                               SEQUENCE LISTING

<110> EUREKA THERAPEUTICS, INC.
 
<120> CONSTRUCTS TARGETING CD22 AND USES THEREOF

<130> 101496-1131784-000310WO

<140> PCT/US2019/025032
<141> 2019-03-29

<150> 62/650,955
<151> 2018-03-30

<160> 244   

<170> PatentIn version 3.5

<210> 1
<211> 1066
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
        35                  40                  45              


Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr 
65                  70                  75                  80  


Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile 
                85                  90                  95      


Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr 
        115                 120                 125             


Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
145                 150                 155                 160 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                165                 170                 175     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            180                 185                 190         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        195                 200                 205             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    210                 215                 220                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
225                 230                 235                 240 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                245                 250                 255     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            260                 265                 270         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        275                 280                 285             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    290                 295                 300                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
305                 310                 315                 320 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                325                 330                 335     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            340                 345                 350         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        355                 360                 365             


Pro Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser 
    370                 375                 380                 


Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
385                 390                 395                 400 


Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                405                 410                 415     


Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu 
            420                 425                 430         


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
        435                 440                 445             


Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp 
    450                 455                 460                 


Ser Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
465                 470                 475                 480 


Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser 
                485                 490                 495     


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
            500                 505                 510         


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser 
        515                 520                 525             


Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn 
    530                 535                 540                 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
545                 550                 555                 560 


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
                565                 570                 575     


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp 
            580                 585                 590         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        595                 600                 605             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    610                 615                 620                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
625                 630                 635                 640 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser 
                645                 650                 655     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            660                 665                 670         


Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu 
        675                 680                 685             


Leu Trp Val Pro Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro 
    690                 695                 700                 


Ser Val Ser Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly 
705                 710                 715                 720 


Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly 
                725                 730                 735     


Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly 
            740                 745                 750         


Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu 
        755                 760                 765             


Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln 
    770                 775                 780                 


Val Trp Asp Ser Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys 
785                 790                 795                 800 


Leu Thr Val Leu Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                805                 810                 815     


Ser Gly Gly Gly Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln 
            820                 825                 830         


Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys 
        835                 840                 845             


Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg 
    850                 855                 860                 


Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly 
865                 870                 875                 880 


Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile 
                885                 890                 895     


Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu 
            900                 905                 910         


Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly 
        915                 920                 925             


Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp 
    930                 935                 940                 


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Ile 
945                 950                 955                 960 


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
                965                 970                 975     


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
            980                 985                 990         


Pro Gly Pro Ser Lys Pro Phe Trp  Val Leu Val Val Val  Gly Gly Val 
        995                 1000                 1005             


Leu Ala  Cys Tyr Ser Leu Leu  Val Thr Val Ala Phe  Ile Ile Phe 
    1010                 1015                 1020             


Trp Val  Arg Ser Lys Arg Ser  Arg Leu Leu His Ser  Asp Tyr Met 
    1025                 1030                 1035             


Asn Met  Thr Pro Arg Arg Pro  Gly Pro Thr Arg Lys  His Tyr Gln 
    1040                 1045                 1050             


Pro Tyr  Ala Pro Pro Arg Asp  Phe Ala Ala Tyr Arg  Ser 
    1055                 1060                 1065     


<210> 2
<211> 642
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr 
                245                 250                 255     


Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile 
            260                 265                 270         


Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu 
        275                 280                 285             


Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala 
    290                 295                 300                 


Lys Leu Phe Phe Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
            340                 345                 350         


Leu Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser 
        355                 360                 365             


Pro Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    370                 375                 380                 


Gln Ala Ser His Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
385                 390                 395                 400 


Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln 
                405                 410                 415     


Thr Gly Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe 
            420                 425                 430         


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
        435                 440                 445             


Cys Gln Gln Tyr Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg 
    450                 455                 460                 


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
465                 470                 475                 480 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                485                 490                 495     


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            500                 505                 510         


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        515                 520                 525             


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
    530                 535                 540                 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
545                 550                 555                 560 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro 
                565                 570                 575     


Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys 
            580                 585                 590         


Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr 
        595                 600                 605             


Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile 
    610                 615                 620                 


Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu 
625                 630                 635                 640 


Lys Ser 
        


<210> 3
<211> 1054
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr 
                245                 250                 255     


Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile 
            260                 265                 270         


Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu 
        275                 280                 285             


Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala 
    290                 295                 300                 


Lys Leu Phe Phe Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
            340                 345                 350         


Leu Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser 
        355                 360                 365             


Pro Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    370                 375                 380                 


Gln Ala Ser His Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
385                 390                 395                 400 


Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln 
                405                 410                 415     


Thr Gly Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe 
            420                 425                 430         


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
        435                 440                 445             


Cys Gln Gln Tyr Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg 
    450                 455                 460                 


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
465                 470                 475                 480 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                485                 490                 495     


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            500                 505                 510         


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        515                 520                 525             


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
    530                 535                 540                 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
545                 550                 555                 560 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro 
                565                 570                 575     


Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys 
            580                 585                 590         


Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr 
        595                 600                 605             


Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile 
    610                 615                 620                 


Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu 
625                 630                 635                 640 


Lys Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
                645                 650                 655     


Asp Val Glu Glu Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu 
            660                 665                 670         


Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr Gly Leu Pro Val Leu 
        675                 680                 685             


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Arg Ile 
    690                 695                 700                 


Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln 
705                 710                 715                 720 


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp 
                725                 730                 735     


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
            740                 745                 750         


Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp 
        755                 760                 765             


Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Tyr Val Val Phe Gly 
    770                 775                 780                 


Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Arg Gly Gly Gly Gly Ser 
785                 790                 795                 800 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Met Ala Glu Val 
                805                 810                 815     


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu 
            820                 825                 830         


Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile 
        835                 840                 845             


Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile 
    850                 855                 860                 


Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly 
865                 870                 875                 880 


Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
                885                 890                 895     


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            900                 905                 910         


Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn Trp Trp 
        915                 920                 925             


Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    930                 935                 940                 


Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
945                 950                 955                 960 


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
                965                 970                 975     


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
            980                 985                 990         


Val Gly Gly Val Leu Ala Cys Tyr  Ser Leu Leu Val Thr  Val Ala Phe 
        995                 1000                 1005             


Ile Ile  Phe Trp Val Arg Ser  Lys Arg Ser Arg Leu  Leu His Ser 
    1010                 1015                 1020             


Asp Tyr  Met Asn Met Thr Pro  Arg Arg Pro Gly Pro  Thr Arg Lys 
    1025                 1030                 1035             


His Tyr  Gln Pro Tyr Ala Pro  Pro Arg Asp Phe Ala  Ala Tyr Arg 
    1040                 1045                 1050             


Ser 
    


<210> 4
<211> 894
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
385                 390                 395                 400 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                405                 410                 415     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            420                 425                 430         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        435                 440                 445             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    450                 455                 460                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
465                 470                 475                 480 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                485                 490                 495     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            500                 505                 510         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        515                 520                 525             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    530                 535                 540                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
545                 550                 555                 560 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                565                 570                 575     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            580                 585                 590         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        595                 600                 605             


Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    610                 615                 620                 


Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His 
625                 630                 635                 640 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                645                 650                 655     


Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro 
            660                 665                 670         


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        675                 680                 685             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    690                 695                 700                 


Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
705                 710                 715                 720 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                725                 730                 735     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            740                 745                 750         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        755                 760                 765             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    770                 775                 780                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
785                 790                 795                 800 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                805                 810                 815     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Ile Lys Thr Asp 
            820                 825                 830         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        835                 840                 845             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    850                 855                 860                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
865                 870                 875                 880 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                885                 890                 


<210> 5
<211> 1316
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
385                 390                 395                 400 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                405                 410                 415     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            420                 425                 430         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        435                 440                 445             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    450                 455                 460                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
465                 470                 475                 480 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                485                 490                 495     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            500                 505                 510         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        515                 520                 525             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    530                 535                 540                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
545                 550                 555                 560 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                565                 570                 575     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            580                 585                 590         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        595                 600                 605             


Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    610                 615                 620                 


Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His 
625                 630                 635                 640 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                645                 650                 655     


Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro 
            660                 665                 670         


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        675                 680                 685             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    690                 695                 700                 


Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
705                 710                 715                 720 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                725                 730                 735     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            740                 745                 750         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        755                 760                 765             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    770                 775                 780                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
785                 790                 795                 800 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                805                 810                 815     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Ile Lys Thr Asp 
            820                 825                 830         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        835                 840                 845             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    850                 855                 860                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
865                 870                 875                 880 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser 
                885                 890                 895     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            900                 905                 910         


Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu 
        915                 920                 925             


Leu Trp Val Pro Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro 
    930                 935                 940                 


Ser Val Ser Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly 
945                 950                 955                 960 


Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly 
                965                 970                 975     


Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly 
            980                 985                 990         


Ile Pro Glu Arg Phe Ser Gly Ser  Asn Ser Gly Asn Thr  Ala Thr Leu 
        995                 1000                 1005             


Thr Ile  Ser Arg Val Glu Ala  Gly Asp Glu Ala Asp  Tyr Tyr Cys 
    1010                 1015                 1020             


Gln Val  Trp Asp Ser Ser Ser  Asp Tyr Val Val Phe  Gly Gly Gly 
    1025                 1030                 1035             


Thr Lys  Leu Thr Val Leu Gly  Ser Arg Gly Gly Gly  Gly Ser Gly 
    1040                 1045                 1050             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Leu Glu Met  Ala Glu Val 
    1055                 1060                 1065             


Gln Leu  Val Gln Ser Gly Ala  Glu Val Lys Lys Pro  Gly Glu Ser 
    1070                 1075                 1080             


Leu Lys  Ile Ser Cys Lys Gly  Ser Gly Tyr Ser Phe  Thr Ser Tyr 
    1085                 1090                 1095             


Trp Ile  Gly Trp Val Arg Gln  Met Pro Gly Lys Gly  Leu Glu Trp 
    1100                 1105                 1110             


Met Gly  Ile Ile Tyr Pro Gly  Asp Ser Asp Thr Arg  Tyr Ser Pro 
    1115                 1120                 1125             


Ser Phe  Gln Gly Gln Val Thr  Ile Ser Ala Asp Lys  Ser Ile Ser 
    1130                 1135                 1140             


Thr Ala  Tyr Leu Gln Trp Ser  Ser Leu Lys Ala Ser  Asp Thr Ala 
    1145                 1150                 1155             


Met Tyr  Tyr Cys Ala Arg Gln  Val Trp Gly Trp Gln  Gly Gly Met 
    1160                 1165                 1170             


Tyr Pro  Arg Ser Asn Trp Trp  Tyr Asn Leu Asp Ser  Trp Gly Gln 
    1175                 1180                 1185             


Gly Thr  Leu Val Thr Val Ser  Ser Glu Gln Lys Leu  Ile Ser Glu 
    1190                 1195                 1200             


Glu Asp  Leu Ala Ala Ala Ile  Glu Val Met Tyr Pro  Pro Pro Tyr 
    1205                 1210                 1215             


Leu Asp  Asn Glu Lys Ser Asn  Gly Thr Ile Ile His  Val Lys Gly 
    1220                 1225                 1230             


Lys His  Leu Cys Pro Ser Pro  Leu Phe Pro Gly Pro  Ser Lys Pro 
    1235                 1240                 1245             


Phe Trp  Val Leu Val Val Val  Gly Gly Val Leu Ala  Cys Tyr Ser 
    1250                 1255                 1260             


Leu Leu  Val Thr Val Ala Phe  Ile Ile Phe Trp Val  Arg Ser Lys 
    1265                 1270                 1275             


Arg Ser  Arg Leu Leu His Ser  Asp Tyr Met Asn Met  Thr Pro Arg 
    1280                 1285                 1290             


Arg Pro  Gly Pro Thr Arg Lys  His Tyr Gln Pro Tyr  Ala Pro Pro 
    1295                 1300                 1305             


Arg Asp  Phe Ala Ala Tyr Arg  Ser 
    1310                 1315     


<210> 6
<211> 1303
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
385                 390                 395                 400 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                405                 410                 415     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            420                 425                 430         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        435                 440                 445             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    450                 455                 460                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
465                 470                 475                 480 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                485                 490                 495     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            500                 505                 510         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        515                 520                 525             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    530                 535                 540                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
545                 550                 555                 560 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                565                 570                 575     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            580                 585                 590         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        595                 600                 605             


Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    610                 615                 620                 


Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His 
625                 630                 635                 640 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                645                 650                 655     


Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro 
            660                 665                 670         


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        675                 680                 685             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    690                 695                 700                 


Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
705                 710                 715                 720 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                725                 730                 735     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            740                 745                 750         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        755                 760                 765             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    770                 775                 780                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
785                 790                 795                 800 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                805                 810                 815     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Ile Lys Thr Asp 
            820                 825                 830         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        835                 840                 845             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    850                 855                 860                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
865                 870                 875                 880 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser 
                885                 890                 895     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            900                 905                 910         


Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu 
        915                 920                 925             


Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro 
    930                 935                 940                 


Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
945                 950                 955                 960 


Ala Ser His Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                965                 970                 975     


Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr 
            980                 985                 990         


Gly Val Pro Ser Arg Phe Ser Gly  Arg Gly Ser Gly Thr  Asp Phe Thr 
        995                 1000                 1005             


Leu Thr  Ile Ser Ser Leu Gln  Pro Glu Asp Ile Ala  Thr Tyr Tyr 
    1010                 1015                 1020             


Cys Gln  Gln Tyr Asp Gly Leu  Pro Leu Thr Phe Gly  Gln Gly Thr 
    1025                 1030                 1035             


Arg Leu  Glu Ile Lys Arg Ser  Arg Gly Gly Gly Gly  Ser Gly Gly 
    1040                 1045                 1050             


Gly Gly  Ser Gly Gly Gly Gly  Ser Leu Glu Met Ala  Gln Val Gln 
    1055                 1060                 1065             


Leu Val  Glu Ser Gly Gly Gly  Leu Val Gln Pro Gly  Gly Ser Leu 
    1070                 1075                 1080             


Arg Leu  Ser Cys Ala Ala Ser  Gly Phe Thr Phe Ser  Asn Tyr Ala 
    1085                 1090                 1095             


Met Ser  Trp Val Arg Gln Ala  Pro Gly Lys Gly Leu  Glu Trp Val 
    1100                 1105                 1110             


Ser Ser  Ile Ser Gly Ser Gly  Gly Ser Thr Tyr Tyr  Ala Asp Ser 
    1115                 1120                 1125             


Val Lys  Gly Arg Phe Thr Ile  Ser Arg Asp Thr Ser  Lys Asn Thr 
    1130                 1135                 1140             


Leu Tyr  Leu Gln Met Asn Ser  Leu Arg Ala Glu Asp  Thr Ala Val 
    1145                 1150                 1155             


Tyr Tyr  Cys Ala Arg Tyr Gly  Ser Ala Ala Trp Met  Asp Ser Trp 
    1160                 1165                 1170             


Gly Gln  Gly Thr Leu Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile 
    1175                 1180                 1185             


Ser Glu  Glu Asp Leu Ala Ala  Ala Ile Glu Val Met  Tyr Pro Pro 
    1190                 1195                 1200             


Pro Tyr  Leu Asp Asn Glu Lys  Ser Asn Gly Thr Ile  Ile His Val 
    1205                 1210                 1215             


Lys Gly  Lys His Leu Cys Pro  Ser Pro Leu Phe Pro  Gly Pro Ser 
    1220                 1225                 1230             


Lys Pro  Phe Trp Val Leu Val  Val Val Gly Gly Val  Leu Ala Cys 
    1235                 1240                 1245             


Tyr Ser  Leu Leu Val Thr Val  Ala Phe Ile Ile Phe  Trp Val Arg 
    1250                 1255                 1260             


Ser Lys  Arg Ser Arg Leu Leu  His Ser Asp Tyr Met  Asn Met Thr 
    1265                 1270                 1275             


Pro Arg  Arg Pro Gly Pro Thr  Arg Lys His Tyr Gln  Pro Tyr Ala 
    1280                 1285                 1290             


Pro Pro  Arg Asp Phe Ala Ala  Tyr Arg Ser 
    1295                 1300             


<210> 7
<211> 1309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
385                 390                 395                 400 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                405                 410                 415     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            420                 425                 430         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        435                 440                 445             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    450                 455                 460                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
465                 470                 475                 480 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                485                 490                 495     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            500                 505                 510         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        515                 520                 525             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    530                 535                 540                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
545                 550                 555                 560 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                565                 570                 575     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            580                 585                 590         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        595                 600                 605             


Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    610                 615                 620                 


Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His 
625                 630                 635                 640 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                645                 650                 655     


Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro 
            660                 665                 670         


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        675                 680                 685             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    690                 695                 700                 


Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
705                 710                 715                 720 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                725                 730                 735     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            740                 745                 750         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        755                 760                 765             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    770                 775                 780                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
785                 790                 795                 800 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                805                 810                 815     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Ile Lys Thr Asp 
            820                 825                 830         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        835                 840                 845             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    850                 855                 860                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
865                 870                 875                 880 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser 
                885                 890                 895     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            900                 905                 910         


Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu 
        915                 920                 925             


Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro 
    930                 935                 940                 


Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
945                 950                 955                 960 


Ala Ser His Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                965                 970                 975     


Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr 
            980                 985                 990         


Gly Val Pro Ser Arg Phe Ser Gly  Arg Gly Ser Gly Thr  Asp Phe Thr 
        995                 1000                 1005             


Leu Thr  Ile Ser Ser Leu Gln  Pro Glu Asp Ile Ala  Thr Tyr Tyr 
    1010                 1015                 1020             


Cys Gln  Gln Tyr Asp Gly Leu  Pro Leu Thr Phe Gly  Gln Gly Thr 
    1025                 1030                 1035             


Arg Leu  Glu Ile Lys Arg Ser  Arg Gly Gly Gly Gly  Ser Gly Gly 
    1040                 1045                 1050             


Gly Gly  Ser Gly Gly Gly Gly  Ser Leu Glu Met Ala  Gln Val Gln 
    1055                 1060                 1065             


Leu Val  Glu Ser Gly Gly Gly  Leu Val Gln Pro Gly  Gly Ser Leu 
    1070                 1075                 1080             


Arg Leu  Ser Cys Ala Ala Ser  Gly Phe Thr Phe Ser  Asn Tyr Ala 
    1085                 1090                 1095             


Met Ser  Trp Val Arg Gln Ala  Pro Gly Lys Gly Leu  Glu Trp Val 
    1100                 1105                 1110             


Ser Ser  Ile Ser Gly Ser Gly  Gly Ser Thr Tyr Tyr  Ala Asp Ser 
    1115                 1120                 1125             


Val Lys  Gly Arg Phe Thr Ile  Ser Arg Asp Thr Ser  Lys Asn Thr 
    1130                 1135                 1140             


Leu Tyr  Leu Gln Met Asn Ser  Leu Arg Ala Glu Asp  Thr Ala Val 
    1145                 1150                 1155             


Tyr Tyr  Cys Ala Arg Tyr Gly  Ser Ala Ala Trp Met  Asp Ser Trp 
    1160                 1165                 1170             


Gly Gln  Gly Thr Leu Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile 
    1175                 1180                 1185             


Ser Glu  Glu Asp Leu Ala Ala  Ala Thr Gly Thr Thr  Thr Pro Ala 
    1190                 1195                 1200             


Pro Arg  Pro Pro Thr Pro Ala  Pro Thr Ile Ala Ser  Gln Pro Leu 
    1205                 1210                 1215             


Ser Leu  Arg Pro Glu Ala Cys  Arg Pro Ala Ala Gly  Gly Ala Val 
    1220                 1225                 1230             


His Thr  Arg Gly Leu Asp Phe  Ala Cys Asp Ile Tyr  Ile Trp Ala 
    1235                 1240                 1245             


Pro Leu  Ala Gly Thr Cys Gly  Val Leu Leu Leu Ser  Leu Val Ile 
    1250                 1255                 1260             


Thr Leu  Tyr Cys Lys Arg Gly  Arg Lys Lys Leu Leu  Tyr Ile Phe 
    1265                 1270                 1275             


Lys Gln  Pro Phe Met Arg Pro  Val Gln Thr Thr Gln  Glu Glu Asp 
    1280                 1285                 1290             


Gly Cys  Ser Cys Arg Phe Pro  Glu Glu Glu Glu Gly  Gly Cys Glu 
    1295                 1300                 1305             


Leu 
    


<210> 8
<211> 1292
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
385                 390                 395                 400 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                405                 410                 415     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            420                 425                 430         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        435                 440                 445             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    450                 455                 460                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
465                 470                 475                 480 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                485                 490                 495     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            500                 505                 510         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        515                 520                 525             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    530                 535                 540                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
545                 550                 555                 560 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                565                 570                 575     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            580                 585                 590         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        595                 600                 605             


Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    610                 615                 620                 


Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His 
625                 630                 635                 640 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                645                 650                 655     


Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro 
            660                 665                 670         


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        675                 680                 685             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    690                 695                 700                 


Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
705                 710                 715                 720 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                725                 730                 735     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            740                 745                 750         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        755                 760                 765             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    770                 775                 780                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
785                 790                 795                 800 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                805                 810                 815     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Ile Lys Thr Asp 
            820                 825                 830         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        835                 840                 845             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    850                 855                 860                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
865                 870                 875                 880 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser 
                885                 890                 895     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            900                 905                 910         


Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu 
        915                 920                 925             


Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro 
    930                 935                 940                 


Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
945                 950                 955                 960 


Ala Ser His Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                965                 970                 975     


Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr 
            980                 985                 990         


Gly Val Pro Ser Arg Phe Ser Gly  Arg Gly Ser Gly Thr  Asp Phe Thr 
        995                 1000                 1005             


Leu Thr  Ile Ser Ser Leu Gln  Pro Glu Asp Ile Ala  Thr Tyr Tyr 
    1010                 1015                 1020             


Cys Gln  Gln Tyr Asp Gly Leu  Pro Leu Thr Phe Gly  Gln Gly Thr 
    1025                 1030                 1035             


Arg Leu  Glu Ile Lys Arg Ser  Arg Gly Gly Gly Gly  Ser Gly Gly 
    1040                 1045                 1050             


Gly Gly  Ser Gly Gly Gly Gly  Ser Leu Glu Met Ala  Gln Val Gln 
    1055                 1060                 1065             


Leu Val  Glu Ser Gly Gly Gly  Leu Val Gln Pro Gly  Gly Ser Leu 
    1070                 1075                 1080             


Arg Leu  Ser Cys Ala Ala Ser  Gly Phe Thr Phe Ser  Asn Tyr Ala 
    1085                 1090                 1095             


Met Ser  Trp Val Arg Gln Ala  Pro Gly Lys Gly Leu  Glu Trp Val 
    1100                 1105                 1110             


Ser Ser  Ile Ser Gly Ser Gly  Gly Ser Thr Tyr Tyr  Ala Asp Ser 
    1115                 1120                 1125             


Val Lys  Gly Arg Phe Thr Ile  Ser Arg Asp Thr Ser  Lys Asn Thr 
    1130                 1135                 1140             


Leu Tyr  Leu Gln Met Asn Ser  Leu Arg Ala Glu Asp  Thr Ala Val 
    1145                 1150                 1155             


Tyr Tyr  Cys Ala Arg Tyr Gly  Ser Ala Ala Trp Met  Asp Ser Trp 
    1160                 1165                 1170             


Gly Gln  Gly Thr Leu Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile 
    1175                 1180                 1185             


Ser Glu  Glu Asp Leu Ala Ala  Ala Thr Gly Pro Ala  Asp Leu Ser 
    1190                 1195                 1200             


Pro Gly  Ala Ser Ser Val Thr  Pro Pro Ala Pro Ala  Arg Glu Pro 
    1205                 1210                 1215             


Gly His  Ser Pro Gln Ile Ile  Ser Phe Phe Leu Ala  Leu Thr Ser 
    1220                 1225                 1230             


Thr Ala  Leu Leu Phe Leu Leu  Phe Phe Leu Thr Leu  Arg Phe Ser 
    1235                 1240                 1245             


Val Val  Lys Arg Gly Arg Lys  Lys Leu Leu Tyr Ile  Phe Lys Gln 
    1250                 1255                 1260             


Pro Phe  Met Arg Pro Val Gln  Thr Thr Gln Glu Glu  Asp Gly Cys 
    1265                 1270                 1275             


Ser Cys  Arg Phe Pro Glu Glu  Glu Glu Gly Gly Cys  Glu Leu 
    1280                 1285                 1290         


<210> 9
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
385                 390                 395                 400 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                405                 410                 415     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            420                 425                 430         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        435                 440                 445             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    450                 455                 460                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
465                 470                 475                 480 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                485                 490                 495     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            500                 505                 510         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        515                 520                 525             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    530                 535                 540                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
545                 550                 555                 560 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                565                 570                 575     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            580                 585                 590         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        595                 600                 605             


Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    610                 615                 620                 


Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His 
625                 630                 635                 640 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                645                 650                 655     


Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro 
            660                 665                 670         


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        675                 680                 685             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    690                 695                 700                 


Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
705                 710                 715                 720 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                725                 730                 735     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            740                 745                 750         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        755                 760                 765             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    770                 775                 780                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
785                 790                 795                 800 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                805                 810                 815     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Ile Lys Thr Asp 
            820                 825                 830         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        835                 840                 845             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    850                 855                 860                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
865                 870                 875                 880 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser 
                885                 890                 895     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            900                 905                 910         


Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu 
        915                 920                 925             


Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro 
    930                 935                 940                 


Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
945                 950                 955                 960 


Ala Ser His Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                965                 970                 975     


Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr 
            980                 985                 990         


Gly Val Pro Ser Arg Phe Ser Gly  Arg Gly Ser Gly Thr  Asp Phe Thr 
        995                 1000                 1005             


Leu Thr  Ile Ser Ser Leu Gln  Pro Glu Asp Ile Ala  Thr Tyr Tyr 
    1010                 1015                 1020             


Cys Gln  Gln Tyr Asp Gly Leu  Pro Leu Thr Phe Gly  Gln Gly Thr 
    1025                 1030                 1035             


Arg Leu  Glu Ile Lys Arg Ser  Arg Gly Gly Gly Gly  Ser Gly Gly 
    1040                 1045                 1050             


Gly Gly  Ser Gly Gly Gly Gly  Ser Leu Glu Met Ala  Gln Val Gln 
    1055                 1060                 1065             


Leu Val  Glu Ser Gly Gly Gly  Leu Val Gln Pro Gly  Gly Ser Leu 
    1070                 1075                 1080             


Arg Leu  Ser Cys Ala Ala Ser  Gly Phe Thr Phe Ser  Asn Tyr Ala 
    1085                 1090                 1095             


Met Ser  Trp Val Arg Gln Ala  Pro Gly Lys Gly Leu  Glu Trp Val 
    1100                 1105                 1110             


Ser Ser  Ile Ser Gly Ser Gly  Gly Ser Thr Tyr Tyr  Ala Asp Ser 
    1115                 1120                 1125             


