                         SEQUENCE LISTING

<110>  Elixiron Immunotherapeutics Inc.
       Elixiron Immunotherapeutics (Hong Kong) Limited
       CHEN, Hung-Kai
       SHIH, Daw-Tsun
       KU, Cheng-Lun
       CHUNG, Pei-Han
 
<120>  METHODS FOR TREATMENT OF HBV INFECTION

<130>  09793-001WO1

<150>  62/650,195
<151>  2018-03-29

<150>  PCT/CN2018/085836
<151>  2018-05-07

<160>  188   

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  1
accatggact gsacctggag                                                   20


<210>  2
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  2
caccatggac acactttgct mcac                                              24


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  3
accatggaca tactttgttc cacg                                              24


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  4
atggagtttg ggctgagctg                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  5
atggaactgg ggctccgctg                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  6
atggagttgg ggctgtgctg                                                   20


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  7
catggagttt gggcttagct g                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  8
catggagttt tggctgagct g                                                 21


<210>  9
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  9
catgaaacac ctgtggttct tcct                                              24


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  10
aatgaagcac ctgtggttct tcct                                              24


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  11
acatgaaaca tctgtggttc ttcct                                             25


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  12
atggggtcaa ccgccatcct                                                   20


<210>  13
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  13
aatgtctgtc tccttcctca tcttcct                                           27


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  14
saggtgcagc tggtgsagtc                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  15
caggtccagc ttgtgcagtc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  16
caggttcagc tggtgcagtc                                                   20


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  17
caggtccagc tggtacagtc tg                                                22


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  18
caggtcacct garggagtct ggt                                               23


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
gaggtgcagc tgttggagtc t                                                 21


<210>  20
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  20
cagstgcagc tgcaggagt                                                    19


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  21
caggtgcagc tacarcagtg g                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  22
caggtacagc tgcagcagtc a                                                 21


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  23
caggtgcagc tggtgcaat                                                    19


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  24
ggtccccgct cagctcctgg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  25
agtcctcgct cagctcctgg                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  26
gctccctgct cagctcctgg                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  27
gctccttgct cagcttctgg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  28
cctgctactc tggctcccag                                                   20


<210>  29
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  29
atttctctgt tgctctggat ctctg                                             25


<210>  30
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  30
cttcctcctc ctttggatct ctg                                               23


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  31
tctgctgctc tgggttccag                                                   20


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  32
gacatccagw tgacccagtc tcc                                               23


<210>  33
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  33
gatattgtga tgacccagac tccactct                                          28


<210>  34
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  34
gatattgtga tgactcagtc tccactct                                          28


<210>  35
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  35
gaaattgtgt tgacrcagtc tccag                                             25


<210>  36
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  36
gaaatagtga tgacgcagtc tccag                                             25


<210>  37
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  37
gacatcgtga tgacccagtc tc                                                22


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  38
gaaacgacac tcacgcagtc tc                                                22


<210>  39
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  39
gaaattgtgc tgactcagtc tcca                                              24


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  40
ggtcctgggc ccagtctgtg                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  41
ggtcctgggc ycagtctgcc                                                   20


<210>  42
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  42
gctctgwggc ctcctatgag ct                                                22


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  43
gctctgtgac ctcctatgwg ctg                                               23


<210>  44
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  44
gttctgtggt ttcttctgag ctgact                                            26


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  45
ggtctctctc ccwgcytgtg c                                                 21


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  46
gttccctctc gcaggctgtg                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  47
gktccctctc ccagcctgtg                                                   20


<210>  48
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  48
gttcttgggc caattttatg ctg                                               23


<210>  49
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  49
ggtccaattc ycagrctgtg gtg                                               23


<210>  50
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  50
gagtggattc tcagactgtg gtga                                              24


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  51
tgtcagtggt ccaggcaggg                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  52
cagtctgtgy tgacgcagcc                                                   20


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  53
cagtctgtgc tgactcagcc a                                                 21


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  54
cagtctgccc tgactcagcc                                                   20


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  55
tcctatgagc tgacwcagcc a                                                 21


<210>  56
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  56
tcttctgagc tgactcagga cc                                                22


