                         SEQUENCE LISTING

<110>  BRISTOL-MYERS SQUIBB COMPANY
 
<120>  ANTI-TREM-1 ANTIBODIES AND USES THEREOF

<130>  3338.092PC01/ELE/C-K/DKC

<150>  US 62/651,605
<151>  2018-04-02

<160>  84    
<170>  PatentIn version 3.5

<210>  1
<211>  234
<212>  PRT
<213>  homo sapiens

<400>  1

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              


Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  


Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  


Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      


Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         


Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             


Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 


Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 


Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     


Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         


Thr Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn Ile Val Ile 
        195                 200                 205             


Leu Leu Ala Gly Gly Phe Leu Ser Lys Ser Leu Val Phe Ser Val Leu 
    210                 215                 220                 


Phe Ala Val Thr Leu Arg Ser Phe Val Pro 
225                 230                 


<210>  2
<211>  225
<212>  PRT
<213>  homo sapiens

<400>  2

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              


Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  


Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  


Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      


Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         


Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             


Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 


Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 


Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     


Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         


Thr Asn Val Thr Asp Ile Ile Arg Tyr Ser Phe Gln Val Pro Gly Pro 
        195                 200                 205             


Leu Val Trp Thr Leu Ser Pro Leu Phe Pro Ser Leu Cys Ala Glu Arg 
    210                 215                 220                 


Met 
225 


<210>  3
<211>  150
<212>  PRT
<213>  homo sapiens

<400>  3

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              


Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  


Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  


Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      


Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         


Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             


Ile Arg Leu Val Val Thr Lys Gly Phe Arg Cys Ser Thr Leu Ser Phe 
    130                 135                 140                 


Ser Trp Leu Val Asp Ser 
145                 150 


<210>  4
<211>  3333
<212>  DNA
<213>  Homo sapiens

<400>  4
gtgcaacttt ccgaagcctc taggtcattg tggtgccttg tagctgtccc gggagccctc       60

