                         SEQUENCE LISTING

<110>  University of Saskatchewan
 
<120>  METHODS AND USES OF MODULATORS OF ANAPHASE PROMOTING COMPLEX 
       (APC) ACTIVITY FOR TREATING CANCER

<130>  13764-P52925PC01

<150>  PCT/CA2018/050414
<151>  2018-04-04

<150>  US 62/744,272
<151>  2018-10-11

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Asn Gly Ser Ser His Asn Asp Leu Arg Val Arg Arg Leu Thr Leu Ile 
1               5                   10                  15      


Ser Arg Leu Cys 
            20  


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

Asn Gly Ser Ser His Asn Asp Ala Arg Val Arg Arg Leu Thr Leu Ile 
1               5                   10                  15      


Ser Arg Leu Cys 
            20  


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Cys Glu Cys Leu Glu Thr Glu Thr Phe His Pro Ile Thr Arg His Leu 
1               5                   10                  15      


Ile Val Pro Val 
            20  


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Arg Met Pro Gln Trp Trp Gln Trp Met Trp Val 
1               5                   10      


<210>  5
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5

Pro Ser Tyr Asn Thr Ile Lys Tyr His Glu Thr His Gly Gly Arg His 
1               5                   10                  15      


Pro Arg Arg Gln Arg Lys Arg Pro Ile 
            20                  25  


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Gly Ala Leu Lys Glu Val Cys Ile Cys Ile Val Glu Ser Val Gly Gly 
1               5                   10                  15      


Glu Val Phe Ser 
            20  


<210>  7
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Ser Lys Trp Thr Trp Arg Met Cys Met Ser Trp Thr Val Asp Arg Phe 
1               5                   10                  15      


Ala Pro Val Pro Trp Pro 
            20          


<210>  8
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Phe Leu Cys 
1           


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Arg Arg Cys Leu Ser Ile Arg Thr Glu Asn Leu Ala Trp Glu Gly Lys 
1               5                   10                  15      


Phe Leu Arg Val 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Val Arg Gln Lys Ser Asp Lys Glu Tyr Glu Arg Val Leu Gly Leu Gly 
1               5                   10                  15      


Leu Arg Arg Leu 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11

Ser Trp Leu Asn Gly Ser Gly Gly Val Val Leu Trp Leu Phe Ser Asn 
1               5                   10                  15      


Phe Cys Cys Gly 
            20  


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12

Gly Ser Ser His Asn Asp Leu Arg Val Arg Arg Leu Thr 
1               5                   10              


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13

Glu Thr Glu Thr Phe His Pro Ile Thr Arg His Leu Ile Val Pro 
1               5                   10                  15  


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14

Arg Met Pro Gln Trp Trp Gln Trp Met 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15

Pro Val Asn Gly Glu Arg Trp Ala Pro 
1               5                   


<210>  16
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16

Gly Arg Met Leu Met Thr Tyr Leu Met Tyr Phe Met Val Leu Trp Val 
1               5                   10                  15      


Pro Arg Pro Trp Gly Pro Pro Leu 
            20                  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17

Arg Lys Lys Arg Arg Gln Arg Arg Arg Arg 
1               5                   10  


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18

Asn Ala Ser Ser His Asn Asp Leu Arg Val Arg Arg Leu Thr Leu Ile 
1               5                   10                  15      


Ser Arg Leu Cys 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19

Asn Gly Ser Ser His Asn Ala Leu Arg Val Arg Arg Leu Thr Leu Ile 
1               5                   10                  15      


Ser Arg Leu Cys 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20

Asn Gly Ser Ser His Asn Asp Ala Arg Val Arg Arg Leu Thr Leu Ile 
1               5                   10                  15      


Ser Arg Leu Cys 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21

Asn Gly Ser Ser His Asn Asp Leu Arg Ala Arg Arg Leu Thr Leu Ile 
1               5                   10                  15      


Ser Arg Leu Cys 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Asn Gly Ser Ser His Asn Asp Leu Arg Val Arg Ala Leu Thr Leu Ile 
1               5                   10                  15      


Ser Arg Leu Cys 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23

Asn Gly Ser Ser His Asn Asp Leu Arg Val Arg Arg Leu Ala Leu Ile 
1               5                   10                  15      


