                         SEQUENCE LISTING

<110>  Danmarks Tekniske Universitet
 
<120>  A high-throughput platform to select for regulators of 
       CRISPR-associated activity

<130>  P2394PC00

<150>  EP18164235.6
<151>  2018-03-27

<150>  EP18209315.3
<151>  2018-11-29

<160>  177   

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Archaeoglobus fulgidus


<220>
<221>  PEPTIDE
<222>  (1)..(116)
<223>  type I-A CRISPR-associated protein Csa5: WP_010879363.1

<400>  1

Met Ser Ser Thr Met Ser Phe Asp Asn Leu Ala Lys Val Leu Ala Val 
1               5                   10                  15      


Leu Val Ala Glu Gln Gly Ser Tyr Thr Tyr Val Asp Lys Leu Gly Tyr 
            20                  25                  30          


Val Pro Ser Lys Asp Leu Ala Val Phe Tyr Leu Lys Glu Ala Leu Arg 
        35                  40                  45              


Asp Leu His Ser Ile Gln Gln Lys Glu Lys Phe Glu Asn Glu Lys Ala 
    50                  55                  60                  


Arg Glu Leu Val Gly Lys Ile Asp Tyr Glu Arg Val Glu Lys Glu Leu 
65                  70                  75                  80  


Glu Asp Ile Ala Lys Thr Asp Glu Arg Lys Glu Leu Arg Glu Lys Thr 
                85                  90                  95      


Ser Leu Ile Ala Ala Lys Ala Leu Ala Leu Ser Ala Lys Leu Gly Gly 
            100                 105                 110         


Gly Ser Gly Glu 
        115     


<210>  2
<211>  319
<212>  PRT
<213>  Archaeoglobus fulgidus


<220>
<221>  PEPTIDE
<222>  (1)..(319)
<223>  type I-A CRISPR-associated protein Cas7/Csa2: WP_010879364.1

<400>  2

Met Val Val Val Ser Asp Val Phe Val Ser Val Arg Gly Arg Val Met 
1               5                   10                  15      


Leu Asn Val Glu Ala Met Asn Met Thr Glu Ser Val Gly Asn Tyr Val 
            20                  25                  30          


Lys His Arg Arg Val Pro Val Val Leu Pro Asp Ala Lys Tyr Thr Thr 
        35                  40                  45              


Tyr Phe Val Pro Ala Ile Ser Gly Glu Ser Ile Ala His Gly Phe Gln 
    50                  55                  60                  


Glu Val Leu Ala Glu Val Gly Lys Lys Asn Gly Leu Lys Val Cys Lys 
65                  70                  75                  80  


Leu Cys Glu Lys Gly Ile Phe Leu Lys Ser Thr Asn Glu Asn Val Phe 
                85                  90                  95      


Lys Glu Ser Phe Ser Ser Asp Pro Pro Lys Asp Asp Phe Glu Phe Glu 
            100                 105                 110         


Lys Thr Val Ile Glu Asn Cys Ile Val Glu Asp Val Gly Gly Phe Leu 
        115                 120                 125             


Tyr Ala Pro Arg Ala Gly Gly Asn Val Lys Arg Thr Ser Asn Phe Tyr 
    130                 135                 140                 


Thr Gly Tyr Met Ile Pro Val Arg Glu Ser Ile Glu Gly Ala Val Ile 
145                 150                 155                 160 


Glu Pro Gln Leu His Ser Arg Tyr Ala Leu Gly Thr Pro Phe Val Glu 
                165                 170                 175     


Gly Gly Gln Gly Gln Met Ile Tyr Tyr Val Glu Leu Ser Ser Ala Val 
            180                 185                 190         


Tyr Thr Phe Ser Phe Asp Leu Asp Thr Arg Tyr Ile Gly Arg Thr Thr 
        195                 200                 205             


Phe Ser Tyr Glu Lys Ala Gly Thr Glu Val Gly Lys Arg Ser Glu Arg 
    210                 215                 220                 


Ile Asn Ala Ala Leu Glu Ala Leu Lys Lys Phe Leu Ile Glu Phe Ala 
225                 230                 235                 240 


Phe Gly Ala Lys Lys Thr Arg Phe Leu Pro Val Met Glu Trp Asp Ser 
                245                 250                 255     


Leu Val Val Ala Val Ser Asp Asp Val Trp Thr Val Pro Ser Pro Tyr 
            260                 265                 270         


Thr Ala Gly Tyr Ile Asp Asn Ala Arg Lys Lys Lys Glu Lys Val Asn 
        275                 280                 285             


Phe Asn Thr Lys Leu Phe Val Tyr Pro Glu Gly Gly Ser Phe Glu Glu 
    290                 295                 300                 


Val Val Val Glu Ala Ile Glu Glu Ala Lys Glu Arg Ala Gly Lys 
305                 310                 315                 


<210>  3
<211>  266
<212>  PRT
<213>  Archaeoglobus fulgidus


<220>
<221>  PEPTIDE
<222>  (1)..(266)
<223>  type I-A CRISPR-associated protein Cas5: WP_010879365.1

<400>  3

Met Ile Gly Tyr Leu Val Asp Val Glu Phe Val Trp Gly Phe Gln Ala 
1               5                   10                  15      


Arg Ile Ala Gly Leu Ser Lys Thr Ser Pro Ser Phe Tyr Tyr Pro Pro 
            20                  25                  30          


Pro Thr Thr Phe Leu Gly Ala Val Ala Glu Ala Ile Ala Lys Asp Lys 
        35                  40                  45              


Gly Ile Gly Glu Gln Arg Gly Lys Glu Ile Ile Ser Glu Leu Gly Glu 
    50                  55                  60                  


Asn Leu Leu Ala Ile Gly Trp Lys Ala Leu Asn Cys Thr Pro Leu Arg 
65                  70                  75                  80  


Tyr Ser Asp Ile Asn Arg Ile Leu Ala Val Lys Ile Thr Ser Gly Val 
                85                  90                  95      


Leu Tyr Pro Asn Pro Gln Asp Leu Ala Lys Ser Phe Asp Ser Pro Ala 
            100                 105                 110         


Arg Gly Lys Thr Ile Leu Ser Ser Leu Asn Asp Glu Ala Pro Lys Ile 
        115                 120                 125             


Arg Trp Phe Leu Val Phe Lys Glu Glu Ala Val Glu Glu Lys Ile Leu 
    130                 135                 140                 


Trp Lys Ile His Arg Ile Gly Ser Lys Glu Ser Arg Val Ala Val Val 
145                 150                 155                 160 


Asp Val Lys Lys Val Lys Val Thr Gln Lys Asp Gly Leu Ile Ser Thr 
                165                 170                 175     


Asp Tyr Ser Phe Pro Ala Glu Asp Gly Val Glu Leu Arg Gly Ile Leu 
            180                 185                 190         


Ser Gln Arg Trp Glu Phe Glu Val Tyr Leu Asn Pro Phe Glu Val Lys 
        195                 200                 205             


Tyr Ser Glu Lys Glu Asn Pro Leu Met Ser Tyr Ile Ser Gly Lys Lys 
    210                 215                 220                 


Ala Val Leu Tyr Arg Ile Pro Ile Met Thr Ser Ile Phe Ser Thr Pro 
225                 230                 235                 240 


Glu Cys Leu Val Glu Val Gly Gly Asp Phe Lys Ala Tyr Glu Ala Gly 
                245                 250                 255     


Gly Glu Val Val Ile Gly Arg Cys Ser Lys 
            260                 265     


<210>  4
<211>  390
<212>  PRT
<213>  Archaeoglobus fulgidus


<220>
<221>  PROPEP
<222>  (1)..(390)
<223>  hypothetical protein; WP_010879366.1

<400>  4

Met Leu Lys Val Lys Leu Ser Leu Pro Pro Asp Ser Thr Phe Leu Ser 
1               5                   10                  15      


Gln Leu Ile Tyr Glu Ser Leu Leu Tyr Leu Ser Gly Lys Lys Leu Ala 
            20                  25                  30          


Lys Phe Glu Asn Gly Glu Leu Leu Ile Glu Ser Ile Ser Lys Ala Leu 
        35                  40                  45              


Glu Thr Phe Asp Asp Glu Arg Val Gly Glu Ile Arg Ile Val Met Ser 
    50                  55                  60                  


Gly Asn Asp Asn Ile Asn Ala Lys Ile Phe Glu Thr Phe Gly Ile Gly 
65                  70                  75                  80  


Gly Val Lys Ser Arg Lys Thr Tyr Tyr Asp Leu Ile Ala Leu Leu Lys 
                85                  90                  95      


Glu His Arg Asp Lys Ile Ser Thr Lys Asp Glu Ser Glu Ile His Leu 
            100                 105                 110         


Asn Ile Lys Gly Lys Asp Val Phe Met Asp Ile Asn Ser Lys Ser Asp 
        115                 120                 125             


Gly Ile Ala Ala Pro Gln Leu Leu Lys Val Asp Arg Tyr Thr Gly Phe 
    130                 135                 140                 


Ser Ser Leu Asp Thr Pro Tyr Thr Ser Gln Gln Leu Thr Phe Tyr Leu 
145                 150                 155                 160 


Ser Lys Glu Val Ala Leu Leu Ala Leu Leu Gly Ile Tyr Ser Ser Phe 
                165                 170                 175     


Val Thr Asn Val Arg Gln Gln Gln Gln Ser Tyr Tyr Tyr Phe Leu Phe 
            180                 185                 190         


Phe Ser Pro Glu Glu Val Ala Gly Leu Leu Asn Ser Pro Ser Leu Ala 
        195                 200                 205             


Glu Lys Phe Phe Leu Val Lys Glu Ser Val Arg Glu Ser Leu Arg Glu 
    210                 215                 220                 


Leu Leu Arg Arg Thr Thr Phe Asn Glu Leu Leu Leu Ile Glu Thr Thr 
225                 230                 235                 240 


Leu Asn Leu Glu Leu Gln Arg Leu Met Glu Thr Glu Asn Leu Asp Lys 
                245                 250                 255     


Ile Ser Leu Thr Leu Phe Lys Ile Ala His Glu Gly Gln Thr Tyr Lys 
            260                 265                 270         


Ile Tyr Glu Gln Ile Pro Ile Thr Val Tyr Arg Asn Pro Ala Phe Tyr 
        275                 280                 285             


Glu Thr Ala Lys Lys Tyr Phe Arg Asp Pro Leu Lys Phe Ser Glu Lys 
    290                 295                 300                 


Leu Arg Lys Ala Ile Thr Gln Gly Val Ile Pro Ser Ala Leu Ala Ile 
305                 310                 315                 320 


Leu Ser Thr Lys Asn Lys Tyr Ser Glu Ala Asp Asn Ile Leu Lys Ala 
                325                 330                 335     


Ile Gln Met Leu Tyr Arg Phe Val Val Leu Gly Asp Leu Gln Gly Trp 
            340                 345                 350         


Phe Gly Phe Leu Arg Glu Leu Asn Asn Ala His Ser Lys Leu Lys Asn 
        355                 360                 365             


Ser Ser Asp Gly Arg Glu Lys Lys Arg Ala Gly Gln Tyr Leu Asn Ile 
    370                 375                 380                 


Val Lys Glu Val Ala Trp 
385                 390 


<210>  5
<211>  546
<212>  PRT
<213>  Archaeoglobus fulgidus


<220>
<221>  PEPTIDE
<222>  (1)..(546)
<223>  CRISPR-associated helicase Cas3': WP_010879367.1

<400>  5

Met Val Thr Leu Ser Glu Ile Tyr Gly Glu Ile Val Glu Lys Trp Phe 
1               5                   10                  15      


Gly Gly Arg Asp Glu Arg Pro Phe Ile Ala Asn Ala Ile Arg Glu Ile 
            20                  25                  30          


Glu Lys Asn Trp Asp Arg Asn Ile Phe Val Ile Glu Ala Pro Thr Gly 
        35                  40                  45              


Tyr Gly Lys Ser Thr Ile Ser Ala Thr Ile Ala Ala Tyr Ser Leu Gln 
    50                  55                  60                  


Glu Glu Leu Lys Ser Ile Ile Ala Phe Pro Leu Arg Thr Leu Leu Glu 
65                  70                  75                  80  


Asp Gln Tyr Asn Lys Phe Lys Gly Leu Phe Gly Asn Lys Leu Gly Lys 
                85                  90                  95      


Arg Tyr Met His Asn Pro Asp Ser Pro Tyr Leu Ile Lys Pro Val Thr 
            100                 105                 110         


Leu Thr Thr Ile Asp Thr Leu Ala Leu Thr Leu Phe Gly Ile Pro Pro 
        115                 120                 125             


Glu Asp Leu Asp Lys Ala Val Lys Tyr Trp Asp Gly Thr Ser Ser Gly 
    130                 135                 140                 


Ser Leu Gly His Tyr Leu Phe Ser Gln Ala Ser Val Ala Leu Ser Asn 
145                 150                 155                 160 


Ile Val Leu Asp Glu Val His Leu Leu Ala Asp Ser Thr Lys Ser Leu 
                165                 170                 175     


Asn Phe Leu Phe Ala Leu Met His Ala Ala Ile Asp Asn Asp Gln Lys 
            180                 185                 190         


Leu Val Leu Met Ser Ala Thr Ile Pro Glu Ala Leu Lys Lys Arg Ile 
        195                 200                 205             


Lys Glu Phe Asn Pro Asp Val Cys Met Val Glu Phe Asn Glu Ser Phe 
    210                 215                 220                 


Asp Arg Lys Phe Val Glu Glu Arg Arg Lys Lys Lys Tyr Arg Ile Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ala Ser Val Glu Lys Phe Gly Ser Leu Glu Arg Ile 
                245                 250                 255     


Leu Leu Glu Gly Ser Lys Lys Phe Ser Lys Ile Thr Val Val Phe Asn 
            260                 265                 270         


Thr Ile Gly Asp Ala Val Tyr Phe Tyr Asn Asn Ile Lys Glu Lys Ile 
        275                 280                 285             


Pro Glu Phe Lys Lys Leu Leu Leu His Ser Arg Phe Ser Glu Met Asp 
    290                 295                 300                 


Arg Glu Lys Lys Ala Glu Leu Leu Ala Glu Met Lys Lys Ser Glu Lys 
305                 310                 315                 320 


Phe Val Ile Val Thr Thr Gln Val Ile Glu Ala Gly Val Asp Ile Ser 
                325                 330                 335     


Ser Asn Leu Phe Ile Thr Glu Ile Ala Pro Ala Ser Ser Leu Ile Gln 
            340                 345                 350         


Arg Leu Gly Arg Phe Leu Arg Tyr Gly Glu Arg Glu Gly Glu Val Tyr 
        355                 360                 365             


Ile Trp Tyr Glu Val Asp Asp Arg Gly Glu Leu Ala Arg Trp Lys Asp 
    370                 375                 380                 


Asp Arg Tyr Lys Val Tyr Asp Tyr Ser Leu Thr Ala Leu Thr Leu Glu 
385                 390                 395                 400 


Lys Leu Ala Glu Met Lys Asn Phe Ser Val His Val Asp Tyr Asp Arg 
                405                 410                 415     


Leu Leu Asp Val Tyr Gly Glu Phe Glu Val Asp Glu Arg Gly Val Asn 
            420                 425                 430         


Asp Leu Arg Arg Ile Leu Met Asn Phe Glu Asn Ile Asn Ser Ala Val 
        435                 440                 445             


Glu Lys Phe Phe Glu Leu Glu Gly Ser Phe Val Arg Asp Ser Phe Ile 
    450                 455                 460                 


Ile Pro Val Val Pro Tyr Ser Val Ile Glu Glu Lys Arg Arg Ser Ser 
465                 470                 475                 480 


Lys Val Pro Val Ser Phe Glu Thr Phe Lys Asn Phe Lys Val Tyr Gly 
                485                 490                 495     


Cys Ile Val Ser Asp Glu Phe Val Ser Ala Glu Lys Leu Lys Cys Asn 
            500                 505                 510         


Leu Ser Ser Pro Lys Ala Leu Leu Arg Asp Met Ile Arg Lys Ser Ile 
        515                 520                 525             


Ala Ala Phe Val Val Asp Gly Asp Tyr Asp Ser Glu Met Gly Leu Val 
    530                 535                 540                 


Lys Arg 
545     


<210>  6
<211>  241
<212>  PRT
<213>  Archaeoglobus fulgidus


<220>
<221>  PROPEP
<222>  (1)..(241)
<223>  CRISPR-associated endonuclease Cas3':WP_010879368.1

<400>  6

Met Arg Ile Tyr Ser Phe Tyr Asn Glu Asn Ala Arg Arg Glu Thr Leu 
1               5                   10                  15      


Glu Glu His Val Ala Thr Ala Leu Lys Leu Leu Asp Ser Ala Glu Asn 
            20                  25                  30          


Ser Lys Leu Val Lys Tyr Gly Lys Lys Leu Ser Pro Glu Phe Glu Arg 
        35                  40                  45              


Ala Val Lys Leu Ala Ile Ile Phe His Asp Thr Gly Lys Val Phe Phe 
    50                  55                  60                  


Gln Ile Lys Lys Gly Tyr Gly Tyr Met Ser Phe Arg Gly His Glu Tyr 
65                  70                  75                  80  


Phe Ser Thr Tyr Ile Phe Asp Val Phe Ala Arg Arg Leu Ile Lys Ser 
                85                  90                  95      


Glu Ile Glu Asn Tyr Glu Ala Leu Ser Glu Leu Arg Lys Ile Cys Asn 
            100                 105                 110         


Phe Ser Ile Phe Phe His His His Ala Met Asn Ile Arg Met Arg Glu 
        115                 120                 125             


Pro Glu Ala Gly Ser Asn Ile Lys Ala Gly Leu Lys Leu Leu Asp Val 
    130                 135                 140                 


Leu Tyr Ser Glu Val Lys Arg Phe Leu Glu Asp Lys Glu Lys Lys Ala 
145                 150                 155                 160 


Leu Lys Ala Ala Leu Glu Glu Val Lys Glu Lys Gly Thr Ala Asn Leu 
                165                 170                 175     


Thr Gly Tyr Val Lys Gly Glu Ile Val Arg Glu Val Trp Arg Asn Ala 
            180                 185                 190         


Met Asp Ser Ser Lys Leu Lys Arg Leu Cys Tyr Leu Asn Leu Leu Val 
        195                 200                 205             


Leu Ile Ala Ala Asp Tyr Ser Ser Ala Ala Leu Asn Arg Gly Gly Asn 
    210                 215                 220                 


Lys Thr Pro Phe Gly Arg Val Val Glu Glu Phe Ser Glu Phe Tyr Leu 
225                 230                 235                 240 


Lys 
    


<210>  7
<211>  94
<212>  PRT
<213>  Archaeoglobus fulgidus


<220>
<221>  PEPTIDE
<222>  (1)..(94)
<223>  CRISPR-associated endonuclease Cas2: WP_010879369.1

<400>  7

Met Leu His Leu Val Val Tyr Asp Ile Ser Asp Asp Gly Ser Arg Ala 
1               5                   10                  15      


Arg Leu Ala Lys Leu Leu Glu Lys Phe Gly Leu Gln Arg Val Gln Tyr 
            20                  25                  30          


Ser Ala Phe Arg Gly Glu Leu Asn Pro Asn Asp Arg Glu Val Leu Ala 
        35                  40                  45              


Arg Gln Val Gly Lys Phe Val Arg Asp Asp Arg Asp Cys Ile Phe Ile 
    50                  55                  60                  


Ile Pro Leu Cys Gln Arg Cys Ser Ser Thr Ala Ile Val Ile Ser Asn 
65                  70                  75                  80  


Thr Gly Val Glu Leu Val Lys Glu Lys Gly Val Glu Phe Val 
                85                  90                  


<210>  8
<211>  189
<212>  PRT
<213>  Archaeoglobus fulgidus


<220>
<221>  PEPTIDE
<222>  (1)..(189)
<223>  CRISPR-associated protein Cas4: WP_010879370.1

<400>  8

Met Arg Gly Leu Phe Arg Ser Gly Lys Met Asp Val Ser Asp Ile Val 
1               5                   10                  15      


Gln Tyr Leu Tyr Cys Pro Arg Lys Leu Tyr Phe Leu Lys Ile Ala Gly 
            20                  25                  30          


Ile Arg Ile Ser Lys Pro Lys Met Glu Glu Gly Lys Ala Ala Gln Glu 
        35                  40                  45              


Glu Ala Arg Gly Lys Leu Arg Ser Phe Ala Arg Lys Leu Lys Gly Glu 
    50                  55                  60                  


Leu Leu Thr Ser Val Tyr Leu Glu Ser Lys Arg Tyr Gly Leu Lys Gly 
65                  70                  75                  80  


Val Leu Asp Ala Leu Val Ile Val Asp Gly Gly Ala Phe Pro Val Asp 
                85                  90                  95      


Val Lys Leu Thr Arg Phe Gln Ser Ile Thr Tyr Ala Trp Lys Met Gln 
            100                 105                 110         


Leu Thr Ala Tyr Ala Leu Leu Val Glu Glu Asn Tyr Ala Val Glu Val 
        115                 120                 125             


Arg Lys Gly Tyr Leu Phe Leu Leu Asn Gln Gly Lys Phe Val Glu Val 
    130                 135                 140                 


Ser Ile Ser Pro Asp Asp Arg Lys Ala Leu Leu Arg Ile Ile Lys Glu 
145                 150                 155                 160 


Ile Glu Arg Leu Ile Glu Glu Glu Lys Tyr Pro Arg Thr Ser Lys Ser 
                165                 170                 175     


Lys Lys Cys Gly Tyr Cys Glu Val Arg Glu Phe Cys Val 
            180                 185                 


<210>  9
<211>  345
<212>  PRT
<213>  Archaeoglobus fulgidus


<220>
<221>  PEPTIDE
<222>  (1)..(345)
<223>  CRISPR-associated protein Cas1: WP_010879371.1

<400>  9

Met Arg Leu Val Val Asp Gly Phe Gly Lys Tyr Leu Gly Ile Glu Asn 
1               5                   10                  15      


Gly Leu Ile Val Val Lys Glu Lys Gly Lys Ala Leu Arg Lys Val Arg 
            20                  25                  30          


Pro Glu Asp Leu Lys Gln Val Leu Ile Ile Gly Lys Ala Ala Ile Ser 
        35                  40                  45              


Ser Asp Ala Ile Lys Leu Leu Leu Lys Asn Arg Val Asp Val Val Phe 
    50                  55                  60                  


Leu Asp Phe Asn Gly Glu Ile Leu Gly Arg Leu Ser His Pro Leu Ile 
65                  70                  75                  80  


Gly Thr Ala Lys Thr Arg Arg Glu Gln Tyr Leu Ala Tyr Gly Asp Lys 
                85                  90                  95      


Arg Gly Val His Leu Ala Lys Glu Phe Ile Lys Ala Lys Met Ala Asn 
            100                 105                 110         


Gln Met Ala Ile Leu Thr Asn Leu Ala Lys Ala Arg Lys Asp Ser Asn 
        115                 120                 125             


Pro Glu Val Ala Glu Ser Leu Leu Lys Ala Lys Lys Glu Ile Asp Ala 
    130                 135                 140                 


Cys Leu Asn Glu Leu Asp Gly Val Glu Ala Glu Met Ile Asp Lys Val 
145                 150                 155                 160 


Arg Glu Arg Leu Leu Gly Ile Glu Gly Lys Ala Ser Lys His Tyr Trp 
                165                 170                 175     


Asp Ala Ile Ser Leu Val Ile Pro Glu Glu Tyr Arg Phe Asn Gly Arg 
            180                 185                 190         


Arg Gly Ile Glu Ile Gly Ser Pro Arg Tyr Ala Lys Asp Ile Val Asn 
        195                 200                 205             


Ala Met Leu Asn Tyr Gly Tyr Ser Ile Leu Leu Ala Glu Cys Val Lys 
    210                 215                 220                 


Ala Val Glu Leu Ala Gly Leu Asp Pro Tyr Ala Gly Phe Leu His Val 
225                 230                 235                 240 


Asp Val Ser Gly Arg Ser Ser Leu Ala Ile Asp Leu Met Glu Asn Phe 
                245                 250                 255     


Arg Gln Gln Val Val Asp Arg Val Val Leu Arg Leu Ile Ser Tyr Arg 
            260                 265                 270         


Gln Ile Lys Pro Glu Asp Cys Glu Lys Arg Asn Met Val Cys Gln Leu 
        275                 280                 285             


Ser Asp Asn Ala Arg Arg Leu Leu Leu Ala Ser Leu Leu Glu Arg Leu 
    290                 295                 300                 


Asp Ser Lys Thr Gln Tyr Arg Gly Arg Asn Leu Ala Tyr Ser Ser Ile 
305                 310                 315                 320 


Ile Leu Leu His Ala Arg Asp Val Val Ala Phe Leu Arg Gly Glu Arg 
                325                 330                 335     


Arg Tyr Glu Gly Phe Val Gln Lys Trp 
            340                 345 


<210>  10
<211>  281
<212>  PRT
<213>  Archaeoglobus fulgidus


<220>
<221>  PEPTIDE
<222>  (1)..(281)
<223>  type I-A CRISPR-associated protein Cas4/Csa1: WP_010879372.1

<400>  10

Met Val Tyr Phe Leu Asn Glu Leu Glu His Lys Phe Leu Thr Leu Glu 
1               5                   10                  15      


Leu Arg Pro Arg Ile Arg Gln Asn Pro Val Pro Glu Glu Leu Arg Gly 
            20                  25                  30          


Trp Asn Trp His Ser Pro Pro Leu Lys Pro Tyr Tyr Asn Val Lys Leu 
        35                  40                  45              


Pro Met Tyr Leu Ile Cys Ser Arg Tyr Cys Pro Thr Ser Arg Asp Val 
    50                  55                  60                  


Tyr Leu Thr Met Val Glu Lys Val Arg Gly Glu Glu Ser Phe Pro Val 
65                  70                  75                  80  


Ser Leu Gly Lys Ala Ile His Glu Ala Val Ala Lys Ala Ile Arg Glu 
                85                  90                  95      


Ala Lys Ser Lys Asn Phe Ser Ala Glu Pro Pro Asn Tyr Asp Asn Glu 
            100                 105                 110         


Met Ile Asn Val Ala Val Lys Ala Val Trp Glu Tyr Thr Met Ser Leu 
        115                 120                 125             


Cys Gln Ser Ser Tyr Leu Lys Val Arg Ser Glu Gln Pro Tyr Ala Thr 
    130                 135                 140                 


Glu Glu Gly Val Leu Leu Thr Ser Met Pro Phe Leu Val Glu His Arg 
145                 150                 155                 160 


Met Asp Gly Ser Leu Leu Gly Cys Ser Gly Leu Ile Ser Val Asp Cys 
                165                 170                 175     


Tyr Asp Tyr Leu Arg Asn Val Val Phe Asp Leu Lys Val Gly Glu Phe 
            180                 185                 190         


Asn Glu Glu Met Arg Leu Tyr Thr Thr Gly Tyr Ala Leu Val Leu Glu 
        195                 200                 205             


Ser Ile His Glu Ile Pro Val Asp Val Gly Cys Ile Ile Ser Ile Thr 
    210                 215                 220                 


Phe Asn Gly Glu Arg Met Arg Val Ser Lys Asp Leu His Tyr Ile Asp 
225                 230                 235                 240 


Ala Asn Leu Arg Ser Trp Trp Ile Glu Glu Arg Asp Arg Lys Ala Glu 
                245                 250                 255     


Ile Val Phe Asn Glu Ala Asp Pro Gly Val Ala Lys Ser Cys Ser Ser 
            260                 265                 270         


Asn Cys Leu Phe Asn Ala Phe Cys Leu 
        275                 280     


<210>  11
<211>  172
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(172)
<223>  CRISPR-associated Cas4 family protein: YP_001089495.1

<400>  11

Met Pro Ile Asp Leu Glu Val Leu Lys Val Gln Gly Val Lys Ile Asn 
1               5                   10                  15      


Tyr Tyr Tyr Val Cys Lys Arg Lys Leu Trp Leu Phe Ser Lys Gly Ile 
            20                  25                  30          


Thr Met Glu Gln Asn Ser Ser Arg Val Leu Ser Gly Lys Ile Val His 
        35                  40                  45              


Glu Asp Ser Tyr Lys Arg Met Lys Asn Lys Glu Ile Leu Ile Asp Asp 
    50                  55                  60                  


Ile Leu Lys Leu Asp Ile Ile Lys Asp Glu Tyr Val Lys Glu Val Lys 
65                  70                  75                  80  


Ile Ser Ser Lys Met Lys Glu Ala Asp Glu Met Gln Leu Tyr Tyr Tyr 
                85                  90                  95      


Leu Tyr Tyr Leu Lys Asn Ser Met Gly Ile Glu Lys Lys Gly Thr Ile 
            100                 105                 110         


Asn Tyr Val Lys Glu Lys Lys Gln Glu Glu Leu Ile Leu Thr Glu Glu 
        115                 120                 125             


Lys Glu Arg Ile Ile Glu Asn Thr Leu Ile Asn Ile Asn Glu Ile Asn 
    130                 135                 140                 


Met Gln Leu Ser Pro Pro Lys Ile Glu Lys Lys His Tyr Cys Thr Lys 
145                 150                 155                 160 


Cys Ala Tyr Tyr Glu Phe Cys Phe Val Lys Glu Glu 
                165                 170         


<210>  12
<211>  245
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(245)
<223>  CRISPR/Cas system-associated RAMP superfamily protein Cas6: 
       YP_001089500.1

<400>  12

Met Lys Met Lys Ile Glu Phe Ser Thr Gly Cys Ile Pro Ile Ser Tyr 
1               5                   10                  15      


Asn Ser Leu Phe Met Ser Ile Ile Lys Glu Ala Ile Arg Lys Ser Asn 
            20                  25                  30          


Glu Asp Tyr Tyr Lys Asn Met Tyr Tyr Tyr Lys Glu Lys Asn Asn Lys 
        35                  40                  45              


Lys Thr Lys Asn Phe Thr Phe Ser Val Tyr Ile Lys Lys Tyr Ser Ile 
    50                  55                  60                  


Glu Gly Asp Asn Phe Ile Ile Glu Asp Lys Val Ile Leu Asn Ile Ser 
65                  70                  75                  80  


Thr Pro Asp Leu Glu Leu Gly Phe His Ile Tyr Asn Gly Leu Met Thr 
                85                  90                  95      


Ser Lys Lys Cys Leu Tyr Lys Asp Tyr Glu Leu Thr Arg Ile Arg Ile 
            100                 105                 110         


Asp Leu Ser Arg Glu Lys Lys Val Thr Glu Glu Arg Val Leu Phe Asn 
        115                 120                 125             


Ala Leu Ser Pro Ile Cys Val Lys Ser Lys Glu Gly Lys Phe Leu Glu 
    130                 135                 140                 


Ile Thr Asp Asp Arg Tyr Ile Glu Glu Leu Asn Tyr Ile Thr Asn Glu 
145                 150                 155                 160 


Val Val Lys Asn Tyr Arg Gly Asn Gly Leu Lys Arg Lys Leu Glu Phe 
                165                 170                 175     


Glu Asn Val Gly Phe Lys Lys Val Val Val Lys Glu Ser Leu Arg Glu 
            180                 185                 190         


Phe Lys Lys Ile Thr Gly Lys Glu Tyr Gln Tyr Ile Asn Gly Tyr Lys 
        195                 200                 205             


Gly Lys Phe Ile Leu Lys Gly Asp Ile Asp Asp Leu Asn Leu Ile Tyr 
    210                 215                 220                 


Asn Leu Gly Ile Gly Phe Arg Arg Ala Gln Gly Phe Gly Asp Val Asp 
225                 230                 235                 240 


Ile Leu Glu Trp Arg 
                245 


<210>  13
<211>  625
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(625)
<223>  CRISPR-associated protein YP_001089499.1

<400>  13

Met Lys Leu Arg Val Tyr Arg Gly Asp Trp Phe Phe Asn Met Gly Ile 
1               5                   10                  15      


Val Gly Phe Leu Asn Ile Ile Lys Lys Ala Asp Lys Gln Ala Glu Ile 
            20                  25                  30          


Phe Ile Met Glu Asp Tyr Ile Glu Phe Asp Ser Leu Phe Leu Glu Asn 
        35                  40                  45              


Phe His Glu Tyr Tyr Phe Asn Tyr Phe Met Asp Glu Tyr Asp Val Ser 
    50                  55                  60                  


Lys Arg Ile Lys Lys Asn Ile Asp Tyr Ser Ile Asn Phe Ile Lys Ser 
65                  70                  75                  80  


Lys Pro Asp Arg Ile Lys Asp Gly Ile Lys Lys Ile Lys Asp Ser Val 
                85                  90                  95      


Lys Gln Gln Asn Asp Lys Ile Lys Lys Phe Asp Glu Glu Lys Phe Asn 
            100                 105                 110         


Leu Ile Lys Glu Lys Leu Asp Ser Met Ser Lys Ile Lys Ser Tyr Asp 
        115                 120                 125             


Glu Phe Asp Ser Leu Glu Ala Leu Val Asp Glu Thr Ile Asp Ile Phe 
    130                 135                 140                 


Lys Ile Lys Ser Ile Asn Asp Arg Leu Thr Ala Asn Leu Tyr Lys Tyr 
145                 150                 155                 160 


Val Val Gln Asp Asn Tyr Phe Gly Gln Val Ser Phe Phe Asn Val Ala 
                165                 170                 175     


Lys Ala Lys Leu Asp Leu Asp Gly Leu Lys Gln Val Met Phe Asn Asp 
            180                 185                 190         


Tyr Leu Arg Gln Ile Ile Tyr Phe Gly Glu Leu Glu Asp Leu Leu Glu 
        195                 200                 205             


Glu Asn Asp Tyr Asp Lys Leu Lys Asn Tyr Leu Asn Asp Arg Leu Asn 
    210                 215                 220                 


Ser Ile Asp Lys Asp Ile Asn Glu Lys Lys Val Ser Lys Ser Ser Ile 
225                 230                 235                 240 


Asn Thr Ile Glu Lys Ile Met Lys Glu Ile Asn Lys Asn Phe Ile Lys 
                245                 250                 255     


Lys Asn Lys Ser Ile Glu Asp Ile Lys Glu Tyr Met Asp Ser Leu Glu 
            260                 265                 270         


Val Cys Glu Met Cys Gly Leu Tyr Lys Gly Ile Leu Asp Glu Tyr Ser 
        275                 280                 285             


Glu Ser Asn Phe Ala Pro Leu Gly Val Ser Thr Asn Asn Ala Arg Asn 
    290                 295                 300                 


Met Phe Trp Asn Gln Ala Tyr Val Pro Ser Ile Cys Asp Ile Cys Lys 
305                 310                 315                 320 


Leu Ile Leu Phe Cys Thr Pro Ala Gly Ala Thr Tyr Thr Arg Lys Asn 
                325                 330                 335     


Tyr Leu Ile Asn Glu Glu Asn Glu Phe Tyr Leu Phe Val Asn Met Asp 
            340                 345                 350         


Thr Cys Ile Asn Glu Leu Phe Glu Arg Asn Asn Ser Leu Lys Val Gln 
        355                 360                 365             


Lys Ser Glu Ser Ser Asp Ser Lys Asp Glu Asn Pro Phe Asn Gln Leu 
    370                 375                 380                 


Ile Lys Ser Ile Val Glu Glu Asn Thr Leu Lys Ser Glu Trp Gln Leu 
385                 390                 395                 400 


Arg Asn Ile Leu Phe Val Glu Phe Lys Ala Ser Ile Asp Ser Lys Lys 
                405                 410                 415     


Cys Lys Ile Asn Tyr Phe Asn Ile Pro Thr Tyr Leu Ala Lys Phe Phe 
            420                 425                 430         


Thr Asp Lys Tyr Ala Asn Lys Lys Ile Gln Ser Ile Tyr Asp Tyr Lys 
        435                 440                 445             


Leu Lys Ser Asn Val Leu Asp Leu Leu Leu Lys Asn Arg Asp Leu Lys 
    450                 455                 460                 


His Ile Thr Asn Asn Ile Leu Arg Asn Lys Val Lys Asn Asp Met Glu 
465                 470                 475                 480 


Ser Asn Asn Lys Ser Asn Ile Ser Gly Ile Asp Cys Phe Arg Val Val 
                485                 490                 495     


Gln Leu Arg Val Leu Ile Asn Ser Tyr Lys Lys Gly Val Tyr Lys Met 
            500                 505                 510         


Asp Ser Lys Asn Leu Glu Lys Asn Asp Glu Lys Leu Lys Ile Ile Tyr 
        515                 520                 525             


Tyr Leu Gly Cys Asp Ile His Asp Tyr Phe Val Asn Lys Asn Ser Lys 
    530                 535                 540                 


Asn Lys Ile Asp Gly Val Ser Tyr Lys Leu Leu Asn Ser Val Lys Val 
545                 550                 555                 560 


Gly Asn Lys Ser Asp Phe Met Asp Thr Ile Ile Arg Val Phe Met Ser 
                565                 570                 575     


Ala Glu Lys Gln Ile Pro Ala Phe Ile Leu Asp Ile Glu Ile Glu Lys 
            580                 585                 590         


Asp Leu Asp Phe Glu Ser Ile Gly His Ala Phe Ile Ser Gly Leu Ile 
        595                 600                 605             


Ser Gly Lys Tyr Glu Gly Lys Asp Lys Leu Pro Asn Glu Lys Glu Glu 
    610                 615                 620                 


Lys 
625 


<210>  14
<211>  304
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(304)
<223>  CRISPR-associated autoregulator DevR family:YP_001089498.1

<400>  14

Met Lys Arg Gly Leu Thr Phe Thr Val Ile Ala Gln Ala Gln Ser Leu 
1               5                   10                  15      


Asn Tyr Gly Glu Gly Ile Gly Asn Ile Ser Glu Leu Lys Lys Leu Ser 
            20                  25                  30          


Arg Asp Asp Gly Asn Met Tyr Thr Phe Ala Ser Arg Gln Cys Leu Arg 
        35                  40                  45              


Tyr Asp Ile Val Arg Leu Ala Ala Glu Leu Phe Asn Trp Asn Leu Gln 
    50                  55                  60                  


Val Val Asp Lys Glu Lys Gly Thr Ile Gln Phe Lys Asp Asn Ile Ser 
65                  70                  75                  80  


Ile Arg Glu Ser Glu Glu Met Asp Leu Phe Gly Tyr Met Lys Thr Asn 
                85                  90                  95      


Lys Lys Asp Glu Lys Asp Lys Lys Gly Gly Ser Leu Thr Arg Glu Ala 
            100                 105                 110         


Thr Val Arg Leu Ser Asn Ala Ile Ser Leu Glu Pro Tyr Arg Ser Asp 
        115                 120                 125             


Met Asp Phe Leu Asn Asn Lys Gly Phe Ala Asp Arg Ile Gly Glu His 
    130                 135                 140                 


Pro Asn Leu Ala Asn Ile Glu Gln His Leu Ser Tyr Tyr Thr Tyr Thr 
145                 150                 155                 160 


Val Thr Ile Asp Leu Ser Lys Ile Gly Lys Asp Gly Glu Ile Glu Leu 
                165                 170                 175     


Asp Asn Lys Glu Lys Cys Arg Arg Val Val Glu Phe Leu Glu Ile Ile 
            180                 185                 190         


Lys Val Leu Asn Arg Asn Ile Arg Gly Arg Gln Glu Asn Leu Ser Pro 
        195                 200                 205             


Leu Phe Val Val Gly Gly Val Tyr Glu Ile Ala Asn Pro Phe Phe Leu 
    210                 215                 220                 


Gly Arg Ile Lys Leu Lys Gly Asp Lys Asn Gly Phe Lys Ile Asn Lys 
225                 230                 235                 240 


Gln Ala Ile Glu Glu Val Ile Gln Gly Thr Phe Leu Gly Lys Asp Leu 
                245                 250                 255     


Lys Glu Phe Thr Tyr Val Gly Met Val Asp Gly Val Phe Ile Asn Lys 
            260                 265                 270         


Glu Glu Phe Lys Gly Leu Phe Glu Asp Asn Phe Leu Ser Val Asp Lys 
        275                 280                 285             


Phe Phe Gly Gln Leu Val Lys Glu Val Lys Glu Tyr Tyr Gly Val Asn 
    290                 295                 300                 


<210>  15
<211>  773
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(773)
<223>  CRISPR-associated Cas3 family helicase: YP_001089496.1

<400>  15

Met Leu Tyr Ala Lys Ser Asn Pro Val Glu Thr Leu Arg Glu His Thr 
1               5                   10                  15      


Asp Glu Leu Leu Lys Gln Met Asn Val Leu Arg Glu Ser Tyr Gly Lys 
            20                  25                  30          


Asn Ile Asn Ser Leu Asp Phe Leu Glu Glu Glu Ile Phe Trp Gln Leu 
        35                  40                  45              


Leu Asp Phe Val Ile Glu Phe His Asp Ile Gly Lys Ala Phe Ser Pro 
    50                  55                  60                  


Phe Gln Glu Leu Ile Lys Ser Arg Met Asp Thr Lys Ile Asn Glu Pro 
65                  70                  75                  80  


Lys Ile Val Thr His Leu Glu Asn Asn Val Gly His Asn Tyr Leu Ser 
                85                  90                  95      


Pro Ala Phe Ile Asp Tyr Ser Tyr Ile Asp Arg Lys Lys Asn Lys Glu 
            100                 105                 110         


Leu Arg Ala Val Leu Asn Gln Val Ile Val Tyr His His Glu Arg Asp 
        115                 120                 125             


Ile Phe Ile Asp Lys Asp Phe Lys Asn Leu Ile Gln Lys Ile Leu Asp 
    130                 135                 140                 


Glu Asp Leu Ile Asn Lys Val Tyr Glu Leu Gln His Glu Phe Lys Val 
145                 150                 155                 160 


Arg Tyr Pro Ile Lys Thr Glu Lys Leu Ser Lys Val Tyr Leu Gln Ser 
                165                 170                 175     


Val Glu Lys Arg Ile Asp Lys Asn His Lys Tyr Tyr Asn Leu Tyr Ile 
            180                 185                 190         


Met Leu Lys Gly Ile Leu His Arg Leu Asp His Ser Ala Ser Ala His 
        195                 200                 205             


Glu Val Val Glu Cys Asn Asn Val Ile Asn Ile Gly Glu Gln Thr Glu 
    210                 215                 220                 


Asn Tyr Leu Met Lys Glu Phe Gly Ser Leu Arg Glu Ala Gln Ser Phe 
225                 230                 235                 240 


Ala Lys Ser Asn Arg Asn Lys Asn Ile Ile Leu Ile Ala Pro Thr Gly 
                245                 250                 255     


Met Gly Lys Thr Glu Thr Ala Leu Ile Trp Ile Asp Lys Asp Lys Ala 
            260                 265                 270         


Phe Phe Thr Leu Pro Leu Arg Val Ser Ile Asn Ala Leu Phe Asp Arg 
        275                 280                 285             


Ala Lys Asn Ile Val Gly Val Gly Glu Ser Asn Asp Thr Phe Leu Gly 
    290                 295                 300                 


Leu Leu His Ser Thr Ala Ile Asp Tyr Leu Glu Glu Ser Asn Gln Glu 
305                 310                 315                 320 


Asn Ser Ser Glu Ile Val Asp Leu Ala Lys Leu Leu Ser Cys Lys Leu 
                325                 330                 335     


Thr Phe Ser Thr Ile Asp Gln Ile Phe Lys Phe Pro Phe Leu Tyr Arg 
            340                 345                 350         


Gly Tyr Glu Lys Val Tyr Ser Thr Leu Ala Tyr Ser Lys Val Val Ile 
        355                 360                 365             


Asp Glu Ile Gln Ala Tyr Ser Pro Glu Ile Ala Ala Val Leu Val Lys 
    370                 375                 380                 


Gly Ile Glu Met Ile His Lys Ile Gly Gly Arg Phe Met Ile Met Thr 
385                 390                 395                 400 


Ala Thr Met Pro Thr Ile Tyr Ile Asp Glu Leu Lys Lys Arg Gly Val 
                405                 410                 415     


Met Asn Ser Asn Leu Ala Glu Leu Thr Cys Asn Thr Glu Lys Ile Arg 
            420                 425                 430         


His Cys Val Ser Ile Val Glu Asn Ser Ile Asp Glu Asn Leu Gly Lys 
        435                 440                 445             


Ile Ile Gln Ser Gly Met Asn Lys Lys Val Leu Val Ile Val Asn Thr 
    450                 455                 460                 


Val Lys Ser Ala Val Glu Lys Tyr Glu Leu Ile Glu Glu Ile Val Lys 
465                 470                 475                 480 


Pro Lys Gly Ile Asp Val Asn Leu Asn Leu Leu His Ser Met Tyr Ile 
                485                 490                 495     


Gln Glu Asp Arg Ala Lys Leu Glu Lys Tyr Ile Lys Glu Phe Ala Asp 
            500                 505                 510         


Ser Asp Ser Asn Gly Ile Trp Ile Thr Thr Gln Leu Val Glu Ala Ser 
        515                 520                 525             


Leu Asp Ile Asp Phe Asp Glu Leu His Thr Glu Asn Ser Thr Leu Asp 
    530                 535                 540                 


Ser Leu Phe Gln Arg Phe Gly Arg Cys Tyr Arg Ser Arg Glu Tyr Glu 
545                 550                 555                 560 


Glu Asn Ser Pro Asn Ile Phe Ile Tyr Thr Glu Lys Ala Thr Gly Ile 
                565                 570                 575     


Gly Ser Ile Tyr Asp Lys Asp Ile Val Glu Lys Gly Leu Glu Leu Leu 
            580                 585                 590         


Lys Thr Phe Ile Asn Gly Lys Glu Cys Val Lys Met Lys Glu Lys Tyr 
        595                 600                 605             


Lys Val Glu Met Val Lys Ile Leu Tyr Ser Lys Glu Ser Leu Glu Gly 
    610                 615                 620                 


Thr Ala Phe Glu Lys Arg Phe Thr Ser Ala Leu Asn Ile Leu Asp Thr 
625                 630                 635                 640 


Ile Thr Pro Tyr Ser Leu Gly Ser Lys Asp Ala Gln Asn Ile Leu Arg 
                645                 650                 655     


Asn Ile Glu Gly Tyr Thr Val Ile Pro Glu Asp Ile Tyr Asn Lys Ile 
            660                 665                 670         


Glu Glu Thr Leu Ile Lys Asp Tyr Glu Glu Leu Gly Gln Glu Leu Ile 
        675                 680                 685             


Asn Ala Tyr Ser Asn Asp Asp Arg Gln Leu Ile Asn Lys Ile Lys Ser 
    690                 695                 700                 


Lys Arg Lys Lys Ala Arg Arg Glu Ile Ile Lys Lys Thr Val Asn Leu 
705                 710                 715                 720 


Pro Ile Tyr Lys Ala Lys Gln Asn Val Ile Asp Ile Gln Val Lys Gly 
                725                 730                 735     


Leu Glu Asp Leu Lys Ile Leu Leu Tyr Lys Tyr Asp Ile Tyr Glu Asn 
            740                 745                 750         


Lys His Thr Lys Gln Ile Phe Gly Lys Gly Val Leu Ile Ser Asn Glu 
        755                 760                 765             


Ile Asp Gln Phe Ile 
    770             


<210>  16
<211>  233
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(233)
<223>  CRISPR-associated Cas5 family protein:YP_001089497.1

<400>  16

Met Lys Val Leu Lys Leu Asp Leu Phe Gln Glu Thr Ala Cys Tyr Lys 
1               5                   10                  15      


Lys Pro Phe Ala Met Lys Ile Thr Glu Thr Tyr Pro Leu Pro Pro Tyr 
            20                  25                  30          


Ser Thr Ile Asn Gly Leu Ile His Lys Ile Leu Asn Ala Thr Glu Tyr 
        35                  40                  45              


Ile Pro Phe Asn Ile Ser Val Gln Gly Thr Tyr Glu Ser Ile Phe Asn 
    50                  55                  60                  


Asn Tyr Gln Thr Thr Tyr Phe Tyr Lys Lys Asp Ser Ile Thr Ser Met 
65                  70                  75                  80  


Pro Met Asn Ser His Met Leu Leu Asn Val Asn Leu Ile Ile His Ile 
                85                  90                  95      


Gly Gly Asp Phe Asp Leu Leu Glu Glu Ile Tyr Asp Ser Leu Leu Asn 
            100                 105                 110         


Tyr Asp Glu His Leu Ser Leu Gly Arg Lys Glu Asp Leu Val Arg Ile 
        115                 120                 125             


Asn Asp Ile Arg Phe Val Glu Val Asn Lys Phe Glu Val Asp Glu Asp 
    130                 135                 140                 


Ile Gln Leu Asp Asp Tyr Glu Asn Tyr Lys Leu Ser Glu Cys Asn Ile 
145                 150                 155                 160 


Arg Met Pro Ile Tyr Ile Pro Lys Thr Ser Leu Gln Asp Thr Asp Ile 
                165                 170                 175     


Asp Gly Ile Ser Tyr Arg Leu Asn Asn Tyr Tyr Asp Asn Asn Ala Val 
            180                 185                 190         


Glu Asp Lys Lys Arg Val Trp Asn Lys Val Asp Ser Tyr Tyr Val Glu 
        195                 200                 205             


Asp Gly Asn Thr Ile Ser Ile Gly Asp Ile Leu Leu Asp Asn Glu Gly 
    210                 215                 220                 


Asp Leu Leu Tyr Phe Asn Asn Ile Asn 
225                 230             


<210>  17
<211>  800
<212>  PRT
<213>  Bacillus halodurans


<220>
<221>  PEPTIDE
<222>  (1)..(800)
<223>  CRISPR/Cas system-associated endonuclease/helicase [Cas3]: 
       WP_010896517

<400>  17

Met Tyr Ile Ala His Ile Arg Glu Val Asp Lys Val Ile Gln Thr Leu 
1               5                   10                  15      


Lys Glu His Leu Cys Gly Val Gln Cys Leu Ala Glu Thr Phe Gly Ala 
            20                  25                  30          


Lys Leu Arg Leu Gln His Val Ala Gly Leu Ala Gly Leu Leu His Asp 
        35                  40                  45              


Leu Gly Lys Tyr Thr Asn Glu Phe Lys Asp Tyr Ile Tyr Lys Ala Val 
    50                  55                  60                  


Phe Glu Pro Glu Leu Ala Glu Lys Lys Arg Gly Gln Val Asp His Ser 
65                  70                  75                  80  


Thr Ala Gly Gly Arg Leu Leu Tyr Gln Met Leu His Asp Arg Glu Asn 
                85                  90                  95      


Ser Phe His Glu Lys Leu Leu Ala Glu Val Val Gly Asn Ala Ile Ile 
            100                 105                 110         


Ser His His Ser Asn Leu Gln Asp Tyr Ile Ser Pro Thr Ile Glu Ser 
        115                 120                 125             


Asn Phe Leu Thr Arg Val Leu Glu Lys Glu Leu Pro Glu Tyr Glu Ser 
    130                 135                 140                 


Ala Val Glu Arg Phe Phe Gln Glu Val Met Thr Glu Ala Glu Leu Ala 
145                 150                 155                 160 


Arg Tyr Val Ala Lys Ala Val Asp Glu Ile Lys Gln Phe Thr Asp Asn 
                165                 170                 175     


Ser Pro Thr Gln Ser Phe Phe Leu Thr Lys Tyr Ile Phe Ser Cys Leu 
            180                 185                 190         


Ile Asp Ala Asp Arg Thr Asn Thr Arg Met Phe Asp Glu Gln Ala Arg 
        195                 200                 205             


Glu Glu Glu Pro Thr Gln Pro Gln Gln Leu Phe Glu His Tyr His Gln 
    210                 215                 220                 


Gln Leu Leu Asn His Leu Ala Ser Leu Lys Glu Ser Asp Ser Ala Gln 
225                 230                 235                 240 


Lys Pro Ile Asn Val Leu Arg Ser Ala Met Ser Glu Gln Cys Glu Ser 
                245                 250                 255     


Phe Ala Met Arg Pro Ser Gly Ile Tyr Thr Leu Ser Ile Pro Thr Gly 
            260                 265                 270         


Gly Gly Lys Thr Leu Ala Ser Leu Arg Tyr Ala Leu Lys His Ala Gln 
        275                 280                 285             


Glu Tyr Asn Lys Gln Arg Ile Ile Tyr Ile Val Pro Phe Thr Thr Ile 
    290                 295                 300                 


Ile Glu Gln Asn Ala Gln Glu Val Arg Asn Ile Leu Gly Asp Asp Glu 
305                 310                 315                 320 


Asn Ile Leu Glu His His Ser Asn Val Val Glu Asp Ser Glu Asn Gly 
                325                 330                 335     


Asp Glu Gln Glu Asp Gly Val Ile Thr Lys Lys Glu Arg Leu Arg Leu 
            340                 345                 350         


Ala Arg Asp Asn Trp Asp Arg Pro Ile Ile Phe Thr Thr Leu Val Gln 
        355                 360                 365             


Phe Leu Asn Val Phe Tyr Ala Lys Gly Asn Arg Asn Thr Arg Arg Leu 
    370                 375                 380                 


His Asn Leu Ser His Ser Val Leu Ile Phe Asp Glu Val Gln Lys Val 
385                 390                 395                 400 


Pro Thr Lys Cys Val Ser Leu Phe Asn Glu Ala Leu Asn Phe Leu Lys 
                405                 410                 415     


Glu Phe Ala His Cys Ser Ile Leu Leu Cys Thr Ala Thr Gln Pro Thr 
            420                 425                 430         


Leu Glu Asn Val Lys His Ser Leu Leu Lys Asp Arg Asp Gly Glu Ile 
        435                 440                 445             


Val Gln Asn Leu Thr Glu Val Ser Glu Ala Phe Lys Arg Val Glu Ile 
    450                 455                 460                 


Leu Asp Lys Thr Asp Gln Pro Met Thr Asn Glu Arg Leu Ala Glu Trp 
465                 470                 475                 480 


Val Arg Asp Glu Ala Pro Ser Trp Gly Ser Thr Leu Ile Ile Leu Asn 
                485                 490                 495     


Thr Lys Lys Val Val Lys Asp Leu Tyr Glu Lys Leu Glu Gly Gly Pro 
            500                 505                 510         


Leu Pro Val Phe His Leu Ser Thr Ser Met Cys Ala Ala His Arg Lys 
        515                 520                 525             


Asp Gln Leu Asp Glu Ile Arg Ala Leu Leu Lys Glu Gly Thr Pro Phe 
    530                 535                 540                 


Ile Cys Val Thr Thr Gln Leu Ile Glu Ala Gly Val Asp Val Ser Phe 
545                 550                 555                 560 


Lys Cys Val Ile Arg Ser Leu Ala Gly Leu Asp Ser Ile Ala Gln Ala 
                565                 570                 575     


Ala Gly Arg Cys Asn Arg His Gly Glu Glu Gln Leu Gln Tyr Val Tyr 
            580                 585                 590         


Val Ile Asp His Ala Glu Glu Thr Leu Ser Lys Leu Lys Glu Ile Glu 
        595                 600                 605             


Val Gly Gln Glu Ile Ala Gly Asn Val Leu Ala Arg Phe Lys Lys Lys 
    610                 615                 620                 


Ala Glu Lys Tyr Glu Gly Asn Leu Leu Ser Gln Ala Ala Met Arg Glu 
625                 630                 635                 640 


Tyr Phe Arg Tyr Tyr Tyr Ser Lys Met Asp Ala Asn Leu Asn Tyr Phe 
                645                 650                 655     


Val Lys Glu Val Asp Lys Asp Met Thr Lys Leu Leu Met Ser His Ala 
            660                 665                 670         


Val Glu Asn Ser Tyr Val Thr Tyr Tyr Gln Lys Asn Thr Gly Thr His 
        675                 680                 685             


Phe Pro Leu Leu Leu Asn Gly Ser Tyr Lys Thr Ala Ala Asp His Phe 
    690                 695                 700                 


Arg Val Ile Asp Gln Asn Thr Thr Ser Ala Ile Val Pro Tyr Gly Glu 
705                 710                 715                 720 


Gly Gln Asp Ile Ile Ala Gln Leu Asn Ser Gly Glu Trp Val Asp Asp 
                725                 730                 735     


Leu Ser Lys Val Leu Lys Lys Ala Gln Gln Tyr Thr Val Asn Leu Tyr 
            740                 745                 750         


Ser Gln Glu Ile Asp Gln Leu Lys Lys Glu Gly Ala Ile Val Met His 
        755                 760                 765             


Leu Asp Gly Met Val Tyr Glu Leu Lys Glu Ser Trp Tyr Ser His Gln 
    770                 775                 780                 


Tyr Gly Val Asp Phe Lys Gly Glu Gly Gly Met Asp Phe Met Ser Phe 
785                 790                 795                 800 


<210>  18
<211>  236
<212>  PRT
<213>  Bacillus halodurans


<220>
<221>  PEPTIDE
<222>  (1)..(236)
<223>  CRISPR/Cas system-associated protein Cas5: WP_010896518.1

<400>  18

Met Arg Asn Glu Val Gln Phe Glu Leu Phe Gly Asp Tyr Ala Leu Phe 
1               5                   10                  15      


Thr Asp Pro Leu Thr Lys Ile Gly Gly Glu Lys Leu Ser Tyr Ser Val 
            20                  25                  30          


Pro Thr Tyr Gln Ala Leu Lys Gly Ile Ala Glu Ser Ile Tyr Trp Lys 
        35                  40                  45              


Pro Thr Ile Val Phe Val Ile Asp Glu Leu Arg Val Met Lys Pro Ile 
    50                  55                  60                  


Gln Met Glu Ser Lys Gly Val Arg Pro Ile Glu Tyr Gly Gly Gly Asn 
65                  70                  75                  80  


Thr Leu Ala His Tyr Thr Tyr Leu Lys Asp Val His Tyr Gln Val Lys 
                85                  90                  95      


Ala His Phe Glu Phe Asn Leu His Arg Pro Asp Leu Ala Phe Asp Arg 
            100                 105                 110         


Asn Glu Gly Lys His Tyr Ser Ile Leu Gln Arg Ser Leu Lys Ala Gly 
        115                 120                 125             


Gly Arg Arg Asp Ile Phe Leu Gly Ala Arg Glu Cys Gln Gly Tyr Val 
    130                 135                 140                 


Ala Pro Cys Glu Phe Gly Ser Gly Asp Gly Phe Tyr Asp Gly Gln Gly 
145                 150                 155                 160 


Lys Tyr His Leu Gly Thr Met Val His Gly Phe Asn Tyr Pro Asp Glu 
                165                 170                 175     


Thr Gly Gln His Gln Leu Asp Val Arg Leu Trp Ser Ala Val Met Glu 
            180                 185                 190         


Asn Gly Tyr Ile Gln Phe Pro Arg Pro Glu Asp Cys Pro Ile Val Arg 
        195                 200                 205             


Pro Val Lys Glu Met Glu Pro Lys Ile Phe Asn Pro Asp Asn Val Gln 
    210                 215                 220                 


Ser Ala Glu Gln Leu Leu His Asp Leu Gly Gly Glu 
225                 230                 235     


<210>  19
<211>  627
<212>  PRT
<213>  Bacillus halodurans


<220>
<221>  PEPTIDE
<222>  (1)..(627)
<223>  CRISPR/Cas system-associated protein Cas8C/Csd1 : WP_010896519.1

<400>  19

Met Ser Trp Leu Leu His Leu Tyr Glu Thr Tyr Glu Ala Asn Leu Asp 
1               5                   10                  15      


