                               SEQUENCE LISTING

<110> GILEAD SCIENCES, INC.
 
<120> ANTIBODIES AND FRAGMENTS THEREOF THAT BIND HEPATITIS B VIRUS 
      PROTEIN X

<130> 1245.PF

<140>
<141>

<150> 62/653,378
<151> 2018-04-05

<160> 73    

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy CDR1 Kabat"

<400> 1
Asp Tyr Tyr Met Asn 
1               5   


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy CDR2 Kabat"

<400> 2
Asp Ile Asn Pro Asn Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light CDR1 Kabat"

<400> 3
Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr His Leu His 
1               5                   10                  15      


<210> 4
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light CDR2 Kabat"

<400> 4
Lys Ala Ser Asn Arg Phe Ser 
1               5           


<210> 5
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light CDR3 Kabat"

<400> 5
Ser Gln Ser Thr His Val Pro Leu Thr 
1               5                   


<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy CDR1 IMGT"

<400> 6
Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy CDR2 IMGT"

<400> 7
Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210> 8
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy CDR3 IMGT"

<400> 8
Ala Leu Leu Ala Tyr 
1               5   


<210> 9
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light CDR1 IMGT"

<400> 9
Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr His 
1               5                   10      


<210> 10
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light CDR3 IMGT"

<400> 10
Ser Gln Ser Thr His Val Pro Leu Thr 
1               5                   


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy CDR1 Chothia"

<400> 11
Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210> 12
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy CDR2 Chothia"

<400> 12
Pro Asn Asn Gly 
1               


<210> 13
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light CDR1 Chothia"

<400> 13
Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr His 
1               5                   10          


<210> 14
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light CDR3 Chothia"

<400> 14
Ser Thr His Val Pro Leu 
1               5       


<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy CDR1 Honegger"

<400> 15
Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5                   10  


<210> 16
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy CDR2 Honegger"

<400> 16
Ile Asn Pro Asn Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys Gly 
1               5                   10                  15      


Lys 
    


<210> 17
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light CDR1 Honegger"

<400> 17
Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr His 
1               5                   10              


<210> 18
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light CDR2 Honegger"

<400> 18
Lys Ala Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
1               5                   10          


<210> 19
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light CDR3 Honegger"

<400> 19
Ser Thr His Val Pro Leu 
1               5       


<210> 20
<211> 436
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Variant of HBx M19 Heavy Chain"

<400> 20
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105                 110         


Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
        115                 120                 125             


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
                165                 170                 175     


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
            180                 185                 190         


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
        195                 200                 205             


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
    210                 215                 220                 


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
225                 230                 235                 240 


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
                245                 250                 255     


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
            260                 265                 270         


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        275                 280                 285             


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
    290                 295                 300                 


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
305                 310                 315                 320 


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
                325                 330                 335     


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
            340                 345                 350         


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
        355                 360                 365             


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
    370                 375                 380                 


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
385                 390                 395                 400 


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
                405                 410                 415     


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
            420                 425                 430         


Ser Pro Gly Lys 
        435     


<210> 21
<211> 101
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy Chain Variable Region without -(D)-J Sequence"

<400> 21
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Leu Ala Tyr 
            100     


<210> 22
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy Chain Variable Region"

<400> 22
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105                 110         


<210> 23
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light Chain Variable Region without -(D)-J Sequence"

<400> 23
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr His Leu His Trp Tyr Leu Gln Lys Thr Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Leu Thr 
            100         


<210> 24
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light Chain Variable Region"

<400> 24
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr His Leu His Trp Tyr Leu Gln Lys Thr Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 25
<211> 324
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Mouse IgG"

<400> 25
Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Lys Pro Arg Glu Glu Gln Ile Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asn Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210> 26
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light Chain Constant Region"

<400> 26
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210> 27
<211> 436
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy Chains of HBx M19"

<400> 27
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105                 110         


Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
        115                 120                 125             


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
                165                 170                 175     


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val 
            180                 185                 190         


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
        195                 200                 205             


