                         SEQUENCE LISTING

<110>  Silence Therapeutics GmbH
 
<120>  siRNAs with vinylphosphonate at the 5' end of the antisense 
       strand

<130>  O34526.00262

<150>  PCT/EP2018/058764 
<151>  5 April 2018

<150>  EP 18197795.0
<151>  28 September 2018

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  1
uuauagagca agaacacugu u                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  2
aacaguguuc uugcucuaua a                                                 21


<210>  3
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  3
uuauagagca agaacacugu u                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  4
aacaguguuc uugcucuaua a                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  5
uuauagagca agaacacugu u                                                 21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  6
aacaguguuc uugcucuaua a                                                 21


<210>  7
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  7
aaccagaaga agcagguga                                                    19


<210>  8
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  8
ucaccugcuu cuucugguu                                                    19


<210>  9
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  9
uaccagaaga agcagguga                                                    19


<210>  10
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  10
ucaccugcuu cuucuggua                                                    19


<210>  11
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  11
uaccagaaga agcagguga                                                    19


<210>  12
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  12
ucaccugcuu cuucuggua                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  13
aauguuuucc ugcugacgg                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  14
ccgucagcag gaaaacauu                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  15
uauguuuucc ugcugacgg                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  16
ccgucagcag gaaaacaua                                                    19


<210>  17
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  17
ucuucuuaaa cugaguuuc                                                    19


<210>  18
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  18
gaaacucagu uuaagaaga                                                    19


<210>  19
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  19
ucuucuuaaa cugaguuuc                                                    19


<210>  20
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  20
gaaacucagu uuaagaaga                                                    19


<210>  21
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  21
ucgaaguauu ccgcguacg                                                    19


<210>  22
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  22
cguacgcgga auacuucga                                                    19


<210>  23
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  23
aaccagaaga agcagguga                                                    19


<210>  24
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  24
ucaccugcuu cuucugguu                                                    19


<210>  25
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  25
uaccagaaga agcagguga                                                    19


<210>  26
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  26
ucaccugcuu cuucuggua                                                    19


<210>  27
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  27
uaccagaaga agcagguga                                                    19


<210>  28
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  28
ucaccugcuu cuucuggua                                                    19


<210>  29
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  29
uaccagaaga agcagguga                                                    19


<210>  30
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  30
ucaccugcuu cuucuggua                                                    19


<210>  31
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  31
ucuucuuaaa cugaguuuc                                                    19


<210>  32
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  32
gaaacucagu uuaagaaga                                                    19


<210>  33
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  33
ucuucuuaaa cugaguuuc                                                    19


<210>  34
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  34
gaaacucagu uuaagaaga                                                    19


<210>  35
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  35
tggacaccaa atcgtactgg aa                                                22


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  36
cagagtcgtt ggctgtgaaa ac                                                22


<210>  37
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe - modified as per summary sequence table at the end of the 
       description

<400>  37
acttggcatt tccccgttcc atgaatt                                           27


<210>  38
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  38
ccgccaaagc ccagaag                                                      17


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  39
ggtccctccc caaaggaata g                                                 21


<210>  40
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe - modified as per summary sequence table at the end of the 
       description

<400>  40
cagcacccgc ctgggaactt actacaac                                          28


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  41
ggcaagcctt atgtcatctc gt                                                22


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  42
ggaatggttt tcccatggta ctt                                               23


<210>  43
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe - modified as per summary sequence table at the end of the 
       description

<400>  43
tgaaatgtct ccgctattac gctggctg                                          28


<210>  44
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  44
aaagaggcca gtcaagctgt tc                                                22


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  45
ggtgggatca cttctgtttt gg                                                22


<210>  46
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe - modified as per summary sequence table at the end of the 
       description

<400>  46
cagcaacaca ctgcatctgg tctctacca                                         29


<210>  47
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  47
caccgccaaa tttaactgca ga                                                22


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  48
aagggtttga taagttctag ctgt                                              24


<210>  49
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe - modified as per summary sequence table at the end of the 
       description

<400>  49
tgcacagtat ccttttgaag accataaccc a                                      31


<210>  50
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  50
aaccagaaga agcagguga                                                    19


<210>  51
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  51
ucaccugcuu cuucugguu                                                    19


<210>  52
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  52
uaccagaaga agcagguga                                                    19


<210>  53
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  53
ucaccugcuu cuucuggua                                                    19


<210>  54
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  54
uaccagaaga agcagguga                                                    19


<210>  55
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  55
ucaccugcuu cuucuggua                                                    19


<210>  56
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  56
uaccagaaga agcagguga                                                    19


<210>  57
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  57
ucaccugcuu cuucuggua                                                    19


<210>  58
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  58
uaccagaaga agcagguga                                                    19


<210>  59
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  59
ucaccugcuu cuucuggua                                                    19


<210>  60
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  60
ucgaaguauu ccgcguacg                                                    19


<210>  61
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - modified_nucleotides, modified as per summary 
       sequence table at the end of the description

<400>  61
cguacgcgga auacuucga                                                    19


<210>  62
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  62
caccgccaaa tttaactgca ga                                                22


<210>  63
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  63
aagggtttga taagttctag ctgt                                              24


<210>  64
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe - modified as per summary sequence table at the end of the 
       description

<400>  64
tgcacagtat ccttttgaag accataaccc a                                      31


<210>  65
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  65
ccgccaaagc ccagaag                                                      17


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  66
ggtccctccc caaaggaata g                                                 21


<210>  67
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe - modified as per summary sequence table at the end of the 
       description

<400>  67
cagcacccgc ctgggaactt actacaac                                          28


<210>  68
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - sequence modified as per summary sequence table at
       the end of the description

<400>  68
uaccagaaga agcagguga                                                    19


<210>  69
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand

<400>  69
ucaccugcuu cuucuggua                                                    19


<210>  70
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - sequence modified as per summary sequence table at
       the end of the description

<400>  70
ucaccugcuu cuucuggua                                                    19


<210>  71
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - sequence modified as per summary sequence table at
       the end of the description

<400>  71
uuauagagca agaacacugu u                                                 21


<210>  72
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand

<400>  72
aacaguguuc uugcucuaua a                                                 21


<210>  73
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - sequence modified as per summary sequence table at
       the end of the description

<400>  73
aacaguguuc uugcucuaua a                                                 21


<210>  74
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - sequence modified as per summary sequence table at
       the end of the description

<400>  74
ucuucuuaaa cugaguuuc                                                    19


<210>  75
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand

<400>  75
gaaacucagu uuaagaaga                                                    19


<210>  76
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - sequence modified as per summary sequence table at
       the end of the description

<400>  76
gaaacucagu uuaagaaga                                                    19


<210>  77
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA strand - sequence modified as per summary sequence table at
       the end of the description

<400>  77
gaaacucagu uuaagaaga                                                    19