Gln Val Gly Lys Thr Val Lys Lys Gly Glu Asp Arg Glu Tyr Thr Leu 
            20                  25                  30          


Leu Pro Ile Ser His Thr Thr Gln Asn Ala His Ile Glu Val Thr Leu 
        35                  40                  45              


Asp Glu Asp Gly Asp Phe Leu Arg Ala Lys Ala Leu Thr Lys Glu Ser 
    50                  55                  60                  


Thr Leu Ile Pro Cys Thr Glu Glu Ala Ala Ser Arg Ser Gly Ser Lys 
65                  70                  75                  80  


Val Ala Pro Tyr Pro Leu His Asp Lys Leu Ser Tyr Val Ala Gly Asp 
                85                  90                  95      


Phe Val Lys Tyr Gly Gly Lys Ile Lys Asn Gln Asp Asp Ala Pro Phe 
            100                 105                 110         


Asp Thr Tyr Ile Lys Asn Leu Gly Glu Trp Ala Asn Ser Pro Tyr Ala 
        115                 120                 125             


Thr Glu Lys Val Lys Cys Ile Tyr Thr Tyr Leu Lys Lys Gly Arg Leu 
    130                 135                 140                 


Ile Glu Asp Leu Val Asp Ala Gly Val Leu Lys Leu Asp Glu Asn Gln 
145                 150                 155                 160 


Gln Leu Ile Glu Lys Trp Glu Lys Arg Tyr Glu Glu Leu Leu Gly Glu 
                165                 170                 175     


Lys Pro Ala Ile Phe Ser Ser Gly Ala Thr Asp Gln Ala Ser Ala Phe 
            180                 185                 190         


Val Arg Phe Asn Val Phe His Pro Glu Ser Ile Asp Asp Val Trp Lys 
        195                 200                 205             


Asp Lys Glu Met Phe Asp Ser Phe Ile Ser Phe Tyr Asn Asp Lys Leu 
    210                 215                 220                 


Gly Glu Glu Asp Ile Cys Phe Val Thr Gly Asn Arg Leu Pro Ser Thr 
225                 230                 235                 240 


Glu Arg His Ala Asn Lys Ile Arg His Ala Ala Asp Lys Ala Lys Leu 
                245                 250                 255     


Ile Ser Ala Asn Asp Asn Ser Gly Phe Thr Phe Arg Gly Arg Phe Lys 
            260                 265                 270         


Thr Ser Arg Glu Ala Val Gly Ile Ser Tyr Glu Val Ser Gln Lys Ala 
        275                 280                 285             


His Asn Ala Leu Lys Trp Leu Ile His Arg Gln Ser Lys Ser Ile Asp 
    290                 295                 300                 


Asp Arg Val Phe Leu Val Trp Ser Asn Asp Asn Ser Leu Val Pro Asn 
305                 310                 315                 320 


Pro Asp Glu Asp Ala Val Asp Ile Met Lys His Ala Asn Arg Glu Leu 
                325                 330                 335     


Glu Arg Asp Pro Asp Thr Gly Gln Ile Phe Ala Gly Glu Val Lys Lys 
            340                 345                 350         


Ala Ile Gly Gly Tyr Arg Ser Asp Leu Asn Tyr Gln Pro Glu Val His 
        355                 360                 365             


Ile Leu Val Leu Asp Ser Ala Thr Thr Gly Arg Met Ala Val Leu Tyr 
    370                 375                 380                 


Tyr Arg Ser Leu Asn Lys Glu Leu Tyr Leu Asn Arg Leu Glu Ala Trp 
385                 390                 395                 400 


His Asp Ser Cys Ala Trp Glu His Arg Tyr Arg Arg Asp Glu Lys Glu 
                405                 410                 415     


Phe Ile Ser Phe Tyr Gly Ala Pro Ala Thr Lys Asp Ile Ala Phe Ala 
            420                 425                 430         


Ala Tyr Gly Pro Arg Ala Ser Glu Lys Val Ile Lys Asp Leu Met Glu 
        435                 440                 445             


Arg Met Leu Pro Cys Ile Val Asp Gly Arg Arg Val Pro Lys Asp Ile 
    450                 455                 460                 


Val Arg Ser Ala Phe Gln Arg Ala Ser Asn Pro Val Ser Met Glu Arg 
465                 470                 475                 480 


Trp Glu Trp Glu Lys Thr Leu Ser Ile Thr Cys Ala Leu Ile Arg Lys 
                485                 490                 495     


Met His Ile Glu Gln Lys Glu Glu Trp Gly Val Pro Leu Asp Lys Ser 
            500                 505                 510         


Ser Thr Asp Arg Ser Tyr Leu Phe Gly Arg Leu Leu Ala Val Ala Asp 
        515                 520                 525             


Val Leu Glu Arg Gly Ala Leu Gly Lys Asp Glu Thr Arg Ala Thr Asn 
    530                 535                 540                 


Ala Ile Arg Tyr Met Asn Ser Tyr Ser Lys Asn Pro Gly Arg Thr Trp 
545                 550                 555                 560 


Lys Thr Ile Gln Glu Ser Leu Gln Pro Tyr Gln Ala Lys Leu Gly Thr 
                565                 570                 575     


Lys Ala Thr Tyr Leu Ser Lys Leu Val Asp Glu Ile Gly Asp Gln Phe 
            580                 585                 590         


Glu Pro Gly Asp Phe Asn Asn Asn Pro Leu Thr Glu Gln Tyr Leu Leu 
        595                 600                 605             


Gly Phe Tyr Ser Gln Arg Arg Glu Leu Tyr Lys Lys Lys Glu Glu Glu 
    610                 615                 620                 


Thr Asn Gln 
625         


<210>  20
<211>  283
<212>  PRT
<213>  Bacillus halodurans


<220>
<221>  PEPTIDE
<222>  (1)..(283)
<223>  CRISPR/Cas system-associated type I-C Cas7/Csd2B : WP_010896520.1

<400>  20

Met Thr Ile Leu Asp His Lys Ile Asp Phe Ala Val Ile Leu Ser Val 
1               5                   10                  15      


Thr Lys Ala Asn Pro Asn Gly Asp Pro Leu Asn Gly Asn Arg Pro Arg 
            20                  25                  30          


Gln Asn Tyr Asp Gly His Gly Glu Ile Ser Asp Val Ala Ile Lys Arg 
        35                  40                  45              


Lys Ile Arg Asn Arg Leu Leu Asp Met Glu Glu Pro Ile Phe Val Gln 
    50                  55                  60                  


Ser Asp Asp Arg Lys Ala Asp Ser Phe Lys Ser Leu Arg Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Asn Pro Glu Leu Ala Lys Met Leu Lys Ala Lys Asn Ala Ser 
                85                  90                  95      


Val Asp Glu Phe Ala Lys Ile Ala Cys Gln Glu Trp Met Asp Val Arg 
            100                 105                 110         


Ser Phe Gly Gln Val Phe Ala Phe Lys Gly Ser Asn Leu Ser Val Gly 
        115                 120                 125             


Val Arg Gly Pro Val Ser Ile His Thr Ala Thr Ser Ile Asp Pro Ile 
    130                 135                 140                 


Asp Ile Val Ser Thr Gln Ile Thr Lys Ser Val Asn Ser Val Thr Gly 
145                 150                 155                 160 


Asp Lys Arg Ser Ser Asp Thr Met Gly Met Lys His Arg Val Asp Phe 
                165                 170                 175     


Gly Val Tyr Val Phe Lys Gly Ser Ile Asn Thr Gln Leu Ala Glu Lys 
            180                 185                 190         


Thr Gly Phe Thr Asn Glu Asp Ala Glu Lys Ile Lys Arg Ala Leu Ile 
        195                 200                 205             


Thr Leu Phe Glu Asn Asp Ser Ser Ser Ala Arg Pro Asp Gly Ser Met 
    210                 215                 220                 


Glu Val His Lys Val Tyr Trp Trp Glu His Ser Ser Lys Leu Gly Gln 
225                 230                 235                 240 


Tyr Ser Ser Ala Lys Val His Arg Ser Leu Lys Ile Glu Ser Lys Thr 
                245                 250                 255     


Asp Thr Pro Lys Ser Phe Asp Asp Tyr Ala Val Glu Leu Tyr Glu Leu 
            260                 265                 270         


Asp Gly Leu Gly Val Glu Val Ile Asp Gly Gln 
        275                 280             


<210>  21
<211>  174
<212>  PRT
<213>  Bacillus halodurans


<220>
<221>  PROPEP
<222>  (1)..(174)
<223>  CRISPR/Cas system-associated exonuclease Cas4, RecB: BAB04059.1

<400>  21

Met His Lys Lys Ala Asp Gln Pro Phe Met Lys Glu Lys Arg Gly Ser 
1               5                   10                  15      


Lys Leu Thr Val Arg Ala Met Pro Ile Gln Ser Lys Asn Leu Gln Ile 
            20                  25                  30          


Ser Gly Ile Cys Asp Val Val Glu Phe Val Gln Asp Ser Glu Gly Ile 
        35                  40                  45              


Glu Leu Ser Gly Val Ser Gly Ser Tyr Lys Ala Phe Pro Val Glu Tyr 
    50                  55                  60                  


Lys Arg Gly Lys Pro Lys Lys Gly Asp Glu Asp Ile Val Gln Leu Val 
65                  70                  75                  80  


Ala Gln Ala Met Cys Leu Glu Glu Met Leu Val Cys Arg Ile Asp Lys 
                85                  90                  95      


Gly Tyr Leu Phe Tyr Asn Glu Ile Lys His Arg Val Glu Val Pro Ile 
            100                 105                 110         


Thr Asp Ala Leu Arg Asp Lys Val Val Gln Met Ala Lys Glu Met His 
        115                 120                 125             


His Tyr Tyr Glu Asn Arg His Thr Pro Lys Val Lys Thr Gly Pro Phe 
    130                 135                 140                 


Cys Asn Asn Cys Ser Leu Gln Ser Ile Cys Leu Pro Lys Leu Met Asn 
145                 150                 155                 160 


Lys Arg Ser Val Lys Arg Tyr Ile Glu Gly Arg Leu Ser Glu 
                165                 170                 


<210>  22
<211>  343
<212>  PRT
<213>  Bacillus halodurans


<220>
<221>  PEPTIDE
<222>  (1)..(343)
<223>  CRISPR-associated endonuclease Cas1, subtype I-C: WP_010896522.1

<400>  22

Met Lys Lys Leu Leu Asn Thr Leu Tyr Val Thr Gln Pro Asp Thr Tyr 
1               5                   10                  15      


Leu Ser Leu Asp Gly Asp Asn Val Val Leu Leu Lys Glu Gln Glu Lys 
            20                  25                  30          


Leu Gly Arg Leu Pro Leu His Asn Leu Glu Ala Ile Val Gly Phe Gly 
        35                  40                  45              


Tyr Thr Gly Ala Ser Pro Ala Leu Met Gly Tyr Cys Ala Glu Arg Asn 
    50                  55                  60                  


Ile Ser Ile Thr Phe Leu Thr Lys Asn Gly Arg Phe Leu Ala Arg Val 
65                  70                  75                  80  


Val Gly Glu Ser Arg Gly Asn Val Val Leu Arg Lys Thr Gln Tyr Arg 
                85                  90                  95      


Ile Ser Glu Asn Asp Gln Glu Ser Thr Lys Ile Ala Arg Asn Phe Ile 
            100                 105                 110         


Thr Gly Lys Val Tyr Asn Ser Lys Trp Met Leu Glu Arg Met Thr Arg 
        115                 120                 125             


Glu His Pro Leu Arg Val Asn Val Glu Gln Phe Lys Ala Thr Ser Gln 
    130                 135                 140                 


Leu Leu Ser Val Met Met Gln Glu Ile Arg Asn Cys Asp Ser Leu Glu 
145                 150                 155                 160 


Ser Leu Arg Gly Trp Glu Gly Gln Ala Ala Ile Asn Tyr Asn Lys Val 
                165                 170                 175     


Phe Asp Gln Met Ile Leu Gln Gln Lys Glu Glu Phe Ala Phe His Gly 
            180                 185                 190         


Arg Ser Arg Arg Pro Pro Lys Asp Asn Val Asn Ala Met Leu Ser Phe 
        195                 200                 205             


Ala Tyr Thr Leu Leu Ala Asn Asp Val Ala Ala Ala Leu Glu Thr Val 
    210                 215                 220                 


Gly Leu Asp Ala Tyr Val Gly Phe Met His Gln Asp Arg Pro Gly Arg 
225                 230                 235                 240 


Ala Ser Leu Ala Leu Asp Leu Met Glu Glu Leu Arg Gly Leu Tyr Ala 
                245                 250                 255     


Asp Arg Phe Val Leu Ser Leu Ile Asn Arg Lys Glu Met Thr Ala Asp 
            260                 265                 270         


Gly Phe Tyr Lys Lys Glu Asn Gly Ala Val Leu Met Thr Asp Glu Ala 
        275                 280                 285             


Arg Lys Thr Phe Leu Lys Ala Trp Gln Thr Lys Lys Gln Glu Lys Ile 
    290                 295                 300                 


Thr His Pro Tyr Leu Gly Glu Lys Met Ser Trp Gly Leu Val Pro Tyr 
305                 310                 315                 320 


Val Gln Ala Leu Leu Leu Ala Arg Phe Leu Arg Gly Asp Leu Asp Glu 
                325                 330                 335     


Tyr Pro Pro Phe Leu Trp Lys 
            340             


<210>  23
<211>  96
<212>  PRT
<213>  Bacillus halodurans


<220>
<221>  PEPTIDE
<222>  (1)..(96)
<223>  CRISPR/Cas system-associated protein Cas2: WP_010896523.1

<400>  23

Met Leu Val Leu Ile Thr Tyr Asp Val Gln Thr Ser Ser Met Gly Gly 
1               5                   10                  15      


Thr Lys Arg Leu Arg Lys Val Ala Lys Ala Cys Gln Asn Tyr Gly Gln 
            20                  25                  30          


Arg Val Gln Asn Ser Val Phe Glu Cys Ile Val Asp Ser Thr Gln Leu 
        35                  40                  45              


Thr Ser Leu Lys Leu Glu Leu Thr Ser Leu Ile Asp Glu Glu Lys Asp 
    50                  55                  60                  


Ser Leu Arg Ile Tyr Arg Leu Gly Asn Asn Tyr Lys Thr Lys Val Glu 
65                  70                  75                  80  


His Ile Gly Ala Lys Pro Ser Ile Asp Leu Glu Asp Pro Leu Ile Phe 
                85                  90                  95      


<210>  24
<211>  701
<212>  PRT
<213>  Cyanothece spp


<220>
<221>  PEPTIDE
<222>  (1)..(701)
<223>  type I-D CRISPR-associated helicase Cas3: WP_015783167.1

<400>  24

Met Lys Ile Asn Leu Lys Pro Leu Tyr Ser Lys Leu Asn Ala Gly Val 
1               5                   10                  15      


Gly Asn Cys Pro Leu Gly Cys Gln Glu Met Cys Arg Val Gln Gln Gln 
            20                  25                  30          


Ala Pro Gln Phe Lys Ala Pro Ser Gly Cys Asn Cys Pro Leu Tyr Gln 
        35                  40                  45              


His Gln Ala Glu Ser Tyr Pro Tyr Leu Thr Lys Gly Asp Thr Asp Ile 
    50                  55                  60                  


Ile Phe Ile Thr Ala Pro Thr Ala Gly Gly Lys Ser Leu Leu Ala Ser 
65                  70                  75                  80  


Leu Pro Ser Leu Leu Asp Pro Asn Phe Arg Met Met Gly Leu Tyr Pro 
                85                  90                  95      


Thr Ile Glu Leu Val Glu Asp Gln Thr Glu Gln Gln Asn Asn Tyr His 
            100                 105                 110         


Asn Leu Phe Gly Leu Asn Ser Glu Glu Arg Ile Asp Lys Leu Phe Gly 
        115                 120                 125             


Val Glu Leu Thr Gln Arg Ile Lys Glu Phe Asn Ser Asn Arg Phe Gln 
    130                 135                 140                 


Gln Leu Trp Leu Ala Ile Glu Thr Lys Glu Val Ile Leu Thr Asn Pro 
145                 150                 155                 160 


Asp Ile Phe His Leu Met Thr His Phe Arg Tyr Arg Asp Asn Ala Tyr 
                165                 170                 175     


Gly Thr Asp Glu Leu Pro Leu Ala Leu Ala Lys Phe Pro Asp Leu Trp 
            180                 185                 190         


Val Phe Asp Glu Phe His Ile Phe Gly Ala His Gln Glu Thr Ala Val 
        195                 200                 205             


Leu Asn Ser Met Met Leu Ile Arg Arg Thr Gln Gln Gln Lys Lys Arg 
    210                 215                 220                 


Phe Leu Phe Thr Ser Ala Thr Val Lys Thr Asp Phe Val Glu Gln Leu 
225                 230                 235                 240 


Lys Gln Thr Gly Leu Lys Ile Lys Glu Ile Ala Gly Glu Tyr Lys Ser 
                245                 250                 255     


Glu Ala Gln Gln Gly Tyr Arg Gln Ile Leu Gln Ala Val Glu Leu Ser 
            260                 265                 270         


Ile Ile Asn Leu Lys Glu Glu Asp Gly Phe Ser Trp Leu Ile Asn Asn 
        275                 280                 285             


Ala Ala Lys Ile Arg Lys Ile Leu Lys Ala Glu Asp Lys Gly Arg Gly 
    290                 295                 300                 


Leu Ile Ile Leu Asn Ser Val Val Met Val Arg Arg Ile Ser Gln Glu 
305                 310                 315                 320 


Leu Gln Ser Leu Leu Pro Glu Ile Val Val Arg Glu Ile Ser Gly Arg 
                325                 330                 335     


Ile Asp Arg Lys Glu Arg Ser Gln Thr Gln Gln Leu Leu Gln Glu Glu 
            340                 345                 350         


Glu Lys Pro Val Leu Val Val Ala Thr Ser Ala Val Asp Val Gly Val 
        355                 360                 365             


Asp Phe Arg Ile His Leu Leu Ile Thr Glu Ser Ser Asp Ser Ala Thr 
    370                 375                 380                 


Val Ile Gln Arg Leu Gly Arg Leu Gly Arg His Ser Gly Phe Ser Asn 
385                 390                 395                 400 


Tyr Gln Ala Phe Leu Leu Leu Ser Gly Arg Thr Pro Trp Val Ile Asn 
                405                 410                 415     


Arg Leu Gln Glu Lys Leu Glu Ser Lys Gln Asp Val Thr Arg Glu Glu 
            420                 425                 430         


Leu Ile Glu Ala Ile Gln Tyr Ala Phe Asp Pro Pro Lys Glu Tyr Gln 
        435                 440                 445             


Glu Tyr Arg Asn Arg Trp Gly Ala Ile Gln Val Gln Gly Met Phe Ser 
    450                 455                 460                 


Gln Met Met Gly Ser Asn Ala Lys Val Met Gln Ser Ile Lys Glu Arg 
465                 470                 475                 480 


Ile Ser Glu Asp Leu Lys Arg Ile Tyr Gly Asn Thr Leu Asp Asn Lys 
                485                 490                 495     


Ala Trp Tyr Ala Met Gly His Asn Cys Leu Gly Lys Ala Ile Gln Ser 
            500                 505                 510         


Glu Leu Leu Arg Phe Arg Gly Gly Ser Thr Leu Gln Ala Ala Val Trp 
        515                 520                 525             


Asp Glu Gln Arg Phe Tyr Thr Tyr Asp Leu Leu Arg Leu Leu Pro Tyr 
    530                 535                 540                 


Ala Thr Val Asp Ile Leu Asp Arg Glu Thr Phe Leu Lys Ala Ala Thr 
545                 550                 555                 560 


Lys Ala Gly His Ile Glu Glu Ala Phe Pro Ser Gln Tyr Leu Gln Val 
                565                 570                 575     


Tyr Leu Arg Ile Glu Gln Trp Leu Asp Lys Arg Leu Asn Leu Asn Leu 
            580                 585                 590         


Phe Cys Asn Arg Glu Ser Asp Glu Leu Leu Val Gly Lys Leu Phe Leu 
        595                 600                 605             


Ile Thr Arg Leu Lys Leu Asp Gly His Pro Gln Ser Asp Val Ile Ser 
    610                 615                 620                 


Cys Leu Ser Arg Cys Asn Leu Leu Thr Phe Leu Val Pro Val Asp Arg 
625                 630                 635                 640 


Ser Arg Thr Gln Ser His Trp Glu Val Ser Tyr Cys Leu His Leu Asn 
                645                 650                 655     


Pro Leu Phe Gly Leu Tyr Arg Leu Lys Asp Ala Ser Glu Gln Ala Tyr 
            660                 665                 670         


Ala Cys Ala Phe Asn Gln Asp Ala Leu Leu Leu Glu Ala Leu Asn Trp 
        675                 680                 685             


Lys Leu Thr Lys Phe Tyr Arg Glu Arg Ser Leu Ile Phe 
    690                 695                 700     


<210>  25
<211>  97
<212>  PRT
<213>  Cyanothece spp


<220>
<221>  PROPEP
<222>  (1)..(97)
<223>  CRISPR/Cas system-associated endonuclease Cas2: WP_015783160.1

<400>  25

Met Asn Thr Leu Phe Tyr Leu Ile Ile Tyr Asp Leu Pro Ala Thr Lys 
1               5                   10                  15      


Ala Gly Asn Lys Arg Arg Lys Arg Leu Tyr Glu Met Leu Cys Gly Tyr 
            20                  25                  30          


Gly Asn Trp Thr Gln Phe Ser Val Phe Glu Cys Phe Leu Thr Ala Val 
        35                  40                  45              


Gln Phe Ala Asn Leu Gln Ser Lys Leu Glu Asn Leu Ile Gln Pro Asn 
    50                  55                  60                  


Glu Asp Ser Val Arg Ile Tyr Ile Leu Asp Ala Gly Ser Val Arg Lys 
65                  70                  75                  80  


Thr Leu Thr Tyr Gly Ser Glu Lys Pro Arg Gln Val Asp Thr Leu Ile 
                85                  90                  95      


Leu 
    


<210>  26
<211>  325
<212>  PRT
<213>  Cyanothece spp


<220>
<221>  PEPTIDE
<222>  (1)..(325)
<223>  type I-D CRISPR-associated endonuclease Cas1: WP_015783161.1

<400>  26

Met Ser Ile Leu Tyr Leu Thr Gln Pro Asp Ala Val Leu Ser Lys Lys 
1               5                   10                  15      


Gln Glu Ala Phe His Val Ala Leu Lys Gln Glu Asp Gly Ser Trp Lys 
            20                  25                  30          


Lys Gln Leu Ile Pro Ala Gln Thr Val Glu Gln Ile Val Leu Ile Gly 
        35                  40                  45              


Tyr Pro Ser Ile Thr Gly Glu Ala Leu Cys Tyr Ala Leu Glu Leu Gly 
    50                  55                  60                  


Ile Pro Val His Tyr Leu Ser Cys Phe Gly Lys Tyr Leu Gly Ser Ala 
65                  70                  75                  80  


Leu Pro Gly Tyr Ser Arg Asn Gly Gln Leu Arg Leu Ala Gln Tyr His 
                85                  90                  95      


Val His Asp Asn Glu Glu Gln Arg Leu Ala Leu Val Lys Thr Val Val 
            100                 105                 110         


Thr Gly Lys Ile His Asn Gln Tyr His Val Leu Tyr Arg Tyr Gln Gln 
        115                 120                 125             


Lys Asp Asn Pro Leu Lys Glu His Lys Gln Leu Val Lys Ser Lys Thr 
    130                 135                 140                 


Thr Leu Glu Gln Val Arg Gly Val Glu Gly Leu Ala Ala Lys Asp Tyr 
145                 150                 155                 160 


Phe Asn Gly Phe Lys Leu Ile Leu Asp Ser Gln Trp Asn Phe Asn Gly 
                165                 170                 175     


Arg Asn Arg Arg Pro Pro Thr Asp Pro Val Asn Ala Leu Leu Ser Phe 
            180                 185                 190         


Ala Tyr Gly Leu Leu Arg Val Gln Val Thr Ala Ala Val His Ile Ala 
        195                 200                 205             


Gly Leu Asp Pro Tyr Ile Gly Tyr Leu His Glu Thr Thr Arg Gly Gln 
    210                 215                 220                 


Pro Ala Met Val Leu Asp Leu Met Glu Glu Phe Arg Pro Leu Ile Ala 
225                 230                 235                 240 


Asp Ser Leu Val Leu Ser Val Ile Ser His Lys Glu Ile Lys Pro Thr 
                245                 250                 255     


Asp Phe Asn Glu Ser Leu Gly Ala Tyr Leu Leu Ser Asp Ser Gly Arg 
            260                 265                 270         


Lys Thr Phe Leu Gln Ala Phe Glu Arg Lys Leu Asn Thr Glu Phe Lys 
        275                 280                 285             


His Pro Val Phe Gly Tyr Gln Cys Ser Tyr Arg Arg Ser Ile Glu Leu 
    290                 295                 300                 


Gln Ala Arg Leu Phe Ser Arg Tyr Leu Gln Glu Asn Ile Pro Tyr Lys 
305                 310                 315                 320 


Ser Leu Ser Leu Arg 
                325 


<210>  27
<211>  196
<212>  PRT
<213>  Cyanothece spp


<220>
<221>  PEPTIDE
<222>  (1)..(196)
<223>  CRISPR-associated protein Cas4: WP_015783162.1

<400>  27

Met Ile Asp Asn Tyr Leu Pro Leu Ala Tyr Leu Asn Ala Phe Glu Tyr 
1               5                   10                  15      


Cys Thr Arg Arg Phe Tyr Trp Glu Tyr Val Leu Gly Glu Met Ala Asn 
            20                  25                  30          


Asn Glu His Ile Ile Ile Gly Arg His Leu His Arg Asn Ile Asn Gln 
        35                  40                  45              


Glu Gly Ile Ile Lys Glu Glu Asp Thr Ile Ile His Arg Gln Gln Trp 
    50                  55                  60                  


Val Trp Ser Asp Arg Leu Gln Ile Lys Gly Ile Ile Asp Ala Val Glu 
65                  70                  75                  80  


Glu Lys Glu Ser Ser Leu Val Pro Val Glu Tyr Lys Lys Gly Arg Met 
                85                  90                  95      


Ser Gln His Leu Asn Asp His Phe Gln Leu Cys Ala Ala Ala Leu Cys 
            100                 105                 110         


Leu Glu Glu Lys Thr Gly Lys Ile Ile Thr Tyr Gly Glu Ile Phe Tyr 
        115                 120                 125             


His Ala Asn Arg Arg Arg Gln Arg Val Asp Phe Ser Asp Arg Leu Arg 
    130                 135                 140                 


Cys Ser Thr Glu Gln Ala Ile His His Ala His Glu Leu Val Asn Gln 
145                 150                 155                 160 


Lys Met Pro Ser Pro Ile Asn Asn Ser Lys Lys Cys Arg Asp Cys Ser 
                165                 170                 175     


Leu Lys Thr Met Cys Leu Pro Lys Glu Val Lys Gln Leu Arg Asn Ser 
            180                 185                 190         


Leu Ile Ser Asp 
        195     


<210>  28
<211>  269
<212>  PRT
<213>  Cyanothece spp


<220>
<221>  PEPTIDE
<222>  (1)..(269)
<223>  CRISPR system precrRNA processing endoribonuclease RAMP protein 
       Cas6: WP_015783163.1

<400>  28

Met Val Gln Asp Ile Leu Pro Gln Leu His Lys Tyr Gln Leu Gln Ser 
1               5                   10                  15      


Leu Val Ile Glu Leu Gly Val Ala Lys Gln Gly Lys Leu Pro Ala Thr 
            20                  25                  30          


Leu Ser Arg Ala Ile His Ala Cys Val Leu Asn Trp Leu Ser Leu Ala 
        35                  40                  45              


Asp Ser Gln Leu Ala Asn Gln Ile His Asp Ser Gln Ile Ser Pro Leu 
    50                  55                  60                  


Cys Leu Ser Gly Leu Ile Gly Asn Arg Arg Gln Pro Tyr Ser Leu Leu 
65                  70                  75                  80  


Gly Asp Tyr Phe Leu Leu Arg Ile Gly Val Leu Gln Pro Ser Leu Ile 
                85                  90                  95      


Lys Pro Leu Leu Lys Gly Ile Glu Ala Gln Glu Thr Gln Thr Leu Glu 
            100                 105                 110         


Leu Gly Lys Phe Pro Phe Ile Ile Arg Gln Val Tyr Ser Met Pro Gln 
        115                 120                 125             


Ser His Lys Leu Ser Gln Leu Thr Asp Tyr Tyr Ser Leu Ala Leu Tyr 
    130                 135                 140                 


Ser Pro Thr Met Thr Glu Ile Gln Leu Lys Phe Leu Ser Pro Thr Ser 
145                 150                 155                 160 


Phe Lys Gln Ile Gln Gly Val Gln Pro Phe Pro Leu Pro Glu Leu Val 
                165                 170                 175     


Phe Asn Ser Leu Leu Arg Lys Trp Asn His Phe Ala Pro Gln Glu Leu 
            180                 185                 190         


Lys Phe Pro Glu Ile Gln Trp Gln Ser Phe Val Ser Ala Phe Glu Leu 
        195                 200                 205             


Lys Thr His Ala Leu Lys Met Glu Gly Gly Ala Gln Ile Gly Ser Gln 
    210                 215                 220                 


Gly Trp Ala Lys Tyr Cys Phe Lys Asp Thr Glu Gln Ala Arg Ile Ala 
225                 230                 235                 240 


Ser Ile Leu Ser His Phe Ala Phe Tyr Ala Gly Val Gly Arg Lys Thr 
                245                 250                 255     


Thr Met Gly Met Gly Gln Thr Gln Leu Leu Val Asn Thr 
            260                 265                 


<210>  29
<211>  258
<212>  PRT
<213>  Cyanothece spp


<220>
<221>  PEPTIDE
<222>  (1)..(258)
<223>  type I-D CRISPR-associated protein Cas5/Csc1: WP_015783164.1

<400>  29

Met Asn Ile Tyr Tyr Cys Gln Leu Thr Leu His Asp Asn Ile Phe Phe 
1               5                   10                  15      


Ala Thr Arg Glu Met Gly Leu Leu Tyr Glu Thr Glu Lys Tyr Leu His 
            20                  25                  30          


Asn Trp Ala Leu Ser Tyr Ala Phe Phe Lys Gly Thr Tyr Ile Pro His 
        35                  40                  45              


Pro Tyr Arg Leu Gln Gly Lys Ser Ala Gln Lys Pro Asp Tyr Leu Asp 
    50                  55                  60                  


Ser Thr Gly Glu Gln Ser Leu Ala His Leu Asn Arg Leu Lys Ile Tyr 
65                  70                  75                  80  


Val Phe Pro Ala Lys Pro Leu Arg Trp Ser Tyr Gln Ile Asn Thr Phe 
                85                  90                  95      


Lys Ala Ala Gln Thr Thr Tyr Tyr Gly Lys Ser Gln Gln Phe Gly Asp 
            100                 105                 110         


Lys Gly Ala Asn Arg Asn Tyr Pro Ile Asn Tyr Gly Arg Ala Lys Glu 
        115                 120                 125             


Leu Ala Val Gly Ser Glu Tyr His Thr Phe Leu Ile Ser Ser Gln Glu 
    130                 135                 140                 


Leu Asn Ile Pro His Trp Ile Arg Val Gly Lys Trp Ser Ala Lys Val 
145                 150                 155                 160 


Glu Val Thr Ser Tyr Leu Ile Pro Gln Lys Ala Ile Ser Gln His Ser 
                165                 170                 175     


Gly Ile Tyr Leu Cys Asp His Pro Leu Asn Pro Ile Asp Leu Pro Phe 
            180                 185                 190         


Asp Gln Glu Leu Leu Leu Tyr Asn Arg Ile Val Met Pro Pro Val Ser 
        195                 200                 205             


Leu Val Ser Gln Ala Gln Leu Gln Gly Asn Tyr Cys Lys Ile Asn Lys 
    210                 215                 220                 


Asn Asn Trp Asn Asp Cys Pro Ser Asn Leu Thr Asp Leu Pro Gln Gln 
225                 230                 235                 240 


Ile Cys Leu Pro Leu Gly Val Asn Tyr Gly Ala Gly Tyr Ile Ala Ser 
                245                 250                 255     


Ala Ser 
        


<210>  30
<211>  356
<212>  PRT
<213>  Cyanothece spp


<220>
<221>  PEPTIDE
<222>  (1)..(356)
<223>  type I-D CRISPR-associated protein Cas7/Csc2:WP_015783165.1

<400>  30

Met Ser Ile Leu Glu Thr Leu Lys Pro Gln Phe Gln Ser Ala Phe Pro 
1               5                   10                  15      


Arg Leu Ala Ser Ala Asn Tyr Val His Phe Ile Met Leu Arg His Ser 
            20                  25                  30          


Gln Ser Phe Pro Val Phe Gln Thr Asp Gly Val Leu Asn Thr Val Arg 
        35                  40                  45              


Thr Gln Ala Gly Leu Met Ala Lys Asp Ser Leu Ser Arg Leu Val Met 
    50                  55                  60                  


Phe Lys Arg Lys Gln Thr Thr Pro Glu Arg Leu Thr Gly Arg Glu Leu 
65                  70                  75                  80  


Leu Arg Ser Leu Asn Ile Thr Thr Ala Asp Lys Asn Asp Lys Glu Lys 
                85                  90                  95      


Gly Cys Glu Tyr Asn Gly Glu Gly Ser Cys Lys Lys Cys Pro Asp Cys 
            100                 105                 110         


Ile Ile Tyr Gly Phe Ala Ile Gly Asp Ser Gly Ser Glu Arg Ser Lys 
        115                 120                 125             


Val Tyr Ser Asp Ser Thr Phe Ser Leu Ser Ala Tyr Glu Gln Ser His 
    130                 135                 140                 


Arg Thr Phe Thr Phe Asn Ala Pro Phe Glu Gly Gly Thr Met Ser Glu 
145                 150                 155                 160 


Gln Gly Val Met Arg Ser Ala Ile Asn Glu Leu Asp His Ile Leu Pro 
                165                 170                 175     


Glu Ile Thr Phe Pro Asn Ile Glu Thr Leu Arg Asp Ser Thr Tyr Glu 
            180                 185                 190         


Gly Phe Ile Tyr Val Leu Gly Asn Ile Leu Arg Thr Lys Arg Tyr Gly 
        195                 200                 205             


Ala Gln Glu Ser Arg Thr Gly Thr Met Lys Asn His Leu Val Gly Ile 
    210                 215                 220                 


Ala Phe Cys Asp Gly Glu Ile Phe Ser Asn Leu Arg Phe Thr Gln Ala 
225                 230                 235                 240 


Leu Tyr Asp Gly Leu Glu Gly Asp Val Asn Lys Pro Ile Asp Glu Ile 
                245                 250                 255     


Cys Tyr Gln Ala Ser Gln Ile Val Gln Thr Leu Leu Ser Asp Glu Pro 
            260                 265                 270         


Val Arg Lys Ile Lys Thr Ile Phe Gly Glu Glu Leu Asn His Leu Ile 
        275                 280                 285             


Asn Glu Val Ser Gly Ile Tyr Gln Asn Asp Ala Leu Leu Thr Glu Thr 
    290                 295                 300                 


Leu Asn Met Leu Tyr Gln Gln Thr Lys Thr Tyr Ser Glu Asn His Gly 
305                 310                 315                 320 


Ser Leu Ala Lys Ser Lys Pro Pro Lys Ala Glu Gly Asn Lys Ser Lys 
                325                 330                 335     


Gly Arg Thr Lys Lys Lys Gly Asp Asp Glu Gln Thr Ser Leu Asp Leu 
            340                 345                 350         


Asn Ile Glu Glu 
        355     


<210>  31
<211>  974
<212>  PRT
<213>  Cyanothece spp


<220>
<221>  PEPTIDE
<222>  (1)..(974)
<223>  type I-D CRISPR-associated protein Cas10d/Csc3: WP_015783166.1

<400>  31

Met Thr Leu Leu Gln Ile Leu Leu Leu Glu Thr Ile Ser Gln Asp Thr 
1               5                   10                  15      


Asp Pro Ile Leu Ile Ser Tyr Leu Glu Thr Val Leu Pro Ala Met Glu 
            20                  25                  30          


Pro Glu Phe Ala Leu Ile Pro Ala Leu Gly Gly Ser Gln Gln Ile His 
        35                  40                  45              


Tyr Gln Asn Leu Ile Ala Ile Gly Asn Arg Tyr Ala Gln Glu Asn Ala 
    50                  55                  60                  


Lys Arg Phe Ser Asp Lys Ala Asp Gln Asn Leu Leu Val His Val Leu 
65                  70                  75                  80  


Asn Ala Leu Leu Thr Ala Trp Asn Leu Val Asp His Leu Thr Lys Pro 
                85                  90                  95      


Leu Ser Asp Ile Glu Lys Tyr Leu Leu Cys Leu Gly Leu Thr Leu His 
            100                 105                 110         


Asp Tyr Asn Lys Tyr Cys Leu Gly His Gly Glu Glu Ser Pro Lys Val 
        115                 120                 125             


Ser Asn Ile Asn Glu Ile Ile Asn Ile Cys Gln Glu Leu Gly Lys Lys 
    130                 135                 140                 


Leu Asn Phe Gln Ala Phe Trp Ser Asp Trp Glu Gln Tyr Leu Pro Glu 
145                 150                 155                 160 


Ile Val Tyr Leu Ala Gln Asn Thr Gln Phe Lys Ala Gly Thr Asn Ala 
                165                 170                 175     


Ile Pro Ala Asn Tyr Pro Leu Phe Thr Leu Ala Asp Ser Arg Arg Leu 
            180                 185                 190         


Asp Leu Pro Leu Arg Arg Leu Leu Ala Phe Gly Asp Ile Ala Val His 
        195                 200                 205             


Leu Gln Asp Pro Ala Asp Ile Ile Ser Lys Thr Gly Gly Asp Arg Leu 
    210                 215                 220                 


Arg Glu His Leu Arg Phe Leu Gly Ile Lys Lys Ala Leu Val Tyr His 
225                 230                 235                 240 


Arg Leu Arg Asp Thr Leu Gly Ile Leu Ser Asn Gly Ile His Asn Ala 
                245                 250                 255     


Thr Leu Arg Phe Ala Lys Asp Leu Asn Trp Gln Pro Leu Leu Phe Phe 
            260                 265                 270         


Ala Gln Gly Val Ile Tyr Leu Ala Pro Ile Asp Tyr Thr Ser Pro Glu 
        275                 280                 285             


Lys Met Glu Leu Gln Gly Phe Ile Trp Gln Glu Ile Ser Gln Leu Leu 
    290                 295                 300                 


Ala Ser Ser Met Leu Lys Gly Glu Ile Gly Phe Lys Arg Asp Gly Lys 
305                 310                 315                 320 


Gly Leu Lys Val Ala Pro Gln Thr Leu Glu Leu Phe Thr Pro Val Gln 
                325                 330                 335     


Leu Ile Arg Asn Leu Ala Asp Val Ile Asn Val Lys Val Ala Asn Ala 
            340                 345                 350         


Lys Val Pro Ala Thr Pro Lys Arg Leu Glu Lys Leu Glu Leu Thr Asp 
        355                 360                 365             


Ile Glu Arg Gln Leu Leu Glu Lys Gly Ala Asp Leu Arg Ala Asp Arg 
    370                 375                 380                 


Ile Ala Glu Leu Ile Ile Leu Ala Gln Arg Glu Phe Leu Ala Asp Ser 
385                 390                 395                 400 


Pro Glu Phe Ile Asp Trp Thr Leu Gln Phe Trp Gly Leu Glu Lys Gln 
                405                 410                 415     


Ile Thr Ala Glu Gln Thr Gln Glu Gln Ser Gly Gly Val Asn Tyr Gly 
            420                 425                 430         


Trp Tyr Arg Val Ala Ala Asn Tyr Ile Ala Asn His Ser Thr Leu Ser 
        435                 440                 445             


Leu Glu Asp Val Ser Gly Lys Leu Val Asp Phe Cys Gln Gln Leu Ala 
    450                 455                 460                 


Asp Trp Ala Thr Ser Asn Gln Leu Leu Ser Ser His Ser Ser Ser Thr 
465                 470                 475                 480 


Phe Glu Val Phe Asn Ser Tyr Leu Glu Gln Tyr Leu Glu Ile Gln Gly 
                485                 490                 495     


Trp Gln Ser Ser Thr Pro Asn Phe Ser Gln Glu Leu Ser Thr Tyr Ile 
            500                 505                 510         


Met Ala Lys Thr Gln Ser Ser Lys Gln Pro Ile Cys Ser Leu Ser Ser 
        515                 520                 525             


Gly Glu Phe Ile Ser Glu Asp Gln Met Asp Ser Val Val Leu Phe Lys 
    530                 535                 540                 


Pro Gln Gln Tyr Ser Asn Lys Asn Pro Leu Gly Gly Gly Lys Ile Lys 
545                 550                 555                 560 


Arg Gly Ile Ser Lys Ile Trp Ala Leu Glu Met Leu Leu Arg Gln Ala 
                565                 570                 575     


Leu Trp Thr Val Pro Ser Gly Lys Phe Glu Asp Gln Gln Pro Val Phe 
            580                 585                 590         


Leu Tyr Ile Phe Pro Ala Tyr Val Tyr Ser Pro Gln Ile Ala Ala Ala 
        595                 600                 605             


Ile Arg Ser Leu Val Asn Asp Met Lys Arg Ile Asn Leu Trp Asp Val 
    610                 615                 620                 


Arg Lys His Trp Leu His Glu Asp Met Asn Leu Asp Ser Leu Arg Ser 
625                 630                 635                 640 


Leu Gln Trp Arg Lys Glu Glu Ala Glu Val Gly Arg Phe Lys Asp Lys 
                645                 650                 655     


Tyr Ser Arg Ala Asp Ile Pro Phe Met Gly Thr Val Tyr Thr Thr Thr 
            660                 665                 670         


Arg Gly Lys Thr Leu Thr Glu Ala Trp Ile Asp Pro Ala Phe Leu Thr 
        675                 680                 685             


Leu Ala Leu Pro Ile Leu Leu Gly Val Lys Val Ile Ala Thr Ser Ser 
    690                 695                 700                 


Ser Val Pro Leu Tyr Asn Ser Asp Asn Asp Phe Leu Asp Ser Val Ile 
705                 710                 715                 720 


Leu Asp Ala Pro Ala Gly Phe Trp Gln Leu Leu Lys Leu Ser Thr Ser 
                725                 730                 735     


Leu Arg Ile Gln Glu Leu Ser Val Ala Leu Lys Arg Leu Leu Thr Ile 
            740                 745                 750         


Tyr Thr Ile His Leu Asp Asn Arg Ser Asn Pro Pro Asp Ala Arg Trp 
        755                 760                 765             


Gln Ala Leu Asn Ser Thr Val Arg Glu Val Ile Thr Asp Val Leu Asn 
    770                 775                 780                 


Val Phe Ser Ile Ala Asp Glu Lys Leu Arg Glu Asp Gln Arg Glu Ala 
785                 790                 795                 800 


Ser Pro Gln Glu Val Gln Arg Tyr Trp Lys Phe Ala Glu Ile Phe Ala 
                805                 810                 815     


Gln Gly Asp Thr Ile Met Thr Glu Lys Leu Lys Leu Thr Lys Glu Leu 
            820                 825                 830         


Val Arg Gln Tyr Arg Thr Phe Tyr Gln Val Lys Trp Ser Glu Ser Ser 
        835                 840                 845             


His Thr Ile Leu Leu Pro Leu Thr Lys Ala Leu Glu Glu Ile Leu Ser 
    850                 855                 860                 


Thr Pro Glu His Trp Asp Asp Glu Glu Leu Ile Leu Gln Gly Ala Gly 
865                 870                 875                 880 


Ile Leu Asn Asp Ala Leu Asp Arg Gln Glu Val Tyr Lys Arg Pro Leu 
                885                 890                 895     


Leu Gln Asp Lys Ser Ile Pro Tyr Glu Ile Arg Lys Gln Gln Glu Leu 
            900                 905                 910         


Gln Ala Ile His Gln Phe Met Thr Thr Cys Val Lys Glu Leu Phe Gly 
        915                 920                 925             


Gln Met Cys Lys Gly Asp Arg Ala Leu Leu Gln Glu Tyr Arg Asn Arg 
    930                 935                 940                 


Ile Lys Ser Gly Ala Glu Ser Ala Tyr Lys Leu Leu Ala Phe Glu Glu 
945                 950                 955                 960 


Lys Ser Asn Ser Ser Gln Gln Gln Lys Ser Ser Glu Asp Gln 
                965                 970                 


<210>  32
<211>  888
<212>  PRT
<213>  Escherichia coli


<220>
<221>  PEPTIDE
<222>  (1)..(888)
<223>  Cascade complex anti-viral R-loop helicase-annealase 
       Cas3:NP_417241.1

<400>  32

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  33
<211>  94
<212>  PRT
<213>  Escherichia coli


<220>
<221>  PEPTIDE
<222>  (1)..(94)
<223>  CRISPR adaptation ssRNA endonuclease: NP_417234.2

<400>  33

Met Ser Met Leu Val Val Val Thr Glu Asn Val Pro Pro Arg Leu Arg 
1               5                   10                  15      


Gly Arg Leu Ala Ile Trp Leu Leu Glu Val Arg Ala Gly Val Tyr Val 
            20                  25                  30          


Gly Asp Val Ser Ala Lys Ile Arg Glu Met Ile Trp Glu Gln Ile Ala 
        35                  40                  45              


Gly Leu Ala Glu Glu Gly Asn Val Val Met Ala Trp Ala Thr Asn Thr 
    50                  55                  60                  


Glu Thr Gly Phe Glu Phe Gln Thr Phe Gly Leu Asn Arg Arg Thr Pro 
65                  70                  75                  80  


Val Asp Leu Asp Gly Leu Arg Leu Val Ser Phe Leu Pro Val 
                85                  90                  


<210>  34
<211>  328
<212>  PRT
<213>  Yersinia pseudotuberculosis


<220>
<221>  PEPTIDE
<222>  (1)..(328)
<223>  type I-F CRISPR-associated endonuclease Cas1: WP_072080408.1

<400>  34

Met Ala Met Glu Asn Ala Ile His Ser Ser Asp Leu Lys Thr Ile Leu 
1               5                   10                  15      


His Ser Lys Arg Ser Asn Ile Tyr Tyr Leu Glu Tyr Cys Arg Val Leu 
            20                  25                  30          


Val Asn Gly Gly Arg Val Glu Tyr Val Thr Asp Glu Gly Lys Gln Ser 
        35                  40                  45              


Leu Tyr Trp Asn Ile Pro Ile Ala Asn Thr Thr Val Ile Met Leu Gly 
    50                  55                  60                  


Thr Gly Thr Ser Val Thr Gln Ala Ala Met Arg Glu Phe Ala Arg Ala 
65                  70                  75                  80  


Gly Val Leu Val Gly Phe Cys Gly Gly Gly Gly Thr Pro Leu Phe Ala 
                85                  90                  95      


Ala Asn Asp Val Glu Val Asn Val Ser Trp Leu Thr Ala Gln Ser Glu 
            100                 105                 110         


Tyr Arg Pro Thr Glu Tyr Leu His Asp Trp Val Ser Phe Trp Phe Asp 
        115                 120                 125             


Asp Glu Lys Arg Leu Ala Ala Ala Val Ala Phe Gln Arg Ile Arg Ile 
    130                 135                 140                 


Ala Gln Ile Gln Gln His Trp Leu Ser Ser His Ile Gln Arg Glu Ser 
145                 150                 155                 160 


Leu Phe Pro Val Asn His Asp Gln Leu Leu Phe Ile Leu Ser Arg Phe 
                165                 170                 175     


Glu Gln Asn Leu Ala Asn Cys Leu Thr Ser Asn Asp Leu Met Val Gln 
            180                 185                 190         


Glu Ala Val Leu Thr Lys Ala Leu Tyr Lys Leu Ala Ala Asn Thr Val 
        195                 200                 205             


Asn Tyr Gly Asp Phe Thr Arg Ala Lys Arg Gly Gly Gly Ile Asp Leu 
    210                 215                 220                 


Ala Asn Arg Phe Leu Asp His Gly Asn Tyr Leu Ala Tyr Gly Leu Ala 
225                 230                 235                 240 


Ala Thr Ala Thr Trp Val Ile Gly Leu Pro His Gly Leu Ser Val Leu 
                245                 250                 255     


His Gly Lys Thr Arg Arg Gly Gly Leu Val Phe Asp Val Ala Asp Leu 
            260                 265                 270         


Ile Lys Asp Ala Leu Val Leu Pro Gln Ala Phe Ile Ala Ala Met Gln 
        275                 280                 285             


Gly Glu Glu Glu Gln Glu Phe Arg Gln Arg Cys Ile Ser Gly Phe Gln 
    290                 295                 300                 


Arg Thr Glu Ala Leu Asp Val Met Ile Asp Gly Ile Lys Glu Thr Ala 
305                 310                 315                 320 


Ala Leu Cys Ser Gln Val Pro Arg 
                325             


<210>  35
<211>  1095
<212>  PRT
<213>  Yersinia pseudotuberculosis


<220>
<221>  PEPTIDE
<222>  (1)..(1095)
<223>  type I-F CRISPR-associated helicase Cas3: WP_012303962.1

<400>  35

Met Asn Ile Leu Leu Ile Ser Gln Cys His Lys Arg Ala Leu Asp Glu 
1               5                   10                  15      


Thr Arg Arg Ile Leu Asp Gln Phe Ala Glu Arg Lys Gly Asp Arg Thr 
            20                  25                  30          


Trp Gln Thr Ala Ile Thr Gln Glu Gly Leu Asn Thr Leu Arg Lys Leu 
        35                  40                  45              


Leu Arg Arg Thr Ala Arg Arg Asn Ser Ala Val Ala Cys His Trp Ile 
    50                  55                  60                  


Lys Ser Asn Asn Gln Ser Glu Leu Leu Trp Ile Val Gly Asn Leu Arg 
65                  70                  75                  80  


Arg Phe Asn Ala Glu Gly Thr Val Pro Thr Asn Thr Thr Gln Arg Asp 
                85                  90                  95      


Ile Leu Arg Ser Gln Asp Glu Asn Asn Trp His Ser Val Glu Thr Ile 
            100                 105                 110         


Ala Leu Leu Ala Gly Ile Ala Gly Leu Phe His Asp Phe Gly Lys Ala 
        115                 120                 125             


Asn Val Leu Phe Gln Gln Gly Leu Gln Gly Gln Gly Lys Thr Tyr Gln 
    130                 135                 140                 


Pro Tyr Arg His Glu Trp Val Ser Leu Arg Leu Phe Gln Ala Phe Val 
145                 150                 155                 160 


Glu Gln Lys Asn Asp Ile Gln Trp Leu Thr Ala Leu Ser Gln Ile Asn 
                165                 170                 175     


Pro Ala Asp Glu Thr Ala Leu Met Ser Asn Leu Val Lys Asp Gly Leu 
            180                 185                 190         


Asp Asp Tyr Thr Asn Pro Leu Ala Ala Leu Pro Pro Leu Ala Lys Thr 
        195                 200                 205             


Ile Ala Trp Leu Ile Leu Ser His His Arg Leu Pro Val Tyr Pro Ser 
    210                 215                 220                 


Lys Asp Tyr His Arg Pro Pro Lys Val Glu Glu Ile Asp Asp Trp Leu 
225                 230                 235                 240 


His Gln Gln Leu Met Pro Val Trp Asn Ser Thr Asn Met Asp Ser Gly 
                245                 250                 255     


Asp Trp Arg Glu Lys Asp Lys Leu Asp Val Trp Arg Phe Pro His Gly 
            260                 265                 270         


Thr Pro Leu Gln Ser Ala Glu Trp Cys Lys Lys Ala Gln Lys Phe Ala 
        275                 280                 285             


Lys Arg Ala Leu Arg Gln Pro Ser Leu Val Asn Asp Gly His Leu Asn 
    290                 295                 300                 


Gln Arg Phe Thr Ser His Met Ala Arg Leu Val Leu Met Leu Ala Asp 
305                 310                 315                 320 


His His Tyr Ser Ser Leu Pro Ala Thr Pro Gly Trp Gln Asp Lys Asn 
                325                 330                 335     


Tyr Gln Val Phe Ala Asn Thr His Asn Lys Met Arg Asp Ala Asn Ala 
            340                 345                 350         


His Ser Lys Thr Ile Glu Met Lys Gln Arg Leu Asp Glu His Asn Ile 
        355                 360                 365             


Gly Val Gly Gln Asn Ala Leu Leu Leu Gly Arg Ser Leu Pro His Ile 
    370                 375                 380                 


Arg Lys Thr Leu Pro Ala Ile Thr Arg His Lys Gly Phe Lys Gln Arg 
385                 390                 395                 400 


Ser Val Gln Glu Lys Tyr Arg Trp Gln Asp Lys Ala Phe Asp Leu Ala 
                405                 410                 415     


Val Thr Leu Arg Glu Arg Ser Leu Gln Gln Gly Phe Phe Gly Val Asn 
            420                 425                 430         


Met Ala Ser Thr Gly Cys Gly Lys Thr Phe Ala Asn Ala Arg Ile Met 
        435                 440                 445             


Tyr Gly Leu Ser Asp Glu Lys Gln Gly Cys Arg Phe Ser Val Ala Leu 
    450                 455                 460                 


Gly Leu Arg Thr Leu Thr Leu Gln Thr Gly Thr Ala Leu Gln Gln Lys 
465                 470                 475                 480 


Leu Thr Leu Gln Lys Asp Asp Leu Ala Val Leu Ile Gly Ser Gln Ser 
                485                 490                 495     


Val Leu Gln Leu Tyr Gln Leu Asn Asn Asp Lys Leu Glu Pro Arg Gly 
            500                 505                 510         


Thr Gly Ser Gln Ser Ala Asp Lys Phe Phe Ser Glu His Gln Tyr Val 
        515                 520                 525             


Ser Tyr Asp Gly Ser Leu Asp Asp Gly Arg Leu Ser Thr Trp Leu Ser 
    530                 535                 540                 


Asn Asn Asp Arg Leu Lys Arg Leu Leu Cys Ala Pro Val Leu Val Cys 
545                 550                 555                 560 


Thr Ile Asp His Leu Ile Pro Ala Thr Glu Ser Leu Arg Gly Gly Lys 
                565                 570                 575     


Gln Ile Ala Pro Met Leu Arg Leu Leu Thr Ser Asp Leu Val Leu Asp 
            580                 585                 590         


Glu Pro Asp Asp Phe Asp Arg Asn Asp Leu Pro Ala Leu Cys Arg Leu 
        595                 600                 605             


Val Asn Trp Ala Gly Met Leu Gly Ser Arg Val Leu Leu Ser Ser Ala 
    610                 615                 620                 


Thr Leu Pro Pro Ala Leu Val Gln Ala Leu Phe Asn Ala Tyr Arg Ala 
625                 630                 635                 640 


Gly Arg Ala Asp Tyr Gln Gln Ala Ser Gly Gln Pro Asp Thr Pro Val 
                645                 650                 655     


Asn Ile Cys Cys Ala Trp Phe Asp Glu His Gly Val Ala Gln Gln Asp 
            660                 665                 670         


Ile Gln Gln Ser Lys Asp Phe Ile Gln His His Gly Asp Phe Ile Thr 
        675                 680                 685             


Arg Arg Val Gly Lys Leu Ser Thr Ala Glu Val Leu Arg Arg Ala Glu 
    690                 695                 700                 


Leu Ile Pro Val Ser Ser Ala Ser Val Lys Asn Gly Ser Val Leu Asp 
705                 710                 715                 720 


Ala Met Ala Ala Val Met Arg Asp Ser Met Leu Arg Leu His Gln Ala 
                725                 730                 735     


His His Gln Thr His Pro Ser Glu Lys Thr Val Ser Val Gly Val Val 
            740                 745                 750         


Arg Met Ala Asn Ile Asp Pro Leu Val Ala Ile Ala Gln Arg Leu Tyr 
        755                 760                 765             


Ala Met Ala Ala Pro Glu Asn Tyr Arg Ile His Tyr Cys Val Tyr His 
    770                 775                 780                 


Ser Gln His Pro Leu Ala Val Arg Ser Ala Ile Glu Arg Arg Leu Asp 
785                 790                 795                 800 


Val Thr Leu Thr Arg Tyr Gln Pro Asn Ala Leu Trp Gln Val Ala Glu 
                805                 810                 815     


Ile Glu His Ala Leu Gln His His Pro Glu Gln His His Leu Phe Val 
            820                 825                 830         


Val Leu Ala Thr Ser Val Val Glu Val Gly Arg Asp His Asp Tyr Asp 
        835                 840                 845             


Trp Ala Leu Ala Glu Pro Ser Ser Met Arg Ser Phe Ile Gln Leu Ala 
    850                 855                 860                 


Gly Arg Val Gln Arg His Arg Gln Val Ala Pro Gln Met Ala Asn Met 
865                 870                 875                 880 


His Ile Leu Gln Lys Asn Phe Lys Ala Leu Thr Gln Lys Asp Pro Ala 
                885                 890                 895     


Ile Pro Val Tyr Cys Lys Pro Gly Phe Glu Thr Thr Arg Cys Arg Leu 
            900                 905                 910         


Asn Thr His Asp Leu Asp Lys Leu Leu Leu Pro Ser Gln Tyr Lys Val 
        915                 920                 925             


Ile Asn Ala Ile Ser Arg Ile Gln Glu Arg Thr Lys Leu Glu Pro Arg 
    930                 935                 940                 


Asp Asn Phe Val Asp Leu Glu His Leu Ser Leu Arg Leu Ile Leu Gln 
945                 950                 955                 960 


Gly Ser Ala Glu Pro Leu Lys Tyr Tyr Ala Ala Leu Trp Trp Arg Lys 
                965                 970                 975     


Gln Ala Thr Trp Ser Gly Glu Gln Gln Arg Cys Thr Pro Phe Arg Gln 
            980                 985                 990         


Ser Ser Pro Asp Glu Gln His Asn  Leu Trp Ile Asp Asp  Glu Ala Asp 
        995                 1000                 1005             


Lys Pro  Val Phe Lys Arg Leu  Asp Ser Asp Gln Ile  Glu Trp Lys 
    1010                 1015                 1020             


Val Ser  Asp Gly Phe Gln Asp  Val Glu Leu Thr Leu  Ala Val Gly 
    1025                 1030                 1035             


Asn Ser  Ala Trp Ile Asp Thr  Asp Cys Leu Arg Ile  Tyr Gln Trp 
    1040                 1045                 1050             


Leu Ala  Glu Ser Leu Asn Lys  Glu Leu Asn Glu Val  Ser Arg Gln 
    1055                 1060                 1065             


Phe Gly  Glu Val Arg Leu Pro  Lys Lys Asp Gly Glu  Arg Trp His 
    1070                 1075                 1080             


Tyr His  Pro Leu Leu Gly Gly  Phe Gly Ala Leu Asp  
    1085                 1090                 1095 


<210>  36
<211>  448
<212>  PRT
<213>  Yersinia pseudotuberculosis


<220>
<221>  PEPTIDE
<222>  (1)..(448)
<223>  type I-F CRISPR-associated protein Csy1: WP_012303963.1

<400>  36

Met Glu Glu Lys Gly Leu Thr Ala Phe Ile Val Ser Tyr Ile Lys Ser 
1               5                   10                  15      


