                         б

<110>  ϺҫƼ޹˾
       
<120>  LGR4/RSPOϼ뿹߼Ƽ

<130>  P2019-0381

<150>  CN 201810284685.5
<151>  2018-04-02

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  501
<212>  PRT
<213>  (Homo sapiens)

<400>  1

Leu Cys Ala Ala Pro Cys Ser Cys Asp Gly Asp Arg Arg Val Asp Cys 
1               5                   10                  15      


Ser Gly Lys Gly Leu Thr Ala Val Pro Glu Gly Leu Ser Ala Phe Thr 
            20                  25                  30          


Gln Ala Leu Asp Ile Ser Met Asn Asn Ile Thr Gln Leu Pro Glu Asp 
        35                  40                  45              


Ala Phe Lys Asn Phe Pro Phe Leu Glu Glu Leu Gln Leu Ala Gly Asn 
    50                  55                  60                  


Asp Leu Ser Phe Ile His Pro Lys Ala Leu Ser Gly Leu Lys Glu Leu 
65                  70                  75                  80  


Lys Val Leu Thr Leu Gln Asn Asn Gln Leu Lys Thr Val Pro Ser Glu 
                85                  90                  95      


Ala Ile Arg Gly Leu Ser Ala Leu Gln Ser Leu Arg Leu Asp Ala Asn 
            100                 105                 110         


His Ile Thr Ser Val Pro Glu Asp Ser Phe Glu Gly Leu Val Gln Leu 
        115                 120                 125             


Arg His Leu Trp Leu Asp Asp Asn Ile Leu Thr Glu Val Pro Val Arg 
    130                 135                 140                 


Pro Leu Ser Asn Leu Pro Thr Leu Gln Ala Leu Thr Leu Ala Leu Asn 
145                 150                 155                 160 


Asn Ile Ser Ser Ile Pro Asp Phe Ala Phe Thr Asn Leu Ser Ser Leu 
                165                 170                 175     


Val Val Leu His Leu His Asn Asn Lys Ile Lys Ser Leu Ser Gln His 
            180                 185                 190         


Cys Phe Asp Gly Leu Asp Asn Leu Glu Thr Leu Asp Leu Asn Tyr Asn 
        195                 200                 205             


Asn Leu Asp Glu Phe Pro Gln Ala Ile Lys Ala Leu Pro Ser Leu Lys 
    210                 215                 220                 


Glu Leu Gly Phe His Ser Asn Ser Ile Ser Val Ile Pro Asp Gly Ala 
225                 230                 235                 240 


Phe Ala Gly Asn Pro Leu Leu Arg Thr Ile His Leu Tyr Asp Asn Pro 
                245                 250                 255     


Leu Ser Phe Val Gly Asn Ser Ala Phe His Asn Leu Ser Asp Leu His 
            260                 265                 270         


Ser Leu Val Ile Arg Gly Ala Ser Leu Val Gln Trp Phe Pro Asn Leu 
        275                 280                 285             


Ala Gly Thr Val His Leu Glu Ser Leu Thr Leu Thr Gly Thr Lys Ile 
    290                 295                 300                 


Ser Ser Ile Pro Asp Asp Leu Cys Gln Asn Gln Lys Met Leu Arg Thr 
305                 310                 315                 320 


Leu Asp Leu Ser Tyr Asn Asp Ile Arg Asp Leu Pro Ser Phe Asn Gly 
                325                 330                 335     


Cys Arg Ala Leu Glu Glu Ile Ser Leu Gln Arg Asn Gln Ile Ser Leu 
            340                 345                 350         


Ile Lys Glu Thr Thr Phe Gln Gly Leu Thr Ser Leu Arg Ile Leu Asp 
        355                 360                 365             


Leu Ser Arg Asn Leu Ile Arg Glu Ile His Ser Gly Ala Phe Ala Lys 
    370                 375                 380                 