Val Lys  Gly Arg Phe Thr Ile  Ser Arg Asp Thr Ser  Lys Asn Thr 
    1130                 1135                 1140             


Leu Tyr  Leu Gln Met Asn Ser  Leu Arg Ala Glu Asp  Thr Ala Val 
    1145                 1150                 1155             


Tyr Tyr  Cys Ala Arg Tyr Gly  Ser Ala Ala Trp Met  Asp Ser Trp 
    1160                 1165                 1170             


Gly Gln  Gly Thr Leu Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile 
    1175                 1180                 1185             


Ser Glu  Glu Asp Leu Ala Ala  Ala Thr Gly Thr Thr  Thr Pro Ala 
    1190                 1195                 1200             


Pro Arg  Pro Pro Thr Pro Ala  Pro Thr Ile Ala Ser  Gln Pro Leu 
    1205                 1210                 1215             


Ser Leu  Arg Pro Glu Ala Cys  Arg Pro Ala Ala Gly  Gly Ala Val 
    1220                 1225                 1230             


His Thr  Arg Gly Leu Asp Phe  Ala Cys Asp Ile Tyr  Ile Trp Ala 
    1235                 1240                 1245             


Pro Leu  Ala Gly Thr Cys Gly  Val Leu Leu Leu Ser  Leu Val Ile 
    1250                 1255                 1260             


Thr Leu  Tyr Cys Gln Arg Arg  Lys Tyr Arg Ser Asn  Lys Gly Glu 
    1265                 1270                 1275             


Ser Pro  Val Glu Pro Ala Glu  Pro Cys Arg Tyr Ser  Cys Pro Arg 
    1280                 1285                 1290             


Glu Glu  Glu Gly Ser Thr Ile  Pro Ile Gln Glu Asp  Tyr Arg Lys 
    1295                 1300                 1305             


Pro Glu  Pro Ala Cys Ser Pro  
    1310                 1315 


<210> 10
<211> 1317
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
385                 390                 395                 400 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                405                 410                 415     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            420                 425                 430         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        435                 440                 445             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    450                 455                 460                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
465                 470                 475                 480 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                485                 490                 495     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            500                 505                 510         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        515                 520                 525             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    530                 535                 540                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
545                 550                 555                 560 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                565                 570                 575     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            580                 585                 590         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        595                 600                 605             


Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    610                 615                 620                 


Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His 
625                 630                 635                 640 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                645                 650                 655     


Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro 
            660                 665                 670         


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        675                 680                 685             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    690                 695                 700                 


Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
705                 710                 715                 720 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                725                 730                 735     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            740                 745                 750         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        755                 760                 765             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    770                 775                 780                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
785                 790                 795                 800 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                805                 810                 815     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Ile Lys Thr Asp 
            820                 825                 830         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        835                 840                 845             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    850                 855                 860                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
865                 870                 875                 880 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser 
                885                 890                 895     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            900                 905                 910         


Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu 
        915                 920                 925             


Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro 
    930                 935                 940                 


Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
945                 950                 955                 960 


Ala Ser His Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                965                 970                 975     


Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr 
            980                 985                 990         


Gly Val Pro Ser Arg Phe Ser Gly  Arg Gly Ser Gly Thr  Asp Phe Thr 
        995                 1000                 1005             


Leu Thr  Ile Ser Ser Leu Gln  Pro Glu Asp Ile Ala  Thr Tyr Tyr 
    1010                 1015                 1020             


Cys Gln  Gln Tyr Asp Gly Leu  Pro Leu Thr Phe Gly  Gln Gly Thr 
    1025                 1030                 1035             


Arg Leu  Glu Ile Lys Arg Ser  Arg Gly Gly Gly Gly  Ser Gly Gly 
    1040                 1045                 1050             


Gly Gly  Ser Gly Gly Gly Gly  Ser Leu Glu Met Ala  Gln Val Gln 
    1055                 1060                 1065             


Leu Val  Glu Ser Gly Gly Gly  Leu Val Gln Pro Gly  Gly Ser Leu 
    1070                 1075                 1080             


Arg Leu  Ser Cys Ala Ala Ser  Gly Phe Thr Phe Ser  Asn Tyr Ala 
    1085                 1090                 1095             


Met Ser  Trp Val Arg Gln Ala  Pro Gly Lys Gly Leu  Glu Trp Val 
    1100                 1105                 1110             


Ser Ser  Ile Ser Gly Ser Gly  Gly Ser Thr Tyr Tyr  Ala Asp Ser 
    1115                 1120                 1125             


Val Lys  Gly Arg Phe Thr Ile  Ser Arg Asp Thr Ser  Lys Asn Thr 
    1130                 1135                 1140             


Leu Tyr  Leu Gln Met Asn Ser  Leu Arg Ala Glu Asp  Thr Ala Val 
    1145                 1150                 1155             


Tyr Tyr  Cys Ala Arg Tyr Gly  Ser Ala Ala Trp Met  Asp Ser Trp 
    1160                 1165                 1170             


Gly Gln  Gly Thr Leu Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile 
    1175                 1180                 1185             


Ser Glu  Glu Asp Leu Ala Ala  Ala Thr Gly Pro Thr  His Leu Pro 
    1190                 1195                 1200             


Tyr Val  Ser Glu Met Leu Glu  Ala Arg Thr Ala Gly  His Met Gln 
    1205                 1210                 1215             


Thr Leu  Ala Asp Phe Arg Gln  Leu Pro Ala Arg Thr  Leu Ser Thr 
    1220                 1225                 1230             


His Trp  Pro Pro Gln Arg Ser  Leu Cys Ser Ser Asp  Phe Ile Arg 
    1235                 1240                 1245             


Ile Leu  Val Ile Phe Ser Gly  Met Phe Leu Val Phe  Thr Leu Ala 
    1250                 1255                 1260             


Gly Ala  Leu Phe Leu His Gln  Arg Arg Lys Tyr Arg  Ser Asn Lys 
    1265                 1270                 1275             


Gly Glu  Ser Pro Val Glu Pro  Ala Glu Pro Cys Arg  Tyr Ser Cys 
    1280                 1285                 1290             


Pro Arg  Glu Glu Glu Gly Ser  Thr Ile Pro Ile Gln  Glu Asp Tyr 
    1295                 1300                 1305             


Arg Lys  Pro Glu Pro Ala Cys  Ser Pro 
    1310                 1315         


<210> 11
<211> 1455
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
385                 390                 395                 400 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                405                 410                 415     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            420                 425                 430         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        435                 440                 445             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    450                 455                 460                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
465                 470                 475                 480 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                485                 490                 495     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            500                 505                 510         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        515                 520                 525             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    530                 535                 540                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
545                 550                 555                 560 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                565                 570                 575     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            580                 585                 590         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        595                 600                 605             


Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    610                 615                 620                 


Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His 
625                 630                 635                 640 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                645                 650                 655     


Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro 
            660                 665                 670         


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        675                 680                 685             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    690                 695                 700                 


Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
705                 710                 715                 720 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                725                 730                 735     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            740                 745                 750         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        755                 760                 765             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    770                 775                 780                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
785                 790                 795                 800 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                805                 810                 815     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Ile Lys Thr Asp 
            820                 825                 830         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        835                 840                 845             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    850                 855                 860                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
865                 870                 875                 880 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser 
                885                 890                 895     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            900                 905                 910         


Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu 
        915                 920                 925             


Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro 
    930                 935                 940                 


Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
945                 950                 955                 960 


Ala Ser His Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                965                 970                 975     


Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr 
            980                 985                 990         


Gly Val Pro Ser Arg Phe Ser Gly  Arg Gly Ser Gly Thr  Asp Phe Thr 
        995                 1000                 1005             


Leu Thr  Ile Ser Ser Leu Gln  Pro Glu Asp Ile Ala  Thr Tyr Tyr 
    1010                 1015                 1020             


Cys Gln  Gln Tyr Asp Gly Leu  Pro Leu Thr Phe Gly  Gln Gly Thr 
    1025                 1030                 1035             


Arg Leu  Glu Ile Lys Arg Ser  Arg Gly Gly Gly Gly  Ser Gly Gly 
    1040                 1045                 1050             


Gly Gly  Ser Gly Gly Gly Gly  Ser Leu Glu Met Ala  Gln Val Gln 
    1055                 1060                 1065             


Leu Val  Glu Ser Gly Gly Gly  Leu Val Gln Pro Gly  Gly Ser Leu 
    1070                 1075                 1080             


Arg Leu  Ser Cys Ala Ala Ser  Gly Phe Thr Phe Ser  Asn Tyr Ala 
    1085                 1090                 1095             


Met Ser  Trp Val Arg Gln Ala  Pro Gly Lys Gly Leu  Glu Trp Val 
    1100                 1105                 1110             


Ser Ser  Ile Ser Gly Ser Gly  Gly Ser Thr Tyr Tyr  Ala Asp Ser 
    1115                 1120                 1125             


Val Lys  Gly Arg Phe Thr Ile  Ser Arg Asp Thr Ser  Lys Asn Thr 
    1130                 1135                 1140             


Leu Tyr  Leu Gln Met Asn Ser  Leu Arg Ala Glu Asp  Thr Ala Val 
    1145                 1150                 1155             


Tyr Tyr  Cys Ala Arg Tyr Gly  Ser Ala Ala Trp Met  Asp Ser Trp 
    1160                 1165                 1170             


Gly Gln  Gly Thr Leu Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile 
    1175                 1180                 1185             


Ser Glu  Glu Asp Leu Ala Ala  Ala Thr Gly Thr Thr  Thr Pro Ala 
    1190                 1195                 1200             


Pro Arg  Pro Pro Thr Pro Ala  Pro Thr Ile Ala Ser  Gln Pro Leu 
    1205                 1210                 1215             


Ser Leu  Arg Pro Glu Ala Cys  Arg Pro Ala Ala Gly  Gly Ala Val 
    1220                 1225                 1230             


His Thr  Arg Gly Leu Asp Phe  Ala Cys Asp Ile Tyr  Ile Trp Ala 
    1235                 1240                 1245             


Pro Leu  Ala Gly Thr Cys Gly  Val Leu Leu Leu Ser  Leu Val Ile 
    1250                 1255                 1260             


Thr Leu  Tyr Cys His Arg Arg  Ala Cys Arg Lys Arg  Ile Arg Gln 
    1265                 1270                 1275             


Lys Leu  His Leu Cys Tyr Pro  Val Gln Thr Ser Gln  Pro Lys Leu 
    1280                 1285                 1290             


Glu Leu  Val Asp Ser Arg Pro  Arg Arg Ser Ser Thr  Gln Leu Arg 
    1295                 1300                 1305             


Ser Gly  Ala Ser Val Thr Glu  Pro Val Ala Glu Glu  Arg Gly Leu 
    1310                 1315                 1320             


Met Ser  Gln Pro Leu Met Glu  Thr Cys His Ser Val  Gly Ala Ala 
    1325                 1330                 1335             


Tyr Leu  Glu Ser Leu Pro Leu  Gln Asp Ala Ser Pro  Ala Gly Gly 
    1340                 1345                 1350             


Pro Ser  Ser Pro Arg Asp Leu  Pro Glu Pro Arg Val  Ser Thr Glu 
    1355                 1360                 1365             


His Thr  Asn Asn Lys Ile Glu  Lys Ile Tyr Ile Met  Lys Ala Asp 
    1370                 1375                 1380             


Thr Val  Ile Val Gly Thr Val  Lys Ala Glu Leu Pro  Glu Gly Arg 
    1385                 1390                 1395             


Gly Leu  Ala Gly Pro Ala Glu  Pro Glu Leu Glu Glu  Glu Leu Glu 
    1400                 1405                 1410             


Ala Asp  His Thr Pro His Tyr  Pro Glu Gln Glu Thr  Glu Pro Pro 
    1415                 1420                 1425             


Leu Gly  Ser Cys Ser Asp Val  Met Leu Ser Val Glu  Glu Glu Gly 
    1430                 1435                 1440             


Lys Glu  Asp Pro Leu Pro Thr  Ala Ala Ser Gly Lys  
    1445                 1450                 1455 


<210> 12
<211> 1468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
385                 390                 395                 400 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                405                 410                 415     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            420                 425                 430         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        435                 440                 445             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    450                 455                 460                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
465                 470                 475                 480 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                485                 490                 495     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            500                 505                 510         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        515                 520                 525             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    530                 535                 540                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
545                 550                 555                 560 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                565                 570                 575     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            580                 585                 590         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        595                 600                 605             


Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    610                 615                 620                 


Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His 
625                 630                 635                 640 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                645                 650                 655     


Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro 
            660                 665                 670         


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        675                 680                 685             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    690                 695                 700                 


Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
705                 710                 715                 720 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                725                 730                 735     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            740                 745                 750         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        755                 760                 765             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    770                 775                 780                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
785                 790                 795                 800 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                805                 810                 815     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Ile Lys Thr Asp 
            820                 825                 830         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        835                 840                 845             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    850                 855                 860                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
865                 870                 875                 880 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser 
                885                 890                 895     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            900                 905                 910         


Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu 
        915                 920                 925             


Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro 
    930                 935                 940                 


Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
945                 950                 955                 960 


Ala Ser His Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                965                 970                 975     


Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr 
            980                 985                 990         


Gly Val Pro Ser Arg Phe Ser Gly  Arg Gly Ser Gly Thr  Asp Phe Thr 
        995                 1000                 1005             


Leu Thr  Ile Ser Ser Leu Gln  Pro Glu Asp Ile Ala  Thr Tyr Tyr 
    1010                 1015                 1020             


Cys Gln  Gln Tyr Asp Gly Leu  Pro Leu Thr Phe Gly  Gln Gly Thr 
    1025                 1030                 1035             


Arg Leu  Glu Ile Lys Arg Ser  Arg Gly Gly Gly Gly  Ser Gly Gly 
    1040                 1045                 1050             


Gly Gly  Ser Gly Gly Gly Gly  Ser Leu Glu Met Ala  Gln Val Gln 
    1055                 1060                 1065             


Leu Val  Glu Ser Gly Gly Gly  Leu Val Gln Pro Gly  Gly Ser Leu 
    1070                 1075                 1080             


Arg Leu  Ser Cys Ala Ala Ser  Gly Phe Thr Phe Ser  Asn Tyr Ala 
    1085                 1090                 1095             


Met Ser  Trp Val Arg Gln Ala  Pro Gly Lys Gly Leu  Glu Trp Val 
    1100                 1105                 1110             


Ser Ser  Ile Ser Gly Ser Gly  Gly Ser Thr Tyr Tyr  Ala Asp Ser 
    1115                 1120                 1125             


Val Lys  Gly Arg Phe Thr Ile  Ser Arg Asp Thr Ser  Lys Asn Thr 
    1130                 1135                 1140             


Leu Tyr  Leu Gln Met Asn Ser  Leu Arg Ala Glu Asp  Thr Ala Val 
    1145                 1150                 1155             


Tyr Tyr  Cys Ala Arg Tyr Gly  Ser Ala Ala Trp Met  Asp Ser Trp 
    1160                 1165                 1170             


Gly Gln  Gly Thr Leu Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile 
    1175                 1180                 1185             


Ser Glu  Glu Asp Leu Ala Ala  Ala Thr Gly Ala Pro  Pro Leu Gly 
    1190                 1195                 1200             


Thr Gln  Pro Asp Cys Asn Pro  Thr Pro Glu Asn Gly  Glu Ala Pro 
    1205                 1210                 1215             


Ala Ser  Thr Ser Pro Thr Gln  Ser Leu Leu Val Asp  Ser Gln Ala 
    1220                 1225                 1230             


Ser Lys  Thr Leu Pro Ile Pro  Thr Ser Ala Pro Val  Ala Leu Ser 
    1235                 1240                 1245             


Ser Thr  Gly Lys Pro Val Leu  Asp Ala Gly Pro Val  Leu Phe Trp 
    1250                 1255                 1260             


Val Ile  Leu Val Leu Val Val  Val Val Gly Ser Ser  Ala Phe Leu 
    1265                 1270                 1275             


Leu Cys  His Arg Arg Ala Cys  Arg Lys Arg Ile Arg  Gln Lys Leu 
    1280                 1285                 1290             


His Leu  Cys Tyr Pro Val Gln  Thr Ser Gln Pro Lys  Leu Glu Leu 
    1295                 1300                 1305             


Val Asp  Ser Arg Pro Arg Arg  Ser Ser Thr Gln Leu  Arg Ser Gly 
    1310                 1315                 1320             


Ala Ser  Val Thr Glu Pro Val  Ala Glu Glu Arg Gly  Leu Met Ser 
    1325                 1330                 1335             


Gln Pro  Leu Met Glu Thr Cys  His Ser Val Gly Ala  Ala Tyr Leu 
    1340                 1345                 1350             


Glu Ser  Leu Pro Leu Gln Asp  Ala Ser Pro Ala Gly  Gly Pro Ser 
    1355                 1360                 1365             


Ser Pro  Arg Asp Leu Pro Glu  Pro Arg Val Ser Thr  Glu His Thr 
    1370                 1375                 1380             


Asn Asn  Lys Ile Glu Lys Ile  Tyr Ile Met Lys Ala  Asp Thr Val 
    1385                 1390                 1395             


Ile Val  Gly Thr Val Lys Ala  Glu Leu Pro Glu Gly  Arg Gly Leu 
    1400                 1405                 1410             


Ala Gly  Pro Ala Glu Pro Glu  Leu Glu Glu Glu Leu  Glu Ala Asp 
    1415                 1420                 1425             


His Thr  Pro His Tyr Pro Glu  Gln Glu Thr Glu Pro  Pro Leu Gly 
    1430                 1435                 1440             


Ser Cys  Ser Asp Val Met Leu  Ser Val Glu Glu Glu  Gly Lys Glu 
    1445                 1450                 1455             


Asp Pro  Leu Pro Thr Ala Ala  Ser Gly Lys 
    1460                 1465             


<210> 13
<211> 1309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
385                 390                 395                 400 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                405                 410                 415     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            420                 425                 430         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        435                 440                 445             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    450                 455                 460                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
465                 470                 475                 480 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                485                 490                 495     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            500                 505                 510         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        515                 520                 525             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    530                 535                 540                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
545                 550                 555                 560 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                565                 570                 575     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            580                 585                 590         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        595                 600                 605             


Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    610                 615                 620                 


Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His 
625                 630                 635                 640 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                645                 650                 655     


Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro 
            660                 665                 670         


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        675                 680                 685             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    690                 695                 700                 


Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
705                 710                 715                 720 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                725                 730                 735     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            740                 745                 750         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        755                 760                 765             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    770                 775                 780                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
785                 790                 795                 800 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                805                 810                 815     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Ile Lys Thr Asp 
            820                 825                 830         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        835                 840                 845             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    850                 855                 860                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
865                 870                 875                 880 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser 
                885                 890                 895     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            900                 905                 910         


Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu 
        915                 920                 925             


Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro 
    930                 935                 940                 


Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
945                 950                 955                 960 


Ala Ser His Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                965                 970                 975     


Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr 
            980                 985                 990         


Gly Val Pro Ser Arg Phe Ser Gly  Arg Gly Ser Gly Thr  Asp Phe Thr 
        995                 1000                 1005             


Leu Thr  Ile Ser Ser Leu Gln  Pro Glu Asp Ile Ala  Thr Tyr Tyr 
    1010                 1015                 1020             


Cys Gln  Gln Tyr Asp Gly Leu  Pro Leu Thr Phe Gly  Gln Gly Thr 
    1025                 1030                 1035             


Arg Leu  Glu Ile Lys Arg Ser  Arg Gly Gly Gly Gly  Ser Gly Gly 
    1040                 1045                 1050             


Gly Gly  Ser Gly Gly Gly Gly  Ser Leu Glu Met Ala  Gln Val Gln 
    1055                 1060                 1065             


Leu Val  Glu Ser Gly Gly Gly  Leu Val Gln Pro Gly  Gly Ser Leu 
    1070                 1075                 1080             


Arg Leu  Ser Cys Ala Ala Ser  Gly Phe Thr Phe Ser  Asn Tyr Ala 
    1085                 1090                 1095             


Met Ser  Trp Val Arg Gln Ala  Pro Gly Lys Gly Leu  Glu Trp Val 
    1100                 1105                 1110             


Ser Ser  Ile Ser Gly Ser Gly  Gly Ser Thr Tyr Tyr  Ala Asp Ser 
    1115                 1120                 1125             


Val Lys  Gly Arg Phe Thr Ile  Ser Arg Asp Thr Ser  Lys Asn Thr 
    1130                 1135                 1140             


Leu Tyr  Leu Gln Met Asn Ser  Leu Arg Ala Glu Asp  Thr Ala Val 
    1145                 1150                 1155             


Tyr Tyr  Cys Ala Arg Tyr Gly  Ser Ala Ala Trp Met  Asp Ser Trp 
    1160                 1165                 1170             


Gly Gln  Gly Thr Leu Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile 
    1175                 1180                 1185             


Ser Glu  Glu Asp Leu Ala Ala  Ala Thr Gly Thr Thr  Thr Pro Ala 
    1190                 1195                 1200             


Pro Arg  Pro Pro Thr Pro Ala  Pro Thr Ile Ala Ser  Gln Pro Leu 
    1205                 1210                 1215             


Ser Leu  Arg Pro Glu Ala Cys  Arg Pro Ala Ala Gly  Gly Ala Val 
    1220                 1225                 1230             


His Thr  Arg Gly Leu Asp Phe  Ala Cys Asp Ile Tyr  Ile Trp Ala 
    1235                 1240                 1245             


Pro Leu  Ala Gly Thr Cys Gly  Val Leu Leu Leu Ser  Leu Val Ile 
    1250                 1255                 1260             


Thr Leu  Tyr Cys Ala Leu Tyr  Leu Leu Arg Arg Asp  Gln Arg Leu 
    1265                 1270                 1275             


Pro Pro  Asp Ala His Lys Pro  Pro Gly Gly Gly Ser  Phe Arg Thr 
    1280                 1285                 1290             


Pro Ile  Gln Glu Glu Gln Ala  Asp Ala His Ser Thr  Leu Ala Lys 
    1295                 1300                 1305             


Ile 
    


<210> 14
<211> 1308
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
385                 390                 395                 400 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                405                 410                 415     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            420                 425                 430         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        435                 440                 445             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    450                 455                 460                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
465                 470                 475                 480 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                485                 490                 495     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            500                 505                 510         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        515                 520                 525             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    530                 535                 540                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
545                 550                 555                 560 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                565                 570                 575     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            580                 585                 590         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        595                 600                 605             


Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    610                 615                 620                 


Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His 
625                 630                 635                 640 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                645                 650                 655     


Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro 
            660                 665                 670         


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        675                 680                 685             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    690                 695                 700                 


Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
705                 710                 715                 720 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                725                 730                 735     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            740                 745                 750         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        755                 760                 765             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    770                 775                 780                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
785                 790                 795                 800 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                805                 810                 815     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Ile Lys Thr Asp 
            820                 825                 830         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        835                 840                 845             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    850                 855                 860                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
865                 870                 875                 880 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser 
                885                 890                 895     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            900                 905                 910         


Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu 
        915                 920                 925             


Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro 
    930                 935                 940                 


Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
945                 950                 955                 960 


Ala Ser His Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                965                 970                 975     


Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr 
            980                 985                 990         


Gly Val Pro Ser Arg Phe Ser Gly  Arg Gly Ser Gly Thr  Asp Phe Thr 
        995                 1000                 1005             


Leu Thr  Ile Ser Ser Leu Gln  Pro Glu Asp Ile Ala  Thr Tyr Tyr 
    1010                 1015                 1020             


Cys Gln  Gln Tyr Asp Gly Leu  Pro Leu Thr Phe Gly  Gln Gly Thr 
    1025                 1030                 1035             


Arg Leu  Glu Ile Lys Arg Ser  Arg Gly Gly Gly Gly  Ser Gly Gly 
    1040                 1045                 1050             


Gly Gly  Ser Gly Gly Gly Gly  Ser Leu Glu Met Ala  Gln Val Gln 
    1055                 1060                 1065             


Leu Val  Glu Ser Gly Gly Gly  Leu Val Gln Pro Gly  Gly Ser Leu 
    1070                 1075                 1080             


Arg Leu  Ser Cys Ala Ala Ser  Gly Phe Thr Phe Ser  Asn Tyr Ala 
    1085                 1090                 1095             


Met Ser  Trp Val Arg Gln Ala  Pro Gly Lys Gly Leu  Glu Trp Val 
    1100                 1105                 1110             


Ser Ser  Ile Ser Gly Ser Gly  Gly Ser Thr Tyr Tyr  Ala Asp Ser 
    1115                 1120                 1125             


Val Lys  Gly Arg Phe Thr Ile  Ser Arg Asp Thr Ser  Lys Asn Thr 
    1130                 1135                 1140             


Leu Tyr  Leu Gln Met Asn Ser  Leu Arg Ala Glu Asp  Thr Ala Val 
    1145                 1150                 1155             


Tyr Tyr  Cys Ala Arg Tyr Gly  Ser Ala Ala Trp Met  Asp Ser Trp 
    1160                 1165                 1170             


Gly Gln  Gly Thr Leu Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile 
    1175                 1180                 1185             


Ser Glu  Glu Asp Leu Ala Ala  Ala Thr Gly Asp Arg  Asp Pro Pro 
    1190                 1195                 1200             


Ala Thr  Gln Pro Gln Glu Thr  Gln Gly Pro Pro Ala  Arg Pro Ile 
    1205                 1210                 1215             


Thr Val  Gln Pro Thr Glu Ala  Trp Pro Arg Thr Ser  Gln Gly Pro 
    1220                 1225                 1230             


Ser Thr  Arg Pro Val Glu Val  Pro Gly Gly Arg Ala  Val Ala Ala 
    1235                 1240                 1245             


Ile Leu  Gly Leu Gly Leu Val  Leu Gly Leu Leu Gly  Pro Leu Ala 
    1250                 1255                 1260             


Ile Leu  Leu Ala Leu Tyr Leu  Leu Arg Arg Asp Gln  Arg Leu Pro 
    1265                 1270                 1275             


Pro Asp  Ala His Lys Pro Pro  Gly Gly Gly Ser Phe  Arg Thr Pro 
    1280                 1285                 1290             


Ile Gln  Glu Glu Gln Ala Asp  Ala His Ser Thr Leu  Ala Lys Ile 
    1295                 1300                 1305             


<210> 15
<211> 906
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
            900                 905     


<210> 16
<211> 911
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
        275                 280                 285             


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
    290                 295                 300                 


Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
                325                 330                 335     


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
            340                 345                 350         


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
        355                 360                 365             


Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met 
    370                 375                 380                 


Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly 
385                 390                 395                 400 


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
                405                 410                 415     


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
            420                 425                 430         


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        435                 440                 445             


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    450                 455                 460                 


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
465                 470                 475                 480 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
                485                 490                 495     


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val 
            500                 505                 510         


Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr 
        515                 520                 525             


Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr 
    530                 535                 540                 


Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu 
545                 550                 555                 560 


Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe 
                565                 570                 575     


Phe Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr 
            580                 585                 590         


Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
        595                 600                 605             


Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp 
    610                 615                 620                 


Val Pro Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val 
625                 630                 635                 640 


Ser Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn 
                645                 650                 655     


Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
            660                 665                 670         


Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro 
        675                 680                 685             


Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
    690                 695                 700                 


Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp 
705                 710                 715                 720 


Asp Ser Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
                725                 730                 735     


Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro 
            740                 745                 750         


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
        755                 760                 765             


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly 
    770                 775                 780                 


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser 
785                 790                 795                 800 


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
                805                 810                 815     


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
            820                 825                 830         


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr 
        835                 840                 845             


Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn 
    850                 855                 860                 


Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr 
865                 870                 875                 880 


Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys 
                885                 890                 895     


Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
            900                 905                 910     


<210> 17
<211> 944
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Pro Leu Gly Asp 
            260                 265                 270         


Thr Thr His Thr Ser Gly Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        275                 280                 285             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    290                 295                 300                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
305                 310                 315                 320 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                325                 330                 335     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            340                 345                 350         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        355                 360                 365             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
    370                 375                 380                 


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
385                 390                 395                 400 


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
                405                 410                 415     


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
            420                 425                 430         


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
        435                 440                 445             


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
    450                 455                 460                 


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
465                 470                 475                 480 


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
                485                 490                 495     


Pro Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser 
            500                 505                 510         


Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
        515                 520                 525             


Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    530                 535                 540                 


Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu 
545                 550                 555                 560 


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
                565                 570                 575     


Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp 
            580                 585                 590         


Ser Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        595                 600                 605             


Leu Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala 
625                 630                 635                 640 


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
                645                 650                 655     


Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro 
            660                 665                 670         


Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp 
        675                 680                 685             


Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
    690                 695                 700                 


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
705                 710                 715                 720 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly 
                725                 730                 735     


Gly Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly 
            740                 745                 750         


Gln Gly Thr Leu Val Thr Val Ser Ser Thr Pro Leu Gly Asp Thr Thr 
        755                 760                 765             


His Thr Ser Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro 
    770                 775                 780                 


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
785                 790                 795                 800 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                805                 810                 815     


Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
            820                 825                 830         


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        835                 840                 845             


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    850                 855                 860                 


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Pro Ile Lys 
865                 870                 875                 880 


Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala 
                885                 890                 895     


Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met 
            900                 905                 910         


Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr 
        915                 920                 925             


Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
    930                 935                 940                 


<210> 18
<211> 952
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Thr Lys Gly Pro 
        275                 280                 285             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    290                 295                 300                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
305                 310                 315                 320 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                325                 330                 335     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            340                 345                 350         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        355                 360                 365             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    370                 375                 380                 


Cys Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr 
385                 390                 395                 400 


Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile 
                405                 410                 415     


Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu 
            420                 425                 430         


Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala 
        435                 440                 445             


Lys Leu Phe Phe Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val 
    450                 455                 460                 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
465                 470                 475                 480 


Ser Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                485                 490                 495     


Leu Leu Trp Val Pro Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro 
            500                 505                 510         


Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly 
        515                 520                 525             


Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro 
    530                 535                 540                 


Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser 
545                 550                 555                 560 


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
                565                 570                 575     


Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys 
            580                 585                 590         


Gln Val Trp Asp Ser Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr 
        595                 600                 605             


Lys Leu Thr Val Leu Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val 
625                 630                 635                 640 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser 
                645                 650                 655     


Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val 
            660                 665                 670         


Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro 
        675                 680                 685             


Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr 
    690                 695                 700                 


Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser 
705                 710                 715                 720 


Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp 
                725                 730                 735     


Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu 
            740                 745                 750         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        755                 760                 765             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro Lys Ala 
    770                 775                 780                 


Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
785                 790                 795                 800 


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
                805                 810                 815     


Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala Gly Val 
            820                 825                 830         


Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
        835                 840                 845             


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
    850                 855                 860                 


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
865                 870                 875                 880 


Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro 
                885                 890                 895     


Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu 
            900                 905                 910         


Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser 
        915                 920                 925             


Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala 
    930                 935                 940                 


Phe Cys Cys Asn Gly Glu Lys Ser 
945                 950         


<210> 19
<211> 953
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Thr Lys Gly Pro 
        275                 280                 285             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    290                 295                 300                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
305                 310                 315                 320 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                325                 330                 335     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Glu Leu Val Ser Val Val Thr 
            340                 345                 350         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        355                 360                 365             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    370                 375                 380                 


Cys Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr 
385                 390                 395                 400 


Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile 
                405                 410                 415     


Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu 
            420                 425                 430         


Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala 
        435                 440                 445             


Lys Leu Phe Phe Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val 
    450                 455                 460                 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
465                 470                 475                 480 


Ser Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                485                 490                 495     


Leu Leu Trp Val Pro Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro 
            500                 505                 510         


Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly 
        515                 520                 525             


Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro 
    530                 535                 540                 


Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser 
545                 550                 555                 560 


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
                565                 570                 575     


Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys 
            580                 585                 590         


Gln Val Trp Asp Ser Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr 
        595                 600                 605             


Lys Leu Thr Val Leu Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val 
625                 630                 635                 640 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser 
                645                 650                 655     


Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val 
            660                 665                 670         


Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro 
        675                 680                 685             


Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr 
    690                 695                 700                 


Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser 
705                 710                 715                 720 


Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp 
                725                 730                 735     


Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu 
            740                 745                 750         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        755                 760                 765             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Val Ala Ala 
    770                 775                 780                 


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
785                 790                 795                 800 


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
                805                 810                 815     


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
            820                 825                 830         


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Leu 
        835                 840                 845             


Ser Ser Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
    850                 855                 860                 


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
865                 870                 875                 880 


Phe Asn Arg Gly Glu Cys Pro Ile Lys Thr Asp Val Ile Thr Met Asp 
                885                 890                 895     


Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln 
            900                 905                 910         


Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys 
        915                 920                 925             


Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr 
    930                 935                 940                 


Ala Phe Cys Cys Asn Gly Glu Lys Ser 
945                 950             


<210> 20
<211> 901
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
        35                  40                  45              


Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr 
65                  70                  75                  80  


Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile 
                85                  90                  95      


Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr 
        115                 120                 125             


Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            180                 185                 190         


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        275                 280                 285             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    290                 295                 300                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
305                 310                 315                 320 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                325                 330                 335     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            340                 345                 350         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        355                 360                 365             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
    370                 375                 380                 


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
385                 390                 395                 400 


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
                405                 410                 415     


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
            420                 425                 430         


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
        435                 440                 445             


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
    450                 455                 460                 


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
465                 470                 475                 480 


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
                485                 490                 495     


Pro Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser 
            500                 505                 510         


Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
        515                 520                 525             


Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    530                 535                 540                 


Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu 
545                 550                 555                 560 


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
                565                 570                 575     


Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp 
            580                 585                 590         


Ser Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        595                 600                 605             


Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu 
    610                 615                 620                 


Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr 
625                 630                 635                 640 


Ile Thr Cys Gln Ala Ser His Asp Ile Arg Asn Tyr Leu Asn Trp Tyr 
                645                 650                 655     


Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser 
            660                 665                 670         


Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly 
        675                 680                 685             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    690                 695                 700                 


Thr Tyr Tyr Cys Gln Gln Tyr Asp Gly Leu Pro Leu Thr Phe Gly Gln 
705                 710                 715                 720 


Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
                725                 730                 735     


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
            740                 745                 750         


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
        755                 760                 765             


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
    770                 775                 780                 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
785                 790                 795                 800 


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
                805                 810                 815     


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
            820                 825                 830         


Glu Cys Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn 
        835                 840                 845             


Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr 
    850                 855                 860                 


Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr 
865                 870                 875                 880 


Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys 
                885                 890                 895     


Asn Gly Glu Lys Ser 
            900     


<210> 21
<211> 900
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
145                 150                 155                 160 


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
                165                 170                 175     


Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr 
        195                 200                 205             


Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile 
    210                 215                 220                 


Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala 
225                 230                 235                 240 


Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr 
                245                 250                 255     


Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        275                 280                 285             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    290                 295                 300                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
305                 310                 315                 320 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                325                 330                 335     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            340                 345                 350         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        355                 360                 365             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
    370                 375                 380                 


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
385                 390                 395                 400 


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
                405                 410                 415     


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
            420                 425                 430         


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
        435                 440                 445             


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
    450                 455                 460                 


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
465                 470                 475                 480 


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
                485                 490                 495     


Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
            500                 505                 510         


Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His 
        515                 520                 525             


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    530                 535                 540                 


Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro 
545                 550                 555                 560 


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                565                 570                 575     


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            580                 585                 590         


Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
        595                 600                 605             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro Val Leu Thr 
    610                 615                 620                 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Arg Ile Thr 
625                 630                 635                 640 


Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln 
                645                 650                 655     


Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg 
            660                 665                 670         


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
        675                 680                 685             


Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr 
    690                 695                 700                 


Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Tyr Val Val Phe Gly Gly 
705                 710                 715                 720 


Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val 
                725                 730                 735     


Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr 
            740                 745                 750         


Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala 
        755                 760                 765             


Trp Lys Ala Asp Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys 
    770                 775                 780                 


Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser 
785                 790                 795                 800 


Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val 
                805                 810                 815     


Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys 
            820                 825                 830         


Ser Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys 
        835                 840                 845             


Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser 
    850                 855                 860                 


Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe 
865                 870                 875                 880 


Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn 
                885                 890                 895     


Gly Glu Lys Ser 
            900 


<210> 22
<211> 654
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
        35                  40                  45              


Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr 
65                  70                  75                  80  


Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile 
                85                  90                  95      


Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr 
        115                 120                 125             


Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
145                 150                 155                 160 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                165                 170                 175     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            180                 185                 190         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        195                 200                 205             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    210                 215                 220                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
225                 230                 235                 240 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                245                 250                 255     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            260                 265                 270         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        275                 280                 285             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    290                 295                 300                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
305                 310                 315                 320 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                325                 330                 335     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            340                 345                 350         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        355                 360                 365             


Pro Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser 
    370                 375                 380                 


Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
385                 390                 395                 400 


Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                405                 410                 415     


Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu 
            420                 425                 430         


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
        435                 440                 445             


Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp 
    450                 455                 460                 


Ser Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
465                 470                 475                 480 


Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser 
                485                 490                 495     


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
            500                 505                 510         


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser 
        515                 520                 525             


Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn 
    530                 535                 540                 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
545                 550                 555                 560 


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
                565                 570                 575     


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp 
            580                 585                 590         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        595                 600                 605             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    610                 615                 620                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
625                 630                 635                 640 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                645                 650                 


<210> 23
<211> 1328
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1205                 1210                 1215             


Ala Ala  Ala Ile Glu Val Met  Tyr Pro Pro Pro Tyr  Leu Asp Asn 
    1220                 1225                 1230             


Glu Lys  Ser Asn Gly Thr Ile  Ile His Val Lys Gly  Lys His Leu 
    1235                 1240                 1245             


Cys Pro  Ser Pro Leu Phe Pro  Gly Pro Ser Lys Pro  Phe Trp Val 
    1250                 1255                 1260             


Leu Val  Val Val Gly Gly Val  Leu Ala Cys Tyr Ser  Leu Leu Val 
    1265                 1270                 1275             


Thr Val  Ala Phe Ile Ile Phe  Trp Val Arg Ser Lys  Arg Ser Arg 
    1280                 1285                 1290             


Leu Leu  His Ser Asp Tyr Met  Asn Met Thr Pro Arg  Arg Pro Gly 
    1295                 1300                 1305             


Pro Thr  Arg Lys His Tyr Gln  Pro Tyr Ala Pro Pro  Arg Asp Phe 
    1310                 1315                 1320             


Ala Ala  Tyr Arg Ser 
    1325             


<210> 24
<211> 1183
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
        275                 280                 285             


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
                325                 330                 335     


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
            340                 345                 350         


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Tyr 
        355                 360                 365             


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
385                 390                 395                 400 


Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
                405                 410                 415     


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
            420                 425                 430         


Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
        435                 440                 445             


Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro 
    450                 455                 460                 


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
465                 470                 475                 480 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
                485                 490                 495     


Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg 
            500                 505                 510         


Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val 
        515                 520                 525             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro 
    530                 535                 540                 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
545                 550                 555                 560 


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln 
                565                 570                 575     


Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn 
            580                 585                 590         


Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 
        595                 600                 605             


Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
    610                 615                 620                 


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly 
625                 630                 635                 640 


Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val Thr Val 
                645                 650                 655     


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
            660                 665                 670         


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
        675                 680                 685             


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
    690                 695                 700                 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
705                 710                 715                 720 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
                725                 730                 735     


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
            740                 745                 750         


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
        755                 760                 765             


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
    770                 775                 780                 


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
785                 790                 795                 800 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
                805                 810                 815     


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
            820                 825                 830         


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
        835                 840                 845             


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
    850                 855                 860                 


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
865                 870                 875                 880 


Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro 
                885                 890                 895     


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
            900                 905                 910         


Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile 
        915                 920                 925             


Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly 
    930                 935                 940                 


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala 
945                 950                 955                 960 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro 
                965                 970                 975     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            980                 985                 990         


Pro Ser Val Phe Ile Phe Pro Pro  Ser Asp Glu Gln Leu  Lys Ser Gly 
        995                 1000                 1005             


Thr Ala  Ser Val Val Cys Leu  Leu Asn Asn Phe Tyr  Pro Arg Glu 
    1010                 1015                 1020             


Ala Lys  Val Gln Trp Lys Val  Asp Asn Ala Leu Gln  Ser Gly Asn 
    1025                 1030                 1035             


Ser Gln  Glu Ser Val Thr Glu  Gln Asp Ser Lys Asp  Ser Thr Tyr 
    1040                 1045                 1050             


Ser Leu  Ser Ser Thr Leu Thr  Leu Ser Lys Ala Asp  Tyr Glu Lys 
    1055                 1060                 1065             


His Lys  Val Tyr Ala Cys Glu  Val Thr His Gln Gly  Leu Ser Ser 
    1070                 1075                 1080             


Pro Val  Thr Lys Ser Phe Asn  Arg Gly Glu Cys Pro  Ile Lys Thr 
    1085                 1090                 1095             


Asp Val  Ile Thr Met Asp Pro  Lys Asp Asn Cys Ser  Lys Asp Ala 
    1100                 1105                 1110             


Asn Asp  Thr Leu Leu Leu Gln  Leu Thr Asn Thr Ser  Ala Tyr Tyr 
    1115                 1120                 1125             


Met Tyr  Leu Leu Leu Leu Leu  Lys Ser Val Val Tyr  Phe Ala Ile 
    1130                 1135                 1140             


Ile Thr  Cys Cys Leu Leu Arg  Arg Thr Ala Phe Cys  Cys Asn Gly 
    1145                 1150                 1155             


Glu Lys  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1160                 1165                 1170             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys 
    1175                 1180             


<210> 25
<211> 1193
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu 
        275                 280                 285             


Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
    290                 295                 300                 


Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg 
305                 310                 315                 320 


Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser 
                325                 330                 335     


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
            340                 345                 350         


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
        355                 360                 365             


Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr 
    370                 375                 380                 


Phe Asn Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
385                 390                 395                 400 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr Asp His Val Lys 
            500                 505                 510         


Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys 
        515                 520                 525             


Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr 
    530                 535                 540                 


Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe 
545                 550                 555                 560 


Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys Arg Ser Gly Ser 
                565                 570                 575     


Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
            580                 585                 590         


Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu 
        595                 600                 605             


Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr Gly Leu Pro Val 
    610                 615                 620                 


Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Arg 
625                 630                 635                 640 


Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr 
                645                 650                 655     


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser 
            660                 665                 670         


Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly 
        675                 680                 685             


Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala 
    690                 695                 700                 


Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Tyr Val Val Phe 
705                 710                 715                 720 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Arg Gly Gly Gly Gly 
                725                 730                 735     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Met Ala Glu 
            740                 745                 750         


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 
        755                 760                 765             


Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp 
    770                 775                 780                 


Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 
785                 790                 795                 800 


Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
                805                 810                 815     


Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 
            820                 825                 830         


Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 
        835                 840                 845             


Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn Trp 
    850                 855                 860                 


Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
865                 870                 875                 880 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser 
                885                 890                 895     


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
            900                 905                 910         


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
        915                 920                 925             


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
    930                 935                 940                 


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
945                 950                 955                 960 


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
                965                 970                 975     


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
            980                 985                 990         


Lys Leu Glu Ile Lys Arg Thr Val  Ala Ala Pro Ser Val  Phe Ile Phe 
        995                 1000                 1005             


Pro Pro  Ser Asp Glu Gln Leu  Lys Ser Gly Thr Ala  Ser Val Val 
    1010                 1015                 1020             


Cys Leu  Leu Asn Asn Phe Tyr  Pro Arg Glu Ala Lys  Val Gln Trp 
    1025                 1030                 1035             


Lys Val  Asp Asn Ala Leu Gln  Ser Gly Asn Ser Gln  Glu Ser Val 
    1040                 1045                 1050             


Thr Glu  Gln Asp Ser Lys Asp  Ser Thr Tyr Ser Leu  Ser Ser Thr 
    1055                 1060                 1065             


Leu Thr  Leu Ser Lys Ala Asp  Tyr Glu Lys His Lys  Val Tyr Ala 
    1070                 1075                 1080             


Cys Glu  Val Thr His Gln Gly  Leu Ser Ser Pro Val  Thr Lys Ser 
    1085                 1090                 1095             


Phe Asn  Arg Gly Glu Cys Pro  Ile Lys Thr Asp Val  Ile Thr Met 
    1100                 1105                 1110             


Asp Pro  Lys Asp Asn Cys Ser  Lys Asp Ala Asn Asp  Thr Leu Leu 
    1115                 1120                 1125             


Leu Gln  Leu Thr Asn Thr Ser  Ala Tyr Tyr Met Tyr  Leu Leu Leu 
    1130                 1135                 1140             


Leu Leu  Lys Ser Val Val Tyr  Phe Ala Ile Ile Thr  Cys Cys Leu 
    1145                 1150                 1155             


Leu Arg  Arg Thr Ala Phe Cys  Cys Asn Gly Glu Lys  Ser Asp Tyr 
    1160                 1165                 1170             


Lys Asp  His Asp Gly Asp Tyr  Lys Asp His Asp Ile  Asp Tyr Lys 
    1175                 1180                 1185             


Asp Asp  Asp Asp Lys 
    1190             


<210> 26
<211> 1203
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        275                 280                 285             


Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys 
    290                 295                 300                 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys 
305                 310                 315                 320 


Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly 
                325                 330                 335     


Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu 
            340                 345                 350         


Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        355                 360                 365             


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr 
    370                 375                 380                 


Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val Thr 
385                 390                 395                 400 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                405                 410                 415     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            420                 425                 430         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        435                 440                 445             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    450                 455                 460                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
465                 470                 475                 480 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                485                 490                 495     


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser 
            500                 505                 510         


Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser 
        515                 520                 525             


Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn 
    530                 535                 540                 


Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr 
545                 550                 555                 560 


Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala 
                565                 570                 575     


Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp 
            580                 585                 590         


Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu 
        595                 600                 605             


Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser 
    610                 615                 620                 


Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro 
625                 630                 635                 640 


Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys 
                645                 650                 655     


Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val 
            660                 665                 670         


Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
        675                 680                 685             


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu 
    690                 695                 700                 


Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser 
705                 710                 715                 720 


Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser 
                725                 730                 735     


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
        755                 760                 765             


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
    770                 775                 780                 


Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
785                 790                 795                 800 


Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr 
                805                 810                 815     


Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile 
            820                 825                 830         


Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala 
        835                 840                 845             


Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr 
    850                 855                 860                 


Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr 
865                 870                 875                 880 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                885                 890                 895     


Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu 
            900                 905                 910         


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
        915                 920                 925             


Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro 
    930                 935                 940                 


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val 
945                 950                 955                 960 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                965                 970                 975     


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr 
            980                 985                 990         


Ser Asn Pro Pro Thr Phe Gly Gly  Gly Thr Lys Leu Glu  Ile Lys Arg 
        995                 1000                 1005             


Thr Val  Ala Ala Pro Ser Val  Phe Ile Phe Pro Pro  Ser Asp Glu 
    1010                 1015                 1020             


Gln Leu  Lys Ser Gly Thr Ala  Ser Val Val Cys Leu  Leu Asn Asn 
    1025                 1030                 1035             


Phe Tyr  Pro Arg Glu Ala Lys  Val Gln Trp Lys Val  Asp Asn Ala 
    1040                 1045                 1050             


Leu Gln  Ser Gly Asn Ser Gln  Glu Ser Val Thr Glu  Gln Asp Ser 
    1055                 1060                 1065             


Lys Asp  Ser Thr Tyr Ser Leu  Ser Ser Thr Leu Thr  Leu Ser Lys 
    1070                 1075                 1080             


Ala Asp  Tyr Glu Lys His Lys  Val Tyr Ala Cys Glu  Val Thr His 
    1085                 1090                 1095             


Gln Gly  Leu Ser Ser Pro Val  Thr Lys Ser Phe Asn  Arg Gly Glu 
    1100                 1105                 1110             


Cys Pro  Ile Lys Thr Asp Val  Ile Thr Met Asp Pro  Lys Asp Asn 
    1115                 1120                 1125             


Cys Ser  Lys Asp Ala Asn Asp  Thr Leu Leu Leu Gln  Leu Thr Asn 
    1130                 1135                 1140             


Thr Ser  Ala Tyr Tyr Met Tyr  Leu Leu Leu Leu Leu  Lys Ser Val 
    1145                 1150                 1155             


Val Tyr  Phe Ala Ile Ile Thr  Cys Cys Leu Leu Arg  Arg Thr Ala 
    1160                 1165                 1170             


Phe Cys  Cys Asn Gly Glu Lys  Ser Asp Tyr Lys Asp  His Asp Gly 
    1175                 1180                 1185             


Asp Tyr  Lys Asp His Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys 
    1190                 1195                 1200             


<210> 27
<211> 1176
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
        275                 280                 285             


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
    290                 295                 300                 


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
305                 310                 315                 320 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
                325                 330                 335     


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
            340                 345                 350         


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
    370                 375                 380                 


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
                405                 410                 415     


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
            420                 425                 430         


Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
        435                 440                 445             


Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser 
    450                 455                 460                 


Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
465                 470                 475                 480 


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
                485                 490                 495     


Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro 
            500                 505                 510         


Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    530                 535                 540                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
545                 550                 555                 560 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                565                 570                 575     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            580                 585                 590         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        595                 600                 605             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    610                 615                 620                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr 
625                 630                 635                 640 


Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln 
                645                 650                 655     


Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys 
            660                 665                 670         


Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala 
        675                 680                 685             


Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu 
    690                 695                 700                 


Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn 
705                 710                 715                 720 


Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
                725                 730                 735     


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
            740                 745                 750         


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
        755                 760                 765             


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
    770                 775                 780                 


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
785                 790                 795                 800 


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
                805                 810                 815     


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
            820                 825                 830         


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
        835                 840                 845             


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
    850                 855                 860                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro Val Leu Thr Gln Pro 
865                 870                 875                 880 


Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly 
                885                 890                 895     


Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro 
            900                 905                 910         


Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser 
        915                 920                 925             


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
    930                 935                 940                 


Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys 
945                 950                 955                 960 


Gln Val Trp Asp Ser Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr 
                965                 970                 975     


Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu 
            980                 985                 990         


Phe Pro Pro Ser Ser Glu Glu Leu  Gln Ala Asn Lys Ala  Thr Leu Val 
        995                 1000                 1005             


Cys Leu  Ile Ser Asp Phe Tyr  Pro Gly Ala Val Thr  Val Ala Trp 
    1010                 1015                 1020             


Lys Ala  Asp Gly Ser Pro Val  Lys Ala Gly Val Glu  Thr Thr Lys 
    1025                 1030                 1035             


Pro Ser  Lys Gln Ser Asn Asn  Lys Tyr Ala Ala Ser  Ser Tyr Leu 
    1040                 1045                 1050             


Ser Leu  Thr Pro Glu Gln Trp  Lys Ser His Arg Ser  Tyr Ser Cys 
    1055                 1060                 1065             


Gln Val  Thr His Glu Gly Ser  Thr Val Glu Lys Thr  Val Ala Pro 
    1070                 1075                 1080             


Thr Glu  Cys Ser Pro Ile Lys  Thr Asp Val Ile Thr  Met Asp Pro 
    1085                 1090                 1095             


Lys Asp  Asn Cys Ser Lys Asp  Ala Asn Asp Thr Leu  Leu Leu Gln 
    1100                 1105                 1110             


Leu Thr  Asn Thr Ser Ala Tyr  Tyr Met Tyr Leu Leu  Leu Leu Leu 
    1115                 1120                 1125             


Lys Ser  Val Val Tyr Phe Ala  Ile Ile Thr Cys Cys  Leu Leu Arg 
    1130                 1135                 1140             


Arg Thr  Ala Phe Cys Cys Asn  Gly Glu Lys Ser Asp  Tyr Lys Asp 
    1145                 1150                 1155             


His Asp  Gly Asp Tyr Lys Asp  His Asp Ile Asp Tyr  Lys Asp Asp 
    1160                 1165                 1170             


Asp Asp  Lys 
    1175     


<210> 28
<211> 666
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe 
        115                 120                 125             


Asn Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro 
                245                 250                 255     


Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro 
            260                 265                 270         


Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val 
        275                 280                 285             


Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu 
    290                 295                 300                 


Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys Arg Ser Gly Ser Gly 
305                 310                 315                 320 


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
                325                 330                 335     


Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu 
            340                 345                 350         


Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr Gly Gln Ile Val Leu 
        355                 360                 365             


Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr 
    370                 375                 380                 


Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln 
385                 390                 395                 400 


Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn 
                405                 410                 415     


Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            420                 425                 430         


Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr 
        435                 440                 445             


Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly 
    450                 455                 460                 


Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
465                 470                 475                 480 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                485                 490                 495     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            500                 505                 510         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        515                 520                 525             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    530                 535                 540                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
545                 550                 555                 560 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                565                 570                 575     


Cys Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys 
            580                 585                 590         


Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser 
        595                 600                 605             


Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe 
    610                 615                 620                 


Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn 
625                 630                 635                 640 


Gly Glu Lys Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His 
                645                 650                 655     


Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
            660                 665     


<210> 29
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Ala Ala  Ala Ile Glu Val Met  Tyr Pro Pro 
    1205                 1210                 1215             


Pro Tyr  Leu Asp Asn Glu Lys  Ser Asn Gly Thr Ile  Ile His Val 
    1220                 1225                 1230             


Lys Gly  Lys His Leu Cys Pro  Ser Pro Leu Phe Pro  Gly Pro Ser 
    1235                 1240                 1245             


Lys Pro  Phe Trp Val Leu Val  Val Val Gly Gly Val  Leu Ala Cys 
    1250                 1255                 1260             