Arg Glu Gln Pro Lys Leu Glu Ala Phe Asp Lys Glu Ala Glu Lys Arg 
            20                  25                  30          


Leu Ala Gly Leu Thr Gln Ala Glu Asp Ile Ala Leu Ala Gln Gln Glu 
        35                  40                  45              


Ile Ala Gln Gln Arg Gln Glu Leu Val Ala Arg Tyr Glu Val Arg Asn 
    50                  55                  60                  


Trp Leu Thr Asp Ala Ala Asn Arg Ala Gly Gln Ile Ser Leu Val Thr 
65                  70                  75                  80  


His Ala Leu Lys Phe Thr His Ser Asp Ala Lys Gly Ser Ser Val Phe 
                85                  90                  95      


Asn Leu Pro Ala Ala Glu Asn Asp Ala Ile Tyr Leu Ser Ser Ala Thr 
            100                 105                 110         


Leu Gly Gln Pro Ala Val Asp Ala Val Gly Asn Ala Ala Ala Leu Asp 
        115                 120                 125             


Val Ala Lys Leu Leu Gln Thr Glu His Asn Gly Asp Ser Leu Leu Ala 
    130                 135                 140                 


Cys Leu Asn Arg Ala Asp Asn Ser Pro Leu Ala Ala Leu Ala Glu Asn 
145                 150                 155                 160 


Pro Gln Gln Leu Ala Leu Trp Val Glu Gly Phe Lys Gln Ala Leu Val 
                165                 170                 175     


Asp Lys Gln Leu Thr Ser His Lys Leu Ala Lys Gln Phe Tyr Phe Pro 
            180                 185                 190         


Val Gly Pro Asp Gln Tyr His Leu Leu Ser Pro Leu Phe Ser Ser Ser 
        195                 200                 205             


Leu Ala Gln Ala Met His Gln Arg Ile Ala Glu Ala Arg Phe Ser Asp 
    210                 215                 220                 


Gln Ser Lys Glu Ala Lys Val Ala His Lys Ala Gly Lys Trp His Ser 
225                 230                 235                 240 


Glu Ala Arg Val Ile Tyr Leu Lys Thr Ala Val Gln Asn Ile Gly Gly 
                245                 250                 255     


Thr Lys Pro Gln Asn Ile Ser Tyr Leu Asn Ser Val Arg Gly Gly Lys 
            260                 265                 270         


Val Trp Leu Leu Pro Cys Gly Ala Pro Pro Trp Lys Asn Ile Gln Lys 
        275                 280                 285             


Pro Pro Ile Lys Tyr Arg Ser Ile Phe His Asp Arg Ser Glu Phe Thr 
    290                 295                 300                 


Val Leu Ala Arg Asn Asn Leu Trp Gln Met Gln Gln Tyr Leu Leu Gly 
305                 310                 315                 320 


Val Lys Pro Leu Ser Asn Thr Met Asp Ile Arg Ala Val Arg Leu Ala 
                325                 330                 335     


Cys Ser Asp Glu Ile Ile Asp Ile Leu Phe Asn Tyr Val Ala Glu Ile 
            340                 345                 350         


Gln Asn Leu Asp Gly Thr Asn Gly Trp Ser Asp Ala Glu Asp Cys Lys 
        355                 360                 365             


Leu Lys Arg Ser Glu Gln Leu Trp Leu Asp Pro Asn Arg Ala Met Asp 
    370                 375                 380                 


Asp Pro Val Phe Lys Leu Glu Arg Glu Lys Glu Asp Trp Lys Gln Glu 
385                 390                 395                 400 


Val Ser Gln Asp Phe Gly Tyr Trp Leu Asn Arg Trp Leu Gln His Asp 
                405                 410                 415     


Glu Leu Val Phe Gly Tyr Val Glu Gln Arg Glu Trp Ser Ser Leu Phe 
            420                 425                 430         


Lys Gln Arg Leu Arg Glu Phe Glu Gln Gly Ser Leu Glu Thr Trp Ser 
        435                 440                 445             


<210>  37
<211>  316
<212>  PRT
<213>  Yersinia pseudotuberculosis


<220>
<221>  PEPTIDE
<222>  (1)..(316)
<223>  type I-F CRISPR-associated protein Csy2: WP_012303964.1

<400>  37

Met Ser Ser Leu Ile Val Leu His Gln Val Arg Val Glu Asn Ala Asn 
1               5                   10                  15      


Ala Ile Ala Gly Leu Thr Tyr Gly Phe Pro Ala Ile Thr His Phe Leu 
            20                  25                  30          


Gly Tyr Ser His Ala Leu Ser Arg Lys Leu Gln Ser Ser His Gly Leu 
        35                  40                  45              


Thr Leu Arg Gly Cys Ala Val Ile Cys His His Gln Gln Val His Ala 
    50                  55                  60                  


Tyr Ser Ser Gly Arg Asp Tyr Val Phe Ser Leu Thr Arg Asn Pro Leu 
65                  70                  75                  80  


Thr Lys Glu Ala Lys Thr Ala Ala Phe Asn Glu Glu Gly Arg Met His 
                85                  90                  95      


Met Thr Val Ser Leu Val Ile Glu Cys Asp Gly Thr Ile Ala Asn Gly 
            100                 105                 110         


Asp Asp Gly Ala Asn Ala Leu Glu Lys His Leu Ala Ser Leu Cys Leu 
        115                 120                 125             


Thr Gln Arg Leu Ala Gly Gly Thr Ile Thr Asn Ile Arg Arg Val Lys 
    130                 135                 140                 


Val Ile Asn Tyr Pro Glu Thr Glu Ala Ala Thr Arg Arg Leu Leu Cys 
145                 150                 155                 160 


His Leu Leu Pro Gly Phe Ala Leu Leu Asp Arg Ser Glu Leu Leu Ala 
                165                 170                 175     


Glu His Leu Asn Gln Leu Arg Gln Thr Asn Pro Gln Thr Glu Met Leu 
            180                 185                 190         


Asp Ala Trp Leu Asp Phe Ser Ala Leu Lys Ile Gln Ala Ile Pro Pro 
        195                 200                 205             


Gln Ser Asp Thr Pro Val Glu Ser Gly Ala Pro Ala Pro Trp Gly Tyr 
    210                 215                 220                 


Val Gly Lys Pro Ala Ala Gly Tyr Leu Val Pro Ile Val Thr Gly Tyr 
225                 230                 235                 240 


Arg Ala Ile Ser Pro Leu Tyr Ala Pro Gly Glu Val Asp Lys Thr Arg 
                245                 250                 255     


Asp Pro His Thr Pro Phe Arg Phe Val Glu Ser Leu Tyr Gly Ile Gly 
            260                 265                 270         


Glu Trp Arg Gly Leu His Arg Ile Thr Asp Leu Arg Gln Leu Leu Trp 
        275                 280                 285             


Gly Tyr His Gln Glu Gly Asp Asn Tyr Leu Cys Arg Cys Ala Leu Pro 
    290                 295                 300                 


Ala Ser Val Asp Thr Tyr Leu Leu Asn Asp Glu Glu 
305                 310                 315     


<210>  38
<211>  334
<212>  PRT
<213>  Yersinia pseudotuberculosis


<220>
<221>  PEPTIDE
<222>  (1)..(334)
<223>  type I-F CRISPR-associated protein Csy3: WP_011192624.1

<400>  38

Met Ala Lys Ala Thr Ile Lys Thr Ala Ser Val Leu Ala Phe Glu Arg 
1               5                   10                  15      


Lys Leu Ser Asn Ser Asp Ala Met Met Tyr Ala Gly Asn Trp Gly Gln 
            20                  25                  30          


Thr Asp Asn Trp Gln Pro Ile Ile Ile Lys Glu Lys Ala Val Arg Gly 
        35                  40                  45              


Thr Ile Ser Asn Arg Leu Lys Asn Ala Leu Ala Ser Asp Pro Val Lys 
    50                  55                  60                  


Leu Asp Ala Glu Ile Gln Lys Ala Asn Leu Gln Arg Val Asp Val Ala 
65                  70                  75                  80  


Ala Leu Pro Phe Asp Thr Asp Thr Leu Lys Met Ser Phe Thr Leu Arg 
                85                  90                  95      


Val Leu Gly Asn Leu Ala Thr Pro Ser Val Cys Asn Asp Gln Glu Tyr 
            100                 105                 110         


Gln Ala Glu Leu Ala Ser Val Ile Asn Gly Tyr Ile Ser Glu Gln Ser 
        115                 120                 125             


Phe Ser Val Leu Ala Ala Arg Tyr Ala Glu Asn Leu Ala Asn Gly Arg 
    130                 135                 140                 


Phe Leu Trp Arg Asn Arg Val Gly Ala Glu Asp Ile Lys Val Cys Ile 
145                 150                 155                 160 


Thr Ser Gln Thr Lys Ser Tyr Gln Phe Asp Ser Asn Glu Phe Ser Leu 
                165                 170                 175     


Arg Gln Phe Ser Gln Pro Ser Lys Glu Leu Thr Ala Leu Ala Gln Glu 
            180                 185                 190         


Ile Glu Gln Gly Leu Ala Gly Asn Gly Phe Ala Phe Phe Thr Val Asp 
        195                 200                 205             


Ala Phe Val Arg Leu Gly Asn Gly Gln Glu Val Phe Pro Ser Gln Glu 
    210                 215                 220                 


Leu Val Leu Asp Ser Asn Ser Lys Lys Ser Lys Val Leu Tyr Gln Ile 
225                 230                 235                 240 


Asp Gly Ile Ala Ala Leu His Ser Gln Lys Val Gly Asn Ala Leu Arg 
                245                 250                 255     


Thr Ile Asp Asp Trp Tyr Pro Asp Ala Thr Glu Leu Ala Leu Gly Pro 
            260                 265                 270         


Ile Ala Val Glu Pro Tyr Gly Ser Val Thr Ser Arg Gly Lys Ala Tyr 
        275                 280                 285             


Arg Gln Pro Lys Gln Lys Met Asp Phe Tyr Thr Leu Leu Asp Asn Trp 
    290                 295                 300                 


Val Thr Lys Gly Thr Val Pro Ala Val Glu Gln Gln His Tyr Val Met 
305                 310                 315                 320 


Ala Thr Leu Ile Arg Gly Gly Val Phe Gly Glu Lys Gly Glu 
                325                 330                 


<210>  39
<211>  184
<212>  PRT
<213>  Yersinia pseudotuberculosis


<220>
<221>  PEPTIDE
<222>  (1)..(184)
<223>  type I-F CRISPR-associated endoribonuclease  Cas6/Csy4:  
       WP_002211866.1

<400>  39

Met Asp His Tyr Leu Asp Ile Arg Val Leu Pro Asp Pro Glu Phe Ser 
1               5                   10                  15      


Ala Gln Thr Leu Leu Glu Ala Leu Phe Ala Lys Leu His Arg Ala Leu 
            20                  25                  30          


Val Ala Thr Ile Pro Gly Arg Val Gly Val Ser Phe Pro Thr Ala Gly 
        35                  40                  45              


Lys Thr Leu Gly Ser Gln Leu Arg Leu His Gly Ser Arg Gly Asp Leu 
    50                  55                  60                  


Leu Glu Leu Gln Ser Ala Gly Trp Leu Lys Gly Leu Gln Asp Tyr Cys 
65                  70                  75                  80  


Glu Cys Ser Glu Ile Leu Pro Val Pro Ala Asp Val Lys His Arg Thr 
                85                  90                  95      


Ile Arg Arg Val Gln Val Lys Ser Ser Ala Gln Arg Leu Arg Arg Arg 
            100                 105                 110         


Ser Val Ser Lys Gly Trp Leu Thr Glu Glu Gln Ala Arg Leu Arg Ile 
        115                 120                 125             


Pro Asp Ser His Asp Lys Arg Cys Asp Leu Pro Phe Leu Arg Leu Lys 
    130                 135                 140                 


Ser Arg Ser Ser Glu Gln Tyr Phe Leu Leu Phe Ile Glu Gln Gly Thr 
145                 150                 155                 160 


Leu Gln Ala Ser Ala Thr Thr Gly Glu Phe Ser Ala Tyr Gly Leu Ser 
                165                 170                 175     


Val Asn Ala Thr Ile Pro Trp Phe 
            180                 


<210>  40
<211>  325
<212>  PRT
<213>  Shewanella putrefaciens


<220>
<221>  PEPTIDE
<222>  (1)..(325)
<223>  type I-F CRISPR-associated endonuclease Cas1:WP_011789486.1

<400>  40

Met Asp Asp Phe Ser Pro Ser Asp Leu Lys Thr Ile Leu His Ser Lys 
1               5                   10                  15      


Arg Ala Asn Met Tyr Tyr Leu Glu Tyr Cys Arg Val Met Gln Lys Asp 
            20                  25                  30          


Gly Arg Val Leu Tyr Leu Thr Glu Ala Lys Asn Glu Asn Gln Tyr Phe 
        35                  40                  45              


Asn Ile Pro Ile Ala Asn Thr Thr Val Leu Leu Leu Gly Asn Gly Thr 
    50                  55                  60                  


Ser Ile Thr Gln Ala Ala Met Arg Met Leu Ala Gln Ala Gly Val Leu 
65                  70                  75                  80  


Val Gly Phe Cys Gly Gly Gly Gly Thr Pro Leu Tyr Met Thr Cys Glu 
                85                  90                  95      


Val Glu Trp Leu Thr Pro Gln Ser Glu Tyr Arg Pro Thr Glu Tyr Leu 
            100                 105                 110         


His Gly Trp Met Gln Phe Trp Phe Asp Asp Glu Lys Arg Leu Leu Ala 
        115                 120                 125             


Ala Lys Thr Phe Gln Gln Ala Arg Ile Gln Phe Ile Glu Gln Val Trp 
    130                 135                 140                 


Gln Arg Asp Arg Glu Leu Lys Thr Glu Gly Phe Ile Phe Lys Asp Pro 
145                 150                 155                 160 


Ala Ile Gln Ala Ala Leu Glu Thr Phe His Ala Arg Thr Glu Ala Ala 
                165                 170                 175     


Thr Lys Gln Ser Asp Leu Leu Leu Thr Glu Ala Gln Leu Thr Lys Val 
            180                 185                 190         


Leu Tyr Lys His Ala Ala Asn Asn Thr Gln Leu Lys Asp Phe Thr Arg 
        195                 200                 205             


Gln His Gln Ser Ala Asp Ile Ala Asn Asp Phe Leu Asn His Gly Asn 
    210                 215                 220                 


Tyr Leu Ala Tyr Gly Leu Ala Ala Ser Cys Leu Trp Val Leu Gly Ile 
225                 230                 235                 240 


Pro His Gly Phe Ala Val Met His Gly Lys Thr Arg Arg Gly Ala Leu 
                245                 250                 255     


Val Phe Asp Val Ala Asp Leu Ile Lys Asp Ala Ile Val Leu Pro Trp 
            260                 265                 270         


Ala Phe Val Cys Ala Lys Glu Lys Ala Ser Glu Gln Glu Phe Arg Gln 
        275                 280                 285             


Gln Val Leu Gln Ala Phe Thr Asp His Asn Ala Leu Asp Phe Met Phe 
    290                 295                 300                 


Asn Thr Val Lys Gly Ile Ala Leu Gln Asp Tyr Ser Ala Glu Gln Ile 
305                 310                 315                 320 


Ala Ala Gln Gly Leu 
                325 


<210>  41
<211>  978
<212>  PRT
<213>  Shewanella putrefaciens


<220>
<221>  PEPTIDE
<222>  (1)..(978)
<223>  CRISPR-associated endonuclease Cas3'': WP_000989810.1

<400>  41

Met Met Val Thr Phe Ile Ser Gln Cys Glu Lys Asn Ala Leu Lys Lys 
1               5                   10                  15      


Thr Arg Arg Val Leu Asp Ala Phe Ala Asn Arg Ile Gly Asp Asn Thr 
            20                  25                  30          


Trp Gln Thr Leu Ile Thr Glu Asp Gly Leu Leu Thr Val Lys Lys Met 
        35                  40                  45              


Leu Lys Gln Thr Ala Ser Lys Ser Thr Ala Val Ser Cys His Trp Ile 
    50                  55                  60                  


Arg Ser Arg Ala Arg Ser Gln Leu Leu Trp Val Val Gly Asn Arg Leu 
65                  70                  75                  80  


Lys Phe Asn Glu Gln Gly Ile Val Pro Val Asn Ser Thr Val Lys Glu 
                85                  90                  95      


Val Phe Met Asp Val Val Thr Asn Lys Pro Lys Gln Gly Val Leu Tyr 
            100                 105                 110         


Ala Asn Thr Gln Leu Gln Pro Leu Ser Glu His Leu Phe Ala Val Gly 
        115                 120                 125             


Phe Val Ala Glu Leu Leu His Arg Gln Leu Phe Pro Glu Asn Thr Gln 
    130                 135                 140                 


Phe Ser Ile Ala Asn Phe Ile Ala Gly Cys Leu His Asp Leu Gly Lys 
145                 150                 155                 160 


Ile Asp Pro Lys Phe Gln Glu Trp Val Thr Asn Pro Lys Lys Arg Asp 
                165                 170                 175     


Phe Ile Ala Glu Asp Gly Gln His Ile Asp Asp Ala Lys Phe Ser Phe 
            180                 185                 190         


Asp Lys His Pro Arg His Asn Glu Val Ser Leu Leu Leu Tyr Gln Leu 
        195                 200                 205             


Leu Asp Ser Thr Glu Leu Lys Leu Leu Asn Pro Ser Asn Lys Arg Ser 
    210                 215                 220                 


Val Lys His Ala Leu Tyr Trp His His Ala Lys Pro Phe Arg Lys Glu 
225                 230                 235                 240 


Lys Asn Gly Phe Asp Thr Tyr Lys Asp Ile Ser Lys Lys Leu Val Ala 
                245                 250                 255     


Asn Gln Lys Glu Ile Gly Leu Ser Asp Ile Val Gly Gln Ala Gln Thr 
            260                 265                 270         


Leu Leu Arg Gln Val Ile Gly Ile Asp Lys Lys Tyr Arg Glu Leu Thr 
        275                 280                 285             


Asn Arg Leu Leu Glu Lys Ala Phe Leu Ala Glu Val Glu Gln Asp Leu 
    290                 295                 300                 


Glu Ala Asn Leu Pro Asp Ala Pro Ala Leu Pro Ser Tyr Lys Glu Tyr 
305                 310                 315                 320 


Glu Phe Glu Glu Ser Val Ser Ala Asn Ser Thr Asn Val Lys Leu Asn 
                325                 330                 335     


Ala Leu Asn Asn Ile Val Arg Ala Cys Leu Ile Ser Ala Asp Arg Thr 
            340                 345                 350         


Val Ser Ala Leu Ser Ala Ala Glu Leu His Thr Ala Ile Phe Glu Arg 
        355                 360                 365             


Gln Leu Glu Glu Ile Val Thr Glu Leu Leu Glu Val Glu Thr Thr Leu 
    370                 375                 380                 


Ser Ser Asp Ile Asp Thr Cys Leu Asn Ala Phe Phe Pro Thr Ser Glu 
385                 390                 395                 400 


Arg Ser Gln Lys Gln Arg Asp Ile Ala Lys Gln Leu Thr Thr Ala Glu 
                405                 410                 415     


Asp Val Ala Val Leu Ala Gly Ala Ala Gly Cys Gly Lys Thr Lys Ile 
            420                 425                 430         


Ala Leu Glu Trp Ala Lys Leu Gln Gly Val Lys Arg Ile Ile Trp Val 
        435                 440                 445             


Cys Pro Arg Val Gln Val Cys Gln Gly Leu Phe Tyr Glu Leu Thr Ser 
    450                 455                 460                 


Glu Gln Tyr Leu Pro Asn Ser Thr Ile Glu Ile Asn Thr Gly Glu Phe 
465                 470                 475                 480 


Lys Phe His Asn Gln Trp Asp Asn Pro Ile Pro Asp Asp Glu Asn Phe 
                485                 490                 495     


Ser Gly Asp Ile Val Leu Thr Thr Ile Asp Gln Ile Leu Gly Ser Val 
            500                 505                 510         


Ile Ser His Thr Lys Ala Asn Thr Leu Ile Asp Phe Leu Asn Val His 
        515                 520                 525             


Val Val Phe Asp Glu Phe His Glu Tyr Val Asn Met Pro Ala Phe Asn 
    530                 535                 540                 


Leu Leu Phe Ala Glu Leu Ile Ala Ala Lys Lys Met Gln Lys Asp Gln 
545                 550                 555                 560 


Ala Lys Thr Leu Leu Val Ser Ala Thr Pro His Tyr Val Phe Val Glu 
                565                 570                 575     


Asp Leu Leu Gly Ile His Pro Asp Asp Ile Lys Ile Met Pro Ser Phe 
            580                 585                 590         


Asn Pro Ser Gln Tyr Gln Leu Asp Phe Lys Ile Phe Asp Asp Thr Asn 
        595                 600                 605             


Leu Ser Asn Ile Asn Pro Leu Phe Ala Gln Gln Ser Gly Cys Thr Phe 
    610                 615                 620                 


Val Ile Ser Asn Met Ala Leu Thr Ala Gln Asn Ser Phe Ile Val Asn 
625                 630                 635                 640 


Gln His Asn Glu Asn Ala Val Leu Leu His Ser Lys Phe Ile Lys Ser 
                645                 650                 655     


Asp Lys Arg Lys Trp Phe Gly Glu Val Tyr Glu Ala Tyr Lys Arg Asp 
            660                 665                 670         


Gly Thr Arg Lys Tyr Glu Val Leu Arg Ser Gly Pro Ile Val Gln Ala 
        675                 680                 685             


Ser Leu Asn Ile Ser Cys Asp Tyr Met Val Ala Glu Ile Thr Ser Ala 
    690                 695                 700                 


Glu Asp Cys Leu Gln Arg Leu Gly Arg Leu Asp Arg Phe Gly Glu Asn 
705                 710                 715                 720 


Ser Asp Val Asn Thr Tyr Thr Leu Ala Val Pro Glu Ser Ile Ala Asn 
                725                 730                 735     


Gly Lys Gly Lys Ser Pro Ala Ala Gly Phe Leu Ser Lys Met Tyr Ala 
            740                 745                 750         


Leu Ser Ser Val Arg Ala Trp Tyr Gln Phe Leu His Ser Glu Leu Ala 
        755                 760                 765             


Asp Lys Thr Phe Thr Leu Pro Glu Ile Tyr Gln Leu Tyr Phe Ala Phe 
    770                 775                 780                 


His His Thr Glu Arg Asn Arg Gly Phe Ile Ala Ser Asp Leu Val Ala 
785                 790                 795                 800 


Ala Leu Lys Asn Ser Val Gln Gln Ile Asn Ala Lys Val Val Asp Pro 
                805                 810                 815     


Ile Thr Val Pro Pro Lys Asn Asn Lys Asp Lys Lys Arg Thr Lys Ile 
            820                 825                 830         


Ser Lys Gly Ser Leu Arg Gly Asp Asn Arg Phe Val Gln Leu Ala Val 
        835                 840                 845             


Val Asp Leu Ser Gln Ala Glu Pro Lys Tyr Ile Glu Ala Tyr Ala Tyr 
    850                 855                 860                 


Ser Ile Pro Leu Asp Asp Asp Ser Asn Ile Asp Asn Leu Thr Tyr Ala 
865                 870                 875                 880 


Thr Lys Ala Ile Cys Gly Tyr Asp Gln Ser Asp Lys Asp Leu Leu Ser 
                885                 890                 895     


His Met Phe Lys Lys His His Asn Ile Met Gly Gly Thr Gly Lys Ala 
            900                 905                 910         


Phe Thr Asp Lys Ile Leu Leu Asn Glu Ala Arg Asp Pro Glu Ser Pro 
        915                 920                 925             


Ile Tyr Leu Ser Tyr Thr Thr Asn Asp Leu Leu Gln Val Gly Gly Glu 
    930                 935                 940                 


Ser Ala Arg His Pro His Ala Ile Tyr Tyr Ala Val Cys Asp Lys Gln 
945                 950                 955                 960 


Ala Ile Gly Ala Met Ser Ile Lys Gln Ile Asn Gln Thr Thr Glu Asp 
                965                 970                 975     


Glu Glu 
        


<210>  42
<211>  315
<212>  PRT
<213>  Shewanella putrefaciens


<220>
<221>  PEPTIDE
<222>  (1)..(315)
<223>  hypothetical protein: WP_011919225.1

<400>  42

Met Gln Lys Val Thr Gly Ile Lys Ser Val Asp Phe Lys Ile Lys Ala 
1               5                   10                  15      


Leu Gly His Gly Val Val Asn Trp Asn Gly Pro Thr Thr Leu Thr Gly 
            20                  25                  30          


Asp Asp Gly Lys Thr Val Asp Asn His Thr Leu Pro Lys Leu Arg Gly 
        35                  40                  45              


Tyr Thr Asn Leu Thr Gly Lys Val Lys Asp Glu Thr Gly Tyr Lys Tyr 
    50                  55                  60                  


Lys Lys Gln Ala Thr Asp Ile Asn Phe Lys Glu Thr Pro Leu Tyr Ile 
65                  70                  75                  80  


Ser Gln Asn Cys Ile Arg His His Leu Phe Arg Glu Gln Ala Phe Asp 
                85                  90                  95      


Leu His Tyr Ala Ser Asp Lys Asn Leu Lys Asn Val Leu Ala Ser Ile 
            100                 105                 110         


Thr Gly Leu Ile Arg Gly Tyr Val Val Pro Ser Ser Gln Cys Lys Arg 
        115                 120                 125             


Thr Ser Pro Leu Leu Leu Glu Asp Phe Val Asp Gln Leu Gly Asn Gly 
    130                 135                 140                 


Asn Phe Glu Gln Tyr Gly Gln Ala Gly Ala Arg Asp Ser Thr Ser Phe 
145                 150                 155                 160 


Phe Ser Lys Thr Thr Phe Gly Asp Thr Glu Tyr Ile Ser Tyr Gly Ser 
                165                 170                 175     


Ile Ser Ile Glu Gln Leu Gln Phe Ile Ser Leu Asp Lys Lys Phe Asp 
            180                 185                 190         


Arg Ala Ala Met Val Ile Lys Glu Gly Glu Gly Glu Val Ile Ala Ala 
        195                 200                 205             


Glu Leu Gln Asn Tyr Ile Gln Ser Leu Asn Pro Ser Leu Asn Pro Gln 
    210                 215                 220                 


Ala Ile Phe His Ser Asn Tyr Val Arg Arg Gly Thr Ile Phe Glu Glu 
225                 230                 235                 240 


Gly Glu Cys Gly Ile Leu Leu Asn Asp Asp Ala Val Lys Ala Leu Val 
                245                 250                 255     


Ala Glu Thr Leu Glu Arg Leu Ala Asn Leu Ser Ile Arg Gln Ala Lys 
            260                 265                 270         


Gly Tyr Met Tyr Val Asp Asp Ile Thr Val Asp Tyr Asn Asp Ser His 
        275                 280                 285             


Lys Met Met Arg Ile Lys Arg Asp Glu Ser Glu Ile Ile Asn Glu Gln 
    290                 295                 300                 


His Ala Pro Phe Ala Gln Tyr Phe Tyr Ala Lys 
305                 310                 315 


<210>  43
<211>  336
<212>  PRT
<213>  Shewanella putrefaciens


<220>
<221>  PEPTIDE
<222>  (1)..(336)
<223>  hypothetical protein WP_011919226.1

<400>  43

Met Lys Ile Ile Ile Glu Tyr Asp Ser Cys Trp Arg Asn Ala Phe Leu 
1               5                   10                  15      


Gly Gly Ser Asn Asn Glu Pro Val Pro Lys Lys Gly Arg Glu Phe Leu 
            20                  25                  30          


Gly Ser Met Thr Ser Leu Lys Lys Glu Gly Asn Phe Lys Val Cys Glu 
        35                  40                  45              


Asn Thr Leu Asp Thr Val Met Gly Val Leu Asn Arg Leu Ile Gly Asp 
    50                  55                  60                  


Gln Arg Lys Leu Tyr Gln Ala Arg Ser Lys Met Tyr Glu Ser Ala Tyr 
65                  70                  75                  80  


Tyr Phe Glu Ala Leu Glu Asp Lys Val Ser Phe Ile Asp Lys Pro Gln 
                85                  90                  95      


Leu Thr Asn Glu Ile Ser Phe Ile Arg Asn Met Asn Gly Ser Thr Asp 
            100                 105                 110         


Gln Asn Ala Phe Thr Gly Met Ile Lys Val Ser Asp Pro Val Phe Thr 
        115                 120                 125             


Ser Glu Tyr Ser Gln Gln Phe Trp Gly Val Leu Ala Leu Asp Phe Thr 
    130                 135                 140                 


Gln Leu Cys Asp Phe Ile Ile Lys Gln Ser Gln Val Val Gly Ser Ile 
145                 150                 155                 160 


Glu Leu Asn Pro Leu Ser Ile Ile Asn Arg Leu Glu Ser Leu Asn Gln 
                165                 170                 175     


Glu Lys Ala Leu Glu Asn Ser Asp Asp Leu Ala Gln Val Leu Lys Val 
            180                 185                 190         


Leu Asn Glu Tyr Phe Pro Asp Ile Glu Tyr Leu Asn Asn Lys Gly Leu 
        195                 200                 205             


Ile Thr Pro Ile Ser Ile Tyr Cys Ser Ala Leu Tyr Leu Gln Leu Ala 
    210                 215                 220                 


Arg Leu Glu Thr Ser Phe Asn Met Thr Thr Ala Lys Thr Lys Ala Gly 
225                 230                 235                 240 


Gly Ile Ser Gly Ile Ser Lys Arg Gly Phe Thr Lys Lys Asp Phe Met 
                245                 250                 255     


Asp Arg Tyr Thr Thr Gly Pro Lys Lys Thr Ile Trp Gly Asn Pro Phe 
            260                 265                 270         


Ile Lys Lys Glu Lys Ile Lys Gly Gln Gly Glu Val Thr Ser Met Met 
        275                 280                 285             


Thr Lys Ala Ser Gly Gln Leu Glu Ile Ser Ile Asp Val Asp Arg Asp 
    290                 295                 300                 


Lys Ala Gln Glu Ile Lys Ile Leu Ile Glu Asn Ala Gly Val Ser Ser 
305                 310                 315                 320 


Phe Tyr Leu Gly Lys Lys Gly Leu Ala Tyr Val Ser Asn Ile Lys Leu 
                325                 330                 335     


<210>  44
<211>  183
<212>  PRT
<213>  Shewanella putrefaciens


<220>
<221>  PEPTIDE
<222>  (1)..(183)
<223>  type I-F CRISPR-associated endoribonuclease  Cas6/Csy4: 
       WP_011919227.1

<400>  44

Met Asn Ser Tyr Ile Asp Ile Arg Leu Lys Pro Asp Ala Glu Met Arg 
1               5                   10                  15      


Glu Ala Glu Leu Ser Ser Lys Val Phe Thr Lys Phe His Lys Ala Leu 
            20                  25                  30          


Val Thr Leu Asn Ser His Lys Ile Gly Ile Ser Phe Pro Gln Met Lys 
        35                  40                  45              


Leu Ser Leu Gly Gln Leu Phe Arg Ile His Gly Asp Ala Ser Leu Leu 
    50                  55                  60                  


His Asp Leu Gln Gly Leu Asp Trp Leu Gly Pro Leu Ala Gly Tyr Cys 
65                  70                  75                  80  


Gln Val Thr Ala Val Ser Ala Val Pro Asp His Val Gln Tyr Arg Ile 
                85                  90                  95      


Val Ser Val Lys Arg Ser Asn Leu Ser Lys Ala Lys Leu Lys Arg Leu 
            100                 105                 110         


Ile Ala Arg Gly Ser Ile Asp Lys Asp Gly Glu Lys Arg Tyr Lys Val 
        115                 120                 125             


Lys Met Leu Gly Gln Gly Phe Asp Asn Pro Tyr Leu Asp Leu Phe Ser 
    130                 135                 140                 


Ser Ser Thr Gly Gln Val Tyr Arg Lys Phe Phe Glu Phe Ser Asp Ile 
145                 150                 155                 160 


Gln Ala His Pro Leu Asp Gly Glu Phe Asp Ser Tyr Gly Leu Ser Lys 
                165                 170                 175     


Thr Ala Thr Val Pro Trp Phe 
            180             


<210>  45
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  PEPTIDE
<222>  (1)..(1368)
<223>  type II CRISPR RNA-guided endonuclease Cas9: WP_020905136.1

<400>  45

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Leu Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  46
<211>  1372
<212>  PRT
<213>  Legionella pneumophila


<220>
<221>  PEPTIDE
<222>  (1)..(1372)
<223>  type II-B CRISPR-associated RNA-guided endonuclease Cas9/Csx12: 
       WP_011212792.1

<400>  46

Met Glu Ser Ser Gln Ile Leu Ser Pro Ile Gly Ile Asp Leu Gly Gly 
1               5                   10                  15      


Lys Phe Thr Gly Val Cys Leu Ser His Leu Glu Ala Phe Ala Glu Leu 
            20                  25                  30          


Pro Asn His Ala Asn Thr Lys Tyr Ser Val Ile Leu Ile Asp His Asn 
        35                  40                  45              


Asn Phe Gln Leu Ser Gln Ala Gln Arg Arg Ala Thr Arg His Arg Val 
    50                  55                  60                  


Arg Asn Lys Lys Arg Asn Gln Phe Val Lys Arg Val Ala Leu Gln Leu 
65                  70                  75                  80  


Phe Gln His Ile Leu Ser Arg Asp Leu Asn Ala Lys Glu Glu Thr Ala 
                85                  90                  95      


Leu Cys His Tyr Leu Asn Asn Arg Gly Tyr Thr Tyr Val Asp Thr Asp 
            100                 105                 110         


Leu Asp Glu Tyr Ile Lys Asp Glu Thr Thr Ile Asn Leu Leu Lys Glu 
        115                 120                 125             


Leu Leu Pro Ser Glu Ser Glu His Asn Phe Ile Asp Trp Phe Leu Gln 
    130                 135                 140                 


Lys Met Gln Ser Ser Glu Phe Arg Lys Ile Leu Val Ser Lys Val Glu 
145                 150                 155                 160 


Glu Lys Lys Asp Asp Lys Glu Leu Lys Asn Ala Val Lys Asn Ile Lys 
                165                 170                 175     


Asn Phe Ile Thr Gly Phe Glu Lys Asn Ser Val Glu Gly His Arg His 
            180                 185                 190         


Arg Lys Val Tyr Phe Glu Asn Ile Lys Ser Asp Ile Thr Lys Asp Asn 
        195                 200                 205             


Gln Leu Asp Ser Ile Lys Lys Lys Ile Pro Ser Val Cys Leu Ser Asn 
    210                 215                 220                 


Leu Leu Gly His Leu Ser Asn Leu Gln Trp Lys Asn Leu His Arg Tyr 
225                 230                 235                 240 


Leu Ala Lys Asn Pro Lys Gln Phe Asp Glu Gln Thr Phe Gly Asn Glu 
                245                 250                 255     


Phe Leu Arg Met Leu Lys Asn Phe Arg His Leu Lys Gly Ser Gln Glu 
            260                 265                 270         


Ser Leu Ala Val Arg Asn Leu Ile Gln Gln Leu Glu Gln Ser Gln Asp 
        275                 280                 285             


Tyr Ile Ser Ile Leu Glu Lys Thr Pro Pro Glu Ile Thr Ile Pro Pro 
    290                 295                 300                 


Tyr Glu Ala Arg Thr Asn Thr Gly Met Glu Lys Asp Gln Ser Leu Leu 
305                 310                 315                 320 


Leu Asn Pro Glu Lys Leu Asn Asn Leu Tyr Pro Asn Trp Arg Asn Leu 
                325                 330                 335     


Ile Pro Gly Ile Ile Asp Ala His Pro Phe Leu Glu Lys Asp Leu Glu 
            340                 345                 350         


His Thr Lys Leu Arg Asp Arg Lys Arg Ile Ile Ser Pro Ser Lys Gln 
        355                 360                 365             


Asp Glu Lys Arg Asp Ser Tyr Ile Leu Gln Arg Tyr Leu Asp Leu Asn 
    370                 375                 380                 


Lys Lys Ile Asp Lys Phe Lys Ile Lys Lys Gln Leu Ser Phe Leu Gly 
385                 390                 395                 400 


Gln Gly Lys Gln Leu Pro Ala Asn Leu Ile Glu Thr Gln Lys Glu Met 
                405                 410                 415     


Glu Thr His Phe Asn Ser Ser Leu Val Ser Val Leu Ile Gln Ile Ala 
            420                 425                 430         


Ser Ala Tyr Asn Lys Glu Arg Glu Asp Ala Ala Gln Gly Ile Trp Phe 
        435                 440                 445             


Asp Asn Ala Phe Ser Leu Cys Glu Leu Ser Asn Ile Asn Pro Pro Arg 
    450                 455                 460                 


Lys Gln Lys Ile Leu Pro Leu Leu Val Gly Ala Ile Leu Ser Glu Asp 
465                 470                 475                 480 


Phe Ile Asn Asn Lys Asp Lys Trp Ala Lys Phe Lys Ile Phe Trp Asn 
                485                 490                 495     


Thr His Lys Ile Gly Arg Thr Ser Leu Lys Ser Lys Cys Lys Glu Ile 
            500                 505                 510         


Glu Glu Ala Arg Lys Asn Ser Gly Asn Ala Phe Lys Ile Asp Tyr Glu 
        515                 520                 525             


Glu Ala Leu Asn His Pro Glu His Ser Asn Asn Lys Ala Leu Ile Lys 
    530                 535                 540                 


Ile Ile Gln Thr Ile Pro Asp Ile Ile Gln Ala Ile Gln Ser His Leu 
545                 550                 555                 560 


Gly His Asn Asp Ser Gln Ala Leu Ile Tyr His Asn Pro Phe Ser Leu 
                565                 570                 575     


Ser Gln Leu Tyr Thr Ile Leu Glu Thr Lys Arg Asp Gly Phe His Lys 
            580                 585                 590         


Asn Cys Val Ala Val Thr Cys Glu Asn Tyr Trp Arg Ser Gln Lys Thr 
        595                 600                 605             


Glu Ile Asp Pro Glu Ile Ser Tyr Ala Ser Arg Leu Pro Ala Asp Ser 
    610                 615                 620                 


Val Arg Pro Phe Asp Gly Val Leu Ala Arg Met Met Gln Arg Leu Ala 
625                 630                 635                 640 


Tyr Glu Ile Ala Met Ala Lys Trp Glu Gln Ile Lys His Ile Pro Asp 
                645                 650                 655     


Asn Ser Ser Leu Leu Ile Pro Ile Tyr Leu Glu Gln Asn Arg Phe Glu 
            660                 665                 670         


Phe Glu Glu Ser Phe Lys Lys Ile Lys Gly Ser Ser Ser Asp Lys Thr 
        675                 680                 685             


Leu Glu Gln Ala Ile Glu Lys Gln Asn Ile Gln Trp Glu Glu Lys Phe 
    690                 695                 700                 


Gln Arg Ile Ile Asn Ala Ser Met Asn Ile Cys Pro Tyr Lys Gly Ala 
705                 710                 715                 720 


Ser Ile Gly Gly Gln Gly Glu Ile Asp His Ile Tyr Pro Arg Ser Leu 
                725                 730                 735     


Ser Lys Lys His Phe Gly Val Ile Phe Asn Ser Glu Val Asn Leu Ile 
            740                 745                 750         


Tyr Cys Ser Ser Gln Gly Asn Arg Glu Lys Lys Glu Glu His Tyr Leu 
        755                 760                 765             


Leu Glu His Leu Ser Pro Leu Tyr Leu Lys His Gln Phe Gly Thr Asp 
    770                 775                 780                 


Asn Val Ser Asp Ile Lys Asn Phe Ile Ser Gln Asn Val Ala Asn Ile 
785                 790                 795                 800 


Lys Lys Tyr Ile Ser Phe His Leu Leu Thr Pro Glu Gln Gln Lys Ala 
                805                 810                 815     


Ala Arg His Ala Leu Phe Leu Asp Tyr Asp Asp Glu Ala Phe Lys Thr 
            820                 825                 830         


Ile Thr Lys Phe Leu Met Ser Gln Gln Lys Ala Arg Val Asn Gly Thr 
        835                 840                 845             


Gln Lys Phe Leu Gly Lys Gln Ile Met Glu Phe Leu Ser Thr Leu Ala 
    850                 855                 860                 


Asp Ser Lys Gln Leu Gln Leu Glu Phe Ser Ile Lys Gln Ile Thr Ala 
865                 870                 875                 880 


Glu Glu Val His Asp His Arg Glu Leu Leu Ser Lys Gln Glu Pro Lys 
                885                 890                 895     


Leu Val Lys Ser Arg Gln Gln Ser Phe Pro Ser His Ala Ile Asp Ala 
            900                 905                 910         


Thr Leu Thr Met Ser Ile Gly Leu Lys Glu Phe Pro Gln Phe Ser Gln 
        915                 920                 925             


Glu Leu Asp Asn Ser Trp Phe Ile Asn His Leu Met Pro Asp Glu Val 
    930                 935                 940                 


His Leu Asn Pro Val Arg Ser Lys Glu Lys Tyr Asn Lys Pro Asn Ile 
945                 950                 955                 960 


Ser Ser Thr Pro Leu Phe Lys Asp Ser Leu Tyr Ala Glu Arg Phe Ile 
                965                 970                 975     


Pro Val Trp Val Lys Gly Glu Thr Phe Ala Ile Gly Phe Ser Glu Lys 
            980                 985                 990         


Asp Leu Phe Glu Ile Lys Pro Ser  Asn Lys Glu Lys Leu  Phe Thr Leu 
        995                 1000                 1005             


Leu Lys  Thr Tyr Ser Thr Lys  Asn Pro Gly Glu Ser  Leu Gln Glu 
    1010                 1015                 1020             


Leu Gln  Ala Lys Ser Lys Ala  Lys Trp Leu Tyr Phe  Pro Ile Asn 
    1025                 1030                 1035             


Lys Thr  Leu Ala Leu Glu Phe  Leu His His Tyr Phe  His Lys Glu 
    1040                 1045                 1050             


Ile Val  Thr Pro Asp Asp Thr  Thr Val Cys His Phe  Ile Asn Ser 
    1055                 1060                 1065             


Leu Arg  Tyr Tyr Thr Lys Lys  Glu Ser Ile Thr Val  Lys Ile Leu 
    1070                 1075                 1080             


Lys Glu  Pro Met Pro Val Leu  Ser Val Lys Phe Glu  Ser Ser Lys 
    1085                 1090                 1095             


Lys Asn  Val Leu Gly Ser Phe  Lys His Thr Ile Ala  Leu Pro Ala 
    1100                 1105                 1110             


Thr Lys  Asp Trp Glu Arg Leu  Phe Asn His Pro Asn  Phe Leu Ala 
    1115                 1120                 1125             


Leu Lys  Ala Asn Pro Ala Pro  Asn Pro Lys Glu Phe  Asn Glu Phe 
    1130                 1135                 1140             


Ile Arg  Lys Tyr Phe Leu Ser  Asp Asn Asn Pro Asn  Ser Asp Ile 
    1145                 1150                 1155             


Pro Asn  Asn Gly His Asn Ile  Lys Pro Gln Lys His  Lys Ala Val 
    1160                 1165                 1170             


Arg Lys  Val Phe Ser Leu Pro  Val Ile Pro Gly Asn  Ala Gly Thr 
    1175                 1180                 1185             


Met Met  Arg Ile Arg Arg Lys  Asp Asn Lys Gly Gln  Pro Leu Tyr 
    1190                 1195                 1200             


Gln Leu  Gln Thr Ile Asp Asp  Thr Pro Ser Met Gly  Ile Gln Ile 
    1205                 1210                 1215             


Asn Glu  Asp Arg Leu Val Lys  Gln Glu Val Leu Met  Asp Ala Tyr 
    1220                 1225                 1230             


Lys Thr  Arg Asn Leu Ser Thr  Ile Asp Gly Ile Asn  Asn Ser Glu 
    1235                 1240                 1245             


Gly Gln  Ala Tyr Ala Thr Phe  Asp Asn Trp Leu Thr  Leu Pro Val 
    1250                 1255                 1260             


Ser Thr  Phe Lys Pro Glu Ile  Ile Lys Leu Glu Met  Lys Pro His 
    1265                 1270                 1275             


Ser Lys  Thr Arg Arg Tyr Ile  Arg Ile Thr Gln Ser  Leu Ala Asp 
    1280                 1285                 1290             


Phe Ile  Lys Thr Ile Asp Glu  Ala Leu Met Ile Lys  Pro Ser Asp 
    1295                 1300                 1305             


Ser Ile  Asp Asp Pro Leu Asn  Met Pro Asn Glu Ile  Val Cys Lys 
    1310                 1315                 1320             


Asn Lys  Leu Phe Gly Asn Glu  Leu Lys Pro Arg Asp  Gly Lys Met 
    1325                 1330                 1335             


Lys Ile  Val Ser Thr Gly Lys  Ile Val Thr Tyr Glu  Phe Glu Ser 
    1340                 1345                 1350             


Asp Ser  Thr Pro Gln Trp Ile  Gln Thr Leu Tyr Val  Thr Gln Leu 
    1355                 1360                 1365             


Lys Lys  Gln Pro 
    1370         


<210>  47
<211>  1082
<212>  PRT
<213>  Neisseria meningitidis


<220>
<221>  PEPTIDE
<222>  (1)..(1082)
<223>  type II CRISPR RNA-guided endonuclease Cas9: WP_014574210.1

<400>  47

Met Ala Ala Phe Lys Pro Asn Ser Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asn 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Gly Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Ser Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Leu Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210>  48
<211>  244
<212>  PRT
<213>  Staphylococcus epidermidis


<220>
<221>  PEPTIDE
<222>  (1)..(244)
<223>  CRISPR-associated endoribonuclease Cas6: WP_002486027.1

<400>  48

Met Ile Asn Lys Ile Thr Val Glu Leu Asp Leu Pro Glu Ser Ile Arg 
1               5                   10                  15      


Phe Gln Tyr Leu Gly Ser Val Leu His Gly Val Leu Met Asp Tyr Leu 
            20                  25                  30          


Ser Asp Asp Ile Ala Asp Gln Leu His His Glu Phe Ala Tyr Ser Pro 
        35                  40                  45              


Leu Lys Gln Arg Ile Tyr His Lys Asn Lys Lys Ile Ile Trp Glu Ile 
    50                  55                  60                  


Val Cys Met Ser Asp Asn Leu Phe Lys Glu Val Val Lys Leu Phe Ser 
65                  70                  75                  80  


Ser Lys Asn Ser Leu Leu Leu Lys Tyr Tyr Gln Thr Asn Ile Asp Ile 
                85                  90                  95      


Gln Ser Phe Gln Ile Glu Lys Ile Asn Val Gln Asn Met Met Asn Gln 
            100                 105                 110         


Leu Leu Gln Val Glu Asp Leu Ser Arg Tyr Val Arg Leu Asn Ile Gln 
        115                 120                 125             


Thr Pro Met Ser Phe Lys Tyr Gln Asn Ser Tyr Met Ile Phe Pro Asp 
    130                 135                 140                 


Val Lys Arg Phe Phe Arg Ser Ile Met Ile Gln Phe Asp Ala Phe Phe 
145                 150                 155                 160 


Glu Glu Tyr Arg Met Tyr Asp Lys Glu Thr Leu Asn Phe Leu Glu Lys 
                165                 170                 175     


Asn Val Asn Ile Val Asp Tyr Lys Leu Lys Ser Thr Arg Phe Asn Leu 
            180                 185                 190         


Glu Lys Val Lys Ile Pro Ser Phe Thr Gly Glu Ile Val Phe Lys Ile 
        195                 200                 205             


Lys Gly Pro Leu Pro Phe Leu Gln Leu Thr His Phe Leu Leu Lys Phe 
    210                 215                 220                 


Gly Glu Phe Ser Gly Ser Gly Ile Lys Thr Ser Leu Gly Met Gly Lys 
225                 230                 235                 240 


Tyr Ser Ile Ile 
                


<210>  49
<211>  422
<212>  PRT
<213>  Staphylococcus epidermidis


<220>
<221>  PEPTIDE
<222>  (1)..(422)
<223>  type III-A CRISPR-associated protein Csm6: WP_002486034.1

<400>  49

Met Lys Ile Leu Phe Ser Pro Ile Gly Asn Ser Asp Pro Trp Arg Asn 
1               5                   10                  15      


Asp Arg Asp Gly Ala Met Leu His Ile Val Arg His Tyr Asn Leu Asp 
            20                  25                  30          


Lys Val Val Leu Tyr Phe Thr Arg Thr Ile Trp Glu Gly Asn Glu Asn 
        35                  40                  45              


Arg Lys Gly His Lys Ile Tyr Glu Trp Glu Lys Ile Ile Gln Thr Val 
    50                  55                  60                  


Ser Pro Asn Thr Glu Val Glu Ile Ile Ile Glu Asn Val Asp Asn Ala 
65                  70                  75                  80  


Gln Asp Tyr Asp Val Phe Lys Glu Lys Phe His Lys Tyr Leu Lys Ile 
                85                  90                  95      


Ile Glu Asp Ser Tyr Glu Asp Cys Glu Ile Ile Leu Asn Val Thr Ser 
            100                 105                 110         


Gly Thr Pro Gln Met Glu Ser Thr Leu Cys Leu Glu Tyr Ile Val Tyr 
        115                 120                 125             


Pro Glu Asn Lys Lys Cys Val Gln Val Ser Thr Pro Thr Lys Asp Ser 
    130                 135                 140                 


Asn Ala Gly Ile Glu Tyr Ser Asn Pro Lys Asp Lys Val Glu Glu Phe 
145                 150                 155                 160 


Glu Ile Val Asn Glu Val Glu Lys Lys Ser Glu Lys Arg Cys Lys Glu 
                165                 170                 175     


Ile Asn Ile Leu Ser Phe Arg Glu Ala Met Ile Arg Ser Gln Ile Leu 
            180                 185                 190         


Gly Leu Ile Asp Asn Tyr Asp Tyr Glu Gly Ala Leu Asn Leu Val Ser 
        195                 200                 205             


Asn Gln Lys Ser Phe Arg Asn Gly Lys Leu Leu Arg Lys Lys Leu Leu 
    210                 215                 220                 


Ser Leu Thr Lys Gln Ile Lys Thr His Glu Val Phe Pro Glu Ile Asn 
225                 230                 235                 240 


Glu Lys Tyr Arg Asp Asp Ala Leu Lys Lys Ser Leu Phe His Tyr Leu 
                245                 250                 255     


Leu Leu Asn Met Arg Tyr Asn Arg Leu Asp Val Ala Glu Thr Leu Ile 
            260                 265                 270         


Arg Val Lys Ser Ile Ala Glu Phe Ile Leu Lys Thr Tyr Ile Glu Ile 
        275                 280                 285             


His Trp Pro Thr Leu Ile Ile Glu Lys Asp Gly Lys Pro Tyr Leu Asn 
    290                 295                 300                 


Asp Glu Asp Asn Leu Ser Phe Val Tyr Lys Tyr Asn Leu Leu Leu Glu 
305                 310                 315                 320 


Lys Arg Lys Gln Asn Phe Asp Val Ser Arg Ile Leu Gly Leu Pro Ala 
                325                 330                 335     


Phe Ile Asp Ile Leu Thr Ile Leu Glu Pro Asn Ser Gln Leu Leu Lys 
            340                 345                 350         


Glu Val Asn Ala Val Asn Asp Ile Asn Gly Leu Arg Asn Ser Ile Ala 
        355                 360                 365             


His Asn Leu Asp Thr Leu Asn Leu Asp Lys Asn Lys Asn Tyr Lys Lys 
    370                 375                 380                 


Ile Met Leu Ser Val Glu Ala Ile Lys Asn Met Leu His Ile Ser Phe 
385                 390                 395                 400 


Pro Glu Ile Glu Glu Glu Asp Tyr Asn Tyr Phe Glu Glu Lys Asn Lys 
                405                 410                 415     


Glu Phe Lys Glu Leu Leu 
            420         


<210>  50
<211>  340
<212>  PRT
<213>  Staphylococcus epidermidis


<220>
<221>  PEPTIDE
<222>  (1)..(340)
<223>  type III-A CRISPR-associated RAMP protein Csm5: WP_002486031.1

<400>  50

Met Thr Ile Lys Asn Tyr Glu Val Val Ile Lys Thr Leu Gly Pro Ile 
1               5                   10                  15      


His Ile Gly Ser Gly Gln Val Met Lys Lys Gln Asp Tyr Ile Tyr Asp 
            20                  25                  30          


Phe Tyr Asn Ser Lys Val Tyr Met Ile Asn Gly Asn Lys Leu Val Lys 
        35                  40                  45              


Phe Leu Lys Arg Lys Asn Leu Leu Tyr Thr Tyr Gln Asn Phe Leu Arg 
    50                  55                  60                  


Tyr Pro Pro Lys Asn Pro Arg Glu Asn Gly Leu Lys Asp Tyr Leu Asp 
65                  70                  75                  80  


Ala Gln Asn Val Lys Gln Ser Glu Trp Glu Ala Phe Val Ser Tyr Ser 
                85                  90                  95      


Glu Lys Val Asn Gln Gly Lys Lys Tyr Gly Asn Thr Arg Pro Lys Pro 
            100                 105                 110         


Leu Asn Asp Leu His Leu Met Val Arg Asp Gly Gln Asn Lys Val Tyr 
        115                 120                 125             


Leu Pro Gly Ser Ser Ile Lys Gly Ala Ile Lys Thr Thr Leu Val Ser 
    130                 135                 140                 


Lys Tyr Asn Asn Glu Lys Asn Lys Asp Ile Tyr Ser Lys Ile Lys Val 
145                 150                 155                 160 


Ser Asp Ser Lys Pro Ile Asp Glu Ser Asn Leu Ala Ile Tyr Gln Lys 
                165                 170                 175     


Ile Asp Ile Asn Lys Ser Glu Lys Ser Met Pro Leu Tyr Arg Glu Cys 
            180                 185                 190         


Ile Asp Val Asn Thr Glu Ile Lys Phe Lys Leu Thr Ile Glu Asp Glu 
        195                 200                 205             


Ile Tyr Ser Ile Asn Glu Ile Glu Gln Ser Ile Gln Asp Phe Tyr Lys 
    210                 215                 220                 


Asn Tyr Tyr Asp Lys Trp Leu Val Gly Phe Lys Glu Thr Lys Gly Gly 
225                 230                 235                 240 


Arg Arg Phe Ala Leu Glu Gly Gly Ile Pro Asp Val Leu Asn Gln Asn 
                245                 250                 255     


Ile Leu Phe Leu Gly Ala Gly Thr Gly Phe Val Ser Lys Thr Thr His 
            260                 265                 270         


Tyr Gln Leu Lys Asn Arg Lys Gln Ala Lys Gln Asp Ser Phe Glu Ile 
        275                 280                 285             


Leu Thr Lys Lys Phe Arg Gly Thr Tyr Gly Lys Met Lys Glu Ile Pro 
    290                 295                 300                 


Ser Asn Val Pro Val Ala Leu Lys Gly Thr Thr Asn Gln Ser Arg His 
305                 310                 315                 320 


Thr Ser Tyr Gln Gln Gly Met Cys Lys Val Ser Phe Gln Glu Leu Asn 
                325                 330                 335     


Asn Glu Val Leu 
            340 


<210>  51
<211>  302
<212>  PRT
<213>  Staphylococcus epidermidis


<220>
<221>  PEPTIDE
<222>  (1)..(302)
<223>  type III-A CRISPR-associated RAMP protein Csm4: WP_002486041.1

<400>  51

Met Ala Thr Lys Val Phe Lys Leu Ser Phe Lys Thr Pro Val His Phe 
1               5                   10                  15      


Gly Lys Lys Arg Leu Ser Asp Gly Glu Met Thr Ile Thr Ala Asp Thr 
            20                  25                  30          


Leu Phe Ser Ala Leu Phe Ile Glu Thr Leu Gln Leu Gly Lys Asp Thr 
        35                  40                  45              


Asp Trp Leu Leu Asn Asp Leu Ile Ile Ser Asp Thr Phe Pro Tyr Glu 
    50                  55                  60                  


Asn Glu Leu Tyr Tyr Leu Pro Lys Pro Leu Ile Lys Ile Asp Ser Lys 
65                  70                  75                  80  


Glu Glu Asp Asn His Lys Ala Phe Lys Lys Leu Lys Tyr Val Pro Val 
                85                  90                  95      


His His Tyr Asn Gln Tyr Leu Asn Gly Glu Leu Ser Ala Glu Asp Ala 
            100                 105                 110         


Thr Asp Leu Asn Asp Ile Phe Asn Ile Gly Tyr Phe Ser Leu Gln Thr 
        115                 120                 125             


Lys Val Ser Leu Ile Ala Gln Glu Thr Asp Ser Ser Ala Asp Ser Glu 
    130                 135                 140                 


Pro Tyr Ser Val Gly Thr Phe Thr Phe Glu Pro Glu Ala Gly Leu Tyr 
145                 150                 155                 160 


Phe Ile Ala Lys Gly Ser Glu Glu Thr Leu Asp His Leu Asn Asn Ile 
                165                 170                 175     


Met Thr Ala Leu Gln Tyr Ser Gly Leu Gly Gly Lys Arg Asn Ala Gly 
            180                 185                 190         


Tyr Gly Gln Phe Glu Tyr Glu Ile Ile Asn Asn Gln Gln Leu Ser Lys 
        195                 200                 205             


Leu Leu Asn Gln Asn Gly Lys His Ser Ile Leu Leu Ser Thr Ala Met 
    210                 215                 220                 


Ala Lys Lys Glu Glu Ile Glu Ser Ala Leu Lys Glu Ala Arg Tyr Ile 
225                 230                 235                 240 


Leu Thr Lys Arg Ser Gly Phe Val Gln Ser Thr Asn Tyr Ser Glu Met 
                245                 250                 255     


Leu Val Lys Lys Ser Asp Phe Tyr Ser Phe Ser Ser Gly Ser Val Phe 
            260                 265                 270         


Lys Asn Ile Phe Asn Gly Asp Ile Phe Asn Val Gly His Asn Gly Lys 
        275                 280                 285             


His Pro Val Tyr Arg Tyr Ala Lys Pro Leu Trp Leu Glu Val 
    290                 295                 300         


<210>  52
<211>  214
<212>  PRT
<213>  Staphylococcus epidermidis


<220>
<221>  PEPTIDE
<222>  (1)..(214)
<223>  type III-A CRISPR-associated RAMP protein Csm3: WP_002486018.1

<400>  52

Met Tyr Ser Lys Ile Lys Ile Ser Gly Thr Ile Glu Val Val Thr Gly 
1               5                   10                  15      


Leu His Ile Gly Gly Gly Gly Glu Ser Ser Met Ile Gly Ala Ile Asp 
            20                  25                  30          


Ser Pro Val Val Arg Asp Leu Gln Thr Lys Leu Pro Ile Ile Pro Gly 
        35                  40                  45              


Ser Ser Ile Lys Gly Lys Met Arg Asn Leu Leu Ala Lys His Phe Gly 
    50                  55                  60                  


Leu Lys Met Lys Gln Glu Ser His Asn Gln Asp Asp Glu Arg Val Leu 
65                  70                  75                  80  


Arg Leu Phe Gly Ser Ser Glu Lys Gly Asn Ile Gln Arg Ala Arg Leu 
                85                  90                  95      


Gln Ile Ser Asp Ala Phe Phe Ser Glu Lys Thr Lys Glu His Phe Ala 
            100                 105                 110         