agcagcagtt ggagctggtg cacaggaagg atgaggaaga ccaggctctg ggggctgctg      120

tggatgctct ttgtctcaga actccgagct gcaactaaat taactgagga aaagtatgaa      180

ctgaaagagg ggcagaccct ggatgtgaaa tgtgactaca cgctagagaa gtttgccagc      240

agccagaaag cttggcagat aataagggac ggagagatgc ccaagaccct ggcatgcaca      300

gagaggcctt caaagaattc ccatccagtc caagtgggga ggatcatact agaagactac      360

catgatcatg gtttactgcg cgtccgaatg gtcaaccttc aagtggaaga ttctggactg      420

tatcagtgtg tgatctacca gcctcccaag gagcctcaca tgctgttcga tcgcatccgc      480

ttggtggtga ccaagggttt ttcagggacc cctggctcca atgagaattc tacccagaat      540

gtgtataaga ttcctcctac caccactaag gccttgtgcc cactctatac cagccccaga      600

actgtgaccc aagctccacc caagtcaact gccgatgtct ccactcctga ctctgaaatc      660

aaccttacaa atgtgacaga tatcatcagg gttccggtgt tcaacattgt cattctcctg      720

gctggtggat tcctgagtaa gagcctggtc ttctctgtcc tgtttgctgt cacgctgagg      780

tcatttgtac cctaggccca cgaacccacg agaatgtcct ctgacttcca gccacatcca      840

tctggcagtt gtgccaaggg aggagggagg aggtaaaagg cagggagtta ataacatgaa      900

ttaaatctgt aatcaccggc tatttctaaa gtcagcgtct caccttcctg cccactgccc      960

tcgttcctct aataatcttg ggtgggcatt tgtgcctcag aaaagaagtt acagccccaa     1020

acatgcttgg tccttcattc caccagccac ttggggttgg catgaaatac agacagctca     1080

atgcttttca ccgtaattct cttgtggggg ctgtgacatg cagaaggcac acctgatact     1140

tctcctgctc agttttgccc tggaccatac aattttggcc tgacctggac agagctccca     1200

ctacagaagc atcctgctcg ccccatgctg ggacttcctc tttctagcat cagacacttg     1260

ggtttcatgc ttatgtgtgg ttctttccaa cactcccaga aaagggtgtt gaagattgtg     1320

gaacctggag aaataagaca tcgtggtgag aaagtgcatc cttctcagag aaaagagtta     1380

aactgagtat cttcttctgg ggaaatactg gcaggccgag atgggatcca taggagagca     1440

acaacagacc atgtcagaca tcctgtgtgc atttatcgct ggatcctgaa aatagccccg     1500

tgaaggcaga aatgtatgtg actagaacga ggccacatga ataagccact gcccactggc     1560

aggagtgaaa actgaagcgc tccttacctg aaggacccca aaaccatata gaatagaata     1620

accaggagtt ccgcctgtgt ctaaatgcct cttttcctgt atcacacaag ggtcagggat     1680

ggtggagtaa aagctctccc cctgggaggc ttctggaggc tgtccccatg tgcttgccta     1740

gttccccact ctgccctcct cctcttctct cagtctgctc ctggaacacc tgcctcagtt     1800

tccatgctct ctccagtgcc ctccccggtg aagcaggtag gtgttcaggc caccacagag     1860

acaatctctg tgggagattg tcttgcaatc tcccacagat ttcaatcagg attttgttat     1920

ttcctacttt gagctttaaa gggaaatggg cctcatgggt ggggaaagga tggtgggtcc     1980

ttccagccca atttagtgat gcccagggca gatattatcc tcagttccca agagcaatca     2040

tacttttcca cacataccgt gtgtctcatg ttaggtaaat gtatttttac aatgagcacc     2100

acttctgtgg aaaaagttcc ctgcacgggg aggtccagct tccagactgc tccatcgcat     2160

aaggacttcc ccattcccct aaatgctgct ctgtcagaac ctgcccaggt aatggtaatg     2220

accctagaga gatgatttct gaaccgcaat tttgagccca ttagaaggtg tgtggtgggc     2280

atttatttca tcctgatgct ctggtgagaa tctttgcaga cgcactagat ccagaagctg     2340

ttaatcttgg tgcatttatt ttcctaccta aaagaaccaa gcagctcaga ggcagtgact     2400

gtacaggatg cagtgtttat aataatgctg agcttgctgg tctggaaccc cacactttag     2460

caatcccagc attgttcctg tttatgaagt tgacaaagtg accagggcaa gggggtatta     2520

tcattaaata cactctagga gaggcagaac acatgagggc aatgtttttc agaggtcttt     2580

aggccaccgc atcagattct cctggagcat aaagcaaatg ctttatgagt ccagggcccc     2640

tgcagaccta ctgtatacta gtatacagct ccctcttagt ggatctcaag cttgtttcca     2700

aaaagtcatt acactcctta ccaaagccca tgacacattc atacagattc atccagacat     2760

aacccactgc atggtccagt gcatgcttgt gtgcttaact tattatagat caagtgttat     2820

ttaagtccaa catattaaac gtgactgaaa tattatatgc actaaatcgg aagacaaatg     2880

gccgtgctgg atactctccc atttgcactt acaggccacg ccatgctcca tcctccccat     2940

cctgcctggg aacctgacca atgtggctaa accagcaggc tccctggctg ccagcttctg     3000

gctggttgag ccaatgggaa gcatgagagg agagccgagg gtggggagac agtcagatca     3060

gggtttctgt cctcagggct ccctccctgg caggtggtgg caggagtggc tgcattcccc     3120

tctgaaggct ccttcaagcc tctcagcaaa cagctcccat ctccaagtcc agccacctgt     3180

tccatcctct cctctgtagg cccagcagtg ggaatgaccc accactattg ccagcctcag     3240

catactgaag caccccttac tggattccct aaattctatg cacatgttta ttaaatgctc     3300

ctcaattacc cagttaaaaa aaaaaaaaaa aaa                                  3333


<210>  5
<211>  2102
<212>  DNA
<213>  homo sapiens

<400>  5
attgtggtgc cttgtagctg tcccgggagc cctcagcagc agttggagct ggtgcacagg       60