Leu Gly Thr Ile Thr Asn Leu Asp Val Ser Phe Asn Glu Leu Thr Ser 
385                 390                 395                 400 


Phe Pro Thr Glu Gly Leu Asn Gly Leu Asn Gln Leu Lys Leu Val Gly 
                405                 410                 415     


Asn Phe Gln Leu Lys Asp Ala Leu Ala Ala Arg Asp Phe Ala Asn Leu 
            420                 425                 430         


Arg Ser Leu Ser Val Pro Tyr Ala Tyr Gln Cys Cys Ala Phe Trp Gly 
        435                 440                 445             


Cys Asp Ser Tyr Ala Asn Leu Asn Thr Glu Asp Asn Ser Pro Gln Asp 
    450                 455                 460                 


His Ser Val Thr Lys Glu Lys Gly Ala Thr Asp Ala Ala Asn Ala Thr 
465                 470                 475                 480 


Ser Thr Ala Glu Ser Glu Glu His Ser Gln Ile Ile Ile His Cys Thr 
                485                 490                 495     


Pro Ser Thr Gly Ala 
            500     


<210>  2
<211>  1503
<212>  DNA
<213>  (Homo sapiens)

<400>  2
ctctgcgctg cgccctgcag ctgcgacggc gaccgtcggg tggactgctc cgggaagggg       60

ttgacggcgg taccggaggg gctcagcgcc ttcacccaag cactggatat cagtatgaac      120

aatatcactc agttaccaga agatgcattt aagaattttc cttttctaga ggagctacaa      180

ctggctggta acgacctttc ttttatccac ccaaaagcct tgtctgggtt gaaagaactc      240

aaagtcctaa ccctccagaa caatcagttg aaaacagtac ccagtgaagc cattcgtgga      300

ctgagtgctt tgcagtctct acgcttagat gccaaccata ttacctcagt cccggaggac      360

agttttgaag ggctcgttca gttgcggcat ctgtggctgg atgacaacat cttgacggaa      420

gtgcctgtgc gtccgctcag caacctgcca accctgcagg cgctgacctt ggctctcaac      480

aacatctcaa gcatccccga cttcgcattc accaaccttt caagcttggt agtgctgcat      540

cttcataaca ataaaattaa aagcctcagt caacactgtt ttgatggact agataacctg      600

gaaaccctgg acttgaatta taataacttg gatgaatttc ctcaggctat taaagccctt      660

cccagcctta aagagctggg atttcacagt aattctattt ctgttatccc ggatggagca      720

tttgctggta atccactgct aagaactatc catttgtatg ataatcctct gtcttttgtg      780

gggaactcag catttcacaa cctgtctgat ctgcattcct tagtcattcg tggtgcaagc      840

ctggtgcagt ggttccccaa tctggccgga actgtccatc tggagagtct aaccttgaca      900

gggacaaaaa taagcagcat acctgatgat ctgtgccaaa accaaaagat gctgcggact      960

ctggacttat cttataacga tataagagac cttccaagtt ttaatggttg tcgtgcattg     1020

gaagaaattt cattgcagcg taatcaaatc tccctgataa aggaaactac ttttcaaggc     1080

ctaacatccc taaggattct agatctgagt agaaacctga ttcgtgaaat tcacagtgga     1140

gcttttgcga agcttgggac aattactaac ctggatgtga gtttcaatga attaacctca     1200

tttcctacgg aaggcctgaa tgggctcaat caacttaaac ttgtgggtaa cttccagctg     1260

aaagatgcct tggcagccag agactttgcc aatctcaggt ctctatcagt accatatgct     1320

tatcagtgtt gtgcattttg ggggtgtgac tcttatgcaa atttaaacac agaagataac     1380

agcccccaag accacagtgt gacaaaagag aaaggtgcta cagatgcagc aaatgccacc     1440

agcactgctg aaagtgaaga acatagccaa ataatcatcc attgtacacc ttcaacaggt     1500

gct                                                                   1503


