                         SEQUENCE LISTING

<110>  The University of Liverpool
 
<120>  PEPTIDES AND CONJUGATES

<130>  P252861WO

<150>  GB 1817486.2
<151>  2018-10-26

<150>  GB 1805306.6
<151>  2018-03-29

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  660
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ala Leu Met Ala Arg Gly Ala Leu Thr Gly Pro Leu Arg Ala 
1               5                   10                  15      


Leu Cys Leu Leu Gly Cys Leu Leu Ser His Ala Ala Ala Ala Pro Ser 
            20                  25                  30          


Pro Ile Ile Lys Phe Pro Gly Asp Val Ala Pro Lys Thr Asp Lys Glu 
        35                  40                  45              


Leu Ala Val Gln Tyr Leu Asn Thr Phe Tyr Gly Cys Pro Lys Glu Ser 
    50                  55                  60                  


Cys Asn Leu Phe Val Leu Lys Asp Thr Leu Lys Lys Met Gln Lys Phe 
65                  70                  75                  80  


Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn Thr Ile Glu Thr 
                85                  90                  95      


Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala Asn Tyr Asn Phe 
            100                 105                 110         


Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile 
        115                 120                 125             


Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe 
    130                 135                 140                 


Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser 
145                 150                 155                 160 


Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp 
                165                 170                 175     


Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala 
            180                 185                 190         


His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser His Phe Asp 
        195                 200                 205             


Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val Arg Val Lys 
    210                 215                 220                 


Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe 
                245                 250                 255     


Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly 
            260                 265                 270         


Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly 
        275                 280                 285             


Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser 
    290                 295                 300                 


Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr 
305                 310                 315                 320 


Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala 
                325                 330                 335     


Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro 
            340                 345                 350         


Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg 
        355                 360                 365             


Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp 
    370                 375                 380                 


Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val 
385                 390                 395                 400 


Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu His Ser Gln Asp 
                405                 410                 415     


Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys Asn Phe Arg 
            420                 425                 430         


Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr Gly Ala Ser 
        435                 440                 445             


Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr Leu Gly Pro Val 
    450                 455                 460                 


Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly Ile Ala Gln 
465                 470                 475                 480 


Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile Trp Arg Thr 
                485                 490                 495     


Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu Val Ala Thr Phe 
            500                 505                 510         


Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu Ala Pro Gln 
        515                 520                 525             


Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp Ile Tyr Ser 
    530                 535                 540                 


Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr Ser Leu Gly 
545                 550                 555                 560 


Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe Asn Trp Ser Lys 
                565                 570                 575     


Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp Arg Tyr Asn 
            580                 585                 590         


Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu Ile Ala Asp 
        595                 600                 605             


Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val Asp Leu Gln 
    610                 615                 620                 


Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr Leu Lys Leu 
625                 630                 635                 640 


Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys Ser Asp 
                645                 650                 655     


Trp Leu Gly Cys 
            660 


<210>  2
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn Gly Lys Glu 
1               5                   10                  15      


Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe Leu Trp Cys 
            20                  25                  30          


Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly Phe Cys Pro 
        35                  40                  45              


His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly Gln Pro Cys 
    50                  55                  60                  


Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser Cys Thr Thr 
65                  70                  75                  80  


Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr Glu Asp Tyr 
                85                  90                  95      


Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala Met Ser Thr 
            100                 105                 110         


Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro Phe Thr Phe 
        115                 120                 125             


Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg Ser Asp Gly 
    130                 135                 140                 


Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp Arg Lys Trp 
145                 150                 155                 160 


Gly Phe Cys Pro Asp 
                165 


<210>  3
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of peptide comprising the CBD of MMP-2 with 
       additional residues added

<400>  3

Arg Val Lys Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe 
1               5                   10                  15      


Leu Phe Asn Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser 
            20                  25                  30          


Asp Gly Phe Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly 
        35                  40                  45              


Lys Tyr Gly Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn 
    50                  55                  60                  


Ala Glu Gly Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser 
65                  70                  75                  80  


Tyr Asp Ser Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys 
                85                  90                  95      


Gly Thr Thr Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro 
            100                 105                 110         


Glu Thr Ala Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys 
        115                 120                 125             


Val Phe Pro Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser 
    130                 135                 140                 


Ala Gly Arg Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr 
145                 150                 155                 160 


Asp Asp Asp Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser 
                165                 170                 175 