aaggatgagg aagaccaggc tctgggggct gctgtggatg ctctttgtct cagaactccg      120

agctgcaact aaattaactg aggaaaagta tgaactgaaa gaggggcaga ccctggatgt      180

gaaatgtgac tacacgctag agaagtttgc cagcagccag aaagcttggc agataataag      240

ggacggagag atgcccaaga ccctggcatg cacagagagg ccttcaaaga attcccatcc      300

agtccaagtg gggaggatca tactagaaga ctaccatgat catggtttac tgcgcgtccg      360

aatggtcaac cttcaagtgg aagattctgg actgtatcag tgtgtgatct accagcctcc      420

caaggagcct cacatgctgt tcgatcgcat ccgcttggtg gtgaccaagg gtttttcagg      480

gacccctggc tccaatgaga attctaccca gaatgtgtat aagattcctc ctaccaccac      540

taaggccttg tgcccactct ataccagccc cagaactgtg acccaagctc cacccaagtc      600

aactgccgat gtctccactc ctgactctga aatcaacctt acaaatgtga cagatatcat      660

caggtatagt ttccaggtcc ctgggcccct ggtttggaca ctgagccctt tgtttcccag      720

tctgtgtgct gagaggatgt gaaagtgagg gaaaggggag ggtggggcag gagaagactt      780

gagtcacatt agtctgggta gaaatgtcca ggggaagaag gaagtggtga tggagaatag      840

gggaggctct cagccaggct gtccttctcc ccagttcacc ttctttgttt ccttgcaacc      900

tgagtattaa agagagggaa atggcatctt ccccaagttc cagtggagct catccaaccc      960

caggggcctg atgggcagtg ggaaagcact ctgagtgagg ggccctggat ctagtgttgg     1020

cctgactaac tgaatgtgac tttgggtgag tcaggaaccc tctctggctt tagcttcttt     1080

gacaattcag taggcatggt agaaacccaa agctggaaga cattgtccac ctaataactc     1140

tcagcaggag ctggagctgg ggctaaatgc agtattggtt tttgccttat tgttttttaa     1200

ataacattgt tgcatgtgcc caattataga taaatagaat cagaattttt gcagatgagg     1260

tccctctcag tatttttaat aagatgttta ggagatttct aatgtgtagg caaacttaag     1320

aaccactaac ttagcaattt cacacctctt tacagttatt aaatgttgat ttatattaga     1380

atgtgtttat cattaaatac tgaattatca ggatggaaat acttttccac atcaccacta     1440

gtctaacatg tcttttttct catattctct tctagtcttt attcatgttt atacatattt     1500

taatatggca gtaagtctaa ttatacatgt ttttattctt ttccttgctg aaattattct     1560

ttgatgctgc tacctaaatt tcataaatat aatttcaatg agtgcatatt tttctatcaa     1620

ttgggaaagc cataacttac ataaccattg gcctgttctt agacattgat atagtgttga     1680

taactctgag ataaacatat tcttgcagat atatttttct tcttttaaat aattaactcg     1740

aaatttccat gagataattt aaacactgat atcattttgt atacaaatag catctaccaa     1800

tggtcttcca aaagattgga aacaatttgc agtgtgatcc attaagcata aataaagcag     1860

tgtcatggca ggcttacaga cacggattta gtcttttaaa tcattaaata gtgtgagtta     1920

aatcacattc ctgctaaaac aaatgtgaac tggtgcctgc tctaatttct ctatgagtgt     1980

agactccacc tccatatggg tagtggcagt gcctttttcc ccattatgtt gtttggggaa     2040

caaagtgctc attaaacttc tgtggaataa atcaaacgaa tgatcaaaaa aaaaaaaaaa     2100

aa                                                                    2102


<210>  6
<211>  3140
<212>  DNA
<213>  homo sapiens

<400>  6
gtgcaacttt ccgaagcctc taggtcattg tggtgccttg tagctgtccc gggagccctc       60