Tyr Ser  Leu Leu Val Thr Val  Ala Phe Ile Ile Phe  Trp Val Arg 
    1265                 1270                 1275             


Ser Lys  Arg Ser Arg Leu Leu  His Ser Asp Tyr Met  Asn Met Thr 
    1280                 1285                 1290             


Pro Arg  Arg Pro Gly Pro Thr  Arg Lys His Tyr Gln  Pro Tyr Ala 
    1295                 1300                 1305             


Pro Pro  Arg Asp Phe Ala Ala  Tyr Arg Ser 
    1310                 1315             


<210> 30
<211> 1317
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1205                 1210                 1215             


Ala Ala  Ala Thr Gly Pro Ala  Asp Leu Ser Pro Gly  Ala Ser Ser 
    1220                 1225                 1230             


Val Thr  Pro Pro Ala Pro Ala  Arg Glu Pro Gly His  Ser Pro Gln 
    1235                 1240                 1245             


Ile Ile  Ser Phe Phe Leu Ala  Leu Thr Ser Thr Ala  Leu Leu Phe 
    1250                 1255                 1260             


Leu Leu  Phe Phe Leu Thr Leu  Arg Phe Ser Val Val  Lys Arg Gly 
    1265                 1270                 1275             


Arg Lys  Lys Leu Leu Tyr Ile  Phe Lys Gln Pro Phe  Met Arg Pro 
    1280                 1285                 1290             


Val Gln  Thr Thr Gln Glu Glu  Asp Gly Cys Ser Cys  Arg Phe Pro 
    1295                 1300                 1305             


Glu Glu  Glu Glu Gly Gly Cys  Glu Leu 
    1310                 1315         


<210> 31
<211> 1307
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Ala Ala  Ala Thr Gly Pro Ala  Asp Leu Ser 
    1205                 1210                 1215             


Pro Gly  Ala Ser Ser Val Thr  Pro Pro Ala Pro Ala  Arg Glu Pro 
    1220                 1225                 1230             


Gly His  Ser Pro Gln Ile Ile  Ser Phe Phe Leu Ala  Leu Thr Ser 
    1235                 1240                 1245             


Thr Ala  Leu Leu Phe Leu Leu  Phe Phe Leu Thr Leu  Arg Phe Ser 
    1250                 1255                 1260             


Val Val  Lys Arg Gly Arg Lys  Lys Leu Leu Tyr Ile  Phe Lys Gln 
    1265                 1270                 1275             


Pro Phe  Met Arg Pro Val Gln  Thr Thr Gln Glu Glu  Asp Gly Cys 
    1280                 1285                 1290             


Ser Cys  Arg Phe Pro Glu Glu  Glu Glu Gly Gly Cys  Glu Leu 
    1295                 1300                 1305         


<210> 32
<211> 1342
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1205                 1210                 1215             


Ala Ala  Ala Thr Gly Pro Thr  His Leu Pro Tyr Val  Ser Glu Met 
    1220                 1225                 1230             


Leu Glu  Ala Arg Thr Ala Gly  His Met Gln Thr Leu  Ala Asp Phe 
    1235                 1240                 1245             


Arg Gln  Leu Pro Ala Arg Thr  Leu Ser Thr His Trp  Pro Pro Gln 
    1250                 1255                 1260             


Arg Ser  Leu Cys Ser Ser Asp  Phe Ile Arg Ile Leu  Val Ile Phe 
    1265                 1270                 1275             


Ser Gly  Met Phe Leu Val Phe  Thr Leu Ala Gly Ala  Leu Phe Leu 
    1280                 1285                 1290             


His Gln  Arg Arg Lys Tyr Arg  Ser Asn Lys Gly Glu  Ser Pro Val 
    1295                 1300                 1305             


Glu Pro  Ala Glu Pro Cys Arg  Tyr Ser Cys Pro Arg  Glu Glu Glu 
    1310                 1315                 1320             


Gly Ser  Thr Ile Pro Ile Gln  Glu Asp Tyr Arg Lys  Pro Glu Pro 
    1325                 1330                 1335             


Ala Cys  Ser Pro 
    1340         


<210> 33
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Ala Ala  Ala Thr Gly Pro Thr  His Leu Pro 
    1205                 1210                 1215             


Tyr Val  Ser Glu Met Leu Glu  Ala Arg Thr Ala Gly  His Met Gln 
    1220                 1225                 1230             


Thr Leu  Ala Asp Phe Arg Gln  Leu Pro Ala Arg Thr  Leu Ser Thr 
    1235                 1240                 1245             


His Trp  Pro Pro Gln Arg Ser  Leu Cys Ser Ser Asp  Phe Ile Arg 
    1250                 1255                 1260             


Ile Leu  Val Ile Phe Ser Gly  Met Phe Leu Val Phe  Thr Leu Ala 
    1265                 1270                 1275             


Gly Ala  Leu Phe Leu His Gln  Arg Arg Lys Tyr Arg  Ser Asn Lys 
    1280                 1285                 1290             


Gly Glu  Ser Pro Val Glu Pro  Ala Glu Pro Cys Arg  Tyr Ser Cys 
    1295                 1300                 1305             


Pro Arg  Glu Glu Glu Gly Ser  Thr Ile Pro Ile Gln  Glu Asp Tyr 
    1310                 1315                 1320             


Arg Lys  Pro Glu Pro Ala Cys  Ser Pro 
    1325                 1330         


<210> 34
<211> 1493
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1205                 1210                 1215             


Ala Ala  Ala Thr Gly Ala Pro  Pro Leu Gly Thr Gln  Pro Asp Cys 
    1220                 1225                 1230             


Asn Pro  Thr Pro Glu Asn Gly  Glu Ala Pro Ala Ser  Thr Ser Pro 
    1235                 1240                 1245             


Thr Gln  Ser Leu Leu Val Asp  Ser Gln Ala Ser Lys  Thr Leu Pro 
    1250                 1255                 1260             


Ile Pro  Thr Ser Ala Pro Val  Ala Leu Ser Ser Thr  Gly Lys Pro 
    1265                 1270                 1275             


Val Leu  Asp Ala Gly Pro Val  Leu Phe Trp Val Ile  Leu Val Leu 
    1280                 1285                 1290             


Val Val  Val Val Gly Ser Ser  Ala Phe Leu Leu Cys  His Arg Arg 
    1295                 1300                 1305             


Ala Cys  Arg Lys Arg Ile Arg  Gln Lys Leu His Leu  Cys Tyr Pro 
    1310                 1315                 1320             


Val Gln  Thr Ser Gln Pro Lys  Leu Glu Leu Val Asp  Ser Arg Pro 
    1325                 1330                 1335             


Arg Arg  Ser Ser Thr Gln Leu  Arg Ser Gly Ala Ser  Val Thr Glu 
    1340                 1345                 1350             


Pro Val  Ala Glu Glu Arg Gly  Leu Met Ser Gln Pro  Leu Met Glu 
    1355                 1360                 1365             


Thr Cys  His Ser Val Gly Ala  Ala Tyr Leu Glu Ser  Leu Pro Leu 
    1370                 1375                 1380             


Gln Asp  Ala Ser Pro Ala Gly  Gly Pro Ser Ser Pro  Arg Asp Leu 
    1385                 1390                 1395             


Pro Glu  Pro Arg Val Ser Thr  Glu His Thr Asn Asn  Lys Ile Glu 
    1400                 1405                 1410             


Lys Ile  Tyr Ile Met Lys Ala  Asp Thr Val Ile Val  Gly Thr Val 
    1415                 1420                 1425             


Lys Ala  Glu Leu Pro Glu Gly  Arg Gly Leu Ala Gly  Pro Ala Glu 
    1430                 1435                 1440             


Pro Glu  Leu Glu Glu Glu Leu  Glu Ala Asp His Thr  Pro His Tyr 
    1445                 1450                 1455             


Pro Glu  Gln Glu Thr Glu Pro  Pro Leu Gly Ser Cys  Ser Asp Val 
    1460                 1465                 1470             


Met Leu  Ser Val Glu Glu Glu  Gly Lys Glu Asp Pro  Leu Pro Thr 
    1475                 1480                 1485             


Ala Ala  Ser Gly Lys 
    1490             


<210> 35
<211> 1483
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Ala Ala  Ala Thr Gly Ala Pro  Pro Leu Gly 
    1205                 1210                 1215             


Thr Gln  Pro Asp Cys Asn Pro  Thr Pro Glu Asn Gly  Glu Ala Pro 
    1220                 1225                 1230             


Ala Ser  Thr Ser Pro Thr Gln  Ser Leu Leu Val Asp  Ser Gln Ala 
    1235                 1240                 1245             


Ser Lys  Thr Leu Pro Ile Pro  Thr Ser Ala Pro Val  Ala Leu Ser 
    1250                 1255                 1260             


Ser Thr  Gly Lys Pro Val Leu  Asp Ala Gly Pro Val  Leu Phe Trp 
    1265                 1270                 1275             


Val Ile  Leu Val Leu Val Val  Val Val Gly Ser Ser  Ala Phe Leu 
    1280                 1285                 1290             


Leu Cys  His Arg Arg Ala Cys  Arg Lys Arg Ile Arg  Gln Lys Leu 
    1295                 1300                 1305             


His Leu  Cys Tyr Pro Val Gln  Thr Ser Gln Pro Lys  Leu Glu Leu 
    1310                 1315                 1320             


Val Asp  Ser Arg Pro Arg Arg  Ser Ser Thr Gln Leu  Arg Ser Gly 
    1325                 1330                 1335             


Ala Ser  Val Thr Glu Pro Val  Ala Glu Glu Arg Gly  Leu Met Ser 
    1340                 1345                 1350             


Gln Pro  Leu Met Glu Thr Cys  His Ser Val Gly Ala  Ala Tyr Leu 
    1355                 1360                 1365             


Glu Ser  Leu Pro Leu Gln Asp  Ala Ser Pro Ala Gly  Gly Pro Ser 
    1370                 1375                 1380             


Ser Pro  Arg Asp Leu Pro Glu  Pro Arg Val Ser Thr  Glu His Thr 
    1385                 1390                 1395             


Asn Asn  Lys Ile Glu Lys Ile  Tyr Ile Met Lys Ala  Asp Thr Val 
    1400                 1405                 1410             


Ile Val  Gly Thr Val Lys Ala  Glu Leu Pro Glu Gly  Arg Gly Leu 
    1415                 1420                 1425             


Ala Gly  Pro Ala Glu Pro Glu  Leu Glu Glu Glu Leu  Glu Ala Asp 
    1430                 1435                 1440             


His Thr  Pro His Tyr Pro Glu  Gln Glu Thr Glu Pro  Pro Leu Gly 
    1445                 1450                 1455             


Ser Cys  Ser Asp Val Met Leu  Ser Val Glu Glu Glu  Gly Lys Glu 
    1460                 1465                 1470             


Asp Pro  Leu Pro Thr Ala Ala  Ser Gly Lys 
    1475                 1480             


<210> 36
<211> 1333
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1205                 1210                 1215             


Ala Ala  Ala Thr Gly Asp Arg  Asp Pro Pro Ala Thr  Gln Pro Gln 
    1220                 1225                 1230             


Glu Thr  Gln Gly Pro Pro Ala  Arg Pro Ile Thr Val  Gln Pro Thr 
    1235                 1240                 1245             


Glu Ala  Trp Pro Arg Thr Ser  Gln Gly Pro Ser Thr  Arg Pro Val 
    1250                 1255                 1260             


Glu Val  Pro Gly Gly Arg Ala  Val Ala Ala Ile Leu  Gly Leu Gly 
    1265                 1270                 1275             


Leu Val  Leu Gly Leu Leu Gly  Pro Leu Ala Ile Leu  Leu Ala Leu 
    1280                 1285                 1290             


Tyr Leu  Leu Arg Arg Asp Gln  Arg Leu Pro Pro Asp  Ala His Lys 
    1295                 1300                 1305             


Pro Pro  Gly Gly Gly Ser Phe  Arg Thr Pro Ile Gln  Glu Glu Gln 
    1310                 1315                 1320             


Ala Asp  Ala His Ser Thr Leu  Ala Lys Ile 
    1325                 1330             


<210> 37
<211> 1323
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Ala Ala  Ala Thr Gly Asp Arg  Asp Pro Pro 
    1205                 1210                 1215             


Ala Thr  Gln Pro Gln Glu Thr  Gln Gly Pro Pro Ala  Arg Pro Ile 
    1220                 1225                 1230             


Thr Val  Gln Pro Thr Glu Ala  Trp Pro Arg Thr Ser  Gln Gly Pro 
    1235                 1240                 1245             


Ser Thr  Arg Pro Val Glu Val  Pro Gly Gly Arg Ala  Val Ala Ala 
    1250                 1255                 1260             


Ile Leu  Gly Leu Gly Leu Val  Leu Gly Leu Leu Gly  Pro Leu Ala 
    1265                 1270                 1275             


Ile Leu  Leu Ala Leu Tyr Leu  Leu Arg Arg Asp Gln  Arg Leu Pro 
    1280                 1285                 1290             


Pro Asp  Ala His Lys Pro Pro  Gly Gly Gly Ser Phe  Arg Thr Pro 
    1295                 1300                 1305             


Ile Gln  Glu Glu Gln Ala Asp  Ala His Ser Thr Leu  Ala Lys Ile 
    1310                 1315                 1320             


<210> 38
<211> 1340
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1205                 1210                 1215             


Ala Ala  Ala Thr Gly Thr Thr  Thr Pro Ala Pro Arg  Pro Pro Thr 
    1220                 1225                 1230             


Pro Ala  Pro Thr Ile Ala Ser  Gln Pro Leu Ser Leu  Arg Pro Glu 
    1235                 1240                 1245             


Ala Cys  Arg Pro Ala Ala Gly  Gly Ala Val His Thr  Arg Gly Leu 
    1250                 1255                 1260             


Asp Phe  Ala Cys Asp Ile Tyr  Ile Trp Ala Pro Leu  Ala Gly Thr 
    1265                 1270                 1275             


Cys Gly  Val Leu Leu Leu Ser  Leu Val Ile Thr Leu  Tyr Cys Gln 
    1280                 1285                 1290             


Arg Arg  Lys Tyr Arg Ser Asn  Lys Gly Glu Ser Pro  Val Glu Pro 
    1295                 1300                 1305             


Ala Glu  Pro Cys Arg Tyr Ser  Cys Pro Arg Glu Glu  Glu Gly Ser 
    1310                 1315                 1320             


Thr Ile  Pro Ile Gln Glu Asp  Tyr Arg Lys Pro Glu  Pro Ala Cys 
    1325                 1330                 1335             


Ser Pro  
    1340 


<210> 39
<211> 1330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Ala Ala  Ala Thr Gly Thr Thr  Thr Pro Ala 
    1205                 1210                 1215             


Pro Arg  Pro Pro Thr Pro Ala  Pro Thr Ile Ala Ser  Gln Pro Leu 
    1220                 1225                 1230             


Ser Leu  Arg Pro Glu Ala Cys  Arg Pro Ala Ala Gly  Gly Ala Val 
    1235                 1240                 1245             


His Thr  Arg Gly Leu Asp Phe  Ala Cys Asp Ile Tyr  Ile Trp Ala 
    1250                 1255                 1260             


Pro Leu  Ala Gly Thr Cys Gly  Val Leu Leu Leu Ser  Leu Val Ile 
    1265                 1270                 1275             


Thr Leu  Tyr Cys Gln Arg Arg  Lys Tyr Arg Ser Asn  Lys Gly Glu 
    1280                 1285                 1290             


Ser Pro  Val Glu Pro Ala Glu  Pro Cys Arg Tyr Ser  Cys Pro Arg 
    1295                 1300                 1305             


Glu Glu  Glu Gly Ser Thr Ile  Pro Ile Gln Glu Asp  Tyr Arg Lys 
    1310                 1315                 1320             


Pro Glu  Pro Ala Cys Ser Pro  
    1325                 1330 


<210> 40
<211> 1480
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1205                 1210                 1215             


Ala Ala  Ala Thr Gly Thr Thr  Thr Pro Ala Pro Arg  Pro Pro Thr 
    1220                 1225                 1230             


Pro Ala  Pro Thr Ile Ala Ser  Gln Pro Leu Ser Leu  Arg Pro Glu 
    1235                 1240                 1245             


Ala Cys  Arg Pro Ala Ala Gly  Gly Ala Val His Thr  Arg Gly Leu 
    1250                 1255                 1260             


Asp Phe  Ala Cys Asp Ile Tyr  Ile Trp Ala Pro Leu  Ala Gly Thr 
    1265                 1270                 1275             


Cys Gly  Val Leu Leu Leu Ser  Leu Val Ile Thr Leu  Tyr Cys His 
    1280                 1285                 1290             


Arg Arg  Ala Cys Arg Lys Arg  Ile Arg Gln Lys Leu  His Leu Cys 
    1295                 1300                 1305             


Tyr Pro  Val Gln Thr Ser Gln  Pro Lys Leu Glu Leu  Val Asp Ser 
    1310                 1315                 1320             


Arg Pro  Arg Arg Ser Ser Thr  Gln Leu Arg Ser Gly  Ala Ser Val 
    1325                 1330                 1335             


Thr Glu  Pro Val Ala Glu Glu  Arg Gly Leu Met Ser  Gln Pro Leu 
    1340                 1345                 1350             


Met Glu  Thr Cys His Ser Val  Gly Ala Ala Tyr Leu  Glu Ser Leu 
    1355                 1360                 1365             


Pro Leu  Gln Asp Ala Ser Pro  Ala Gly Gly Pro Ser  Ser Pro Arg 
    1370                 1375                 1380             


Asp Leu  Pro Glu Pro Arg Val  Ser Thr Glu His Thr  Asn Asn Lys 
    1385                 1390                 1395             


Ile Glu  Lys Ile Tyr Ile Met  Lys Ala Asp Thr Val  Ile Val Gly 
    1400                 1405                 1410             


Thr Val  Lys Ala Glu Leu Pro  Glu Gly Arg Gly Leu  Ala Gly Pro 
    1415                 1420                 1425             


Ala Glu  Pro Glu Leu Glu Glu  Glu Leu Glu Ala Asp  His Thr Pro 
    1430                 1435                 1440             


His Tyr  Pro Glu Gln Glu Thr  Glu Pro Pro Leu Gly  Ser Cys Ser 
    1445                 1450                 1455             


Asp Val  Met Leu Ser Val Glu  Glu Glu Gly Lys Glu  Asp Pro Leu 
    1460                 1465                 1470             


Pro Thr  Ala Ala Ser Gly Lys  
    1475                 1480 


<210> 41
<211> 1470
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Ala Ala  Ala Thr Gly Thr Thr  Thr Pro Ala 
    1205                 1210                 1215             


Pro Arg  Pro Pro Thr Pro Ala  Pro Thr Ile Ala Ser  Gln Pro Leu 
    1220                 1225                 1230             


Ser Leu  Arg Pro Glu Ala Cys  Arg Pro Ala Ala Gly  Gly Ala Val 
    1235                 1240                 1245             


His Thr  Arg Gly Leu Asp Phe  Ala Cys Asp Ile Tyr  Ile Trp Ala 
    1250                 1255                 1260             


Pro Leu  Ala Gly Thr Cys Gly  Val Leu Leu Leu Ser  Leu Val Ile 
    1265                 1270                 1275             


Thr Leu  Tyr Cys His Arg Arg  Ala Cys Arg Lys Arg  Ile Arg Gln 
    1280                 1285                 1290             


Lys Leu  His Leu Cys Tyr Pro  Val Gln Thr Ser Gln  Pro Lys Leu 
    1295                 1300                 1305             


Glu Leu  Val Asp Ser Arg Pro  Arg Arg Ser Ser Thr  Gln Leu Arg 
    1310                 1315                 1320             


Ser Gly  Ala Ser Val Thr Glu  Pro Val Ala Glu Glu  Arg Gly Leu 
    1325                 1330                 1335             


Met Ser  Gln Pro Leu Met Glu  Thr Cys His Ser Val  Gly Ala Ala 
    1340                 1345                 1350             


Tyr Leu  Glu Ser Leu Pro Leu  Gln Asp Ala Ser Pro  Ala Gly Gly 
    1355                 1360                 1365             


Pro Ser  Ser Pro Arg Asp Leu  Pro Glu Pro Arg Val  Ser Thr Glu 
    1370                 1375                 1380             


His Thr  Asn Asn Lys Ile Glu  Lys Ile Tyr Ile Met  Lys Ala Asp 
    1385                 1390                 1395             


Thr Val  Ile Val Gly Thr Val  Lys Ala Glu Leu Pro  Glu Gly Arg 
    1400                 1405                 1410             


Gly Leu  Ala Gly Pro Ala Glu  Pro Glu Leu Glu Glu  Glu Leu Glu 
    1415                 1420                 1425             


Ala Asp  His Thr Pro His Tyr  Pro Glu Gln Glu Thr  Glu Pro Pro 
    1430                 1435                 1440             


Leu Gly  Ser Cys Ser Asp Val  Met Leu Ser Val Glu  Glu Glu Gly 
    1445                 1450                 1455             


Lys Glu  Asp Pro Leu Pro Thr  Ala Ala Ser Gly Lys  
    1460                 1465                 1470 


<210> 42
<211> 1334
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1205                 1210                 1215             


Ala Ala  Ala Thr Gly Thr Thr  Thr Pro Ala Pro Arg  Pro Pro Thr 
    1220                 1225                 1230             


Pro Ala  Pro Thr Ile Ala Ser  Gln Pro Leu Ser Leu  Arg Pro Glu 
    1235                 1240                 1245             


Ala Cys  Arg Pro Ala Ala Gly  Gly Ala Val His Thr  Arg Gly Leu 
    1250                 1255                 1260             


Asp Phe  Ala Cys Asp Ile Tyr  Ile Trp Ala Pro Leu  Ala Gly Thr 
    1265                 1270                 1275             


Cys Gly  Val Leu Leu Leu Ser  Leu Val Ile Thr Leu  Tyr Cys Ala 
    1280                 1285                 1290             


Leu Tyr  Leu Leu Arg Arg Asp  Gln Arg Leu Pro Pro  Asp Ala His 
    1295                 1300                 1305             


Lys Pro  Pro Gly Gly Gly Ser  Phe Arg Thr Pro Ile  Gln Glu Glu 
    1310                 1315                 1320             


Gln Ala  Asp Ala His Ser Thr  Leu Ala Lys Ile 
    1325                 1330                 


<210> 43
<211> 1324
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Ala Ala  Ala Thr Gly Thr Thr  Thr Pro Ala 
    1205                 1210                 1215             


Pro Arg  Pro Pro Thr Pro Ala  Pro Thr Ile Ala Ser  Gln Pro Leu 
    1220                 1225                 1230             


Ser Leu  Arg Pro Glu Ala Cys  Arg Pro Ala Ala Gly  Gly Ala Val 
    1235                 1240                 1245             


His Thr  Arg Gly Leu Asp Phe  Ala Cys Asp Ile Tyr  Ile Trp Ala 
    1250                 1255                 1260             


Pro Leu  Ala Gly Thr Cys Gly  Val Leu Leu Leu Ser  Leu Val Ile 
    1265                 1270                 1275             


Thr Leu  Tyr Cys Ala Leu Tyr  Leu Leu Arg Arg Asp  Gln Arg Leu 
    1280                 1285                 1290             


Pro Pro  Asp Ala His Lys Pro  Pro Gly Gly Gly Ser  Phe Arg Thr 
    1295                 1300                 1305             


Pro Ile  Gln Glu Glu Gln Ala  Asp Ala His Ser Thr  Leu Ala Lys 
    1310                 1315                 1320             


Ile 
    


<210> 44
<211> 1320
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Glu Gln Lys 
    1190                 1195                 1200             


Leu Ile  Ser Glu Glu Asp Leu  Ala Ala Ala Ile Glu  Val Met Tyr 
    1205                 1210                 1215             


Pro Pro  Pro Tyr Leu Asp Asn  Glu Lys Ser Asn Gly  Thr Ile Ile 
    1220                 1225                 1230             


His Val  Lys Gly Lys His Leu  Cys Pro Ser Pro Leu  Phe Pro Gly 
    1235                 1240                 1245             


Pro Ser  Lys Pro Phe Trp Val  Leu Val Val Val Gly  Gly Val Leu 
    1250                 1255                 1260             


Ala Cys  Tyr Ser Leu Leu Val  Thr Val Ala Phe Ile  Ile Phe Trp 
    1265                 1270                 1275             


Val Arg  Ser Lys Arg Ser Arg  Leu Leu His Ser Asp  Tyr Met Asn 
    1280                 1285                 1290             


Met Thr  Pro Arg Arg Pro Gly  Pro Thr Arg Lys His  Tyr Gln Pro 
    1295                 1300                 1305             


Tyr Ala  Pro Pro Arg Asp Phe  Ala Ala Tyr Arg Ser  
    1310                 1315                 1320 


<210> 45
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Ala Ala Ala 
    1190                 1195                 1200             


Ile Glu  Val Met Tyr Pro Pro  Pro Tyr Leu Asp Asn  Glu Lys Ser 
    1205                 1210                 1215             


Asn Gly  Thr Ile Ile His Val  Lys Gly Lys His Leu  Cys Pro Ser 
    1220                 1225                 1230             


Pro Leu  Phe Pro Gly Pro Ser  Lys Pro Phe Trp Val  Leu Val Val 
    1235                 1240                 1245             


Val Gly  Gly Val Leu Ala Cys  Tyr Ser Leu Leu Val  Thr Val Ala 
    1250                 1255                 1260             


Phe Ile  Ile Phe Trp Val Arg  Ser Lys Arg Ser Arg  Leu Leu His 
    1265                 1270                 1275             


Ser Asp  Tyr Met Asn Met Thr  Pro Arg Arg Pro Gly  Pro Thr Arg 
    1280                 1285                 1290             


Lys His  Tyr Gln Pro Tyr Ala  Pro Pro Arg Asp Phe  Ala Ala Tyr 
    1295                 1300                 1305             


Arg Ser  
    1310 


<210> 46
<211> 1309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Glu Gln Lys 
    1190                 1195                 1200             


Leu Ile  Ser Glu Glu Asp Leu  Ala Ala Ala Thr Gly  Pro Ala Asp 
    1205                 1210                 1215             


Leu Ser  Pro Gly Ala Ser Ser  Val Thr Pro Pro Ala  Pro Ala Arg 
    1220                 1225                 1230             


Glu Pro  Gly His Ser Pro Gln  Ile Ile Ser Phe Phe  Leu Ala Leu 
    1235                 1240                 1245             


Thr Ser  Thr Ala Leu Leu Phe  Leu Leu Phe Phe Leu  Thr Leu Arg 
    1250                 1255                 1260             


Phe Ser  Val Val Lys Arg Gly  Arg Lys Lys Leu Leu  Tyr Ile Phe 
    1265                 1270                 1275             


Lys Gln  Pro Phe Met Arg Pro  Val Gln Thr Thr Gln  Glu Glu Asp 
    1280                 1285                 1290             