<210>  4
<211>  525
<212>  DNA
<213>  Homo sapiens

<400>  4
cgtgtgaaat atggtaatgc cgatggcgaa tattgcaaat ttccgtttct gtttaacggc       60

aaagagtata atagctgtac cgataccggt cgtagtgatg gttttctgtg gtgtagcacc      120

acctataact ttgagaaaga tggcaaatat ggcttttgtc cgcatgaagc actgtttacc      180

atgggtggta atgcggaagg tcagccgtgt aaatttcctt ttcgctttca gggcaccagc      240

tatgatagtt gtaccaccga aggtcgtacc gatggttatc gttggtgcgg tacaaccgaa      300

gattatgatc gtgacaaaaa atacggtttc tgtccggaaa ccgcaatgag caccgttggt      360

ggtaatagtg aaggtgcacc gtgtgttttt ccgtttacct ttctgggtaa caaatatgaa      420

agctgtacca gtgcaggtcg ttcagatggt aaaatgtggt gcgcaaccac cgcaaattat      480

gatgatgatc gtaaatgggg tttttgccca gatcagggtt atagc                      525


<210>  5
<211>  528
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the CBD of MMP-2 (with stop codon)

<400>  5
cgtgtgaaat atggtaatgc cgatggcgaa tattgcaaat ttccgtttct gtttaacggc       60

aaagagtata atagctgtac cgataccggt cgtagtgatg gttttctgtg gtgtagcacc      120

acctataact ttgagaaaga tggcaaatat ggcttttgtc cgcatgaagc actgtttacc      180

atgggtggta atgcggaagg tcagccgtgt aaatttcctt ttcgctttca gggcaccagc      240

tatgatagtt gtaccaccga aggtcgtacc gatggttatc gttggtgcgg tacaaccgaa      300

gattatgatc gtgacaaaaa atacggtttc tgtccggaaa ccgcaatgag caccgttggt      360

ggtaatagtg aaggtgcacc gtgtgttttt ccgtttacct ttctgggtaa caaatatgaa      420

agctgtacca gtgcaggtcg ttcagatggt aaaatgtggt gcgcaaccac cgcaaattat      480

gatgatgatc gtaaatgggg tttttgccca gatcagggtt atagctaa                   528


<210>  6
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn Gly Lys Glu 
1               5                   10                  15      


Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe Leu Trp Cys 
            20                  25                  30          


Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly Phe Cys Pro 
        35                  40                  45              


His 
    


<210>  7
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence comprising module 1 of the CBD of MMP-2 with 
       additional residues

<400>  7

Val Lys Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu 
1               5                   10                  15      


Phe Asn Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp 
            20                  25                  30          


Gly Phe Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys 
        35                  40                  45              


Tyr Gly Phe Cys Pro His Glu Ala Leu Phe Thr Met 
    50                  55                  60  


<210>  8
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a variant module corresponding to module 1 of the CBD of MMP-2

<400>  8

Val Arg Val Lys Tyr Val Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro 
1               5                   10                  15      


Phe Leu Phe Asn Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg 
            20                  25                  30          


Ser Asp Gly Phe Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp 
        35                  40                  45              


Gly Lys Tyr Gly Phe Cys Pro 
    50                  55  


<210>  9
<211>  180
<212>  DNA
<213>  Homo sapiens

<400>  9
gtgaaatatg gtaatgccga tggcgaatat tgcaaatttc cgtttctgtt taacggcaaa       60

gagtataata gctgtaccga taccggtcgt agtgatggtt ttctgtggtg tagcaccacc      120

tataactttg agaaagatgg caaatatggc ttttgtccgc atgaagcact gtttaccatg      180


<210>  10
<211>  183
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding an amino acid sequence comprising module 1 
       of the CBD of MMP-2 with stop codon

<400>  10
gtgaaatatg gtaatgccga tggcgaatat tgcaaatttc cgtttctgtt taacggcaaa       60

gagtataata gctgtaccga taccggtcgt agtgatggtt ttctgtggtg tagcaccacc      120

tataactttg agaaagatgg caaatatggc ttttgtccgc atgaagcact gtttaccatg      180

taa                                                                    183


<210>  11
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Glu Gly Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser 
1               5                   10                  15      


Tyr Asp Ser Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys 
            20                  25                  30          


Gly Thr Thr Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro 
        35                  40                  45              


Glu 
    


<210>  12
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence comprising module 2 of the CBD of MMP-2 with 
       additional residues