agcagcagtt ggagctggtg cacaggaagg atgaggaaga ccaggctctg ggggctgctg      120

tggatgctct ttgtctcaga actccgagct gcaactaaat taactgagga aaagtatgaa      180

ctgaaagagg ggcagaccct ggatgtgaaa tgtgactaca cgctagagaa gtttgccagc      240

agccagaaag cttggcagat aataagggac ggagagatgc ccaagaccct ggcatgcaca      300

gagaggcctt caaagaattc ccatccagtc caagtgggga ggatcatact agaagactac      360

catgatcatg gtttactgcg cgtccgaatg gtcaaccttc aagtggaaga ttctggactg      420

tatcagtgtg tgatctacca gcctcccaag gagcctcaca tgctgttcga tcgcatccgc      480

ttggtggtga ccaaggggtt ccggtgttca acattgtcat tctcctggct ggtggattcc      540

tgagtaagag cctggtcttc tctgtcctgt ttgctgtcac gctgaggtca tttgtaccct      600

aggcccacga acccacgaga atgtcctctg acttccagcc acatccatct ggcagttgtg      660

ccaagggagg agggaggagg taaaaggcag ggagttaata acatgaatta aatctgtaat      720

caccggctat ttctaaagtc agcgtctcac cttcctgccc actgccctcg ttcctctaat      780

aatcttgggt gggcatttgt gcctcagaaa agaagttaca gccccaaaca tgcttggtcc      840

ttcattccac cagccacttg gggttggcat gaaatacaga cagctcaatg cttttcaccg      900

taattctctt gtgggggctg tgacatgcag aaggcacacc tgatacttct cctgctcagt      960

tttgccctgg accatacaat tttggcctga cctggacaga gctcccacta cagaagcatc     1020

ctgctcgccc catgctggga cttcctcttt ctagcatcag acacttgggt ttcatgctta     1080

tgtgtggttc tttccaacac tcccagaaaa gggtgttgaa gattgtggaa cctggagaaa     1140

taagacatcg tggtgagaaa gtgcatcctt ctcagagaaa agagttaaac tgagtatctt     1200

cttctgggga aatactggca ggccgagatg ggatccatag gagagcaaca acagaccatg     1260

tcagacatcc tgtgtgcatt tatcgctgga tcctgaaaat agccccgtga aggcagaaat     1320

gtatgtgact agaacgaggc cacatgaata agccactgcc cactggcagg agtgaaaact     1380

gaagcgctcc ttacctgaag gaccccaaaa ccatatagaa tagaataacc aggagttccg     1440

cctgtgtcta aatgcctctt ttcctgtatc acacaagggt cagggatggt ggagtaaaag     1500

ctctccccct gggaggcttc tggaggctgt ccccatgtgc ttgcctagtt ccccactctg     1560

ccctcctcct cttctctcag tctgctcctg gaacacctgc ctcagtttcc atgctctctc     1620

cagtgccctc cccggtgaag caggtaggtg ttcaggccac cacagagaca atctctgtgg     1680

gagattgtct tgcaatctcc cacagatttc aatcaggatt ttgttatttc ctactttgag     1740

ctttaaaggg aaatgggcct catgggtggg gaaaggatgg tgggtccttc cagcccaatt     1800

tagtgatgcc cagggcagat attatcctca gttcccaaga gcaatcatac ttttccacac     1860

ataccgtgtg tctcatgtta ggtaaatgta tttttacaat gagcaccact tctgtggaaa     1920

aagttccctg cacggggagg tccagcttcc agactgctcc atcgcataag gacttcccca     1980

ttcccctaaa tgctgctctg tcagaacctg cccaggtaat ggtaatgacc ctagagagat     2040

gatttctgaa ccgcaatttt gagcccatta gaaggtgtgt ggtgggcatt tatttcatcc     2100

tgatgctctg gtgagaatct ttgcagacgc actagatcca gaagctgtta atcttggtgc     2160

atttattttc ctacctaaaa gaaccaagca gctcagaggc agtgactgta caggatgcag     2220

tgtttataat aatgctgagc ttgctggtct ggaaccccac actttagcaa tcccagcatt     2280

gttcctgttt atgaagttga caaagtgacc agggcaaggg ggtattatca ttaaatacac     2340

tctaggagag gcagaacaca tgagggcaat gtttttcaga ggtctttagg ccaccgcatc     2400

agattctcct ggagcataaa gcaaatgctt tatgagtcca gggcccctgc agacctactg     2460

tatactagta tacagctccc tcttagtgga tctcaagctt gtttccaaaa agtcattaca     2520

ctccttacca aagcccatga cacattcata cagattcatc cagacataac ccactgcatg     2580

gtccagtgca tgcttgtgtg cttaacttat tatagatcaa gtgttattta agtccaacat     2640

attaaacgtg actgaaatat tatatgcact aaatcggaag acaaatggcc gtgctggata     2700

ctctcccatt tgcacttaca ggccacgcca tgctccatcc tccccatcct gcctgggaac     2760

ctgaccaatg tggctaaacc agcaggctcc ctggctgcca gcttctggct ggttgagcca     2820

atgggaagca tgagaggaga gccgagggtg gggagacagt cagatcaggg tttctgtcct     2880

cagggctccc tccctggcag gtggtggcag gagtggctgc attcccctct gaaggctcct     2940

tcaagcctct cagcaaacag ctcccatctc caagtccagc cacctgttcc atcctctcct     3000

ctgtaggccc agcagtggga atgacccacc actattgcca gcctcagcat actgaagcac     3060

cccttactgg attccctaaa ttctatgcac atgtttatta aatgctcctc aattacccag     3120

ttaaaaaaaa aaaaaaaaaa                                                 3140


<210>  7
<211>  233
<212>  PRT
<213>  Macaca fascicularis

<400>  7

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Thr Thr Glu Leu Thr Glu Glu Lys Tyr Glu Tyr Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Glu Val Lys Cys Asp Tyr Ala Leu Glu Lys Tyr 
        35                  40                  45              


Ala Asn Ser Arg Lys Ala Trp Gln Lys Met Glu Gly Lys Met Pro Lys 
    50                  55                  60                  


Ile Leu Ala Lys Thr Glu Arg Pro Ser Glu Asn Ser His Pro Val Gln 
65                  70                  75                  80  


Val Gly Arg Ile Thr Leu Glu Asp Tyr Pro Asp His Gly Leu Leu Gln 
                85                  90                  95      


Val Gln Met Thr Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln Cys 
            100                 105                 110         


Val Ile Tyr Gln His Pro Lys Glu Ser His Val Leu Phe Asn Pro Ile 
        115                 120                 125             


Cys Leu Val Val Thr Lys Gly Ser Ser Gly Thr Pro Gly Ser Ser Glu 
    130                 135                 140                 


Asn Ser Thr Gln Asn Val Tyr Arg Thr Pro Ser Thr Thr Ala Lys Ala 
145                 150                 155                 160 


Leu Gly Pro Arg Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro Pro 
                165                 170                 175     


Glu Ser Thr Val Val Val Ser Thr Pro Gly Ser Glu Ile Asn Leu Thr 
            180                 185                 190         


Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn Ile Val Ile Ile 
        195                 200                 205             


Val Ala Gly Gly Phe Leu Ser Lys Ser Leu Val Phe Ser Val Leu Phe 
    210                 215                 220                 


Ala Val Thr Leu Arg Ser Phe Gly Pro 
225                 230             


<210>  8
<211>  196
<212>  PRT
<213>  homo sapiens

<400>  8

Met Ser Arg Arg Ser Met Leu Leu Ala Trp Ala Leu Pro Ser Leu Leu 
1               5                   10                  15      


Arg Leu Gly Ala Ala Gln Glu Thr Glu Asp Pro Ala Cys Cys Ser Pro 
            20                  25                  30          


Ile Val Pro Arg Asn Glu Trp Lys Ala Leu Ala Ser Glu Cys Ala Gln 
        35                  40                  45              


His Leu Ser Leu Pro Leu Arg Tyr Val Val Val Ser His Thr Ala Gly 
    50                  55                  60                  


Ser Ser Cys Asn Thr Pro Ala Ser Cys Gln Gln Gln Ala Arg Asn Val 
65                  70                  75                  80  


Gln His Tyr His Met Lys Thr Leu Gly Trp Cys Asp Val Gly Tyr Asn 
                85                  90                  95      


Phe Leu Ile Gly Glu Asp Gly Leu Val Tyr Glu Gly Arg Gly Trp Asn 
            100                 105                 110         