Gln Asn Asp Ile Ala Tyr Thr Glu Thr Lys Phe Glu Asn Thr Ile Asn 
        115                 120                 125             


Arg Leu Thr Ala Val Ala Asn Pro Arg Gln Ile Glu Arg Val Thr Arg 
    130                 135                 140                 


Gly Ser Glu Phe Asp Phe Val Phe Ile Tyr Asn Val Asp Glu Glu Ser 
145                 150                 155                 160 


Gln Val Glu Asp Asp Phe Glu Asn Ile Glu Lys Ala Ile His Leu Leu 
                165                 170                 175     


Glu Asn Asp Tyr Leu Gly Gly Gly Gly Thr Arg Gly Asn Gly Arg Ile 
            180                 185                 190         


Gln Phe Lys Asp Thr Asn Ile Glu Thr Val Val Gly Glu Tyr Asp Ser 
        195                 200                 205             


Thr Asn Leu Lys Ile Lys 
    210                 


<210>  53
<211>  141
<212>  PRT
<213>  Staphylococcus epidermidis


<220>
<221>  PEPTIDE
<222>  (1)..(141)
<223>  type III-A CRISPR-associated protein Csm2 
       /protein_id="WP_002486044.1"

<400>  53

Met Ile Leu Ala Lys Thr Lys Ser Gly Lys Thr Ile Asp Leu Thr Phe 
1               5                   10                  15      


Ala His Glu Val Val Lys Ser Asn Val Lys Asn Val Lys Asp Arg Lys 
            20                  25                  30          


Gly Lys Glu Lys Gln Val Leu Phe Asn Gly Leu Thr Thr Ser Lys Leu 
        35                  40                  45              


Arg Asn Leu Met Glu Gln Val Asn Arg Leu Tyr Thr Ile Ala Phe Asn 
    50                  55                  60                  


Ser Asn Glu Asp Gln Leu Asn Glu Glu Phe Ile Asp Glu Leu Glu Tyr 
65                  70                  75                  80  


Leu Lys Ile Lys Phe Tyr Tyr Glu Ala Gly Arg Glu Lys Ser Val Asp 
                85                  90                  95      


Glu Phe Leu Lys Lys Thr Leu Met Phe Pro Ile Ile Asp Arg Val Ile 
            100                 105                 110         


Lys Lys Glu Ser Lys Lys Phe Phe Leu Asp Tyr Cys Lys Tyr Phe Glu 
        115                 120                 125             


Ala Leu Val Ala Tyr Ala Lys Tyr Tyr Gln Lys Glu Asp 
    130                 135                 140     


<210>  54
<211>  757
<212>  PRT
<213>  Staphylococcus epidermidis


<220>
<221>  PEPTIDE
<222>  (1)..(757)
<223>  type III-A CRISPR-associated protein Cas10/Csm1 
       /protein_id=WP_002486045.1

<400>  54

Met Asn Lys Lys Asn Ile Leu Met Tyr Gly Ser Leu Leu His Asp Ile 
1               5                   10                  15      


Gly Lys Ile Ile Tyr Arg Ser Gly Asp His Thr Phe Ser Arg Gly Thr 
            20                  25                  30          


His Ser Lys Leu Gly His Gln Phe Leu Ser Gln Phe Ser Glu Phe Lys 
        35                  40                  45              


Asp Asn Glu Val Leu Asp Asn Val Ala Tyr His His Tyr Lys Glu Leu 
    50                  55                  60                  


Ala Lys Ala Asn Leu Asp Asn Asp Asn Thr Ala Tyr Ile Thr Tyr Ile 
65                  70                  75                  80  


Ala Asp Asn Ile Ala Ser Gly Ile Asp Arg Arg Asp Ile Ile Glu Glu 
                85                  90                  95      


Gly Asp Glu Glu Tyr Glu Lys Gln Leu Phe Asn Phe Asp Lys Tyr Thr 
            100                 105                 110         


Pro Leu Tyr Ser Val Phe Asn Ile Val Asn Ser Glu Lys Leu Lys Gln 
        115                 120                 125             


Thr Asn Gly Lys Phe Lys Phe Ser Asn Glu Ser Asn Ile Glu Tyr Pro 
    130                 135                 140                 


Lys Thr Glu Asn Ile Gln Tyr Ser Ser Gly Asn Tyr Thr Thr Leu Met 
145                 150                 155                 160 


Lys Asp Met Ser His Asp Leu Glu His Lys Leu Ser Ile Lys Glu Gly 
                165                 170                 175     


Thr Phe Pro Ser Leu Leu Gln Trp Thr Glu Ser Leu Trp Gln Tyr Val 
            180                 185                 190         


Pro Ser Ser Thr Asn Lys Asn Gln Leu Ile Asp Ile Ser Leu Tyr Asp 
        195                 200                 205             


His Ser Arg Ile Thr Cys Ala Ile Ala Ser Cys Ile Phe Asp Tyr Leu 
    210                 215                 220                 


Asn Glu Asn Asn Ile His Asn Tyr Lys Asp Glu Leu Phe Ser Lys Tyr 
225                 230                 235                 240 


Glu Asn Thr Lys Ser Phe Tyr Gln Lys Glu Ala Phe Leu Leu Leu Ser 
                245                 250                 255     


Met Asp Met Ser Gly Ile Gln Asp Phe Ile Tyr Asn Ile Ser Gly Ser 
            260                 265                 270         


Lys Ala Leu Lys Ser Leu Arg Ser Arg Ser Phe Tyr Leu Glu Leu Met 
        275                 280                 285             


Leu Glu Val Ile Val Asp Gln Leu Leu Glu Arg Leu Glu Leu Ala Arg 
    290                 295                 300                 


Ala Asn Leu Leu Tyr Thr Gly Gly Gly His Ala Tyr Leu Leu Val Ser 
305                 310                 315                 320 


Asn Thr Asp Lys Val Lys Lys Lys Ile Thr Gln Phe Asn Asn Glu Leu 
                325                 330                 335     


Lys Lys Trp Phe Met Ser Glu Phe Thr Thr Asp Leu Ser Leu Ser Met 
            340                 345                 350         


Ala Phe Glu Lys Cys Ser Gly Asp Asp Leu Met Asn Thr Ser Gly Asn 
        355                 360                 365             


Tyr Arg Thr Ile Trp Arg Asn Val Ser Ser Lys Leu Ser Asp Ile Lys 
    370                 375                 380                 


Ala His Lys Tyr Ser Ala Glu Asp Ile Leu Lys Leu Asn His Phe His 
385                 390                 395                 400 


Ser Tyr Gly Asp Arg Glu Cys Lys Glu Cys Leu Arg Ser Asp Ile Asp 
                405                 410                 415     


Ile Asn Asp Asp Gly Leu Cys Ser Ile Cys Glu Gly Ile Ile Asn Ile 
            420                 425                 430         


Ser Asn Asp Leu Arg Asp Lys Ser Phe Phe Val Leu Ser Glu Thr Gly 
        435                 440                 445             


Lys Leu Lys Met Pro Phe Asn Lys Phe Ile Ser Val Ile Asp Tyr Glu 
    450                 455                 460                 


Glu Ala Glu Met Leu Val Gln Asn Asn Asn Gln Val Arg Ile Tyr Ser 
465                 470                 475                 480 


Lys Asn Lys Pro Tyr Ile Gly Ile Gly Ile Ser Thr Asn Leu Trp Met 
                485                 490                 495     


Cys Asp Tyr Asp Tyr Ala Ser Gln Asn Gln Asp Met Arg Glu Lys Gly 
            500                 505                 510         


Ile Gly Ser Tyr Val Asp Arg Glu Glu Gly Val Lys Arg Leu Gly Val 
        515                 520                 525             


Val Arg Ala Asp Ile Asp Asn Leu Gly Ala Thr Phe Ile Ser Gly Ile 
    530                 535                 540                 


Pro Glu Lys Tyr Asn Ser Ile Ser Arg Thr Ala Thr Leu Ser Arg Gln 
545                 550                 555                 560 


Leu Ser Leu Phe Phe Lys Tyr Glu Leu Asn His Leu Leu Glu Asn Tyr 
                565                 570                 575     


Gln Ile Thr Ala Ile Tyr Ser Gly Gly Asp Asp Leu Phe Leu Ile Gly 
            580                 585                 590         


Ala Trp Asp Asp Ile Ile Glu Ala Ser Ile Tyr Ile Asn Asp Lys Phe 
        595                 600                 605             


Lys Glu Phe Thr Leu Asp Lys Leu Thr Leu Ser Ala Gly Val Gly Met 
    610                 615                 620                 


Phe Ser Gly Lys Tyr Pro Val Ser Lys Met Ala Phe Glu Thr Gly Arg 
625                 630                 635                 640 


Leu Glu Glu Ala Ala Lys Thr Gly Glu Lys Asn Gln Ile Ser Leu Trp 
                645                 650                 655     


Leu Gln Glu Lys Val Tyr Asn Trp Asp Glu Phe Lys Lys Asn Ile Leu 
            660                 665                 670         


Glu Glu Lys Leu Leu Val Leu Gln Gln Gly Phe Ser Gln Thr Asp Glu 
        675                 680                 685             


His Gly Lys Ala Phe Ile Tyr Lys Met Leu Ala Leu Leu Arg Asn Asn 
    690                 695                 700                 


Glu Ala Ile Asn Ile Ala Arg Leu Ala Tyr Leu Leu Ala Arg Ser Lys 
705                 710                 715                 720 


Met Asn Glu Asp Phe Thr Ser Lys Ile Phe Asn Trp Ala Gln Asn Asp 
                725                 730                 735     


Lys Asp Lys Asn Gln Leu Ile Thr Ala Leu Glu Tyr Tyr Ile Tyr Gln 
            740                 745                 750         


Ile Arg Glu Ala Asp 
        755         


<210>  55
<211>  101
<212>  PRT
<213>  Staphylococcus epidermidis


<220>
<221>  PEPTIDE
<222>  (1)..(101)
<223>  CRISPR-associated endonuclease Cas2 /protein_id=WP_002469399.1

<400>  55

Met Tyr Leu Leu Val Ser Phe Asp Leu Pro Arg Asp Thr Lys Leu Glu 
1               5                   10                  15      


Arg Arg Ile Ala Ser Lys Tyr Arg Leu Arg Leu Ile Glu Leu Gly Phe 
            20                  25                  30          


Ser Met Lys Gln Phe Ser Leu Tyr Glu Arg Tyr Val Ser Asn Val Gln 
        35                  40                  45              


Lys Lys Asp Lys Ile Leu Glu Ile Leu Lys Gln Glu Ile Pro Asp Thr 
    50                  55                  60                  


Gly Ser Ile Thr Leu Tyr Ile Leu Pro Asp Glu Val Asn Ser Asn Gln 
65                  70                  75                  80  


Ile Thr Ile Leu Gly Lys Glu Val Lys Leu Ala Val Asn Lys Glu Pro 
                85                  90                  95      


Lys Leu Ile Phe Ile 
            100     


<210>  56
<211>  301
<212>  PRT
<213>  Staphylococcus epidermidis


<220>
<221>  PEPTIDE
<222>  (1)..(301)
<223>  type II CRISPR-associated endonuclease Cas1: 
       /protein_id=WP_002486040.1

<400>  56

Met Lys Asp Val Ile Tyr Val Glu Asn His Tyr Phe Val Thr Ala Lys 
1               5                   10                  15      


Glu Asn Ser Ile Lys Phe Arg Asn Val Ile Asp Lys Ser Glu Lys Phe 
            20                  25                  30          


Tyr Leu Phe Glu Glu Ile Glu Ala Ile Ile Phe Asp His Tyr Lys Ser 
        35                  40                  45              


Tyr Phe Ser His Lys Leu Val Ile Lys Cys Ile Glu Asn Asp Ile Ala 
    50                  55                  60                  


Ile Ile Phe Cys Asp Lys Lys His Ser Pro Val Thr Gln Leu Ile Ser 
65                  70                  75                  80  


Ser Tyr Gly Met Val Asn Arg Leu Lys Arg Ile Gln Ser Gln Phe Gln 
                85                  90                  95      


Leu Ser Gly Arg Thr Lys Asp Arg Ile Trp Lys Lys Ile Val Ile Asn 
            100                 105                 110         


Lys Ile Phe Asn Gln Thr Arg Cys Leu Glu Asn Asn Leu His Asn Glu 
        115                 120                 125             


Asn Val Lys Leu Met Leu Gly Phe Ala Lys Glu Val Ser Ser Gly Asp 
    130                 135                 140                 


Lys Ser Asn Lys Glu Ala His Ala Thr Arg Ile Tyr Phe Lys Asp Leu 
145                 150                 155                 160 


Phe Gly Lys Gln Phe Lys Arg Gly Arg Tyr Asn Asp Val Ile Asn Ser 
                165                 170                 175     


Gly Leu Asn Tyr Gly Tyr Ser Ile Leu Arg Ser Phe Ile Asn Lys Glu 
            180                 185                 190         


Leu Ala Ile His Gly Phe Glu Met Ser Leu Gly Ile Lys His Gln Ser 
        195                 200                 205             


Lys Glu Asn Pro Phe Asn Leu Ala Asp Asp Ile Ile Glu Val Phe Arg 
    210                 215                 220                 


Pro Phe Val Asp Asn Ile Val Tyr Glu Ile Val Phe Lys Lys Asn Ile 
225                 230                 235                 240 


Asp Thr Phe Asp Ile Asn Glu Lys Lys Leu Leu Leu Asn Val Leu Tyr 
                245                 250                 255     


Glu Arg Cys Ile Ile Asp Lys Lys Val Val Arg Leu Leu Asp Ser Val 
            260                 265                 270         


Lys Ile Val Ile Gln Ser Leu Ile Arg Cys Tyr Glu Glu Asn Thr Pro 
        275                 280                 285             


Thr Tyr Leu Leu Leu Pro Lys Met Ile Glu Val Gly Asn 
    290                 295                 300     


<210>  57
<211>  340
<212>  PRT
<213>  Pyrococcus furiosus


<220>
<221>  PEPTIDE
<222>  (1)..(340)
<223>  type III-B CRISPR module RAMP protein Cmr6: 
       /protein_id=WP_011012264.1

<400>  57

Met Lys Glu Val Val Lys Leu Val Leu Leu Gly Glu Arg Gln Asn Ser 
1               5                   10                  15      


Leu Asn Leu Ser Leu Tyr Phe Asn Lys Tyr Pro Pro Thr Ile Ile Tyr 
            20                  25                  30          


Pro Glu Val Leu Glu Asp Arg Asn Lys Lys Leu Ala Ser Pro Ser Gly 
        35                  40                  45              


Ser Gln Arg Lys Ile Ser Leu Leu Val Leu Asn Gln Gly Val Leu Gln 
    50                  55                  60                  


Phe Asn Lys Ile Lys Glu Thr Ile Glu Lys Ser Leu Pro Ile Glu Thr 
65                  70                  75                  80  


Lys Val Lys Leu Pro Gln Lys Ala Tyr Glu Leu Tyr Lys Lys Tyr Tyr 
                85                  90                  95      


Gln Asp Tyr Thr Asp Met Leu Asn Ser Leu His Ala Ile Thr Gly Lys 
            100                 105                 110         


Phe Lys Thr Gln Ser Arg Leu Val Val Gly Leu Gly Asp Glu Ser Val 
        115                 120                 125             


Tyr Glu Thr Ser Ile Arg Leu Leu Arg Asn Tyr Gly Val Pro Tyr Ile 
    130                 135                 140                 


Pro Gly Ser Ala Ile Lys Gly Val Thr Arg His Leu Thr Tyr Tyr Val 
145                 150                 155                 160 


Leu Ala Glu Phe Ile Asn Glu Gly Asn Asp Phe Tyr Lys Arg Ala Lys 
                165                 170                 175     


Thr Val Gln Asp Ala Phe Met Lys Gly Asp Pro Lys Glu Ile Leu Ser 
            180                 185                 190         


Asn Ala Lys Val Pro Glu Arg Cys Ser Arg Leu Cys Lys Glu Phe Leu 
        195                 200                 205             


Arg Ile Phe Gly Glu Lys Lys Val Pro Glu Ile Ile Asp Glu Leu Ile 
    210                 215                 220                 


Arg Ile Phe Gly Thr Gln Lys Lys Glu Gly Glu Val Val Phe Phe Asp 
225                 230                 235                 240 


Ala Ile Pro Ile Ala Glu Glu Ile Ala Asp Lys Pro Ile Leu Glu Leu 
                245                 250                 255     


Asp Ile Met Asn Pro His Tyr Gly Pro Tyr Tyr Gln Ser Gly Glu Lys 
            260                 265                 270         


Asn Val Pro Pro Pro Gly Asp Trp Tyr Asp Pro Ile Pro Ile Phe Phe 
        275                 280                 285             


Leu Thr Val Pro Lys Asp Val Pro Phe Leu Val Ala Val Gly Gly Arg 
    290                 295                 300                 


Asp Arg Glu Leu Thr Glu Lys Ala Phe Ser Leu Val Lys Leu Ala Leu 
305                 310                 315                 320 


Arg Asp Leu Gly Val Gly Ala Lys Thr Ser Leu Gly Tyr Gly Arg Leu 
                325                 330                 335     


Val Glu Tyr Val 
            340 


<210>  58
<211>  169
<212>  PRT
<213>  Pyrococcus furiosus


<220>
<221>  PEPTIDE
<222>  (1)..(169)
<223>  type III-B CRISPR module-associated protein  Cmr5: 
       /protein_id=WP_011012265.1

<400>  58

Met Glu Val His Met Leu Ser Lys Asp Asn Lys Lys Ser Ile Arg Lys 
1               5                   10                  15      


Thr Leu Glu Gln Arg Arg Gly Glu Tyr Ala Tyr Tyr Val Ile Lys Glu 
            20                  25                  30          


Val Ala Asp Leu Asn Asp Lys Gln Leu Glu Glu Lys Tyr Ala Ser Leu 
        35                  40                  45              


Val Lys Lys Ala Pro Val Met Ile Leu Ser Asn Gly Leu Leu Gln Thr 
    50                  55                  60                  


Leu Ala Phe Leu Leu Ala Lys Ala Glu Thr Ser Pro Glu Lys Ala Asn 
65                  70                  75                  80  


Gln Ile Leu Ser Arg Val Asn Glu Tyr Pro Pro Arg Phe Ile Glu Lys 
                85                  90                  95      


Leu Gly Asn Asp Lys Asp Glu His Leu Leu Leu Tyr Leu His Ile Val 
            100                 105                 110         


Tyr Trp Leu Arg Glu Asn Val Asp Arg Asn Ile Asp Val Lys Thr Leu 
        115                 120                 125             


Leu Ser Gln Asp Tyr Ser Lys Val Leu Trp Ala Thr Lys Glu Ala Ile 
    130                 135                 140                 


Ala Leu Leu Asn Trp Met Arg Arg Phe Ala Val Ala Met Leu Lys Glu 
145                 150                 155                 160 


Glu Gly Lys Glu Asn Glu Gly Ser Ser 
                165                 


<210>  59
<211>  295
<212>  PRT
<213>  Pyrococcus furiosus


<220>
<221>  PEPTIDE
<222>  (1)..(295)
<223>  type III-B CRISPR module RAMP protein Cmr4: 
       /protein_id=WP_011012266.1

<400>  59

Met Lys Ala Tyr Leu Val Gly Leu Tyr Thr Leu Thr Pro Thr His Pro 
1               5                   10                  15      


Gly Ser Gly Thr Glu Leu Gly Val Val Asp Gln Pro Ile Gln Arg Glu 
            20                  25                  30          


Arg His Thr Gly Phe Pro Val Ile Trp Gly Gln Ser Leu Lys Gly Val 
        35                  40                  45              


Leu Arg Ser Tyr Leu Lys Leu Val Glu Lys Val Asp Glu Glu Lys Ile 
    50                  55                  60                  


Asn Lys Ile Phe Gly Pro Pro Thr Glu Lys Ala His Glu Gln Ala Gly 
65                  70                  75                  80  


Leu Ile Ser Val Gly Asp Ala Lys Ile Leu Phe Phe Pro Val Arg Ser 
                85                  90                  95      


Leu Lys Gly Val Tyr Ala Tyr Val Thr Ser Pro Leu Val Leu Asn Arg 
            100                 105                 110         


Phe Lys Arg Asp Leu Glu Leu Ala Gly Val Lys Asn Phe Gln Thr Glu 
        115                 120                 125             


Ile Pro Glu Leu Thr Asp Thr Ala Ile Ala Ser Glu Glu Ile Thr Val 
    130                 135                 140                 


Asp Asn Lys Val Ile Leu Glu Glu Phe Ala Ile Leu Ile Gln Lys Asp 
145                 150                 155                 160 


Asp Lys Gly Ile Leu Glu Ser Val Val Lys Ala Ile Glu Gln Ala Phe 
                165                 170                 175     


Gly Asn Glu Met Ala Glu Lys Ile Lys Gly Arg Ile Ala Ile Ile Pro 
            180                 185                 190         


Asp Asp Val Phe Arg Asp Leu Val Glu Leu Ser Thr Glu Ile Val Ala 
        195                 200                 205             


Arg Ile Arg Ile Asn Ala Glu Thr Gly Thr Val Glu Thr Gly Gly Leu 
    210                 215                 220                 


Trp Tyr Glu Glu Tyr Ile Pro Ser Asp Thr Leu Phe Tyr Ser Leu Ile 
225                 230                 235                 240 


Leu Val Thr Pro Arg Ala Lys Asp Asn Asp Met Ala Leu Ile Lys Glu 
                245                 250                 255     


Val Leu Gly Lys Ile Asn Gly Lys Tyr Leu Gln Ile Gly Gly Asn Glu 
            260                 265                 270         


Thr Val Gly Lys Gly Phe Val Lys Val Thr Leu Lys Glu Val Thr Asn 
        275                 280                 285             


Asn Gly Gly Thr His Ala Lys 
    290                 295 


<210>  60
<211>  480
<212>  PRT
<213>  Pyrococcus furiosus


<220>
<221>  PEPTIDE
<222>  (1)..(480)
<223>  TIGR01897 family CRISPR-associated protein: 
       /protein_id=WP_011012267.1

<400>  60

Met Gly Met Arg Val Leu Val Thr Thr Trp Gly Asn Pro Phe Gln Trp 
1               5                   10                  15      


Glu Pro Ile Thr Tyr Glu Tyr Arg Gly Ile Lys Val Lys Ser Arg Asn 
            20                  25                  30          


Thr Leu Pro Ile Leu Val Lys Thr Leu Glu Pro Glu Arg Ile Leu Ile 
        35                  40                  45              


Leu Val Ala Asp Thr Met Ala Asn Tyr Tyr Asp Ser Gly Lys Asn Lys 
    50                  55                  60                  


Pro Glu Ile Glu Glu Lys Ser Phe Ser Ser Tyr Ser Glu Val Val Glu 
65                  70                  75                  80  


Asp Thr Lys Glu Arg Ile Leu Trp His Ile Lys Glu Glu Val Ile Glu 
                85                  90                  95      


Glu Leu Arg Glu Glu Asp Pro Glu Leu Ala Lys Lys Ile Glu Asn Met 
            100                 105                 110         


Leu Lys Asp Glu Arg Ile Thr Ile Glu Val Leu Pro Gly Val Gly Val 
        115                 120                 125             


Phe Gly Asn Ile Thr Val Glu Gly Glu Met Leu Asp Phe Tyr Tyr Tyr 
    130                 135                 140                 


Ala Thr Tyr Lys Leu Ala Glu Trp Leu Pro Val Gln Asn Asn Leu Glu 
145                 150                 155                 160 


Val Tyr Leu Asp Leu Thr His Gly Ile Asn Phe Met Pro Thr Phe Thr 
                165                 170                 175     


Tyr Arg Ala Leu Arg Asn Leu Leu Gly Leu Leu Ala Tyr Leu Tyr Asn 
            180                 185                 190         


Val Lys Phe Glu Ile Val Asn Ser Glu Pro Tyr Pro Leu Gly Val Ser 
        195                 200                 205             


Gln Glu Ile Arg Glu Asp Thr Ile Leu His Ile Arg Glu Ile Gly Glu 
    210                 215                 220                 


Gly Val Val Arg Pro Arg Pro Gln Tyr Ser Pro Val Glu Gly Lys Leu 
225                 230                 235                 240 


Tyr Trp Asn Ala Phe Ile Ser Ser Val Ala Asn Gly Phe Pro Leu Val 
                245                 250                 255     


Phe Ala Ser Phe Tyr Pro Asn Ile Arg Asp Val Glu Asp Tyr Leu Asn 
            260                 265                 270         


Lys Lys Leu Glu Glu Phe Leu Val Gly Ile Glu Val Gly Glu Arg Glu 
        275                 280                 285             


Asp Gly Lys Pro Tyr Val Lys Arg Glu Lys Ala Leu Asp Arg Ser Phe 
    290                 295                 300                 


Lys Asn Ala Ser Lys Leu Tyr Tyr Ala Leu Arg Val Phe Asn Thr Lys 
305                 310                 315                 320 


Phe Gln Asn Tyr Pro Lys Lys Glu Val Pro Ile Glu Glu Ile Met Glu 
                325                 330                 335     


Ile Ser Lys Ile Phe Glu Ser Leu Pro Arg Ile Gly Ile Ile Leu Glu 
            340                 345                 350         


Arg Gln Val Glu Trp Leu Arg Asn Leu Val Tyr Gly Arg Leu Trp Tyr 
        355                 360                 365             


Glu Asn Gly Glu Gln Lys Ile Lys Lys Gly Leu Leu Glu Ile Ile Lys 
    370                 375                 380                 


Asp Lys Lys Asp Lys Arg Lys Glu Ala Glu Ala Leu Lys Lys Gly Lys 
385                 390                 395                 400 


Thr Ile Ser Leu Ala Glu Ala Ala Lys Leu Thr Arg Ile Phe Ser Pro 
                405                 410                 415     


Ser Gly Glu Arg Ile Glu Thr Ile Glu Ser Pro Asn Val Val Arg Asn 
            420                 425                 430         


Phe Ile Ala His Ser Gly Phe Glu Tyr Asn Ile Val Tyr Val Lys Tyr 
        435                 440                 445             


Asp Arg Leu Ser Asp Arg Leu Tyr Phe Phe Tyr Lys Asp Lys Glu Lys 
    450                 455                 460                 


Ala Ala Asn Leu Ala Tyr Glu Ala Leu Leu Tyr Arg Gly Glu Lys Glu 
465                 470                 475                 480 


<210>  61
<211>  322
<212>  PRT
<213>  Pyrococcus furiosus


<220>
<221>  PEPTIDE
<222>  (1)..(322)
<223>  type III-B CRISPR module-associated protein Cmr3: 
       /protein_id=WP_011012268.1

<400>  61

Met Ile Glu Val Thr Phe Thr Pro Tyr Asp Val Leu Leu Phe Arg Glu 
1               5                   10                  15      


Ser Arg Pro Phe Asp Ala Gly Ser Glu Ser Val Ala Arg Ser Ile Ile 
            20                  25                  30          


Pro Leu Pro Gln Thr Val Ala Gly Ala Ile Arg Thr Leu Leu Phe Tyr 
        35                  40                  45              


Lys Gly Leu Lys Asn Cys Val Gly Val Gly Glu Glu Glu Pro Glu Phe 
    50                  55                  60                  


Thr Leu Val Gly Ile Ala Ile Gly Thr Glu Lys Gly Arg Ile Tyr Pro 
65                  70                  75                  80  


Leu Pro Phe Asn Ile Ile Lys Ser Glu Lys Phe Tyr Lys Val Val Asn 
                85                  90                  95      


Pro Gly Arg Phe Leu Gly Lys Leu Ile Leu Pro Pro Lys Gly Lys Tyr 
            100                 105                 110         


Lys Ser Gly Tyr Val Thr Glu Ser Ile Leu Glu Lys Tyr Leu Lys Gly 
        115                 120                 125             


Glu Leu Lys Glu Val Glu Glu Asn Lys Val Ile Arg Ile Glu Lys Glu 
    130                 135                 140                 


Lys Arg Ile Gly Ile Lys Leu Ser Arg Glu Lys Lys Val Val Glu Glu 
145                 150                 155                 160 


Gly Met Leu Tyr Thr Val Glu Phe Leu Arg Ile Glu Lys Ile Tyr Ala 
                165                 170                 175     


Trp Ile Glu Asp Pro Gly Cys Gly Ile Lys Asp Ile Leu Ser Ser Tyr 
            180                 185                 190         


Glu Phe Leu Thr Leu Gly Gly Glu Ser Arg Val Ala Phe Val Glu Val 
        195                 200                 205             


Asp Asp Lys Thr Pro Asp Ile Phe Asn Arg Glu Leu Gly Ser Thr Lys 
    210                 215                 220                 


Lys Ala Leu Phe Tyr Phe Ser Thr Pro Thr Ile Gly Lys Val Gly Glu 
225                 230                 235                 240 


Ile Val Gln Glu Leu Glu Lys Arg Leu Asn Ala Lys Ile Asp Asp Tyr 
                245                 250                 255     


Leu Leu Val Ser Ser Arg Pro Thr Ala Ile Ser Gly Trp Asp Met His 
            260                 265                 270         


Glu Lys Lys Pro Lys Gly Thr Lys Phe Ala Ile Pro Pro Gly Ser Val 
        275                 280                 285             


Leu Phe Val Glu Phe Lys Glu Glu Val Glu Val Pro Pro Tyr Ile Lys 
    290                 295                 300                 


Leu Gly Lys Leu Lys Lys Leu Gly Tyr Gly Leu Ala Leu Gly Gly Ile 
305                 310                 315                 320 


Trp Glu 
        


<210>  62
<211>  871
<212>  PRT
<213>  Pyrococcus furiosus


<220>
<221>  PEPTIDE
<222>  (1)..(871)
<223>  type III-B CRISPR-associated protein 
       Cas10/Cmr2:/protein_id=WP_011012269.1

<400>  62

Met Val Asn Ile Lys Glu Lys Leu Phe Val Tyr Leu His Asp Pro Pro 
1               5                   10                  15      


Asp Lys Ala Leu Lys Ile Glu Asn His Glu Glu Arg Ser Lys Lys Ile 
            20                  25                  30          


Leu Ser Ser Gly Asn Ile Gln Tyr Ser Arg Thr Asp Lys Val Lys Gln 
        35                  40                  45              


Ala Asp Ala Leu Ser Ser Lys Thr Gln Arg Phe Ile Ile Arg Thr Lys 
    50                  55                  60                  


Glu Asn Lys Glu Pro Val Ile Asp Phe Leu Gly Arg Ser Ser Gly Lys 
65                  70                  75                  80  


Tyr Phe His Val Gly Tyr Pro Val Phe Ile His Pro Ile Ser Thr Glu 
                85                  90                  95      


Ile Lys Arg Tyr Glu Thr Leu Glu Lys Tyr Ile Asp Leu Gly Arg Ser 
            100                 105                 110         


Asn Arg Gly Glu Arg Phe Val Asn Glu Phe Leu Glu Arg Val Ser Lys 
        115                 120                 125             


Leu Glu Gly Asp Val Leu Lys Glu Val Phe Glu Asp Ala Ser Asn Lys 
    130                 135                 140                 


Phe Lys Gly Glu Glu Ser Lys Gln Trp Ala Tyr Ile Trp Gln Phe Tyr 
145                 150                 155                 160 


Pro Val Lys Leu Lys Glu Gly Val Lys Glu Phe Ala Lys Ser Glu Leu 
                165                 170                 175     


Lys Leu Lys Glu Glu Glu Ala Glu Lys Phe Ala Glu Glu Phe Val Asn 
            180                 185                 190         


Leu Pro Ala Asp Thr Arg Phe Pro Asp His Ala Ile Trp Thr His Leu 
        195                 200                 205             


Asp Leu Thr Ser Ala Leu Ser Val Lys Asp Pro Thr Leu Leu Arg Ile 
    210                 215                 220                 


Lys Ile Val Pro Val Gln Pro Phe Ile Ala Asn Ser Arg Lys Gln Leu 
225                 230                 235                 240 


Asp Leu Trp Ala Ser Ser His Leu Leu Ser Met Leu Met Tyr Lys Ala 
                245                 250                 255     


Leu Glu Val Ile Val Asp Lys Phe Gly Pro Glu His Val Ile Tyr Pro 
            260                 265                 270         


Ser Leu Arg Asp Gln Pro Phe Phe Leu Lys Phe Tyr Leu Gly Glu Asn 
        275                 280                 285             


Ile Gly Asp Glu Ile Leu Val Ala Asn Leu Pro Asn Lys Ala Leu Ala 
    290                 295                 300                 


Ile Val Ser Gly Lys Glu Ala Glu Lys Ile Glu Glu Glu Ile Lys Lys 
305                 310                 315                 320 


Arg Ile Arg Asp Phe Leu Leu Gln Leu Tyr Arg Glu Ala Val Asp Trp 
                325                 330                 335     


Ala Val Glu Asn Gly Val Val Lys Val Asp Arg Ser Glu Lys Asp Ser 
            340                 345                 350         


Met Leu Lys Glu Ala Tyr Leu Lys Ile Val Arg Glu Tyr Phe Thr Val 
        355                 360                 365             


Ser Ile Thr Trp Val Ser Leu Ser Glu Lys Glu Asp Ile Tyr Gln Val 
    370                 375                 380                 


Thr Glu Asn Ala Gly Leu Ser Asp Glu Asp Val Lys Lys Trp Leu Lys 
385                 390                 395                 400 


Phe Ala Glu Lys Lys Glu Asn Ser Arg Val Leu Glu Arg Ile Ala Ile 
                405                 410                 415     


Tyr Pro Leu Leu Val Lys Ile Leu Asp Ser Leu Gly Glu Arg Lys Val 
            420                 425                 430         


Thr Glu Glu Arg Phe Glu Lys Ser Glu Gln Leu Lys Gly Trp Lys Cys 
        435                 440                 445             


His Val Cys Gly Glu Asn Leu Ala Ile Phe Gly Asp Met Tyr Asp His 
    450                 455                 460                 


Asp Asn Leu Lys Ser Leu Trp Leu Asp Glu Glu Pro Leu Cys Pro Met 
465                 470                 475                 480 


Cys Leu Ile Lys Arg Tyr Tyr Pro Val Trp Ile Arg Ser Lys Thr Gly 
                485                 490                 495     


Gln Lys Ile Arg Phe Glu Ser Val Val Asp Val Ala Leu Leu Tyr Lys 
            500                 505                 510         


Asn Trp Arg Lys Ile Phe Asp Glu Lys Tyr Gly Lys Asp Leu Val Ser 
        515                 520                 525             


Lys Ala Arg Glu Val Ser Glu Asp Phe Val Lys Asp Asn Met Leu Val 
    530                 535                 540                 


Asp Ser Asp Leu Tyr Tyr Ser Ser Thr Trp Glu Ser Gly Leu Ser Lys 
545                 550                 555                 560 


Lys Leu Lys Asn Lys Lys Glu Ile Asp Glu Glu Lys Val Lys Glu Val 
                565                 570                 575     


Val Asp Phe Leu Asn Ala Ala Tyr Lys Glu Ile Gly Asn Pro Pro Lys 
            580                 585                 590         


Tyr Tyr Ala Ile Leu Val Met Asp Gly Asp Asp Met Gly Lys Val Ile 
        595                 600                 605             


Ser Gly Glu Val Leu Gly Glu Ile Ser Thr Arg Ile His Pro Asn Ile 
    610                 615                 620                 


Arg Asp Tyr Val Glu Ile Pro Glu Ala Lys Tyr Tyr Ser Thr Pro Gln 
625                 630                 635                 640 


Val His Val Ala Ile Ser Gln Ala Leu Ala Asn Phe Ser Ile Arg Glu 
                645                 650                 655     


Val Arg Ser Val Val Lys Asp Glu Gly Leu Leu Ile Tyr Ala Gly Gly 
            660                 665                 670         


Asp Asp Val Leu Ala Ile Leu Pro Val Asp Lys Ala Leu Glu Val Ala 
        675                 680                 685             


Tyr Lys Ile Arg Lys Glu Phe Gly Lys Ser Phe Glu Asn Gly Ser Leu 
    690                 695                 700                 


Leu Pro Gly Trp Lys Leu Ser Ala Gly Ile Leu Ile Val His Tyr Lys 
705                 710                 715                 720 


His Pro Leu Tyr Asp Ala Leu Glu Lys Ala Arg Asp Leu Leu Asn Asn 
                725                 730                 735     


Lys Ala Lys Asn Val Pro Gly Lys Asp Thr Leu Ala Ile Gly Leu Leu 
            740                 745                 750         


Lys Arg Ser Gly Ser Tyr Tyr Ile Ser Leu Val Gly Trp Glu Leu Ile 
        755                 760                 765             


Arg Val Phe Tyr Asn Ser Glu Leu Arg Lys Lys Leu Leu Glu Glu Lys 
    770                 775                 780                 


Gly Gly Val Gly Lys Arg Phe Ile Tyr His Val Leu Arg Glu Val Asp 
785                 790                 795                 800 


Thr Trp Pro Lys Val Gly Ile Asp Glu Met Leu Lys Phe Glu Val Ile 
                805                 810                 815     


Arg His Ile Arg Gly Arg Asn Lys Glu Glu Thr Lys Glu Leu Arg Glu 
            820                 825                 830         


Lys Ile Tyr Gly Glu Ile Lys Asp Leu Leu Glu His Val Arg Gly Asn 
        835                 840                 845             


Asn Glu Val Glu Lys Val Arg Gly Leu Phe Thr Phe Leu Lys Ile Ile 
    850                 855                 860                 


Thr Asp Ala Glu Val Phe Pro 
865                 870     


<210>  63
<211>  338
<212>  PRT
<213>  Pyrococcus furiosus


<220>
<221>  PEPTIDE
<222>  (1)..(338)
<223>  type III-B CRISPR module RAMP protein Cmr1:  
       /protein_id=WP_011012270.1

<400>  63

Met Phe Ile Glu Glu Phe Glu Ile Glu Ser Ile Thr Ser Thr His Leu 
1               5                   10                  15      


Leu Glu Val Leu Thr Arg Glu Tyr Pro Glu Val Arg Ser Pro Ser Ile 
            20                  25                  30          


Lys Gly Ala Met Arg Trp Trp Phe Arg Ala Leu Ala Gly Ser Tyr Phe 
        35                  40                  45              


Gly Asp Asp Ala Gln Lys Leu Lys Glu Ile Glu Asn Gln Val Phe Gly 
    50                  55                  60                  


Ser Thr Lys Glu Arg Ser Arg Val Lys Ile Ser Val Thr Pro Leu Ser 
65                  70                  75                  80  


Ser Pro Lys Arg Leu Asn Leu Lys Glu Phe Lys Asp Lys Asn Val Gly 
                85                  90                  95      


Tyr Ile Trp Phe Ser Ile Asn Leu Leu Gly Lys Arg Gly Thr Ile Thr 
            100                 105                 110         


His Tyr Tyr Pro Pro Gly Ser Arg Phe Arg Val Val Leu Glu Ser Pro 
        115                 120                 125             


Ser Glu Arg Val Ile Lys Leu Ala Thr Leu Ser Leu Trp Ala Leu Val 
    130                 135                 140                 


Ser Leu Gly Ser Val Gly Phe Arg Ser Arg Arg Gly Thr Gly Ser Met 
145                 150                 155                 160 


Lys Ile Val Arg Ala Ser Ser Glu Val Leu Glu Asp Leu Gly Leu Thr 
                165                 170                 175     


Thr Glu Phe Asn Ser Ile Asp Glu Phe Lys Asp Ser Leu Lys Arg Val 
            180                 185                 190         


Leu Asp Val Thr Gly Glu Ile Leu Gly Val Lys Asn Ser Glu Thr Asn 
        195                 200                 205             


Lys Ser Leu Pro Ser Tyr Ala Thr Leu Lys Phe Ser Asp Val Glu Val 
    210                 215                 220                 


Phe Gly Pro Gly Lys Asn Thr Trp Glu Val Leu Ala Gln Phe Asn Asn 
225                 230                 235                 240 


Ser Tyr Lys Glu Tyr Leu Arg Arg Arg Ile Lys Lys Tyr Gln Arg Ile 
                245                 250                 255     


Ile Phe Gly Leu Pro Arg Phe Lys Leu Arg Gly Val Arg Lys Asp Leu 
            260                 265                 270         


Arg Arg Ala Ser Pro Leu Trp Phe Gly Val Val Glu Ile Gly Gly Lys 
        275                 280                 285             


Pro Tyr Gly Arg Ile Ile Lys Phe Phe Gln Ser Thr Phe His Pro Glu 
    290                 295                 300                 


Val Arg Ser Lys His Ile Val Asp Trp Asn Val Leu Ser Asn Phe Asp 
305                 310                 315                 320 


Trp Phe Ile Ser Ser Arg Leu Pro Val Thr Lys Val Trp Gly Gly Trp 
                325                 330                 335     


Ser Gly 
        


<210>  64
<211>  264
<212>  PRT
<213>  Pyrococcus furiosus


<220>
<221>  PEPTIDE
<222>  (1)..(264)
<223>  CRISPR-associated endoribonuclease Cas6 
       /protein_id=WP_011012271.1

<400>  64

Met Arg Phe Leu Ile Arg Leu Val Pro Glu Asp Lys Asp Arg Ala Phe 
1               5                   10                  15      


Lys Val Pro Tyr Asn His Gln Tyr Tyr Leu Gln Gly Leu Ile Tyr Asn 
            20                  25                  30          


Ala Ile Lys Ser Ser Asn Pro Lys Leu Ala Thr Tyr Leu His Glu Val 
        35                  40                  45              


Lys Gly Pro Lys Leu Phe Thr Tyr Ser Leu Phe Met Ala Glu Lys Arg 
    50                  55                  60                  


Glu His Pro Lys Gly Leu Pro Tyr Phe Leu Gly Tyr Lys Lys Gly Phe 
65                  70                  75                  80  


Phe Tyr Phe Ser Thr Cys Val Pro Glu Ile Ala Glu Ala Leu Val Asn 
                85                  90                  95      


Gly Leu Leu Met Asn Pro Glu Val Arg Leu Trp Asp Glu Arg Phe Tyr 
            100                 105                 110         


Leu His Glu Ile Lys Val Leu Arg Glu Pro Lys Lys Phe Asn Gly Ser 
        115                 120                 125             


Thr Phe Val Thr Leu Ser Pro Ile Ala Val Thr Val Val Arg Lys Gly 
    130                 135                 140                 


Lys Ser Tyr Asp Val Pro Pro Met Glu Lys Glu Phe Tyr Ser Ile Ile 
145                 150                 155                 160 


Lys Asp Asp Leu Gln Asp Lys Tyr Val Met Ala Tyr Gly Asp Lys Pro 
                165                 170                 175     


Pro Ser Glu Phe Glu Met Glu Val Leu Ile Ala Lys Pro Lys Arg Phe 
            180                 185                 190         


Arg Ile Lys Pro Gly Ile Tyr Gln Thr Ala Trp His Leu Val Phe Arg 
        195                 200                 205             


Ala Tyr Gly Asn Asp Asp Leu Leu Lys Val Gly Tyr Glu Val Gly Phe 
    210                 215                 220                 


Gly Glu Lys Asn Ser Leu Gly Phe Gly Met Val Lys Val Glu Gly Asn 
225                 230                 235                 240 


Lys Thr Thr Lys Glu Ala Glu Glu Gln Glu Lys Ile Thr Phe Asn Ser 
                245                 250                 255     


Arg Glu Glu Leu Lys Thr Gly Val 
            260                 


<210>  65
<211>  92
<212>  PRT
<213>  Marinomonas mediterranea


<220>
<221>  misc_feature
<223>  CRISPR-associated endonuclease Cas2:  /protein_id=WP_013659857.1

<400>  65

Met Arg Ile Tyr Leu Ala Cys Phe Asp Ile Glu Asp Asp Lys Lys Arg 
1               5                   10                  15      


Arg Lys Leu Ser Asn Leu Leu Leu Glu Tyr Gly Asp Arg Val Gln Tyr 
            20                  25                  30          


Ser Val Phe Glu Ile Ser Leu Lys Asp Glu Asn Glu Leu His Lys Leu 
        35                  40                  45              


Arg Lys Lys Cys Ser Lys Tyr Thr Glu Glu Ala Asp Ser Leu Arg Phe 
    50                  55                  60                  


Tyr Trp Leu Asn Lys Glu Ser Arg Lys His Ser Gln Asp Val Trp Gly 
65                  70                  75                  80  


Asn Pro Ile Ala Val Phe Pro Ala Ala Val Leu Leu 
                85                  90          


<210>  66
<211>  957
<212>  PRT
<213>  Marinomonas mediterranea


<220>
<221>  PEPTIDE
<222>  (1)..(957)
<223>  CRISPR-associated endonuclease Cas1: /protein_id=WP_013659858.1

<400>  66

Met Leu Asn Ser Pro Leu Ile Asp Ala Val Leu Pro Leu Arg Ser Val 
1               5                   10                  15      


Val Ile Thr Leu Arg Trp Leu Ser Pro Ser Lys Thr Gly Phe Leu His 
            20                  25                  30          


His Ala Gly Leu His Ala Trp Val Arg Phe Leu Ala Gly Ser Pro Glu 
        35                  40                  45              


Gln Phe Ser Asp Phe Ile Val Val Glu Pro Ile Glu Asn Gly His Ile 
    50                  55                  60                  


Ser Tyr Gln Ala Gly Asp Gly Tyr Arg Phe Arg Ile Thr Val Leu Asn 
65                  70                  75                  80  


Gly Gly Glu Ser Leu Leu Asp Thr Leu Phe Ser Ser Leu Lys Arg Leu 
                85                  90                  95      


Pro Glu Ser Ala Ala Asn His Pro Asp Ile Ala Gly Ala Phe Ser Asp 
            100                 105                 110         


Asn Leu Val Leu Glu Lys Ile Glu Asp Thr Phe Glu His His Gln Val 
        115                 120                 125             


Thr Gln Ile Glu Asp Leu Ser Val Phe Asp Ile Asn Ala Leu Met Leu 
    130                 135                 140                 


Glu Thr Ala Val Trp Ser Arg Gln Arg Arg Phe Lys Val Ala Phe Asn 
145                 150                 155                 160 


Thr Pro Ala Arg Leu Val Lys Pro Lys Pro Glu Asp Gly Thr Glu Leu 
                165                 170                 175     


Lys Gly Gln Asn Arg Tyr Cys Arg Asp Lys Ser Asp Leu Asn Trp Gln 
            180                 185                 190         


Leu Phe Thr His Arg Leu Thr Asp Thr Phe Ile Asn Leu Phe Gln Ser 
        195                 200                 205             


Arg Thr Gly Glu Arg Leu Gln Arg Gln Asn Trp Pro Glu Ala Gln Leu 
    210                 215                 220                 


His Ala Gly Leu Ala Val Trp Leu Asn Asn Ser Tyr Thr Asn Lys Lys 
225                 230                 235                 240 


Glu Lys Lys Val Lys Asp Ala Ser Gly Met Leu Ala Gln Met Gln Ile 
                245                 250                 255     


Glu Ile Asp Asp Asp Phe Pro Ala Asp Leu Leu Ala Leu Leu Val Leu 
            260                 265                 270         


Gly Gln Tyr Ile Gly Met Gly Gln Asn Arg Ala Phe Gly Met Gly Gln 
        275                 280                 285             


Tyr Gln Leu Gln Asp Ala Tyr Gly Tyr Cys Ser Tyr Pro Arg Pro Gln 
    290                 295                 300                 


Ala Ala Lys Ser Leu Leu Glu Lys Ser Leu Ser Asp Ala Ser Leu His 
305                 310                 315                 320 


Gln Ala Cys Gln Thr Met Tyr Pro Arg Gln Ala Asn Phe Asp Ser Ser 
                325                 330                 335     


Asp Thr Asp Glu Glu His His Asp Ala Ile Asp Glu Leu Leu Thr Lys 
            340                 345                 350         


Leu Tyr Val Ser Arg Glu Arg Ile Phe Lys Arg Glu Phe Thr Pro Ser 
        355                 360                 365             


Gln Leu His Ser Val Glu Ile Glu Lys Pro Glu Gly Gly Thr Arg Leu 
    370                 375                 380                 


Leu Ser Val Pro Asn Trp His Asp Arg Thr Leu Gln Lys Ala Val Thr 
385                 390                 395                 400 


Glu Cys Leu Gly Asn Thr Leu Glu His Ile Trp Met Lys His Ser Tyr 
                405                 410                 415     


Gly Tyr Arg Lys Gly His Ser Arg Leu Gln Ala Arg Asp Gln Ile Asn 
            420                 425                 430         


Gln Tyr Ile Gln Gln Gly Tyr Glu Trp Val Leu Glu Ser Asp Ile Glu 
        435                 440                 445             


Ser Phe Phe Asp Ser Val Asn Trp Leu Asn Leu Glu Gln Arg Leu Lys 
    450                 455                 460                 


Leu Leu Leu Pro Asn Glu Pro Leu Val Pro Leu Leu Met Gln Trp Val 
465                 470                 475                 480 


Ser Ala Ala Lys Gln Thr Glu Asp Glu Gln Thr Leu Ala Arg His Asn 
                485                 490                 495     


Gly Leu Pro Gln Gly Ala Pro Ile Ser Pro Ile Leu Ala Asn Leu Leu 
            500                 505                 510         


Leu Asp Asp Leu Asp Gln Asp Met Ile Ala Lys Gly His Gln Ile Val 
        515                 520                 525             


Arg Tyr Ala Asp Asp Phe Val Leu Leu Phe Lys Ser Lys Ala Ala Ala 
    530                 535                 540                 


Glu Ser Ala Leu Asp Asp Ile Ile Thr Ala Leu Lys Glu His His Leu 
545                 550                 555                 560 


Ala Ile Asn Leu Glu Lys Thr Arg Ile Val Glu Ala Ser Gln Gly Phe 
                565                 570                 575     


Arg Tyr Leu Gly Tyr Leu Phe Val Asp Gly Tyr Ala Ile Glu Thr Lys 
            580                 585                 590         


Arg Glu Tyr Arg Lys Glu His Ala Gln Leu Asp Lys Gln Leu Asn Ala 
        595                 600                 605             


Ser Ser Leu Glu Asn Glu Pro Ser Leu Gln Gln Glu Pro Ala Val Gln 
    610                 615                 620                 


Asn Glu Gln Ser Thr Leu Ile Gly Glu Arg Glu Lys Leu Gly Thr Leu 
625                 630                 635                 640 


Leu Ile Ile Ala Gly Asp Ile Ala Met Leu Ser Ser Glu Lys Gln Arg 
                645                 650                 655     


Leu Ile Val Glu Gln Tyr Asp Glu Leu His Thr Tyr Pro Trp Ala Thr 
            660                 665                 670         


Leu Ser Ser Val Leu Leu Val Gly Pro His His Ile Thr Thr Pro Ala 
        675                 680                 685             


Leu Lys Ser Ala Met Phe His Asn Val Pro Val His Phe Ala Ser Gln 
    690                 695                 700                 


Tyr Gly Arg Tyr Gln Gly Val Ser Ala Gly Ala Ala Pro Ser Val Phe 
705                 710                 715                 720 


Gly Ala Asp Phe Trp Leu Leu Gln Ala Gln Tyr Leu Gln Gln Glu Thr 
                725                 730                 735     


Asn Ala Leu Asn Ile Ser Gln Val Leu Ile Gln Ala Arg Ile Glu Gly 
            740                 745                 750         


Ile Arg Ala Val Ile Ser Arg Arg Glu Lys Asp Ala Pro Glu Leu Asn 
        755                 760                 765             


Lys Ile Gln Arg Leu Asp Glu Lys Arg Leu Arg Ala Glu Thr Leu Asp 
    770                 775                 780                 


Gln Leu Arg Gly Tyr Glu Gly Gln Ala Ser Lys Gln Leu Trp Ala Phe 
785                 790                 795                 800 


Phe Gln Arg Ile Leu Glu Glu Asp Trp Gly Phe Thr Gly Arg Asn Arg 
                805                 810                 815     


Arg Pro Pro Lys Asp Pro Ile Asn Ala Leu Leu Ser Leu Gly Tyr Thr 
            820                 825                 830         


Tyr Leu Tyr Ser Leu Val Asp Ser Val Asn Arg Thr Val Gly Leu Tyr 
        835                 840                 845             


Pro Trp Gln Gly Ala Leu His Gln Arg His Gly Tyr His His Thr Leu 
    850                 855                 860                 


Ala Ser Asp Leu Met Glu Pro Trp Arg Tyr Leu Val Glu His Val Val 
865                 870                 875                 880 


Leu Thr Leu Ile Asn Arg His Gln Ile His Lys Asp Asp Phe Val Ile 
                885                 890                 895     


Lys Glu Asn Gly Cys Glu Met Ser Ser Gly Ala Arg Lys Thr Leu Leu 
            900                 905                 910         


Lys Glu Leu Leu Val Gln Leu Thr Lys Val Pro Lys Gly Gly Asn Ser 
        915                 920                 925             


Leu Leu Thr Glu Met Ser Asn Gln Ser Tyr Arg Leu Ala Leu Ser Cys 
    930                 935                 940                 


Lys Met Gln Gln Arg Phe Ile Ala Trp Ser Pro Lys Arg 
945                 950                 955         


<210>  67
<211>  256
<212>  PRT
<213>  Marinomonas mediterranea


<220>
<221>  PEPTIDE
<222>  (1)..(256)
<223>  hypothetical protein /protein_id="WP_013659859.1"

<400>  67

Met Asn Asn Ala Lys Thr Lys Ser Asp Thr Asp Gly Glu Gln Tyr Leu 
1               5                   10                  15      


Lys Asp Ser Phe Gln Arg Glu Gln Glu Leu Leu Glu Ser Lys Leu Leu 
            20                  25                  30          


Phe Ala Asn Gln Asn Ile Thr His Asn Gly Glu Arg Gly Glu Val Asn 
        35                  40                  45              


Glu Lys His Phe Ile Glu Tyr Leu Arg Ser His Leu Pro Lys Arg Tyr 
    50                  55                  60                  


Ser Val Asp Ser Ala Ile Val Val Asp Ser Asn Gly Lys Thr Ser Asn 
65                  70                  75                  80  


Gln Ile Asp Ile Val Val Tyr Asp Asn Gln Tyr Thr Pro Thr Leu Phe 
                85                  90                  95      


Ala Gln Gln Asp Phe Cys Tyr Val Pro Ala Glu Ala Val Tyr Ala Val 
            100                 105                 110         


Ile Glu Val Lys Pro Glu Val Asn Arg Asp Tyr Ile Glu Tyr Ala Gln 
        115                 120                 125             


Lys Gln Ala Tyr Ser Val Glu Ala Leu Glu Arg Thr Ser Ile Glu Ile 
    130                 135                 140                 


Thr His Ala Gly Gly Val Tyr Lys Pro Lys Pro Leu Phe Lys Ile Ile 
145                 150                 155                 160 


Thr Gly Leu Ile Ala Leu Lys Thr Gly Trp Gln Glu Gly Leu Ala Ser 
                165                 170                 175     


Asn Ser Phe Lys Asp Ala Ile Gln Met Pro Tyr Thr Asn Gln Thr Arg 
            180                 185                 190         


Leu Asp Phe Val Thr Ser Leu Gln Gly Gly His Phe Asp Cys Phe Glu 
        195                 200                 205             


Lys Gly Asn Glu His Tyr Ser Gln Gln Asn His Leu Thr Phe Phe Leu 
    210                 215                 220                 


Phe Arg Leu Leu Ser Gln Leu Gln Ser Leu Gly Thr Val Pro Ala Val 
225                 230                 235                 240 


Asp Trp Asn Lys Tyr Ala Asn Val Leu Thr Glu Gln Ser Lys Pro Asp 
                245                 250                 255     


<210>  68
<211>  371
<212>  PRT
<213>  Marinomonas mediterranea


<220>
<221>  PEPTIDE
<222>  (1)..(371)
<223>  type III-B CRISPR module RAMP protein Cmr6 
       /protein_id=WP_013659861.1

<400>  68

Met Ser Ser Val Gln Leu Val Pro Gln Arg Leu Phe Asn Ile Tyr Glu 
1               5                   10                  15      


Met His Leu Lys Ser Arg Thr Ser Asn Gly Leu His Ser Gly Leu Leu 
            20                  25                  30          


Leu Asp Lys Gly Tyr Pro Ala Ser Ser Thr Gly Val Asn Thr Asp Lys 
        35                  40                  45              


Glu Ala Lys Ala Arg Phe Ile Lys Ser Ile Cys Gly Ile Lys Ala Ser 
    50                  55                  60                  


Glu Leu Tyr Thr Lys Glu Phe Asn Gln Trp Leu Arg Leu Thr Ser Lys 
65                  70                  75                  80  


Lys Ser Asn Ser Gly Lys His Thr Asn Asn Phe Glu Gln Leu Pro Leu 
                85                  90                  95      


Thr Leu Ser Asn Arg Leu Leu Ile Gly Leu Asn Gly Gly Gly Ala Leu 
            100                 105                 110         


Glu Thr Gly Cys Met Ile Asn His His Asn Gly Met Pro Tyr Ile Pro 
        115                 120                 125             


Gly Ser Ser Ile Lys Gly Ala Val Arg Asn Phe Ala Ser Arg Asn Leu 
    130                 135                 140                 


Lys Asp His Glu Ser Val Trp Val Gln Phe Phe Gly Asn Lys Pro Glu 
145                 150                 155                 160 


Asp Asp Leu Glu Asp Pro Phe Ala Gly Leu Ile Thr Phe His Asp Ala 
                165                 170                 175     


Trp Trp Ile Pro Asn Ser Ala Pro Ser Glu Asn Ala Gly Asn Phe Ser 
            180                 185                 190         


Asn Phe Pro Phe Ile Gln Asp Ile Val Thr Thr His His Ala Glu Tyr 
        195                 200                 205             


Tyr Ser Lys Glu Gly Lys Ser Leu Ala Thr Asp Phe Asp Asp Pro Ile 
    210                 215                 220                 


Pro Asn Ser Leu Ile Ser Val His Gly Ser Phe Leu Phe Val Ile Gly 
225                 230                 235                 240 


Gly Asn Glu Asn Tyr Leu Gly Val Val Lys Gln Met Leu Glu Lys Thr 
                245                 250                 255     


Leu Lys Glu Asn Gly Ile Gly Ala Lys Ser Thr Ala Gly Tyr Gly Tyr 
            260                 265                 270         


Phe Asp Glu Ala Asp Glu Ser Ile Thr Lys Gln Phe Ser Ile Leu Leu 
        275                 280                 285             


Ser Asp Thr Glu Asn Thr Asn Thr Thr Pro His Ser Ser Glu Leu Ile 
    290                 295                 300                 


Arg Glu Val Ser Glu Ile Lys Leu Ser Lys Ile Pro Asp Ile Phe Gly 
305                 310                 315                 320 


Arg Asn Arg Asn Lys Thr Lys Asn Glu Lys Gly Lys Asp Tyr Arg Ser 
                325                 330                 335     


Leu Cys Leu Leu Val Cys Lys His Phe Gly Asp Glu Ile Ala Asn Trp 
            340                 345                 350         


Ala Thr Glu Ser Gly Asn Lys Ala Lys Ala Tyr Lys Glu Leu Lys Glu 
        355                 360                 365             


Phe Leu Glu 
    370     


<210>  69
<211>  140
<212>  PRT
<213>  Marinomonas mediterranea


<220>
<221>  PEPTIDE
<222>  (1)..(140)
<223>  type III-B CRISPR module-associated protein Cmr5: 
       protein_id=WP_083799838.1