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  57
cagsctgtgc tgactcagcc                                                   20


<210>  58
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  58
cagcctgtgc tgactcaatc at                                                22


<210>  59
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  59
cagcttgtgc tgactcaatc g                                                 21


<210>  60
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  60
aattttatgc tgactcagcc ccac                                              24


<210>  61
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  61
cagrctgtgg tgacycagga gc                                                22


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  62
caggcagggc tgactcagcc                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  63
aggtgtgcac gccgctggtc                                                   20


<210>  64
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  64
ggttcgggga agtagtcctt gac                                               23


<210>  65
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  65
gtttctcgta gtctgctttg ctca                                              24


<210>  66
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  66
gtgctgtcct tgctgtcctg ct                                                22


<210>  67
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  67
ttggagggtk tggtggtctc cac                                               23


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  68
ttgacggggc tgcyatctgc                                                   20


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  69
cacrgctccc gggtagaagt c                                                 21


<210>  70
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  70
gttgctacgc gtgtcctgag csaggtgcag ctggtgsagt c                           41


<210>  71
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  71
gttgctacgc gtgtcctgag ccaggtccag cttgtgcagt c                           41


<210>  72
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  72
gttgctacgc gtgtcctgag ccaggttcag ctggtgcagt c                           41


<210>  73
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  73
gttgctacgc gtgtcctgag ccaggtccag ctggtacagt ctg                         43


<210>  74
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  74
gttgctacgc gtgtcctgag ccaggtcacc ttgarggagt ctg                         43


<210>  75
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  75
gttgctacgc gtgtcctgag cgaggtgcag ctgttggagt ct                          42


<210>  76
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  76
gttgctacgc gtgtcctgag ccagstgcag ctgcaggagt                             40


<210>  77
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  77
gttgctacgc gtgtcctgag ccaggtgcag ctacarcagt gg                          42


<210>  78
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  78
gttgctacgc gtgtcctgag ccaggtacag ctgcagcagt ca                          42


<210>  79
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  79
gttgctacgc gtgtcctgag ccaggtgcag ctggtgcaat                             40


<210>  80
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  80
gatgggccct tggtgctagc tgaggagacg gtgaccagg                              39


<210>  81
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  81
gatgggccct tggtgctagc tgaggagaca gtgaccaggg t                           41


<210>  82
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  82
gatgggccct tggtgctagc tgaagagacg gtgaccattg tc                          42


<210>  83
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  83
gatgggccct tggtgctagc tgaggagacg gtgaccgtg                              39


<210>  84
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  84
ggctcccagg tgcacgatgt gacatccagw tgacccagtc tcc                         43


<210>  85
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  85
ggctcccagg tgcacgatgt gatattgtga tgacccagac tccactct                    48


<210>  86
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  86
ggctcccagg tgcacgatgt gaaattgtgt tgacrcagtc tccag                       45


<210>  87
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  87
ggctcccagg tgcacgatgt gacatcgtga tgacccagtc tc                          42


<210>  88
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  88
ggctcccagg tgcacgatgt gaaacgacac tcacgcagtc tc                          42


<210>  89
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  89
ggctcccagg tgcacgatgt gaaattgtgc tgactcagtc tcca                        44


<210>  90
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  90
tgcagccacc gtacgtttga tttccacctt ggtccct                                37


<210>  91
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  91
tgcagccacc gtacgtttga tctccagctt ggtccct                                37


<210>  92
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  92
tgcagccacc gtacgtttga tatccacttt ggtccca                                37


<210>  93
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  93
tgcagccacc gtacgtttga tctccacctt ggtccct                                37


<210>  94
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  94
tgcagccacc gtacgtttaa tctccagtcg tgtccctt                               38


<210>  95
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  95
tccttgctta tgggtccgga gtggattctc agtctgtgyt gacgcagcc                   49


<210>  96
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  96
tccttgctta tgggtccgga gtggattctc agtctgtgct gactcagcca                  50


<210>  97
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  97
tccttgctta tgggtccgga gtggattctc agtctgccct gactcagcc                   49


<210>  98
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  98
tccttgctta tgggtccgga gtggattctt cctatgagct gacwcagcca                  50


