                               SEQUENCE LISTING

<110> CARMOT THERAPEUTICS, INC.
 
<120> MODULATORS OF G-PROTEIN COUPLED RECEPTORS

<130> 41517-0002WO1

<140>
<141>

<150> 62/647,604
<151> 2018-03-23

<160> 58    

<170> PatentIn version 3.5

<210> 1
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(33)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (4)..(33)
<223> This region may encompass 20-30 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 1
Gly Thr Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40              


<210> 2
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Thr or Ile

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Tyr, Val or Leu

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ile or Ser

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Tyr, Gln or Ala

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Leu, Met or 2-amino-2-methylpentanoic acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp or Glu

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Lys, Gly or Glu

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala or Val

<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid or Lys

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Glu or Leu

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Val or Ile

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Asn, Ala or Glu

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Leu or Val

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala or Lys

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 2
Gly Thr Phe Xaa Ser Asp Xaa Ser Xaa Xaa Xaa Xaa Xaa Gln Ala Xaa 
1               5                   10                  15      


Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser 
        35      


<210> 3
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Thr or Ile

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Tyr, Val or Leu

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ile or Ser

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Tyr, Gln or Ala

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Leu, Met or 2-amino-2-methylpentanoic acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp or Glu

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Lys, Gly or Glu

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala or Val

<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Glu or Leu

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Val or Ile

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Asn, Ala or Glu

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Leu or Val

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala or Lys

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 3
Gly Thr Phe Xaa Ser Asp Xaa Ser Xaa Xaa Xaa Xaa Xaa Gln Ala Xaa 
1               5                   10                  15      


Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser 
        35      


<210> 4
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<400> 4
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser 
        35      


<210> 5
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<400> 5
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 6
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 6
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 7
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 7
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 8
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 8
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 9
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 9
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 10
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 10
Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala 
1               5                   10                  15      


Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 11
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 11
Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile Arg Gln 
1               5                   10                  15      


Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Arg Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 12
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<400> 12
Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 13
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<400> 13
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 14
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<400> 14
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Val 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 15
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<400> 15
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Leu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 16
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<400> 16
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Ile Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 17
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<400> 17
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Glu Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 18
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<400> 18
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Val 
1               5                   10                  15      


Xaa Glu Phe Ile Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 19
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 19
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Gln Met Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 20
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 20
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Ala Met Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 21
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (11)..(11)
<223> 2-amino-2-methylpentanoic acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 21
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Xaa Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 22
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<400> 22
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Arg Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser 
        35      


<210> 23
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 23
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Val Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 24
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 24
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Lys Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 25
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 25
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Arg Gly Lys Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210> 26
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 26
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 27
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 27
Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 28
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 28
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 29
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> 2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 29
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 30
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 30
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Val 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 31
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 31
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Lys Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 32
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 32
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Arg Gly Lys Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210> 33
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 33
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 34
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 34
Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 35
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Thr or Ile

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Tyr, Val, Leu or Lys

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ile or Ser

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Tyr, 2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid, Gln,
      Ala or 2-aminoisobutyric acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Leu, Met or 2-amino-2-methylpentanoic acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp or Glu

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Lys, Gly, Arg or Glu

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Gln or Ile

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, His or Arg

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Gln or Val

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, 2-aminoisobutyric acid, Lys or Gln

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Asp, Glu, 2-aminoisobutyric acid or Leu

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Phe or Ala

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Val or Ile

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Asn, Ala, Gln, Lys or Glu

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ile, Leu or Val

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Lys or Ile

<220>
<221> MOD_RES
<222> (26)..(29)
<223> This region may encompass 'Gly-Arg-Gly-Lys' or
      'Gln-Arg' or 'Gln' or 'Gly'

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Ser or absent

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 35
Gly Thr Phe Xaa Ser Asp Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Trp Leu Xaa Xaa Xaa Xaa Xaa Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210> 36
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<400> 36
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 37
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 37
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 38
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> D-Glu

<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 38
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 39
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 39
Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala 
1               5                   10                  15      


Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 40
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 40
Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile Arg 
1               5                   10                  15      


Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Arg Gly Pro Ser Ser 
            20                  25                  30          


Gly Ala Pro Pro Pro Ser Lys 
        35                  


<210> 41
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<400> 41
Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 42
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<400> 42
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 43
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<400> 43
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Val Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 44
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<400> 44
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Leu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 45
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<400> 45
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Ile Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 46
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<400> 46
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Glu Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 47
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<400> 47
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Val Xaa Glu Phe Ile Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 48
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 48
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Gln Met Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 49
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 49
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Ala Met Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 50
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (12)..(12)
<223> 2-amino-2-methylpentanoic acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 50
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Xaa Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 51
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<400> 51
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Arg Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser 
        35          


<210> 52
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 52
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Val Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 53
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 53
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Lys Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 54
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 54
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Arg Gly Lys Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210> 55
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 55
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 56
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 56
Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


<210> 57
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 57
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys Gln Ala Ala 
1               5                   10                  15      


Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala 
            20                  25                  30          


Pro Pro Pro Ser Lys 
        35          


<210> 58
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (11)..(11)
<223> 2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> 2-aminoisobutyric acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 58
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys Gln Ala 
1               5                   10                  15      


Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly 
            20                  25                  30          


Ala Pro Pro Pro Ser Lys 
        35              