<400>  12

Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly Gln Pro Cys Lys Phe 
1               5                   10                  15      


Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser Cys Thr Thr Glu Gly 
            20                  25                  30          


Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr Glu Asp Tyr Asp Arg 
        35                  40                  45              


Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala 
    50                  55                  


<210>  13
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  13

Val Phe Thr Met Tyr Gly Asn Ala Glu Gly Gln Pro Cys Lys Phe Pro 
1               5                   10                  15      


Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser Cys Thr Thr Glu Gly Arg 
            20                  25                  30          


Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr Glu Asp Tyr Asp Arg Asp 
        35                  40                  45              


Lys Lys Tyr Gly Phe Cys Pro 
    50                  55  


<210>  14
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of a variant module corresponding to module 2
       of the CBD of MMP-2

<400>  14

Leu Phe Thr Met Gly Gly Asn Ala Glu Gly Gln Pro Cys Lys Phe Pro 
1               5                   10                  15      


Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser Cys Thr Thr Glu Gly Arg 
            20                  25                  30          


Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr Glu Asp Tyr Asp Arg Asp 
        35                  40                  45              


Lys Lys Tyr Gly Phe Cys Pro 
    50                  55  


<210>  15
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding a peptide comprising a variant module 
       corresponding to module 2 of the CBD of MMP-2

<400>  15
gcactgttta ccatgggtgg taatgcggaa ggtcagccgt gtaaatttcc ttttcgcttt       60

cagggcacca gctatgatag ttgtaccacc gaaggtcgta ccgatggtta tcgttggtgc      120

ggtacaaccg aagattatga tcgtgacaaa aaatacggtt tctgtccgga aaccgca         177


<210>  16
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding a peptide comprising a module corresponding
       to module 2 of the CBD of MMP-2 with stop codon

<400>  16
gcactgttta ccatgggtgg taatgcggaa ggtcagccgt gtaaatttcc ttttcgcttt       60

cagggcacca gctatgatag ttgtaccacc gaaggtcgta ccgatggtta tcgttggtgc      120

ggtacaaccg aagattatga tcgtgacaaa aaatacggtt tctgtccgga aaccgcataa      180


<210>  17
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  17

Ser Glu Gly Ala Pro Cys Val Phe Pro Phe Thr Phe Leu Gly Asn Lys 
1               5                   10                  15      


Tyr Glu Ser Cys Thr Ser Ala Gly Arg Ser Asp Gly Lys Met Trp Cys 
            20                  25                  30          


Ala Thr Thr Ala Asn Tyr Asp Asp Asp Arg Lys Trp Gly Phe Cys Pro 
        35                  40                  45              


Asp 
    


<210>  18
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of a peptide comprising module 3 of the CBD 
       of MMP-2 with additional residues

<400>  18

Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro 
1               5                   10                  15      


Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg 
            20                  25                  30          


Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp 
        35                  40                  45              


Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly 
    50                  55              


<210>  19
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of a variant module corresponding to module 3
       of the CBD of MMP-2

<400>  19

Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro 
1               5                   10                  15      


Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg 
            20                  25                  30          


Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp 
        35                  40                  45              


Arg Lys Trp Gly Phe Cys Pro 
    50                  55  


<210>  20
<211>  174
<212>  DNA
<213>  Homo sapiens

<400>  20
atgagcaccg ttggtggtaa tagtgaaggt gcaccgtgtg tttttccgtt tacctttctg       60

ggtaacaaat atgaaagctg taccagtgca ggtcgttcag atggtaaaat gtggtgcgca      120

accaccgcaa attatgatga tgatcgtaaa tggggttttt gcccagatca gggt            174


<210>  21
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding a peptide comprising a module corresponding to 
       module 3 of the CBD of MMP-2 with stop codon

<400>  21
atgagcaccg ttggtggtaa tagtgaaggt gcaccgtgtg tttttccgtt tacctttctg       60

ggtaacaaat atgaaagctg taccagtgca ggtcgttcag atggtaaaat gtggtgcgca      120

accaccgcaa attatgatga tgatcgtaaa tggggttttt gcccagatca gggttaa         177


<210>  22
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide 111 comprising three modules corresponding to 
       module 1 of the CBD of MMP-2

<400>  22

Glu Gly Gln Val Val Arg Val Lys Tyr Gly Asn Ala Asp Gly Glu Tyr 
1               5                   10                  15      