<400>  69

Met Ser Val Arg Gln His Lys Ile Ala Glu Ala Ala Tyr Asp Cys Val 
1               5                   10                  15      


Asn Lys Arg Ile Glu Glu Gly Ile Asp Gln Lys Lys Tyr Ala Ala Leu 
            20                  25                  30          


Ala Asn Lys Leu Pro Asn Leu Ile Leu Gln Asn Gly Leu Ala Gln Ala 
        35                  40                  45              


Thr Gly Phe Leu Met Ala Lys Asn Glu Ser Thr Asn Glu His Lys Lys 
    50                  55                  60                  


Leu Leu Asn Asp Leu Ala Phe Val Val Asn Ser Gly His Leu Glu Asn 
65                  70                  75                  80  


Gln Asn Thr Pro Asn Ser Asp Asn Gly Lys Glu Leu His Gln Gln Ile 
                85                  90                  95      


Ile Gln Ser Asp Met Thr Lys Phe Met Gln Leu Thr Gln Gln Ser Leu 
            100                 105                 110         


Asp Ala Ser Gly Ala Leu Arg Arg Tyr Val Gln Gly Leu Met Asp Thr 
        115                 120                 125             


Asn Lys Lys Asp Asp Asp Ser Gln Glu Glu Thr Leu 
    130                 135                 140 


<210>  70
<211>  300
<212>  PRT
<213>  Marinomonas mediterranea


<220>
<221>  PEPTIDE
<222>  (1)..(300)
<223>  type III-B CRISPR module RAMP protein Cmr4: 
       /protein_id=WP_013659863.1

<400>  70

Met Asp Leu Asn Ile Tyr His Leu His Thr His Ser Ala Leu His Cys 
1               5                   10                  15      


Gly Thr Gly Gln Ser Ala Gly Ile Val Asp Leu Pro Ile Ala Arg Asp 
            20                  25                  30          


Lys Ala Thr His Leu Pro Ile Val Pro Gly Ser Ser Leu Arg Gly Val 
        35                  40                  45              


Leu Arg Asp Lys Ile Arg Ala Asn Glu Lys Asp Ile Glu Lys Ala Leu 
    50                  55                  60                  


Phe Gly Pro Arg Asp Ile Gln Ser Ser Glu Gln Ser Phe Ala Gly Ala 
65                  70                  75                  80  


Leu Ser Leu Gly Asp Ala Asn Leu Leu Val Leu Pro Ile Arg Ser Leu 
                85                  90                  95      


Asn Gly Ile Val Ala Tyr Ala Thr Cys Pro Phe Val Leu Arg Asn Tyr 
            100                 105                 110         


Ala Asn Asp Thr Lys Ile Ser Val Lys Glu Thr Pro Leu Pro Gln Pro 
        115                 120                 125             


Ser Ala Gln Gln Ala Leu Val Ser Asn Glu Asn Val Asn Val Ile Gln 
    130                 135                 140                 


His Asp Asn His Thr Glu Leu Leu Val Leu Glu Asp Leu Asp Ile Ser 
145                 150                 155                 160 


Ala Glu Lys Asp Glu Lys Val Gln Ala Trp Ala Lys Lys Ile Ala Glu 
                165                 170                 175     


Ala Val Tyr Ser Glu Gln Ser Asp Leu Lys Asp Glu Phe Ile Asn Arg 
            180                 185                 190         


Phe Val Val Leu Ser Asp Asn Val Phe Ser Tyr Leu Ser Thr Thr Ala 
        195                 200                 205             


Thr Glu Leu Arg Thr Arg Ile Arg Ile Thr Glu Lys Thr Gly Val Val 
    210                 215                 220                 


Lys Glu Gly Ala Leu Trp Ser Glu Glu Asn Leu Pro Ala Asn Ala Ile 
225                 230                 235                 240 


Leu Trp Gly Val Tyr Ser Leu Ser Asp Ser Arg Asp Lys Lys Gln Glu 
                245                 250                 255     


Leu Thr Ala Pro Glu Leu Lys Glu Lys Leu Ser Ala Ser Tyr Thr Leu 
            260                 265                 270         


Gln Met Gly Gly Asn Ala Gly Ile Gly Arg Gly Leu Val Ser Leu Phe 
        275                 280                 285             


Thr Lys Lys Glu Glu Lys Glu Thr Gly Gly Gln Glu 
    290                 295                 300 


<210>  71
<211>  405
<212>  PRT
<213>  Marinomonas mediterranea


<220>
<221>  PEPTIDE
<222>  (1)..(405)
<223>  CRISPR-associated protein, Cmr3: protein_id=WP_013659864.1

<400>  71

Met His Thr His Asp Gln Lys Glu Asn Thr Tyr Leu Leu Asp Pro Lys 
1               5                   10                  15      


Ala Pro Leu Ile Ile Arg Ser Gly Arg Pro Phe Asp Glu Gln Ala Gly 
            20                  25                  30          


Ala Asp Asp Ala Arg Phe Pro Pro Pro Ser Thr Met Ala Gly Ala Leu 
        35                  40                  45              


Arg Ala Ala Tyr Ala Arg Ala Asn Asn Ile Gly Phe Asn Lys Glu Asn 
    50                  55                  60                  


Thr Gln Asp Ile Leu Ser Lys Ala Ile Lys Gly Pro Leu Pro Val Lys 
65                  70                  75                  80  


Gln Ser Thr Glu Glu Asp Ile Lys Thr Leu Leu Val Pro Lys Pro Glu 
                85                  90                  95      


Asp Ala Gln Tyr Tyr Tyr Asp Gln Ala Gly Asn Ile Glu Ile Val Arg 
            100                 105                 110         


Leu Ser Pro Arg Glu Leu Asp Glu Asn Glu Gly Trp Asp Leu Pro Arg 
        115                 120                 125             


Arg Leu Leu Pro Val Ser Tyr His Asp Asp Gln Glu Lys Arg His Gly 
    130                 135                 140                 


Lys Pro Ala Lys Gly Ala Gln Trp Trp Ser Leu Lys Asp Leu Leu Glu 
145                 150                 155                 160 


Trp Arg Leu His Lys Pro Ile Asn Tyr Lys Glu Val His Lys Asn Gly 
                165                 170                 175     


Trp Ile Pro Pro Ala Asp Asp Ile Arg Thr His Val Ala Ile Asn Pro 
            180                 185                 190         


Gln Ser Phe Ala Ala Glu Asp Gly Gln Leu Phe Gln Thr Ser Gly Leu 
        195                 200                 205             


Pro Met Trp Gln Val Lys Lys Glu Asn Gln Ser Ala Phe Pro Asp Glu 
    210                 215                 220                 


Lys Ile Leu Leu Ala Gly Cys Ile Asn Gly Asp Leu Phe Pro Glu Ala 
225                 230                 235                 240 


His Ser Lys Asn Asp Thr Pro Gln Ser Leu Asn Ile Gly Gly Glu Arg 
                245                 250                 255     


Arg Leu Ala Glu Ile Leu Thr Glu Asp Gln Leu Trp Pro Gln Pro Asp 
            260                 265                 270         


Glu Gln Ile Leu Arg Asp Ile Leu Glu Gly Glu Ala Leu Ser Leu Thr 
        275                 280                 285             


Leu Leu Thr Pro Ala Ile Phe Lys Asp Gly Trp Leu Pro Cys Gln Gln 
    290                 295                 300                 


Asp Glu Asn Gly His Phe Ile Tyr Arg Pro Pro Asn Thr Asn Thr Leu 
305                 310                 315                 320 


Glu Leu Glu Leu Val Ser Ala Ala Ile Gly Arg Trp Thr Ala Gln Ser 
                325                 330                 335     


Gly Trp Asp Leu Ala Lys His Gln Pro Lys Pro Ser Arg Lys Leu Val 
            340                 345                 350         


Pro Ala Gly Ala Val Tyr Trp Phe Arg Val Arg Glu Gly Asn Lys His 
        355                 360                 365             


Asp Leu Glu Gln Leu Trp Phe Ser Asn Ile Ser Thr Lys Glu Gln Asp 
    370                 375                 380                 


Arg Lys Asp Gly Phe Gly Leu Val Leu Pro His Ser Thr Thr Leu Ser 
385                 390                 395                 400 


Ala Ser Gly Ala Lys 
                405 


<210>  72
<211>  635
<212>  PRT
<213>  Marinomonas mediterranea


<220>
<221>  PEPTIDE
<222>  (1)..(635)
<223>  type III-B CRISPR-associated protein Cas10/Cmr2:  
       /protein_id=WP_013659865.1

<400>  72

Met Asn Thr Tyr Leu Ile Thr Ile Ala Ile Gly Pro Val Gln Ser Leu 
1               5                   10                  15      


Ile Glu Ala Ala Arg Arg Thr Arg Asp Leu Trp Thr Gly Ser Trp Val 
            20                  25                  30          


Leu Ser Glu Cys Ala Lys Ala Ala Ala Lys Ser Leu His Asp Asn Gln 
        35                  40                  45              


Ala Asn Leu Pro Asn Thr Gly Ser Ser Cys Leu Ile Phe Pro Ser Pro 
    50                  55                  60                  


Glu Ser Pro Glu Thr Glu Leu Leu Pro Ser Asp Phe Asn Asp Gln Tyr 
65                  70                  75                  80  


Ala Asn Ile Ser Asn Val Ile Arg Ala Glu Ile Gln Ala Glu Glu Thr 
                85                  90                  95      


Asp Asp Ile Lys Val Ile Ala Glu Gln Ala Lys Gln Ala Ala Lys Asn 
            100                 105                 110         


Arg Leu Thr Ala Ile Ala Glu Ser Ala Leu Asn Ser Ala Lys Gly Leu 
        115                 120                 125             


Pro Ile Arg Arg Asp Leu Trp His Asn Gln Ile Glu His Ile Leu Glu 
    130                 135                 140                 


Met Phe Ala Val Trp Val Lys Val Glu Asp Asn Gln Tyr Gln Thr Ala 
145                 150                 155                 160 


Ser Lys Lys Leu Asn Ala Leu Leu Leu Ala Arg Lys Ala Ser Arg His 
                165                 170                 175     


Phe Glu Asn Pro Glu Ile Ser Glu Glu His Gly Ser Leu Leu Lys Ser 
            180                 185                 190         


Ser Leu Asp Gly Ala Ser Glu Ser Val Val Ala Leu Glu Glu Lys Asp 
        195                 200                 205             


Lys Thr Thr Ser Glu Glu Ser Asn Ser Ile Val Ser Phe Lys Ser Gly 
    210                 215                 220                 


Ser Ile Lys Arg Tyr Lys Arg Lys Leu Gly Leu Ala Asn Lys Glu Val 
225                 230                 235                 240 


Leu Asp Ala Leu Gly Val Ile Lys Arg Leu Ser Gly Lys Ala Glu Gln 
                245                 250                 255     


Phe Thr Pro Tyr Pro Arg Ile Cys Ala Asp Asp Trp Leu Asn Thr Leu 
            260                 265                 270         


Ser Asn Asp Gln Gln Glu Ser Leu Ser Leu His Phe Asp Lys Leu Lys 
        275                 280                 285             


Asn Ala Thr Asp Ser Asp Tyr Gly Asp Ala Cys Leu Val Thr Asp Val 
    290                 295                 300                 


Lys Gly Asn Asn Asn Ala Tyr Ser Asp Phe Pro Phe Asp Gly Glu Leu 
305                 310                 315                 320 


Leu Tyr Asp Phe Arg Leu Gln Asn Ala Leu Gln Asn Thr Glu Arg Asp 
                325                 330                 335     


Lys Ser Leu Ser Thr Ser Glu Gln Arg Val Leu Gly Glu Leu Gln Asn 
            340                 345                 350         


Ser Leu Arg Ser Ile Asn Ser Asn Pro Val Pro Tyr Gly Val Ile Leu 
        355                 360                 365             


Lys Ala Asp Gly Asp Asn Met Gly Glu Leu Phe Ser Gln Ala Gln Ser 
    370                 375                 380                 


Ala Thr Gln Ser Arg Ala Ile Ser Gln Ala Leu His Lys Phe Ala Ser 
385                 390                 395                 400 


Ser Val Arg Gln Leu Val Gln Lys His Gln Gly His Ala Ile Tyr Ala 
                405                 410                 415     


Gly Gly Asp Asp Val Leu Ala Met Leu Pro Leu Asp Gln Ala Ile Pro 
            420                 425                 430         


Cys Ala Glu Gly Leu Ile Asp Glu Phe Ser Asn Cys Met Ser Ser Ile 
        435                 440                 445             


Ile Gln Glu His His Leu Asp Ile Thr Lys Val Pro Ser Leu Ser Val 
    450                 455                 460                 


Gly Leu Ala Ile Gly His Phe Met Gln Pro Leu Gly His Leu Arg Ala 
465                 470                 475                 480 


Arg Ala Val Arg Ala Glu Lys Leu Ala Lys Gly Asp His Leu Pro Ser 
                485                 490                 495     


Asp Lys Lys Arg Asn Ala Leu Ser Ile Cys Leu Gly Leu Arg Ser Gly 
            500                 505                 510         


Pro Glu Val Ser Trp Arg Cys Arg Trp Asp Asp Glu Glu Thr Ile Asn 
        515                 520                 525             


Ala Leu Lys Thr Val Met Asn Ala Tyr Ser Gly Asn Ala Gln Glu Leu 
    530                 535                 540                 


Ser Ser Arg Thr Gly Phe Ala Ile Arg Ser Val Ala Leu Gln Phe Ala 
545                 550                 555                 560 


Trp Ser Lys Thr Ser Ser Glu Ile Ile Ser Pro Ile Gln Gln Ala Glu 
                565                 570                 575     


Leu Lys Arg Leu Leu Asp Asn Leu Asn Lys Lys Gly Gly Glu His Lys 
            580                 585                 590         


Ile Ser Lys Glu Met Ile Ala Leu Leu Thr Gln Gln Ala Glu His Ile 
        595                 600                 605             


Gly Leu Glu Ala Leu Ala Asp Leu Leu Ile Ile Ala Arg Trp Leu Ser 
    610                 615                 620                 


Ala Lys Ala Met Ser Asp Leu Gly Ala Met Glu 
625                 630                 635 


<210>  73
<211>  423
<212>  PRT
<213>  Marinomonas mediterranea


<220>
<221>  PEPTIDE
<222>  (1)..(423)
<223>  type III-B CRISPR module RAMP protein Cmr1: 
       /protein_id=WP_013659866.1

<400>  73

Met Ala Arg Thr Arg Leu Val Asp Ser Ser Gln Leu Asp Ala Leu Gln 
1               5                   10                  15      


Ser Ala Leu Ser Ser Leu Asp Gln Glu Ser Gln Trp Gln Thr Tyr Glu 
            20                  25                  30          


Cys Thr Leu Ile Thr Pro Met Tyr Gly Gly Gly Val Glu Ala Gly Glu 
        35                  40                  45              


Val Asp Lys Gln Met Pro Ile Arg Ala Ser Glu Ile Arg Gly His Leu 
    50                  55                  60                  


Arg Phe Trp Trp Arg Leu Leu Tyr Gly Thr Gln Asp Ser Lys Glu Thr 
65                  70                  75                  80  


Phe Asp Arg Glu Lys Ala Ile Trp Gly Gly Ile Ala Ala Asn Pro Lys 
                85                  90                  95      


Asp Ile Lys Lys Ser Leu Val Ser Ile Lys Val Thr Thr His Ala Pro 
            100                 105                 110         


Ile His Leu Lys Pro Ser Thr Thr Tyr Thr Asp Val Lys Asn Gly Asn 
        115                 120                 125             


Thr Asn Lys Ile Asn Lys Asn Ser Leu Gly Tyr Ala Phe Gly Ala Ala 
    130                 135                 140                 


Ser Ile Leu Thr Glu Asn Glu Glu Asp Ile Cys Trp Leu Ser Glu Gly 
145                 150                 155                 160 


Thr Arg Phe Thr Leu Tyr Ile Lys Leu Asp Ile Pro Glu Pro Ser His 
                165                 170                 175     


Lys Asn Lys Glu Asp Ile Glu Glu Gln Ile Asn Ser Ser Ile Lys Tyr 
            180                 185                 190         


Trp Ala Asn Phe Gly Gly Leu Gly Ala Arg Thr Arg Arg Gly Phe Gly 
        195                 200                 205             


Ser Ile Tyr Ser Ser Ala Phe Ser Ile Lys Ser Asn Thr Glu Ile Glu 
    210                 215                 220                 


Ser Leu Ile Lys Lys Leu Thr Asn Ser Lys Phe Ala Leu Leu Gln Ser 
225                 230                 235                 240 


Lys Ser Ala Ser Ala Val Thr Ala Trp Glu Thr Ala Ser Gln Arg Leu 
                245                 250                 255     


Ser Ser Phe Arg Gln Ile Gly Ile Gly Arg Lys Ser His Lys Asn Arg 
            260                 265                 270         


Ser Thr Trp Pro Glu Pro Asp Gln Leu Arg Arg Phe Thr Asp Lys Asn 
        275                 280                 285             


Asp Asn Gly Lys His Lys Pro Glu His Lys Ala Gly Asn Val Phe Pro 
    290                 295                 300                 


Arg Ala Ala Phe Gly Met Pro Ile Leu Phe Lys Phe Lys Ser Ser Ser 
305                 310                 315                 320 


Asp Pro Gln Thr Leu Arg Leu Leu Pro Gln Gly Ala Glu Arg Phe Ala 
                325                 330                 335     


Ser Pro Leu Ile Ile Arg Pro Ile Gln Leu Gln Glu Gly Cys Val Ala 
            340                 345                 350         


Ile Ala Leu Leu Leu Pro Asn Trp Gln Gln Ala Leu Thr Gln Glu Leu 
        355                 360                 365             


Glu Leu Gln Thr Glu Lys Asp Asp Thr Phe Leu Val Ala Asn Lys Glu 
    370                 375                 380                 


Pro Pro Met Ser Trp Gly Glu Arg Asn Gly Ala Glu Leu Ala Ser Leu 
385                 390                 395                 400 


Ile Thr Pro Met Gln Gly Arg Ala Asp Asn Pro Leu Glu Ala Phe Leu 
                405                 410                 415     


Asp Tyr Phe Glu Lys Gly Arg 
            420             


<210>  74
<211>  300
<212>  PRT
<213>  Methanothermobacter thermautotrophicus


<220>
<221>  PEPTIDE
<222>  (1)..(300)
<223>  hypothetical protein: /protein_id=WP_010875962.1

<400>  74

Met Trp Arg Thr Ile Asn Val Val Phe Lys Leu Lys Thr Pro Leu His 
1               5                   10                  15      


Ile Gly Tyr Leu Pro Ser Lys Ser Ser Val Val Ser Pro Thr Arg Tyr 
            20                  25                  30          


Tyr Ile Pro Gly Arg Asn Leu Trp Gly Ala Val Thr Lys Arg Thr Ala 
        35                  40                  45              


Glu Asn Leu Phe Lys Lys Pro Ala Ala His His Tyr Lys Asn Thr Gly 
    50                  55                  60                  


Lys Asp Ile Met Asn Asn Phe Val Phe Ser Tyr Phe Tyr Ile Tyr Asp 
65                  70                  75                  80  


Gly Lys Thr Ile Tyr Ser Pro Ser Tyr Thr Asp Glu Gly Ile Lys Tyr 
                85                  90                  95      


Gly His Asp Ile Lys Ile Thr Arg Ala Glu Phe Glu His Arg Phe Ile 
            100                 105                 110         


Gly Ser Gln Ile Ser Thr Ala Ile Glu Pro Gly Phe Ser Thr Ala Lys 
        115                 120                 125             


Asp Gln Ser Leu His Glu Ile Glu Phe Ile Asn Asn Lys Ser Cys Asp 
    130                 135                 140                 


Lys Thr Glu Thr Pro Glu Asp Val Lys Val Thr Gly Trp Ile Trp Ile 
145                 150                 155                 160 


Lys Glu Asp Ala Lys Ile Asn Asn Arg Glu Val Asp Val Asp Ala Gly 
                165                 170                 175     


Ile Phe Ile Asp Asn Phe Asn Ile Ile Gln Glu Leu Ile Leu Gly Gly 
            180                 185                 190         


Glu Ser Lys Tyr Gly Phe Gly His Val Leu Leu Asp Gly Val Asn Lys 
        195                 200                 205             


Ile Asp Pro Pro Phe Glu Val Lys Val Glu Asp Ser Val Thr Val Ser 
    210                 215                 220                 


Ser Glu Phe Leu Ile Ser His Leu Lys Tyr Asp Lys Asn Leu Asn Phe 
225                 230                 235                 240 


Met Gly Asp Leu Glu Leu Leu Ala Gly Arg Gly Tyr Phe Asp Pro Glu 
                245                 250                 255     


Thr Arg Arg Gly Gly Ser Gly Pro Gly Ala Thr Ile Ser Lys Pro Gln 
            260                 265                 270         


Tyr Tyr Phe Thr Pro Gly Thr Lys Leu Glu Asp Lys Thr Tyr Phe Gln 
        275                 280                 285             


Met Arg Trp Asp Gly Lys Leu Met Arg Leu Ser Ala 
    290                 295                 300 


<210>  75
<211>  113
<212>  PRT
<213>  Methanothermobacter thermautotrophicus


<220>
<221>  PEPTIDE
<222>  (1)..(113)
<223>  hypothetical protein: /protein_id=WP_010875963.1

<400>  75

Met Gln Cys Ala Gln Lys Ile Ala Val Lys Ser Asp Arg Asn Leu Ala 
1               5                   10                  15      


Asn His Leu Arg Lys Ala Leu Gly Val Leu Gln Glu Asp Gly Val Tyr 
            20                  25                  30          


Ala Met Phe Leu Trp Leu Glu Asp Lys Glu Lys Lys Arg Val Arg Lys 
        35                  40                  45              


Glu Leu Thr Asp Met Leu Asn Arg Pro Glu Ile Arg Glu Cys Leu Leu 
    50                  55                  60                  


Glu Asp Ser Ser Ser Phe Pro Asp Ser Phe Lys Glu Phe Cys Glu Arg 
65                  70                  75                  80  


Leu Arg Asp Val Ala Arg Asp Ile Tyr Lys Leu Leu Phe Met Lys Arg 
                85                  90                  95      


Leu Ile Glu Arg Thr Leu Ile Tyr Ser Leu Tyr His Ala Lys Ala Gly 
            100                 105                 110         


Glu 
    


<210>  76
<211>  287
<212>  PRT
<213>  Methanothermobacter thermautotrophicus


<220>
<221>  PEPTIDE
<222>  (1)..(287)
<223>  type III-B CRISPR module RAMP protein Cmr4:  
       /protein_id=WP_010875964.1

<400>  76

Met Asn Arg Ser Leu Glu Pro Glu Lys Val Tyr Ala Arg Ala Leu Asp 
1               5                   10                  15      


Pro Val His Ile Gly Ala Gly Gly Tyr Arg Leu Gly Arg Ala Asp Asn 
            20                  25                  30          


Thr Ile Val Arg Glu Pro Ser Thr Asp Ile Pro Lys Ile Pro Gly Thr 
        35                  40                  45              


Ser Ile Ala Gly Val Thr Arg Glu Phe Tyr Thr Ala Tyr Leu Ala Glu 
    50                  55                  60                  


Asn Glu Phe Gly Asp Lys Ser Ala Glu Glu Lys Arg Lys Arg Ala Glu 
65                  70                  75                  80  


Glu Lys Ala Lys Ser Ile Phe Gly Asp Glu Asn Lys Lys Gly Val Leu 
                85                  90                  95      


Arg Phe Tyr Asp Gly Gln Ile Leu Phe Phe Pro Val Ser Ser Val Arg 
            100                 105                 110         


Gly Thr Val Trp Ile Thr Thr Glu Gln Leu Phe Asn Tyr Trp Cys Val 
        115                 120                 125             


Lys Asp Glu Lys Ile Ser Tyr Glu Asp Glu Asn Lys Val Tyr Ala Ile 
    130                 135                 140                 


Arg Gly Glu Leu Asn Gly Arg Leu Asn Leu Gly Trp Leu Leu Phe Glu 
145                 150                 155                 160 


Val Asn Ser Glu Lys Lys Glu Asp Val Asp Leu Pro Asp Glu Ile Asn 
                165                 170                 175     


Glu Trp Ile Lys Arg Ala Val Ile Val Pro Glu Asn Leu Phe Ser Pro 
            180                 185                 190         


Ile Val Asn Asp Asn Leu Glu Val Arg Thr Ser Val Arg Ile Asp Pro 
        195                 200                 205             


Glu Thr Gly Thr Ala Val Glu Gly Ala Leu Phe Thr Tyr Glu Ala Ile 
    210                 215                 220                 


Pro Arg Gly Thr Ile Phe Gly Phe Glu Ile Ala Thr Glu Lys Asp Glu 
225                 230                 235                 240 


Lys Arg Lys Glu Val Leu Asn Ala Val Ser Pro Tyr Leu Lys Tyr Leu 
                245                 250                 255     


Gly Ile Gly Gly Met Val Thr Arg Gly Phe Gly Arg Leu Glu Leu Ala 
            260                 265                 270         


Ala Glu His Ser Glu Asp Glu Gln Val Gly Thr Asp Val Lys Pro 
        275                 280                 285         


<210>  77
<211>  957
<212>  PRT
<213>  Methanothermobacter thermautotrophicus


<220>
<221>  PEPTIDE
<222>  (1)..(957)
<223>  CRISPR-associated protein Csx11:  /protein_id=WP_010875965.1

<400>  77

Met Ser Asn Ile Lys Asn Ile Arg Lys Arg Arg Lys Glu Val Leu Leu 
1               5                   10                  15      


Gly Glu Ile Gly Ala Leu Leu His Asp Ile Gly Lys Leu His Pro Asn 
            20                  25                  30          


Phe Ile Gly Thr Asn Ser Ile Glu Lys Met Pro Pro Arg Phe Phe His 
        35                  40                  45              


Ala Asn Ile Asp Asp Phe Leu Lys Thr Glu Leu Ile Ser Ala Leu Lys 
    50                  55                  60                  


Ala Phe Glu Asp Leu Glu Ile Asn Val Glu Pro Ile Arg Ile Tyr Asn 
65                  70                  75                  80  


Ile Ile Ser Glu His His Arg Asn Asn Val Leu Gln Gly Cys Asp Arg 
                85                  90                  95      


Lys Asp Ser Ala Asp Asp Lys Gly Ile Val Arg Arg Lys Gln Ser Ile 
            100                 105                 110         


Thr Asp Thr Val Ile Ser Ser Pro Phe Gly Tyr Pro Lys Glu Lys Ile 
        115                 120                 125             


His Leu Asn Cys Leu Gln Lys Glu Phe Asp Asp Leu Gln Thr Ile Leu 
    130                 135                 140                 


Val Arg Leu Phe Lys Tyr Tyr Ile Ser Gly Val Val Asn Leu Ser Leu 
145                 150                 155                 160 


Phe Arg Arg Met Leu Met Lys Glu Ala Gln Val Phe Phe Ser His Gly 
                165                 170                 175     


Leu Gly Glu Thr Arg Ile Pro Ser Asn Asp Val Thr Leu Trp Asp His 
            180                 185                 190         


Ser Tyr Ser Thr Ala Ser Arg Phe Lys Ser Ile Leu Val Ala Asn Leu 
        195                 200                 205             


Cys Gly Ala Asp Ile Lys Asp Pro Glu Leu Arg Ile Phe Gly Ile Phe 
    210                 215                 220                 


Trp Asn Gly Ile Glu Phe Ile Asn Lys Gly Arg Lys Ile Ala Glu Ile 
225                 230                 235                 240 


Lys Ala Arg Lys Glu Ile Ile Glu Arg Ile Lys Glu Lys Leu Lys Gly 
                245                 250                 255     


Lys Phe Glu Asp Glu Ile Pro Val Gly Asn Ser Ile Tyr Glu Asp Ile 
            260                 265                 270         


Asn Gly Ile Cys Phe Thr Phe Pro Glu Phe Asp Arg Ala Glu Glu Leu 
        275                 280                 285             


Ala Asn Gln Cys Ala Lys Glu Ala Leu Lys Ile Phe Leu Glu Glu Ser 
    290                 295                 300                 


Glu Asn Glu Leu Trp Pro Phe Phe Thr Leu Ser Lys Pro Ser Lys Thr 
305                 310                 315                 320 


Leu Thr Val Leu Ala Ser Glu Leu Lys Phe Ala Ser Ser Arg Arg Val 
                325                 330                 335     


Tyr Pro Lys Ile Thr Pro Ala Leu Phe Ile Asp Lys Lys Gln Lys Lys 
            340                 345                 350         


Ile Ile Ala Asp Asn Pro Glu Met Pro Ile Pro Gln Glu Gly Glu Asp 
        355                 360                 365             


Ile Cys Pro Leu Cys Arg Leu Arg Ala Lys Pro Ile Glu Lys Glu Arg 
    370                 375                 380                 


Cys Glu Ile Cys Ser Glu Arg Ile Arg Gly Arg Leu Ala Asn Trp Ser 
385                 390                 395                 400 


Asn Lys Lys Glu Asn Thr Ile Trp Ile Asp Glu Val Ala Asp Lys Asn 
                405                 410                 415     


Asn Arg Ile Ala Leu Ile Ala Leu Asn Phe Asp Leu Asp Lys Trp Phe 
            420                 425                 430         


Asp Gly Thr Met Val Gly Thr Ile Tyr Ser Gln Thr Tyr Lys Asp Trp 
        435                 440                 445             


Lys His Ser Lys Lys Trp Glu Lys Lys Asn Val Lys Lys Asn Ala Asn 
    450                 455                 460                 


Ser Val Leu Asn Gly Pro Ile Glu Ala Ile Lys Asp His Val Tyr Lys 
465                 470                 475                 480 


Ile Leu Asn Tyr Ile Leu Glu Asn Glu Asp Ser Asn Glu Glu Lys Ala 
                485                 490                 495     


Ala Lys Leu Leu Asp Thr Phe Phe Glu Glu Glu Ile Gly Leu Arg Asn 
            500                 505                 510         


Lys Lys Asp Leu Lys Lys Glu Phe Lys Asn His Leu Gln Asn Ile Arg 
        515                 520                 525             


Glu Asn Ile Gly Ala Asp Leu Asn Lys Glu Asn Leu Ala Thr Tyr Leu 
    530                 535                 540                 


Phe Thr Gln Asn Pro Ser Pro Ala Arg Leu Tyr Arg Ile Trp Lys Glu 
545                 550                 555                 560 


Thr Glu Glu Phe Phe Asp Leu Leu Ile Asn Lys Ile Thr Asp Ile Tyr 
                565                 570                 575     


Ala Tyr Arg Trp Lys Arg Ile Gly Phe Ser Ile Asp Thr His Glu Leu 
            580                 585                 590         


Lys Gly Arg Leu Lys Glu Glu Tyr Lys Asn Ile Lys Glu Leu Glu Lys 
        595                 600                 605             


Gly Ser Leu Ile Ile Lys Ile Ser Gly Leu Asp Pro Glu Thr Leu Leu 
    610                 615                 620                 


Val Phe His Asp Arg Asn Gly Glu Phe Tyr Thr Ile Glu Ser Leu Gly 
625                 630                 635                 640 


Lys Phe Lys Phe Lys Asn Lys Val Gly Glu Glu Ala Val Lys Glu Ala 
                645                 650                 655     


Leu Lys Gln Gly Ile Lys His Leu Ala Pro Glu Asp Glu Pro Glu Lys 
            660                 665                 670         


Asn Leu Ile Glu Val Gly Lys Thr Ile Lys Thr Glu Asp Asn Leu Tyr 
        675                 680                 685             


Phe Glu Lys Tyr Tyr Pro Leu Ile Glu Ile Asn Arg Ser Pro Leu Ser 
    690                 695                 700                 


Leu Arg Phe Ile Val Pro Ala Leu Asp Ser Val Lys Ile Ile Glu Met 
705                 710                 715                 720 


Ile Ala Glu Leu Tyr Asn Lys Arg Phe Glu Lys Val Leu Gly Lys Leu 
                725                 730                 735     


Pro Leu Asn Leu Lys Leu Leu Val Ala Lys Arg Lys Phe Pro Leu Tyr 
            740                 745                 750         


Ile Leu Leu Glu Ala Glu Lys Arg Met Leu Lys Asp Glu Glu Phe Lys 
        755                 760                 765             


Lys Gln Thr Pro Met Asp Pro Trp Trp Ser Val Glu Arg Leu Asp Glu 
    770                 775                 780                 


His Tyr Asn Phe Tyr Pro Ile Lys Pro Ala Asn Gly Glu Lys Tyr Thr 
785                 790                 795                 800 


Leu Asp Asp Leu Ser Arg Leu Ser Arg Gly Lys Ile Phe Tyr Leu Tyr 
                805                 810                 815     


Pro Gly Tyr Phe Asp Phe Glu Leu Leu Ser Ala Thr Thr Asp Arg Tyr 
            820                 825                 830         


Asn Ile Cys Tyr Glu Gly Lys Lys Arg Gly His Glu Asp His Arg Leu 
        835                 840                 845             


Phe Ser Gly Arg Pro Leu Tyr Phe His Gln Ile Pro Gln Ile Leu Glu 
    850                 855                 860                 


Leu Trp Asp Leu Leu Ser Ser Asn Leu Ser Asn Ser Gln Ile Asn Phe 
865                 870                 875                 880 


Ile Glu Lys Ala Leu Thr Ser Lys Leu Arg Glu Trp Lys Asn Val Lys 
                885                 890                 895     


Asp Ala Asn Lys Glu Asn Thr Phe Arg Ile Phe Ala Glu Thr Thr Leu 
            900                 905                 910         


Lys Asp Ala Phe Gly His Lys Trp Asp Gly Leu Arg Glu Glu Asn Arg 
        915                 920                 925             


Phe Phe Leu Ile Ser Ser Ser Ile Asn Met Leu Leu Leu Asp Thr Ile 
    930                 935                 940                 


Asn Leu Phe Thr His Val Thr Gly Cys Leu Lys Asp Glu 
945                 950                 955         


<210>  78
<211>  261
<212>  PRT
<213>  Methanothermobacter thermautotrophicus


<220>
<221>  PEPTIDE
<222>  (1)..(261)
<223>  hypothetical protein:  /protein_id=WP_010875966.1

<400>  78

Met Asn Leu Asp Gly Val Tyr Asp Phe Tyr Leu His Glu Lys Glu Gly 
1               5                   10                  15      


Gly Ile Glu Glu Pro Lys Arg Lys Ile Met Asp Ala Val Ala Gly Asp 
            20                  25                  30          


His Lys Asp Asp Phe Lys Thr Phe Tyr Pro Ser Pro Asp Asp Leu Asn 
        35                  40                  45              


Tyr Leu Pro Met Asn Ser Val Leu Ile Gly Phe Gln Phe Thr Leu Lys 
    50                  55                  60                  


Lys Pro Tyr Thr Ser Arg Gly Glu Ser Lys Phe Ser Glu Asn Leu Ile 
65                  70                  75                  80  


Val Arg Asp Gln Phe Thr Gly Leu Cys Met Val Arg Pro Ser Thr Trp 
                85                  90                  95      


Lys Gly Asn Leu Arg Phe Ala Ala Thr Lys Leu Met Gly Pro Lys Asn 
            100                 105                 110         


Ser Ile Ile Ile Arg Leu Phe Gly Ser Asn Pro Asp Ser Glu Asp Met 
        115                 120                 125             


Ile Lys Gly Arg Leu Tyr Phe Phe Pro Thr Phe Phe Lys Glu Gly Ala 
    130                 135                 140                 


Glu Asn Asp Val Ile Thr Pro Leu Lys Arg Glu Thr Arg Thr Pro Ala 
145                 150                 155                 160 


Arg Gly Pro Ile Pro Leu Glu Val Met Lys Pro Gly Thr Lys Gly Asp 
                165                 170                 175     


Phe Tyr Leu Leu Tyr Val Pro Tyr Leu Gly Asn Glu Asn Phe Gly Asp 
            180                 185                 190         


Glu Ile Lys Glu Asp Leu Lys Leu Ile Ala Glu Ala Leu Lys Leu Met 
        195                 200                 205             


Phe Tyr Thr Tyr Gly Phe Ser Ala Lys Arg Thr Ser Gly Phe Gly Val 
    210                 215                 220                 


Ile Glu Lys Gln Leu Glu Gly Lys Leu Trp Met Arg Gly Gly Val Ser 
225                 230                 235                 240 


Lys Asn Phe Ser Asn Leu His Glu Leu Ser Glu Ile Leu Asp Gly Tyr 
                245                 250                 255     


Gly Tyr Glu Gln His 
            260     


<210>  79
<211>  251
<212>  PRT
<213>  Methanothermobacter thermautotrophicus


<220>
<221>  PEPTIDE
<222>  (1)..(251)
<223>  type III-B CRISPR module RAMP protein Cmr1: 
       /protein_id=WP_010875967.1

<400>  79

Met Arg Gly Cys Ser Met Gly Gly Pro Arg Thr Phe Asn Ile Glu Leu 
1               5                   10                  15      


Gln Ile Leu Asn Glu Ile Phe Thr Gly Gly Pro Glu Arg Arg Ser Glu 
            20                  25                  30          


Val Ile Arg Asp Thr Gly Leu Ile Gly Ser Leu Arg Trp Trp Tyr Glu 
        35                  40                  45              


Ala Leu Ile Arg Gly Val Gly Gly Thr Ala Cys Asp Pro Ser Gln Gly 
    50                  55                  60                  


Pro Pro Cys Glu Glu Arg Leu His Cys Asp Ala Cys Glu Leu Phe Gly 
65                  70                  75                  80  


Cys Ser Gly Trp Ser Arg Lys Phe Ile Phe Arg Ser Arg Glu Glu Ser 
                85                  90                  95      


Asp Lys Thr Leu Lys Val Gln Ile Thr Glu Leu Arg Arg Met Glu Asp 
            100                 105                 110         


Val Glu Leu Ala Leu Leu Asn Lys Thr Leu Ser Ile Ile Glu Asn Tyr 
        115                 120                 125             


Gly Ala Ile Gly Gly Lys Leu Ala His Arg Lys Tyr Gly Ile Ile Lys 
    130                 135                 140                 


Ile Lys Glu Asn Asp Leu Arg Asp Phe Thr Leu Glu Lys Ser Met Leu 
145                 150                 155                 160 


Gln Gly Tyr Leu Arg Arg Glu Gly Pro His Val Asp Asn Pro Asn Leu 
                165                 170                 175     


Lys Arg Phe Ile Phe Ile Lys Asn Pro Asn Phe Gln Leu Val Lys Arg 
            180                 185                 190         


Leu Lys Asn Asp Cys Arg Phe Leu Lys Gly Ser Ser Asn Arg Gly Lys 
        195                 200                 205             


Arg Tyr Phe Asn Lys Asp Pro Pro Gly Ser Arg Leu Phe Ala Tyr Ala 
    210                 215                 220                 


Asn Glu Asp Glu Tyr Pro Arg Leu Cys Glu Cys Ala Gly Glu Glu Ala 
225                 230                 235                 240 


Lys Thr Gly Glu Glu Val Leu Gly Gly Leu Ile 
                245                 250     


<210>  80
<211>  795
<212>  PRT
<213>  Synechocystis spp


<220>
<221>  PEPTIDE
<222>  (1)..(795)
<223>  TIGR03986 family CRISPR-associated RAMP protein  
       /protein_id=WP_011153732.1

<400>  80

Met Thr Val Gly Thr Leu Gly Val Val Gly Ser Ala Lys Asn Leu Lys 
1               5                   10                  15      


Leu Gln Leu Ser Phe Ile Asn Thr Arg Gln Gln Tyr Val Gln Ile Thr 
            20                  25                  30          


Leu Phe Glu Arg Asn Ser Phe Lys Val Ala Glu Glu Glu Phe Ser Thr 
        35                  40                  45              


Glu Leu Val Glu Ile Ile Lys Thr Ala Leu Pro Thr Leu Lys Asn Lys 
    50                  55                  60                  


Lys Val Glu Phe Glu Glu Asp Gly Asp Gln Ile Lys Gln Ile Arg Glu 
65                  70                  75                  80  


Lys Gly Gln Ala Trp Val Gly Ala Ala Glu Gln Ile Ala Pro Tyr Val 
                85                  90                  95      


Leu Pro Ser Gly Asn Ile Thr Glu Thr Pro Arg Asn Val Asn Ala Ser 
            100                 105                 110         


Asn Phe His Asn Pro Tyr Asn Phe Val Pro Ala Leu Pro Arg Asp Gly 
        115                 120                 125             


Ile Thr Gly Asp Leu Gly Asp Cys Ala Pro Ala Gly His Ser Tyr Tyr 
    130                 135                 140                 


His Gly Asp Lys Tyr Ser Gly Arg Ile Ala Val Lys Leu Thr Thr Val 
145                 150                 155                 160 


Thr Pro Leu Leu Ile Pro Asp Ala Ser Lys Glu Glu Ile Asn Asn Asn 
                165                 170                 175     


His Lys Thr Tyr Pro Val Arg Ile Gly Lys Asp Gly Lys Pro Tyr Leu 
            180                 185                 190         


Pro Pro Thr Ser Ile Lys Gly Met Leu Arg Ser Ala Tyr Glu Ala Val 
        195                 200                 205             


Thr Asn Ser Arg Leu Ala Val Phe Glu Asp His Asp Ser Arg Leu Ala 
    210                 215                 220                 


Tyr Arg Met Pro Ala Thr Met Gly Leu Gln Met Val Pro Ala Arg Ile 
225                 230                 235                 240 


Glu Gly Asp Asn Ile Val Leu Tyr Pro Gly Thr Ser Arg Ile Gly Asn 
                245                 250                 255     


Asn Gly Arg Pro Ala Asn Asn Asp Pro Met Tyr Ala Ala Trp Leu Pro 
            260                 265                 270         


Tyr Tyr Gln Asn Arg Ile Ala Tyr Asp Gly Ser Arg Asp Tyr Gln Met 
        275                 280                 285             


Ala Glu His Gly Asp His Val Arg Phe Trp Ala Glu Arg Tyr Thr Arg 
    290                 295                 300                 


Gly Asn Phe Cys Tyr Trp Arg Val Arg Gln Ile Ala Arg His Asn Gln 
305                 310                 315                 320 


Asn Leu Gly Asn Arg Pro Glu Arg Gly Arg Asn Tyr Gly Gln His His 
                325                 330                 335     


Ser Thr Gly Val Ile Glu Gln Phe Glu Gly Phe Val Tyr Lys Thr Asn 
            340                 345                 350         


Lys Asn Ile Gly Asn Lys His Asp Glu Arg Val Phe Ile Ile Asp Arg 
        355                 360                 365             


Glu Ser Ile Glu Ile Pro Leu Ser Arg Asp Leu Arg Arg Lys Trp Arg 
    370                 375                 380                 


Glu Leu Ile Thr Ser Tyr Gln Glu Ile His Lys Lys Glu Val Asp Arg 
385                 390                 395                 400 


Gly Asp Thr Gly Pro Ser Ala Val Asn Gly Ala Val Trp Ser Arg Gln 
                405                 410                 415     


Ile Ile Ala Asp Glu Ser Glu Arg Asn Leu Ser Asp Gly Thr Leu Cys 
            420                 425                 430         


Tyr Ala His Val Lys Lys Glu Asp Gly Gln Tyr Lys Ile Leu Asn Leu 
        435                 440                 445             


Tyr Pro Val Met Ile Thr Arg Gly Leu Tyr Glu Ile Ala Pro Val Asp 
    450                 455                 460                 


Leu Leu Asp Glu Thr Leu Lys Pro Ala Thr Asp Lys Lys Gln Leu Ser 
465                 470                 475                 480 


Pro Ala Asp Arg Val Phe Gly Trp Val Asn Gln Arg Gly Asn Gly Cys 
                485                 490                 495     


Tyr Lys Gly Gln Leu Arg Ile His Ser Val Thr Cys Gln His Asp Asp 
            500                 505                 510         


Ala Ile Asp Asp Phe Gly Asn Gln Asn Phe Ser Val Pro Leu Ala Ile 
        515                 520                 525             


Leu Gly Gln Pro Lys Pro Glu Gln Ala Arg Phe Tyr Cys Ala Asp Asp 
    530                 535                 540                 


Arg Lys Gly Ile Pro Leu Glu Asp Gly Tyr Asp Arg Asp Asp Gly Tyr 
545                 550                 555                 560 


Ser Asp Ser Glu Gln Gly Leu Arg Gly Arg Lys Val Tyr Pro His His 
                565                 570                 575     


Lys Gly Leu Pro Asn Gly Tyr Trp Ser Asn Pro Thr Glu Asp Arg Ser 
            580                 585                 590         


Gln Gln Ala Ile Gln Gly His Tyr Gln Glu Tyr Arg Arg Pro Lys Lys 
        595                 600                 605             


Asp Gly Leu Glu Gln Arg Asp Asp Gln Asn Arg Ser Val Lys Gly Trp 
    610                 615                 620                 


Val Lys Pro Leu Thr Glu Phe Thr Phe Glu Ile Asp Val Thr Asn Leu 
625                 630                 635                 640 


Ser Glu Val Glu Leu Gly Ala Leu Leu Trp Leu Leu Thr Leu Pro Asp 
                645                 650                 655     


Leu His Phe His Arg Leu Gly Gly Gly Lys Pro Leu Gly Phe Gly Ser 
            660                 665                 670         


Val Arg Leu Asp Ile Asp Pro Asp Lys Thr Asp Leu Arg Asn Gly Ala 
        675                 680                 685             


Gly Trp Arg Asp Tyr Tyr Gly Ser Leu Leu Glu Thr Ser Gln Pro Asp 
    690                 695                 700                 


Phe Thr Thr Leu Ile Ser Gln Trp Ile Asn Ala Phe Gln Thr Ala Val 
705                 710                 715                 720 


Lys Glu Glu Tyr Gly Ser Ser Ser Phe Asp Gln Val Thr Phe Ile Lys 
                725                 730                 735     


Ala Ser Gly Gln Ser Leu Gln Gly Phe His Asp Asn Ala Ser Ile His 
            740                 745                 750         


Tyr Pro Arg Ser Thr Pro Glu Pro Lys Pro Asp Gly Glu Ala Phe Lys 
        755                 760                 765             


Trp Phe Val Ala Asn Glu Lys Gly Arg Arg Leu Ala Leu Pro Ala Leu 
    770                 775                 780                 


Glu Lys Ser Gln Ser Phe Pro Ile Lys Pro Ser 
785                 790                 795 


<210>  81
<211>  193
<212>  PRT
<213>  Synechocystis spp


<220>
<221>  PEPTIDE
<222>  (1)..(193)
<223>  TIGR03984 family CRISPR-associated protein 
       /protein_id=WP_011153733.1

<400>  81

Met Pro Ala Gly Gly Arg Leu Met Lys Asn Leu Tyr His Tyr His Gln 
1               5                   10                  15      


Tyr Glu Ile Thr Leu Glu Ser Ala Val Asp Ser Cys Lys Asn His Leu 
            20                  25                  30          


Gln Ala Ala Ile Gly Leu Leu Tyr Ser Pro Gln Lys Cys Glu Leu Val 
        35                  40                  45              


Lys Leu Asp Asn Ser Gly Lys Leu Val Asp Ser Tyr Asn Arg Leu Lys 
    50                  55                  60                  


Phe Asn Asn Leu Gly Val Phe Glu Ala Arg Phe Phe Asn Leu Asn Cys 
65                  70                  75                  80  


Glu Leu Arg Trp Val Asn Glu Ser Asn Gly Asn Gly Thr Ala Val Leu 
                85                  90                  95      


Leu Ser Glu Ser Asp Ile Thr Leu Thr Gly Phe Glu Lys Gly Leu Gln 
            100                 105                 110         


Glu Phe Ile Thr Ala Ile Asp Gln Gln Tyr Leu Leu Trp Gly Glu Pro 
        115                 120                 125             


Ala Lys His Pro Pro Asn Ala Asp Gly Trp Gln Arg Leu Ala Glu Ala 
    130                 135                 140                 


Arg Ile Gly Lys Leu Asp Ile Pro Leu Asp Asn Pro Leu Lys Pro Lys 
145                 150                 155                 160 


Asp Arg Val Phe Leu Thr Ser Glu Glu Tyr Ile Ala Glu Val Asp Asp 
                165                 170                 175     


Phe Gly Asn Cys Ala Val Ile Asp Glu Arg Leu Ile Lys Leu Glu Val 
            180                 185                 190         


Lys 
    


<210>  82
<211>  522
<212>  PRT
<213>  Synechocystis spp


<220>
<221>  PEPTIDE
<222>  (1)..(522)
<223>  hypothetical protein:  /protein_id=WP_011153734.1

<400>  82

Met Ala Arg Lys Val Thr Thr Arg Trp Lys Ile Thr Gly Thr Leu Ile 
1               5                   10                  15      


Ala Glu Thr Pro Leu His Ile Gly Gly Val Gly Gly Asp Ala Asp Thr 
            20                  25                  30          


Asp Leu Ala Leu Ala Val Asn Gly Ala Gly Glu Tyr Tyr Val Pro Gly 
        35                  40                  45              


Thr Ser Leu Ala Gly Ala Leu Arg Gly Trp Met Thr Gln Leu Leu Asn 
    50                  55                  60                  


Asn Asp Glu Ser Gln Ile Lys Asp Leu Trp Gly Asp His Leu Asp Ala 
65                  70                  75                  80  


Lys Arg Gly Ala Ser Phe Val Ile Val Asp Asp Ala Val Ile His Ile 
                85                  90                  95      


Pro Asn Asn Ala Asp Val Glu Ile Arg Glu Gly Val Gly Ile Asp Arg 
            100                 105                 110         


His Phe Gly Thr Ala Ala Asn Gly Phe Lys Tyr Ser Arg Ala Val Ile 
        115                 120                 125             


Pro Lys Gly Ser Lys Phe Lys Leu Pro Leu Thr Phe Asp Ser Gln Asp 
    130                 135                 140                 


Asp Gly Leu Pro Asn Ala Leu Ile Gln Leu Leu Cys Ala Leu Glu Ala 
145                 150                 155                 160 


Gly Asp Ile Arg Leu Gly Ala Ala Lys Thr Arg Gly Leu Gly Arg Ile 
                165                 170                 175     


Lys Leu Asp Asp Leu Lys Leu Lys Ser Phe Ala Leu Asp Lys Pro Glu 
            180                 185                 190         


Gly Ile Phe Ser Ala Leu Leu Asp Gln Gly Lys Lys Leu Asp Trp Asn 
        195                 200                 205             


Gln Leu Lys Ala Asn Val Thr Tyr Gln Ser Pro Pro Tyr Leu Gly Ile 
    210                 215                 220                 


Ser Ile Thr Trp Asn Pro Lys Asp Pro Val Met Val Lys Ala Glu Gly 
225                 230                 235                 240 


Asp Gly Leu Ala Ile Asp Ile Leu Pro Leu Val Ser Gln Val Gly Ser 
                245                 250                 255     


Asp Val Arg Phe Val Ile Pro Gly Ser Ser Ile Lys Gly Ile Leu Arg 
            260                 265                 270         


Thr Gln Ala Glu Arg Ile Ile Arg Thr Ile Cys Gln Ser Asn Gly Ser 
        275                 280                 285             


Glu Lys Asn Phe Leu Glu Gln Leu Arg Ile Asn Leu Val Asn Glu Leu 
    290                 295                 300                 


Phe Gly Ser Ala Ser Leu Ser Gln Lys Gln Asn Gly Lys Asp Ile Asp 
305                 310                 315                 320 


Leu Gly Lys Ile Gly Ala Leu Ala Val Asn Asp Cys Phe Ser Ser Leu 
                325                 330                 335     


Ser Met Thr Pro Asp Gln Trp Lys Ala Val Glu Asn Ala Thr Glu Met 
            340                 345                 350         


Thr Gly Asn Leu Gln Pro Ala Leu Lys Gln Ala Thr Gly Tyr Pro Asn 
        355                 360                 365             


Asn Ile Ser Gln Ala Tyr Lys Val Leu Gln Pro Ala Met His Val Ala 
    370                 375                 380                 


Val Asp Arg Trp Thr Gly Gly Ala Ala Glu Gly Met Leu Tyr Ser Val 
385                 390                 395                 400 


Leu Glu Pro Ile Gly Val Thr Trp Glu Pro Ile Gln Val His Leu Asp 
                405                 410                 415     


Ile Ala Arg Leu Lys Asn Tyr Tyr His Gly Lys Glu Glu Lys Leu Lys 
            420                 425                 430         


Pro Ala Ile Ala Leu Leu Leu Leu Val Leu Arg Asp Leu Ala Asn Lys 
        435                 440                 445             


Lys Ile Pro Val Gly Tyr Gly Thr Asn Arg Gly Met Gly Thr Ile Thr 
    450                 455                 460                 


Val Ser Gln Ile Thr Leu Asn Gly Lys Ala Leu Pro Thr Glu Leu Glu 
465                 470                 475                 480 


Pro Leu Asn Lys Thr Met Thr Cys Pro Asn Leu Thr Asp Leu Asp Glu 
                485                 490                 495     


Ala Phe Arg Gln Asp Leu Ser Thr Ala Trp Lys Glu Trp Ile Ala Asp 
            500                 505                 510         


Pro Ile Asp Leu Cys Gln Gln Glu Ala Ala 
        515                 520         


<210>  83
<211>  791
<212>  PRT
<213>  Synechocystis spp


<220>
<221>  PEPTIDE
<222>  (1)..(791)
<223>  hypothetical protein: /protein_id=WP_011153735.1

<400>  83

Met Arg Gly Ile Glu Ile Thr Ile Thr Met Gln Ser Asp Trp His Val 
1               5                   10                  15      


Gly Thr Gly Met Gly Arg Gly Glu Leu Asp Ser Val Val Gln Arg Asp 
            20                  25                  30          


Gly Asp Asn Leu Pro Tyr Ile Pro Gly Lys Thr Leu Thr Gly Ile Leu 
        35                  40                  45              


Arg Asp Ser Cys Glu Gln Val Ala Leu Gly Leu Asp Asn Gly Gln Thr 
    50                  55                  60                  


Arg Gly Leu Trp His Gly Trp Ile Asn Phe Ile Phe Gly Asp Gln Pro 
65                  70                  75                  80  


Ala Leu Ala Gln Gly Ala Ile Glu Pro Glu Pro Arg Pro Ala Leu Ile 
                85                  90                  95      


Ala Ile Gly Ser Ala His Leu Asp Pro Lys Leu Lys Ala Ala Phe Gln 
            100                 105                 110         


Gly Lys Lys Gln Leu Gln Glu Ala Ile Ala Phe Met Lys Pro Gly Val 
        115                 120                 125             


Ala Ile Asp Ala Ile Thr Gly Thr Ala Lys Lys Asp Phe Leu Arg Phe 
    130                 135                 140                 


Glu Glu Val Val Arg Leu Gly Ala Lys Leu Thr Ala Glu Val Glu Leu 
145                 150                 155                 160 


Asn Leu Pro Asp Asn Leu Ser Glu Thr Asn Lys Lys Val Ile Ala Gly 
                165                 170                 175     


Ile Leu Ala Ser Gly Ala Lys Leu Thr Glu Arg Leu Gly Gly Lys Arg 
            180                 185                 190         


Arg Arg Gly Asn Gly Arg Cys Glu Leu Lys Phe Ser Gly Tyr Ser Asp 
        195                 200                 205             


Gln Gln Ile Gln Trp Leu Lys Asp Asn Tyr Gln Ser Val Asp Gln Pro 
    210                 215                 220                 


Pro Lys Tyr Gln Gln Asn Lys Leu Gln Ser Ala Gly Asp Asn Pro Glu 
225                 230                 235                 240 


Gln Gln Pro Pro Trp His Ile Ile Pro Leu Thr Ile Lys Thr Leu Ser 
                245                 250                 255     


Pro Val Val Leu Pro Ala Arg Thr Val Gly Asn Val Val Glu Cys Leu 
            260                 265                 270         


Asp Tyr Ile Pro Gly Arg Tyr Leu Leu Gly Tyr Ile His Lys Thr Leu 
        275                 280                 285             


Gly Glu Tyr Phe Asp Val Ser Gln Ala Ile Ala Ala Gly Asp Leu Ile 
    290                 295                 300                 


Ile Thr Asn Ala Thr Ile Lys Ile Asp Gly Lys Ala Gly Arg Ala Thr 
305                 310                 315                 320 


Pro Phe Cys Leu Phe Gly Glu Lys Leu Asp Gly Gly Leu Gly Lys Gly 
                325                 330                 335     


Lys Gly Val Tyr Asn Arg Phe Gln Glu Ser Glu Pro Asp Gly Ile Gln 
            340                 345                 350         


Leu Lys Gly Glu Arg Gly Gly Tyr Val Gly Gln Phe Glu Gln Glu Gln 
        355                 360                 365             


Arg Asn Leu Pro Asn Thr Gly Lys Ile Asn Ser Glu Leu Phe Thr His 
    370                 375                 380                 


Asn Thr Ile Gln Asp Asp Val Gln Arg Pro Thr Ser Asp Val Gly Gly 
385                 390                 395                 400 


Val Tyr Ser Tyr Glu Ala Ile Ile Ala Gly Gln Thr Phe Val Ala Glu 
                405                 410                 415     


Leu Arg Leu Pro Asp Ser Leu Val Lys Gln Ile Thr Ser Lys Asn Lys 
            420                 425                 430         


Asn Trp Gln Ala Gln Leu Lys Ala Thr Ile Arg Ile Gly Gln Ser Lys 
        435                 440                 445             


Lys Asp Gln Tyr Gly Lys Ile Glu Val Thr Ser Gly Asn Ser Ala Asp 
    450                 455                 460                 


Leu Pro Lys Pro Thr Gly Asn Asn Lys Thr Leu Ser Ile Trp Phe Leu 
465                 470                 475                 480 


Ser Asp Ile Leu Leu Arg Gly Asp Arg Leu Asn Phe Asn Ala Thr Pro 
                485                 490                 495     


Asp Asp Leu Lys Lys Tyr Leu Glu Asn Ala Leu Asp Ile Lys Leu Lys 
            500                 505                 510         


Glu Arg Ser Asp Asn Asp Leu Ile Cys Ile Ala Leu Arg Ser Gln Arg 
        515                 520                 525             


Thr Glu Ser Trp Gln Val Arg Trp Gly Leu Pro Arg Pro Ser Leu Val 
    530                 535                 540                 


Gly Trp Gln Ala Gly Ser Cys Leu Ile Tyr Asp Ile Glu Ser Gly Thr 
545                 550                 555                 560 


Val Asn Ala Glu Lys Leu Gln Glu Leu Met Ile Thr Gly Ile Gly Asp 
                565                 570                 575     


Arg Cys Thr Glu Gly Tyr Gly Gln Ile Gly Phe Asn Asp Pro Leu Leu 
            580                 585                 590         


Ser Ala Ser Leu Gly Lys Leu Thr Ala Lys Pro Lys Ala Ser Asn Asn 
        595                 600                 605             


Gln Ser Gln Asn Ser Gln Ser Asn Pro Leu Pro Thr Asn His Pro Thr 
    610                 615                 620                 


Gln Asp Tyr Ala Arg Leu Ile Glu Lys Ala Ala Trp Arg Glu Ala Ile 
625                 630                 635                 640 


Gln Asn Lys Ala Leu Ala Leu Ala Ser Ser Arg Ala Lys Arg Glu Glu 
                645                 650                 655     


Ile Leu Gly Ile Lys Ile Met Gly Lys Asp Ser Gln Pro Thr Met Thr 
            660                 665                 670         