Gly Cys  Ser Cys Arg Phe Pro  Glu Glu Glu Glu Gly  Gly Cys Glu 
    1295                 1300                 1305             


Leu 
    


<210> 47
<211> 1299
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Ala Ala Ala 
    1190                 1195                 1200             


Thr Gly  Pro Ala Asp Leu Ser  Pro Gly Ala Ser Ser  Val Thr Pro 
    1205                 1210                 1215             


Pro Ala  Pro Ala Arg Glu Pro  Gly His Ser Pro Gln  Ile Ile Ser 
    1220                 1225                 1230             


Phe Phe  Leu Ala Leu Thr Ser  Thr Ala Leu Leu Phe  Leu Leu Phe 
    1235                 1240                 1245             


Phe Leu  Thr Leu Arg Phe Ser  Val Val Lys Arg Gly  Arg Lys Lys 
    1250                 1255                 1260             


Leu Leu  Tyr Ile Phe Lys Gln  Pro Phe Met Arg Pro  Val Gln Thr 
    1265                 1270                 1275             


Thr Gln  Glu Glu Asp Gly Cys  Ser Cys Arg Phe Pro  Glu Glu Glu 
    1280                 1285                 1290             


Glu Gly  Gly Cys Glu Leu 
    1295                 


<210> 48
<211> 1334
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Glu Gln Lys 
    1190                 1195                 1200             


Leu Ile  Ser Glu Glu Asp Leu  Ala Ala Ala Thr Gly  Pro Thr His 
    1205                 1210                 1215             


Leu Pro  Tyr Val Ser Glu Met  Leu Glu Ala Arg Thr  Ala Gly His 
    1220                 1225                 1230             


Met Gln  Thr Leu Ala Asp Phe  Arg Gln Leu Pro Ala  Arg Thr Leu 
    1235                 1240                 1245             


Ser Thr  His Trp Pro Pro Gln  Arg Ser Leu Cys Ser  Ser Asp Phe 
    1250                 1255                 1260             


Ile Arg  Ile Leu Val Ile Phe  Ser Gly Met Phe Leu  Val Phe Thr 
    1265                 1270                 1275             


Leu Ala  Gly Ala Leu Phe Leu  His Gln Arg Arg Lys  Tyr Arg Ser 
    1280                 1285                 1290             


Asn Lys  Gly Glu Ser Pro Val  Glu Pro Ala Glu Pro  Cys Arg Tyr 
    1295                 1300                 1305             


Ser Cys  Pro Arg Glu Glu Glu  Gly Ser Thr Ile Pro  Ile Gln Glu 
    1310                 1315                 1320             


Asp Tyr  Arg Lys Pro Glu Pro  Ala Cys Ser Pro 
    1325                 1330                 


<210> 49
<211> 1324
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Ala Ala Ala 
    1190                 1195                 1200             


Thr Gly  Pro Thr His Leu Pro  Tyr Val Ser Glu Met  Leu Glu Ala 
    1205                 1210                 1215             


Arg Thr  Ala Gly His Met Gln  Thr Leu Ala Asp Phe  Arg Gln Leu 
    1220                 1225                 1230             


Pro Ala  Arg Thr Leu Ser Thr  His Trp Pro Pro Gln  Arg Ser Leu 
    1235                 1240                 1245             


Cys Ser  Ser Asp Phe Ile Arg  Ile Leu Val Ile Phe  Ser Gly Met 
    1250                 1255                 1260             


Phe Leu  Val Phe Thr Leu Ala  Gly Ala Leu Phe Leu  His Gln Arg 
    1265                 1270                 1275             


Arg Lys  Tyr Arg Ser Asn Lys  Gly Glu Ser Pro Val  Glu Pro Ala 
    1280                 1285                 1290             


Glu Pro  Cys Arg Tyr Ser Cys  Pro Arg Glu Glu Glu  Gly Ser Thr 
    1295                 1300                 1305             


Ile Pro  Ile Gln Glu Asp Tyr  Arg Lys Pro Glu Pro  Ala Cys Ser 
    1310                 1315                 1320             


Pro 
    


<210> 50
<211> 1485
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Glu Gln Lys 
    1190                 1195                 1200             


Leu Ile  Ser Glu Glu Asp Leu  Ala Ala Ala Thr Gly  Ala Pro Pro 
    1205                 1210                 1215             


Leu Gly  Thr Gln Pro Asp Cys  Asn Pro Thr Pro Glu  Asn Gly Glu 
    1220                 1225                 1230             


Ala Pro  Ala Ser Thr Ser Pro  Thr Gln Ser Leu Leu  Val Asp Ser 
    1235                 1240                 1245             


Gln Ala  Ser Lys Thr Leu Pro  Ile Pro Thr Ser Ala  Pro Val Ala 
    1250                 1255                 1260             


Leu Ser  Ser Thr Gly Lys Pro  Val Leu Asp Ala Gly  Pro Val Leu 
    1265                 1270                 1275             


Phe Trp  Val Ile Leu Val Leu  Val Val Val Val Gly  Ser Ser Ala 
    1280                 1285                 1290             


Phe Leu  Leu Cys His Arg Arg  Ala Cys Arg Lys Arg  Ile Arg Gln 
    1295                 1300                 1305             


Lys Leu  His Leu Cys Tyr Pro  Val Gln Thr Ser Gln  Pro Lys Leu 
    1310                 1315                 1320             


Glu Leu  Val Asp Ser Arg Pro  Arg Arg Ser Ser Thr  Gln Leu Arg 
    1325                 1330                 1335             


Ser Gly  Ala Ser Val Thr Glu  Pro Val Ala Glu Glu  Arg Gly Leu 
    1340                 1345                 1350             


Met Ser  Gln Pro Leu Met Glu  Thr Cys His Ser Val  Gly Ala Ala 
    1355                 1360                 1365             


Tyr Leu  Glu Ser Leu Pro Leu  Gln Asp Ala Ser Pro  Ala Gly Gly 
    1370                 1375                 1380             


Pro Ser  Ser Pro Arg Asp Leu  Pro Glu Pro Arg Val  Ser Thr Glu 
    1385                 1390                 1395             


His Thr  Asn Asn Lys Ile Glu  Lys Ile Tyr Ile Met  Lys Ala Asp 
    1400                 1405                 1410             


Thr Val  Ile Val Gly Thr Val  Lys Ala Glu Leu Pro  Glu Gly Arg 
    1415                 1420                 1425             


Gly Leu  Ala Gly Pro Ala Glu  Pro Glu Leu Glu Glu  Glu Leu Glu 
    1430                 1435                 1440             


Ala Asp  His Thr Pro His Tyr  Pro Glu Gln Glu Thr  Glu Pro Pro 
    1445                 1450                 1455             


Leu Gly  Ser Cys Ser Asp Val  Met Leu Ser Val Glu  Glu Glu Gly 
    1460                 1465                 1470             


Lys Glu  Asp Pro Leu Pro Thr  Ala Ala Ser Gly Lys  
    1475                 1480                 1485 


<210> 51
<211> 1475
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Ala Ala Ala 
    1190                 1195                 1200             


Thr Gly  Ala Pro Pro Leu Gly  Thr Gln Pro Asp Cys  Asn Pro Thr 
    1205                 1210                 1215             


Pro Glu  Asn Gly Glu Ala Pro  Ala Ser Thr Ser Pro  Thr Gln Ser 
    1220                 1225                 1230             


Leu Leu  Val Asp Ser Gln Ala  Ser Lys Thr Leu Pro  Ile Pro Thr 
    1235                 1240                 1245             


Ser Ala  Pro Val Ala Leu Ser  Ser Thr Gly Lys Pro  Val Leu Asp 
    1250                 1255                 1260             


Ala Gly  Pro Val Leu Phe Trp  Val Ile Leu Val Leu  Val Val Val 
    1265                 1270                 1275             


Val Gly  Ser Ser Ala Phe Leu  Leu Cys His Arg Arg  Ala Cys Arg 
    1280                 1285                 1290             


Lys Arg  Ile Arg Gln Lys Leu  His Leu Cys Tyr Pro  Val Gln Thr 
    1295                 1300                 1305             


Ser Gln  Pro Lys Leu Glu Leu  Val Asp Ser Arg Pro  Arg Arg Ser 
    1310                 1315                 1320             


Ser Thr  Gln Leu Arg Ser Gly  Ala Ser Val Thr Glu  Pro Val Ala 
    1325                 1330                 1335             


Glu Glu  Arg Gly Leu Met Ser  Gln Pro Leu Met Glu  Thr Cys His 
    1340                 1345                 1350             


Ser Val  Gly Ala Ala Tyr Leu  Glu Ser Leu Pro Leu  Gln Asp Ala 
    1355                 1360                 1365             


Ser Pro  Ala Gly Gly Pro Ser  Ser Pro Arg Asp Leu  Pro Glu Pro 
    1370                 1375                 1380             


Arg Val  Ser Thr Glu His Thr  Asn Asn Lys Ile Glu  Lys Ile Tyr 
    1385                 1390                 1395             


Ile Met  Lys Ala Asp Thr Val  Ile Val Gly Thr Val  Lys Ala Glu 
    1400                 1405                 1410             


Leu Pro  Glu Gly Arg Gly Leu  Ala Gly Pro Ala Glu  Pro Glu Leu 
    1415                 1420                 1425             


Glu Glu  Glu Leu Glu Ala Asp  His Thr Pro His Tyr  Pro Glu Gln 
    1430                 1435                 1440             


Glu Thr  Glu Pro Pro Leu Gly  Ser Cys Ser Asp Val  Met Leu Ser 
    1445                 1450                 1455             


Val Glu  Glu Glu Gly Lys Glu  Asp Pro Leu Pro Thr  Ala Ala Ser 
    1460                 1465                 1470             


Gly Lys  
    1475 


<210> 52
<211> 1325
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Glu Gln Lys 
    1190                 1195                 1200             


Leu Ile  Ser Glu Glu Asp Leu  Ala Ala Ala Thr Gly  Asp Arg Asp 
    1205                 1210                 1215             


Pro Pro  Ala Thr Gln Pro Gln  Glu Thr Gln Gly Pro  Pro Ala Arg 
    1220                 1225                 1230             


Pro Ile  Thr Val Gln Pro Thr  Glu Ala Trp Pro Arg  Thr Ser Gln 
    1235                 1240                 1245             


Gly Pro  Ser Thr Arg Pro Val  Glu Val Pro Gly Gly  Arg Ala Val 
    1250                 1255                 1260             


Ala Ala  Ile Leu Gly Leu Gly  Leu Val Leu Gly Leu  Leu Gly Pro 
    1265                 1270                 1275             


Leu Ala  Ile Leu Leu Ala Leu  Tyr Leu Leu Arg Arg  Asp Gln Arg 
    1280                 1285                 1290             


Leu Pro  Pro Asp Ala His Lys  Pro Pro Gly Gly Gly  Ser Phe Arg 
    1295                 1300                 1305             


Thr Pro  Ile Gln Glu Glu Gln  Ala Asp Ala His Ser  Thr Leu Ala 
    1310                 1315                 1320             


Lys Ile  
    1325 


<210> 53
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Ala Ala Ala 
    1190                 1195                 1200             


Thr Gly  Asp Arg Asp Pro Pro  Ala Thr Gln Pro Gln  Glu Thr Gln 
    1205                 1210                 1215             


Gly Pro  Pro Ala Arg Pro Ile  Thr Val Gln Pro Thr  Glu Ala Trp 
    1220                 1225                 1230             


Pro Arg  Thr Ser Gln Gly Pro  Ser Thr Arg Pro Val  Glu Val Pro 
    1235                 1240                 1245             


Gly Gly  Arg Ala Val Ala Ala  Ile Leu Gly Leu Gly  Leu Val Leu 
    1250                 1255                 1260             


Gly Leu  Leu Gly Pro Leu Ala  Ile Leu Leu Ala Leu  Tyr Leu Leu 
    1265                 1270                 1275             


Arg Arg  Asp Gln Arg Leu Pro  Pro Asp Ala His Lys  Pro Pro Gly 
    1280                 1285                 1290             


Gly Gly  Ser Phe Arg Thr Pro  Ile Gln Glu Glu Gln  Ala Asp Ala 
    1295                 1300                 1305             


His Ser  Thr Leu Ala Lys Ile  
    1310                 1315 


<210> 54
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Glu Gln Lys 
    1190                 1195                 1200             


Leu Ile  Ser Glu Glu Asp Leu  Ala Ala Ala Thr Gly  Thr Thr Thr 
    1205                 1210                 1215             


Pro Ala  Pro Arg Pro Pro Thr  Pro Ala Pro Thr Ile  Ala Ser Gln 
    1220                 1225                 1230             


Pro Leu  Ser Leu Arg Pro Glu  Ala Cys Arg Pro Ala  Ala Gly Gly 
    1235                 1240                 1245             


Ala Val  His Thr Arg Gly Leu  Asp Phe Ala Cys Asp  Ile Tyr Ile 
    1250                 1255                 1260             


Trp Ala  Pro Leu Ala Gly Thr  Cys Gly Val Leu Leu  Leu Ser Leu 
    1265                 1270                 1275             


Val Ile  Thr Leu Tyr Cys Gln  Arg Arg Lys Tyr Arg  Ser Asn Lys 
    1280                 1285                 1290             


Gly Glu  Ser Pro Val Glu Pro  Ala Glu Pro Cys Arg  Tyr Ser Cys 
    1295                 1300                 1305             


Pro Arg  Glu Glu Glu Gly Ser  Thr Ile Pro Ile Gln  Glu Asp Tyr 
    1310                 1315                 1320             


Arg Lys  Pro Glu Pro Ala Cys  Ser Pro 
    1325                 1330         


<210> 55
<211> 1322
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Ala Ala Ala 
    1190                 1195                 1200             


Thr Gly  Thr Thr Thr Pro Ala  Pro Arg Pro Pro Thr  Pro Ala Pro 
    1205                 1210                 1215             


Thr Ile  Ala Ser Gln Pro Leu  Ser Leu Arg Pro Glu  Ala Cys Arg 
    1220                 1225                 1230             


Pro Ala  Ala Gly Gly Ala Val  His Thr Arg Gly Leu  Asp Phe Ala 
    1235                 1240                 1245             


Cys Asp  Ile Tyr Ile Trp Ala  Pro Leu Ala Gly Thr  Cys Gly Val 
    1250                 1255                 1260             


Leu Leu  Leu Ser Leu Val Ile  Thr Leu Tyr Cys Gln  Arg Arg Lys 
    1265                 1270                 1275             


Tyr Arg  Ser Asn Lys Gly Glu  Ser Pro Val Glu Pro  Ala Glu Pro 
    1280                 1285                 1290             


Cys Arg  Tyr Ser Cys Pro Arg  Glu Glu Glu Gly Ser  Thr Ile Pro 
    1295                 1300                 1305             


Ile Gln  Glu Asp Tyr Arg Lys  Pro Glu Pro Ala Cys  Ser Pro 
    1310                 1315                 1320         


<210> 56
<211> 1472
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Glu Gln Lys 
    1190                 1195                 1200             


Leu Ile  Ser Glu Glu Asp Leu  Ala Ala Ala Thr Gly  Thr Thr Thr 
    1205                 1210                 1215             


Pro Ala  Pro Arg Pro Pro Thr  Pro Ala Pro Thr Ile  Ala Ser Gln 
    1220                 1225                 1230             


Pro Leu  Ser Leu Arg Pro Glu  Ala Cys Arg Pro Ala  Ala Gly Gly 
    1235                 1240                 1245             


Ala Val  His Thr Arg Gly Leu  Asp Phe Ala Cys Asp  Ile Tyr Ile 
    1250                 1255                 1260             


Trp Ala  Pro Leu Ala Gly Thr  Cys Gly Val Leu Leu  Leu Ser Leu 
    1265                 1270                 1275             


Val Ile  Thr Leu Tyr Cys His  Arg Arg Ala Cys Arg  Lys Arg Ile 
    1280                 1285                 1290             


Arg Gln  Lys Leu His Leu Cys  Tyr Pro Val Gln Thr  Ser Gln Pro 
    1295                 1300                 1305             


Lys Leu  Glu Leu Val Asp Ser  Arg Pro Arg Arg Ser  Ser Thr Gln 
    1310                 1315                 1320             


Leu Arg  Ser Gly Ala Ser Val  Thr Glu Pro Val Ala  Glu Glu Arg 
    1325                 1330                 1335             


Gly Leu  Met Ser Gln Pro Leu  Met Glu Thr Cys His  Ser Val Gly 
    1340                 1345                 1350             


Ala Ala  Tyr Leu Glu Ser Leu  Pro Leu Gln Asp Ala  Ser Pro Ala 
    1355                 1360                 1365             


Gly Gly  Pro Ser Ser Pro Arg  Asp Leu Pro Glu Pro  Arg Val Ser 
    1370                 1375                 1380             


Thr Glu  His Thr Asn Asn Lys  Ile Glu Lys Ile Tyr  Ile Met Lys 
    1385                 1390                 1395             


Ala Asp  Thr Val Ile Val Gly  Thr Val Lys Ala Glu  Leu Pro Glu 
    1400                 1405                 1410             


Gly Arg  Gly Leu Ala Gly Pro  Ala Glu Pro Glu Leu  Glu Glu Glu 
    1415                 1420                 1425             


Leu Glu  Ala Asp His Thr Pro  His Tyr Pro Glu Gln  Glu Thr Glu 
    1430                 1435                 1440             


Pro Pro  Leu Gly Ser Cys Ser  Asp Val Met Leu Ser  Val Glu Glu 
    1445                 1450                 1455             


Glu Gly  Lys Glu Asp Pro Leu  Pro Thr Ala Ala Ser  Gly Lys 
    1460                 1465                 1470         


<210> 57
<211> 1462
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Ala Ala Ala 
    1190                 1195                 1200             


Thr Gly  Thr Thr Thr Pro Ala  Pro Arg Pro Pro Thr  Pro Ala Pro 
    1205                 1210                 1215             


Thr Ile  Ala Ser Gln Pro Leu  Ser Leu Arg Pro Glu  Ala Cys Arg 
    1220                 1225                 1230             


Pro Ala  Ala Gly Gly Ala Val  His Thr Arg Gly Leu  Asp Phe Ala 
    1235                 1240                 1245             


Cys Asp  Ile Tyr Ile Trp Ala  Pro Leu Ala Gly Thr  Cys Gly Val 
    1250                 1255                 1260             


Leu Leu  Leu Ser Leu Val Ile  Thr Leu Tyr Cys His  Arg Arg Ala 
    1265                 1270                 1275             


Cys Arg  Lys Arg Ile Arg Gln  Lys Leu His Leu Cys  Tyr Pro Val 
    1280                 1285                 1290             


Gln Thr  Ser Gln Pro Lys Leu  Glu Leu Val Asp Ser  Arg Pro Arg 
    1295                 1300                 1305             


Arg Ser  Ser Thr Gln Leu Arg  Ser Gly Ala Ser Val  Thr Glu Pro 
    1310                 1315                 1320             


Val Ala  Glu Glu Arg Gly Leu  Met Ser Gln Pro Leu  Met Glu Thr 
    1325                 1330                 1335             


Cys His  Ser Val Gly Ala Ala  Tyr Leu Glu Ser Leu  Pro Leu Gln 
    1340                 1345                 1350             


Asp Ala  Ser Pro Ala Gly Gly  Pro Ser Ser Pro Arg  Asp Leu Pro 
    1355                 1360                 1365             


Glu Pro  Arg Val Ser Thr Glu  His Thr Asn Asn Lys  Ile Glu Lys 
    1370                 1375                 1380             


Ile Tyr  Ile Met Lys Ala Asp  Thr Val Ile Val Gly  Thr Val Lys 
    1385                 1390                 1395             


Ala Glu  Leu Pro Glu Gly Arg  Gly Leu Ala Gly Pro  Ala Glu Pro 
    1400                 1405                 1410             


Glu Leu  Glu Glu Glu Leu Glu  Ala Asp His Thr Pro  His Tyr Pro 
    1415                 1420                 1425             


Glu Gln  Glu Thr Glu Pro Pro  Leu Gly Ser Cys Ser  Asp Val Met 
    1430                 1435                 1440             


Leu Ser  Val Glu Glu Glu Gly  Lys Glu Asp Pro Leu  Pro Thr Ala 
    1445                 1450                 1455             


Ala Ser  Gly Lys 
    1460         


<210> 58
<211> 1326
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Glu Gln Lys 
    1190                 1195                 1200             


Leu Ile  Ser Glu Glu Asp Leu  Ala Ala Ala Thr Gly  Thr Thr Thr 
    1205                 1210                 1215             


Pro Ala  Pro Arg Pro Pro Thr  Pro Ala Pro Thr Ile  Ala Ser Gln 
    1220                 1225                 1230             


Pro Leu  Ser Leu Arg Pro Glu  Ala Cys Arg Pro Ala  Ala Gly Gly 
    1235                 1240                 1245             


Ala Val  His Thr Arg Gly Leu  Asp Phe Ala Cys Asp  Ile Tyr Ile 
    1250                 1255                 1260             


Trp Ala  Pro Leu Ala Gly Thr  Cys Gly Val Leu Leu  Leu Ser Leu 
    1265                 1270                 1275             


Val Ile  Thr Leu Tyr Cys Ala  Leu Tyr Leu Leu Arg  Arg Asp Gln 
    1280                 1285                 1290             


Arg Leu  Pro Pro Asp Ala His  Lys Pro Pro Gly Gly  Gly Ser Phe 
    1295                 1300                 1305             


Arg Thr  Pro Ile Gln Glu Glu  Gln Ala Asp Ala His  Ser Thr Leu 
    1310                 1315                 1320             


Ala Lys  Ile 
    1325     


<210> 59
<211> 1316
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
945                 950                 955                 960 


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
                965                 970                 975     


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            980                 985                 990         


Asn Leu Leu Ile Tyr Ala Ala Ser  Asn Leu Gln Thr Gly  Val Pro Ser 
        995                 1000                 1005             


Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1010                 1015                 1020             


Ser Ser  Leu Gln Pro Glu Asp  Ile Ala Thr Tyr Tyr  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asp  Gly Leu Pro Leu Thr  Phe Gly Gln Gly Thr  Arg Leu Glu 
    1040                 1045                 1050             


Ile Lys  Arg Ser Arg Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gly Gly  Gly Gly Ser Leu Glu  Met Ala Gln Val Gln  Leu Val Glu 
    1070                 1075                 1080             


Ser Gly  Gly Gly Leu Val Gln  Pro Gly Gly Ser Leu  Arg Leu Ser 
    1085                 1090                 1095             


Cys Ala  Ala Ser Gly Phe Thr  Phe Ser Asn Tyr Ala  Met Ser Trp 
    1100                 1105                 1110             


Val Arg  Gln Ala Pro Gly Lys  Gly Leu Glu Trp Val  Ser Ser Ile 
    1115                 1120                 1125             


Ser Gly  Ser Gly Gly Ser Thr  Tyr Tyr Ala Asp Ser  Val Lys Gly 
    1130                 1135                 1140             


Arg Phe  Thr Ile Ser Arg Asp  Thr Ser Lys Asn Thr  Leu Tyr Leu 
    1145                 1150                 1155             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1160                 1165                 1170             


Ala Arg  Tyr Gly Ser Ala Ala  Trp Met Asp Ser Trp  Gly Gln Gly 
    1175                 1180                 1185             


Thr Leu  Val Thr Val Ser Ser  Val Thr Val Ser Ser  Ala Ala Ala 
    1190                 1195                 1200             


Thr Gly  Thr Thr Thr Pro Ala  Pro Arg Pro Pro Thr  Pro Ala Pro 
    1205                 1210                 1215             


Thr Ile  Ala Ser Gln Pro Leu  Ser Leu Arg Pro Glu  Ala Cys Arg 
    1220                 1225                 1230             


Pro Ala  Ala Gly Gly Ala Val  His Thr Arg Gly Leu  Asp Phe Ala 
    1235                 1240                 1245             


Cys Asp  Ile Tyr Ile Trp Ala  Pro Leu Ala Gly Thr  Cys Gly Val 
    1250                 1255                 1260             


Leu Leu  Leu Ser Leu Val Ile  Thr Leu Tyr Cys Ala  Leu Tyr Leu 
    1265                 1270                 1275             


Leu Arg  Arg Asp Gln Arg Leu  Pro Pro Asp Ala His  Lys Pro Pro 
    1280                 1285                 1290             


Gly Gly  Gly Ser Phe Arg Thr  Pro Ile Gln Glu Glu  Gln Ala Asp 
    1295                 1300                 1305             


Ala His  Ser Thr Leu Ala Lys  Ile 
    1310                 1315     


<210> 60
<211> 1585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Glu Gln Lys Leu Ile  Ser Glu Glu 
    1460                 1465                 1470             


Asp Leu  Ala Ala Ala Ile Glu  Val Met Tyr Pro Pro  Pro Tyr Leu 
    1475                 1480                 1485             


Asp Asn  Glu Lys Ser Asn Gly  Thr Ile Ile His Val  Lys Gly Lys 
    1490                 1495                 1500             


His Leu  Cys Pro Ser Pro Leu  Phe Pro Gly Pro Ser  Lys Pro Phe 
    1505                 1510                 1515             


Trp Val  Leu Val Val Val Gly  Gly Val Leu Ala Cys  Tyr Ser Leu 
    1520                 1525                 1530             


Leu Val  Thr Val Ala Phe Ile  Ile Phe Trp Val Arg  Ser Lys Arg 
    1535                 1540                 1545             


Ser Arg  Leu Leu His Ser Asp  Tyr Met Asn Met Thr  Pro Arg Arg 
    1550                 1555                 1560             


Pro Gly  Pro Thr Arg Lys His  Tyr Gln Pro Tyr Ala  Pro Pro Arg 
    1565                 1570                 1575             


Asp Phe  Ala Ala Tyr Arg Ser  
    1580                 1585 


<210> 61
<211> 1575
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Ala Ala Ala Ile Glu  Val Met Tyr 
    1460                 1465                 1470             


Pro Pro  Pro Tyr Leu Asp Asn  Glu Lys Ser Asn Gly  Thr Ile Ile 
    1475                 1480                 1485             


His Val  Lys Gly Lys His Leu  Cys Pro Ser Pro Leu  Phe Pro Gly 
    1490                 1495                 1500             


Pro Ser  Lys Pro Phe Trp Val  Leu Val Val Val Gly  Gly Val Leu 
    1505                 1510                 1515             


Ala Cys  Tyr Ser Leu Leu Val  Thr Val Ala Phe Ile  Ile Phe Trp 
    1520                 1525                 1530             


Val Arg  Ser Lys Arg Ser Arg  Leu Leu His Ser Asp  Tyr Met Asn 
    1535                 1540                 1545             