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
    210                 215                 220                 


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
225                 230                 235                 240 


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
                245                 250                 255     


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
            260                 265                 270         


Val His Thr Ala Gln Thr Lys Pro Arg Glu Glu Gln Ile Asn Ser Thr 
        275                 280                 285             


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
    290                 295                 300                 


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
305                 310                 315                 320 


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
                325                 330                 335     


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
            340                 345                 350         


Ser Leu Thr Cys Met Ile Thr Asn Phe Phe Pro Glu Asp Ile Thr Val 
        355                 360                 365             


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
    370                 375                 380                 


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
385                 390                 395                 400 


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
                405                 410                 415     


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
            420                 425                 430         


Ser Pro Gly Lys 
        435     


<210> 28
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Leader peptide that may be present at the N-terminus of a heavy "
      chain

<400> 28
Met Gly Trp Ser Trp Val Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser 
            


<210> 29
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy Chain -(D)-J Sequence"

<400> 29
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210> 30
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light Chain"

<400> 30
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr His Leu His Trp Tyr Leu Gln Lys Thr Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 31
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Leader peptide that may be present at the N-terminus of a light "
      chain

<400> 31
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser 
            


<210> 32
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light Chain -(D)-J Sequence"

<400> 32
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210> 33
<211> 324
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy Chain Constant Region"

<400> 33
Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210> 34
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy Chain"

<400> 34
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105                 110         


Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly 
        115                 120                 125             


Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
    130                 135                 140                 


Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn 
145                 150                 155                 160 


Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys 
            180                 185                 190         


Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala 
        195                 200                 205             


Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly 
    210                 215                 220                 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
225                 230                 235                 240 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
                245                 250                 255     


Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val 
            260                 265                 270         


Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile 
        275                 280                 285             


Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly 
    290                 295                 300                 


Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile 
305                 310                 315                 320 


Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val 
                325                 330                 335     


Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser 
            340                 345                 350         


Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu 
        355                 360                 365             


Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala 
    370                 375                 380                 


Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
385                 390                 395                 400 


Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met 
                405                 410                 415     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser 
            420                 425                 430         


Pro Gly Lys 
        435 


<210> 35
<211> 323
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy Chain Constant Region"

<400> 35
Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly 
1               5                   10                  15      


Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn 
        35                  40                  45              


Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys 
65                  70                  75                  80  


Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala 
                85                  90                  95      


Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly 
            100                 105                 110         


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        115                 120                 125             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    130                 135                 140                 


Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val 
145                 150                 155                 160 


Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile 
                165                 170                 175     


Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly 
            180                 185                 190         


Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile 
        195                 200                 205             


Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val 
    210                 215                 220                 


Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser 
225                 230                 235                 240 


Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu 
                245                 250                 255     


Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala 
            260                 265                 270         


Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
        275                 280                 285             


Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met 
    290                 295                 300                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser 
305                 310                 315                 320 


Pro Gly Lys 
            


<210> 36
<211> 216
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light Chain"

<400> 36
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr His Leu His Trp Tyr Leu Gln Lys Thr Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp 
        115                 120                 125             


Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr 
    130                 135                 140                 


Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr 
145                 150                 155                 160 


Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Ser Thr 
                165                 170                 175     


Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser 
            180                 185                 190         


His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val 
        195                 200                 205             


Gln Ser Phe Asn Arg Gly Asp Cys 
    210                 215     


<210> 37
<211> 104
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light Chain Constant Region"

<400> 37
Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp 
1               5                   10                  15      


Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr 
            20                  25                  30          


Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr 
        35                  40                  45              


Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Ser Thr 
    50                  55                  60                  


Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser 
65                  70                  75                  80  


His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val 
                85                  90                  95      


Gln Ser Phe Asn Arg Gly Asp Cys 
            100                 


<210> 38
<211> 322
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Rat IgG"

<400> 38
Ala Glu Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Gly Thr Ala 
1               5                   10                  15      


Leu Lys Ser Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Gly Leu Tyr Thr Leu 
    50                  55                  60                  