Gln Leu Gly Gly Phe Arg Ser Val Leu Lys Arg Leu His Ser Arg Asn 
        675                 680                 685             


Asn Arg Asp Ile Val Thr Gly Tyr Leu Thr Ala Leu Glu Gln Val Ser 
    690                 695                 700                 


Asn Arg Lys Glu Lys Trp Ser Asn Thr Ser Gln Gly Leu Thr Lys Ile 
705                 710                 715                 720 


Arg Asn Leu Val Thr Gln Glu Asn Leu Ile Trp Asn His Leu Asp Ile 
                725                 730                 735     


Asp Phe Ser Pro Leu Thr Ile Thr Gln Asn Gly Val Asn Gln Leu Lys 
            740                 745                 750         


Ser Glu Leu Trp Ala Glu Ala Val Arg Thr Leu Val Asp Ala Ile Ile 
        755                 760                 765             


Arg Gly His Lys Arg Asp Leu Glu Lys Ala Gln Glu Asn Glu Ser Asn 
    770                 775                 780                 


Gln Gln Ser Gln Gly Ala Ala 
785                 790     


<210>  84
<211>  558
<212>  PRT
<213>  Synechocystis spp


<220>
<221>  PEPTIDE
<222>  (1)..(558)
<223>  hypothetical protein/protein_id=WP_011153736.1

<400>  84

Met Phe Leu Val Leu Ile Glu Thr Ser Gly Asn Gln His Phe Ile Phe 
1               5                   10                  15      


Ser Thr Asn Lys Leu Arg Glu Asn Ile Gly Ala Ser Glu Leu Thr Tyr 
            20                  25                  30          


Leu Ala Thr Thr Glu Ile Leu Phe Gln Gly Val Asp Arg Val Phe Gln 
        35                  40                  45              


Thr Asn Tyr Tyr Asp Gln Trp Ser Asp Thr Asn Ser Leu Asn Phe Leu 
    50                  55                  60                  


Ala Asp Ser Lys Leu Asn Pro Ala Ile Asp Asp Pro Lys Asn Asn Ala 
65                  70                  75                  80  


Asp Ile Glu Ile Leu Leu Ala Thr Ser Gly Lys Ala Ile Ala Leu Val 
                85                  90                  95      


Lys Glu Glu Gly Lys Ala Lys Gln Leu Ile Lys Glu Val Thr Lys Gln 
            100                 105                 110         


Ala Leu Ile Asn Ala Pro Gly Leu Glu Ile Gly Gly Ile Tyr Val Asn 
        115                 120                 125             


Cys Asn Trp Gln Asp Lys Leu Gly Val Ala Lys Ala Val Lys Glu Ala 
    130                 135                 140                 


His Lys Gln Phe Glu Val Asn Arg Ala Lys Arg Ala Gly Ala Asn Gly 
145                 150                 155                 160 


Arg Phe Leu Arg Leu Pro Ile Ala Ala Gly Cys Ser Val Ser Glu Leu 
                165                 170                 175     


Pro Ala Ser Asp Phe Asp Tyr Asn Ala Asp Gly Asp Lys Ile Pro Val 
            180                 185                 190         


Ser Thr Val Ser Lys Val Lys Arg Glu Thr Ala Lys Ser Ala Lys Lys 
        195                 200                 205             


Arg Leu Arg Ser Val Asp Gly Arg Leu Val Asn Asp Leu Ala Gln Leu 
    210                 215                 220                 


Glu Lys Ser Phe Asp Glu Leu Asp Trp Leu Ala Val Val His Ala Asp 
225                 230                 235                 240 


Gly Asn Gly Leu Gly Gln Ile Leu Leu Ser Leu Glu Lys Tyr Ile Gly 
                245                 250                 255     


Glu Gln Thr Asn Arg Asn Tyr Ile Asp Lys Tyr Arg Arg Leu Ser Leu 
            260                 265                 270         


Ala Leu Asp Asn Cys Thr Ile Asn Ala Phe Lys Met Ala Ile Ala Val 
        275                 280                 285             


Phe Lys Glu Asp Ser Lys Lys Ile Asp Leu Pro Ile Val Pro Leu Ile 
    290                 295                 300                 


Leu Gly Gly Asp Asp Leu Thr Val Ile Cys Arg Gly Asp Tyr Ala Leu 
305                 310                 315                 320 


Glu Phe Thr Arg Glu Phe Leu Glu Ala Phe Glu Gly Gln Thr Glu Thr 
                325                 330                 335     


His Asp Asp Ile Lys Val Ile Ala Gln Lys Ala Phe Gly Val Asp Arg 
            340                 345                 350         


Leu Ser Ala Cys Ala Gly Ile Ser Ile Ile Lys Pro His Phe Pro Phe 
        355                 360                 365             


Ser Val Ala Tyr Thr Leu Ala Glu Arg Leu Ile Lys Ser Ala Lys Glu 
    370                 375                 380                 


Val Lys Gln Lys Val Thr Val Thr Asn Ser Ser Pro Ile Thr Pro Phe 
385                 390                 395                 400 


Pro Cys Ser Ala Ile Asp Phe His Ile Leu Tyr Asp Ser Ser Gly Ile 
                405                 410                 415     


Asp Phe Asp Arg Ile Arg Glu Lys Leu Arg Pro Glu Asp Asn Thr Glu 
            420                 425                 430         


Leu Tyr Asn Arg Pro Tyr Val Val Thr Ala Ala Glu Asn Leu Ser Gln 
        435                 440                 445             


Ala Gln Gly Tyr Glu Trp Ser Gln Ala His Ser Leu Gln Thr Leu Ala 
    450                 455                 460                 


Asp Arg Val Ser Tyr Leu Arg Ser Glu Asp Gly Glu Gly Lys Ser Ala 
465                 470                 475                 480 


Leu Pro Ser Ser Gln Ser His Ala Leu Arg Thr Ala Leu Tyr Leu Glu 
                485                 490                 495     


Lys Asn Glu Ala Asp Ala Gln Tyr Ser Leu Ile Ser Gln Arg Tyr Lys 
            500                 505                 510         


Ile Leu Lys Asn Phe Ala Glu Asp Gly Glu Asn Lys Ser Leu Phe His 
        515                 520                 525             


Leu Glu Asn Gly Lys Tyr Val Thr Arg Phe Leu Asp Ala Leu Asp Ala 
    530                 535                 540                 


Lys Asp Phe Phe Ala Asn Ala Asn His Lys Asn Gln Gly Glu 
545                 550                 555             


<210>  85
<211>  367
<212>  PRT
<213>  Synechocystis spp


<220>
<221>  PEPTIDE
<222>  (1)..(367)
<223>  CRISPR-associated endoribonuclease Cas6/protein_id=WP_011153737.1

<400>  85

Met Val Asp Leu Lys Ser Leu Ala Gly Ala Glu Met Val Gly Leu Arg 
1               5                   10                  15      


Trp Gln Leu Arg Phe Asp Arg Pro Cys Arg Leu Glu Ser His Tyr Val 
            20                  25                  30          


Lys Gly Leu His Ala Trp Phe Leu His Gln Val Gln Ala Ile Asp Pro 
        35                  40                  45              


Asp Val Ser Ala Trp Leu His Asp Gly Gln Gly Glu Lys Pro Phe Thr 
    50                  55                  60                  


Ile Ser Arg Leu Ile Gly Pro Thr Leu Trp Gln Glu Gly His Trp His 
65                  70                  75                  80  


Trp Gln Ile Asn Lys Thr Tyr His Trp Gln Leu Asn Leu Leu Ser Gly 
                85                  90                  95      


Ala Leu Ile Glu Ala Leu Gln Pro Trp Leu Ala Arg Leu Pro Asn Lys 
            100                 105                 110         


Ile Val Leu Ala Arg Gln Thr Leu Trp Val Glu Ala Val Asp Cys Tyr 
        115                 120                 125             


Leu Ala Pro His Asn Tyr Gln Gln Leu Trp Pro Gln Gly Ala Leu Pro 
    130                 135                 140                 


Arg Arg Gln Glu Phe Thr Phe Thr Ser Pro Thr Ser Phe Arg Arg Gln 
145                 150                 155                 160 


Gly Asn His Tyr Pro Leu Pro Glu Pro Arg Asn Val Leu Gln Ser Tyr 
                165                 170                 175     


Leu Arg Arg Trp Asn Asp Phe Ser Gly Leu Ala Phe Glu Pro Glu Pro 
            180                 185                 190         


Phe Leu Asp Tyr Trp Val Pro Gln Asn Val Val Ile Asp Arg His Trp 
        195                 200                 205             


Leu Glu Ser Val Lys Thr Thr Ala Gly Lys Gln Gly Ser Val Val Gly 
    210                 215                 220                 


Phe Val Gly Ala Val Ser Leu Val Leu Thr Pro Gln Ala Arg Asn Asp 
225                 230                 235                 240 


Gly Asp Asp Tyr Gly Arg Leu Phe His Ala Leu Cys Arg Tyr Gly Pro 
                245                 250                 255     


Tyr Cys Gly Thr Gly His Lys Thr Thr Phe Gly Leu Gly Gln Thr Met 
            260                 265                 270         


Ala Gly Trp Ala Thr Pro Asp Leu Lys Thr Phe Ala Cys Leu Gln Glu 
        275                 280                 285             


Asp Leu Gln Thr Gln Val Leu Thr Gln Arg Ile Asp Gln Cys Ala Ser 
    290                 295                 300                 


Leu Leu Leu Ala Gln Arg Gln Arg Thr Gly Gly Gln Arg Ala Gln Glu 
305                 310                 315                 320 


Ile Cys His Thr Leu Ala Thr Ile Phe Val Arg Arg Glu Gln Gly Glu 
                325                 330                 335     


Ser Leu Gln Glu Ile Ala Leu Asp Leu Gln Leu Pro Tyr Glu Thr Ala 
            340                 345                 350         


Arg Thr Tyr Ser Lys Arg Ala Lys Arg Ala Leu Ala Asn Val Gln 
        355                 360                 365         


<210>  86
<211>  766
<212>  PRT
<213>  Thioalkalivibrio sp.


<220>
<221>  PEPTIDE
<222>  (1)..(766)
<223>  Rad3-related DNA helicase-like protein: 
       /protein_id=WP_013006550.1

<400>  86

Met Gln Ile Arg Leu Lys Tyr Ser Pro Glu Arg Leu Thr Asp Ile Pro 
1               5                   10                  15      


Ala Thr Gly Gln Ser Arg Phe Phe Arg Glu Arg Leu His Ala Ala Ala 
            20                  25                  30          


His Thr Ala Arg Arg Arg Arg Leu Pro Ala Val Gly Leu Asp Ser Ile 
        35                  40                  45              


Ser Ile Asn Leu Gly Ala Arg Asp Leu Ala Val Leu Ser Gly Leu Arg 
    50                  55                  60                  


Gln Gly Asp Glu Pro Trp Ser Glu Val Leu Ser Glu Leu Leu His Gly 
65                  70                  75                  80  


His Leu Asn Gln Pro Gly Gly Glu Pro Arg Ser Lys Arg Thr Glu Ala 
                85                  90                  95      


Ala Asp Arg Arg Ala Glu Gly Pro Asp Trp Met Arg Pro Glu Gln Gly 
            100                 105                 110         


Arg Phe Tyr Ala Pro Leu Ala Glu Gly Leu Ala Ala Asn Ala Ile Leu 
        115                 120                 125             


Leu Ala Glu Ala Ala Thr Gly Thr Gly Lys Gly Arg Ala Val Ala Gln 
    130                 135                 140                 


Ala Val Glu Asp Ala Leu Ala Ala Gly Arg Glu Arg Val Val Val Cys 
145                 150                 155                 160 


Gly Pro Thr Leu Gly Val Leu Ala Ala Leu Ala Arg Glu Phe Gly Ser 
                165                 170                 175     


Cys Pro Gly Leu Asn Arg Pro Met Gln Phe Phe Leu Gly Ala Ala Gln 
            180                 185                 190         


Phe Phe His Ala Gly Arg Ala Arg Gln Leu Ala Ser Leu Met Gln Ser 
        195                 200                 205             


Gly Ser Asp Pro Glu Thr Gln Ala Ser Gly Ser Ala Leu Leu Gln Trp 
    210                 215                 220                 


Leu Asp Ala Gly Ala Pro Ala Gly Arg Thr Asp Ser Thr Ala Ala Phe 
225                 230                 235                 240 


Ala Ser Val Glu Gly Gln Pro Val Ser His Leu Thr Asp Asp Leu Ala 
                245                 250                 255     


Thr Leu Leu Pro Asp Gly Tyr Gly Val Glu Glu Leu Glu Leu Ser Ala 
            260                 265                 270         


Glu Glu Ile Gly Gly Asp Ala Glu Ser Glu Thr Asp Pro Gly Ile Arg 
        275                 280                 285             


Ala Ala Met Ala Ala Arg Asp Leu Glu Gly Asp Ala Pro Ile Val Phe 
    290                 295                 300                 


Cys Thr His Ala Met Tyr Ala Leu His Ala Arg Met Ile Gly Leu Glu 
305                 310                 315                 320 


Arg Tyr Leu Leu Pro Pro His Glu Val Leu Val Leu Asp Glu Ala His 
                325                 330                 335     


Gln Phe Glu Glu Asn Ala Asn Ala Val Leu Ser Pro Thr Ala Ser Leu 
            340                 345                 350         


Asp Gln Leu Pro Arg Leu Leu Arg Ser Leu Pro Ala Ala Leu Leu Leu 
        355                 360                 365             


Lys Thr Gly Lys Arg Asp Leu Glu Ala Val Glu Glu Val Leu Lys Asp 
    370                 375                 380                 


Leu His Asn Arg Phe Pro Glu Arg Gly Gly Glu Ile Leu Leu Phe Pro 
385                 390                 395                 400 


Gly Asp Asp Arg Tyr Ala Ala Val Gln Val Gln Ala Gly Arg Leu His 
                405                 410                 415     


Gln Ala Val Asp Ala Leu Ile Gly Arg Ala Glu Arg Ala Arg Gln His 
            420                 425                 430         


Thr Ala Asp Pro Gly Leu Leu Ala Leu Leu Lys Arg Thr Arg Ser Ile 
        435                 440                 445             


Leu Arg Ala Ser Gln Arg Glu Arg Ala Leu Leu Gln Leu Ser Ser Ser 
    450                 455                 460                 


Pro Val Arg Gly Tyr Leu Ser Leu Ala Val Gly Gly Gln Gly Leu Arg 
465                 470                 475                 480 


Arg Leu Phe Glu Arg Met Trp Ser Gln Val Asp Ala Ala Val Leu Met 
                485                 490                 495     


Ser Ala Thr Leu Tyr Val Pro Thr Arg Asp Ser Arg Arg Ala Asp Val 
            500                 505                 510         


Ser Asp Thr Gln Gly Trp Tyr Ser Ala Arg His Leu Thr Gln Val Leu 
        515                 520                 525             


Ala Leu Pro Arg Glu Arg Leu Arg Thr Leu Lys Pro Val Arg Pro Asp 
    530                 535                 540                 


Trp Val Arg Gly Asn Val Ile Ala His Ile Glu Arg Asn Pro Glu Arg 
545                 550                 555                 560 


Arg Pro Pro Ser Thr Ser Glu Thr Asp Pro Ala Ile Tyr Ala Ala Leu 
                565                 570                 575     


Val Gln Gln Trp Leu Asp Asp Thr Ala Arg Asp Leu Ala Arg Ile Thr 
            580                 585                 590         


Glu Gly Ala Glu Gln Gly Thr Leu Val Leu Leu Thr Ala Tyr Arg Asp 
        595                 600                 605             


Ile Glu Gly Leu Ser Glu Arg Leu Ala Asp Thr Leu Gly Glu Arg Leu 
    610                 615                 620                 


Ile Ala Gln Gly Pro Gly Ala Arg Leu Ser Ala Leu Arg Glu Ala Phe 
625                 630                 635                 640 


Val Ala Ser Ser Arg Asn Gly Glu Arg Pro Val Trp Leu Ala Thr Gly 
                645                 650                 655     


Ala Ala Trp Thr Gly Ile Asn Leu Thr Ser Glu Gly Leu Ser Gln Val 
            660                 665                 670         


Ser Asp Leu Val Ile Ala Arg Leu Pro Val Gly Leu Asn Arg Ser Ile 
        675                 680                 685             


Ser Gln Ala Ala Arg Asn Arg Gly Arg Ala Asn Phe Glu Ser Lys Ala 
    690                 695                 700                 


Ala Glu Thr Tyr Trp Gln Thr Ala Gln Gly Ile Gly Arg Met Val Arg 
705                 710                 715                 720 


Ser Glu Gln Asp Thr Asp Arg His Leu Trp Val Leu Asp Pro Arg Ala 
                725                 730                 735     


Val Ile Glu Pro Leu Tyr Thr Pro Val Arg Leu Leu Leu Glu Ser Tyr 
            740                 745                 750         


Arg Val Ser Asp Gly Pro Arg Asp Ser Asp Cys Ser Pro Pro 
        755                 760                 765     


<210>  87
<211>  233
<212>  PRT
<213>  Thioalkalivibrio sp.


<220>
<221>  PEPTIDE
<222>  (1)..(233)
<223>  hypothetical protein:   /protein_id=WP_013006551.1

<400>  87

Met Tyr Phe Ala His Thr Val Leu Trp Pro Gly Lys Pro Pro Ala Ala 
1               5                   10                  15      


Tyr Arg Arg Ile Leu Ala Ser Leu Val Pro Asp Glu Gly Glu Phe Gln 
            20                  25                  30          


Ile Pro Pro Glu Ile Phe His Tyr Gly Pro Asp Gly Lys Pro Leu Gln 
        35                  40                  45              


Gly Leu Ser Pro Phe Arg Phe Ser Ser Lys Ser Gly Asp Gly Asp Gln 
    50                  55                  60                  


Thr Gln Leu Val Leu Ser Ala Ile Gly Pro Gln Ala Val Ala Met Leu 
65                  70                  75                  80  


Arg Arg Glu Thr Trp Lys Ile Thr His Leu Leu Ser Glu Ser Lys Gly 
                85                  90                  95      


His Pro Leu Ala Asp Arg Thr His Thr Gly Tyr Cys Glu Leu Arg Val 
            100                 105                 110         


Ala Pro Arg Pro Glu Thr Phe Leu Val Asn His Met Ile Ala Glu Arg 
        115                 120                 125             


His Gln Arg Glu Arg Gly Ala Ser Ser Asp Pro Glu Val Ile Arg Arg 
    130                 135                 140                 


Lys Ile Leu Ala Gly Leu Glu Ala Gln Cys Ala Leu Leu Gly Arg Pro 
145                 150                 155                 160 


Leu Pro Glu Gly Val Glu Glu Ala Ile Tyr Asp Ile Arg Pro Ser Glu 
                165                 170                 175     


Lys Thr Phe Ala Thr Pro Ile Ala Gly Gly Met Val Gly Val Gly Pro 
            180                 185                 190         


His Glu Ile Glu Met Asp Ala Ala Leu Glu Ile Lys Gly Pro Trp His 
        195                 200                 205             


Val Gly Ser Leu Ala Ala Arg Gly Phe Gly Arg Ile Leu Gln Pro Arg 
    210                 215                 220                 


Arg Ala Gln Asp Arg Lys Val Ala Ala 
225                 230             


<210>  88
<211>  243
<212>  PRT
<213>  Thioalkalivibrio sp.


<220>
<221>  PEPTIDE
<222>  (1)..(243)
<223>  hypothetical protein /protein_id=WP_018940624.1

<400>  88

Met Leu Ala Glu Ala Thr Gly Leu Glu Pro Ile Gly Gly Pro Ala Pro 
1               5                   10                  15      


Glu Ala Cys Thr Cys Arg Leu Cys Gly Gly Ala Val Ala Ala Gly Glu 
            20                  25                  30          


Pro Arg Phe Glu Gln Lys Phe Gly Ala Thr Phe Asn Asp Gly Pro Ala 
        35                  40                  45              


Thr Leu Asp Arg Val Gly Asn Trp Ile Cys Gly Trp Cys Gly Pro Phe 
    50                  55                  60                  


Leu Glu Ala Ala Gln Met Thr Gln Met Gln Gly Val Leu Val His Gln 
65                  70                  75                  80  


Ala Glu Gly Glu Arg Gly Gln Ala Trp Arg Val Thr Arg Lys Ala His 
                85                  90                  95      


Ile Arg Trp Ala Phe Glu Gln Asn Phe Glu Gly Pro Leu Val Ile Ala 
            100                 105                 110         


Leu Ala Thr Arg Lys Arg Glu His Leu Ile Trp Gln Ala Pro Val Ser 
        115                 120                 125             


Leu Ser Pro Asp Val Leu Gln Leu Arg Val Gly Arg Asp Thr Leu Leu 
    130                 135                 140                 


Val Arg Arg Pro Val Leu Asp Arg Tyr Arg Glu Ala Ala Thr Asp Glu 
145                 150                 155                 160 


Arg Leu Glu Ser Leu Phe Pro Arg Thr Ala Ala Asp Lys Arg Leu Tyr 
                165                 170                 175     


Arg Leu Gly Gln Gln Leu Glu Gln Ala Ser Met Gly Gly Phe Asp Gly 
            180                 185                 190         


Pro Arg Ala Trp Tyr Ala Asp Leu Pro Glu Asp Leu Val Arg Ala Tyr 
        195                 200                 205             


Glu Ala Leu Gly Pro Gly Glu Leu Trp Phe Ala Gln Tyr Val Leu Thr 
    210                 215                 220                 


Gln Ala Leu Asp Glu Pro Pro Arg Phe Lys Phe Asp Arg Leu Asn Pro 
225                 230                 235                 240 


Pro Lys Asp 
            


<210>  89
<211>  349
<212>  PRT
<213>  Thioalkalivibrio sp.


<220>
<221>  PEPTIDE
<222>  (1)..(349)
<223>  type IV CRISPR-associated protein Csf2 /protein_id=WP_013006553.1

<400>  89

Met Ile Arg Leu Glu Gly Thr Leu Tyr Thr Thr Ser Pro Leu His Ile 
1               5                   10                  15      


Thr Asp Ala Ser Gln Asp Arg Arg Ile Glu Ser Gly Asn Ser Thr Met 
            20                  25                  30          


Pro Val Thr Gly Thr Gln Thr Leu Thr Val Val Ser Arg Asp Pro Asp 
        35                  40                  45              


Ser Gly Glu Thr His Thr Arg Arg Val Pro Val Ile Pro Ser Asn Ser 
    50                  55                  60                  


Ile Arg Gly Arg Ile Arg Arg Ala Gly Ala Asp Val Leu Met Glu Ala 
65                  70                  75                  80  


Leu Lys Ala Lys Gly Glu Asn Leu Thr Leu Pro Ala Tyr His Thr Val 
                85                  90                  95      


Cys Ala Gly Thr Ala Asp Gly Arg Pro Asp Lys Gly Ser Ser Val Ser 
            100                 105                 110         


Leu Ser Ala Leu His Gln Arg Arg Glu His Pro Phe Ile Gly Leu Phe 
        115                 120                 125             


Gly Gly Gly Pro Glu Met Val Glu Ser Arg Phe Leu Thr Asp Thr Ala 
    130                 135                 140                 


Trp Ala Leu Val Pro Glu Thr Val Ala Ser Ile Asp Val Pro Ala Ala 
145                 150                 155                 160 


Cys Glu Asp Ala Val Val Asp Pro Met Gly Arg Glu Lys Arg Leu Pro 
                165                 170                 175     


Leu Thr Gln Val Ile Tyr Phe Arg Arg Met Asp Asp Ile Leu Gln Phe 
            180                 185                 190         


Ser Asp Pro Lys Ala Ala Glu Arg Ile Glu Asp Tyr Glu Thr Ala Ala 
        195                 200                 205             


Gln Glu Trp Leu Asp Asn Gln Arg Thr Arg Ser Asn Gly Asp Glu Glu 
    210                 215                 220                 


Arg Gly Asp Arg Val Gln Gly Trp Asn Ala Thr Glu Ile Val Leu Ala 
225                 230                 235                 240 


Gly Met Pro Phe Ser Phe Arg Ile Gly Thr Thr Thr Ser Ser Ser Glu 
                245                 250                 255     


Val Gln Asp Gly Leu Leu Leu Ala Ala Leu Glu Arg Phe Val Glu Arg 
            260                 265                 270         


Phe Pro Asn Leu Gly Gly Trp Lys Val Lys Gly Phe Gly Arg Tyr Asp 
        275                 280                 285             


Leu Ser Ser Ile Arg Met Ser Cys Asp Gly Glu Asp Ala Gly Leu Val 
    290                 295                 300                 


Phe Thr Arg Asp Gly Gly Gln Leu Arg Leu Asn Arg Asp Asn Pro Ala 
305                 310                 315                 320 


Val Ala Glu Arg Leu Asp Ala Trp Ala Ser Tyr Ala Asn Ser Asp Ala 
                325                 330                 335     


Leu Thr Ala Ala Glu Ile Gln Glu Trp Ala Lys Ala Ala 
            340                 345                 


<210>  90
<211>  218
<212>  PRT
<213>  Thioalkalivibrio sp.


<220>
<221>  PEPTIDE
<222>  (1)..(218)
<223>  hypothetical protein/protein_id=WP_013006554.1

<400>  90

Met Ala Ser Glu Thr Met Glu Pro Leu Arg Ile Thr Gly Arg Met His 
1               5                   10                  15      


Gly Leu Met Ile Glu Pro Glu Arg Pro Ile Ala Leu Asp Gly Ile Leu 
            20                  25                  30          


Ala Trp Ala Ile Val Glu Arg Ala Arg Met Glu Gly Ala Glu Asp Pro 
        35                  40                  45              


Leu Glu Ala Gln Glu Ser Leu Pro Leu Ala Phe Asp Ala Asp Arg Ser 
    50                  55                  60                  


Val Trp Lys Ala Ser Trp Ile Phe Arg Arg Tyr Glu Ser Pro Leu Gln 
65                  70                  75                  80  


Thr Arg Gln Gln Thr Lys Lys Thr Asp Val Pro Ala Leu Leu Asp Gly 
                85                  90                  95      


Arg Asn Ala Gly His Trp Glu Gly Arg Val Asp Ala Ile Ala Thr Gly 
            100                 105                 110         


Thr Gly Met Tyr Lys Gly Ala Val Leu Asp Arg Thr Tyr Arg Gln Ile 
        115                 120                 125             


Ser Glu Val Ser Ala Trp Cys Ile Gly Asn Arg Glu Arg Ile Glu Glu 
    130                 135                 140                 


Leu Leu Gly Met Val Asn Gly Leu Gly Ser Leu Arg Arg Gln Gly Phe 
145                 150                 155                 160 


Gly Arg Ile Ser Gly Trp Ala Val Glu Ser Asp Pro Glu Ala Glu Asn 
                165                 170                 175     


Gln Trp Ser Gln Arg Ala Leu Pro Asn Asn Pro Gly Gly Phe Leu Arg 
            180                 185                 190         


Ser Thr Gly Ala Leu Ser Pro Pro Tyr Trp Arg Gln Asp Arg Val Gln 
        195                 200                 205             


Pro Ile Trp Thr Pro Met Thr Asp Gln Leu 
    210                 215             


<210>  91
<211>  1300
<212>  PRT
<213>  Francisella cf. novicida Fx1


<220>
<221>  PEPTIDE
<222>  (1)..(1300)
<223>  type V CRISPR-associated protein Cpf1: /protein_id=WP_014550095.1

<400>  91

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Val Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Asp Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Arg Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Asn Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Glu Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Lys Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Phe Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu His Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Ile  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Asp Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  92
<211>  1129
<212>  PRT
<213>  Alicyclobacillus acidoterrestris


<220>
<221>  PEPTIDE
<222>  (1)..(1129)
<223>  hypothetical protein /protein_id=WP_021296342.1

<400>  92

Met Ala Val Lys Ser Ile Lys Val Lys Leu Arg Leu Asp Asp Met Pro 
1               5                   10                  15      


Glu Ile Arg Ala Gly Leu Trp Lys Leu His Lys Glu Val Asn Ala Gly 
            20                  25                  30          


Val Arg Tyr Tyr Thr Glu Trp Leu Ser Leu Leu Arg Gln Glu Asn Leu 
        35                  40                  45              


Tyr Arg Arg Ser Pro Asn Gly Asp Gly Glu Gln Glu Cys Asp Lys Thr 
    50                  55                  60                  


Ala Glu Glu Cys Lys Ala Glu Leu Leu Glu Arg Leu Arg Ala Arg Gln 
65                  70                  75                  80  


Val Glu Asn Gly His Arg Gly Pro Ala Gly Ser Asp Asp Glu Leu Leu 
                85                  90                  95      


Gln Leu Ala Arg Gln Leu Tyr Glu Leu Leu Val Pro Gln Ala Ile Gly 
            100                 105                 110         


Ala Lys Gly Asp Ala Gln Gln Ile Ala Arg Lys Phe Leu Ser Pro Leu 
        115                 120                 125             


Ala Asp Lys Asp Ala Val Gly Gly Leu Gly Ile Ala Lys Ala Gly Asn 
    130                 135                 140                 


Lys Pro Arg Trp Val Arg Met Arg Glu Ala Gly Glu Pro Gly Trp Glu 
145                 150                 155                 160 


Glu Glu Lys Glu Lys Ala Glu Thr Arg Lys Ser Ala Asp Arg Thr Ala 
                165                 170                 175     


Asp Val Leu Arg Ala Leu Ala Asp Phe Gly Leu Lys Pro Leu Met Arg 
            180                 185                 190         


Val Tyr Thr Asp Ser Glu Met Ser Ser Val Glu Trp Lys Pro Leu Arg 
        195                 200                 205             


Lys Gly Gln Ala Val Arg Thr Trp Asp Arg Asp Met Phe Gln Gln Ala 
    210                 215                 220                 


Ile Glu Arg Met Met Ser Trp Glu Ser Trp Asn Gln Arg Val Gly Gln 
225                 230                 235                 240 


Glu Tyr Ala Lys Leu Val Glu Gln Lys Asn Arg Phe Glu Gln Lys Asn 
                245                 250                 255     


Phe Val Gly Gln Glu His Leu Val His Leu Val Asn Gln Leu Gln Gln 
            260                 265                 270         


Asp Met Lys Glu Ala Ser Pro Gly Leu Glu Ser Lys Glu Gln Thr Ala 
        275                 280                 285             


His Tyr Val Thr Gly Arg Ala Leu Arg Gly Ser Asp Lys Val Phe Glu 
    290                 295                 300                 


Lys Trp Gly Lys Leu Ala Pro Asp Ala Pro Phe Asp Leu Tyr Asp Ala 
305                 310                 315                 320 


Glu Ile Lys Asn Val Gln Arg Arg Asn Thr Arg Arg Phe Gly Ser His 
                325                 330                 335     


Asp Leu Phe Ala Lys Leu Ala Glu Pro Glu Tyr Gln Ala Leu Trp Arg 
            340                 345                 350         


Glu Asp Ala Ser Phe Leu Thr Arg Tyr Ala Val Tyr Asn Ser Ile Leu 
        355                 360                 365             


Arg Lys Leu Asn His Ala Lys Met Phe Ala Thr Phe Thr Leu Pro Asp 
    370                 375                 380                 


Ala Thr Ala His Pro Ile Trp Thr Arg Phe Asp Lys Leu Gly Gly Asn 
385                 390                 395                 400 


Leu His Gln Tyr Thr Phe Leu Phe Asn Glu Phe Gly Glu Arg Arg His 
                405                 410                 415     


Ala Ile Arg Phe His Lys Leu Leu Lys Val Glu Asn Gly Val Ala Arg 
            420                 425                 430         


Glu Val Asp Asp Val Thr Val Pro Ile Ser Met Ser Glu Gln Leu Asp 
        435                 440                 445             


Asn Leu Leu Pro Arg Asp Pro Asn Glu Pro Ile Ala Leu Tyr Phe Arg 
    450                 455                 460                 


Asp Tyr Gly Ala Glu Gln His Phe Thr Gly Glu Phe Gly Gly Ala Lys 
465                 470                 475                 480 


Ile Gln Cys Arg Arg Asp Gln Leu Ala His Met His Arg Arg Arg Gly 
                485                 490                 495     


Ala Arg Asp Val Tyr Leu Asn Val Ser Val Arg Val Gln Ser Gln Ser 
            500                 505                 510         


Glu Ala Arg Gly Glu Arg Arg Pro Pro Tyr Ala Ala Val Phe Arg Leu 
        515                 520                 525             


Val Gly Asp Asn His Arg Ala Phe Val His Phe Asp Lys Leu Ser Asp 
    530                 535                 540                 


Tyr Leu Ala Glu His Pro Asp Asp Gly Lys Leu Gly Ser Glu Gly Leu 
545                 550                 555                 560 


Leu Ser Gly Leu Arg Val Met Ser Val Asp Leu Gly Leu Arg Thr Ser 
                565                 570                 575     


Ala Ser Ile Ser Val Phe Arg Val Ala Arg Lys Asp Glu Leu Lys Pro 
            580                 585                 590         


Asn Ser Lys Gly Arg Val Pro Phe Phe Phe Pro Ile Lys Gly Asn Asp 
        595                 600                 605             


Asn Leu Val Ala Val His Glu Arg Ser Gln Leu Leu Lys Leu Pro Gly 
    610                 615                 620                 


Glu Thr Glu Ser Lys Asp Leu Arg Ala Ile Arg Glu Glu Arg Gln Arg 
625                 630                 635                 640 


Thr Leu Arg Gln Leu Arg Thr Gln Leu Ala Tyr Leu Arg Leu Leu Val 
                645                 650                 655     


Arg Cys Gly Ser Glu Asp Val Gly Arg Arg Glu Arg Ser Trp Ala Lys 
            660                 665                 670         


Leu Ile Glu Gln Pro Val Asp Ala Ala Asn His Met Thr Pro Asp Trp 
        675                 680                 685             


Arg Glu Ala Phe Glu Asn Glu Leu Gln Lys Leu Lys Ser Leu His Gly 
    690                 695                 700                 


Ile Cys Ser Asp Lys Glu Trp Met Asp Ala Val Tyr Glu Ser Val Arg 
705                 710                 715                 720 


Arg Val Trp Arg His Met Gly Lys Gln Val Arg Asp Trp Arg Lys Asp 
                725                 730                 735     


Val Arg Ser Gly Glu Arg Pro Lys Ile Arg Gly Tyr Ala Lys Asp Val 
            740                 745                 750         


Val Gly Gly Asn Ser Ile Glu Gln Ile Glu Tyr Leu Glu Arg Gln Tyr 
        755                 760                 765             


Lys Phe Leu Lys Ser Trp Ser Phe Phe Gly Lys Val Ser Gly Gln Val 
    770                 775                 780                 


Ile Arg Ala Glu Lys Gly Ser Arg Phe Ala Ile Thr Leu Arg Glu His 
785                 790                 795                 800 


Ile Asp His Ala Lys Glu Asp Arg Leu Lys Lys Leu Ala Asp Arg Ile 
                805                 810                 815     


Ile Met Glu Ala Leu Gly Tyr Val Tyr Ala Leu Asp Glu Arg Gly Lys 
            820                 825                 830         


Gly Lys Trp Val Ala Lys Tyr Pro Pro Cys Gln Leu Ile Leu Leu Glu 
        835                 840                 845             


Glu Leu Ser Glu Tyr Gln Phe Asn Asn Asp Arg Pro Pro Ser Glu Asn 
    850                 855                 860                 


Asn Gln Leu Met Gln Trp Ser His Arg Gly Val Phe Gln Glu Leu Ile 
865                 870                 875                 880 


Asn Gln Ala Gln Val His Asp Leu Leu Val Gly Thr Met Tyr Ala Ala 
                885                 890                 895     


Phe Ser Ser Arg Phe Asp Ala Arg Thr Gly Ala Pro Gly Ile Arg Cys 
            900                 905                 910         


Arg Arg Val Pro Ala Arg Cys Thr Gln Glu His Asn Pro Glu Pro Phe 
        915                 920                 925             


Pro Trp Trp Leu Asn Lys Phe Val Val Glu His Thr Leu Asp Ala Cys 
    930                 935                 940                 


Pro Leu Arg Ala Asp Asp Leu Ile Pro Thr Gly Glu Gly Glu Ile Phe 
945                 950                 955                 960 


Val Ser Pro Phe Ser Ala Glu Glu Gly Asp Phe His Gln Ile His Ala 
                965                 970                 975     


Asp Leu Asn Ala Ala Gln Asn Leu Gln Gln Arg Leu Trp Ser Asp Phe 
            980                 985                 990         


Asp Ile Ser Gln Ile Arg Leu Arg  Cys Asp Trp Gly Glu  Val Asp Gly 
        995                 1000                 1005             


Glu Leu  Val Leu Ile Pro Arg  Leu Thr Gly Lys Arg  Thr Ala Asp 
    1010                 1015                 1020             


Ser Tyr  Ser Asn Lys Val Phe  Tyr Thr Asn Thr Gly  Val Thr Tyr 
    1025                 1030                 1035             


Tyr Glu  Arg Glu Arg Gly Lys  Lys Arg Arg Lys Val  Phe Ala Gln 
    1040                 1045                 1050             


Glu Lys  Leu Ser Glu Glu Glu  Ala Glu Leu Leu Val  Glu Ala Asp 
    1055                 1060                 1065             


Glu Ala  Arg Glu Lys Ser Val  Val Leu Met Arg Asp  Pro Ser Gly 
    1070                 1075                 1080             


Ile Ile  Asn Arg Gly Asn Trp  Thr Arg Gln Lys Glu  Phe Trp Ser 
    1085                 1090                 1095             


Met Val  Asn Gln Arg Ile Glu  Gly Tyr Leu Val Lys  Gln Ile Arg 
    1100                 1105                 1110             


Ser Arg  Val Pro Leu Gln Asp  Ser Ala Cys Glu Asn  Thr Gly Asp 
    1115                 1120                 1125             


Ile 
    


<210>  93
<211>  545
<212>  PRT
<213>  Alicyclobacillus acidoterrestris


<220>
<221>  PEPTIDE
<222>  (1)..(545)
<223>  CRISPR-associated endonuclease Cas1:  /protein_id=WP_021296343.1

<400>  93

Met Arg Thr Phe Ile Ser Phe Asp His Val Gln Gly Leu Phe Glu Lys 
1               5                   10                  15      


Ser Ala Asp Thr Val Glu Gly Ser Gly Gln His Asp Arg Ala Glu Arg 
            20                  25                  30          


Arg Lys Arg Pro Ser Asp Val Gly His Asp Val Trp Asp Ile Ala Pro 
        35                  40                  45              


Gln Ser Leu His Leu Gly Asp Glu Asp Leu Gly Ile Val Gly Lys Leu 
    50                  55                  60                  


Asp Ala Ile Arg Tyr Gln Asp Asp Gly Tyr Trp Glu Pro Val Glu Ala 
65                  70                  75                  80  


Lys His Ser Ser Ala Pro Asn Gly Gly Thr Ser Phe Arg Leu Gly Glu 
                85                  90                  95      


Trp Glu Leu Asp Gly Lys Ala Trp Pro Asn Asp Gln Ile Gln Leu Cys 
            100                 105                 110         


Ala Gln Gly Leu Leu Leu Arg Ala Asn Gly Phe Pro Thr Ile Ala Gly 
        115                 120                 125             


Lys Leu Phe Tyr Arg Gly Asn Arg Gln Thr Val Arg Ile Val Phe Ser 
    130                 135                 140                 


Asp Asp Leu Ile Ala Ala Thr Val Ala Thr Ile Arg Arg Ala His Glu 
145                 150                 155                 160 


Leu Glu Gln Ala Ser Met Pro Ser Pro Leu Leu Asn Ser Asp Lys Cys 
                165                 170                 175     


Phe Arg Cys Ser Leu Asn Gly Val Cys Leu Pro Asp Glu Thr Ile Arg 
            180                 185                 190         


Leu Thr Ser Pro Asp Gly Glu Thr Val Pro Ile Arg Asp Ile Val Pro 
        195                 200                 205             


Ser Arg Asp Asp Leu Gly Thr Val Tyr Val Ser Glu Pro Gly Thr Arg 
    210                 215                 220                 


Val Gly Lys Arg Gly Tyr Glu Leu Thr Ile Thr Ser Lys Asp Gly Met 
225                 230                 235                 240 


Glu Ser Thr Val Pro Leu Lys Asp Val Arg His Ile Ser Leu Phe Gly 
                245                 250                 255     


Asn Val Gln Ile Ser Thr Gln Leu Val His Asp Cys Met Glu Ser Gly 
            260                 265                 270         


Val Thr Ile Ser Tyr Leu Thr Ala Ala Gly Arg Leu Val Gly Met Asn 
        275                 280                 285             


His Asn Leu Ile Ser Lys Asn Val Leu Val Arg Arg Glu Gln Phe Lys 
    290                 295                 300                 


Arg Phe Gly Asp Glu Arg Asp Arg Leu Thr Leu Ala Arg Tyr Ile Val 
305                 310                 315                 320 


Arg Ala Lys Ile Leu Asn Gln Arg Thr Leu Leu Arg Arg Asn Ala His 
                325                 330                 335     


Gly Leu Asp Lys Val Ile Leu Lys Asp Leu Leu Asp His Ala Arg Arg 
            340                 345                 350         


Ser Glu Glu Ala Thr Ser Ile Asp Ser Leu Leu Gly Ile Glu Gly Ile 
        355                 360                 365             


Ala Ala Lys Gln Tyr Met Gln Ala Phe Val Leu Met Leu Lys Val Lys 
    370                 375                 380                 


Gly Val Pro Ala Gly Glu Thr Leu Met Asn Gly Arg Asn Arg Arg Pro 
385                 390                 395                 400 


Pro Lys Asp Pro Val Asn Ala Leu Leu Ser Leu Gly Tyr Ser Leu Leu 
                405                 410                 415     


Gln Arg Asp Met Tyr Ala Ala Leu Ala Ala Val Gly Leu Asp Pro Leu 
            420                 425                 430         


Met Gly Phe Tyr His Arg Ile Glu Thr Gly Arg Pro Ser Leu Val Leu 
        435                 440                 445             


Asp Met Met Glu Pro Phe Arg Ala Ile Ile Ala Asp Ser Val Val Val 
    450                 455                 460                 


Arg Thr Leu Asn Thr Gly Glu Ile Ala Trp Asp Asp Phe Tyr Ile Gly 
465                 470                 475                 480 


Gln Glu Ser Cys Ser Leu Lys Leu Pro Gly Arg Lys Arg Phe Phe Gln 
                485                 490                 495     


Ala Phe Glu Arg Arg Met His Glu Thr Val Thr His Pro Val Phe Gly 
            500                 505                 510         


Tyr Lys Leu Ser Tyr Arg Arg Met Leu Glu Leu Glu Ala Arg Phe Leu 
        515                 520                 525             


Ser Arg Tyr Leu Met Gly Glu Leu Pro Glu Tyr Arg Pro Ile Val Thr 
    530                 535                 540                 


Arg 
545 


<210>  94
<211>  97
<212>  PRT
<213>  Alicyclobacillus acidoterrestris


<220>
<221>  PEPTIDE
<222>  (1)..(97)
<223>  CRISPR-associated endonuclease Cas2:  /protein_id=WP_021296344.1

<400>  94

Met Arg Arg Tyr Val Leu Val Ser Tyr Asp Ile Ser Asp Gln Lys Arg 
1               5                   10                  15      


Trp Arg Arg Val Tyr Lys Ile Val Arg Gly Tyr Gly Met His Val Gln 
            20                  25                  30          


Tyr Ser Val Phe Leu Cys Gln Leu Thr Asp Gln Asp Glu Ala Glu Leu 
        35                  40                  45              


Lys Gln Leu Leu Leu Asp Val Ile His Gln Ser Met Asp Gln Val Ile 
    50                  55                  60                  


Phe Ala Arg Ile Gly Thr Val Gln Ala Lys Ala Ala Glu Arg Asn Met 
65                  70                  75                  80  


Ser Cys Ile Gly Arg Asp Phe Val Pro Leu Asp Leu Lys Gly Leu Val 
                85                  90                  95      


Phe 
    


<210>  95
<211>  1252
<212>  PRT
<213>  Oleiphilus sp


<220>
<221>  PEPTIDE
<222>  (1)..(1252)
<223>  hypothetical protein" /protein_id=KZX85786.1

<400>  95

Met Thr Lys Leu Arg His Arg Gln Lys Lys Leu Thr His Asp Trp Ala 
1               5                   10                  15      


Gly Ser Lys Lys Arg Glu Val Leu Gly Ser Asn Gly Lys Leu Gln Asn 
            20                  25                  30          


Pro Leu Leu Met Pro Val Lys Lys Gly Gln Val Thr Glu Phe Arg Lys 
        35                  40                  45              


Ala Phe Ser Ala Tyr Ala Arg Ala Thr Lys Gly Glu Met Thr Asp Gly 
    50                  55                  60                  


Arg Lys Asn Met Phe Thr His Ser Phe Glu Pro Phe Lys Thr Lys Pro 
65                  70                  75                  80  


Ser Leu His Gln Cys Glu Leu Ala Asp Lys Ala Tyr Gln Ser Leu His 
                85                  90                  95      


Ser Tyr Leu Pro Gly Ser Leu Ala His Phe Leu Leu Ser Ala His Ala 
            100                 105                 110         


Leu Gly Phe Arg Ile Phe Ser Lys Ser Gly Glu Ala Thr Ala Phe Gln 
        115                 120                 125             


Ala Ser Ser Lys Ile Glu Ala Tyr Glu Ser Lys Leu Ala Ser Glu Leu 
    130                 135                 140                 


Ala Cys Val Asp Leu Ser Ile Gln Asn Leu Thr Ile Ser Thr Leu Phe 
145                 150                 155                 160 


Asn Ala Leu Thr Thr Ser Val Arg Gly Lys Gly Glu Glu Thr Ser Ala 
                165                 170                 175     


Asp Pro Leu Ile Ala Arg Phe Tyr Thr Leu Leu Thr Gly Lys Pro Leu 
            180                 185                 190         


Ser Arg Asp Thr Gln Gly Pro Glu Arg Asp Leu Ala Glu Val Ile Ser 
        195                 200                 205             


Arg Lys Ile Ala Ser Ser Phe Gly Thr Trp Lys Glu Met Thr Ala Asn 
    210                 215                 220                 


Pro Leu Gln Ser Leu Gln Phe Phe Glu Glu Glu Leu His Ala Leu Asp 
225                 230                 235                 240 


Ala Asn Val Ser Leu Ser Pro Ala Phe Asp Val Leu Ile Lys Met Asn 
                245                 250                 255     


Asp Leu Gln Gly Asp Leu Lys Asn Arg Thr Ile Val Phe Asp Pro Asp 
            260                 265                 270         


Ala Pro Val Phe Glu Tyr Asn Ala Glu Asp Pro Ala Asp Ile Ile Ile 
        275                 280                 285             


Lys Leu Thr Ala Arg Tyr Ala Lys Glu Ala Val Ile Lys Asn Gln Asn 
    290                 295                 300                 


Val Gly Asn Tyr Val Lys Asn Ala Ile Thr Thr Thr Asn Ala Asn Gly 
305                 310                 315                 320 


Leu Gly Trp Leu Leu Asn Lys Gly Leu Ser Leu Leu Pro Val Ser Thr 
                325                 330                 335     


Asp Asp Glu Leu Leu Glu Phe Ile Gly Val Glu Arg Ser His Pro Ser 
            340                 345                 350         


Cys His Ala Leu Ile Glu Leu Ile Ala Gln Leu Glu Ala Pro Glu Leu 
        355                 360                 365             


Phe Glu Lys Asn Val Phe Ser Asp Thr Arg Ser Glu Val Gln Gly Met 
    370                 375                 380                 


Ile Asp Ser Ala Val Ser Asn His Ile Ala Arg Leu Ser Ser Ser Arg 
385                 390                 395                 400 


Asn Ser Leu Ser Met Asp Ser Glu Glu Leu Glu Arg Leu Ile Lys Ser 
                405                 410                 415     


Phe Gln Ile His Thr Pro His Cys Ser Leu Phe Ile Gly Ala Gln Ser 
            420                 425                 430         


Leu Ser Gln Gln Leu Glu Ser Leu Pro Glu Ala Leu Gln Ser Gly Val 
        435                 440                 445             


Asn Ser Ala Asp Ile Leu Leu Gly Ser Thr Gln Tyr Met Leu Thr Asn 
    450                 455                 460                 


Ser Leu Val Glu Glu Ser Ile Ala Thr Tyr Gln Arg Thr Leu Asn Arg 
465                 470                 475                 480 


Ile Asn Tyr Leu Ser Gly Val Ala Gly Gln Ile Asn Gly Ala Ile Lys 
                485                 490                 495     


Arg Lys Ala Ile Asp Gly Glu Lys Ile His Leu Pro Ala Ala Trp Ser 
            500                 505                 510         


Glu Leu Ile Ser Leu Pro Phe Ile Gly Gln Pro Val Ile Asp Val Glu 
        515                 520                 525             


Ser Asp Leu Ala His Leu Lys Asn Gln Tyr Gln Thr Leu Ser Asn Glu 
    530                 535                 540                 


Phe Asp Thr Leu Ile Ser Ala Leu Gln Lys Asn Phe Asp Leu Asn Phe 
545                 550                 555                 560 


Asn Lys Ala Leu Leu Asn Arg Thr Gln His Phe Glu Ala Met Cys Arg 
                565                 570                 575     


Ser Thr Lys Lys Asn Ala Leu Ser Lys Pro Glu Ile Val Ser Tyr Arg 
            580                 585                 590         


Asp Leu Leu Ala Arg Leu Thr Ser Cys Leu Tyr Arg Gly Ser Leu Val 
        595                 600                 605             


Leu Arg Arg Ala Gly Ile Glu Val Leu Lys Lys His Lys Ile Phe Glu 
    610                 615                 620                 


Ser Asn Ser Glu Leu Arg Glu His Val His Glu Arg Lys His Phe Val 
625                 630                 635                 640 


Phe Val Ser Pro Leu Asp Arg Lys Ala Lys Lys Leu Leu Arg Leu Thr 
                645                 650                 655     


Asp Ser Arg Pro Asp Leu Leu His Val Ile Asp Glu Ile Leu Gln His 
            660                 665                 670         


Asp Asn Leu Glu Asn Lys Asp Arg Glu Ser Leu Trp Leu Val Arg Ser 
        675                 680                 685             


Gly Tyr Leu Leu Ala Gly Leu Pro Asp Gln Leu Ser Ser Ser Phe Ile 
    690                 695                 700                 


Asn Leu Pro Ile Ile Thr Gln Lys Gly Asp Arg Arg Leu Ile Asp Leu 
705                 710                 715                 720 


Ile Gln Tyr Asp Gln Ile Asn Arg Asp Ala Phe Val Met Leu Val Thr 
                725                 730                 735     


Ser Ala Phe Lys Ser Asn Leu Ser Gly Leu Gln Tyr Arg Ala Asn Lys 
            740                 745                 750         


Gln Ser Phe Val Val Thr Arg Thr Leu Ser Pro Tyr Leu Gly Ser Lys 
        755                 760                 765             


Leu Val Tyr Val Pro Lys Asp Lys Asp Trp Leu Val Pro Ser Gln Met 
    770                 775                 780                 


Phe Glu Gly Arg Phe Ala Asp Ile Leu Gln Ser Asp Tyr Met Val Trp 
785                 790                 795                 800 


Lys Asp Ala Gly Arg Leu Cys Val Ile Asp Thr Ala Lys His Leu Ser 
                805                 810                 815     


Asn Ile Lys Lys Ser Val Phe Ser Ser Glu Glu Val Leu Ala Phe Leu 
            820                 825                 830         


Arg Glu Leu Pro His Arg Thr Phe Ile Gln Thr Glu Val Arg Gly Leu 
        835                 840                 845             


Gly Val Asn Val Asp Gly Ile Ala Phe Asn Asn Gly Asp Ile Pro Ser 
    850                 855                 860                 


Leu Lys Thr Phe Ser Asn Cys Val Gln Val Lys Val Ser Arg Thr Asn 
865                 870                 875                 880 


Thr Ser Leu Val Gln Thr Leu Asn Arg Trp Phe Glu Gly Gly Lys Val 
                885                 890                 895     


Ser Pro Pro Ser Ile Gln Phe Glu Arg Ala Tyr Tyr Lys Lys Asp Asp 
            900                 905                 910         


Gln Ile His Glu Asp Ala Ala Lys Arg Lys Ile Arg Phe Gln Met Pro 
        915                 920                 925             


Ala Thr Glu Leu Val His Ala Ser Asp Asp Ala Gly Trp Thr Pro Ser 
    930                 935                 940                 


Tyr Leu Leu Gly Ile Asp Pro Gly Glu Tyr Gly Met Gly Leu Ser Leu 
945                 950                 955                 960 


Val Ser Ile Asn Asn Gly Glu Val Leu Asp Ser Gly Phe Ile His Ile 
                965                 970                 975     


Asn Ser Leu Ile Asn Phe Ala Ser Lys Lys Ser Asn His Gln Thr Lys 
            980                 985                 990         


Val Val Pro Arg Gln Gln Tyr Lys  Ser Pro Tyr Ala Asn  Tyr Leu Glu 
        995                 1000                 1005             


Gln Ser  Lys Asp Ser Ala Ala  Gly Asp Ile Ala His  Ile Leu Asp 
    1010                 1015                 1020             


Arg Leu  Ile Tyr Lys Leu Asn  Ala Leu Pro Val Phe  Glu Ala Leu 
    1025                 1030                 1035             


Ser Gly  Asn Ser Gln Ser Ala  Ala Asp Gln Val Trp  Thr Lys Val 
    1040                 1045                 1050             


Leu Ser  Phe Tyr Thr Trp Gly  Asp Asn Asp Ala Gln  Asn Ser Ile 
    1055                 1060                 1065             


Arg Lys  Gln His Trp Phe Gly  Ala Ser His Trp Asp  Ile Lys Gly 
    1070                 1075                 1080             


Met Leu  Arg Gln Pro Pro Thr  Glu Lys Lys Pro Lys  Pro Tyr Ile 
    1085                 1090                 1095             


Ala Phe  Pro Gly Ser Gln Val  Ser Ser Tyr Gly Asn  Ser Gln Arg 
    1100                 1105                 1110             


Cys Ser  Cys Cys Gly Arg Asn  Pro Ile Glu Gln Leu  Arg Glu Met 
    1115                 1120                 1125             


Ala Lys  Asp Thr Ser Ile Lys  Glu Leu Lys Ile Arg  Asn Ser Glu 
    1130                 1135                 1140             


Ile Gln  Leu Phe Asp Gly Thr  Ile Lys Leu Phe Asn  Pro Asp Pro 
    1145                 1150                 1155             


Ser Thr  Val Ile Glu Arg Arg  Arg His Asn Leu Gly  Pro Ser Arg 
    1160                 1165                 1170             


Ile Pro  Val Ala Asp Arg Thr  Phe Lys Asn Ile Ser  Pro Ser Ser 
    1175                 1180                 1185             


Leu Glu  Phe Lys Glu Leu Ile  Thr Ile Val Ser Arg  Ser Ile Arg 
    1190                 1195                 1200             


His Ser  Pro Glu Phe Ile Ala  Lys Lys Arg Gly Ile  Gly Ser Glu 
    1205                 1210                 1215             


Tyr Phe  Cys Ala Tyr Ser Asp  Cys Asn Ser Ser Leu  Asn Ser Glu 
    1220                 1225                 1230             


Ala Asn  Ala Ala Ala Asn Val  Ala Gln Lys Phe Gln  Lys Gln Leu 
    1235                 1240                 1245             


Phe Phe  Glu Leu 
    1250         


<210>  96
<211>  338
<212>  PRT
<213>  Oleiphilus sp


<220>
<221>  PEPTIDE
<222>  (1)..(338)
<223>  hypothetical protein /protein_id=KZX85787.1

<400>  96

Met Asn Asp Glu Asn Lys Thr Lys Ser His Pro Asn Ser Ile Trp Tyr 
1               5                   10                  15      


Trp Cys Ser Gly Glu Lys Leu Trp Tyr Leu Pro Tyr Ser Gly Thr Pro 
            20                  25                  30          


Lys Arg Thr Ser Lys Ser Val Trp Thr Val Ser Gly Ser Phe Gly Gln 
        35                  40                  45              


Leu Asp Ile Asp Leu Tyr Lys Thr Ser His Ile Leu Phe Tyr Gly Ala 
    50                  55                  60                  


Asn Glu Thr Thr Gly Asp Leu Pro Leu Leu Phe Leu Ser Asp Cys Ala 
65                  70                  75                  80  


Lys His Ser Val Ser Ile Ser Ile His Arg Asn His Val Ser Glu Pro 
                85                  90                  95      


Phe Val Phe Tyr Arg Asn Lys Thr Thr Asp Arg Asp Asp Leu Val Thr 
            100                 105                 110         


Ala Gln Ile Leu His Arg Glu Asn Thr Lys Lys Ser Ala Tyr Ile Ala 
        115                 120                 125             


Arg Thr Ile Ile Arg Leu Gln Ile Lys Gln Arg Gly Tyr Val Ile Pro 
    130                 135                 140                 


Ser Ser Phe Asp Asp Thr Lys Leu Leu Ser Ser Arg Asn Val Asp Glu 
145                 150                 155                 160 


Val Arg Thr Ile Glu Ala Thr Ala Ser Arg Glu Tyr Trp Arg Leu Tyr 
                165                 170                 175     


Phe Lys Lys Leu Gly Leu Glu Gly Leu Gly Arg Arg Asp Asp His Val 
            180                 185                 190         


Val Val Lys Ala Leu Asp Ala Thr Ser His Phe Leu Ser Gly Ile Met 
        195                 200                 205             


Leu Arg Trp Val Leu Ser His Glu Leu Ser Pro Ala His Gly Phe Ile 
    210                 215                 220                 


His Lys Ser Ser Ser Tyr Pro Ser Leu Val Tyr Asp Leu Ile Glu Pro 
225                 230                 235                 240 


Leu Arg Trp Ile Pro Glu Leu Ala Val Phe Gln Ser Tyr Leu Glu Phe 
                245                 250                 255     


Gly Glu His Arg Leu Leu Glu Arg Ser Ile Glu Arg Phe Lys Gln Met 
            260                 265                 270         


Leu Asp Glu Pro Ile His Ser Glu Pro Thr Arg Gln Leu Val Tyr Arg 
        275                 280                 285             


Arg Thr Leu Ile His Gly Gln Val Ile Ala Leu Arg His Tyr Leu Asn 
    290                 295                 300                 


Gly Asn Met Gln Arg Tyr Leu Pro Pro Val Glu Glu Leu Ala Lys Glu 
305                 310                 315                 320 


Arg Gly Arg Lys Arg Ala Val Ser Tyr Thr Leu Pro Gly Gln Ile Trp 
                325                 330                 335     


Lys Lys 
        


<210>  97
<211>  347
<212>  PRT
<213>  Bacterium CG09_39_24


<220>
<221>  PEPTIDE
<222>  (1)..(347)
<223>  CRISPR-associated endonuclease Cas1 /protein_id=OJI08768.1

<400>  97

Met Arg Arg Tyr Phe Ala Lys Arg Lys Gln Phe Ile Trp Leu Pro Tyr 
1               5                   10                  15      


Val Lys Ser Ile Asp Leu Ser Gly Lys Ser Val Lys Phe Ser Tyr Lys 
            20                  25                  30          


Gly Gly Glu Leu Asp Leu Ser Phe Pro Glu Ile His Ser Ile Met Phe 
        35                  40                  45              