<210>  99
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  99
tccttgctta tgggtccgga gtggattctt cttctgagct gactcaggac                  50


<210>  100
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  100
tccttgctta tgggtccgga gtggattctc agsctgtgct gactcagcc                   49


<210>  101
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  101
tccttgctta tgggtccgga gtggattctc agyctgtgct gactcaatc                   49


<210>  102
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  102
tccttgctta tgggtccgga gtggattcta attttatgct gactcagccc                  50


<210>  103
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  103
tccttgctta tgggtccgga gtggattctc agrctgtggt gacycaggag                  50


<210>  104
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  104
tccttgctta tgggtccgga gtggattctc aggcagggct gactcagcc                   49


<210>  105
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  105
ggccttgggc tgacctagga cggtgacctt ggtcc                                  35


<210>  106
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  106
ggccttgggc tgacctagga cggtcagctt ggtcc                                  35


<210>  107
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  107
ggccttgggc tgacctagga cggtcacctt ggtgc                                  35


<210>  108
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  108
ggccttgggc tgacctagga cggtcagctg ggtgc                                  35


<210>  109
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Asp 
1               5                   10                  15      


Ser Leu Thr Val Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Arg Thr Lys Tyr Met Phe Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Arg Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Asn Asn Ser Val Tyr 
65                  70                  75                  80  


Leu His Met Ser Ser Leu Arg Gly Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Asp His Ser Asp Ser Asn Ser Ala Ala Asp Leu Leu 
            100                 105                 110         


His Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  110
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  110

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Arg Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Met Thr Ser Arg Thr Asn His Lys Tyr Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Leu Ile Ser Arg Asp Asn Asp Arg Asp Ser Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Gly Val Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Tyr Asp Thr Ser Gly Ser Asp Ser Gly Val Asp Phe Gln 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  111
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  111

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Pro Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Asp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Arg Asp Ser Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Ser Gly Arg Asn Ile Ile Ser Pro Gly Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  112
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Val Ala Ser Gly Phe Asn Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Asn Ser Gly Ser His Thr Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Pro Ser Ile Met Arg Gly Thr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  113
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  113

Asn Phe Met Leu Thr Gln Pro Leu Ser Val Ser Gly Tyr Pro Gly Lys 
1               5                   10                  15      


Thr Ile Val Ile Ser Cys Val Arg Ser Ser Gly Ser Val Ala Ser His 
            20                  25                  30          


Tyr Val Gln Trp Phe Gln Gln Arg Pro Gly Ser Ala Pro Ala Met Val 
        35                  40                  45              


Ile Tyr Glu Asp Ser His Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Val Asp Ala Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Phe Cys Gln Ser Tyr Tyr Gly 
                85                  90                  95      


Asn Asn Gln Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  114
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  114

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Ile Thr Ile Ser Cys Thr Arg Gly Arg Gly Tyr Ile Ala Ser Tyr 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Gly Val Pro Lys Ile Val 
        35                  40                  45              


Val Phe Glu Asp Thr Gln Arg Pro Ser Gly Val Pro Asp Arg Ile Ser 
    50                  55                  60                  


Gly Ser Ile Asp Thr Ser Thr Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asp 
                85                  90                  95      


Ala Asn His Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  115
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  115

Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Thr Cys Thr Leu Asn Ser Asp Tyr Gly Asp Tyr Lys 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Arg Pro Gly Lys Gly Pro Arg Phe Val Met 
        35                  40                  45              


Arg Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Asp Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Phe Leu Thr Ile 
65                  70                  75                  80  


Lys Asn Ile Gln Glu Glu Asp Glu Ser Asp Tyr Tyr Cys Gly Ala Asp 
                85                  90                  95      


His Gly Ser Ala Asn Asn Phe Ile Trp Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu 
        115     


<210>  116
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  116

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn 
            20                  25                  30          


Pro Val Ser Trp Tyr Gln Gln Phe Pro Gly Met Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Phe Asn Asn Gln Arg Pro Ser Gly Val Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Pro Ala Ser Leu Ala Ile Gly Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asn Tyr Tyr Cys Ala Ser Trp Asp Asp Thr Leu 
                85                  90                  95      


Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  117
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  117
gctcccaggt gcacgatgtg                                                   20


<210>  118
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  118
gcttatgggt ccggagtgga ttct                                              24


<210>  119
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  119
gatgggccct tggtgctagc                                                   20


<210>  120
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  120

Gly Phe Thr Phe Ser Asn Tyr Phe 
1               5               


<210>  121
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  121

Ile Ser Gly Arg Thr Lys Tyr Met 
1               5               


<210>  122
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  122

Val Arg Gly Tyr Asp His Ser Asp Ser Asn Ser Ala Ala Asp Leu Leu 
1               5                   10                  15      


His 
    


<210>  123
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  123

Gly Phe Pro Phe Ser Arg Tyr Ser 
1               5               


<210>  124
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Thr Ser Arg Thr Asn His Lys 
1               5               


<210>  125
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  125

Ala Arg Gly Tyr Asp Thr Ser Gly Ser Asp Ser Gly Val Asp Phe Gln 
1               5                   10                  15      


Tyr 
    


<210>  126
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  126

Gly Phe Thr Phe Ser Ile Tyr Ser 
1               5               


<210>  127
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  127

Ile Ser Gly Ser Gly Asp Asn Thr 
1               5               


<210>  128
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  128

Ala Lys Ser Gly Arg Asn Ile Ile Ser Pro Gly Phe Asp Ser 
1               5                   10                  


<210>  129
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  129

Gly Phe Asn Phe Ser Asp Tyr Tyr 
1               5               


<210>  130
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  130

Ile Ser Asn Ser Gly Ser His Thr 
1               5               


<210>  131
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  131

Ala Arg Asp Pro Ser Ile Met Arg Gly Thr Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  132
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  132

Ser Gly Ser Val Ala Ser His Tyr 
1               5               


<210>  133
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  133

Glu Asp Ser 
1           


<210>  134
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  134

Gln Ser Tyr Tyr Gly Asn Asn Gln Val Leu 
1               5                   10  


<210>  135
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  135

Arg Gly Tyr Ile Ala Ser Tyr Tyr 
1               5               


<210>  136
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  136

Glu Asp Thr 
1           


<210>  137
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  137

Gln Ser Tyr Asp Asp Ala Asn His Val Ile 
1               5                   10  


<210>  138
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  138

Ser Asp Tyr Gly Asp Tyr Lys 
1               5           


<210>  139
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  139

Val Gly Thr Gly Gly Ile Val Gly 
1               5               


<210>  140
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  140

Gly Ala Asp His Gly Ser Ala Asn Asn Phe Ile Trp Val 
1               5                   10              


<210>  141
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  141

Ser Ser Asn Ile Gly Thr Asn Pro 
1               5               


<210>  142
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  142

Phe Asn Asn 
1           


<210>  143
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  143

Ala Ser Trp Asp Asp Thr Leu Asn Gly Leu Val 
1               5                   10      


<210>  144
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  144

Gly Phe Thr Phe Ser Asn Tyr Phe Ile His 
1               5                   10  


<210>  145
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  145

Thr Ile Ser Gly Arg Thr Lys Tyr Met Phe Tyr Ser Asp Ser Leu Arg 
1               5                   10                  15      


Gly 
    


<210>  146
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  146

Gly Tyr Asp His Ser Asp Ser Asn Ser Ala Ala Asp Leu Leu His 
1               5                   10                  15  


<210>  147
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  147

Gly Phe Pro Phe Ser Arg Tyr Ser Met His 
1               5                   10  


<210>  148
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  148

Ser Met Thr Ser Arg Thr Asn His Lys Tyr Tyr Ala Asp Ser Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  149
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  149

Gly Tyr Asp Thr Ser Gly Ser Asp Ser Gly Val Asp Phe Gln Tyr 
1               5                   10                  15  


<210>  150
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  150

Gly Phe Thr Phe Ser Ile Tyr Ser Met Asn 
1               5                   10  


<210>  151
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  151

Ser Ile Ser Gly Ser Gly Asp Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  152
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  152

Ser Gly Arg Asn Ile Ser Pro Gly Phe Asp Ser 
1               5                   10      