Thr Ser Ser Val Thr Val Pro Ser Ser Thr Trp Ser Ser Gln Ala Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Glu Cys Asn Pro Cys Gly Cys Thr Gly Ser Glu Val 
            100                 105                 110         


Ser Ser Val Phe Ile Phe Pro Pro Lys Thr Lys Asp Val Leu Thr Ile 
        115                 120                 125             


Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Gln Asn 
    130                 135                 140                 


Asp Pro Glu Val Arg Phe Ser Trp Phe Ile Asp Asp Val Glu Val His 
145                 150                 155                 160 


Thr Ala Gln Thr His Ala Pro Glu Lys Gln Ser Asn Ser Thr Leu Arg 
                165                 170                 175     


Ser Val Ser Glu Leu Pro Ile Val His Arg Asp Trp Leu Asn Gly Lys 
            180                 185                 190         


Thr Phe Lys Cys Lys Val Asn Ser Gly Ala Phe Pro Ala Pro Ile Glu 
        195                 200                 205             


Lys Ser Ile Ser Lys Pro Glu Gly Thr Pro Arg Gly Pro Gln Val Tyr 
    210                 215                 220                 


Thr Met Ala Pro Pro Lys Glu Glu Met Thr Gln Ser Gln Val Ser Ile 
225                 230                 235                 240 


Thr Cys Met Val Lys Gly Phe Tyr Pro Pro Asp Ile Tyr Thr Glu Trp 
                245                 250                 255     


Lys Met Asn Gly Gln Pro Gln Glu Asn Tyr Lys Asn Thr Pro Pro Thr 
            260                 265                 270         


Met Asp Thr Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Asn Val Lys 
        275                 280                 285             


Lys Glu Thr Trp Gln Gln Gly Asn Thr Phe Thr Cys Ser Val Leu His 
    290                 295                 300                 


Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro 
305                 310                 315                 320 


Gly Lys 
        


<210> 39
<211> 1402
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy Chain Coding Sequence"

<400> 39
acccaagctg gctagccgcc accatgaaat gggtcacctt tatcagcctg ctgttcctgt       60