Tyr Gly Ser Val Cys Pro Leu Glu Gln Glu Phe Leu Glu Lys Cys Ser 
    50                  55                  60                  


Ala Trp Gly Ile Pro Leu Thr Ile His Arg Arg Asn Met Pro Arg Gly 
65                  70                  75                  80  


Val Trp Ile Val Pro Ser Thr Thr Ser Asn Arg Glu Asp Leu Leu Thr 
                85                  90                  95      


Lys Gln Ile Leu Phe Arg Gln Asn Glu Lys Lys Arg Ala Tyr Ile Thr 
            100                 105                 110         


Lys Arg Leu Ile Tyr Ala Lys Phe Lys Ser Met Glu Trp Leu Ile Pro 
        115                 120                 125             


Ala Pro Thr Gln Glu Leu Gln Gly Leu Ser Ser Val Glu Ser Ile Val 
    130                 135                 140                 


Gly Val Glu Ser Trp His Ala Lys Arg Tyr Trp Glu His Phe Tyr Lys 
145                 150                 155                 160 


Ser Leu Gly Tyr Pro Lys Asp Arg Arg Arg Ser Lys Gly Asn Phe Ile 
                165                 170                 175     


Cys Asn Val Leu Asp Ala Ser Ser Lys Phe Val Ser Gly Ile Ile Leu 
            180                 185                 190         


Arg Trp Val Val Tyr His His Phe Ser Pro Phe His Gly Tyr Thr His 
        195                 200                 205             


Thr Pro Ser Asp Tyr Pro Ser Leu Ile Tyr Asp Leu Met Glu Pro Tyr 
    210                 215                 220                 


Arg Gly Phe Ile Asp Gly Val Ala Phe Asn Thr Ile Lys Glu Ile Gln 
225                 230                 235                 240 


Glu Asn Gly Gly Asp Glu Ser Lys Thr Leu Pro Tyr Thr Met Glu Asn 
                245                 250                 255     


Leu Lys Asp Phe Met Asp Thr Glu Ile Tyr Val Ala Ala Thr Arg Gln 
            260                 265                 270         


Thr Ala Thr Phe Gln Glu Leu Tyr His Gly Leu Ile Leu Gly Leu Arg 
        275                 280                 285             


Ser Tyr Leu Leu Gly Asn Lys Arg Phe Ile Val Pro Phe Pro Gly Lys 
    290                 295                 300                 


Pro Ser Gly Gly Arg Pro Val Lys Ala Gly Tyr Lys Leu Tyr Gly Arg 
305                 310                 315                 320 


Phe Ala Gly Lys Thr Asp Phe Trp Pro Glu Ser Arg Asp Ile Ala Lys 
                325                 330                 335     


Thr Phe Gln Gln Lys Phe Ser Ile Arg Leu Glu 
            340                 345         


<210>  98
<211>  1125
<212>  PRT
<213>  Bacterium CG09_39_24


<220>
<221>  PEPTIDE
<222>  (1)..(1125)
<223>  hypothetical protein:  /protein_id=OJI08769.1

<400>  98

Met Arg Lys Lys Leu Phe Lys Gly Tyr Ile Leu His Asn Lys Arg Leu 
1               5                   10                  15      


Val Tyr Thr Gly Lys Ala Ala Ile Arg Ser Ile Lys Tyr Pro Leu Val 
            20                  25                  30          


Ala Pro Asn Lys Thr Ala Leu Asn Asn Leu Ser Glu Lys Ile Ile Tyr 
        35                  40                  45              


Asp Tyr Glu His Leu Phe Gly Pro Leu Asn Val Ala Ser Tyr Ala Arg 
    50                  55                  60                  


Asn Ser Asn Arg Tyr Ser Leu Val Asp Phe Trp Ile Asp Ser Leu Arg 
65                  70                  75                  80  


Ala Gly Val Ile Trp Gln Ser Lys Ser Thr Ser Leu Ile Asp Leu Ile 
                85                  90                  95      


Ser Lys Leu Glu Gly Ser Lys Ser Pro Ser Glu Lys Ile Phe Glu Gln 
            100                 105                 110         


Ile Asp Phe Glu Leu Lys Asn Lys Leu Asp Lys Glu Gln Phe Lys Asp 
        115                 120                 125             


Ile Ile Leu Leu Asn Thr Gly Ile Arg Ser Ser Ser Asn Val Arg Ser 
    130                 135                 140                 


Leu Arg Gly Arg Phe Leu Lys Cys Phe Lys Glu Glu Phe Arg Asp Thr 
145                 150                 155                 160 


Glu Glu Val Ile Ala Cys Val Asp Lys Trp Ser Lys Asp Leu Ile Val 
                165                 170                 175     


Glu Gly Lys Ser Ile Leu Val Ser Lys Gln Phe Leu Tyr Trp Glu Glu 
            180                 185                 190         


Glu Phe Gly Ile Lys Ile Phe Pro His Phe Lys Asp Asn His Asp Leu 
        195                 200                 205             


Pro Lys Leu Thr Phe Phe Val Glu Pro Ser Leu Glu Phe Ser Pro His 
    210                 215                 220                 


Leu Pro Leu Ala Asn Cys Leu Glu Arg Leu Lys Lys Phe Asp Ile Ser 
225                 230                 235                 240 


Arg Glu Ser Leu Leu Gly Leu Asp Asn Asn Phe Ser Ala Phe Ser Asn 
                245                 250                 255     


Tyr Phe Asn Glu Leu Phe Asn Leu Leu Ser Arg Gly Glu Ile Lys Lys 
            260                 265                 270         


Ile Val Thr Ala Val Leu Ala Val Ser Lys Ser Trp Glu Asn Glu Pro 
        275                 280                 285             


Glu Leu Glu Lys Arg Leu His Phe Leu Ser Glu Lys Ala Lys Leu Leu 
    290                 295                 300                 


Gly Tyr Pro Lys Leu Thr Ser Ser Trp Ala Asp Tyr Arg Met Ile Ile 
305                 310                 315                 320 


Gly Gly Lys Ile Lys Ser Trp His Ser Asn Tyr Thr Glu Gln Leu Ile 
                325                 330                 335     


Lys Val Arg Glu Asp Leu Lys Lys His Gln Ile Ala Leu Asp Lys Leu 
            340                 345                 350         


Gln Glu Asp Leu Lys Lys Val Val Asp Ser Ser Leu Arg Glu Gln Ile 
        355                 360                 365             


Glu Ala Gln Arg Glu Ala Leu Leu Pro Leu Leu Asp Thr Met Leu Lys 
    370                 375                 380                 


Glu Lys Asp Phe Ser Asp Asp Leu Glu Leu Tyr Arg Phe Ile Leu Ser 
385                 390                 395                 400 


Asp Phe Lys Ser Leu Leu Asn Gly Ser Tyr Gln Arg Tyr Ile Gln Thr 
                405                 410                 415     


Glu Glu Glu Arg Lys Glu Asp Arg Asp Val Thr Lys Lys Tyr Lys Asp 
            420                 425                 430         


Leu Tyr Ser Asn Leu Arg Asn Ile Pro Arg Phe Phe Gly Glu Ser Lys 
        435                 440                 445             


Lys Glu Gln Phe Asn Lys Phe Ile Asn Lys Ser Leu Pro Thr Ile Asp 
    450                 455                 460                 


Val Gly Leu Lys Ile Leu Glu Asp Ile Arg Asn Ala Leu Glu Thr Val 
465                 470                 475                 480 


Ser Val Arg Lys Pro Pro Ser Ile Thr Glu Glu Tyr Val Thr Lys Gln 
                485                 490                 495     


Leu Glu Lys Leu Ser Arg Lys Tyr Lys Ile Asn Ala Phe Asn Ser Asn 
            500                 505                 510         


Arg Phe Lys Gln Ile Thr Glu Gln Val Leu Arg Lys Tyr Asn Asn Gly 
        515                 520                 525             


Glu Leu Pro Lys Ile Ser Glu Val Phe Tyr Arg Tyr Pro Arg Glu Ser 
    530                 535                 540                 


His Val Ala Ile Arg Ile Leu Pro Val Lys Ile Ser Asn Pro Arg Lys 
545                 550                 555                 560 


Asp Ile Ser Tyr Leu Leu Asp Lys Tyr Gln Ile Ser Pro Asp Trp Lys 
                565                 570                 575     


Asn Ser Asn Pro Gly Glu Val Val Asp Leu Ile Glu Ile Tyr Lys Leu 
            580                 585                 590         


Thr Leu Gly Trp Leu Leu Ser Cys Asn Lys Asp Phe Ser Met Asp Phe 
        595                 600                 605             


Ser Ser Tyr Asp Leu Lys Leu Phe Pro Glu Ala Ala Ser Leu Ile Lys 
    610                 615                 620                 


Asn Phe Gly Ser Cys Leu Ser Gly Tyr Tyr Leu Ser Lys Met Ile Phe 
625                 630                 635                 640 


Asn Cys Ile Thr Ser Glu Ile Lys Gly Met Ile Thr Leu Tyr Thr Arg 
                645                 650                 655     


Asp Lys Phe Val Val Arg Tyr Val Thr Gln Met Ile Gly Ser Asn Gln 
            660                 665                 670         


Lys Phe Pro Leu Leu Cys Leu Val Gly Glu Lys Gln Thr Lys Asn Phe 
        675                 680                 685             


Ser Arg Asn Trp Gly Val Leu Ile Glu Glu Lys Gly Asp Leu Gly Glu 
    690                 695                 700                 


Glu Lys Asn Gln Glu Lys Cys Leu Ile Phe Lys Asp Lys Thr Asp Phe 
705                 710                 715                 720 


Ala Lys Ala Lys Glu Val Glu Ile Phe Lys Asn Asn Ile Trp Arg Ile 
                725                 730                 735     


Arg Thr Ser Lys Tyr Gln Ile Gln Phe Leu Asn Arg Leu Phe Lys Lys 
            740                 745                 750         


Thr Lys Glu Trp Asp Leu Met Asn Leu Val Leu Ser Glu Pro Ser Leu 
        755                 760                 765             


Val Leu Glu Glu Glu Trp Gly Val Ser Trp Asp Lys Asp Lys Leu Leu 
    770                 775                 780                 


Pro Leu Leu Lys Lys Glu Lys Ser Cys Glu Glu Arg Leu Tyr Tyr Ser 
785                 790                 795                 800 


Leu Pro Leu Asn Leu Val Pro Ala Thr Asp Tyr Lys Glu Gln Ser Ala 
                805                 810                 815     


Glu Ile Glu Gln Arg Asn Thr Tyr Leu Gly Leu Asp Val Gly Glu Phe 
            820                 825                 830         


Gly Val Ala Tyr Ala Val Val Arg Ile Val Arg Asp Arg Ile Glu Leu 
        835                 840                 845             


Leu Ser Trp Gly Phe Leu Lys Asp Pro Ala Leu Arg Lys Ile Arg Glu 
    850                 855                 860                 


Arg Val Gln Asp Met Lys Lys Lys Gln Val Met Ala Val Phe Ser Ser 
865                 870                 875                 880 


Ser Ser Thr Ala Val Ala Arg Val Arg Glu Met Ala Ile His Ser Leu 
                885                 890                 895     


Arg Asn Gln Ile His Ser Ile Ala Leu Ala Tyr Lys Ala Lys Ile Ile 
            900                 905                 910         


Tyr Glu Ile Ser Ile Ser Asn Phe Glu Thr Gly Gly Asn Arg Met Ala 
        915                 920                 925             


Lys Ile Tyr Arg Ser Ile Lys Val Ser Asp Val Tyr Arg Glu Ser Gly 
    930                 935                 940                 


Ala Asp Thr Leu Val Ser Glu Met Ile Trp Gly Lys Lys Asn Lys Gln 
945                 950                 955                 960 


Met Gly Asn His Ile Ser Ser Tyr Ala Thr Ser Tyr Thr Cys Cys Asn 
                965                 970                 975     


Cys Ala Arg Thr Pro Phe Glu Leu Val Ile Asp Asn Asp Lys Glu Tyr 
            980                 985                 990         


Glu Lys Gly Gly Asp Glu Phe Ile  Phe Asn Val Gly Asp  Glu Lys Lys 
        995                 1000                 1005             


Val Arg  Gly Phe Leu Gln Lys  Ser Leu Leu Gly Lys  Thr Ile Lys 
    1010                 1015                 1020             


Gly Lys  Glu Val Leu Lys Ser  Ile Lys Glu Tyr Ala  Arg Pro Pro 
    1025                 1030                 1035             


Ile Arg  Glu Val Leu Leu Glu  Gly Glu Asp Val Glu  Gln Leu Leu 
    1040                 1045                 1050             


Lys Arg  Arg Gly Asn Ser Tyr  Ile Tyr Arg Cys Pro  Phe Cys Gly 
    1055                 1060                 1065             


Tyr Lys  Thr Asp Ala Asp Ile  Gln Ala Ala Leu Asn  Ile Ala Cys 
    1070                 1075                 1080             


Arg Gly  Tyr Ile Ser Asp Asn  Ala Lys Asp Ala Val  Lys Glu Gly 
    1085                 1090                 1095             


Glu Arg  Lys Leu Asp Tyr Ile  Leu Glu Val Arg Lys  Leu Trp Glu 
    1100                 1105                 1110             


Lys Asn  Gly Ala Val Leu Arg  Ser Ala Lys Phe Leu  
    1115                 1120                 1125 


<210>  99
<211>  986
<212>  PRT
<213>  Deltaproteobacteria bacterium


<220>
<221>  PEPTIDE
<222>  (1)..(986)
<223>  hypothetical protein  /protein_id=OGP07438.1

<400>  99

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr 
            820                 825                 830         


Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly 
        835                 840                 845             


Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser 
865                 870                 875                 880 


Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser 
                885                 890                 895     


Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys 
        915                 920                 925             


Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  100
<211>  194
<212>  PRT
<213>  Deltaproteobacteria bacterium


<220>
<221>  PEPTIDE
<222>  (1)..(194)
<223>  CRISPR-associated protein Cas4:  /protein_id=OGP07439.1

<400>  100

Met Glu Ala Gln Arg Leu Ile Leu Pro Ile Ser Thr Val Met Glu Ser 
1               5                   10                  15      


Ile Tyr Cys Pro Arg Asn Ala Trp Tyr Ala Phe Val Gly Glu Arg Arg 
            20                  25                  30          


Asn Met Ala Lys Ser Val His Phe Thr Glu Ala Val His Ala His Arg 
        35                  40                  45              


Ala Val Asp Glu Ser Thr Gln Arg Ile Arg Thr Asp Cys Lys Gln Ile 
    50                  55                  60                  


Thr Gly Met Tyr Ile Tyr Ser Asn Lys Leu Gly Leu Thr Gly Arg Ala 
65                  70                  75                  80  


Asp Thr Val Glu Trp Leu Tyr Gly Ile Pro Ile Pro Val Glu Thr Lys 
                85                  90                  95      


Thr Gly Ala Ile Arg Asp Phe Glu Asn Phe Arg Val Gln Ile Ala Leu 
            100                 105                 110         


Gln Ala Leu Cys Leu Glu Glu Met Phe Asn Val Asn Ile Pro Tyr Gly 
        115                 120                 125             


Glu Ile Phe Phe Cys Glu Thr Met Arg Arg His Glu Ile Ala Val Asp 
    130                 135                 140                 


Glu Asp Leu Arg Thr His Ser Thr Ala Ile Val Val Glu Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Leu Ser Phe Asp Ile Asn Arg Phe Gln Arg Val Asn Asp His 
                165                 170                 175     


Arg Cys Pro Lys Cys Gln Tyr Leu Glu Ser Cys Leu Pro Pro Ser Leu 
            180                 185                 190         


Glu Leu 
        


<210>  101
<211>  328
<212>  PRT
<213>  Deltaproteobacteria bacterium


<220>
<221>  PEPTIDE
<222>  (1)..(328)
<223>  CRISPR-associated endonuclease Cas1:  /protein_id=OGP07440.1

<400>  101

Met Thr Ala Ile Thr Asp Arg Ile Thr Leu Tyr Ile Thr Ala Asp Glu 
1               5                   10                  15      


Ser Ser Ile Ser Arg Arg Gly Asp Ala Phe Leu Ile Gln Lys Ala Gly 
            20                  25                  30          


Glu Glu Lys Gly Gln Lys Ile Pro Ala Met Lys Val Lys Asp Ile Val 
        35                  40                  45              


Val Val Gly His Val Thr Leu Asp Ser Arg Leu Ile Gly Leu Cys Arg 
    50                  55                  60                  


Glu Glu Ser Ile Pro Ile His Phe Leu Ser Gly Arg Trp Glu Tyr Gln 
65                  70                  75                  80  


Gly Ser Leu Gln Phe Glu Pro Val Lys Asn Leu Phe Ile Arg Arg Ala 
                85                  90                  95      


Gln Ile Lys Lys His Phe Asp Pro Glu Lys Lys Leu Asp Ile Ser Lys 
            100                 105                 110         


Lys Ile Val Gly Gly Lys Ile Arg Asn Gln Gln Ala Met Leu Asp Lys 
        115                 120                 125             


Tyr Arg Lys Asn Leu Lys Leu Ala Cys Pro Gln Ile Asp Ser Val Gly 
    130                 135                 140                 


Asp Met Glu Thr Leu Arg Gly Ile Glu Gly Val Val Ala Lys Glu Tyr 
145                 150                 155                 160 


Tyr Gly Phe Tyr Pro Ala Ile Ile Lys Asn Ser Glu Phe Thr Phe Thr 
                165                 170                 175     


Arg Arg Thr Lys Arg Pro Pro Glu Asp Glu Ile Asn Ala Leu Leu Ser 
            180                 185                 190         


Leu Leu Tyr Thr Leu Ile Phe Asn Glu Ile His Ser Thr Ala Leu Leu 
        195                 200                 205             


Val Gly Leu Asp Pro Ala Phe Gly Tyr Leu His Asp Val Tyr Tyr Gly 
    210                 215                 220                 


Arg Pro Ser Leu Ile Cys Asp Leu Leu Glu Glu Trp Arg Pro Leu Ala 
225                 230                 235                 240 


Asp Arg Phe Val Leu Asn Met Ile Asn Arg Lys Glu Val Thr Pro Glu 
                245                 250                 255     


Asp Phe Arg Lys Glu Thr Asp Gln Lys Gly Val Trp Leu Ser Lys Asp 
            260                 265                 270         


Gly Tyr Pro Lys Val Ile Lys Lys Trp His Gln Phe Phe Lys Met Asp 
        275                 280                 285             


Glu Gln Asn Thr Ser Ile Leu Ser Arg Pro Ile Thr Tyr Gln His Ala 
    290                 295                 300                 


Ile Glu Arg Gln Val Arg Thr Phe Ser Gln Tyr Leu Met Asp Asp Lys 
305                 310                 315                 320 


Asp Asn Tyr Lys Thr Ile Glu Leu 
                325             


<210>  102
<211>  92
<212>  PRT
<213>  Deltaproteobacteria bacterium


<220>
<221>  PEPTIDE
<222>  (1)..(92)
<223>  CRISPR-associated endonuclease Cas2: /protein_id=OGP07441.1

<400>  102

Met Arg His Leu Ile Cys Tyr Asp Ile Glu Glu Asp Lys Val Arg Ala 
1               5                   10                  15      


Arg Leu Val Lys Leu Leu Glu Ala Tyr Gly Val Arg Ile Gln Tyr Ser 
            20                  25                  30          


Val Phe Glu Phe Asn Leu Ser Lys Ala Arg Trp Thr Asp Leu Lys Leu 
        35                  40                  45              


Asn Leu Lys Glu Lys Gly Phe Leu Asp Gly Ser Ile Ser Ile Val Ile 
    50                  55                  60                  


Tyr Pro Leu Ser Ala Glu Ala Tyr Glu Leu Val Glu Arg Tyr Gly Ala 
65                  70                  75                  80  


Ala Ser Ile Trp Asp Glu Gly Asp Met Val Phe Asp 
                85                  90          


<210>  103
<211>  1389
<212>  PRT
<213>  Leptotrichia shahii DSM 19757


<220>
<221>  PEPTIDE
<222>  (1)..(1389)
<223>  type VI-A CRISPR-associated effector C2c2:  
       /protein_id=WP_018451595.1

<400>  103

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Arg Asp Lys 
1               5                   10                  15      


Lys Asp Phe Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Lys Tyr Ile Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Ile Leu Lys Glu Phe Thr Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Lys Glu Gly Ile Ile Arg Ile Glu Asn Asn 
                85                  90                  95      


Asp Asp Phe Leu Glu Thr Glu Glu Val Val Leu Tyr Ile Glu Ala Tyr 
            100                 105                 110         


Gly Lys Ser Glu Lys Leu Lys Ala Leu Gly Ile Thr Lys Lys Lys Ile 
        115                 120                 125             


Ile Asp Glu Ala Ile Arg Gln Gly Ile Thr Lys Asp Asp Lys Lys Ile 
    130                 135                 140                 


Glu Ile Lys Arg Gln Glu Asn Glu Glu Glu Ile Glu Ile Asp Ile Arg 
145                 150                 155                 160 


Asp Glu Tyr Thr Asn Lys Thr Leu Asn Asp Cys Ser Ile Ile Leu Arg 
                165                 170                 175     


Ile Ile Glu Asn Asp Glu Leu Glu Thr Lys Lys Ser Ile Tyr Glu Ile 
            180                 185                 190         


Phe Lys Asn Ile Asn Met Ser Leu Tyr Lys Ile Ile Glu Lys Ile Ile 
        195                 200                 205             


Glu Asn Glu Thr Glu Lys Val Phe Glu Asn Arg Tyr Tyr Glu Glu His 
    210                 215                 220                 


Leu Arg Glu Lys Leu Leu Lys Asp Asp Lys Ile Asp Val Ile Leu Thr 
225                 230                 235                 240 


Asn Phe Met Glu Ile Arg Glu Lys Ile Lys Ser Asn Leu Glu Ile Leu 
                245                 250                 255     


Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser 
            260                 265                 270         


Lys Asn Lys Lys Met Leu Val Glu Lys Ile Leu Asn Ile Asn Val Asp 
        275                 280                 285             


Leu Thr Val Glu Asp Ile Ala Asp Phe Val Ile Lys Glu Leu Glu Phe 
    290                 295                 300                 


Trp Asn Ile Thr Lys Arg Ile Glu Lys Val Lys Lys Val Asn Asn Glu 
305                 310                 315                 320 


Phe Leu Glu Lys Arg Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu 
                325                 330                 335     


Leu Asp Lys His Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp 
            340                 345                 350         


Lys Ile Val Lys Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys 
        355                 360                 365             


Glu Lys Ile Glu Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Ile 
    370                 375                 380                 


Lys Lys Leu Glu Lys Glu Leu Lys Lys Gly Asn Cys Asp Thr Glu Ile 
385                 390                 395                 400 


Phe Gly Ile Phe Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys 
                405                 410                 415     


Phe Ser Lys Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr 
            420                 425                 430         


Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Val Asn Glu Gln Lys 
        435                 440                 445             


Val Arg Leu Lys Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn 
    450                 455                 460                 


Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr 
465                 470                 475                 480 


Leu Glu His Ile Met Tyr Leu Gly Lys Leu Arg His Asn Asp Ile Asp 
                485                 490                 495     


Met Thr Thr Val Asn Thr Asp Asp Phe Ser Arg Leu His Ala Lys Glu 
            500                 505                 510         


Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu 
        515                 520                 525             


Leu Asn Lys Ile Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile 
    530                 535                 540                 


Asp Phe Phe Gly Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys 
545                 550                 555                 560 


Ile Leu Asn Ser Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp 
                565                 570                 575     


Asn Lys Asn Asn Ile Thr Asn Asn Phe Ile Arg Lys Phe Thr Lys Ile 
            580                 585                 590         


Gly Thr Asn Glu Arg Asn Arg Ile Leu His Ala Ile Ser Lys Glu Arg 
        595                 600                 605             


Asp Leu Gln Gly Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile 
    610                 615                 620                 


Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu 
625                 630                 635                 640 


Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn Asp 
                645                 650                 655     


Ile Lys Ile Ser Glu Glu Asn Asn Asn Asp Ile Lys Tyr Leu Pro Ser 
            660                 665                 670         


Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn Asn Pro 
        675                 680                 685             


Lys Asn Glu Pro Phe Asp Thr Ile Glu Thr Glu Lys Ile Val Leu Asn 
    690                 695                 700                 


Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu 
705                 710                 715                 720 


Asp Asp Leu Glu Glu Asn Glu Ser Lys Asn Ile Phe Leu Gln Glu Leu 
                725                 730                 735     


Lys Lys Thr Leu Gly Asn Ile Asp Glu Ile Asp Glu Asn Ile Ile Glu 
            740                 745                 750         


Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys 
        755                 760                 765             


Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu Cys Tyr Ile Gly Tyr 
    770                 775                 780                 


Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp Phe Ser Asp Phe Lys Met 
785                 790                 795                 800 


Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Asp Ile Asn Asp Asn Lys 
                805                 810                 815     


Thr Tyr Glu Arg Ile Thr Val Lys Thr Ser Asp Lys Thr Ile Val Ile 
            820                 825                 830         


Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser 
        835                 840                 845             


Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val 
    850                 855                 860                 


Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile Asp Ile Leu Asp Glu 
865                 870                 875                 880 


Ile Met Gln Leu Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp 
                885                 890                 895     


Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys 
            900                 905                 910         


Asp Phe Asp Asp Phe Lys Ile Gln Thr Lys Lys Glu Ile Phe Asn Asn 
        915                 920                 925             


Tyr Tyr Glu Asp Ile Lys Asn Asn Ile Leu Thr Glu Phe Lys Asp Asp 
    930                 935                 940                 


Ile Asn Gly Cys Asp Val Leu Glu Lys Lys Leu Glu Lys Ile Val Ile 
945                 950                 955                 960 


Phe Asp Asp Glu Thr Lys Phe Glu Ile Asp Lys Lys Ser Asn Ile Leu 
                965                 970                 975     


Gln Asp Glu Gln Arg Lys Leu Ser Asn Ile Asn Lys Lys Asp Leu Lys 
            980                 985                 990         


Lys Lys Val Asp Gln Tyr Ile Lys  Asp Lys Asp Gln Glu  Ile Lys Ser 
        995                 1000                 1005             


Lys Ile  Leu Cys Arg Ile Ile  Phe Asn Ser Asp Phe  Leu Lys Lys 
    1010                 1015                 1020             


Tyr Lys  Lys Glu Ile Asp Asn  Leu Ile Glu Asp Met  Glu Ser Glu 
    1025                 1030                 1035             


Asn Glu  Asn Lys Phe Gln Glu  Ile Tyr Tyr Pro Lys  Glu Arg Lys 
    1040                 1045                 1050             


Asn Glu  Leu Tyr Ile Tyr Lys  Lys Asn Leu Phe Leu  Asn Ile Gly 
    1055                 1060                 1065             


Asn Pro  Asn Phe Asp Lys Ile  Tyr Gly Leu Ile Ser  Asn Asp Ile 
    1070                 1075                 1080             


Lys Met  Ala Asp Ala Lys Phe  Leu Phe Asn Ile Asp  Gly Lys Asn 
    1085                 1090                 1095             


Ile Arg  Lys Asn Lys Ile Ser  Glu Ile Asp Ala Ile  Leu Lys Asn 
    1100                 1105                 1110             


Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Lys Glu Tyr  Lys Glu Lys 
    1115                 1120                 1125             


Tyr Ile  Lys Lys Leu Lys Glu  Asn Asp Asp Phe Phe  Ala Lys Asn 
    1130                 1135                 1140             


Ile Gln  Asn Lys Asn Tyr Lys  Ser Phe Glu Lys Asp  Tyr Asn Arg 
    1145                 1150                 1155             


Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu Val Glu  Phe Asn Tyr 
    1160                 1165                 1170             


Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp Ile Asn  Trp Lys Leu 
    1175                 1180                 1185             


Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp Met His  Tyr Ile Val 
    1190                 1195                 1200             


Asn Gly  Leu Arg Glu Leu Gly  Ile Ile Lys Leu Ser  Gly Tyr Asn 
    1205                 1210                 1215             


Thr Gly  Ile Ser Arg Ala Tyr  Pro Lys Arg Asn Gly  Ser Asp Gly 
    1220                 1225                 1230             


Phe Tyr  Thr Thr Thr Ala Tyr  Tyr Lys Phe Phe Asp  Glu Glu Ser 
    1235                 1240                 1245             


Tyr Lys  Lys Phe Glu Lys Ile  Cys Tyr Gly Phe Gly  Ile Asp Leu 
    1250                 1255                 1260             


Ser Glu  Asn Ser Glu Ile Asn  Lys Pro Glu Asn Glu  Ser Ile Arg 
    1265                 1270                 1275             


Asn Tyr  Ile Ser His Phe Tyr  Ile Val Arg Asn Pro  Phe Ala Asp 
    1280                 1285                 1290             


Tyr Ser  Ile Ala Glu Gln Ile  Asp Arg Val Ser Asn  Leu Leu Ser 
    1295                 1300                 1305             


Tyr Ser  Thr Arg Tyr Asn Asn  Ser Thr Tyr Ala Ser  Val Phe Glu 
    1310                 1315                 1320             


Val Phe  Lys Lys Asp Val Asn  Leu Asp Tyr Asp Glu  Leu Lys Lys 
    1325                 1330                 1335             


Lys Phe  Lys Leu Ile Gly Asn  Asn Asp Ile Leu Glu  Arg Leu Met 
    1340                 1345                 1350             


Lys Pro  Lys Lys Val Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser 
    1355                 1360                 1365             


Asp Tyr  Ile Lys Asn Leu Ile  Ile Glu Leu Leu Thr  Lys Ile Glu 
    1370                 1375                 1380             


Asn Thr  Asn Asp Thr Leu 
    1385                 


<210>  104
<211>  1127
<212>  PRT
<213>  Prevotella buccae


<220>
<221>  PEPTIDE
<222>  (1)..(1127)
<223>  hypothetical protein:  /protein_id=WP_004343973.1

<400>  104

Met Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Met Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asn Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Ala His Asn Asn Leu Phe Pro Ser Leu Gln Thr Asp Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Arg Arg Leu Gln Asn 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Lys Gly Arg Gln Lys Asp Met Gly Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Arg Leu Lys Pro Lys Lys Arg Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Phe Ser Phe Ala Glu Thr Thr Asp Leu Asn 
            980                 985                 990         


Leu Glu Glu His Pro Ile Ser Lys  Leu Ser Val Asp Leu  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  105
<211>  177
<212>  PRT
<213>  Prevotella buccae


<220>
<221>  PEPTIDE
<222>  (1)..(177)
<223>  hypothetical protein /protein_id=WP_004343974.1

<400>  105

Met Asp Tyr Met Glu Leu Ala Lys Glu Ala Phe Ser Ile Ile Cys Thr 
1               5                   10                  15      


Phe Ile Ala Ala Tyr Val Ala Tyr Tyr Tyr Ala Ile Lys Gln Leu His 
            20                  25                  30          


Gln Lys Ser Val Glu Asn Ile Glu Tyr Ala Lys Tyr Gln Ala Val Leu 
        35                  40                  45              


Gln Ala His Lys Ser Leu Tyr Lys Leu Leu Arg Phe Thr Thr Asn Thr 
    50                  55                  60                  


Glu Asn Glu Asp Ser Ile Leu Ile Trp Glu Lys Thr Lys Asp Gly Lys 
65                  70                  75                  80  


Gln Glu Ala Thr Tyr Tyr Phe Arg Lys Glu Asn Ile Arg Lys Phe Ile 
                85                  90                  95      


Lys Glu Leu Ser Lys Glu Ile Tyr Asn Glu Gly Cys Gly Ile Phe Met 
            100                 105                 110         


Ser Lys Glu Ala Leu Ser Leu Ile Ser Glu Tyr Arg Asn Ile Val Tyr 
        115                 120                 125             


Gly Phe Met Leu Ser Ala Gln Asn Asn Pro Gln Glu Thr Ile Arg Ile 
    130                 135                 140                 


Thr Asn Arg Glu Ser Val Glu Arg Met Lys Lys Ile His Gln Asn Leu 
145                 150                 155                 160 


Ser Ile Glu Ile Arg Gln Ala Ile Asn Leu Lys Lys Arg Asp Leu Arg 
                165                 170                 175     


Phe 
    


<210>  106
<211>  1224
<212>  PRT
<213>  Bergeyella zoohelcum


<220>
<221>  PEPTIDE
<222>  (1)..(1224)
<223>  hypothetical protein  /protein_id=EKB54193.1

<400>  106

Met Glu Asn Lys Thr Ser Leu Gly Asn Asn Ile Tyr Tyr Asn Pro Phe 
1               5                   10                  15      


Lys Pro Gln Asp Lys Ser Tyr Phe Ala Gly Tyr Phe Asn Ala Ala Met 
            20                  25                  30          


Glu Asn Thr Asp Ser Val Phe Arg Glu Leu Gly Lys Arg Leu Lys Gly 
        35                  40                  45              


Lys Glu Tyr Thr Ser Glu Asn Phe Phe Asp Ala Ile Phe Lys Glu Asn 
    50                  55                  60                  


Ile Ser Leu Val Glu Tyr Glu Arg Tyr Val Lys Leu Leu Ser Asp Tyr 
65                  70                  75                  80  


Phe Pro Met Ala Arg Leu Leu Asp Lys Lys Glu Val Pro Ile Lys Glu 
                85                  90                  95      


Arg Lys Glu Asn Phe Lys Lys Asn Phe Lys Gly Ile Ile Lys Ala Val 
            100                 105                 110         


Arg Asp Leu Arg Asn Phe Tyr Thr His Lys Glu His Gly Glu Val Glu 
        115                 120                 125             


Ile Thr Asp Glu Ile Phe Gly Val Leu Asp Glu Met Leu Lys Ser Thr 
    130                 135                 140                 


Val Leu Thr Val Lys Lys Lys Lys Val Lys Thr Asp Lys Thr Lys Glu 
145                 150                 155                 160 


Ile Leu Lys Lys Ser Ile Glu Lys Gln Leu Asp Ile Leu Cys Gln Lys 
                165                 170                 175     


Lys Leu Glu Tyr Leu Arg Asp Thr Ala Arg Lys Ile Glu Glu Lys Arg 
            180                 185                 190         


Arg Asn Gln Arg Glu Arg Gly Glu Lys Glu Leu Val Ala Pro Phe Lys 
        195                 200                 205             


Tyr Ser Asp Lys Arg Asp Asp Leu Ile Ala Ala Ile Tyr Asn Asp Ala 
    210                 215                 220                 


Phe Asp Val Tyr Ile Asp Lys Lys Lys Asp Ser Leu Lys Glu Ser Ser 
225                 230                 235                 240 


Lys Ala Lys Tyr Asn Thr Lys Ser Asp Pro Gln Gln Glu Glu Gly Asp 
                245                 250                 255     


Leu Lys Ile Pro Ile Ser Lys Asn Gly Val Val Phe Leu Leu Ser Leu 
            260                 265                 270         


Phe Leu Thr Lys Gln Glu Ile His Ala Phe Lys Ser Lys Ile Ala Gly 
        275                 280                 285             


Phe Lys Ala Thr Val Ile Asp Glu Ala Thr Val Ser Glu Ala Thr Val 
    290                 295                 300                 


Ser His Gly Lys Asn Ser Ile Cys Phe Met Ala Thr His Glu Ile Phe 
305                 310                 315                 320 


Ser His Leu Ala Tyr Lys Lys Leu Lys Arg Lys Val Arg Thr Ala Glu 
                325                 330                 335     


Ile Asn Tyr Gly Glu Ala Glu Asn Ala Glu Gln Leu Ser Val Tyr Ala 
            340                 345                 350         


Lys Glu Thr Leu Met Met Gln Met Leu Asp Glu Leu Ser Lys Val Pro 
        355                 360                 365             


Asp Val Val Tyr Gln Asn Leu Ser Glu Asp Val Gln Lys Thr Phe Ile 
    370                 375                 380                 


Glu Asp Trp Asn Glu Tyr Leu Lys Glu Asn Asn Gly Asp Val Gly Thr 
385                 390                 395                 400 


Met Glu Glu Glu Gln Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu 
                405                 410                 415     


Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Gln 
            420                 425                 430         


Phe Pro Thr Leu Arg Phe Gln Val His Leu Gly Asn Tyr Leu His Asp 
        435                 440                 445             


Ser Arg Pro Lys Glu Asn Leu Ile Ser Asp Arg Arg Ile Lys Glu Lys 
    450                 455                 460                 


Ile Thr Val Phe Gly Arg Leu Ser Glu Leu Glu His Lys Lys Ala Leu 
465                 470                 475                 480 


Phe Ile Lys Asn Thr Glu Thr Asn Glu Asp Arg Glu His Tyr Trp Glu 
                485                 490                 495     


Ile Phe Pro Asn Pro Asn Tyr Asp Phe Pro Lys Glu Asn Ile Ser Val 
            500                 505                 510         


Asn Asp Lys Asp Phe Pro Ile Ala Gly Ser Ile Leu Asp Arg Glu Lys 
        515                 520                 525             


Gln Pro Val Ala Gly Lys Ile Gly Ile Lys Val Lys Leu Leu Asn Gln 
    530                 535                 540                 


Gln Tyr Val Ser Glu Val Asp Lys Ala Val Lys Ala His Gln Leu Lys 
545                 550                 555                 560 


Gln Arg Lys Ala Ser Lys Pro Ser Ile Gln Asn Ile Ile Glu Glu Ile 
                565                 570                 575     


Val Pro Ile Asn Glu Ser Asn Pro Lys Glu Ala Ile Val Phe Gly Gly 
            580                 585                 590         


Gln Pro Thr Ala Tyr Leu Ser Met Asn Asp Ile His Ser Ile Leu Tyr 
        595                 600                 605             


Glu Phe Phe Asp Lys Trp Glu Lys Lys Lys Glu Lys Leu Glu Lys Lys 
    610                 615                 620                 


Gly Glu Lys Glu Leu Arg Lys Glu Ile Gly Lys Glu Leu Glu Lys Lys 
625                 630                 635                 640 


Ile Val Gly Lys Ile Gln Ala Gln Ile Gln Gln Ile Ile Asp Lys Asp 
                645                 650                 655     


Thr Asn Ala Lys Ile Leu Lys Pro Tyr Gln Asp Gly Asn Ser Thr Ala 
            660                 665                 670         


Ile Asp Lys Glu Lys Leu Ile Lys Asp Leu Lys Gln Glu Gln Asn Ile 
        675                 680                 685             


Leu Gln Lys Leu Lys Asp Glu Gln Thr Val Arg Glu Lys Glu Tyr Asn 
    690                 695                 700                 


Asp Phe Ile Ala Tyr Gln Asp Lys Asn Arg Glu Ile Asn Lys Val Arg 
705                 710                 715                 720 


Asp Arg Asn His Lys Gln Tyr Leu Lys Asp Asn Leu Lys Arg Lys Tyr 
                725                 730                 735     


Pro Glu Ala Pro Ala Arg Lys Glu Val Leu Tyr Tyr Arg Glu Lys Gly 
            740                 745                 750         


Lys Val Ala Val Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Thr 
        755                 760                 765             


Asp Phe Lys Asn Glu Trp Lys Gly Glu Gln His Ser Leu Leu Gln Lys 
    770                 775                 780                 


Ser Leu Ala Tyr Tyr Glu Gln Cys Lys Glu Glu Leu Lys Asn Leu Leu 
785                 790                 795                 800 


Pro Glu Lys Val Phe Gln His Leu Pro Phe Lys Leu Gly Gly Tyr Phe 
                805                 810                 815     


Gln Gln Lys Tyr Leu Tyr Gln Phe Tyr Thr Cys Tyr Leu Asp Lys Arg 
            820                 825                 830         


Leu Glu Tyr Ile Ser Gly Leu Val Gln Gln Ala Glu Asn Phe Lys Ser 
        835                 840                 845             


Glu Asn Lys Val Phe Lys Lys Val Glu Asn Glu Cys Phe Lys Phe Leu 
    850                 855                 860                 


Lys Lys Gln Asn Tyr Thr His Lys Glu Leu Asp Ala Arg Val Gln Ser 
865                 870                 875                 880 


Ile Leu Gly Tyr Pro Ile Phe Leu Glu Arg Gly Phe Met Asp Glu Lys 
                885                 890                 895     


Pro Thr Ile Ile Lys Gly Lys Thr Phe Lys Gly Asn Glu Ala Leu Phe 
            900                 905                 910         


Ala Asp Trp Phe Arg Tyr Tyr Lys Glu Tyr Gln Asn Phe Gln Thr Phe 
        915                 920                 925             


Tyr Asp Thr Glu Asn Tyr Pro Leu Val Glu Leu Glu Lys Lys Gln Ala 
    930                 935                 940                 


Asp Arg Lys Arg Lys Thr Lys Ile Tyr Gln Gln Lys Lys Asn Asp Val 
945                 950                 955                 960 


Phe Thr Leu Leu Met Ala Lys His Ile Phe Lys Ser Val Phe Lys Gln 
                965                 970                 975     


Asp Ser Ile Asp Gln Phe Ser Leu Glu Asp Leu Tyr Gln Ser Arg Glu 
            980                 985                 990         


Glu Arg Leu Gly Asn Gln Glu Arg  Ala Arg Gln Thr Gly  Glu Arg Asn 
        995                 1000                 1005             


Thr Asn  Tyr Ile Trp Asn Lys  Thr Val Asp Leu Lys  Leu Cys Asp 
    1010                 1015                 1020             


Gly Lys  Ile Thr Val Glu Asn  Val Lys Leu Lys Asn  Val Gly Asp 
    1025                 1030                 1035             


Phe Ile  Lys Tyr Glu Tyr Asp  Gln Arg Val Gln Ala  Phe Leu Lys 
    1040                 1045                 1050             


Tyr Glu  Glu Asn Ile Glu Trp  Gln Ala Phe Leu Ile  Lys Glu Ser 
    1055                 1060                 1065             


Lys Glu  Glu Glu Asn Tyr Pro  Tyr Val Val Glu Arg  Glu Ile Glu 
    1070                 1075                 1080             


Gln Tyr  Glu Lys Val Arg Arg  Glu Glu Leu Leu Lys  Glu Val His 
    1085                 1090                 1095             


Leu Ile  Glu Glu Tyr Ile Leu  Glu Lys Val Lys Asp  Lys Glu Ile 
    1100                 1105                 1110             


Leu Lys  Lys Gly Asp Asn Gln  Asn Phe Lys Tyr Tyr  Ile Leu Asn 
    1115                 1120                 1125             


Gly Leu  Leu Lys Gln Leu Lys  Asn Glu Asp Val Glu  Ser Tyr Lys 
    1130                 1135                 1140             


Val Phe  Asn Leu Asn Thr Glu  Pro Glu Asp Val Asn  Ile Asn Gln 
    1145                 1150                 1155             


Leu Lys  Gln Glu Ala Thr Asp  Leu Glu Gln Lys Ala  Phe Val Leu 
    1160                 1165                 1170             


Thr Tyr  Ile Arg Asn Lys Phe  Ala His Asn Gln Leu  Pro Lys Lys 
    1175                 1180                 1185             


Glu Phe  Trp Asp Tyr Cys Gln  Glu Lys Tyr Gly Lys  Ile Glu Lys 
    1190                 1195                 1200             


Glu Lys  Thr Tyr Ala Glu Tyr  Phe Ala Glu Val Phe  Lys Lys Glu 
    1205                 1210                 1215             


Lys Glu  Ala Leu Ile Lys 
    1220                 


<210>  107
<211>  219
<212>  PRT
<213>  Bergeyella zoohelcum


<220>
<221>  PEPTIDE
<222>  (1)..(219)
<223>  hypothetical protein:  /protein_id=EKB54194.1

<400>  107

Met Asp Arg Leu Ser Ile Tyr Glu Leu Leu Ser Phe Val Val Pro Gly 
1               5                   10                  15      


Val Ile Met Ile Glu Leu Ile Asn Phe Ser Ala Glu Tyr Val Phe Gly 
            20                  25                  30          


Lys Ala Pro Leu Ile Thr Ala Gly Asn Leu Ser Asp Gly Leu Leu Phe 
        35                  40                  45              


Phe Ala Ile Ala Leu Phe Ile Gly Cys Leu Ile His Ile Ile Thr Phe 
    50                  55                  60                  


Trp Leu Ile Lys Arg Lys Trp Tyr Lys Lys Leu Ala Cys Thr Pro Met 
65                  70                  75                  80  


Asp Lys Met Lys Asn Asp Glu Tyr Ile Thr Glu Ile Leu Pro Asp Leu 
                85                  90                  95      


Lys Glu Ile Tyr Arg Thr Asn Lys Gly Ile Ser Val Thr Glu Asn Ile 
            100                 105                 110         


Ser Asn Gly Ser Val Phe Asp Thr Ala Tyr Tyr Tyr Leu Glu Ala Gln 
        115                 120                 125             


Gly Lys Ile Ser Gln Ala Lys Asn Phe Gln Ser Ile Tyr Phe Leu Phe 
    130                 135                 140                 


Arg Asn Ile Val Thr Leu Ser Leu Phe Val Leu Pro Val Ser Val Ile 
145                 150                 155                 160 


Phe Leu Leu Ala Ser Phe Phe Met Asn Asp Cys Ser Leu Ser Glu Lys 
                165                 170                 175     


Ile Ile Thr Ile Ile Ile Gly Thr Phe Val Leu Gly Gly Leu Ser Ser 
            180                 185                 190         


Val Ile Ala Gln Trp Phe Arg Val Lys Met Thr Asp Arg Ile Phe Gly 
        195                 200                 205             


Leu Tyr Tyr Ala Glu Leu Thr His Asn Lys Lys 
    210                 215                 


<210>  108
<211>  1121
<212>  PRT
<213>  Fusobacterium perfoetens


<220>
<221>  PEPTIDE
<222>  (1)..(1121)
<223>  hypothetical protein: /protein_id=WP_027128616.1

<400>  108

Met Gly Lys Pro Asn Arg Ser Ser Ile Ile Lys Ile Ile Ile Ser Asn 
1               5                   10                  15      


Tyr Asp Asn Lys Gly Ile Lys Glu Val Lys Val Arg Tyr Asn Lys Gln 
            20                  25                  30          


Ala Gln Leu Asp Thr Phe Leu Ile Lys Ser Glu Leu Lys Asp Gly Lys 
        35                  40                  45              


Phe Ile Leu Tyr Ser Ile Val Asp Lys Ala Arg Glu Lys Tyr Arg Tyr 
    50                  55                  60                  


Ser Phe Glu Ile Asp Lys Thr Asn Ile Asn Lys Asn Glu Ile Leu Ile 
65                  70                  75                  80  


Ile Lys Lys Asp Ile Tyr Ser Asn Lys Glu Asp Lys Val Ile Arg Lys 
                85                  90                  95      


Tyr Ile Leu Ser Phe Glu Val Ser Glu Lys Asn Asp Arg Thr Ile Val 
            100                 105                 110         


Thr Lys Ile Lys Asp Cys Leu Glu Thr Gln Lys Lys Glu Lys Phe Glu 
        115                 120                 125             


Arg Glu Asn Thr Arg Arg Leu Ile Ser Glu Thr Glu Arg Lys Leu Leu 
    130                 135                 140                 


Ser Glu Glu Thr Gln Lys Thr Tyr Ser Lys Ile Ala Cys Cys Ser Pro 
145                 150                 155                 160 


Glu Asp Ile Asp Ser Val Lys Ile Tyr Lys Ile Lys Arg Tyr Leu Ala 
                165                 170                 175     


Tyr Arg Ser Asn Met Leu Leu Phe Phe Ser Leu Ile Asn Asp Ile Phe 
            180                 185                 190         


Val Lys Gly Val Val Lys Asp Asn Gly Glu Glu Val Gly Glu Ile Trp 
        195                 200                 205             


Arg Ile Ile Asp Ser Lys Glu Ile Asp Glu Lys Lys Thr Tyr Asp Leu 
    210                 215                 220                 


Leu Val Glu Asn Phe Lys Lys Arg Met Ser Gln Glu Phe Ile Asn Tyr 
225                 230                 235                 240 


Lys Gln Ser Ile Glu Asn Lys Ile Glu Lys Asn Thr Asn Lys Ile Lys 
                245                 250                 255     


Glu Ile Glu Gln Lys Leu Lys Lys Glu Lys Tyr Lys Lys Glu Ile Asn 
            260                 265                 270         


Arg Leu Lys Lys Gln Leu Ile Glu Leu Asn Arg Glu Asn Asp Leu Leu 
        275                 280                 285             


Glu Lys Asp Lys Ile Glu Leu Ser Asp Glu Glu Ile Arg Glu Asp Ile 
    290                 295                 300                 


Glu Lys Ile Leu Lys Ile Tyr Ser Asp Leu Arg His Lys Leu Met His 
305                 310                 315                 320 


Tyr Asn Tyr Gln Tyr Phe Glu Asn Leu Phe Glu Asn Lys Lys Ile Ser 
                325                 330                 335     


Lys Glu Lys Asn Glu Asp Val Asn Leu Thr Glu Leu Leu Asp Leu Asn 
            340                 345                 350         


Leu Phe Arg Tyr Leu Pro Leu Val Arg Gln Leu Lys Leu Glu Asn Lys 
        355                 360                 365             


Thr Asn Tyr Leu Glu Lys Glu Asp Lys Ile Thr Val Leu Gly Val Ser 
    370                 375                 380                 


Asp Ser Ala Ile Lys Tyr Tyr Ser Tyr Tyr Asn Phe Leu Cys Glu Gln 
385                 390                 395                 400 


Lys Asn Gly Phe Asn Asn Phe Ile Asn Ser Phe Phe Ser Asn Asp Gly 
                405                 410                 415     


Glu Glu Asn Lys Ser Phe Lys Glu Lys Ile Asn Leu Ser Leu Glu Lys 
            420                 425                 430         


Glu Ile Glu Ile Met Glu Lys Glu Thr Asn Glu Lys Ile Lys Glu Ile 
        435                 440                 445             


Asn Lys Asn Glu Leu Gln Leu Met Lys Glu Gln Lys Glu Leu Gly Thr 
    450                 455                 460                 


Ala Tyr Val Leu Asp Ile His Ser Leu Asn Asp Tyr Lys Ile Ser His 
465                 470                 475                 480 


Asn Glu Arg Asn Lys Asn Val Lys Leu Gln Asn Asp Ile Met Asn Gly 
                485                 490                 495     


Asn Arg Asp Lys Asn Ala Leu Asp Lys Ile Asn Lys Lys Leu Val Glu 
            500                 505                 510         


Leu Lys Ile Lys Met Asp Lys Ile Thr Lys Arg Asn Ser Ile Leu Arg 
        515                 520                 525             


Leu Lys Tyr Lys Leu Gln Val Ala Tyr Gly Phe Leu Met Glu Glu Tyr 
    530                 535                 540                 


Lys Gly Asn Ile Lys Lys Phe Lys Asp Glu Phe Asp Ile Ser Lys Glu 
545                 550                 555                 560 


Lys Ile Lys Ser Tyr Lys Ser Lys Gly Glu Lys Tyr Leu Glu Val Lys 
                565                 570                 575     


Ser Glu Lys Lys Tyr Ile Thr Lys Ile Leu Asn Ser Ile Glu Asp Ile 
            580                 585                 590         


His Asn Ile Thr Trp Leu Lys Asn Gln Glu Glu Asn Asn Leu Phe Lys 
        595                 600                 605             


Phe Tyr Val Leu Thr Tyr Ile Leu Leu Pro Phe Glu Phe Arg Gly Asp 
    610                 615                 620                 


Phe Leu Gly Phe Val Lys Lys His Tyr Tyr Asp Ile Lys Asn Val Glu 
625                 630                 635                 640 


Phe Leu Asp Glu Asn Asn Asp Arg Leu Thr Pro Glu Gln Leu Glu Lys 
                645                 650                 655     


Met Lys Asn Asp Ser Phe Phe Asn Lys Ile Arg Leu Phe Glu Lys Asn 
            660                 665                 670         


Ser Lys Lys Tyr Asp Ile Leu Lys Glu Ser Ile Leu Thr Ser Glu Arg 
        675                 680                 685             


Ile Gly Lys Tyr Phe Ser Leu Leu Asn Thr Gly Ala Lys Tyr Phe Glu 
    690                 695                 700                 


Tyr Gly Gly Glu Glu Asn Arg Gly Ile Phe Asn Lys Asn Ile Ile Ile 
705                 710                 715                 720 


Pro Ile Phe Lys Tyr Tyr Gln Ile Val Leu Lys Leu Tyr Asn Asp Val 
                725                 730                 735     


Glu Leu Ala Met Leu Leu Thr Leu Ser Glu Ser Asp Glu Lys Asp Ile 
            740                 745                 750         


Asn Lys Ile Lys Glu Leu Val Thr Leu Lys Glu Lys Val Ser Pro Lys 
        755                 760                 765             


Lys Ile Asp Tyr Glu Lys Lys Tyr Lys Phe Ser Val Leu Leu Asp Cys 
    770                 775                 780                 


Phe Asn Arg Ile Ile Asn Leu Gly Lys Lys Asp Phe Leu Ala Ser Glu 
785                 790                 795                 800 


Glu Val Lys Glu Val Ala Lys Thr Phe Thr Asn Leu Ala Tyr Leu Arg 
                805                 810                 815     


Asn Lys Ile Cys His Leu Asn Tyr Ser Lys Phe Ile Asp Asp Leu Leu 
            820                 825                 830         


Thr Ile Asp Thr Asn Lys Ser Thr Thr Asp Ser Glu Gly Lys Leu Leu 
        835                 840                 845             


Ile Asn Asp Arg Ile Arg Lys Leu Ile Lys Phe Ile Arg Glu Asn Asn 
    850                 855                 860                 


Gln Lys Met Asn Ile Ser Ile Asp Tyr Asn Tyr Ile Asn Asp Tyr Tyr 
865                 870                 875                 880 


Met Lys Lys Glu Lys Phe Ile Phe Gly Gln Arg Lys Gln Ala Lys Thr 
                885                 890                 895     


Ile Ile Asp Ser Gly Lys Lys Ala Asn Lys Arg Asn Lys Ala Glu Glu 
            900                 905                 910         


Leu Leu Lys Met Tyr Arg Val Lys Lys Glu Asn Ile Asn Leu Ile Tyr 
        915                 920                 925             


Glu Leu Ser Lys Lys Leu Asn Glu Leu Thr Lys Ser Glu Leu Phe Leu 
    930                 935                 940                 


Leu Asp Lys Lys Leu Leu Lys Asp Ile Asp Phe Thr Asp Val Lys Ile 
945                 950                 955                 960 


Lys Asn Lys Ser Phe Phe Glu Leu Lys Asn Asp Val Lys Glu Val Ala 
                965                 970                 975     


Asn Ile Lys Gln Ala Leu Gln Lys His Ser Ser Glu Leu Ile Gly Ile 
            980                 985                 990         


Tyr Lys Lys Glu Val Ile Met Ala  Ile Lys Arg Ser Ile  Val Ser Lys 
        995                 1000                 1005             


Leu Ile  Tyr Asp Glu Glu Lys  Val Leu Ser Ile Ile  Ile Tyr Asp 
    1010                 1015                 1020             


Lys Thr  Asn Lys Lys Tyr Glu  Asp Phe Leu Leu Glu  Ile Arg Arg 
    1025                 1030                 1035             


Glu Arg  Asp Ile Asn Lys Phe  Gln Phe Leu Ile Asp  Glu Lys Lys 
    1040                 1045                 1050             


Glu Lys  Leu Gly Tyr Glu Lys  Ile Ile Glu Thr Lys  Glu Lys Lys 
    1055                 1060                 1065             


Lys Val  Val Val Lys Ile Gln  Asn Asn Ser Glu Leu  Val Ser Glu 
    1070                 1075                 1080             


Pro Arg  Ile Ile Lys Asn Lys  Asp Lys Lys Lys Ala  Lys Thr Pro 
    1085                 1090                 1095             


Glu Glu  Ile Ser Lys Leu Gly  Ile Leu Asp Leu Thr  Asn His Tyr 
    1100                 1105                 1110             


Cys Phe  Asn Leu Lys Ile Thr  Leu 
    1115                 1120     


<210>  109
<211>  30
<212>  DNA
<213>  Archaeoglobus fulgidus


<220>
<221>  Unsure
<222>  (1)..(30)
<223>  DNA coding for Type IA cognate crRNA repeat sequence

<400>  109
gttgaaatca gaccaaaatg ggattgaaag                                        30


<210>  110
<211>  29
<212>  DNA
<213>  Clostridium difficile


<220>
<221>  Unsure
<222>  (1)..(29)
<223>  DNA coding for Type IB cognate crRNA repeat sequence

<400>  110
gttttatatt aactaagtgg tatgtaaat                                         29


<210>  111
<211>  32
<212>  DNA
<213>  Bacillus halodurans


<220>
<221>  Unsure
<222>  (1)..(32)
<223>  DNA coding for Type IC cognate crRNA repeat sequence

<400>  111
gtcgcactct acacgagtgc gtggattgaa at                                     32


<210>  112
<211>  37
<212>  DNA
<213>  Cyanothece sp


<220>
<221>  Unsure
<222>  (1)..(37)
<223>  DNA coding for Type ID cognate crRNA repeat sequence

<400>  112
gtttcaatcc cattactagg attcattaaa aagaaac                                37


<210>  113
<211>  29
<212>  DNA
<213>  Escherichia coli


<220>
<221>  Unsure
<222>  (1)..(29)
<223>  DNA coding for Type IE cognate crRNA repeat sequence

<400>  113
cggtttatcc ccgctggcgc ggggaactc                                         29


<210>  114
<211>  29
<212>  DNA
<213>  Yersinia pseudotuberculosis


<220>
<221>  Unsure
<222>  (1)..(29)
<223>  DNA coding for Type IF cognate crRNA repeat sequence

<400>  114
cggtttatcc ccgctggcgc ggggaactc                                         29


<210>  115
<211>  28
<212>  DNA
<213>  Shewanella putrefaciens


<220>
<221>  Unsure
<222>  (1)..(28)
<223>  DNA coding for Type IF cognate crRNA repeat sequence

<400>  115
gttcaccgcc gcacaggcgg cttagaaa                                          28


<210>  116
<211>  32
<212>  DNA
<213>  Streptococcus pyogenes


<220>
<221>  Unsure
<222>  (1)..(32)
<223>  DNA coding for Type IIA cognate crRNA repeat sequence

<400>  116
atttcaatcc actcacccat gaagggtgag ac                                     32


<210>  117
<211>  37
<212>  DNA
<213>  Legionella pneumophila


<220>
<221>  Unsure
<222>  (1)..(37)
<223>  DNA coding for Type IIB cognate crRNA repeat sequence

<400>  117
ccaataatcc ctcatctaaa aatccaacca ctgaaac                                37


<210>  118
<211>  26
<212>  DNA
<213>  Neisseria meningitidis


<220>
<221>  Unsure
<222>  (1)..(26)
<223>  DNA coding for Type IIC cognate crRNA repeat sequence

<400>  118
gattcccgcg ttcgcgggaa tgacgg                                            26


<210>  119
<211>  36
<212>  DNA
<213>  Staphylococcus epidermidis


<220>
<221>  Unsure
<222>  (1)..(36)
<223>  DNA coding for Type IIIA cognate crRNA repeat sequence

<400>  119
gatcgatacc caccccgaag aaaaggggac gagaac                                 36


<210>  120
<211>  30
<212>  DNA
<213>  Pyrococcus furiosus


<220>
<221>  Unsure
<222>  (1)..(30)
<223>  DNA coding for Type IIIB cognate crRNA repeat sequence

<400>  120
gttccaataa gactaaaata gaattgaaag                                        30


<210>  121
<211>  35
<212>  DNA
<213>  Marinomonas mediterranea


<220>
<221>  Unsure
<222>  (1)..(35)
<223>  DNA coding for Type IIIB* cognate crRNA repeat sequence

<400>  121
gtctcaacgg cctaagcggc cagcgggtct gaaac                                  35


<210>  122
<211>  30
<212>  DNA
<213>  Methanothermobacter thermautotrophicus


<220>
<221>  Unsure
<222>  (1)..(30)
<223>  DNA coding for Type IIIC cognate crRNA repeat sequence

<400>  122
atttcaatcc cattttggtc tgattttaac                                        30


<210>  123
<211>  37
<212>  DNA
<213>  Synechocystis spp


<220>
<221>  Unsure
<222>  (1)..(37)
<223>  DNA coding for Type IIID cognate crRNA repeat sequence

<400>  123
ctttccttct actaatcccg gcgatcggga ctgaaac                                37


<210>  124
<211>  36
<212>  DNA
<213>  Thioalkalivibrio sp.