Met Thr  Pro Arg Arg Pro Gly  Pro Thr Arg Lys His  Tyr Gln Pro 
    1550                 1555                 1560             


Tyr Ala  Pro Pro Arg Asp Phe  Ala Ala Tyr Arg Ser  
    1565                 1570                 1575 


<210> 62
<211> 1574
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Glu Gln Lys Leu Ile  Ser Glu Glu 
    1460                 1465                 1470             


Asp Leu  Ala Ala Ala Thr Gly  Pro Ala Asp Leu Ser  Pro Gly Ala 
    1475                 1480                 1485             


Ser Ser  Val Thr Pro Pro Ala  Pro Ala Arg Glu Pro  Gly His Ser 
    1490                 1495                 1500             


Pro Gln  Ile Ile Ser Phe Phe  Leu Ala Leu Thr Ser  Thr Ala Leu 
    1505                 1510                 1515             


Leu Phe  Leu Leu Phe Phe Leu  Thr Leu Arg Phe Ser  Val Val Lys 
    1520                 1525                 1530             


Arg Gly  Arg Lys Lys Leu Leu  Tyr Ile Phe Lys Gln  Pro Phe Met 
    1535                 1540                 1545             


Arg Pro  Val Gln Thr Thr Gln  Glu Glu Asp Gly Cys  Ser Cys Arg 
    1550                 1555                 1560             


Phe Pro  Glu Glu Glu Glu Gly  Gly Cys Glu Leu 
    1565                 1570                 


<210> 63
<211> 1564
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Ala Ala Ala Thr Gly  Pro Ala Asp 
    1460                 1465                 1470             


Leu Ser  Pro Gly Ala Ser Ser  Val Thr Pro Pro Ala  Pro Ala Arg 
    1475                 1480                 1485             


Glu Pro  Gly His Ser Pro Gln  Ile Ile Ser Phe Phe  Leu Ala Leu 
    1490                 1495                 1500             


Thr Ser  Thr Ala Leu Leu Phe  Leu Leu Phe Phe Leu  Thr Leu Arg 
    1505                 1510                 1515             


Phe Ser  Val Val Lys Arg Gly  Arg Lys Lys Leu Leu  Tyr Ile Phe 
    1520                 1525                 1530             


Lys Gln  Pro Phe Met Arg Pro  Val Gln Thr Thr Gln  Glu Glu Asp 
    1535                 1540                 1545             


Gly Cys  Ser Cys Arg Phe Pro  Glu Glu Glu Glu Gly  Gly Cys Glu 
    1550                 1555                 1560             


Leu 
    


<210> 64
<211> 1599
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Glu Gln Lys Leu Ile  Ser Glu Glu 
    1460                 1465                 1470             


Asp Leu  Ala Ala Ala Thr Gly  Pro Thr His Leu Pro  Tyr Val Ser 
    1475                 1480                 1485             


Glu Met  Leu Glu Ala Arg Thr  Ala Gly His Met Gln  Thr Leu Ala 
    1490                 1495                 1500             


Asp Phe  Arg Gln Leu Pro Ala  Arg Thr Leu Ser Thr  His Trp Pro 
    1505                 1510                 1515             


Pro Gln  Arg Ser Leu Cys Ser  Ser Asp Phe Ile Arg  Ile Leu Val 
    1520                 1525                 1530             


Ile Phe  Ser Gly Met Phe Leu  Val Phe Thr Leu Ala  Gly Ala Leu 
    1535                 1540                 1545             


Phe Leu  His Gln Arg Arg Lys  Tyr Arg Ser Asn Lys  Gly Glu Ser 
    1550                 1555                 1560             


Pro Val  Glu Pro Ala Glu Pro  Cys Arg Tyr Ser Cys  Pro Arg Glu 
    1565                 1570                 1575             


Glu Glu  Gly Ser Thr Ile Pro  Ile Gln Glu Asp Tyr  Arg Lys Pro 
    1580                 1585                 1590             


Glu Pro  Ala Cys Ser Pro 
    1595                 


<210> 65
<211> 1589
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Ala Ala Ala Thr Gly  Pro Thr His 
    1460                 1465                 1470             


Leu Pro  Tyr Val Ser Glu Met  Leu Glu Ala Arg Thr  Ala Gly His 
    1475                 1480                 1485             


Met Gln  Thr Leu Ala Asp Phe  Arg Gln Leu Pro Ala  Arg Thr Leu 
    1490                 1495                 1500             


Ser Thr  His Trp Pro Pro Gln  Arg Ser Leu Cys Ser  Ser Asp Phe 
    1505                 1510                 1515             


Ile Arg  Ile Leu Val Ile Phe  Ser Gly Met Phe Leu  Val Phe Thr 
    1520                 1525                 1530             


Leu Ala  Gly Ala Leu Phe Leu  His Gln Arg Arg Lys  Tyr Arg Ser 
    1535                 1540                 1545             


Asn Lys  Gly Glu Ser Pro Val  Glu Pro Ala Glu Pro  Cys Arg Tyr 
    1550                 1555                 1560             


Ser Cys  Pro Arg Glu Glu Glu  Gly Ser Thr Ile Pro  Ile Gln Glu 
    1565                 1570                 1575             


Asp Tyr  Arg Lys Pro Glu Pro  Ala Cys Ser Pro 
    1580                 1585                 


<210> 66
<211> 1750
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Glu Gln Lys Leu Ile  Ser Glu Glu 
    1460                 1465                 1470             


Asp Leu  Ala Ala Ala Thr Gly  Ala Pro Pro Leu Gly  Thr Gln Pro 
    1475                 1480                 1485             


Asp Cys  Asn Pro Thr Pro Glu  Asn Gly Glu Ala Pro  Ala Ser Thr 
    1490                 1495                 1500             


Ser Pro  Thr Gln Ser Leu Leu  Val Asp Ser Gln Ala  Ser Lys Thr 
    1505                 1510                 1515             


Leu Pro  Ile Pro Thr Ser Ala  Pro Val Ala Leu Ser  Ser Thr Gly 
    1520                 1525                 1530             


Lys Pro  Val Leu Asp Ala Gly  Pro Val Leu Phe Trp  Val Ile Leu 
    1535                 1540                 1545             


Val Leu  Val Val Val Val Gly  Ser Ser Ala Phe Leu  Leu Cys His 
    1550                 1555                 1560             


Arg Arg  Ala Cys Arg Lys Arg  Ile Arg Gln Lys Leu  His Leu Cys 
    1565                 1570                 1575             


Tyr Pro  Val Gln Thr Ser Gln  Pro Lys Leu Glu Leu  Val Asp Ser 
    1580                 1585                 1590             


Arg Pro  Arg Arg Ser Ser Thr  Gln Leu Arg Ser Gly  Ala Ser Val 
    1595                 1600                 1605             


Thr Glu  Pro Val Ala Glu Glu  Arg Gly Leu Met Ser  Gln Pro Leu 
    1610                 1615                 1620             


Met Glu  Thr Cys His Ser Val  Gly Ala Ala Tyr Leu  Glu Ser Leu 
    1625                 1630                 1635             


Pro Leu  Gln Asp Ala Ser Pro  Ala Gly Gly Pro Ser  Ser Pro Arg 
    1640                 1645                 1650             


Asp Leu  Pro Glu Pro Arg Val  Ser Thr Glu His Thr  Asn Asn Lys 
    1655                 1660                 1665             


Ile Glu  Lys Ile Tyr Ile Met  Lys Ala Asp Thr Val  Ile Val Gly 
    1670                 1675                 1680             


Thr Val  Lys Ala Glu Leu Pro  Glu Gly Arg Gly Leu  Ala Gly Pro 
    1685                 1690                 1695             


Ala Glu  Pro Glu Leu Glu Glu  Glu Leu Glu Ala Asp  His Thr Pro 
    1700                 1705                 1710             


His Tyr  Pro Glu Gln Glu Thr  Glu Pro Pro Leu Gly  Ser Cys Ser 
    1715                 1720                 1725             


Asp Val  Met Leu Ser Val Glu  Glu Glu Gly Lys Glu  Asp Pro Leu 
    1730                 1735                 1740             


Pro Thr  Ala Ala Ser Gly Lys  
    1745                 1750 


<210> 67
<211> 1740
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Ala Ala Ala Thr Gly  Ala Pro Pro 
    1460                 1465                 1470             


Leu Gly  Thr Gln Pro Asp Cys  Asn Pro Thr Pro Glu  Asn Gly Glu 
    1475                 1480                 1485             


Ala Pro  Ala Ser Thr Ser Pro  Thr Gln Ser Leu Leu  Val Asp Ser 
    1490                 1495                 1500             


Gln Ala  Ser Lys Thr Leu Pro  Ile Pro Thr Ser Ala  Pro Val Ala 
    1505                 1510                 1515             


Leu Ser  Ser Thr Gly Lys Pro  Val Leu Asp Ala Gly  Pro Val Leu 
    1520                 1525                 1530             


Phe Trp  Val Ile Leu Val Leu  Val Val Val Val Gly  Ser Ser Ala 
    1535                 1540                 1545             


Phe Leu  Leu Cys His Arg Arg  Ala Cys Arg Lys Arg  Ile Arg Gln 
    1550                 1555                 1560             


Lys Leu  His Leu Cys Tyr Pro  Val Gln Thr Ser Gln  Pro Lys Leu 
    1565                 1570                 1575             


Glu Leu  Val Asp Ser Arg Pro  Arg Arg Ser Ser Thr  Gln Leu Arg 
    1580                 1585                 1590             


Ser Gly  Ala Ser Val Thr Glu  Pro Val Ala Glu Glu  Arg Gly Leu 
    1595                 1600                 1605             


Met Ser  Gln Pro Leu Met Glu  Thr Cys His Ser Val  Gly Ala Ala 
    1610                 1615                 1620             


Tyr Leu  Glu Ser Leu Pro Leu  Gln Asp Ala Ser Pro  Ala Gly Gly 
    1625                 1630                 1635             


Pro Ser  Ser Pro Arg Asp Leu  Pro Glu Pro Arg Val  Ser Thr Glu 
    1640                 1645                 1650             


His Thr  Asn Asn Lys Ile Glu  Lys Ile Tyr Ile Met  Lys Ala Asp 
    1655                 1660                 1665             


Thr Val  Ile Val Gly Thr Val  Lys Ala Glu Leu Pro  Glu Gly Arg 
    1670                 1675                 1680             


Gly Leu  Ala Gly Pro Ala Glu  Pro Glu Leu Glu Glu  Glu Leu Glu 
    1685                 1690                 1695             


Ala Asp  His Thr Pro His Tyr  Pro Glu Gln Glu Thr  Glu Pro Pro 
    1700                 1705                 1710             


Leu Gly  Ser Cys Ser Asp Val  Met Leu Ser Val Glu  Glu Glu Gly 
    1715                 1720                 1725             


Lys Glu  Asp Pro Leu Pro Thr  Ala Ala Ser Gly Lys  
    1730                 1735                 1740 


<210> 68
<211> 1590
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Glu Gln Lys Leu Ile  Ser Glu Glu 
    1460                 1465                 1470             


Asp Leu  Ala Ala Ala Thr Gly  Asp Arg Asp Pro Pro  Ala Thr Gln 
    1475                 1480                 1485             


Pro Gln  Glu Thr Gln Gly Pro  Pro Ala Arg Pro Ile  Thr Val Gln 
    1490                 1495                 1500             


Pro Thr  Glu Ala Trp Pro Arg  Thr Ser Gln Gly Pro  Ser Thr Arg 
    1505                 1510                 1515             


Pro Val  Glu Val Pro Gly Gly  Arg Ala Val Ala Ala  Ile Leu Gly 
    1520                 1525                 1530             


Leu Gly  Leu Val Leu Gly Leu  Leu Gly Pro Leu Ala  Ile Leu Leu 
    1535                 1540                 1545             


Ala Leu  Tyr Leu Leu Arg Arg  Asp Gln Arg Leu Pro  Pro Asp Ala 
    1550                 1555                 1560             


His Lys  Pro Pro Gly Gly Gly  Ser Phe Arg Thr Pro  Ile Gln Glu 
    1565                 1570                 1575             


Glu Gln  Ala Asp Ala His Ser  Thr Leu Ala Lys Ile  
    1580                 1585                 1590 


<210> 69
<211> 1580
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Ala Ala Ala Thr Gly  Asp Arg Asp 
    1460                 1465                 1470             


Pro Pro  Ala Thr Gln Pro Gln  Glu Thr Gln Gly Pro  Pro Ala Arg 
    1475                 1480                 1485             


Pro Ile  Thr Val Gln Pro Thr  Glu Ala Trp Pro Arg  Thr Ser Gln 
    1490                 1495                 1500             


Gly Pro  Ser Thr Arg Pro Val  Glu Val Pro Gly Gly  Arg Ala Val 
    1505                 1510                 1515             


Ala Ala  Ile Leu Gly Leu Gly  Leu Val Leu Gly Leu  Leu Gly Pro 
    1520                 1525                 1530             


Leu Ala  Ile Leu Leu Ala Leu  Tyr Leu Leu Arg Arg  Asp Gln Arg 
    1535                 1540                 1545             


Leu Pro  Pro Asp Ala His Lys  Pro Pro Gly Gly Gly  Ser Phe Arg 
    1550                 1555                 1560             


Thr Pro  Ile Gln Glu Glu Gln  Ala Asp Ala His Ser  Thr Leu Ala 
    1565                 1570                 1575             


Lys Ile  
    1580 


<210> 70
<211> 1597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Glu Gln Lys Leu Ile  Ser Glu Glu 
    1460                 1465                 1470             


Asp Leu  Ala Ala Ala Thr Gly  Thr Thr Thr Pro Ala  Pro Arg Pro 
    1475                 1480                 1485             


Pro Thr  Pro Ala Pro Thr Ile  Ala Ser Gln Pro Leu  Ser Leu Arg 
    1490                 1495                 1500             


Pro Glu  Ala Cys Arg Pro Ala  Ala Gly Gly Ala Val  His Thr Arg 
    1505                 1510                 1515             


Gly Leu  Asp Phe Ala Cys Asp  Ile Tyr Ile Trp Ala  Pro Leu Ala 
    1520                 1525                 1530             


Gly Thr  Cys Gly Val Leu Leu  Leu Ser Leu Val Ile  Thr Leu Tyr 
    1535                 1540                 1545             


Cys Gln  Arg Arg Lys Tyr Arg  Ser Asn Lys Gly Glu  Ser Pro Val 
    1550                 1555                 1560             


Glu Pro  Ala Glu Pro Cys Arg  Tyr Ser Cys Pro Arg  Glu Glu Glu 
    1565                 1570                 1575             


Gly Ser  Thr Ile Pro Ile Gln  Glu Asp Tyr Arg Lys  Pro Glu Pro 
    1580                 1585                 1590             


Ala Cys  Ser Pro 
    1595         


<210> 71
<211> 1587
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Ala Ala Ala Thr Gly  Thr Thr Thr 
    1460                 1465                 1470             


Pro Ala  Pro Arg Pro Pro Thr  Pro Ala Pro Thr Ile  Ala Ser Gln 
    1475                 1480                 1485             


Pro Leu  Ser Leu Arg Pro Glu  Ala Cys Arg Pro Ala  Ala Gly Gly 
    1490                 1495                 1500             


Ala Val  His Thr Arg Gly Leu  Asp Phe Ala Cys Asp  Ile Tyr Ile 
    1505                 1510                 1515             


Trp Ala  Pro Leu Ala Gly Thr  Cys Gly Val Leu Leu  Leu Ser Leu 
    1520                 1525                 1530             


Val Ile  Thr Leu Tyr Cys Gln  Arg Arg Lys Tyr Arg  Ser Asn Lys 
    1535                 1540                 1545             


Gly Glu  Ser Pro Val Glu Pro  Ala Glu Pro Cys Arg  Tyr Ser Cys 
    1550                 1555                 1560             


Pro Arg  Glu Glu Glu Gly Ser  Thr Ile Pro Ile Gln  Glu Asp Tyr 
    1565                 1570                 1575             


Arg Lys  Pro Glu Pro Ala Cys  Ser Pro 
    1580                 1585         


<210> 72
<211> 1737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Glu Gln Lys Leu Ile  Ser Glu Glu 
    1460                 1465                 1470             


Asp Leu  Ala Ala Ala Thr Gly  Thr Thr Thr Pro Ala  Pro Arg Pro 
    1475                 1480                 1485             


Pro Thr  Pro Ala Pro Thr Ile  Ala Ser Gln Pro Leu  Ser Leu Arg 
    1490                 1495                 1500             


Pro Glu  Ala Cys Arg Pro Ala  Ala Gly Gly Ala Val  His Thr Arg 
    1505                 1510                 1515             


Gly Leu  Asp Phe Ala Cys Asp  Ile Tyr Ile Trp Ala  Pro Leu Ala 
    1520                 1525                 1530             


Gly Thr  Cys Gly Val Leu Leu  Leu Ser Leu Val Ile  Thr Leu Tyr 
    1535                 1540                 1545             


Cys His  Arg Arg Ala Cys Arg  Lys Arg Ile Arg Gln  Lys Leu His 
    1550                 1555                 1560             


Leu Cys  Tyr Pro Val Gln Thr  Ser Gln Pro Lys Leu  Glu Leu Val 
    1565                 1570                 1575             


Asp Ser  Arg Pro Arg Arg Ser  Ser Thr Gln Leu Arg  Ser Gly Ala 
    1580                 1585                 1590             


Ser Val  Thr Glu Pro Val Ala  Glu Glu Arg Gly Leu  Met Ser Gln 
    1595                 1600                 1605             


Pro Leu  Met Glu Thr Cys His  Ser Val Gly Ala Ala  Tyr Leu Glu 
    1610                 1615                 1620             


Ser Leu  Pro Leu Gln Asp Ala  Ser Pro Ala Gly Gly  Pro Ser Ser 
    1625                 1630                 1635             


Pro Arg  Asp Leu Pro Glu Pro  Arg Val Ser Thr Glu  His Thr Asn 
    1640                 1645                 1650             


Asn Lys  Ile Glu Lys Ile Tyr  Ile Met Lys Ala Asp  Thr Val Ile 
    1655                 1660                 1665             


Val Gly  Thr Val Lys Ala Glu  Leu Pro Glu Gly Arg  Gly Leu Ala 
    1670                 1675                 1680             


Gly Pro  Ala Glu Pro Glu Leu  Glu Glu Glu Leu Glu  Ala Asp His 
    1685                 1690                 1695             


Thr Pro  His Tyr Pro Glu Gln  Glu Thr Glu Pro Pro  Leu Gly Ser 
    1700                 1705                 1710             


Cys Ser  Asp Val Met Leu Ser  Val Glu Glu Glu Gly  Lys Glu Asp 
    1715                 1720                 1725             


Pro Leu  Pro Thr Ala Ala Ser  Gly Lys 
    1730                 1735         


<210> 73
<211> 1727
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Ala Ala Ala Thr Gly  Thr Thr Thr 
    1460                 1465                 1470             


Pro Ala  Pro Arg Pro Pro Thr  Pro Ala Pro Thr Ile  Ala Ser Gln 
    1475                 1480                 1485             


Pro Leu  Ser Leu Arg Pro Glu  Ala Cys Arg Pro Ala  Ala Gly Gly 
    1490                 1495                 1500             


Ala Val  His Thr Arg Gly Leu  Asp Phe Ala Cys Asp  Ile Tyr Ile 
    1505                 1510                 1515             


Trp Ala  Pro Leu Ala Gly Thr  Cys Gly Val Leu Leu  Leu Ser Leu 
    1520                 1525                 1530             


Val Ile  Thr Leu Tyr Cys His  Arg Arg Ala Cys Arg  Lys Arg Ile 
    1535                 1540                 1545             


Arg Gln  Lys Leu His Leu Cys  Tyr Pro Val Gln Thr  Ser Gln Pro 
    1550                 1555                 1560             


Lys Leu  Glu Leu Val Asp Ser  Arg Pro Arg Arg Ser  Ser Thr Gln 
    1565                 1570                 1575             


Leu Arg  Ser Gly Ala Ser Val  Thr Glu Pro Val Ala  Glu Glu Arg 
    1580                 1585                 1590             


Gly Leu  Met Ser Gln Pro Leu  Met Glu Thr Cys His  Ser Val Gly 
    1595                 1600                 1605             


Ala Ala  Tyr Leu Glu Ser Leu  Pro Leu Gln Asp Ala  Ser Pro Ala 
    1610                 1615                 1620             


Gly Gly  Pro Ser Ser Pro Arg  Asp Leu Pro Glu Pro  Arg Val Ser 
    1625                 1630                 1635             


Thr Glu  His Thr Asn Asn Lys  Ile Glu Lys Ile Tyr  Ile Met Lys 
    1640                 1645                 1650             


Ala Asp  Thr Val Ile Val Gly  Thr Val Lys Ala Glu  Leu Pro Glu 
    1655                 1660                 1665             


Gly Arg  Gly Leu Ala Gly Pro  Ala Glu Pro Glu Leu  Glu Glu Glu 
    1670                 1675                 1680             


Leu Glu  Ala Asp His Thr Pro  His Tyr Pro Glu Gln  Glu Thr Glu 
    1685                 1690                 1695             


Pro Pro  Leu Gly Ser Cys Ser  Asp Val Met Leu Ser  Val Glu Glu 
    1700                 1705                 1710             


Glu Gly  Lys Glu Asp Pro Leu  Pro Thr Ala Ala Ser  Gly Lys 
    1715                 1720                 1725         


<210> 74
<211> 1591
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Glu Gln Lys Leu Ile  Ser Glu Glu 
    1460                 1465                 1470             


Asp Leu  Ala Ala Ala Thr Gly  Thr Thr Thr Pro Ala  Pro Arg Pro 
    1475                 1480                 1485             


Pro Thr  Pro Ala Pro Thr Ile  Ala Ser Gln Pro Leu  Ser Leu Arg 
    1490                 1495                 1500             


Pro Glu  Ala Cys Arg Pro Ala  Ala Gly Gly Ala Val  His Thr Arg 
    1505                 1510                 1515             


Gly Leu  Asp Phe Ala Cys Asp  Ile Tyr Ile Trp Ala  Pro Leu Ala 
    1520                 1525                 1530             


Gly Thr  Cys Gly Val Leu Leu  Leu Ser Leu Val Ile  Thr Leu Tyr 
    1535                 1540                 1545             


Cys Ala  Leu Tyr Leu Leu Arg  Arg Asp Gln Arg Leu  Pro Pro Asp 
    1550                 1555                 1560             


Ala His  Lys Pro Pro Gly Gly  Gly Ser Phe Arg Thr  Pro Ile Gln 
    1565                 1570                 1575             


Glu Glu  Gln Ala Asp Ala His  Ser Thr Leu Ala Lys  Ile 
    1580                 1585                 1590     


<210> 75
<211> 1581
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 75
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
        275                 280                 285             


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
                325                 330                 335     


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
            340                 345                 350         


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
    370                 375                 380                 


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr 
            500                 505                 510         


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
        515                 520                 525             


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
    530                 535                 540                 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
545                 550                 555                 560 


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
            580                 585                 590         


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr 
        595                 600                 605             


Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
    610                 615                 620                 


Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
625                 630                 635                 640 


Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser 
                645                 650                 655     


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
            660                 665                 670         


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
        675                 680                 685             


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp 
705                 710                 715                 720 


Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                725                 730                 735     


Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            740                 745                 750         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        755                 760                 765             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
    770                 775                 780                 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
785                 790                 795                 800 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                805                 810                 815     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            820                 825                 830         


Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp Val Ile Thr Met 
        835                 840                 845             


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
    850                 855                 860                 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
865                 870                 875                 880 


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
                885                 890                 895     


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser Gly Ser Gly Ala Thr Asn 
            900                 905                 910         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        915                 920                 925             


Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
    930                 935                 940                 


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
945                 950                 955                 960 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                965                 970                 975     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            980                 985                 990         


Leu Val Val Tyr Asp Asp Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Asn Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser 
    1010                 1015                 1020             


Arg Val  Glu Ala Gly Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Trp 
    1025                 1030                 1035             


Asp Ser  Ser Ser Asp Tyr Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1040                 1045                 1050             


Thr Val  Leu Gly Ser Arg Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser Leu  Glu Met Ala Glu Val  Gln Leu Val 
    1070                 1075                 1080             


Gln Ser  Gly Ala Glu Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile 
    1085                 1090                 1095             


Ser Cys  Lys Gly Ser Gly Tyr  Ser Phe Thr Ser Tyr  Trp Ile Gly 
    1100                 1105                 1110             


Trp Val  Arg Gln Met Pro Gly  Lys Gly Leu Glu Trp  Met Gly Ile 
    1115                 1120                 1125             


Ile Tyr  Pro Gly Asp Ser Asp  Thr Arg Tyr Ser Pro  Ser Phe Gln 
    1130                 1135                 1140             


Gly Gln  Val Thr Ile Ser Ala  Asp Lys Ser Ile Ser  Thr Ala Tyr 
    1145                 1150                 1155             


Leu Gln  Trp Ser Ser Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr 
    1160                 1165                 1170             


Cys Ala  Arg Gln Val Trp Gly  Trp Gln Gly Gly Met  Tyr Pro Arg 
    1175                 1180                 1185             


Ser Asn  Trp Trp Tyr Asn Leu  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1190                 1195                 1200             


Val Thr  Val Ser Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gln Ile  Val Leu Ser Gln Ser  Pro Ala Ile Leu Ser  Ala Ser Pro 
    1220                 1225                 1230             


Gly Glu  Lys Val Thr Met Thr  Cys Arg Ala Ser Ser  Ser Val Ser 
    1235                 1240                 1245             


Tyr Ile  His Trp Phe Gln Gln  Lys Pro Gly Ser Ser  Pro Lys Pro 
    1250                 1255                 1260             


Trp Ile  Tyr Ala Thr Ser Asn  Leu Ala Ser Gly Val  Pro Val Arg 
    1265                 1270                 1275             


Phe Ser  Gly Ser Gly Ser Gly  Thr Ser Tyr Ser Leu  Thr Ile Ser 
    1280                 1285                 1290             


Arg Val  Glu Ala Glu Asp Ala  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1295                 1300                 1305             


Thr Ser  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Glu Ile 
    1310                 1315                 1320             


Lys Arg  Ser Arg Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Leu Glu Gln  Val Gln Leu Gln Gln  Pro Gly Ala 
    1340                 1345                 1350             


Glu Leu  Val Lys Pro Gly Ala  Ser Val Lys Met Ser  Cys Lys Ala 
    1355                 1360                 1365             


Ser Gly  Tyr Thr Phe Thr Ser  Tyr Asn Met His Trp  Val Lys Gln 
    1370                 1375                 1380             


Thr Pro  Gly Arg Gly Leu Glu  Trp Ile Gly Ala Ile  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Gly  Asp Thr Ser Tyr Asn  Gln Lys Phe Lys Gly  Lys Ala Thr 
    1400                 1405                 1410             