<210>  153
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  153

Gly Phe Asn Phe Ser Asp Tyr Tyr Met Thr 
1               5                   10  


<210>  154
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  154

Tyr Ile Ser Asn Ser Gly Ser His Thr Tyr Tyr Ala Asp Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  155
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  155

Asp Pro Ser Ile Met Arg Gly Thr Tyr Tyr Met Asp Val 
1               5                   10              


<210>  156
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  156

Val Arg Ser Ser Gly Ser Val Ala Ser His Tyr Val Gln 
1               5                   10              


<210>  157
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  157

Glu Asp Ser His Arg Pro Ser 
1               5           


<210>  158
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  158

Thr Arg Gly Arg Gly Tyr Ile Ala Ser Tyr Tyr Val Gln 
1               5                   10              


<210>  159
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  159

Glu Asp Thr Gln Arg Pro Ser 
1               5           


<210>  160
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  160

Thr Leu Asn Ser Asp Tyr Gly Asp Tyr Lys Val Asp 
1               5                   10          


<210>  161
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  161

Val Gly Thr Gly Gly Ile Val 
1               5           


<210>  162
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  162

Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn Pro Val Ser 
1               5                   10              


<210>  163
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  163

Phe Asn Asn Gln Arg Pro Ser 
1               5           


<210>  164
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant variant antibody sequence

<400>  164

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Asp 
1               5                   10                  15      


Ser Leu Thr Val Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Arg Thr Lys Tyr Met Phe Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Arg Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Ala Asn Ser Val Tyr 
65                  70                  75                  80  


Leu His Met Ser Ser Leu Arg Gly Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Asp His Ser Asp Ser Asn Ser Ala Ala Asp Leu Leu 
            100                 105                 110         


His Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  165
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant variant antibody sequence

<400>  165

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Asp 
1               5                   10                  15      


Ser Leu Thr Val Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Arg Thr Lys Tyr Met Phe Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Arg Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Gln Asn Ser Val Tyr 
65                  70                  75                  80  


Leu His Met Ser Ser Leu Arg Gly Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Asp His Ser Asp Ser Asn Ser Ala Ala Asp Leu Leu 
            100                 105                 110         


His Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  166
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  166

Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe Asn 
1               5                   10                  15      


Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly Ile 
            20                  25                  30          


Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser Gln 
        35                  40                  45              


Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp Gln 
    50                  55                  60                  


Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val Lys 
65                  70                  75                  80  


Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu Thr 
                85                  90                  95      


Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His Glu 
            100                 105                 110         


Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly Lys 
        115                 120                 125             


Arg Lys Arg Ser Gln Met Leu Phe Arg Gly Arg Arg Ala Ser Gln 
    130                 135                 140             


<210>  167
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  167

Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met 
1               5                   10                  15      


Gln Ser Gln Ile Val Ser Phe 
            20              


<210>  168
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  168

Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe 
1               5                   10                  15  


<210>  169
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  169
cgtttctaga gacaacgccc agaattcggt atatctccac a                           41


<210>  170
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER

<400>  170
cgtttctaga gacaacgccg ccaattcggt atatctccac                             40


<210>  171
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  171

Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser Gln 
1               5                   10              


<210>  172
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  172

Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe 
1               5                   10      


<210>  173
<211>  373
<212>  DNA
<213>  Homo sapiens

<400>  173
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc cgggggactc tctgacagtc       60

tcctgtgtcg cctctggatt cactttcagc aactatttca tccactgggt ccgacaggct      120

ccagggaagg gactggagtg ggtcgcaacg atcagtggcc gtacgaaata tatgttctac      180

tcagactcat tgaggggccg attcaccgtt tctagagaca acgccaacaa ttcggtatat      240

ctccacatga gcagcctgag aggcgaagac acggctctct attactgtgt gagaggctat      300

gatcatagtg attccaactc ggcagcagac ctcctgcatt ggggccgggg caccctggtc      360

accgtctcct cag                                                         373


<210>  174
<211>  334
<212>  DNA
<213>  Homo sapiens

<400>  174
aattttatgc tgactcagcc cctctctgtg tcgggctatc cgggaaagac gatagtcatc       60

tcctgtgtcc ggagcagtgg cagcgtggcc agccactatg tgcagtggtt ccaacagcgc      120

ccgggcagtg cccccgccat ggtgatttat gaagatagcc acagaccttc tgggattcct      180

gatcgattct ctggctccgt cgacgcctcc tccaactctg cctccctcac catctctgga      240

ctgaagactg aggacgaggc tgactacttc tgtcaatctt attatggcaa caatcaggtt      300

ctcttcggcg gcgggaccaa gctgaccgtc ctag                                  334


<210>  175
<211>  373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ANTIBODY