Phe Thr Gly Ala His Ser Gly His Leu Trp Asn Pro Met Ser Ile Gly 
        115                 120                 125             


Ile Ser Phe Met Gly Asn Tyr Met Asp Arg Val Pro Thr Pro Gln Ala 
    130                 135                 140                 


Ile Arg Ala Ala Gln Gly Leu Leu Ala Cys Gly Val Ala Gln Gly Ala 
145                 150                 155                 160 


Leu Arg Ser Asn Tyr Val Leu Lys Gly His Arg Asp Val Gln Arg Thr 
                165                 170                 175     


Leu Ser Pro Gly Asn Gln Leu Tyr His Leu Ile Gln Asn Trp Pro His 
            180                 185                 190         


Tyr Arg Ser Pro 
        195     


<210>  9
<211>  330
<212>  PRT
<213>  homo sapiens

<400>  9

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  10
<211>  327
<212>  PRT
<213>  homo sapiens

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  11
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1-Aba Heavy Chain Constant Region

<400>  11

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  12
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4-Aba Heavy Chain Constant Region

<400>  12

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  13
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  13

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  14
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 0318 VH

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  15
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 0318 VL

<400>  15

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Thr Phe 
            20                  25                  30          


Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Gln Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  16
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.3f VH

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  17
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.3f VL

<400>  17

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Thr Phe 
            20                  25                  30          


Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Gln Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  18
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.1f VH

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  19
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.1f VL

<400>  19

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Thr Phe 
            20                  25                  30          


Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Gln Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  20
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1-Aba VH

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1-Aba VL

<400>  21

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Thr Phe 
            20                  25                  30          


Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Gln Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  22
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG4-Aba VH

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  23
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG4-Aba VL

<400>  23

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Thr Phe 
            20                  25                  30          


Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Gln Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.3f VH CDR1

<400>  24

Thr Tyr Ala Met His 
1               5   


<210>  25
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.3f VH CDR2

<400>  25

Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.3f VH CDR3

<400>  26

Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr 
1               5                   10  


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.3f VL CDR1

<400>  27

Arg Ala Ser Gln Ser Val Asp Thr Phe Asp Tyr Ser Phe Leu His 
1               5                   10                  15  


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.3f VL CDR2

<400>  28

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.3f VL CDR3

<400>  29

Gln Gln Ser Asn Gln Asp Pro Tyr Thr 
1               5                   


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.1f VH CDR1

<400>  30

Thr Tyr Ala Met His 
1               5   


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.1f VH CDR2

<400>  31

Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.1f VH CDR3

<400>  32

Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr 
1               5                   10  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.1f VL CDR1

<400>  33

Arg Ala Ser Gln Ser Val Asp Thr Phe Asp Tyr Ser Phe Leu His 
1               5                   10                  15  


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.1f VL CDR2

<400>  34

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.1f VL CDR3

<400>  35

Gln Gln Ser Asn Gln Asp Pro Tyr Thr 
1               5                   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1-Aba VH CDR1

<400>  36

Thr Tyr Ala Met His 
1               5   


<210>  37
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1-Aba VH CDR2

<400>  37

Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1-Aba VH CDR3

<400>  38

Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr 
1               5                   10  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1-Aba VL CDR1

<400>  39

Arg Ala Ser Gln Ser Val Asp Thr Phe Asp Tyr Ser Phe Leu His 
1               5                   10                  15  


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1-Aba VL CDR2

<400>  40

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1-Aba VL CDR3

<400>  41

Gln Gln Ser Asn Gln Asp Pro Tyr Thr 
1               5                   


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG4-Aba VH CDR1

<400>  42

Thr Tyr Ala Met His 
1               5   


<210>  43
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG4-Aba VH CDR2

<400>  43

Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG4-Aba VH CDR3

<400>  44

Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr 
1               5                   10  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG4-Aba VL CDR1

<400>  45

Arg Ala Ser Gln Ser Val Asp Thr Phe Asp Tyr Ser Phe Leu His 
1               5                   10                  15  


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG4-Aba VL CDR2

<400>  46

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG4-Aba VL CDR3

<400>  47

Gln Gln Ser Asn Gln Asp Pro Tyr Thr 
1               5                   


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LSPGK (C-terminal end of heavy chain)

<400>  48

Leu Ser Pro Gly Lys 
1               5   


<210>  49
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LSPG (C-terminal end of heavy chain)

<400>  49

Leu Ser Pro Gly 
1               


<210>  50
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.3f HC

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
225                 230                 235                 240 


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  51
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.1f HC

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
225                 230                 235                 240 


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  52
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1-Aba HC

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  53
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG4-Aba HC

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  54
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.3f LC

<400>  54

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Thr Phe 
            20                  25                  30          


Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Gln Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  55
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.1f LC

<400>  55

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Thr Phe 
            20                  25                  30          


Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Gln Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  56
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG1-Aba LC

<400>  56

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Thr Phe 
            20                  25                  30          


Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Gln Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  57
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318-IgG4-Aba LC

<400>  57

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Thr Phe 
            20                  25                  30          


Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Gln Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  58
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.3f HC