Ser Arg Leu Cys 
            20  


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Xaa Ser Ser His Xaa Asp Ala Xaa Xaa Xaa Arg Xaa Thr 
1               5                   10              


<210>  25
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25

Gly Ser Ser His Asn Asp Ala Arg Val Arg Arg Leu Thr 
1               5                   10              


<210>  26
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26

Arg Lys Lys Arg Arg Gln Arg Arg Arg Arg Lys Lys Arg Arg Gln Arg 
1               5                   10                  15      


Arg Arg 
        


<210>  27
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29

Thr Ala Leu Asp Trp Ser Trp Leu Gln Thr Glu 
1               5                   10      


<210>  30
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  31
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  31

Ile Ala Ala Arg Ile Lys Leu Arg Ser Arg Gln His Ile Lys Leu Arg 
1               5                   10                  15      


His Leu 
        


<210>  32
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32

Val Leu Glu Leu Ala Gly Asn Ala Ala Lys Asp Leu Lys Val Lys Arg 
1               5                   10                  15      


Ile Thr Pro Arg His Leu Gln Leu Ala Ile Arg 
            20                  25          


<210>  33
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33

Arg Glu Lys Lys Gln Lys Cys Leu Lys Cys Val Arg Arg Leu Ser Leu 
1               5                   10                  15      


Ile Ser Pro Lys Lys Tyr Ile Met Pro 
            20                  25  


<210>  34
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34

Ile His Ser Lys Ser Met Ser Val Glu Arg Gly Ile Arg Trp Glu Leu 
1               5                   10                  15      


Ile Ser Arg Leu Cys Pro Asn Ser Thr Gly Ala 
            20                  25          


<210>  35
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35

Cys Asp Leu Ser Val Val Asp Leu His Ile Arg Arg Leu Thr Pro Gly 
1               5                   10                  15      


Ala Lys Ile Gly 
            20  


<210>  36
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36

Lys Ile Asn Gly Asn Thr Leu Asn Asp Leu Val Ile Lys Arg Leu Leu 
1               5                   10                  15      


Glu Lys Asp Val Thr Leu Arg Ile Ser Ile Gln 
            20                  25          


<210>  37
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic contruct

<400>  37

Ser Phe Pro Leu Gly Val Leu Arg Arg Arg Leu Thr Ile Ser Ser Leu 
1               5                   10                  15      


Thr Ser Phe Gln Pro Thr Thr 
            20              


<210>  38
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38

Val Gly Phe Asp Ala Val Val Asp Val Arg Arg Arg Leu Thr Ile Ser 
1               5                   10                  15      


His Leu Gln Asn Leu Leu Asp Ser 
            20                  


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39

Tyr His Glu Lys Met Pro Lys Trp Ser Gln Trp Val Ala Lys Gly Ser 
1               5                   10                  15      


Ala Ala Tyr Leu 
            20  


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40

Asp Asn Val Thr Thr Gln Trp Arg Glu Trp Met Phe Pro His Asn Glu 
1               5                   10                  15      


Thr 
    


<210>  41
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41

Ser Gln Cys Arg Glu Lys Ser Gln Trp Lys Trp Phe Leu Asn Leu Cys 
1               5                   10                  15      


Tyr Val 
        


<210>  42
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42

Glu Asn Asp Lys Glu Gly Trp Gln Arg Leu Trp Lys Ser Tyr Gln Asp 
1               5                   10                  15      


Phe Tyr 
        


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43

Leu Met Pro Gly Phe Trp Thr Phe Met Trp Lys Leu Ser Pro Tyr Thr 
1               5                   10                  15      


<210>  44
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic contruct

<400>  44

Met Ala Gly Asp Ile Trp Arg Lys Trp Leu Trp Arg Glu Leu Glu Glu 
1               5                   10                  15      


Ser Ser 
        


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45

Val Ser Leu Met Pro Gly Phe Trp Thr Phe Met Trp Lys Ala Ser 
1               5                   10                  15  


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46

Ser Lys Trp Thr 
1               


<210>  47
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Met Cys Met Ser 
1               


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48

Ser Lys Trp Thr Trp Arg Met Cys Met Ser 
1               5                   10  