Cys Lys Phe Pro Phe Leu Phe Asn Gly Lys Glu Tyr Asn Ser Cys Thr 
            20                  25                  30          


Asp Thr Gly Arg Ser Asp Gly Phe Leu Trp Cys Ser Thr Thr Tyr Asn 
        35                  40                  45              


Phe Glu Lys Asp Gly Lys Tyr Gly Phe Cys Pro His Glu Ala Leu Phe 
    50                  55                  60                  


Val Met Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu 
65                  70                  75                  80  


Phe Asn Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp 
                85                  90                  95      


Gly Phe Arg Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys 
            100                 105                 110         


Tyr Gly Phe Cys Pro Glu Thr Ala Val Arg Val Lys Tyr Gly Asn Ala 
        115                 120                 125             


Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn Gly Lys Glu Tyr 
    130                 135                 140                 


Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe Leu Trp Cys Ser 
145                 150                 155                 160 


Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly Phe Cys Pro Asp 
                165                 170                 175     


Gln Gly Tyr Ser Leu 
            180     


<210>  23
<211>  543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding exemplary peptide 111

<400>  23
gaaggtcagg ttgttcgtgt gaaatatggt aatgcagatg gcgagtattg caaatttccg       60

tttctgttta acggcaaaga gtataatagc tgtaccgata ccggtcgtag tgatggtttt      120

ctgtggtgta gcaccaccta taactttgag aaagatggca aatatggctt ttgtccgcat      180

gaagcactgt ttgtgatgta tggcaatgcc gatggtgaat actgtaaatt cccatttctg      240

ttcaatggta aagaatacaa ctcatgcacc gatacaggcc gttcagatgg ctttcgttgg      300

tgttcaacca cctacaattt cgaaaaagac ggtaagtatg gtttctgtcc ggaaaccgca      360

gtgcgcgtta aatatggcaa cgcggacggg gaatattgta agtttccgtt cttattcaac      420

gggaaagaat ataacagttg cacagacacc ggtcgctcag atggtttttt atggtgctca      480

acaacgtata acttcgaaaa ggatgggaag tacggatttt gtccggatca gggttatagc      540

ctg                                                                    543


<210>  24
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding exemplary peptide 111 (with stop codon)

<400>  24
gaaggtcagg ttgttcgtgt gaaatatgtt aatgccgatg gcgagtattg caaatttccg       60

tttctgttta acggcaaaga gtataatagc tgtaccgata ccggtcgtag tgatggtttt      120

ctgtggtgta gcaccaccta taactttgag aaagatggca aatatggctt ttgtccgcat      180

gaagcactgt ttgtgatgta tgtgaatgcg gatggtgaat actgtaaatt cccctttctg      240

ttcaatggta aagaatacaa ctcatgcacc gatacaggcc gttcagatgg ctttcgttgg      300

tgttcaacca cctacaattt cgaaaaagac ggtaagtatg gtttctgtcc ggaaaccgca      360

gtgcgcgtta aatatgtgaa cgcagacggg gaatattgta agtttccgtt cttattcaac      420

gggaaagaat ataacagttg cacagacacc ggtcgctcag atggtttttt atggtgctca      480

acaacgtata acttcgaaaa ggatgggaag tacggatttt gtccggatca gggttatagc      540

ctgtaa                                                                 546


<210>  25
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide 222 comprising three modules corresponding to 
       module 2 of the CBD of MMP-2

<400>  25

Glu Gly Gln Val Val Phe Thr Met Tyr Gly Asn Ala Glu Gly Gln Pro 
1               5                   10                  15      


Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser Cys Thr 
            20                  25                  30          


Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr Glu Asp 
        35                  40                  45              


Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro His Glu Ala Leu Phe 
    50                  55                  60                  


Thr Met Gly Gly Asn Ala Glu Gly Gln Pro Cys Lys Phe Pro Phe Arg 
65                  70                  75                  80  


Phe Gln Gly Thr Ser Tyr Asp Ser Cys Thr Thr Glu Gly Arg Thr Asp 
                85                  90                  95      


Gly Tyr Arg Trp Cys Gly Thr Thr Glu Asp Tyr Asp Arg Asp Lys Lys 
            100                 105                 110         


Tyr Gly Phe Cys Pro Glu Thr Ala Leu Phe Thr Met Gly Gly Asn Ala 
        115                 120                 125             