Leu Thr  Ala Asp Lys Ser Ser  Ser Thr Ala Tyr Met  Gln Leu Ser 
    1415                 1420                 1425             


Ser Leu  Thr Ser Glu Asp Ser  Ala Val Tyr Tyr Cys  Ala Arg Ser 
    1430                 1435                 1440             


Thr Tyr  Tyr Gly Gly Asp Trp  Tyr Phe Asn Val Trp  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Val Thr Val Ser Ser  Ala Ala Ala Thr Gly  Thr Thr Thr 
    1460                 1465                 1470             


Pro Ala  Pro Arg Pro Pro Thr  Pro Ala Pro Thr Ile  Ala Ser Gln 
    1475                 1480                 1485             


Pro Leu  Ser Leu Arg Pro Glu  Ala Cys Arg Pro Ala  Ala Gly Gly 
    1490                 1495                 1500             


Ala Val  His Thr Arg Gly Leu  Asp Phe Ala Cys Asp  Ile Tyr Ile 
    1505                 1510                 1515             


Trp Ala  Pro Leu Ala Gly Thr  Cys Gly Val Leu Leu  Leu Ser Leu 
    1520                 1525                 1530             


Val Ile  Thr Leu Tyr Cys Ala  Leu Tyr Leu Leu Arg  Arg Asp Gln 
    1535                 1540                 1545             


Arg Leu  Pro Pro Asp Ala His  Lys Pro Pro Gly Gly  Gly Ser Phe 
    1550                 1555                 1560             


Arg Thr  Pro Ile Gln Glu Glu  Gln Ala Asp Ala His  Ser Thr Leu 
    1565                 1570                 1575             


Ala Lys  Ile 
    1580     


<210> 76
<211> 654
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 76
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
        35                  40                  45              


Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr 
65                  70                  75                  80  


Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile 
                85                  90                  95      


Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr 
        115                 120                 125             


Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
145                 150                 155                 160 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                165                 170                 175     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            180                 185                 190         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        195                 200                 205             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    210                 215                 220                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
225                 230                 235                 240 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                245                 250                 255     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            260                 265                 270         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        275                 280                 285             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    290                 295                 300                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
305                 310                 315                 320 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                325                 330                 335     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            340                 345                 350         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        355                 360                 365             


Pro Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser 
    370                 375                 380                 


Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
385                 390                 395                 400 


Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                405                 410                 415     


Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu 
            420                 425                 430         


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
        435                 440                 445             


Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp 
    450                 455                 460                 


Ser Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
465                 470                 475                 480 


Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser 
                485                 490                 495     


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
            500                 505                 510         


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser 
        515                 520                 525             


Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn 
    530                 535                 540                 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
545                 550                 555                 560 


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
                565                 570                 575     


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Pro Ile Lys Thr Asp 
            580                 585                 590         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        595                 600                 605             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    610                 615                 620                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
625                 630                 635                 640 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                645                 650                 


<210> 77
<211> 642
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 77
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr 
                245                 250                 255     


Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile 
            260                 265                 270         


Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu 
        275                 280                 285             


Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala 
    290                 295                 300                 


Lys Leu Phe Phe Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
            340                 345                 350         


Leu Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser 
        355                 360                 365             


Pro Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    370                 375                 380                 


Gln Ala Ser His Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
385                 390                 395                 400 


Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln 
                405                 410                 415     


Thr Gly Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe 
            420                 425                 430         


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
        435                 440                 445             


Cys Gln Gln Tyr Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg 
    450                 455                 460                 


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
465                 470                 475                 480 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                485                 490                 495     


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            500                 505                 510         


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        515                 520                 525             


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
    530                 535                 540                 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
545                 550                 555                 560 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro 
                565                 570                 575     


Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys 
            580                 585                 590         


Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr 
        595                 600                 605             


Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile 
    610                 615                 620                 


Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu 
625                 630                 635                 640 


Lys Ser 
        


<210> 78
<211> 894
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 78
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
385                 390                 395                 400 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                405                 410                 415     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            420                 425                 430         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        435                 440                 445             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    450                 455                 460                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
465                 470                 475                 480 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Glu Val Lys 
                485                 490                 495     


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
            500                 505                 510         


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
        515                 520                 525             


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
    530                 535                 540                 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
545                 550                 555                 560 


Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
                565                 570                 575     


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            580                 585                 590         


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
        595                 600                 605             


Pro Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    610                 615                 620                 


Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His 
625                 630                 635                 640 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                645                 650                 655     


Pro Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro 
            660                 665                 670         


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        675                 680                 685             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    690                 695                 700                 


Asp Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
705                 710                 715                 720 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                725                 730                 735     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            740                 745                 750         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        755                 760                 765             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    770                 775                 780                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
785                 790                 795                 800 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                805                 810                 815     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Ile Lys Thr Asp 
            820                 825                 830         


Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp 
        835                 840                 845             


Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
    850                 855                 860                 


Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys 
865                 870                 875                 880 


Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                885                 890                 


<210> 79
<211> 644
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 79
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe 
        115                 120                 125             


Asn Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro 
                245                 250                 255     


Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro 
            260                 265                 270         


Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val 
        275                 280                 285             


Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu 
    290                 295                 300                 


Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys Arg Ser Gly Ser Gly 
305                 310                 315                 320 


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
                325                 330                 335     


Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu 
            340                 345                 350         


Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr Gly Gln Ile Val Leu 
        355                 360                 365             


Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr 
    370                 375                 380                 


Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln 
385                 390                 395                 400 


Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn 
                405                 410                 415     


Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            420                 425                 430         


Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr 
        435                 440                 445             


Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly 
    450                 455                 460                 


Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
465                 470                 475                 480 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                485                 490                 495     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            500                 505                 510         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        515                 520                 525             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    530                 535                 540                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
545                 550                 555                 560 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                565                 570                 575     


Cys Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys 
            580                 585                 590         


Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser 
        595                 600                 605             


Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe 
    610                 615                 620                 


Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn 
625                 630                 635                 640 


Gly Glu Lys Ser 
                


<210> 80
<211> 666
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 80
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe 
        115                 120                 125             


Asn Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro 
                245                 250                 255     


Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro 
            260                 265                 270         


Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val 
        275                 280                 285             


Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu 
    290                 295                 300                 


Leu Thr Ala Lys Leu Phe Phe Leu Arg Ala Lys Arg Ser Gly Ser Gly 
305                 310                 315                 320 


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
                325                 330                 335     


Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu 
            340                 345                 350         


Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr Gly Gln Ile Val Leu 
        355                 360                 365             


Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr 
    370                 375                 380                 


Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln 
385                 390                 395                 400 


Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn 
                405                 410                 415     


Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            420                 425                 430         


Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr 
        435                 440                 445             


Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly 
    450                 455                 460                 


Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
465                 470                 475                 480 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                485                 490                 495     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            500                 505                 510         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        515                 520                 525             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    530                 535                 540                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
545                 550                 555                 560 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                565                 570                 575     


Cys Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys 
            580                 585                 590         


Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser 
        595                 600                 605             


Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe 
    610                 615                 620                 


Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn 
625                 630                 635                 640 


Gly Glu Lys Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His 
                645                 650                 655     


Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
            660                 665     


<210> 81
<211> 381
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 81
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Pro 
        275                 280                 285             


Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala 
    290                 295                 300                 


Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu Ala Leu 
305                 310                 315                 320 


Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe 
                325                 330                 335     


Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380     


<210> 82
<211> 371
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 82
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val 
        275                 280                 285             


Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile 
    290                 295                 300                 


Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe 
305                 310                 315                 320 


Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu 
    370     


<210> 83
<211> 406
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 83
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Pro 
        275                 280                 285             


Thr His Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly 
    290                 295                 300                 


His Met Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu 
305                 310                 315                 320 


Ser Thr His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile 
                325                 330                 335     


Arg Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala 
            340                 345                 350         


Gly Ala Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly 
        355                 360                 365             


Glu Ser Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg 
    370                 375                 380                 


Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro 
385                 390                 395                 400 


Glu Pro Ala Cys Ser Pro 
                405     


<210> 84
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 84
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Pro Thr His Leu Pro Tyr Val Ser Glu Met Leu 
        275                 280                 285             


Glu Ala Arg Thr Ala Gly His Met Gln Thr Leu Ala Asp Phe Arg Gln 
    290                 295                 300                 


Leu Pro Ala Arg Thr Leu Ser Thr His Trp Pro Pro Gln Arg Ser Leu 
305                 310                 315                 320 


Cys Ser Ser Asp Phe Ile Arg Ile Leu Val Ile Phe Ser Gly Met Phe 
                325                 330                 335     


Leu Val Phe Thr Leu Ala Gly Ala Leu Phe Leu His Gln Arg Arg Lys 
            340                 345                 350         


Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys 
        355                 360                 365             


Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln 
    370                 375                 380                 


Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
385                 390                 395     


<210> 85
<211> 557
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 85
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Ala 
        275                 280                 285             


Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn Pro Thr Pro Glu Asn Gly 
    290                 295                 300                 


Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln Ser Leu Leu Val Asp Ser 
305                 310                 315                 320 


Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr Ser Ala Pro Val Ala Leu 
                325                 330                 335     


Ser Ser Thr Gly Lys Pro Val Leu Asp Ala Gly Pro Val Leu Phe Trp 
            340                 345                 350         


Val Ile Leu Val Leu Val Val Val Val Gly Ser Ser Ala Phe Leu Leu 
        355                 360                 365             


Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu 
    370                 375                 380                 


Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser 
385                 390                 395                 400 


Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr 
                405                 410                 415     


Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu 
            420                 425                 430         


Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln 
        435                 440                 445             


Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu 
    450                 455                 460                 


Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr 
465                 470                 475                 480 


Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu 
                485                 490                 495     


Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu 
            500                 505                 510         


Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu 
        515                 520                 525             


Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu 
    530                 535                 540                 


Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
545                 550                 555         


<210> 86
<211> 547
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 86
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
        275                 280                 285             


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
    290                 295                 300                 


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
305                 310                 315                 320 


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
                325                 330                 335     


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
            340                 345                 350         


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
        355                 360                 365             


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
    370                 375                 380                 


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
385                 390                 395                 400 


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
                405                 410                 415     


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
            420                 425                 430         


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
        435                 440                 445             


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
    450                 455                 460                 


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
465                 470                 475                 480 


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
                485                 490                 495     


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
            500                 505                 510         


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
        515                 520                 525             


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
    530                 535                 540                 


Ser Gly Lys 
545         


<210> 87
<211> 397
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 87
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Asp 
        275                 280                 285             


Arg Asp Pro Pro Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala 
    290                 295                 300                 


Arg Pro Ile Thr Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln 
305                 310                 315                 320 


Gly Pro Ser Thr Arg Pro Val Glu Val Pro Gly Gly Arg Ala Val Ala 
                325                 330                 335     


Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro Leu Ala 
            340                 345                 350         


Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro 
        355                 360                 365             


Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
    370                 375                 380                 


Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
385                 390                 395         


<210> 88
<211> 387
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 88
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Asp Arg Asp Pro Pro Ala Thr Gln Pro Gln Glu 
        275                 280                 285             


Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr Glu Ala 
    290                 295                 300                 


Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu Val Pro 
305                 310                 315                 320 


Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly 
                325                 330                 335     


Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg 
            340                 345                 350         


Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser 
        355                 360                 365             


Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu 
    370                 375                 380                 


Ala Lys Ile 
385         


<210> 89
<211> 404
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 89
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                325                 330                 335     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            340                 345                 350         


Thr Leu Tyr Cys Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
        355                 360                 365             


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
    370                 375                 380                 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
385                 390                 395                 400 


Ala Cys Ser Pro 
                


<210> 90
<211> 394
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 90
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        275                 280                 285             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
    290                 295                 300                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
305                 310                 315                 320 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
                325                 330                 335     


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Gln Arg Arg Lys Tyr Arg 
            340                 345                 350         


Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr 
        355                 360                 365             


Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp 
    370                 375                 380                 


Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
385                 390                 


<210> 91
<211> 544
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 91
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                325                 330                 335     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            340                 345                 350         


Thr Leu Tyr Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys 
        355                 360                 365             


Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu 
    370                 375                 380                 


Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala 
385                 390                 395                 400 


Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro 
                405                 410                 415     


Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu 
            420                 425                 430         


Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp 
        435                 440                 445             


Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu 
    450                 455                 460                 


Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys 
465                 470                 475                 480 


Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu 
                485                 490                 495     


Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln 
            500                 505                 510         


Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val 
        515                 520                 525             


Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
    530                 535                 540                 


<210> 92
<211> 534
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 92
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        275                 280                 285             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
    290                 295                 300                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
305                 310                 315                 320 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
                325                 330                 335     


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys His Arg Arg Ala Cys Arg 
            340                 345                 350         


Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser 
        355                 360                 365             


Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr 
    370                 375                 380                 


Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg 
385                 390                 395                 400 


Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala 
                405                 410                 415     


Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly 
            420                 425                 430         


Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His 
        435                 440                 445             


Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val 
    450                 455                 460                 


Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala 
465                 470                 475                 480 


Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr 
                485                 490                 495     


Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser 
            500                 505                 510         


Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro 
        515                 520                 525             


Thr Ala Ala Ser Gly Lys 
    530                 


<210> 93
<211> 398
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 93
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                325                 330                 335     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            340                 345                 350         


Thr Leu Tyr Cys Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro 
        355                 360                 365             


Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile 
    370                 375                 380                 


Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
385                 390                 395             


<210> 94
<211> 388
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 94
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        275                 280                 285             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
    290                 295                 300                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
305                 310                 315                 320 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
                325                 330                 335     


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Ala Leu Tyr Leu Leu Arg 
            340                 345                 350         


Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly 
        355                 360                 365             


Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr 
    370                 375                 380                 


Leu Ala Lys Ile 
385             


<210> 95
<211> 406
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 95
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu Glu 
        275                 280                 285             


Asp Leu Ala Ala Ala Thr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro 
    290                 295                 300                 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
305                 310                 315                 320 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
                325                 330                 335     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            340                 345                 350         


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Ala Leu Tyr Leu 
        355                 360                 365             


Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly 
    370                 375                 380                 


Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His 
385                 390                 395                 400 


Ser Thr Leu Ala Lys Ile 
                405     


<210> 96
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 96
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Thr Gly Thr Thr Thr 
        275                 280                 285             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    290                 295                 300                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
305                 310                 315                 320 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                325                 330                 335     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            340                 345                 350         


Tyr Cys Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp 
        355                 360                 365             


Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
    370                 375                 380                 


Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
385                 390                 395     


<210> 97
<211> 392
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 97
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Ile Glu Val 
        275                 280                 285             


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
    290                 295                 300                 


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
305                 310                 315                 320 


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
                325                 330                 335     


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            340                 345                 350         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        355                 360                 365             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    370                 375                 380                 


Arg Asp Phe Ala Ala Tyr Arg Ser 
385                 390         


<210> 98
<211> 382
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 98
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
        275                 280                 285             


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
    290                 295                 300                 


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    370                 375                 380         


<210> 99
<211> 381
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 99
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Pro 
        275                 280                 285             


Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala 
    290                 295                 300                 


Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu Ala Leu 
305                 310                 315                 320 


Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe 
                325                 330                 335     


Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380     


<210> 100
<211> 371
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 100
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val 
        275                 280                 285             


Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile 
    290                 295                 300                 


Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe 
305                 310                 315                 320 


Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu 
    370     


<210> 101
<211> 406
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 101
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Pro 
        275                 280                 285             


Thr His Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly 
    290                 295                 300                 


His Met Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu 
305                 310                 315                 320 


Ser Thr His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile 
                325                 330                 335     


Arg Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala 
            340                 345                 350         


Gly Ala Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly 
        355                 360                 365             


Glu Ser Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg 
    370                 375                 380                 


Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro 
385                 390                 395                 400 


Glu Pro Ala Cys Ser Pro 
                405     


<210> 102
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 102
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Pro Thr His Leu Pro Tyr Val Ser Glu Met Leu 
        275                 280                 285             


Glu Ala Arg Thr Ala Gly His Met Gln Thr Leu Ala Asp Phe Arg Gln 
    290                 295                 300                 


Leu Pro Ala Arg Thr Leu Ser Thr His Trp Pro Pro Gln Arg Ser Leu 
305                 310                 315                 320 


Cys Ser Ser Asp Phe Ile Arg Ile Leu Val Ile Phe Ser Gly Met Phe 
                325                 330                 335     


Leu Val Phe Thr Leu Ala Gly Ala Leu Phe Leu His Gln Arg Arg Lys 
            340                 345                 350         


Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys 
        355                 360                 365             


Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln 
    370                 375                 380                 


Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
385                 390                 395     


<210> 103
<211> 557
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 103
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Ala 
        275                 280                 285             


Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn Pro Thr Pro Glu Asn Gly 
    290                 295                 300                 


Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln Ser Leu Leu Val Asp Ser 
305                 310                 315                 320 


Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr Ser Ala Pro Val Ala Leu 
                325                 330                 335     


Ser Ser Thr Gly Lys Pro Val Leu Asp Ala Gly Pro Val Leu Phe Trp 
            340                 345                 350         


Val Ile Leu Val Leu Val Val Val Val Gly Ser Ser Ala Phe Leu Leu 
        355                 360                 365             


Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu 
    370                 375                 380                 


Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser 
385                 390                 395                 400 


Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr 
                405                 410                 415     


Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu 
            420                 425                 430         


Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln 
        435                 440                 445             


Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu 
    450                 455                 460                 


Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr 
465                 470                 475                 480 


Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu 
                485                 490                 495     


Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu 
            500                 505                 510         


Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu 
        515                 520                 525             


Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu 
    530                 535                 540                 


Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
545                 550                 555         


<210> 104
<211> 547
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 104
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
        275                 280                 285             


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
    290                 295                 300                 


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
305                 310                 315                 320 


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
                325                 330                 335     


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
            340                 345                 350         


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
        355                 360                 365             


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
    370                 375                 380                 


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
385                 390                 395                 400 


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
                405                 410                 415     


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
            420                 425                 430         


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
        435                 440                 445             


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
    450                 455                 460                 


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
465                 470                 475                 480 


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
                485                 490                 495     


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
            500                 505                 510         


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
        515                 520                 525             


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
    530                 535                 540                 


Ser Gly Lys 
545         


<210> 105
<211> 397
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 105
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Asp 
        275                 280                 285             


Arg Asp Pro Pro Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala 
    290                 295                 300                 


Arg Pro Ile Thr Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln 
305                 310                 315                 320 


Gly Pro Ser Thr Arg Pro Val Glu Val Pro Gly Gly Arg Ala Val Ala 
                325                 330                 335     


Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro Leu Ala 
            340                 345                 350         


Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro 
        355                 360                 365             


Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
    370                 375                 380                 


Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
385                 390                 395         


<210> 106
<211> 387
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 106
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Asp Arg Asp Pro Pro Ala Thr Gln Pro Gln Glu 
        275                 280                 285             


Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr Glu Ala 
    290                 295                 300                 


Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu Val Pro 
305                 310                 315                 320 


Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly 
                325                 330                 335     


Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg 
            340                 345                 350         


Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser 
        355                 360                 365             


Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu 
    370                 375                 380                 


Ala Lys Ile 
385         


<210> 107
<211> 404
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 107
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                325                 330                 335     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            340                 345                 350         


Thr Leu Tyr Cys Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
        355                 360                 365             


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
    370                 375                 380                 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
385                 390                 395                 400 


Ala Cys Ser Pro 
                


<210> 108
<211> 394
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 108
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        275                 280                 285             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
    290                 295                 300                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
305                 310                 315                 320 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
                325                 330                 335     


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Gln Arg Arg Lys Tyr Arg 
            340                 345                 350         


Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr 
        355                 360                 365             


Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp 
    370                 375                 380                 


Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
385                 390                 


<210> 109
<211> 544
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 109
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                325                 330                 335     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            340                 345                 350         


Thr Leu Tyr Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys 
        355                 360                 365             


Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu 
    370                 375                 380                 


Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala 
385                 390                 395                 400 


Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro 
                405                 410                 415     


Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu 
            420                 425                 430         


Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp 
        435                 440                 445             


Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu 
    450                 455                 460                 


Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys 
465                 470                 475                 480 


Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu 
                485                 490                 495     


Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln 
            500                 505                 510         


Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val 
        515                 520                 525             


Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
    530                 535                 540                 


<210> 110
<211> 534
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 110
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        275                 280                 285             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
    290                 295                 300                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
305                 310                 315                 320 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
                325                 330                 335     


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys His Arg Arg Ala Cys Arg 
            340                 345                 350         


Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser 
        355                 360                 365             


Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr 
    370                 375                 380                 


Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg 
385                 390                 395                 400 


Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala 
                405                 410                 415     


Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly 
            420                 425                 430         


Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His 
        435                 440                 445             


Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val 
    450                 455                 460                 


Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala 
465                 470                 475                 480 


Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr 
                485                 490                 495     


Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser 
            500                 505                 510         


Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro 
        515                 520                 525             


Thr Ala Ala Ser Gly Lys 
    530                 


<210> 111
<211> 398
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 111
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                325                 330                 335     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            340                 345                 350         


Thr Leu Tyr Cys Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro 
        355                 360                 365             


Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile 
    370                 375                 380                 


Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
385                 390                 395             


<210> 112
<211> 388
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 112
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Gly Leu Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Thr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        275                 280                 285             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
    290                 295                 300                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
305                 310                 315                 320 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
                325                 330                 335     


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Ala Leu Tyr Leu Leu Arg 
            340                 345                 350         


Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly 
        355                 360                 365             


Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr 
    370                 375                 380                 


Leu Ala Lys Ile 
385             


<210> 113
<211> 387
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 113
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile 
            260                 265                 270         


Ser Glu Glu Asp Leu Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro 
        275                 280                 285             


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
    290                 295                 300                 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
305                 310                 315                 320 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                325                 330                 335     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
            340                 345                 350         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        355                 360                 365             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    370                 375                 380                 


Tyr Arg Ser 
385         


<210> 114
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 114
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Ile Glu 
            260                 265                 270         


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
        275                 280                 285             


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
    290                 295                 300                 


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
305                 310                 315                 320 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    370                 375         


<210> 115
<211> 376
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 115
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile 
            260                 265                 270         


Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Pro Ala Asp Leu Ser Pro 
        275                 280                 285             


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
    290                 295                 300                 


Ser Pro Gln Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu 
305                 310                 315                 320 


Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375     


<210> 116
<211> 366
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 116
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly 
            260                 265                 270         


Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala Pro 
        275                 280                 285             


Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu Ala 
    290                 295                 300                 


Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg 
305                 310                 315                 320 


Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                325                 330                 335     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            340                 345                 350         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        355                 360                 365     


<210> 117
<211> 401
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 117
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile 
            260                 265                 270         


Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Pro Thr His Leu Pro Tyr 
        275                 280                 285             


Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met Gln Thr Leu 
    290                 295                 300                 


Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr His Trp Pro 
305                 310                 315                 320 


Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile Leu Val Ile 
                325                 330                 335     


Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala Leu Phe Leu 
            340                 345                 350         


His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
        355                 360                 365             


Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
    370                 375                 380                 


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
385                 390                 395                 400 


Pro 
    


<210> 118
<211> 391
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 118
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly 
            260                 265                 270         


Pro Thr His Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala 
        275                 280                 285             


Gly His Met Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr 
    290                 295                 300                 


Leu Ser Thr His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe 
305                 310                 315                 320 


Ile Arg Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu 
                325                 330                 335     


Ala Gly Ala Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys 
            340                 345                 350         


Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro 
        355                 360                 365             


Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys 
    370                 375                 380                 


Pro Glu Pro Ala Cys Ser Pro 
385                 390     


<210> 119
<211> 552
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 119
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile 
            260                 265                 270         


Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Ala Pro Pro Leu Gly Thr 
        275                 280                 285             


Gln Pro Asp Cys Asn Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser 
    290                 295                 300                 


Thr Ser Pro Thr Gln Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr 
305                 310                 315                 320 


Leu Pro Ile Pro Thr Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys 
                325                 330                 335     


Pro Val Leu Asp Ala Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu 
            340                 345                 350         


Val Val Val Val Gly Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala 
        355                 360                 365             


Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln 
    370                 375                 380                 


Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser 
385                 390                 395                 400 


Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu 
                405                 410                 415     


Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys His Ser Val 
            420                 425                 430         


Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala 
        435                 440                 445             


Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr 
    450                 455                 460                 


Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp 
465                 470                 475                 480 


Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly 
                485                 490                 495     


Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp 
            500                 505                 510         


His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser 
        515                 520                 525             


Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro 
    530                 535                 540                 


Leu Pro Thr Ala Ala Ser Gly Lys 
545                 550         


<210> 120
<211> 542
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 120
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly 
            260                 265                 270         


Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn Pro Thr Pro Glu Asn 
        275                 280                 285             


Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln Ser Leu Leu Val Asp 
    290                 295                 300                 


Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr Ser Ala Pro Val Ala 
305                 310                 315                 320 


Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala Gly Pro Val Leu Phe 
                325                 330                 335     


Trp Val Ile Leu Val Leu Val Val Val Val Gly Ser Ser Ala Phe Leu 
            340                 345                 350         


Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His 
        355                 360                 365             


Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp 
    370                 375                 380                 


Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val 
385                 390                 395                 400 


Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met 
                405                 410                 415     


Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu 
            420                 425                 430         


Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro 
        435                 440                 445             


Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile 
    450                 455                 460                 


Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu 
465                 470                 475                 480 


Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu 
                485                 490                 495     


Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr 
            500                 505                 510         


Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu 
        515                 520                 525             


Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
    530                 535                 540         


<210> 121
<211> 392
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 121
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile 
            260                 265                 270         


Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Asp Arg Asp Pro Pro Ala 
        275                 280                 285             


Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val 
    290                 295                 300                 


Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg 
305                 310                 315                 320 


Pro Val Glu Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu 
                325                 330                 335     


Gly Leu Val Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu 
            340                 345                 350         


Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
        355                 360                 365             


Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
    370                 375                 380                 


Ala His Ser Thr Leu Ala Lys Ile 
385                 390         


<210> 122
<211> 382
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 122
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly 
            260                 265                 270         


Asp Arg Asp Pro Pro Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro 
        275                 280                 285             


Ala Arg Pro Ile Thr Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser 
    290                 295                 300                 


Gln Gly Pro Ser Thr Arg Pro Val Glu Val Pro Gly Gly Arg Ala Val 
305                 310                 315                 320 


Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro Leu 
                325                 330                 335     


Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro 
            340                 345                 350         


Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile 
        355                 360                 365             


Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
    370                 375                 380         


<210> 123
<211> 399
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 123
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile 
            260                 265                 270         


Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                325                 330                 335     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Gln 
            340                 345                 350         


Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala 
        355                 360                 365             


Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile 
    370                 375                 380                 


Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
385                 390                 395                 


<210> 124
<211> 389
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 124
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu 
            340                 345                 350         


Ser Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu 
        355                 360                 365             


Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu 
    370                 375                 380                 


Pro Ala Cys Ser Pro 
385                 


<210> 125
<211> 539
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 125
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile 
            260                 265                 270         


Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                325                 330                 335     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys His 
            340                 345                 350         


Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr 
        355                 360                 365             


Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro 
    370                 375                 380                 


Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro 
385                 390                 395                 400 


Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys 
                405                 410                 415     


His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala 
            420                 425                 430         


Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg 
        435                 440                 445             


Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met 
    450                 455                 460                 


Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu 
465                 470                 475                 480 


Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu 
                485                 490                 495     


Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro 
            500                 505                 510         


Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys 
        515                 520                 525             


Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
    530                 535                 


<210> 126
<211> 529
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 126
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln 
            340                 345                 350         


Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu 
        355                 360                 365             


Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly 
    370                 375                 380                 


Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln 
385                 390                 395                 400 


Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser 
                405                 410                 415     


Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg 
            420                 425                 430         


Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile 
        435                 440                 445             


Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val 
    450                 455                 460                 


Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro 
465                 470                 475                 480 


Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu 
                485                 490                 495     


Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser 
            500                 505                 510         


Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly 
        515                 520                 525             


Lys 
    


<210> 127
<211> 393
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 127
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile 
            260                 265                 270         


Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                325                 330                 335     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Ala 
            340                 345                 350         


Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys 
        355                 360                 365             


Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
    370                 375                 380                 


Asp Ala His Ser Thr Leu Ala Lys Ile 
385                 390             


<210> 128
<211> 383
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 128
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu 
            340                 345                 350         


Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro 
        355                 360                 365             


Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
    370                 375                 380             


<210> 129
<211> 657
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 129
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
    530                 535                 540                 


Glu Asp Leu Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
545                 550                 555                 560 


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
                565                 570                 575     


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
            580                 585                 590         


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
        595                 600                 605             


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
    610                 615                 620                 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
625                 630                 635                 640 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
                645                 650                 655     


Ser 
    


<210> 130
<211> 647
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 130
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Ile Glu Val Met 
    530                 535                 540                 


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
545                 550                 555                 560 


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
                565                 570                 575     


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            580                 585                 590         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        595                 600                 605             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    610                 615                 620                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
625                 630                 635                 640 


Asp Phe Ala Ala Tyr Arg Ser 
                645         


<210> 131
<211> 646
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 131
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
    530                 535                 540                 


Glu Asp Leu Ala Ala Ala Thr Gly Pro Ala Asp Leu Ser Pro Gly Ala 
545                 550                 555                 560 


Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His Ser Pro 
                565                 570                 575     


Gln Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe 
            580                 585                 590         


Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg 
        595                 600                 605             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    610                 615                 620                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
625                 630                 635                 640 


Glu Gly Gly Cys Glu Leu 
                645     


<210> 132
<211> 636
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 132
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly Pro Ala 
    530                 535                 540                 


Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg 
545                 550                 555                 560 


Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu Ala Leu Thr 
                565                 570                 575     


Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser 
            580                 585                 590         


Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        595                 600                 605             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    610                 615                 620                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
625                 630                 635     


<210> 133
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 133
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
    530                 535                 540                 


Glu Asp Leu Ala Ala Ala Thr Gly Pro Thr His Leu Pro Tyr Val Ser 
545                 550                 555                 560 


Glu Met Leu Glu Ala Arg Thr Ala Gly His Met Gln Thr Leu Ala Asp 
                565                 570                 575     


Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr His Trp Pro Pro Gln 
            580                 585                 590         


Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile Leu Val Ile Phe Ser 
        595                 600                 605             


Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala Leu Phe Leu His Gln 
    610                 615                 620                 


Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala 
625                 630                 635                 640 


Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile 
                645                 650                 655     


Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
            660                 665                 670     


<210> 134
<211> 661
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 134
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly Pro Thr 
    530                 535                 540                 


His Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His 
545                 550                 555                 560 


Met Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser 
                565                 570                 575     


Thr His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg 
            580                 585                 590         


Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly 
        595                 600                 605             


Ala Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu 
    610                 615                 620                 


Ser Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu 
625                 630                 635                 640 


Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu 
                645                 650                 655     


Pro Ala Cys Ser Pro 
            660     


<210> 135
<211> 822
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 135
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
    530                 535                 540                 


Glu Asp Leu Ala Ala Ala Thr Gly Ala Pro Pro Leu Gly Thr Gln Pro 
545                 550                 555                 560 


Asp Cys Asn Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser 
                565                 570                 575     


Pro Thr Gln Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro 
            580                 585                 590         


Ile Pro Thr Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val 
        595                 600                 605             


Leu Asp Ala Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val 
    610                 615                 620                 


Val Val Gly Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg 
625                 630                 635                 640 


Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser 
                645                 650                 655     


Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr 
            660                 665                 670         


Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg 
        675                 680                 685             


Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala 
    690                 695                 700                 


Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly 
705                 710                 715                 720 


Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His 
                725                 730                 735     


Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val 
            740                 745                 750         


Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala 
        755                 760                 765             


Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr 
    770                 775                 780                 


Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser 
785                 790                 795                 800 


Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro 
                805                 810                 815     


Thr Ala Ala Ser Gly Lys 
            820         


<210> 136
<211> 812
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 136
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly Ala Pro 
    530                 535                 540                 


Pro Leu Gly Thr Gln Pro Asp Cys Asn Pro Thr Pro Glu Asn Gly Glu 
545                 550                 555                 560 


Ala Pro Ala Ser Thr Ser Pro Thr Gln Ser Leu Leu Val Asp Ser Gln 
                565                 570                 575     


Ala Ser Lys Thr Leu Pro Ile Pro Thr Ser Ala Pro Val Ala Leu Ser 
            580                 585                 590         


Ser Thr Gly Lys Pro Val Leu Asp Ala Gly Pro Val Leu Phe Trp Val 
        595                 600                 605             


Ile Leu Val Leu Val Val Val Val Gly Ser Ser Ala Phe Leu Leu Cys 
    610                 615                 620                 


His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys 
625                 630                 635                 640 


Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg 
                645                 650                 655     


Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu 
            660                 665                 670         


Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr 
        675                 680                 685             


Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp 
    690                 695                 700                 


Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro 
705                 710                 715                 720 


Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile 
                725                 730                 735     


Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro 
            740                 745                 750         


Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu 
        755                 760                 765             


Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro 
    770                 775                 780                 


Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly 
785                 790                 795                 800 


Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
                805                 810         


<210> 137
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 137
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
    530                 535                 540                 


Glu Asp Leu Ala Ala Ala Thr Gly Asp Arg Asp Pro Pro Ala Thr Gln 
545                 550                 555                 560 


Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro 
                565                 570                 575     


Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val 
            580                 585                 590         


Glu Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu 
        595                 600                 605             


Val Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu 
    610                 615                 620                 


Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly 
625                 630                 635                 640 


Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His 
                645                 650                 655     


Ser Thr Leu Ala Lys Ile 
            660         


<210> 138
<211> 652
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 138
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly Asp Arg 
    530                 535                 540                 


Asp Pro Pro Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg 
545                 550                 555                 560 


Pro Ile Thr Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly 
                565                 570                 575     


Pro Ser Thr Arg Pro Val Glu Val Pro Gly Gly Arg Ala Val Ala Ala 
            580                 585                 590         


Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro Leu Ala Ile 
        595                 600                 605             


Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp 
    610                 615                 620                 


Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
625                 630                 635                 640 


Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                645                 650         


<210> 139
<211> 669
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 139
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
    530                 535                 540                 


Glu Asp Leu Ala Ala Ala Thr Gly Thr Thr Thr Pro Ala Pro Arg Pro 
545                 550                 555                 560 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                565                 570                 575     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            580                 585                 590         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        595                 600                 605             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Gln Arg Arg 
    610                 615                 620                 


Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro 
625                 630                 635                 640 


Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile 
                645                 650                 655     


Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
            660                 665                 


<210> 140
<211> 659
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 140
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly Thr Thr 
    530                 535                 540                 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
545                 550                 555                 560 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
                565                 570                 575     


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
            580                 585                 590         


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        595                 600                 605             


Leu Tyr Cys Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro 
    610                 615                 620                 


Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu 
625                 630                 635                 640 


Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala 
                645                 650                 655     


Cys Ser Pro 
            


<210> 141
<211> 809
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 141
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
    530                 535                 540                 


Glu Asp Leu Ala Ala Ala Thr Gly Thr Thr Thr Pro Ala Pro Arg Pro 
545                 550                 555                 560 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                565                 570                 575     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            580                 585                 590         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        595                 600                 605             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys His Arg Arg 
    610                 615                 620                 


Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr Pro Val 
625                 630                 635                 640 


Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro Arg Arg 
                645                 650                 655     


Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro Val Ala 
            660                 665                 670         


Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys His Ser 
        675                 680                 685             


Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro 
    690                 695                 700                 


Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg Val Ser 
705                 710                 715                 720 


Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala 
                725                 730                 735     


Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu Gly Arg 
            740                 745                 750         


Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala 
        755                 760                 765             


Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly 
    770                 775                 780                 


Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys Glu Asp 
785                 790                 795                 800 


Pro Leu Pro Thr Ala Ala Ser Gly Lys 
                805                 


<210> 142
<211> 799
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 142
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly Thr Thr 
    530                 535                 540                 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
545                 550                 555                 560 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
                565                 570                 575     


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
            580                 585                 590         


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        595                 600                 605             


Leu Tyr Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu 
    610                 615                 620                 


His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val 
625                 630                 635                 640 


Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser 
                645                 650                 655     


Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu 
            660                 665                 670         


Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro 
        675                 680                 685             


Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu 
    690                 695                 700                 


Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala 
                725                 730                 735     


Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu 
            740                 745                 750         


Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu 
        755                 760                 765             


Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu 
    770                 775                 780                 


Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
785                 790                 795                 


<210> 143
<211> 663
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 143
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
    530                 535                 540                 


Glu Asp Leu Ala Ala Ala Thr Gly Thr Thr Thr Pro Ala Pro Arg Pro 
545                 550                 555                 560 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                565                 570                 575     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            580                 585                 590         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        595                 600                 605             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Ala Leu Tyr 
    610                 615                 620                 


Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro 
625                 630                 635                 640 


Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala 
                645                 650                 655     


His Ser Thr Leu Ala Lys Ile 
            660             


<210> 144
<211> 653
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 144
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
        35                  40                  45              


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
            100                 105                 110         


Ser Ser Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
        195                 200                 205             


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly 
                245                 250                 255     


Met Tyr Pro Arg Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    290                 295                 300                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
305                 310                 315                 320 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                325                 330                 335     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        355                 360                 365             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    370                 375                 380                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
                405                 410                 415     


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            420                 425                 430         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        435                 440                 445             


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
    450                 455                 460                 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
465                 470                 475                 480 


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
                485                 490                 495     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
        515                 520                 525             


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Thr Gly Thr Thr 
    530                 535                 540                 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
545                 550                 555                 560 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
                565                 570                 575     


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
            580                 585                 590         


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        595                 600                 605             


Leu Tyr Cys Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro 
    610                 615                 620                 


Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
625                 630                 635                 640 


Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                645                 650             


<210> 145
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 145
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210> 146
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 146
Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210> 147
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 147
Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly 
1               5                   10                  15      


Ala Leu Phe Leu His 
            20      


<210> 148
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 148
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210> 149
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 149
Pro Val Leu Asp Ala Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu 
1               5                   10                  15      


Val Val Val Val Gly Ser Ser Ala Phe Leu Leu Cys 
            20                  25              


<210> 150
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 150
Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu 
            20      


<210> 151
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 151
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210> 152
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 152
Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210> 153
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 153
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210> 154
<211> 188
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 154
His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys 
1               5                   10                  15      


Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg 
            20                  25                  30          


Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu 
        35                  40                  45              


Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr 
    50                  55                  60                  


Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp 
65                  70                  75                  80  


Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro 
                85                  90                  95      


Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile 
            100                 105                 110         


Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro 
        115                 120                 125             


Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu 
    130                 135                 140                 


Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro 
145                 150                 155                 160 


Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly 
                165                 170                 175     


Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185             


<210> 155
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 155
Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210> 156
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 156
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Ile Glu Val 
1               5                   10                  15      


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
            20                  25                  30          


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
        35                  40                  45              


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
    50                  55                  60                  


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
65                  70                  75                  80  


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
                85                  90                  95      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            100                 105                 110         


Arg Asp Phe Ala Ala Tyr Arg Ser 
        115                 120 


<210> 157
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 157
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105         


<210> 158
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 158
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Pro 
1               5                   10                  15      


Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala 
            20                  25                  30          


Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu Ala Leu 
        35                  40                  45              


Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe 
    50                  55                  60                  


Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
65                  70                  75                  80  


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                85                  90                  95      


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            100                 105                 


<210> 159
<211> 94
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 159
Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala Pro 
1               5                   10                  15      


Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu Ala 
            20                  25                  30          


Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg 
        35                  40                  45              


Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    50                  55                  60                  


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
65                  70                  75                  80  


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                85                  90                  


<210> 160
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 160
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Pro 
1               5                   10                  15      


Thr His Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly 
            20                  25                  30          


His Met Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu 
        35                  40                  45              


Ser Thr His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile 
    50                  55                  60                  


Arg Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala 
65                  70                  75                  80  


Gly Ala Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly 
                85                  90                  95      


Glu Ser Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg 
            100                 105                 110         


Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro 
        115                 120                 125             


Glu Pro Ala Cys Ser Pro 
    130                 


<210> 161
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 161
Pro Thr His Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala 
1               5                   10                  15      


Gly His Met Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr 
            20                  25                  30          


Leu Ser Thr His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe 
        35                  40                  45              


Ile Arg Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu 
    50                  55                  60                  


Ala Gly Ala Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys 
65                  70                  75                  80  


Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro 
                85                  90                  95      


Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys 
            100                 105                 110         


Pro Glu Pro Ala Cys Ser Pro 
        115                 


<210> 162
<211> 285
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 162
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Ala 
1               5                   10                  15      


Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn Pro Thr Pro Glu Asn Gly 
            20                  25                  30          


Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln Ser Leu Leu Val Asp Ser 
        35                  40                  45              


Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr Ser Ala Pro Val Ala Leu 
    50                  55                  60                  


Ser Ser Thr Gly Lys Pro Val Leu Asp Ala Gly Pro Val Leu Phe Trp 
65                  70                  75                  80  


Val Ile Leu Val Leu Val Val Val Val Gly Ser Ser Ala Phe Leu Leu 
                85                  90                  95      


Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu 
            100                 105                 110         


Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser 
        115                 120                 125             


Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr 
    130                 135                 140                 


Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu 
145                 150                 155                 160 


Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln 
                165                 170                 175     


Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu 
            180                 185                 190         


Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr 
        195                 200                 205             


Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu 
    210                 215                 220                 


Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu 
225                 230                 235                 240 


Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu 
                245                 250                 255     


Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu 
            260                 265                 270         


Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
        275                 280                 285 


<210> 163
<211> 270
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 163
Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn Pro Thr Pro Glu Asn 
1               5                   10                  15      


Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln Ser Leu Leu Val Asp 
            20                  25                  30          


Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr Ser Ala Pro Val Ala 
        35                  40                  45              


Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala Gly Pro Val Leu Phe 
    50                  55                  60                  


Trp Val Ile Leu Val Leu Val Val Val Val Gly Ser Ser Ala Phe Leu 
65                  70                  75                  80  


Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His 
                85                  90                  95      


Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp 
            100                 105                 110         


Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val 
        115                 120                 125             


Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met 
    130                 135                 140                 


Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu 
145                 150                 155                 160 


Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro 
                165                 170                 175     


Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile 
            180                 185                 190         


Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu 
        195                 200                 205             


Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu 
    210                 215                 220                 


Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr 
225                 230                 235                 240 


Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu 
                245                 250                 255     


Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            260                 265                 270 


<210> 164
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 164
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Asp 
1               5                   10                  15      


Arg Asp Pro Pro Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala 
            20                  25                  30          


Arg Pro Ile Thr Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln 
        35                  40                  45              


Gly Pro Ser Thr Arg Pro Val Glu Val Pro Gly Gly Arg Ala Val Ala 
    50                  55                  60                  


Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro Leu Ala 
65                  70                  75                  80  


Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro 
                85                  90                  95      


Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
            100                 105                 110         


Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        115                 120                 125 


<210> 165
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 165
Asp Arg Asp Pro Pro Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro 
1               5                   10                  15      


Ala Arg Pro Ile Thr Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser 
            20                  25                  30          


Gln Gly Pro Ser Thr Arg Pro Val Glu Val Pro Gly Gly Arg Ala Val 
        35                  40                  45              


Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro Leu 
    50                  55                  60                  


Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro 
65                  70                  75                  80  


Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile 
                85                  90                  95      


Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
            100                 105                 110 


<210> 166
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 166
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Thr 
1               5                   10                  15      


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
            20                  25                  30          


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
        35                  40                  45              


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
    50                  55                  60                  


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
65                  70                  75                  80  


Thr Leu Tyr Cys Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
                85                  90                  95      


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
            100                 105                 110         


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
        115                 120                 125             


Ala Cys Ser Pro 
    130         


<210> 167
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 167
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu 
65                  70                  75                  80  


Ser Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu 
                85                  90                  95      


Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu 
            100                 105                 110         


Pro Ala Cys Ser Pro 
        115         


<210> 168
<211> 272
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 168
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Thr 
1               5                   10                  15      


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
            20                  25                  30          


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
        35                  40                  45              


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
    50                  55                  60                  


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
65                  70                  75                  80  


Thr Leu Tyr Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys 
                85                  90                  95      


Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu 
            100                 105                 110         


Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala 
        115                 120                 125             


Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro 
    130                 135                 140                 


Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu 
145                 150                 155                 160 


Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp 
                165                 170                 175     


Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu 
            180                 185                 190         


Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys 
        195                 200                 205             


Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu 
    210                 215                 220                 


Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln 
225                 230                 235                 240 


Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val 
                245                 250                 255     


Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            260                 265                 270         


<210> 169
<211> 257
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 169
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln 
65                  70                  75                  80  


Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu 
                85                  90                  95      


Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly 
            100                 105                 110         


Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln 
        115                 120                 125             


Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser 
    130                 135                 140                 


Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg 
145                 150                 155                 160 


Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile 
                165                 170                 175     


Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val 
            180                 185                 190         


Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro 
        195                 200                 205             


Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu 
    210                 215                 220                 


Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser 
225                 230                 235                 240 


Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly 
                245                 250                 255     


Lys 
    


<210> 170
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 170
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Thr 
1               5                   10                  15      


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
            20                  25                  30          


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
        35                  40                  45              


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
    50                  55                  60                  


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
65                  70                  75                  80  


Thr Leu Tyr Cys Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro 
                85                  90                  95      


Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile 
            100                 105                 110         


Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        115                 120                 125     


<210> 171
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 171
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu 
65                  70                  75                  80  


Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro 
                85                  90                  95      


Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
            100                 105                 110     


<210> 172
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 172
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Ala Thr Gly Thr 
1               5                   10                  15      


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
            20                  25                  30          


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
        35                  40                  45              


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
    50                  55                  60                  


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
65                  70                  75                  80  


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                85                  90                  95      


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            100                 105                 110         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        115                 120                 125     


<210> 173
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 173
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
65                  70                  75                  80  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                85                  90                  95      


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            100                 105                 110     


<210> 174
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 174
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg Ser Asn 
            100                 105                 110         


Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 175
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 175
Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Tyr 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210> 176
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 176
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 177
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 177
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Gly Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210> 178
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 178
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 179
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 179
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210> 180
<211> 103
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 180
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys 
            100             


<210> 181
<211> 103
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 181
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Glu 
    50                  55                  60                  


Leu Val Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys 
            100             


<210> 182
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 182
Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210> 183
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 183
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210> 184
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 184
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Leu Ser Ser Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210> 185
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 185
Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Tyr 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
        115                 120                 125             


Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
    130                 135                 140                 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
145                 150                 155                 160 


Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro 
            180                 185                 190         


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
        195                 200                 205             


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg 
225                 230                 235                 240 


Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val 
                245                 250                 255     


Thr Val Ser Ser 
            260 


<210> 186
<211> 247
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 186
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Gly Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Ser Arg Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Met 
        115                 120                 125             


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 
145                 150                 155                 160 


Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210> 187
<211> 247
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 187
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 
    130                 135                 140                 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 
145                 150                 155                 160 


His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala 
                165                 170                 175     


Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
        195                 200                 205             


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser 
                245         


<210> 188
<211> 517
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 188
Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Tyr 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
        115                 120                 125             


Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
    130                 135                 140                 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
145                 150                 155                 160 


Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro 
            180                 185                 190         


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
        195                 200                 205             


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Gln Val Trp Gly Trp Gln Gly Gly Met Tyr Pro Arg 
225                 230                 235                 240 


Ser Asn Trp Trp Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr Leu Val 
                245                 250                 255     


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile 
            260                 265                 270         


Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys 
        275                 280                 285             


Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp 
    290                 295                 300                 


Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr 
305                 310                 315                 320 


Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala 
            340                 345                 350         


Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly 
        355                 360                 365             


Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Arg Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Gln Val Gln Leu 
385                 390                 395                 400 


Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met 
                405                 410                 415     


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp 
            420                 425                 430         


Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr 
        435                 440                 445             


Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
    450                 455                 460                 


Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
465                 470                 475                 480 


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr 
                485                 490                 495     


Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr 
            500                 505                 510         


Val Thr Val Ser Ser 
        515         


<210> 189
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 189
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210> 190
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 190
Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn 
1               5                   10                  15      


Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25                  30          


<210> 191
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 191
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 192
<211> 68
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 192
Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu 
1               5                   10                  15      


Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val 
            20                  25                  30          


His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg 
        35                  40                  45              


Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys 
    50                  55                  60                  


Leu Phe Phe Leu 
65              


<210> 193
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 193
Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser 
1               5                   10                  15      


Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala 
            20                  25                  30          


Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala 
        35                  40                  45              


Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly 
    50                  55                  60                  


Glu Lys Ser 
65          


<210> 194
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 194
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 195
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 195
Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
1               5                   10                  15      


Lys Asp Asp Asp Asp Lys 
            20          


<210> 196
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 196
Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Leu Glu Met Ala 
            20          


<210> 197
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 197
Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Leu Glu Met Ala 
            20      


<210> 198
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 198
Gly Gly Gly Gly Ser 
1               5   


<210> 199
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 199
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 200
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 200
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 201
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 201
Ala Ala Ala Thr Gly 
1               5   


<210> 202
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 202
Ala Ala Ala 
1           


<210> 203
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 203
Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly 
1               5                   10      


<210> 204
<211> 847
<212> PRT
<213> Homo sapiens

<400> 204
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 
                325                 330                 335     


Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 
            340                 345                 350         


Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 
        355                 360                 365             


Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 
    370                 375                 380                 


Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 
385                 390                 395                 400 


Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 
                405                 410                 415     


Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 
            420                 425                 430         


Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 
        435                 440                 445             


Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 
    450                 455                 460                 


Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 
465                 470                 475                 480 


Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 
                485                 490                 495     


Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 
            500                 505                 510         


Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 
        515                 520                 525             


Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 
    530                 535                 540                 


Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 
545                 550                 555                 560 


Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 
                565                 570                 575     


Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 
            580                 585                 590         


Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 
        595                 600                 605             


Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 
    610                 615                 620                 


Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 
625                 630                 635                 640 


Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 
                645                 650                 655     


Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 
            660                 665                 670         


Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 
        675                 680                 685             


Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 
    690                 695                 700                 


Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 
705                 710                 715                 720 


Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 
                725                 730                 735     


Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr 
            740                 745                 750         


Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro 
        755                 760                 765             


Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln 
    770                 775                 780                 


Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His 
785                 790                 795                 800 


Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu 
                805                 810                 815     


Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu 
            820                 825                 830         


Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
        835                 840                 845         


<210> 205
<211> 274
<212> PRT
<213> Homo sapiens

<400> 205
Asp Val Gln Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro 
1               5                   10                  15      


Met Pro Ile Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn 
            20                  25                  30          


Ser Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala 
        35                  40                  45              


Trp Glu Glu Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp 
    50                  55                  60                  


Asp Asn Thr Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp 
65                  70                  75                  80  


Ala Ser Pro Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg 
                85                  90                  95      


Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val 
            100                 105                 110         


Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe 
        115                 120                 125             


Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn 
    130                 135                 140                 


Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val 
145                 150                 155                 160 


Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val 
                165                 170                 175     


Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln 
            180                 185                 190         


Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn 
        195                 200                 205             


Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu 
    210                 215                 220                 


Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His 
225                 230                 235                 240 


Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg 
                245                 250                 255     


Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly 
            260                 265                 270         


Arg Arg 
        


<210> 206
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 206
Ser Ser Asn Ile Gly Asn Asn Tyr 
1               5               


<210> 207
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 207
Glu Asn Asn 
1           


<210> 208
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 208
Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Ala Val 
1               5                   10          


<210> 209
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 209
Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210> 210
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 210
Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210> 211
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 211
Ala Arg Pro Tyr Tyr Asp Asp 
1               5           


<210> 212
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 212
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Gly Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210> 213
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 213
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Asp Asp Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210> 214
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 214
His Asp Ile Arg Asn Tyr 
1               5       


<210> 215
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 215
Ala Ala Ser 
1           


<210> 216
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 216
Gln Gln Tyr Asp Gly Leu Pro Leu Thr 
1               5                   


<210> 217
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 217
Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser 
1               5                   10      


<210> 218
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 218
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Gly Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210> 219
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 219
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 220
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 220
Gly Gly Gly Gly Ser 
1               5   


<210> 221
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 221
Gly Gly Ser Gly 
1               


<210> 222
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 222
Ser Gly Gly Gly 
1               


<210> 223
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 223
Gly Ser Gly Ser 
1               


<210> 224
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 224
Gly Ser Gly Ser Gly Ser 
1               5       


<210> 225
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 225
Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210> 226
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 226
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210> 227
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 227
Gly Gly Ser Gly Gly Ser 
1               5       


<210> 228
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 228
Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210> 229
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 229
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210> 230
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 230
Gly Gly Ser Gly 
1               


<210> 231
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 231
Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210> 232
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 232
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10          


<210> 233
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 233
Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Leu Glu Met Ala 
            20      


<210> 234
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 234
His His His His His His 
1               5       


<210> 235
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 235
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 236
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 236
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
1               5                   10  


<210> 237
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 237
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 238
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 238
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 239
<211> 272
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 239
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Gly Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Leu Glu Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        195                 200                 205             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr Asp Asp Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Thr Ser Gly Gln Ala Gly Gln His His 
                245                 250                 255     


His His His His Gly Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
            260                 265                 270         


<210> 240
<211> 272
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 240
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Gly Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Ser Arg Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Met 
        115                 120                 125             


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 
145                 150                 155                 160 


Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Tyr Gly Ser Ala Ala Trp Met Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Thr Ser Gly Gln Ala Gly Gln His His 
                245                 250                 255     


His His His His Gly Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
            260                 265                 270         


<210> 241
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 241
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Tyr Pro Tyr Asp Val Pro Asp 
1               5                   10                  15      


Tyr Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            20                  25          


<210> 242
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 242
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Tyr Pro Tyr Asp Val Pro 
1               5                   10                  15      


Asp Tyr Ala Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
            20                  25                  30  


<210> 243
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 243
Asp Tyr Lys Asp Asp Asp Asp Lys Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  


<210> 244
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 244
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Gln Lys Leu Ile Ser 
1               5                   10                  15      


Glu Glu Asp Leu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30  