<220>
<221>  Unsure
<222>  (1)..(36)
<223>  DNA coding for Type IV cognate crRNA repeat sequence

<400>  124
gtggaaagca cgtccctgtg ggggcgtggt tggaac                                 36


<210>  125
<211>  36
<212>  DNA
<213>  Francisella cf. novicida Fx1


<220>
<221>  Unsure
<222>  (1)..(36)
<223>  DNA coding for TypeV A cognate crRNA repeat sequence

<400>  125
atctacaaca gtagaaatta tttaaagttc ttagac                                 36


<210>  126
<211>  36
<212>  DNA
<213>  Alicyclobacillus acidoterrestris


<220>
<221>  Unsure
<222>  (1)..(36)
<223>  DNA coding for TypeV B cognate crRNA repeat sequence

<400>  126
gtcggatcac tgagcgagcg atctgagaag tggcac                                 36


<210>  127
<211>  26
<212>  DNA
<213>  Oleiphilus sp


<220>
<221>  Unsure
<222>  (1)..(26)
<223>  DNA coding for TypeV C cognate crRNA repeat sequence

<400>  127
agaattactg atgttgtgat gaaggc                                            26


<210>  128
<211>  26
<212>  DNA
<213>  Bacterium CG09_39_24


<220>
<221>  Unsure
<222>  (1)..(26)
<223>  DNA coding for TypeV D cognate crRNA repeat sequence

<400>  128
actccgaaag tatcggggat aaaggc                                            26


<210>  129
<211>  37
<212>  DNA
<213>  Deltaproteobacteria bacterium


<220>
<221>  Unsure
<222>  (1)..(37)
<223>  DNA coding for TypeV E cognate crRNA repeat sequence

<400>  129
atttgaaggt atctccgata agtaaaacgc atcaaag                                37


<210>  130
<211>  36
<212>  DNA
<213>  Leptotrichia shahii DSM 19757


<220>
<221>  Unsure
<222>  (1)..(36)
<223>  DNA coding for TypeVI A cognate crRNA repeat sequence

<400>  130
gttttagtcc ccttcgatat tggggtggtc tatatc                                 36


<210>  131
<211>  36
<212>  DNA
<213>  Prevotella buccae


<220>
<221>  Unsure
<222>  (1)..(36)
<223>  DNA coding for TypeVI B1 cognate crRNA repeat sequence

<400>  131
gttgcatctg ccttcttttt gaaaggtaaa aacaac                                 36


<210>  132
<211>  29
<212>  DNA
<213>  Bergeyella zoohelcum


<220>
<221>  Unsure
<222>  (1)..(29)
<223>  DNA coding for TypeVI B2 cognate crRNA repeat sequence

<400>  132
attctaatcg caccataagg aattgaaac                                         29


<210>  133
<211>  30
<212>  DNA
<213>  Fusobacterium perfoetens


<220>
<221>  Unsure
<222>  (1)..(30)
<223>  DNA coding for TypeVI C cognate crRNA repeat sequence

<400>  133
gactaaaacc aagaaaattg gtatttaaac                                        30


<210>  134
<211>  91
<212>  DNA
<213>  Streptococcus pyogenes


<220>
<221>  gene
<222>  (1)..(91)
<223>  DNA coding for TypeIIA cognate tracRNA

<400>  134
ttgttggaac cattcaaaac agcatagcaa gttaaaataa ggctagtccg ttatcaactt       60

gaaaaagtgg caccgagtcg gtgctttttt t                                      91


<210>  135
<211>  101
<212>  DNA
<213>  Legionella pneumophila


<220>
<221>  gene
<222>  (1)..(101)
<223>  DNA coding for TypeIIB cognate tracRNA

<400>  135
ttaattttgt tgatttcagg gtatcgaaat ttagatgatt tctaatttaa ttattgcctt       60

ctttttcgaa aaatcaagcc taaataatgc aatttgctat t                          101


<210>  136
<211>  109
<212>  DNA
<213>  Neisseria meningitidis


<220>
<221>  gene
<222>  (1)..(109)
<223>  DNA coding for Type II-C cognate tracRNA

<400>  136
acatattgtc gcactgcgaa atgagaaccg ttgctacaat aaggccgtct gaaaagatgt       60

gccgcaacgc tctgcccctt aaagcttctg ctttaagggg catcgttta                  109


<210>  137
<211>  103
<212>  DNA
<213>  Alicyclobacillus acidoterrestris


<220>
<221>  gene
<222>  (1)..(103)
<223>  DNA coding for TypeV-B cognate tracRNA

<400>  137
agaacgctcg ctcagtgttc tgacctttcg agcgcctgtt cagggcgaaa accctgggag       60

gcgctcgaat cataggtggg acaagggatt cgcggcgaaa acg                        103


<210>  138
<211>  91
<212>  DNA
<213>  Deltaproteobacteria bacterium


<220>
<221>  gene
<222>  (1)..(91)
<223>  DNA coding for TypeV-E cognate tracRNA

<400>  138
cttatttatc ggagatagct ccgggtgcaa actcggagct gtttttttac gaaacagcta       60

attttagcca aaagttcttt gaaaacctga t                                      91


<210>  139
<211>  99
<212>  DNA
<213>  Synthetic


<220>
<221>  promoter
<222>  (1)..(99)
<223>  PLtetO-1 (lacking repressor) + RBS

<400>  139
tccctatcag tgatagagat tgacatccct atcagtgata gagatactga gcacatcagc       60

aggacgcact gaccgaattc attaaagagg agaaaggta                              99


<210>  140
<211>  717
<212>  DNA
<213>  Synthetic


<220>
<221>  CDS
<222>  (1)..(717)
<223>  gfp gene encoding Green Fluorescent Protein

<400>  140
atg cgt aaa ggc gaa gag ctg ttc act ggt gtc gtc cct att ctg gtg         48
Met Arg Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val           
1               5                   10                  15                

gaa ctg gat ggt gat gtc aac ggt cat aag ttt tcc gtg cgt ggc gag         96
Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu           
            20                  25                  30                    

ggt gaa ggt gac gca act aat ggt aaa ctg acg ctg aag ttc atc tgt        144
Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys           
        35                  40                  45                        

act act ggt aaa ctg ccg gta cct tgg ccg act ctg gta acg acg ctg        192
Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu           
    50                  55                  60                            

act tat ggt gtt cag tgc ttt gct cgt tat ccg gac cat atg aag cag        240
Thr Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln           
65                  70                  75                  80            

cat gac ttc ttc aag tcc gcc atg ccg gaa ggc tat gtg cag gaa cgc        288
His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg           
                85                  90                  95                

acg att tcc ttt aag gat gac ggc acg tac aaa acg cgt gcg gaa gtg        336
Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val           
            100                 105                 110                   

aaa ttt gaa ggc gat acc ctg gta aac cgc att gag ctg aaa ggc att        384
Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile           
        115                 120                 125                       

gac ttt aaa gaa gac ggc aat atc ctg ggc cat aag ctg gaa tac aat        432
Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn           
    130                 135                 140                           

ttt aac agc cac aat gtt tac atc acc gcc gat aaa caa aaa aat ggc        480
Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly           
145                 150                 155                 160           

att aaa gcg aat ttt aaa att cgc cac aac gtg gag gat ggc agc gtg        528
Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val           
                165                 170                 175               

cag ctg gct gat cac tac cag caa aac act cca atc ggt gat ggt cct        576
Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro           
            180                 185                 190                   

gtt ctg ctg cca gac aat cac tat ctg agc acg caa agc gtt ctg tct        624
Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser           
        195                 200                 205                       

aaa gat ccg aac gag aaa cgc gat cat atg gtt ctg ctg gag ttc gta        672
Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val           
    210                 215                 220                           

acc gca gcg ggc atc acg cat ggt atg gat gaa ctg tac aaa tga            717
Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys                   
225                 230                 235                               


<210>  141
<211>  238
<212>  PRT
<213>  Synthetic

<400>  141

Met Arg Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210>  142
<211>  142
<212>  DNA
<213>  Synthetic


<220>
<221>  terminator
<222>  (1)..(142)
<223>  rrnB T1 terminator

<400>  142
ctgcagcccg ggggatccca tggtacgcgt gctagaggca tcaaataaaa cgaaaggctc       60

agtcgaaaga ctgggccttt cgttttatct gttgtttgtc ggtgaacgct ctcctgagta      120

ggacaaatcc gccgccctag ac                                               142


<210>  143
<211>  919
<212>  DNA
<213>  Synthetic


<220>
<221>  rep_origin
<222>  (1)..(919)
<223>  ColE1origin of replication + terminator rrnaB

<400>  143
ctaggcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc       60

acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg      120

aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat      180

cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag      240

gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga      300

tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcaatgctc acgctgtagg      360

tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt      420

cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac      480

gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc      540

ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt      600

ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc      660

ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc      720

agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg      780

aacgaaaact cacgttaagg gattttggtc atgactagtg cttggattct caccaataaa      840

aaacgcccgg cggcaaccga gcgttctgaa caaatccaga tggagttctg aggtcattac      900

tggatctatc aacaggagt                                                   919


<210>  144
<211>  795
<212>  DNA
<213>  Synthetic


<220>
<221>  CDS
<222>  (1)..(795)
<223>  Kanamycin resistance gene

<400>  144
atg att gaa caa gat gga ttg cac gca ggt tct ccg gcc gct tgg gtg         48
Met Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala Trp Val           
1               5                   10                  15                

gag agg cta ttc ggc tat gac tgg gca caa cag aca atc ggc tgc tct         96
Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly Cys Ser           
            20                  25                  30                    

gat gcc gcc gtg ttc cgg ctg tca gcg cag ggg cgc ccg gtt ctt ttt        144
Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val Leu Phe           
        35                  40                  45                        

gtc aag acc gac ctg tcc ggt gcc ctg aat gaa ctg cag gac gag gca        192
Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp Glu Ala           
    50                  55                  60                            

gcg cgg cta tcg tgg ctg gcc acg acg ggc gtt cct tgc gca gct gtg        240
Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala Ala Val           
65                  70                  75                  80            

ctc gac gtt gtc act gaa gcg gga agg gac tgg ctg cta ttg ggc gaa        288
Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu Gly Glu           
                85                  90                  95                

gtg ccg ggg cag gat ctc ctg tca tct cac ctt gct cct gcc gag aaa        336
Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala Glu Lys           
            100                 105                 110                   

gta tcc atc atg gct gat gca atg cgg cgg ctg cat acg ctt gat ccg        384
Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu Asp Pro           
        115                 120                 125                       

gct acc tgc cca ttc gac cac caa gcg aaa cat cgc atc gag cga gca        432
Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu Arg Ala           
    130                 135                 140                           

cgt act cgg atg gaa gcc ggt ctt gtc gat cag gat gat ctg gac gaa        480
Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu Asp Glu           
145                 150                 155                 160           

gag cat cag ggg ctc gcg cca gcc gaa ctg ttc gcc agg ctc aag gcg        528
Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu Lys Ala           
                165                 170                 175               

cgc atg ccc gac ggc gag gat ctc gtc gtg acc cat ggc gat gcc tgc        576
Arg Met Pro Asp Gly Glu Asp Leu Val Val Thr His Gly Asp Ala Cys           
            180                 185                 190                   

ttg ccg aat atc atg gtg gaa aat ggc cgc ttt tct gga ttc atc gac        624
Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe Ile Asp           
        195                 200                 205                       

tgt ggc cgg ctg ggt gtg gcg gac cgc tat cag gac ata gcg ttg gct        672
Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala Leu Ala           
    210                 215                 220                           

acc cgt gat att gct gaa gag ctt ggc ggc gaa tgg gct gac cgc ttc        720
Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp Arg Phe           
225                 230                 235                 240           

ctc gtg ctt tac ggt atc gcc gct ccc gat tcg cag cgc atc gcc ttc        768
Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile Ala Phe           
                245                 250                 255               

tat cgc ctt ctt gac gag ttc ttc tga                                    795
Tyr Arg Leu Leu Asp Glu Phe Phe                                           
            260                                                           


<210>  145
<211>  264
<212>  PRT
<213>  Synthetic

<400>  145

Met Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala Trp Val 
1               5                   10                  15      


Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly Cys Ser 
            20                  25                  30          


Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val Leu Phe 
        35                  40                  45              


Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp Glu Ala 
    50                  55                  60                  


Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala Ala Val 
65                  70                  75                  80  


Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu Gly Glu 
                85                  90                  95      


Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala Glu Lys 
            100                 105                 110         


Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu Asp Pro 
        115                 120                 125             


Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu Arg Ala 
    130                 135                 140                 


Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu Asp Glu 
145                 150                 155                 160 


Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu Lys Ala 
                165                 170                 175     


Arg Met Pro Asp Gly Glu Asp Leu Val Val Thr His Gly Asp Ala Cys 
            180                 185                 190         


Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe Ile Asp 
        195                 200                 205             


Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala Leu Ala 
    210                 215                 220                 


Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp Arg Phe 
225                 230                 235                 240 


Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile Ala Phe 
                245                 250                 255     


Tyr Arg Leu Leu Asp Glu Phe Phe 
            260                 


<210>  146
<211>  372
<212>  DNA
<213>  Listeria monocytogene prophage


<220>
<221>  CDS
<222>  (1)..(372)
<223>  AcrIIA2 gene encoding an acrIIA2 anti-CRISPR protein

<400>  146
atg aca tta aca aga gca caa aaa aag tat gca gaa gcg atg cac gag         48
Met Thr Leu Thr Arg Ala Gln Lys Lys Tyr Ala Glu Ala Met His Glu           
1               5                   10                  15                

ttt ata aat atg gtg gat gac ttt gaa gag tct aca ccg gat ttt gca         96
Phe Ile Asn Met Val Asp Asp Phe Glu Glu Ser Thr Pro Asp Phe Ala           
            20                  25                  30                    

aag gaa gtt cta cat gat tct gac tat gta gtt att aca aaa aat gaa        144
Lys Glu Val Leu His Asp Ser Asp Tyr Val Val Ile Thr Lys Asn Glu           
        35                  40                  45                        

aaa tat gca gta gct ctt tgc tct ctt agc act gat gaa tgt gaa tat        192
Lys Tyr Ala Val Ala Leu Cys Ser Leu Ser Thr Asp Glu Cys Glu Tyr           
    50                  55                  60                            

gat act aac tta tac tta gat gaa aaa ttg gtt gat tac tca aca gtt        240
Asp Thr Asn Leu Tyr Leu Asp Glu Lys Leu Val Asp Tyr Ser Thr Val           
65                  70                  75                  80            

gac gta aac ggt gtg aca tac tac atc aac att gtt gaa act aac gat        288
Asp Val Asn Gly Val Thr Tyr Tyr Ile Asn Ile Val Glu Thr Asn Asp           
                85                  90                  95                

atc gat gat tta gaa atc gct acg gat gaa gat gag atg aaa agt ggc        336
Ile Asp Asp Leu Glu Ile Ala Thr Asp Glu Asp Glu Met Lys Ser Gly           
            100                 105                 110                   

aac caa gaa att att tta aaa agt gag ttg aag taa                        372
Asn Gln Glu Ile Ile Leu Lys Ser Glu Leu Lys                               
        115                 120                                           


<210>  147
<211>  123
<212>  PRT
<213>  Listeria monocytogene prophage

<400>  147

Met Thr Leu Thr Arg Ala Gln Lys Lys Tyr Ala Glu Ala Met His Glu 
1               5                   10                  15      


Phe Ile Asn Met Val Asp Asp Phe Glu Glu Ser Thr Pro Asp Phe Ala 
            20                  25                  30          


Lys Glu Val Leu His Asp Ser Asp Tyr Val Val Ile Thr Lys Asn Glu 
        35                  40                  45              


Lys Tyr Ala Val Ala Leu Cys Ser Leu Ser Thr Asp Glu Cys Glu Tyr 
    50                  55                  60                  


Asp Thr Asn Leu Tyr Leu Asp Glu Lys Leu Val Asp Tyr Ser Thr Val 
65                  70                  75                  80  


Asp Val Asn Gly Val Thr Tyr Tyr Ile Asn Ile Val Glu Thr Asn Asp 
                85                  90                  95      


Ile Asp Asp Leu Glu Ile Ala Thr Asp Glu Asp Glu Met Lys Ser Gly 
            100                 105                 110         


Asn Gln Glu Ile Ile Leu Lys Ser Glu Leu Lys 
        115                 120             


<210>  148
<211>  64
<212>  DNA
<213>  Synthetic


<220>
<221>  promoter
<222>  (1)..(35)
<223>  Constitutive promoter BBaJ23100

<400>  148
ttgacggcta gctcagtcct aggtacagtg ctagctacta gagaagtcta gcgaaccgca       60

ctta                                                                    64


<210>  149
<211>  81
<212>  DNA
<213>  Synthetic


<220>
<221>  misc_structure
<222>  (1)..(81)
<223>  DNA sequence theophyllin riboswitch

<400>  149
atacgactca ctataggtac cggtgatacc agcatcgtct tgatgccctt ggcagcaccc       60

tgctaaggta acaacaagat g                                                 81


<210>  150
<211>  4107
<212>  DNA
<213>  Streptococcus pyogenes


<220>
<221>  CDS
<222>  (1)..(4107)
<223>  Cas9 gene

<400>  150
atg gat aag aaa tac tca ata ggc tta gat atc ggc aca aat agc gtc         48
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val           
1               5                   10                  15                

gga tgg gcg gtg atc act gat gaa tat aag gtt ccg tct aaa aag ttc         96
Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe           
            20                  25                  30                    

aag gtt ctg gga aat aca gac cgc cac agt atc aaa aaa aat ctt ata        144
Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile           
        35                  40                  45                        

ggg gct ctt tta ttt gac agt gga gag aca gcg gaa gcg act cgt ctc        192
Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu           
    50                  55                  60                            

aaa cgg aca gct cgt aga agg tat aca cgt cgg aag aat cgt att tgt        240
Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys           
65                  70                  75                  80            

tat cta cag gag att ttt tca aat gag atg gcg aaa gta gat gat agt        288
Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser           
                85                  90                  95                

ttc ttt cat cga ctt gaa gag tct ttt ttg gtg gaa gaa gac aag aag        336
Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys           
            100                 105                 110                   

cat gaa cgt cat cct att ttt gga aat ata gta gat gaa gtt gct tat        384
His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr           
        115                 120                 125                       

cat gag aaa tat cca act atc tat cat ctg cga aaa aaa ttg gta gat        432
His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp           
    130                 135                 140                           

tct act gat aaa gcg gat ttg cgc tta atc tat ttg gcc tta gcg cat        480
Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His           
145                 150                 155                 160           

atg att aag ttt cgt ggt cat ttt ttg att gag gga gat tta aat cct        528
Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro           
                165                 170                 175               

gat aat agt gat gtg gac aaa cta ttt atc cag ttg gta caa acc tac        576
Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr           
            180                 185                 190                   

aat caa tta ttt gaa gaa aac cct att aac gca agt gga gta gat gct        624
Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala           
        195                 200                 205                       

aaa gcg att ctt tct gca cga ttg agt aaa tca aga cga tta gaa aat        672
Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn           
    210                 215                 220                           

ctc att gct cag ctc ccc ggt gag aag aaa aat ggc tta ttt ggg aat        720
Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn           
225                 230                 235                 240           

ctc att gct ttg tca ttg ggt ttg acc cct aat ttt aaa tca aat ttt        768
Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe           
                245                 250                 255               

gat ttg gca gaa gat gct aaa tta cag ctt tca aaa gat act tac gat        816
Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp           
            260                 265                 270                   

gat gat tta gat aat tta ttg gcg caa att gga gat caa tat gct gat        864
Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp           
        275                 280                 285                       

ttg ttt ttg gca gct aag aat tta tca gat gct att tta ctt tca gat        912
Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp           
    290                 295                 300                           

atc cta aga gta aat act gaa ata act aag gct ccc cta tca gct tca        960
Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser           
305                 310                 315                 320           

atg att aaa cgc tac gat gaa cat cat caa gac ttg act ctt tta aaa       1008
Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys           
                325                 330                 335               

gct tta gtt cga caa caa ctt cca gaa aag tat aaa gaa atc ttt ttt       1056
Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe           
            340                 345                 350                   

gat caa tca aaa aac gga tat gca ggt tat att gat ggg gga gct agc       1104
Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser           
        355                 360                 365                       

caa gaa gaa ttt tat aaa ttt atc aaa cca att tta gaa aaa atg gat       1152
Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp           
    370                 375                 380                           

ggt act gag gaa tta ttg gtg aaa cta aat cgt gaa gat ttg ctg cgc       1200
Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg           
385                 390                 395                 400           

aag caa cgg acc ttt gac aac ggc tct att ccc cat caa att cac ttg       1248
Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu           
                405                 410                 415               

ggt gag ctg cat gct att ttg aga aga caa gaa gac ttt tat cca ttt       1296
Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe           
            420                 425                 430                   

tta aaa gac aat cgt gag aag att gaa aaa atc ttg act ttt cga att       1344
Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile           
        435                 440                 445                       

cct tat tat gtt ggt cca ttg gcg cgt ggc aat agt cgt ttt gca tgg       1392
Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp           
    450                 455                 460                           

atg act cgg aag tct gaa gaa aca att acc cca tgg aat ttt gaa gaa       1440
Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu           
465                 470                 475                 480           

gtt gtc gat aaa ggt gct tca gct caa tca ttt att gaa cgc atg aca       1488
Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr           
                485                 490                 495               

aac ttt gat aaa aat ctt cca aat gaa aaa gta cta cca aaa cat agt       1536
Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser           
            500                 505                 510                   

ttg ctt tat gag tat ttt acg gtt tat aac gaa ttg aca aag gtc aaa       1584
Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys           
        515                 520                 525                       

tat gtt act gaa gga atg cga aaa cca gca ttt ctt tca ggt gaa cag       1632
Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln           
    530                 535                 540                           

aag aaa gcc att gtt gat tta ctc ttc aaa aca aat cga aaa gta acc       1680
Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr           
545                 550                 555                 560           

gtt aag caa tta aaa gaa gat tat ttc aaa aaa ata gaa tgt ttt gat       1728
Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp           
                565                 570                 575               

agt gtt gaa att tca gga gtt gaa gat aga ttt aat gct tca tta ggt       1776
Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly           
            580                 585                 590                   

acc tac cat gat ttg cta aaa att att aaa gat aaa gat ttt ttg gat       1824
Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp           
        595                 600                 605                       

aat gaa gaa aat gaa gat atc tta gag gat att gtt tta aca ttg acc       1872
Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr           
    610                 615                 620                           

tta ttt gaa gat agg gag atg att gag gaa aga ctt aaa aca tat gct       1920
Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala           
625                 630                 635                 640           

cac ctc ttt gat gat aag gtg atg aaa cag ctt aaa cgt cgc cgt tat       1968
His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr           
                645                 650                 655               

act ggt tgg gga cgt ttg tct cga aaa ttg att aat ggt att agg gat       2016
Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp           
            660                 665                 670                   

aag caa tct ggc aaa aca ata tta gat ttt ttg aaa tca gat ggt ttt       2064
Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe           
        675                 680                 685                       

gcc aat cgc aat ttt atg cag ctg atc cat gat gat agt ttg aca ttt       2112
Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe           
    690                 695                 700                           

aaa gaa gac att caa aaa gca caa gtg tct gga caa ggc gat agt tta       2160
Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu           
705                 710                 715                 720           

cat gaa cat att gca aat tta gct ggt agc cct gct att aaa aaa ggt       2208
His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly           
                725                 730                 735               

att tta cag act gta aaa gtt gtt gat gaa ttg gtc aaa gta atg ggg       2256
Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly           
            740                 745                 750                   

cgg cat aag cca gaa aat atc gtt att gaa atg gca cgt gaa aat cag       2304
Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln           
        755                 760                 765                       

aca act caa aag ggc cag aaa aat tcg cga gag cgt atg aaa cga atc       2352
Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile           
    770                 775                 780                           

gaa gaa ggt atc aaa gaa tta gga agt cag att ctt aaa gag cat cct       2400
Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro           
785                 790                 795                 800           

gtt gaa aat act caa ttg caa aat gaa aag ctc tat ctc tat tat ctc       2448
Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu           
                805                 810                 815               

caa aat gga aga gac atg tat gtg gac caa gaa tta gat att aat cgt       2496
Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg           
            820                 825                 830                   

tta agt gat tat gat gtc gat cac att gtt cca caa agt ttc ctt aaa       2544
Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys           
        835                 840                 845                       

gac gat tca ata gac aat aag gtc tta acg cgt tct gat aaa aat cgt       2592
Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg           
    850                 855                 860                           

ggt aaa tcg gat aac gtt cca agt gaa gaa gta gtc aaa aag atg aaa       2640
Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys           
865                 870                 875                 880           

aac tat tgg aga caa ctt cta aac gcc aag tta atc act caa cgt aag       2688
Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys           
                885                 890                 895               

ttt gat aat tta acg aaa gct gaa cgt gga ggt ttg agt gaa ctt gat       2736
Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp           
            900                 905                 910                   

aaa gct ggt ttt atc aaa cgc caa ttg gtt gaa act cgc caa atc act       2784
Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr           
        915                 920                 925                       

aag cat gtg gca caa att ttg gat agt cgc atg aat act aaa tac gat       2832
Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp           
    930                 935                 940                           

gaa aat gat aaa ctt att cga gag gtt aaa gtg att acc tta aaa tct       2880
Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser           
945                 950                 955                 960           

aaa tta gtt tct gac ttc cga aaa gat ttc caa ttc tat aaa gta cgt       2928
Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg           
                965                 970                 975               

gag att aac aat tac cat cat gcc cat gat gcg tat cta aat gcc gtc       2976
Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val           
            980                 985                 990                   

gtt gga act gct ttg att aag aaa  tat cca aaa ctt gaa  tcg gag ttt     3024
Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe         
        995                 1000                 1005                     

gtc tat  ggt gat tat aaa gtt  tat gat gtt cgt aaa  atg att gct        3069
Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala            
    1010                 1015                 1020                        

aag tct  gag caa gaa ata ggc  aaa gca acc gca aaa  tat ttc ttt        3114
Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe            
    1025                 1030                 1035                        

tac tct  aat atc atg aac ttc  ttc aaa aca gaa att  aca ctt gca        3159
Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala            
    1040                 1045                 1050                        

aat gga  gag att cgc aaa cgc  cct cta atc gaa act  aat ggg gaa        3204
Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu            
    1055                 1060                 1065                        

act gga  gaa att gtc tgg gat  aaa ggg cga gat ttt  gcc aca gtg        3249
Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val            
    1070                 1075                 1080                        

cgc aaa  gta ttg tcc atg ccc  caa gtc aat att gtc  aag aaa aca        3294
Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr            
    1085                 1090                 1095                        

gaa gta  cag aca ggc gga ttc  tcc aag gag tca att  tta cca aaa        3339
Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys            
    1100                 1105                 1110                        

aga aat  tcg gac aag ctt att  gct cgt aaa aaa gac  tgg gat cca        3384
Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro            
    1115                 1120                 1125                        

aaa aaa  tat ggt ggt ttt gat  agt cca acg gta gct  tat tca gtc        3429
Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val            
    1130                 1135                 1140                        

cta gtg  gtt gct aag gtg gaa  aaa ggg aaa tcg aag  aag tta aaa        3474
Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys            
    1145                 1150                 1155                        

tcc gtt  aaa gag tta cta ggg  atc aca att atg gaa  aga agt tcc        3519
Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser            
    1160                 1165                 1170                        

ttt gaa  aaa aat ccg att gac  ttt tta gaa gct aaa  gga tat aag        3564
Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys            
    1175                 1180                 1185                        

gaa gtt  aaa aaa gac tta atc  att aaa cta cct aaa  tat agt ctt        3609
Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu            
    1190                 1195                 1200                        

ttt gag  tta gaa aac ggt cgt  aaa cgg atg ctg gct  agt gcc gga        3654
Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly            
    1205                 1210                 1215                        

gaa tta  caa aaa gga aat gag  ctg gct ctg cca agc  aaa tat gtg        3699
Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val            
    1220                 1225                 1230                        

aat ttt  tta tat tta gct agt  cat tat gaa aag ttg  aag ggt agt        3744
Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser            
    1235                 1240                 1245                        

cca gaa  gat aac gaa caa aaa  caa ttg ttt gtg gag  cag cat aag        3789
Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys            
    1250                 1255                 1260                        

cat tat  tta gat gag att att  gag caa atc agt gaa  ttt tct aag        3834
His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys            
    1265                 1270                 1275                        

cgt gtt  att tta gca gat gcc  aat tta gat aaa gtt  ctt agt gca        3879
Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala            
    1280                 1285                 1290                        

tat aac  aaa cat aga gac aaa  cca ata cgt gaa caa  gca gaa aat        3924
Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn            
    1295                 1300                 1305                        

att att  cat tta ttt acg ttg  acg aat ctt gga gct  ccc gct gct        3969
Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala            
    1310                 1315                 1320                        

ttt aaa  tat ttt gat aca aca  att gat cgt aaa cga  tat acg tct        4014
Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser            
    1325                 1330                 1335                        

aca aaa  gaa gtt tta gat gcc  act ctt atc cat caa  tcc atc act        4059
Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr            
    1340                 1345                 1350                        

ggt ctt  tat gaa aca cgc att  gat ttg agt cag cta  gga ggt gac        4104
Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp            
    1355                 1360                 1365                        

tga                                                                   4107


<210>  151
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  151

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  152
<211>  42
<212>  DNA
<213>  Streptococcus pyogenes


<220>
<221>  terminator
<222>  (1)..(42)
<223>  Native terminator for Cas9 gene

<400>  152
aaaaaaacaa gcgctttcaa aacgcttgtt ttatcatttt ta                          42


<210>  153
<211>  789
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(789)
<223>  aadA spectinomycin resistance gene

<400>  153
atg agg gaa gcg gtg atc gcc gaa gta tcg act caa cta tca gag gta         48
Met Arg Glu Ala Val Ile Ala Glu Val Ser Thr Gln Leu Ser Glu Val           
1               5                   10                  15                

gtt ggc gtc atc gag cgc cat ctc gaa ccg acg ttg ctg gcc gta cat         96
Val Gly Val Ile Glu Arg His Leu Glu Pro Thr Leu Leu Ala Val His           
            20                  25                  30                    

ttg tac ggc tcc gca gtg gat ggc ggc ctg aag cca cac agt gat att        144
Leu Tyr Gly Ser Ala Val Asp Gly Gly Leu Lys Pro His Ser Asp Ile           
        35                  40                  45                        

gat ttg ctg gtt acg gtg acc gta agg ctt gat gaa aca acg cgg cga        192
Asp Leu Leu Val Thr Val Thr Val Arg Leu Asp Glu Thr Thr Arg Arg           
    50                  55                  60                            

gct ttg atc aac gac ctt ttg gaa act tcg gct tcc cct gga gag agc        240
Ala Leu Ile Asn Asp Leu Leu Glu Thr Ser Ala Ser Pro Gly Glu Ser           
65                  70                  75                  80            

gag att ctc cgc gct gta gaa gtc acc att gtt gtg cac gac gac atc        288
Glu Ile Leu Arg Ala Val Glu Val Thr Ile Val Val His Asp Asp Ile           
                85                  90                  95                

att ccg tgg cgt tat cca gct aag cgc gaa ctg caa ttt gga gaa tgg        336
Ile Pro Trp Arg Tyr Pro Ala Lys Arg Glu Leu Gln Phe Gly Glu Trp           
            100                 105                 110                   

cag cgc aat gac att ctt gca ggt atc ttc gag cca gcc acg atc gac        384
Gln Arg Asn Asp Ile Leu Ala Gly Ile Phe Glu Pro Ala Thr Ile Asp           
        115                 120                 125                       

att gat ctg gct atc ttg ctg aca aaa gca aga gaa cat agc gtt gcc        432
Ile Asp Leu Ala Ile Leu Leu Thr Lys Ala Arg Glu His Ser Val Ala           
    130                 135                 140                           

ttg gta ggt cca gcg gcg gag gaa ctc ttt gat ccg gtt cct gaa cag        480
Leu Val Gly Pro Ala Ala Glu Glu Leu Phe Asp Pro Val Pro Glu Gln           
145                 150                 155                 160           

gat cta ttt gag gcg cta aat gaa acc tta acg cta tgg aac tcg ccg        528
Asp Leu Phe Glu Ala Leu Asn Glu Thr Leu Thr Leu Trp Asn Ser Pro           
                165                 170                 175               

ccc gac tgg gct ggc gat gag cga aat gta gtg ctt acg ttg tcc cgc        576
Pro Asp Trp Ala Gly Asp Glu Arg Asn Val Val Leu Thr Leu Ser Arg           
            180                 185                 190                   

att tgg tac agc gca gta acc ggc aaa atc gcg ccg aag gat gtc gct        624
Ile Trp Tyr Ser Ala Val Thr Gly Lys Ile Ala Pro Lys Asp Val Ala           
        195                 200                 205                       

gcc gac tgg gca atg gag cgc ctg ccg gcc cag tat cag ccc gtc ata        672
Ala Asp Trp Ala Met Glu Arg Leu Pro Ala Gln Tyr Gln Pro Val Ile           
    210                 215                 220                           

ctt gaa gct aga cag gct tat ctt gga caa gaa gaa gat cgc ttg gcc        720
Leu Glu Ala Arg Gln Ala Tyr Leu Gly Gln Glu Glu Asp Arg Leu Ala           
225                 230                 235                 240           

tcg cgc gca gat cag ttg gaa gaa ttt gtc cac tac gtg aaa ggc gag        768
Ser Arg Ala Asp Gln Leu Glu Glu Phe Val His Tyr Val Lys Gly Glu           
                245                 250                 255               

atc acc aag gta gtc ggc aaa                                            789
Ile Thr Lys Val Val Gly Lys                                               
            260                                                           


<210>  154
<211>  263
<212>  PRT
<213>  Escherichia coli

<400>  154

Met Arg Glu Ala Val Ile Ala Glu Val Ser Thr Gln Leu Ser Glu Val 
1               5                   10                  15      


Val Gly Val Ile Glu Arg His Leu Glu Pro Thr Leu Leu Ala Val His 
            20                  25                  30          


Leu Tyr Gly Ser Ala Val Asp Gly Gly Leu Lys Pro His Ser Asp Ile 
        35                  40                  45              


Asp Leu Leu Val Thr Val Thr Val Arg Leu Asp Glu Thr Thr Arg Arg 
    50                  55                  60                  


Ala Leu Ile Asn Asp Leu Leu Glu Thr Ser Ala Ser Pro Gly Glu Ser 
65                  70                  75                  80  


Glu Ile Leu Arg Ala Val Glu Val Thr Ile Val Val His Asp Asp Ile 
                85                  90                  95      


Ile Pro Trp Arg Tyr Pro Ala Lys Arg Glu Leu Gln Phe Gly Glu Trp 
            100                 105                 110         


Gln Arg Asn Asp Ile Leu Ala Gly Ile Phe Glu Pro Ala Thr Ile Asp 
        115                 120                 125             


Ile Asp Leu Ala Ile Leu Leu Thr Lys Ala Arg Glu His Ser Val Ala 
    130                 135                 140                 


Leu Val Gly Pro Ala Ala Glu Glu Leu Phe Asp Pro Val Pro Glu Gln 
145                 150                 155                 160 


Asp Leu Phe Glu Ala Leu Asn Glu Thr Leu Thr Leu Trp Asn Ser Pro 
                165                 170                 175     


Pro Asp Trp Ala Gly Asp Glu Arg Asn Val Val Leu Thr Leu Ser Arg 
            180                 185                 190         


Ile Trp Tyr Ser Ala Val Thr Gly Lys Ile Ala Pro Lys Asp Val Ala 
        195                 200                 205             


Ala Asp Trp Ala Met Glu Arg Leu Pro Ala Gln Tyr Gln Pro Val Ile 
    210                 215                 220                 


Leu Glu Ala Arg Gln Ala Tyr Leu Gly Gln Glu Glu Asp Arg Leu Ala 
225                 230                 235                 240 


Ser Arg Ala Asp Gln Leu Glu Glu Phe Val His Tyr Val Lys Gly Glu 
                245                 250                 255     


Ile Thr Lys Val Val Gly Lys 
            260             


<210>  155
<211>  1221
<212>  DNA
<213>  Synthetic


<220>
<221>  rep_origin
<222>  (1)..(1221)
<223>  pSC101 origin of replication

<400>  155
gagttataca cagggctggg atctattctt tttatctttt tttattcttt ctttattcta       60

taaattataa ccacttgaat ataaacaaaa aaaacacaca aaggtctagc ggaatttaca      120

gagggtctag cagaatttac aagttttcca gcaaaggtct agcagaattt acagataccc      180

acaactcaaa ggaaaaggac atgtaattat cattgactag cccatctcaa ttggtatagt      240

gattaaaatc acctagacca attgagatgt atgtctgaat tagttgtttt caaagcaaat      300

gaactagcga ttagtcgcta tgacttaacg gagcatgaaa ccaagctaat tttatgctgt      360

gtggcactac tcaaccccac gattgaaaac cctacaagga aagaacggac ggtatcgttc      420

acttataacc aatacgctca gatgatgaac atcagtaggg aaaatgctta tggtgtatta      480

gctaaagcaa ccagagagct gatgacgaga actgtggaaa tcaggaatcc tttggttaaa      540

ggctttgaga ttttccagtg gacaaactat gccaagttct caagcgaaaa attagaatta      600

gtttttagtg aagagatatt gccttatctt ttccagttaa aaaaattcat aaaatataat      660

ctggaacatg ttaagtcttt tgaaaacaaa tactctatga ggatttatga gtggttatta      720

aaagaactaa cacaaaagaa aactcacaag gcaaatatag agattagcct tgatgaattt      780

aagttcatgt taatgcttga aaataactac catgagttta aaaggcttaa ccaatgggtt      840

ttgaaaccaa taagtaaaga tttaaacact tacagcaata tgaaattggt ggttgataag      900

cgaggccgcc cgactgatac gttgattttc caagttgaac tagatagaca aatggatctc      960

gtaaccgaac ttgagaacaa ccagataaaa atgaatggtg acaaaatacc aacaaccatt     1020

acatcagatt cctacctaca taacggacta agaaaaacac tacacgatgc tttaactgca     1080

aaaattcagc tcaccagttt tgaggcaaaa tttttgagtg acatgcaaag taagtatgat     1140

ctcaatggtt cgttctcatg gctcacgcaa aaacaacgaa ccacactaga gaacatactg     1200

gctaaatacg gaaggatctg a                                               1221


<210>  156
<211>  140
<212>  DNA
<213>  Streptococcus pyogenes


<220>
<221>  primer_bind
<222>  (1)..(140)
<223>  Forward primer for Cas9 gene

<400>  156
aagtctagcg aaccgcactt aatacgactc actataggta ccggtgatac cagcatcgtc       60

ttgatgccct tggcagcacc ctgctaaggt aacaacaaga tgatggataa gaaatactca      120

ataggcttag atatcggcac                                                  140


<210>  157
<211>  69
<212>  DNA
<213>  Streptococcus pyogenes


<220>
<221>  primer_bind
<222>  (1)..(69)
<223>  Reverse primer for Cas9 gene

<400>  157
ctctagtagc tagcactgta cctaggactg agctagccgt caagttagct gtgctctaga       60

agctagcag                                                               69


<210>  158
<211>  311
<212>  DNA
<213>  Synthetic


<220>
<221>  promoter
<222>  (1)..(311)
<223>  pBAD arabinose inducible promoter

<400>  158
acttttcata ctcccgccat tcagagaaga aaccaattgt ccatattgca tcagacattg       60

ccgtcactgc gtcttttact ggctcttctc gctaaccaaa ccggtaaccc cgcttattaa      120

aagcattctg taacaaagcg ggaccaaagc catgacaaaa acgcgtaaca aaagtgtcta      180

taatcacggc agaaaagtcc acattgatta tttgcacggc gtcacacttt gctatgccat      240

agcattttta tccataagat tagcggatcc tacctgacgc tttttatcgc aactctctac      300

tgtttctcca t                                                           311


<210>  159
<211>  879
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(879)
<223>  AraC gene encoding arabinose-inducible transcription factor

<400>  159
atg gct gaa gcg caa aat gat ccc ctg ctg ccg gga tac tcg ttt aat         48
Met Ala Glu Ala Gln Asn Asp Pro Leu Leu Pro Gly Tyr Ser Phe Asn           
1               5                   10                  15                

gcc cat ctg gtg gcg ggt tta acg ccg att gag gcc aac ggt tat ctc         96
Ala His Leu Val Ala Gly Leu Thr Pro Ile Glu Ala Asn Gly Tyr Leu           
            20                  25                  30                    

gat ttt ttt atc gac cga ccg ctg gga atg aaa ggt tat att ctc aat        144
Asp Phe Phe Ile Asp Arg Pro Leu Gly Met Lys Gly Tyr Ile Leu Asn           
        35                  40                  45                        

ctc acc att cgc ggt cag ggg gtg gtg aaa aat cag gga cga gaa ttt        192
Leu Thr Ile Arg Gly Gln Gly Val Val Lys Asn Gln Gly Arg Glu Phe           
    50                  55                  60                            

gtt tgc cga ccg ggt gat att ttg ctg ttc ccg cca gga gag att cat        240
Val Cys Arg Pro Gly Asp Ile Leu Leu Phe Pro Pro Gly Glu Ile His           
65                  70                  75                  80            

cac tac ggt cgt cat ccg gag gct cgc gaa tgg tat cac cag tgg gtt        288
His Tyr Gly Arg His Pro Glu Ala Arg Glu Trp Tyr His Gln Trp Val           
                85                  90                  95                

tac ttt cgt ccg cgc gcc tac tgg cat gaa tgg ctt aac tgg ccg tca        336
Tyr Phe Arg Pro Arg Ala Tyr Trp His Glu Trp Leu Asn Trp Pro Ser           
            100                 105                 110                   

ata ttt gcc aat acg ggg ttc ttt cgc ccg gat gaa gcg cac cag ccg        384
Ile Phe Ala Asn Thr Gly Phe Phe Arg Pro Asp Glu Ala His Gln Pro           
        115                 120                 125                       

cat ttc agc gac ctg ttt ggg caa atc att aac gcc ggg caa ggg gaa        432
His Phe Ser Asp Leu Phe Gly Gln Ile Ile Asn Ala Gly Gln Gly Glu           
    130                 135                 140                           

ggg cgc tat tcg gag ctg ctg gcg ata aat ctg ctt gag caa ttg tta        480
Gly Arg Tyr Ser Glu Leu Leu Ala Ile Asn Leu Leu Glu Gln Leu Leu           
145                 150                 155                 160           

ctg cgg cgc atg gaa gcg att aac gag tcg ctc cat cca ccg atg gat        528
Leu Arg Arg Met Glu Ala Ile Asn Glu Ser Leu His Pro Pro Met Asp           
                165                 170                 175               

aat cgg gta cgc gag gct tgt cag tac atc agc gat cac ctg gca gac        576
Asn Arg Val Arg Glu Ala Cys Gln Tyr Ile Ser Asp His Leu Ala Asp           
            180                 185                 190                   

agc aat ttt gat atc gcc agc gtc gca cag cat gtt tgc ttg tcg ccg        624
Ser Asn Phe Asp Ile Ala Ser Val Ala Gln His Val Cys Leu Ser Pro           
        195                 200                 205                       

tcg cgt ctg tca cat ctt ttc cgc cag cag tta ggg att agc gtc tta        672
Ser Arg Leu Ser His Leu Phe Arg Gln Gln Leu Gly Ile Ser Val Leu           
    210                 215                 220                           

agc tgg cgc gag gac caa cgt atc agc cag gcg aag ctg ctt ttg agc        720
Ser Trp Arg Glu Asp Gln Arg Ile Ser Gln Ala Lys Leu Leu Leu Ser           
225                 230                 235                 240           

acc acc cgg atg cct atc gcc acc gtc ggt cgc aat gtt ggt ttt gac        768
Thr Thr Arg Met Pro Ile Ala Thr Val Gly Arg Asn Val Gly Phe Asp           
                245                 250                 255               

gat caa ctc tat ttc tcg cgg gta ttt aaa aaa tgc acc ggg gcc agc        816
Asp Gln Leu Tyr Phe Ser Arg Val Phe Lys Lys Cys Thr Gly Ala Ser           
            260                 265                 270                   

ccg agc gag ttc cgt gcc ggt tgt gaa gaa aaa gtg aat gat gta gcc        864
Pro Ser Glu Phe Arg Ala Gly Cys Glu Glu Lys Val Asn Asp Val Ala           
        275                 280                 285                       

gtc aag ttg tca taa                                                    879
Val Lys Leu Ser                                                           
    290                                                                   


<210>  160
<211>  292
<212>  PRT
<213>  Escherichia coli

<400>  160

Met Ala Glu Ala Gln Asn Asp Pro Leu Leu Pro Gly Tyr Ser Phe Asn 
1               5                   10                  15      


Ala His Leu Val Ala Gly Leu Thr Pro Ile Glu Ala Asn Gly Tyr Leu 
            20                  25                  30          


Asp Phe Phe Ile Asp Arg Pro Leu Gly Met Lys Gly Tyr Ile Leu Asn 
        35                  40                  45              


Leu Thr Ile Arg Gly Gln Gly Val Val Lys Asn Gln Gly Arg Glu Phe 
    50                  55                  60                  


Val Cys Arg Pro Gly Asp Ile Leu Leu Phe Pro Pro Gly Glu Ile His 
65                  70                  75                  80  


His Tyr Gly Arg His Pro Glu Ala Arg Glu Trp Tyr His Gln Trp Val 
                85                  90                  95      


Tyr Phe Arg Pro Arg Ala Tyr Trp His Glu Trp Leu Asn Trp Pro Ser 
            100                 105                 110         


Ile Phe Ala Asn Thr Gly Phe Phe Arg Pro Asp Glu Ala His Gln Pro 
        115                 120                 125             


His Phe Ser Asp Leu Phe Gly Gln Ile Ile Asn Ala Gly Gln Gly Glu 
    130                 135                 140                 


Gly Arg Tyr Ser Glu Leu Leu Ala Ile Asn Leu Leu Glu Gln Leu Leu 
145                 150                 155                 160 


Leu Arg Arg Met Glu Ala Ile Asn Glu Ser Leu His Pro Pro Met Asp 
                165                 170                 175     


Asn Arg Val Arg Glu Ala Cys Gln Tyr Ile Ser Asp His Leu Ala Asp 
            180                 185                 190         


Ser Asn Phe Asp Ile Ala Ser Val Ala Gln His Val Cys Leu Ser Pro 
        195                 200                 205             


Ser Arg Leu Ser His Leu Phe Arg Gln Gln Leu Gly Ile Ser Val Leu 
    210                 215                 220                 


Ser Trp Arg Glu Asp Gln Arg Ile Ser Gln Ala Lys Leu Leu Leu Ser 
225                 230                 235                 240 


Thr Thr Arg Met Pro Ile Ala Thr Val Gly Arg Asn Val Gly Phe Asp 
                245                 250                 255     


Asp Gln Leu Tyr Phe Ser Arg Val Phe Lys Lys Cys Thr Gly Ala Ser 
            260                 265                 270         


Pro Ser Glu Phe Arg Ala Gly Cys Glu Glu Lys Val Asn Asp Val Ala 
        275                 280                 285             


Val Lys Leu Ser 
    290         


<210>  161
<211>  103
<212>  DNA
<213>  Synthetic


<220>
<221>  Unsure
<222>  (1)..(103)
<223>  DNA for gRNA_Cas9 transcript targeting camR gene

<400>  161
ctataaccag accgttcagc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt ttt                        103


<210>  162
<211>  365
<212>  DNA
<213>  Synthetic


<220>
<221>  terminator
<222>  (1)..(365)
<223>  TrrnB terminator for DNA coding gRNA_Cas9 transcript

<400>  162
gaagcttggg cccgaacaaa aactcatctc agaagaggat ctgaatagcg ccgtcgacca       60

tcatcatcat cattgagttt aaacggtctc cagcttggct gttttggcgg atgagagaag      120

attttcagcc tgatacagat taaatcagaa cgcagaagcg gtctgataaa acagaatttg      180

cctggcggca gtagcgcggt ggtcccacct gaccccatgc cgaactcaga agtgaaacgc      240

cgtagcgccg atggtagtgt ggggtctccc catgcgagag tagggaactg ccaggcatca      300

aataaaacga aaggctcagt cgaaagactg ggcctttcgt tttatctgtt gtttgtcggt      360

gaact                                                                  365


<210>  163
<211>  718
<212>  DNA
<213>  Synthetic


<220>
<221>  rep_origin
<222>  (1)..(718)
<223>  p15A origin of replication

<400>  163
ttaataagat gatcttcttg agatcgtttt ggtctgcgcg taatctcttg ctctgaaaac       60

gaaaaaaccg ccttgcaggg cggtttttcg aaggttctct gagctaccaa ctctttgaac      120

cgaggtaact ggcttggagg agcgcagtca ccaaaacttg tcctttcagt ttagccttaa      180

ccggcgcatg acttcaagac taactcctct aaatcaatta ccagtggctg ctgccagtgg      240

tgcttttgca tgtctttccg ggttggactc aagacgatag ttaccggata aggcgcagcg      300

gtcggactga acggggggtt cgtgcataca gtccagcttg gagcgaactg cctacccgga      360

actgagtgtc aggcgtggaa tgagacaaac gcggccataa cagcggaatg acaccggtaa      420

accgaaaggc aggaacagga gagcgcacga gggagccgcc agggggaaac gcctggtatc      480

tttatagtcc tgtcgggttt cgccaccact gatttgagcg tcagatttcg tgatgcttgt      540

caggggggcg gagcctatgg aaaaacggct ttgccgcggc cctctcactt ccctgttaag      600

tatcttcctg gcatcttcca ggaaatctcc gccccgttcg taagccattt ccgctcgccg      660

cagtcgaacg accgagcgta gcgagtcagt gagcgaggaa gcggaatata tccctagg        718


<210>  164
<211>  657
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(657)
<223>  Chloramphenicol resistance gene

<400>  164
atg gag aaa aaa atc act gga tat acc acc gtt gat ata tcc caa tgg         48
Met Glu Lys Lys Ile Thr Gly Tyr Thr Thr Val Asp Ile Ser Gln Trp           
1               5                   10                  15                

cat cgt aaa gaa cat ttt gag gca ttt cag tca gtt gct caa tgt acc         96
His Arg Lys Glu His Phe Glu Ala Phe Gln Ser Val Ala Gln Cys Thr           
            20                  25                  30                    

tat aac cag acc gtt cag ctg gat att acg gcc ttt tta aag acc gta        144
Tyr Asn Gln Thr Val Gln Leu Asp Ile Thr Ala Phe Leu Lys Thr Val           
        35                  40                  45                        

aag aaa aat aag cac aag ttt tat ccg gcc ttt att cac att ctt gcc        192
Lys Lys Asn Lys His Lys Phe Tyr Pro Ala Phe Ile His Ile Leu Ala           
    50                  55                  60                            

cgc ctg atg aat gct cat ccg gaa ttt cgt atg gca atg aaa gac ggt        240
Arg Leu Met Asn Ala His Pro Glu Phe Arg Met Ala Met Lys Asp Gly           
65                  70                  75                  80            

gag ctg gtg ata tgg gat agt gtt cac cct tgt tac acc gtt ttc cat        288
Glu Leu Val Ile Trp Asp Ser Val His Pro Cys Tyr Thr Val Phe His           
                85                  90                  95                

gag caa act gaa acg ttt tca tcg ctc tgg agt gaa tac cac gac gat        336
Glu Gln Thr Glu Thr Phe Ser Ser Leu Trp Ser Glu Tyr His Asp Asp           
            100                 105                 110                   

ttc cgg cag ttt cta cac ata tat tcg caa gat gtg gcg tgt tac ggt        384
Phe Arg Gln Phe Leu His Ile Tyr Ser Gln Asp Val Ala Cys Tyr Gly           
        115                 120                 125                       

gaa aac ctg gcc tat ttc cct aaa ggg ttt att gag aat atg ttt ttc        432
Glu Asn Leu Ala Tyr Phe Pro Lys Gly Phe Ile Glu Asn Met Phe Phe           
    130                 135                 140                           

gtc tca gcc aat ccc tgg gtg agt ttc acc agt ttt gat tta aac gtg        480
Val Ser Ala Asn Pro Trp Val Ser Phe Thr Ser Phe Asp Leu Asn Val           
145                 150                 155                 160           

gcc aat atg gac aac ttc ttc gcc ccc gtt ttc acc atg ggc aaa tat        528
Ala Asn Met Asp Asn Phe Phe Ala Pro Val Phe Thr Met Gly Lys Tyr           
                165                 170                 175               

tat acg caa ggc gac aag gtg ctg atg ccg ctg gcg att cag gtt cat        576
Tyr Thr Gln Gly Asp Lys Val Leu Met Pro Leu Ala Ile Gln Val His           
            180                 185                 190                   

cat gcc gtt tgt gat ggc ttc cat gtc ggc aga atg ctt aat gaa tta        624
His Ala Val Cys Asp Gly Phe His Val Gly Arg Met Leu Asn Glu Leu           
        195                 200                 205                       

caa cag tac tgc gat gag tgg cag ggc ggg gcg                            657
Gln Gln Tyr Cys Asp Glu Trp Gln Gly Gly Ala                               
    210                 215                                               


<210>  165
<211>  219
<212>  PRT
<213>  Escherichia coli

<400>  165

Met Glu Lys Lys Ile Thr Gly Tyr Thr Thr Val Asp Ile Ser Gln Trp 
1               5                   10                  15      


His Arg Lys Glu His Phe Glu Ala Phe Gln Ser Val Ala Gln Cys Thr 
            20                  25                  30          


Tyr Asn Gln Thr Val Gln Leu Asp Ile Thr Ala Phe Leu Lys Thr Val 
        35                  40                  45              


Lys Lys Asn Lys His Lys Phe Tyr Pro Ala Phe Ile His Ile Leu Ala 
    50                  55                  60                  


Arg Leu Met Asn Ala His Pro Glu Phe Arg Met Ala Met Lys Asp Gly 
65                  70                  75                  80  


Glu Leu Val Ile Trp Asp Ser Val His Pro Cys Tyr Thr Val Phe His 
                85                  90                  95      


Glu Gln Thr Glu Thr Phe Ser Ser Leu Trp Ser Glu Tyr His Asp Asp 
            100                 105                 110         


Phe Arg Gln Phe Leu His Ile Tyr Ser Gln Asp Val Ala Cys Tyr Gly 
        115                 120                 125             


Glu Asn Leu Ala Tyr Phe Pro Lys Gly Phe Ile Glu Asn Met Phe Phe 
    130                 135                 140                 


Val Ser Ala Asn Pro Trp Val Ser Phe Thr Ser Phe Asp Leu Asn Val 
145                 150                 155                 160 


Ala Asn Met Asp Asn Phe Phe Ala Pro Val Phe Thr Met Gly Lys Tyr 
                165                 170                 175     


Tyr Thr Gln Gly Asp Lys Val Leu Met Pro Leu Ala Ile Gln Val His 
            180                 185                 190         


His Ala Val Cys Asp Gly Phe His Val Gly Arg Met Leu Asn Glu Leu 
        195                 200                 205             


Gln Gln Tyr Cys Asp Glu Trp Gln Gly Gly Ala 
    210                 215                 


<210>  166
<211>  20
<212>  DNA
<213>  Synthetic


<220>
<221>  misc_binding
<222>  (1)..(20)
<223>  CmR + strand binding site for gRNA spacer sequence

<400>  166
ctataaccag accgttcagc                                                   20


<210>  167
<211>  160
<212>  DNA
<213>  Synthetic


<220>
<221>  promoter
<222>  (1)..(160)
<223>  ProC synthetic promoter

<400>  167
ttctagagca cagctaacac cacgtcgtcc ctatctgctg ccctaggtct atgagtggtt       60

gctggataac tttacgggca tgcataaggc tcgtatgata tattcaggga gaccacaacg      120

gtttccctct acaaataatt ttgtttaact tttactagag                            160


<210>  168
<211>  1388
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  PEPTIDE
<222>  (1)..(1388)
<223>  CRISPR-associated protein Cas9 2 from Streptococcus thermophilus 
       ABJ66636.1

<400>  168

Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Lys Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Ser Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Thr Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210>  169
<211>  36
<212>  DNA
<213>  Synthetic


<220>
<221>  gene
<222>  (1)..(36)
<223>  DNA coding for Type IIA cognate crRNA repeat sequence_for 
       Streptcoccus thermophilus

<400>  169
gtttttgtac tctcaagatt taagtaactg tacaac                                 36


<210>  170
<211>  211
<212>  DNA
<213>  Synthetic


<220>
<221>  gene
<222>  (1)..(211)
<223>  DNA coding for Type II A cognate tracRNA_ for Streptococcus 
       thermophilus

<400>  170
gcctaagcta gatttttaat attaattgtt agaaagtgtt gcaattatag ttatcatata       60

ctataataat agtgtaaggg acgccttaca cagttactta aatcttgcag aagctacaaa      120

gataaggctt catgccgaaa tcaacaccct gtcattttat ggcagggtgt tttcgttatt      180

taaagaggag aagaaatgac ttggagagtt g                                     211


<210>  171
<211>  35
<212>  DNA
<213>  Synthetic


<220>
<221>  promoter
<222>  (1)..(35)
<223>  J23112 synthetic promoter

<400>  171
ctgatagcta gctcagtcct agggattatg ctagc                                  35


<210>  172
<211>  35
<212>  DNA
<213>  Synthetic


<220>
<221>  promoter
<222>  (1)..(35)
<223>  J23100 synthetic promoter

<400>  172
ttgacggcta gctcagtcct aggtacagtg ctagc                                  35


<210>  173
<211>  35
<212>  DNA
<213>  Synthetic


<220>
<221>  promoter
<222>  (1)..(35)
<223>  J23101 synthetic promoter

<400>  173
tttacagcta gctcagtcct aggtattatg ctagc                                  35


<210>  174
<211>  35
<212>  DNA
<213>  Synthetic


<220>
<221>  promoter
<222>  (1)..(35)
<223>  J23102 synthetic promoter

<400>  174
ttgacagcta gctcagtcct aggtactgtg ctagc                                  35


<210>  175
<211>  35
<212>  DNA
<213>  Synthetic


<220>
<221>  promoter
<222>  (1)..(35)
<223>  J23104 synthetic promoter

<400>  175
ttgacagcta gctcagtcct aggtattgtg ctagc                                  35


<210>  176
<211>  35
<212>  DNA
<213>  Synthetic


<220>
<221>  promoter
<222>  (1)..(35)
<223>  J23116 synthetic promoter

<400>  176
ttgacagcta gctcagtcct agggactatg ctagc                                  35


<210>  177
<211>  35
<212>  DNA
<213>  Synthetic


<220>
<221>  promoter
<222>  (1)..(35)
<223>  J23111 synthetic promoter

<400>  177
ttgacggcta gctcagtcct aggtatagtg ctagc                                  35