Glu Gly Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr 
    130                 135                 140                 


Asp Ser Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly 
145                 150                 155                 160 


Thr Thr Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Asp 
                165                 170                 175     


Gln Gly Tyr Ser Leu 
            180     


<210>  26
<211>  543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding exemplary peptide 222

<400>  26
gaaggtcagg ttgtgtttac catgtatggt aatgccgaag gtcagccgtg taaatttccg       60

tttcgttttc agggcaccag ctatgatagt tgtaccaccg aaggtcgtac cgatggttat      120

cgttggtgtg gtacgaccga agattatgat cgtgataaaa agtatggctt ttgtccgcat      180

gaagccctgt ttacaatggg tggcaatgca gagggccagc cttgcaaatt cccttttcgc      240

ttccagggta catcttatga ttcatgcaca acggaaggtc gcacagatgg ctaccgctgg      300

tgcggcacca cagaggatta tgaccgcgac aaaaaatacg gtttttgtcc ggaaaccgca      360

ctgttcacca tgggtggtaa tgcggaagga caaccatgca agtttccatt ccgctttcag      420

ggaacctcat atgatagctg cacaacagag ggacgtacgg atggatacag atggtgcggt      480

acaaccgagg actacgatag agataagaaa tatggtttct gtcccgatca gggttatagc      540

ctg                                                                    543


<210>  27
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide 333 comprising three modules corresponding to 
       module 3 of the CBD of MMP-2

<400>  27

Glu Gly Gln Val Val Ser Thr Val Tyr Gly Asn Ser Glu Gly Ala Pro 
1               5                   10                  15      


Cys Val Phe Pro Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr 
            20                  25                  30          


Ser Ala Gly Arg Ser Asp Gly Phe Leu Trp Cys Ala Thr Thr Ala Asn 
        35                  40                  45              


Tyr Asp Asp Asp Arg Lys Trp Gly Phe Cys Pro His Glu Ala Leu Phe 
    50                  55                  60                  


Thr Met Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro Phe Thr 
65                  70                  75                  80  


Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg Ser Asp 
                85                  90                  95      


Gly Lys Arg Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp Arg Lys 
            100                 105                 110         


Trp Gly Phe Cys Pro Glu Thr Ala Met Ser Thr Val Gly Gly Asn Ser 
        115                 120                 125             


Glu Gly Ala Pro Cys Val Phe Pro Phe Thr Phe Leu Gly Asn Lys Tyr 
    130                 135                 140                 


Glu Ser Cys Thr Ser Ala Gly Arg Ser Asp Gly Lys Met Trp Cys Ala 
145                 150                 155                 160 


Thr Thr Ala Asn Tyr Asp Asp Asp Arg Lys Trp Gly Phe Cys Pro Asp 
                165                 170                 175     


Gln Gly Tyr Ser Leu 
            180     


<210>  28
<211>  543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding exemplary peptide 333

<400>  28
gaaggtcagg ttgttagcac cgtttatggt aatagcgaag gtgcaccgtg tgtttttccg       60

tttacctttc tgggtaacaa atatgaaagc tgtaccagcg caggtcgtag tgatggtttt      120

ctgtggtgtg caaccaccgc aaattatgat gatgatcgta aatggggttt ttgtccgcat      180

gaagcactgt ttaccatggg tggcaattct gaaggtgccc cttgcgtgtt tccttttaca      240

tttttaggca acaagtacga aagctgcacc tcagccggtc gttcagatgg taaacgttgg      300

tgcgccacca cagccaacta tgatgacgac agaaaatggg gcttctgtcc tgaaaccgca      360

atgagcaccg ttggtggcaa cagtgaaggc gctccatgcg ttttcccgtt cacattcctg      420

ggcaataaat acgaatcatg tacctctgca ggtcgctctg atggcaaaat gtggtgcgcg      480

acaacggcca attacgacga tgaccgcaag tggggctttt gcccagatca gggttatagc      540

ctg                                                                    543


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence 1

<400>  29

Glu Gly Gln Val 
1               


<210>  30
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence comprising a peptide comprising module 3 of 
       CBD of MMP-9 with additional residues

<400>  30

Ser Thr Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro 
1               5                   10                  15      


Phe Thr Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg 
            20                  25                  30          


Gly Asp Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp 
        35                  40                  45              


