                         SEQUENCE LISTING

<110>  GDANSKI UNIWERSYTET MEDYCZNY
 
<120>  Factor B and C2 Protein Point Mutants, a Method for Enhancing the
        Activity of Anti-Cancer Antibodies, the Pharmaceutical 
       Composition and the Use of Mutants

<130>  1PCT/MM/2019

<140>  PCT/PL2019/000024
<141>  2019-04-03

<150>  P.425133
<151>  2018-04-04

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


<210>  2
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser Ala Pro Ser Cys Pro Gln Asn Val Asn Ile Ser Gly 
            20                  25                  30          


Gly Thr Phe Thr Leu Ser His Gly Trp Ala Pro Gly Ser Leu Leu Thr 
        35                  40                  45              


Tyr Ser Cys Pro Gln Gly Leu Tyr Pro Ser Pro Ala Ser Arg Leu Cys 
    50                  55                  60                  


Lys Ser Ser Gly Gln Trp Gln Thr Pro Gly Ala Thr Arg Ser Leu Ser 
65                  70                  75                  80  


Lys Ala Val Cys Lys Pro Val Arg Cys Pro Ala Pro Val Ser Phe Glu 
                85                  90                  95      


Asn Gly Ile Tyr Thr Pro Arg Leu Gly Ser Tyr Pro Val Gly Gly Asn 
            100                 105                 110         


Val Ser Phe Glu Cys Glu Asp Gly Phe Ile Leu Arg Gly Ser Pro Val 
        115                 120                 125             


Arg Gln Cys Arg Pro Asn Gly Met Trp Asp Gly Glu Thr Ala Val Cys 
    130                 135                 140                 


Asp Asn Gly Ala Gly His Cys Pro Asn Pro Gly Ile Ser Leu Gly Ala 
145                 150                 155                 160 


Val Arg Thr Gly Phe Arg Phe Gly His Gly Asp Lys Val Arg Tyr Arg 
                165                 170                 175     


Cys Ser Ser Asn Leu Val Leu Thr Gly Ser Ser Glu Arg Glu Cys Gln 
            180                 185                 190         


Gly Asn Gly Val Trp Ser Gly Thr Glu Pro Ile Cys Arg Gln Pro Tyr 
        195                 200                 205             


Ser Tyr Asp Phe Pro Glu Asp Val Ala Pro Ala Leu Gly Thr Ser Phe 
    210                 215                 220                 


Ser His Met Leu Gly Ala Thr Asn Pro Thr Gln Lys Thr Lys Glu Ser 
225                 230                 235                 240 


Leu Gly Arg Lys Ile Gln Ile Gln Arg Ser Gly His Leu Asn Leu Tyr 
                245                 250                 255     


Leu Leu Leu Asp Cys Ser Gln Ser Val Ser Glu Asn Asp Phe Leu Ile 
            260                 265                 270         


Phe Lys Glu Ser Ala Ser Leu Met Val Asp Arg Ile Phe Ser Phe Glu 
        275                 280                 285             


Ile Asn Val Ser Val Ala Ile Ile Thr Phe Ala Ser Glu Pro Lys Val 
    290                 295                 300                 


Leu Met Ser Val Leu Asn Asp Asn Ser Arg Asp Met Thr Glu Val Ile 
305                 310                 315                 320 


Ser Ser Leu Glu Asn Ala Asn Tyr Lys Asp His Glu Asn Gly Thr Gly 
                325                 330                 335     


Thr Asn Thr Tyr Ala Ala Leu Asn Ser Val Tyr Leu Met Met Asn Asn 
            340                 345                 350         


Gln Met Arg Leu Leu Gly Met Glu Thr Met Ala Trp Gln Glu Ile Arg 
        355                 360                 365             


His Ala Ile Ile Leu Leu Thr Asp Gly Lys Ser Asn Met Gly Gly Ser 
    370                 375                 380                 


Pro Lys Thr Ala Val Asp His Ile Arg Glu Ile Leu Asn Ile Asn Gln 
385                 390                 395                 400 


Lys Arg Asn Asp Tyr Leu Asp Ile Tyr Ala Ile Gly Val Gly Lys Leu 
                405                 410                 415     


Asp Val Asp Trp Arg Glu Leu Asn Glu Leu Gly Ser Lys Lys Asp Gly 
            420                 425                 430         


Glu Arg His Ala Phe Ile Leu Gln Asp Thr Lys Ala Leu His Gln Val 
        435                 440                 445             


Phe Glu His Met Leu Asp Val Ser Lys Leu Thr Asp Thr Ile Cys Gly 
    450                 455                 460                 


Val Gly Asn Met Ser Ala Asn Ala Ser Asp Gln Glu Arg Thr Pro Trp 
465                 470                 475                 480 


His Val Thr Ile Lys Pro Lys Ser Gln Glu Thr Cys Arg Gly Ala Leu 
                485                 490                 495     


Ile Ser Asp Gln Trp Val Leu Thr Ala Ala His Cys Phe Arg Asp Gly 
            500                 505                 510         


Asn Asp His Ser Leu Trp Arg Val Asn Val Gly Asp Pro Lys Ser Gln 
        515                 520                 525             


Trp Gly Lys Glu Phe Leu Ile Glu Lys Ala Val Ile Ser Pro Gly Phe 
    530                 535                 540                 


Asp Val Phe Ala Lys Lys Asn Gln Gly Ile Leu Glu Phe Tyr Gly Asp 
545                 550                 555                 560 


Asp Ile Ala Leu Leu Lys Leu Ala Gln Lys Val Lys Met Ser Thr His 
                565                 570                 575     


Ala Arg Pro Ile Cys Leu Pro Cys Thr Met Glu Ala Asn Leu Ala Leu 
            580                 585                 590         


Arg Arg Pro Gln Gly Ser Thr Cys Arg Asp His Glu Asn Glu Leu Leu 
        595                 600                 605             


Asn Lys Gln Ser Val Pro Ala His Phe Val Ala Leu Asn Gly Ser Lys 
    610                 615                 620                 


Leu Asn Ile Asn Leu Lys Met Gly Val Glu Trp Thr Ser Cys Ala Glu 
625                 630                 635                 640 


Val Val Ser Gln Glu Lys Thr Met Phe Pro Asn Leu Thr Asp Val Arg 
                645                 650                 655     


Glu Val Val Thr Asp Gln Phe Leu Cys Ser Gly Thr Gln Glu Asp Glu 
            660                 665                 670         


Ser Pro Cys Lys Gly Glu Ser Gly Gly Ala Val Phe Leu Glu Arg Arg 
        675                 680                 685             


Phe Arg Phe Phe Gln Val Gly Leu Val Ser Trp Gly Leu Tyr Asn Pro 
    690                 695                 700                 


Cys Leu Gly Ser Ala Asp Lys Asn Ser Arg Lys Arg Ala Pro Arg Ser 
705                 710                 715                 720 


Lys Val Pro Pro Pro Arg Asp Phe His Ile Asn Leu Phe Arg Met Gln 
                725                 730                 735     


Pro Trp Leu Arg Gln His Leu Gly Asp Val Leu Asn Phe Leu Pro Leu 
            740                 745                 750         