<400>  58
atgagggctt ggatcttctt tctgctctgc ctggccgggc gcgccttggc cgaagtgcag       60

ctcgtggagt ccggcggagg actggtccaa cctggcggct ccctgaagct gtcctgcgct      120

gcctccggct tcaccttctc cacctacgcc atgcactggg tcaggcaggc ctccggaaag      180

ggcctggaat gggtcggccg gattaggacc aagtccagca actacgctac ctactacgcc      240

gccagcgtca agggccggtt cacaatctcc cgggacgact ccaagaacac cgcctatctc      300

cagatgaaca gcctgaagac agaggacacc gccgtgtact attgcacccg ggatatgggc      360

attcggaggc agttcgccta ttggggccag ggcaccctgg tgacagtcag ctccgccagc      420

acaaaaggac ctagcgtgtt ccccctggcc cctagcagca agtccacaag cggcggcacc      480

gctgccctgg gctgtctggt gaaagactac tttcccgagc ccgtgacagt gagctggaac      540

tctggcgccc tgacatccgg agtgcacacc ttccctgccg tgctccagtc cagcggcctg      600

tacagcctga gcagcgtcgt gaccgtccct agcagcagcc tgggaaccca gacctacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agagggtgga gcccaagtcc      720

tgtgacaaga cccatacctg ccccccctgt cctgctcctg aagctgaggg cgccccttcc      780

gtcttcctgt tccctcctaa gcccaaggac accctgatga tctccaggac ccccgaggtg      840

acctgtgtgg tggtggatgt gtcccacgag gaccccgagg tgaagttcaa ttggtacgtc      900

gacggcgtgg aggtgcacaa cgccaagacc aaaccccggg aggagcagta taacagcacc      960

taccgggtgg tgtccgtgct caccgtgctg caccaggact ggctgaacgg caaggagtac     1020

aagtgtaagg tcagcaataa ggccctgcct gcccccatcg agaagaccat tagcaaggct     1080

aagggccagc ccagggaacc ccaggtgtat accctccccc ctagccggga ggagatgacc     1140

aagaaccagg tcagcctgac ctgcctggtg aaaggattct accctagcga catcgctgtg     1200

gagtgggaga gcaatggaca gcccgagaac aactacaaaa ccacccctcc cgtcctggac     1260

tccgatggca gcttctttct gtactccaag ctcaccgtcg acaagagccg gtggcagcag     1320

ggcaatgtgt ttagctgctc cgtgatgcac gaggctctgc acaaccacta tacccaaaag     1380

tccctgtccc tcagccccgg caagtga                                         1407


<210>  59
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.1f HC

<400>  59
atgagggctt ggatcttctt tctgctctgc ctggccgggc gcgccttggc cgaagtgcag       60

ctggtggaaa gcggcggagg actggtgcag ccaggcggca gcctgaagct gtcttgcgcc      120

gccagcggct tcaccttcag cacctacgcc atgcactggg tccgccaggc cagcggcaag      180

ggcctggaat gggtcggacg gatccggacc aagagcagca actacgccac ctactacgcc      240

gcctccgtga agggccggtt caccatcagc cgggacgaca gcaagaacac cgcctacctg      300

cagatgaaca gcctgaaaac cgaggacacc gccgtgtact actgcacccg ggacatgggc      360

atccggcggc agtttgccta ctggggccag ggcaccctgg tcacagtgtc cagcgcgtcg      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgaagg ggccccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tctccaacaa agccctccca agcagcatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtccccggg ttga                                            1404


<210>  60
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0318-IgG1-Aba HC

<400>  60
atgagggctt ggatcttctt tctgctctgc ctggccgggc gcgccttggc cgaggtccag       60