tcagcagcgc ctactctgag gtccagctgc agcaatctgg ccccgagctt gtgaaacctg      120

gcgcctctgt gaagatcagc tgtcaggcca gcggctacac cttcaccgac tactacatga      180

actgggttaa gcagagccac ggcaagcggc tggaatggat cggcgacatc aaccccaaca      240

atggcggcac cgcctacaac cagaagttca agggcaaagc cacactgacc gtggacagaa      300

gcagcagcac agcctacatg gaagtgcgga gcctgaccag cgaagatagc gccgtgtact      360

tctgtgccct gctggcctat tggggccagg gaacactggt tacagtgtcc gctgggcaac      420

ctaaggctcc atcagtcttc ccactggcac catgctgcgg tgacacacct agctccacgg      480

tgaccctggg atgcctggtc aaaggctacc tcccagagcc agtgaccgtg acctggaact      540

cgggtacact caccaatggt gtacgcacct tcccatccgt ccggcagtcc tcaggactct      600

actcgctgtc gagcgttgtg agcgtgacct caagcagcca gcctgtcacc tgcaacgtgg      660

ctcacccagc tactaacacc aaagtggaca agaccgttgc accatcgaca tgcagcaagc      720

ctacgtgccc acctcctgaa ctcctgggtg gaccgtctgt cttcatcttc cctccaaaac      780

ctaaggacac cctcatgatc tcacgcacac ctgaggtcac atgcgttgtt gtggacgtga      840

gccaggatga cccagaggtg cagttcacat ggtacataaa caacgagcag gttcgcacag      900

ctcggcctcc tctacgagag caacagttca acagcacgat ccgcgtggtc agcacactcc      960

ctatcgcgca ccaggactgg ctgaggggta aggagttcaa gtgcaaagtc cacaacaagg     1020

cactccctgc tcctatcgag aaaaccatct ccaaagccag aggtcagcct ctggagccga     1080

aggtctacac catgggacct ccacgggagg agctgagcag caggtcggtc agcctgacct     1140

gcatgatcaa cggattctac ccttccgaca tctcggtgga gtgggagaag aacggtaagg     1200

cagaggacaa ctacaagacc acgcctgccg tgctggacag cgacggttcc tacttcctct     1260

acagcaagct ctcagtgcct acgagtgagt ggcagcgggg tgacgtcttc acctgctccg     1320

tgatgcacga ggccttgcac aaccactaca cgcagaagtc catctcccgc tctccgggta     1380

agtaggaatt ctgcagatat ca                                              1402


<210> 40
<211> 5428
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      vector  pcDNA?3.1+"

<400> 40
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

gtttaaactt aagcttggta ccgagctcgg atccactagt ccagtgtggt ggaattctgc      960

agatatccag cacagtggcg gccgctcgag tctagagggc ccgtttaaac ccgctgatca     1020

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     1080

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     1140

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     1200

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag     1260

gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta     1320

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     1380

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     1440

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc     1500

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     1560

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     1620

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     1680

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg     1740

tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     1800

tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa     1860

gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta actccgccca     1920

tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt     1980

ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag tagtgaggag     2040

gcttttttgg aggcctaggc ttttgcaaaa agctcccggg agcttgtata tccattttcg     2100

gatctgatca agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg     2160

caggttctcc ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa     2220

tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg     2280

tcaagaccga cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt     2340

ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa     2400

gggactggct gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc     2460

ctgccgagaa agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg     2520

ctacctgccc attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg     2580

aagccggtct tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg     2640

aactgttcgc caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg     2700

gcgatgcctg cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact     2760

gtggccggct gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg     2820

ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc     2880

ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga gcgggactct     2940

ggggttcgaa atgaccgacc aagcgacgcc caacctgcca tcacgagatt tcgattccac     3000

cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat     3060

cctccagcgc ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc     3120

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     3180

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc     3240

gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg     3300

ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg     3360

tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc     3420

gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt     3480

gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct     3540

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga     3600

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc     3660

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg     3720

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg     3780

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt     3840

tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt     3900

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg     3960

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact     4020

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt     4080

cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct     4140

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac     4200

cgctggtagc ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca     4260

agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta     4320

agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa     4380

atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg     4440

cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg     4500

actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc     4560

aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc     4620

cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa     4680

ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc     4740

cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     4800

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     4860

cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat     4920

ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg     4980

tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc     5040

ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg     5100

aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat     5160

gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg     5220

gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg     5280

ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct     5340

catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac     5400

atttccccga aaagtgccac ctgacgtc                                        5428


<210> 41
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Coding sequence is appended to the 3' end of the last codon of "
      the heavy chain constant region

<400> 41
caccatcacc atcaccatca ccat                                              24


<210> 42
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nuclear localization signal"

<400> 42
Gly Gly Ser Gly Pro Pro Lys Lys Lys Arg Lys Val 
1               5                   10          


<210> 43
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nuclear localization signal"

<400> 43
Pro Lys Lys Lys Arg Lys Val 
1               5           


<210> 44
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nuclear localization signal"

<400> 44
Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210> 45
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nuclear localization signal"


<220>
<221> MOD_RES
<222> (3)..(12)
<223> Any amino acid

<400> 45
Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys Lys Lys 
1               5                   10                  15      


<210> 46
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nuclear localization signal"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 46
Lys Lys Xaa Lys 
1               


<210> 47
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nuclear localization signal"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 47
Lys Arg Xaa Lys 
1               


<210> 48
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nuclear localization signal"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 48
Lys Lys Xaa Arg 
1               


<210> 49
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nuclear localization signal"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 49
Lys Arg Xaa Arg 
1               


<210> 50
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nuclear localization signal"

<400> 50
Ala Val Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Leu Asp 
            20  


<210> 51
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nuclear localization signal"

