                  95      


Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp Arg Cys Ile His Ser 
            100                 105                 110         


Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu Gln 
        115                 120                 125             


Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe Gln Val Pro 
    130                 135                 140                 


Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu Cys 
145                 150                 155                 160 


Phe Gln Val Thr Val Arg Asp Pro Ser Gly Arg Pro Leu Arg Leu Pro 
                165                 170                 175     


Pro Val Leu Ser His Pro Ile Phe Asp Asn Arg Ala Pro Asn Thr Ala 
            180                 185                 190         


Glu Leu Lys Ile Cys Arg Val Asn Arg Asn Ser Gly Ser Cys Leu Gly 
        195                 200                 205             


Gly Asp Glu Ile Phe Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile 
    210                 215                 220                 


Glu Val Tyr Phe Thr Gly Pro Gly Trp Glu Ala Arg Gly Ser Phe Ser 
225                 230                 235                 240 


Gln Ala Asp Val His Arg Gln Val Ala Ile Val Phe Arg Thr Pro Pro 
                245                 250                 255     


Tyr Ala Asp Pro Ser Leu Gln Ala Pro Val Arg Val Ser Met Gln Leu 
            260                 265                 270         


Arg Arg Pro Ser Asp Arg Glu Leu Ser Glu Pro Met Glu Phe Gln Tyr 
        275                 280                 285             


Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg 
    290                 295                 300                 


Thr Tyr Thr Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
305                 310                 315                 320 


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
                325                 330                 335     


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
            340                 345                 350         


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
        355                 360                 365             


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
    370                 375                 380                 


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
385                 390                 395                 400 


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
                405                 410                 415     


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
            420                 425                 430         


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
        435                 440                 445             


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
    450                 455                 460                 


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
465                 470                 475                 480 


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
                485                 490                 495     


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
            500                 505                 510         


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
        515                 520                 525             


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
    530                 535                 540                 


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
545                 550                 555                 560 


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
                565                 570                 575     


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
            580                 585                 590         


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
        595                 600                 605             


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
    610                 615                 620                 


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
625                 630                 635                 640 


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
                645                 650                 655     


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
            660                 665                 670         


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
        675                 680                 685             


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
    690                 695                 700                 


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
705                 710                 715                 720 


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
                725                 730                 735     


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
            740                 745                 750         


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
        755                 760                 765             


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
    770                 775                 780                 


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
785                 790                 795                 800 


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
                805                 810                 815     


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
            820                 825                 830         


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
        835                 840                 845             


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
    850                 855                 860                 


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
865                 870                 875                 880 


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
                885                 890                 895     


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
            900                 905                 910         


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
        915                 920                 925             


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
    930                 935                 940                 


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
945                 950                 955                 960 


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
                965                 970                 975     


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
            980                 985                 990         


Asp Gly Phe Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
        995                 1000                 1005             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1010                 1015                 1020             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1025                 1030                 1035             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1040                 1045                 1050             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1055                 1060                 1065             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1070                 1075                 1080             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1085                 1090                 1095             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1100                 1105                 1110             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1115                 1120                 1125             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1130                 1135                 1140             


Asp Val  Asp Ala Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1145                 1150                 1155             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1160                 1165                 1170             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1175                 1180                 1185             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1190                 1195                 1200             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1205                 1210                 1215             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1220                 1225                 1230             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1235                 1240                 1245             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1250                 1255                 1260             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1265                 1270                 1275             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1280                 1285                 1290             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1295                 1300                 1305             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1310                 1315                 1320             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1325                 1330                 1335             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1340                 1345                 1350             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1355                 1360                 1365             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1370                 1375                 1380             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1385                 1390                 1395             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1400                 1405                 1410             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1415                 1420                 1425             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1430                 1435                 1440             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1445                 1450                 1455             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1460                 1465                 1470             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1475                 1480                 1485             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1490                 1495                 1500             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1505                 1510                 1515             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1520                 1525                 1530             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1535                 1540                 1545             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1550                 1555                 1560             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1565                 1570                 1575             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1580                 1585                 1590             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1595                 1600                 1605             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1610                 1615                 1620             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1625                 1630                 1635             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1640                 1645                 1650             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1655                 1660                 1665             


Leu Ser  Gln Leu Gly Gly Asp  Ala Tyr Pro Tyr Asp  Val Pro Asp 
    1670                 1675                 1680             


Tyr Ala  Ser Leu Gly Ser Gly  Asp Gly Ile Gly Ser  Gly Ser Asn 
    1685                 1690                 1695             


Gly Ser  Ser Leu Asp Ala Leu  Asp Asp Phe Asp Leu  Asp Met Leu 
    1700                 1705                 1710             


Gly Ser  Asp Ala Leu Asp Asp  Phe Asp Leu Asp Met  Leu Gly Ser 
    1715                 1720                 1725             


Asp Ala  Leu Asp Asp Phe Asp  Leu Asp Met Leu Gly  Ser Asp Ala 
    1730                 1735                 1740             


Leu Asp  Asp Phe Asp Leu Asp  Met Leu Gly Ser 
    1745                 1750                 