<400>  175
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc cgggggactc tctgacagtc       60

tcctgtgtcg cctctggatt cactttcagc aactatttca tccactgggt ccgacaggct      120

ccagggaagg gactggagtg ggtcgcaacg atcagtggcc gtacgaaata tatgttctac      180

tcagactcat tgaggggccg attcaccgtt tctagagaca acgcccagaa ttcggtatat      240

ctccacatga gcagcctgag aggcgaagac acggctctct attactgtgt gagaggctat      300

gatcatagtg attccaactc ggcagcagac ctcctgcatt ggggccgggg caccctggtc      360

accgtctcct cag                                                         373


<210>  176
<211>  373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ANTIBODY

<400>  176
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc cgggggactc tctgacagtc       60

tcctgtgtcg cctctggatt cactttcagc aactatttca tccactgggt ccgacaggct      120

ccagggaagg gactggagtg ggtcgcaacg atcagtggcc gtacgaaata tatgttctac      180

tcagactcat tgaggggccg attcaccgtt tctagagaca acgccgccaa ttcggtatat      240

ctccacatga gcagcctgag aggcgaagac acggctctct attactgtgt gagaggctat      300

gatcatagtg attccaactc ggcagcagac ctcctgcatt ggggccgggg caccctggtc      360

accgtctcct cag                                                         373


<210>  177
<211>  373
<212>  DNA
<213>  Homo sapiens

<400>  177
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggctt ccccttcagt cgctattcaa tgcactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcg atgacgtctc ggactaacca caaatactac      180

gcagactcac tgaagggccg attcctcatc tctcgagaca acgacaggga ctcactgtac      240

ctggaaatga acagcctggg agtcgaggac acggcgatat atttctgtgc aagaggctat      300

gatactagtg gttccgactc gggagtagac ttccaatact ggggccaggg caccctggtc      360

accgtctcct cag                                                         373


<210>  178
<211>  334
<212>  DNA
<213>  Homo sapiens

<400>  178
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac gataaccatc       60

tcctgcaccc gcggcagagg atacattgcc agctactatg tccagtggta ccaacagcgc      120

ccgggcggtg tccccaaaat tgtggtcttt gaggatactc agagaccctc tggggtccct      180

gatcgaatct ctggctccat cgacacctcc accaactctg cctccctcac catctctgga      240

ctgcagactg aagacgaggc tgactactac tgtcagtctt atgatgatgc caatcatgtg      300

atcttcggcg gagggaccaa gctgaccgtc ctag                                  334


<210>  179
<211>  364
<212>  DNA
<213>  Homo sapiens

<400>  179
gaggtgcagc tgttggagtc tgggggaggc ctggtacagc cgggggggcc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc atctacagta tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attagtggga gtggcgataa tacatactat      180

gcagactccg tgaagggccg gttcaccatc accagagaca gttccaagaa cacactgtat      240

ctgcaaatga acaccctcag agccgaggac acggccgtat atttttgtgc gaaatctgga      300

agaaatatta tatcccctgg atttgactcc tggggccagg gaaccctggt caccgtctcc      360

tcag                                                                   364


<210>  180
<211>  349
<212>  DNA
<213>  Homo sapiens

<400>  180
cagcctgtgc tgactcagcc accttctgca tcagcctccc tgggagcctc ggtcacactc       60