ctggtggaga gcggaggagg actcgtgcag cctggaggat ccctgaagct gtcctgcgct      120

gcctccggct ttaccttctc cacctacgcc atgcattggg tgaggcaggc ctccggcaag      180

ggcctggaat gggtgggcag gatcaggaca aagagctcca actacgccac ctactacgcc      240

gccagcgtga aaggacggtt caccatctcc cgggacgatt ccaaaaacac cgcctacctc      300

cagatgaata gcctgaagac cgaggacacc gccgtctact actgcaccag ggatatgggc      360

atccggcggc agtttgccta ctggggccag ggcaccctgg tgacagtgtc cagcgctagc      420

accaaaggcc cctccgtgtt ccccctggct ccctccagca agtccacatc cggcggaacc      480

gccgctctgg gatgtctggt gaaggactac ttccccgagc ccgtgacagt gagctggaac      540

tctggcgctc tgacctccgg cgtgcacacc tttcctgctg tgctgcagtc ctccggcctc      600

tacagcctgt cctccgtcgt gacagtgccc tcctccagcc tgggcaccca gacctacatc      660

tgcaacgtga accacaagcc ttccaacacc aaggtggata agcgggtcga acccaagagc      720

tgcgacaaga cccacaccag ccccccttcc cctgctcccg agctcctggg aggcagctcc      780

gtgtttctgt ttccccccaa gcctaaggac accctgatga tcagcaggac ccccgaagtg      840

acatgcgtgg tggtcgacgt gtcccacgag gaccccgagg tcaagttcaa ctggtacgtg      900

gatggagtgg aggtccataa tgccaagacc aagccccggg aggagcagta caattccacc      960

taccgggtgg tgtccgtgct gacagtcctg catcaggact ggctcaacgg caaggagtac     1020

aaatgcaagg tgtccaacaa ggctctgccc gcccccatcg agaagacaat cagcaaggct     1080

aagggccagc ctagggagcc ccaggtgtac accctgcccc cttccaggga cgagctcacc     1140

aagaaccagg tgtccctgac atgcctcgtg aagggctttt accctagcga catcgctgtg     1200

gagtgggagt ccaacggaca gcccgagaac aactacaaga caacaccccc tgtgctggac     1260

tccgacggct ccttcttcct gtacagcaag ctcaccgtgg acaaatcccg gtggcagcag     1320

ggaaacgtgt tcagctgctc cgtgatgcat gaggccctgc acaaccatta cacccagaaa     1380

tccctgtccc tgtcccccgg caagtga                                         1407


<210>  61
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0318-IgG4-Aba HC

<400>  61
atgagggctt ggatcttctt tctgctctgc ctggccgggc gcgccttggc cgaggtccag       60

ctggtcgaga gcggcggagg actggtccag cctggaggat ccctgaagct ctcctgtgcc      120

gctagcggat ttaccttcag cacctacgct atgcattggg tgaggcaggc ttccggcaag      180

ggactggagt gggtgggacg gattcggacc aagagctcca attacgccac ctattacgcc      240

gcttccgtga agggccggtt caccatctcc agggacgact ccaagaacac cgcttacctg      300

cagatgaact ccctcaagac cgaggacacc gccgtgtatt actgcacccg ggacatgggc      360

atccggaggc agttcgctta ttggggacag ggcaccctgg tgaccgtgag ctccgcctcc      420

accaagggcc cttccgtgtt ccctctggcc ccctgtagca ggtccaccag cgagtccaca      480

gctgctctgg gctgtctggt gaaggattat ttccccgagc ccgtgacagt gtcctggaat      540

agcggcgccc tgacctccgg cgtgcatacc ttccctgccg tcctgcaaag cagcggcctg      600

tacagcctgt cctccgtggt gacagtccct tcctccagcc tgggaaccaa gacctacacc      660

tgcaatgtgg accacaagcc tagcaacacc aaggtggaca agagggtcga gcccaagtcc      720

tgcgataaga cacacacctc ccctccttcc cctgctcctg agctgctcgg cggaagcagc      780

gtgttcctgt tccctcctaa gcctaaggac accctgatga tcagccggac ccctgaggtg      840

acctgtgtcg tggtggacgt gtcccacgaa gaccccgagg tgaaattcaa ctggtacgtg      900

gacggcgtcg aggtgcacaa cgctaagaca aaacccaggg aggagcagta caattccacc      960

taccgggtcg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagagtac     1020

aagtgtaagg tcagcaataa ggccctgcct gcccccattg agaagaccat ttccaaggcc     1080

aagggccagc ccagggaacc tcaggtgtac accctgcctc cctcccggga cgagctgacc     1140

aagaaccagg tcagcctgac ctgcctcgtg aagggcttct accctagcga catcgccgtg     1200

gagtgggagt ccaacggcca gcctgagaac aattacaaga ccaccccccc tgtcctggac     1260

tccgacggat ccttcttcct gtactccaag ctgacagtgg ataagtcccg gtggcagcag     1320

ggaaatgtgt tctcctgctc cgtcatgcac gaagccctgc ataaccacta cacacagaag     1380

agcctgtccc tgagccctgg caagtga                                         1407


<210>  62
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.3f LC

<400>  62
atgagggctt ggatcttctt tctgctctgc ctggccgggc gcgccttggc cgatatcgtg       60

ctgacccaga gccccgatag cctggctgtg agcctgggcg agagagccac catcaactgc      120

agggcctccc agagcgtcga caccttcgac tacagcttcc tccactggta ccagcagaag      180

cctggccagc cccccaagct gctgatctac agggccagca acctggagag cggagtgccc      240

gataggttca gcggcagcgg ctccggaacc gactttaccc tcaccatcag ctccctgcag      300

gccgaggatg tggccgtcta ctactgccag cagagcaacc aggaccccta cacctttggc      360

cagggcacca agctggagat caagaggacc gtggccgccc cctccgtgtt catcttccct      420

cccagcgacg agcagctgaa gagcggaacc gccagcgtgg tgtgcctgct gaacaacttc      480

taccccaggg aggccaaggt gcagtggaag gtcgacaacg ccctgcagag cggcaatagc      540

caggagagcg tgaccgaaca ggacagcaag gactccacct actccctgag cagcaccctg      600

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgtgaggt gacccaccag      660

ggactgagca gccccgtgac aaagagcttt aacaggggcg agtgctga                   708


<210>  63
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0318-IgG1.1f LC

<400>  63
atgagggctt ggatcttctt tctgctctgc ctggccgggc gcgccttggc cgatatcgtg       60