Lys Lys Trp Gly Phe Cys Pro Asp Gln Gly 
    50                  55              


<210>  31
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence comprising CBD of MMP-9 with additional 
       residues

<400>  31

Pro Thr Arg Phe Gly Asn Ala Asp Gly Ala Ala Cys His Phe Pro Phe 
1               5                   10                  15      


Ile Phe Glu Gly Arg Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser 
            20                  25                  30          


Asp Gly Leu Pro Trp Cys Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp 
        35                  40                  45              


Arg Phe Gly Phe Cys Pro Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn 
    50                  55                  60                  


Ala Asp Gly Lys Pro Cys Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser 
65                  70                  75                  80  


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys 
                85                  90                  95      


Ala Thr Thr Ala Asn Tyr Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro 
            100                 105                 110         


Thr Arg Ala Asp Ser Thr Val Met Gly Gly Asn Ser Ala Gly Glu Leu 
        115                 120                 125             


Cys Val Phe Pro Phe Thr Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr 
    130                 135                 140                 


Ser Glu Gly Arg Gly Asp Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn 
145                 150                 155                 160 


Phe Asp Ser Asp Lys Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser 
                165                 170                 175     


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence 4

<400>  32

Asp Gln Gly Tyr Ser Leu 
1               5       


<210>  33
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro 
            20                  25                  30          


Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr 
        35                  40                  45              


Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser 
    50                  55                  60                  


Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu 
65                  70                  75                  80  


Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr 
                85                  90                  95      


Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly 
            100                 105                 110         


Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr 
        115                 120                 125             


Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala 
    130                 135                 140                 


Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr 
145                 150                 155                 160 


Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly 
                165                 170                 175     


Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe 
            180                 185                 190         


Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu 
        195                 200                 205             


Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn 
    210                 215                 220                 


Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser 
225                 230                 235                 240 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys 
                245                 250                 255     


Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro 
            260                 265                 270         


Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys 
        275                 280                 285             


Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr 
    290                 295                 300                 


Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr 
305                 310                 315                 320 


Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr 
                325                 330                 335     


Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr 
            340                 345                 350         


Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp 
        355                 360                 365             


Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys 
    370                 375                 380                 


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
385                 390                 395                 400 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                405                 410                 415     


Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His 
            420                 425                 430         


Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu 
        435                 440                 445             


Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro 
    450                 455                 460                 


Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg 
465                 470                 475                 480 


Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro 
                485                 490                 495     


Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val 
            500                 505                 510         


Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly 
        515                 520                 525             


Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu 
    530                 535                 540                 


Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp 
545                 550                 555                 560 


Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Arg Leu Ser 
                565                 570                 575     


Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly 
            580                 585                 590         


Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala 
        595                 600                 605             


Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met 
    610                 615                 620                 


Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln 
625                 630                 635                 640 


Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly 
                645                 650                 655     


Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr 
            660                 665                 670         


Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu 
        675                 680                 685             


Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys 
    690                 695                 700                 


Pro Glu Asp 
705         


<210>  34
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser 
1               5                   10                  15      


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys 
            20                  25                  30          


Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro 
        35                  40                  45              


Ser 
    


<210>  35
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of a peptide comprising module 1 of CBD of 
       MMP-9 with additional residues

<400>  35

Thr Arg Phe Gly Asn Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile 
1               5                   10                  15      


Phe Glu Gly Arg Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp 
            20                  25                  30          


Gly Leu Pro Trp Cys Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg 
        35                  40                  45              


Phe Gly Phe Cys Pro Ser Glu Arg Leu Tyr Thr Gln 
    50                  55                  60  


<210>  36
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Asp Gly Lys Pro Cys Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser 
1               5                   10                  15      


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys 
            20                  25                  30          


Ala Thr Thr Ala Asn Tyr Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro 
        35                  40                  45              


Thr 
    


<210>  37
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of a peptide comprising module 2 of CBD of 
       MMP-9 with additional residues

<400>  37

Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys Gln Phe 
1               5                   10                  15      


Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr Asp Gly 
            20                  25                  30          


Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr Asp Arg 
        35                  40                  45              


Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala 
    50                  55                  


<210>  38
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  38

Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr Phe Leu Gly Lys Glu 
1               5                   10                  15      


Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp Gly Arg Leu Trp Cys 
            20                  25                  30          


Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys Trp Gly Phe Cys Pro 
        35                  40                  45              


Asp 
    