acgtgcaccc tgaacagcga ctatggtgat tataaagtgg actggtacca gcagagacca      120

gggaagggcc cccgatttgt gatgcgagtg ggcactggtg ggattgtggg atccaagggg      180

gacggcatcc ctgatcgctt ctcagtcttg gggtcaggcc tgaatcggtt cctgaccatt      240

aagaacatcc aggaagagga tgagagtgac tactactgtg gggcagacca tggcagtgcg      300

aacaacttca tttgggtgtt cggcggaggg accaagctga ccgtcctag                  349


<210>  181
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  181
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagagtc cctgagactc       60

gcctgtgtag cctctggctt caacttcagt gactactaca tgacgtggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatat attagtaata gtggtagtca cacatactac      180

gcagacgctg tgaagggccg cttcaccgtc tccagggaca atgccaagaa ctcactgtat      240

ctgcaaatga ccagcctgag aggcgaggac acggccatat atttctgtgc gagagatcct      300

tctatcatgc ggggaaccta ctacatggac gtctggggca aagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210>  182
<211>  331
<212>  DNA
<213>  Homo sapiens

<400>  182
cagtctgtgc tgactcagcc accctcagcg tctggaaccc ccggccagag ggtcaccatc       60

tcttgttccg gaagcagctc caacatcgga actaaccctg tcagttggta ccagcagttc      120

cccggaatgg cccccaagct cctcatctat tttaacaatc agcggccctc aggggtccct      180

gaacgattct ctggctccaa gtctggcacc ccagcctccc tggccatcgg tggactccag      240

tctgaggatg aggctaacta ttattgtgca tcctgggatg acaccctgaa tggtctggtg      300

ttcggcggag ggaccaagct gaccgtccta g                                     331


<210>  183
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  183

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Asp 
1               5                   10                  15      


Ser Leu Thr Val Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Arg Thr Lys Tyr Met Phe Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Arg Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Asn Asn Ser Val Tyr 
65                  70                  75                  80  


Leu His Met Ser Ser Leu Arg Gly Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Asp His Ser Asp Ser Asn Ser Ala Ala Asp Leu Leu 
            100                 105                 110         


His Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  184
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  184

Asn Phe Met Leu Thr Gln Pro Leu Ser Val Ser Gly Tyr Pro Gly Lys 
1               5                   10                  15      


Thr Ile Val Ile Ser Cys Val Arg Ser Ser Gly Ser Val Ala Ser His 
            20                  25                  30          


Tyr Val Gln Trp Phe Gln Gln Arg Pro Gly Ser Ala Pro Ala Met Val 
        35                  40                  45              


Ile Tyr Glu Asp Ser His Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Val Asp Ala Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Phe Cys Gln Ser Tyr Tyr Gly 
                85                  90                  95      


Asn Asn Gln Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  185
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  185

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Arg Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Met Thr Ser Arg Thr Asn His Lys Tyr Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Leu Ile Ser Arg Asp Asn Asp Arg Asp Ser Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Gly Val Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Tyr Asp Thr Ser Gly Ser Asp Ser Gly Val Asp Phe Gln 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  186
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  186

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Ile Thr Ile Ser Cys Thr Arg Gly Arg Gly Tyr Ile Ala Ser Tyr 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Gly Val Pro Lys Ile Val 
        35                  40                  45              


Val Phe Glu Asp Thr Gln Arg Pro Ser Gly Val Pro Asp Arg Ile Ser 
    50                  55                  60                  


Gly Ser Ile Asp Thr Ser Thr Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asp 
                85                  90                  95      


Ala Asn His Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  187
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody variant

<400>  187

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Asp 
1               5                   10                  15      


Ser Leu Thr Val Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Arg Thr Lys Tyr Met Phe Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Arg Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Ala Asn Ser Val Tyr 
65                  70                  75                  80  


Leu His Met Ser Ser Leu Arg Gly Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Asp His Ser Asp Ser Asn Ser Ala Ala Asp Leu Leu 
            100                 105                 110         


His Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  188
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody variant

<400>  188

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Asp 
1               5                   10                  15      


Ser Leu Thr Val Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Arg Thr Lys Tyr Met Phe Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Arg Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Gln Asn Ser Val Tyr 
65                  70                  75                  80  


Leu His Met Ser Ser Leu Arg Gly Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Asp His Ser Asp Ser Asn Ser Ala Ala Asp Leu Leu 
            100                 105                 110         


His Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