ctgacccaga gccccgatag cctggctgtg agcctgggcg agagagccac catcaactgc      120

agggcctccc agagcgtcga caccttcgac tacagcttcc tccactggta ccagcagaag      180

cctggccagc cccccaagct gctgatctac agggccagca acctggagag cggagtgccc      240

gataggttca gcggcagcgg ctccggaacc gactttaccc tcaccatcag ctccctgcag      300

gccgaggatg tggccgtcta ctactgccag cagagcaacc aggaccccta cacctttggc      360

cagggcacca agctggagat caagaggacc gtggccgccc cctccgtgtt catcttccct      420

cccagcgacg agcagctgaa gagcggaacc gccagcgtgg tgtgcctgct gaacaacttc      480

taccccaggg aggccaaggt gcagtggaag gtcgacaacg ccctgcagag cggcaatagc      540

caggagagcg tgaccgaaca ggacagcaag gactccacct actccctgag cagcaccctg      600

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgtgaggt gacccaccag      660

ggactgagca gccccgtgac aaagagcttt aacaggggcg agtgctga                   708


<210>  64
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0318-IgG1-Aba LC

<400>  64
atgagggctt ggatcttctt tctgctctgc ctggccgggc gcgccttggc cgatatcgtg       60

ctgacccaga gccccgatag cctggctgtg agcctgggcg agagagccac catcaactgc      120

agggcctccc agagcgtcga caccttcgac tacagcttcc tccactggta ccagcagaag      180

cctggccagc cccccaagct gctgatctac agggccagca acctggagag cggagtgccc      240

gataggttca gcggcagcgg ctccggaacc gactttaccc tcaccatcag ctccctgcag      300

gccgaggatg tggccgtcta ctactgccag cagagcaacc aggaccccta cacctttggc      360

cagggcacca agctggagat caagaggacc gtggccgccc cctccgtgtt catcttccct      420

cccagcgacg agcagctgaa gagcggaacc gccagcgtgg tgtgcctgct gaacaacttc      480

taccccaggg aggccaaggt gcagtggaag gtcgacaacg ccctgcagag cggcaatagc      540

caggagagcg tgaccgaaca ggacagcaag gactccacct actccctgag cagcaccctg      600

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgtgaggt gacccaccag      660

ggactgagca gccccgtgac aaagagcttt aacaggggcg agtgctga                   708


<210>  65
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0318-IgG4-Aba LC

<400>  65
atgagggctt ggatcttctt tctgctctgc ctggccgggc gcgccttggc cgatatcgtg       60

ctgacccaga gccccgatag cctggctgtg agcctgggcg agagagccac catcaactgc      120

agggcctccc agagcgtcga caccttcgac tacagcttcc tccactggta ccagcagaag      180

cctggccagc cccccaagct gctgatctac agggccagca acctggagag cggagtgccc      240

gataggttca gcggcagcgg ctccggaacc gactttaccc tcaccatcag ctccctgcag      300

gccgaggatg tggccgtcta ctactgccag cagagcaacc aggaccccta cacctttggc      360

cagggcacca agctggagat caagaggacc gtggccgccc cctccgtgtt catcttccct      420

cccagcgacg agcagctgaa gagcggaacc gccagcgtgg tgtgcctgct gaacaacttc      480

taccccaggg aggccaaggt gcagtggaag gtcgacaacg ccctgcagag cggcaatagc      540

caggagagcg tgaccgaaca ggacagcaag gactccacct actccctgag cagcaccctg      600

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgtgaggt gacccaccag      660

ggactgagca gccccgtgac aaagagcttt aacaggggcg agtgctga                   708


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318 Ab - VH CDR1

<400>  66

Thr Tyr Ala Met His 
1               5   


<210>  67
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318 Ab - VH CDR2

<400>  67

Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318 Ab - VH CDR3

<400>  68

Asp Met Gly Gln Arg Arg Gln Phe Ala Tyr 
1               5                   10  


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318 Ab - VL CDR1

<400>  69

Arg Ala Ser Glu Ser Val Asp Thr Phe Asp Tyr Ser Phe Leu His 
1               5                   10                  15  


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318 Ab - VL CDR2

<400>  70

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318 Ab - VL CDR3

<400>  71

Gln Gln Ser Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318 AB - VH CDR3 (mutant)

<400>  72

Asp Gln Gly Ile Arg Arg Gln Phe Ala Tyr 
1               5                   10  


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318 AB - VH CDR3 (mutant)

<400>  73

Asp Leu Gly Ile Arg Arg Gln Phe Ala Tyr 
1               5                   10  


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318 Ab - VH CDR1 (mutant)

<400>  74

Thr Tyr Ala Gln His 
1               5   


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318 Ab - VH CDR1 (mutant)

<400>  75

Thr Tyr Ala Leu His 
1               5   


<210>  76
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0318 Ab - HC (IgG4)

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val 
        435                 440                 445             


Ser Leu Gly 
    450     


<210>  77
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT IgG1 Constant Region (Allotypic Variant)

<400>  77

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  78
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1.1f HC Constant Region

<400>  78

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  79
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1.3f HC Constant Region

<400>  79

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  80

Pro Val Gly Val Val 
1               5   


<210>  81
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  318 Ab - Mutant

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Gln Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  82
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  319 Ab - Mutant

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Leu Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  83
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  320 Ab - Mutant

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Gln His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  84
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  321 Ab - Mutant

<400>  84

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Leu His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