<400> 51
Met Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala 
1               5                   10                  15      


Lys Lys Leu Ala Lys Glu Val Glu Asn 
            20                  25  


<210> 52
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nuclear localization signal"

<400> 52
Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210> 53
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nuclear localization signal"

<400> 53
Pro Pro Lys Lys Lys Arg Lys Val 
1               5               


<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nuclear localization signal"

<400> 54
Lys Leu Lys Ile Lys Arg Pro Val Lys 
1               5                   


<210> 55
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      mitochondrial localization signal"

<400> 55
Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala Thr Arg 
1               5                   10                  15      


Thr Leu Cys Ser Ser Arg Tyr Leu Leu 
            20                  25  


<210> 56
<211> 728
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light Chain Coding Sequence"

<400> 56
acccaagctg gctagccgcc accatgaaat gggtcacctt tatcagcctg ctgttcctgt       60

tcagcagcgc ctacagcgac gtggtcatga cacagacccc actgagcctg cctgtgtctc      120

tgggagatca ggccagcatc agctgcagat ctagccagag cctggtgtac tccgacggca      180

acacacatct gcactggtat ctgcagaaaa ccggacagag ccccaagctg ctgatctaca      240

aggccagcaa cagattcagc ggcgtgcccg atagattttc cggcagcggc tctggcaccg      300

acttcaccct gaagatctcc agagtggaag ccgaggacct gggcgtgtac ttctgtagcc      360

agtctaccca cgtgccactg acctttggcg ccggaacaaa gctggaactg aagggtgatc      420

cagttgcacc tactgtcctc atcttcccac cagctgctga tcaggtggca actggaacag      480

tcaccatcgt gtgtgtggcg aataaatact ttcccgatgt caccgtcacc tgggaggtgg      540

atggcaccac ccaaacaact ggcatcgaga acagtaaaac accgcagaac tctgcagatt      600

ctacctacaa cctcagcagc actctgacac tgaccagcac acagtacaac agccacaaag      660

agtacacctg caaggtgacc cagggcacga cctcagtcgt ccagagcttc aacaggggtg      720

actgctag                                                               728


<210> 57
<211> 1388
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy Chain Coding Sequence"

<400> 57
acccaagctg gctagccgcc accatgaaat gggtcacctt tatcagcctg ctgttcctgt       60

tcagcagcgc ctactctgag gtccagctgc agcaatctgg ccccgagctt gtgaaacctg      120

gcgcctctgt gaagatcagc tgtcaggcca gcggctacac cttcaccgac tactacatga      180

actgggttaa gcagagccac ggcaagcggc tggaatggat cggcgacatc aaccccaaca      240

atggcggcac cgcctacaac cagaagttca agggcaaagc cacactgacc gtggacagaa      300

gcagcagcac agcctacatg gaagtgcgga gcctgaccag cgaagatagc gccgtgtact      360

tctgtgccct gctggcctat tggggccagg gaacactggt tacagtgtcc gctgctaaaa      420

cgacaccccc atctgtctat ccactggccc ctggatctgc tgcccaaact aactccatgg      480

tgaccctggg atgcctggtc aagggctatt tccctgagcc agtgacagtg acctggaact      540

ctggatccct gtccagcggt gtgcacacct tcccagctgt cctgcagtct gacctctaca      600

ctctgagcag ctcagtgact gtcccctcca gcacctggcc cagcgagacc gtcacctgca      660

acgttgccca cccggccagc agcaccaagg tggacaagaa aattgtgccc agggattgtg      720

gttgtaagcc ttgcatatgt acagtcccag aagtatcatc tgtcttcatc ttccccccaa      780

agcccaagga tgtgctcacc attactctga ctcctaaggt cacgtgtgtt gtggtagaca      840

tcagcaagga tgatcccgag gtccagttca gctggtttgt agatgatgtg gaggtgcaca      900

cagctcagac gcaaccccgg gaggagcagt tcaacagcac tttccgctca gtcagtgaac      960

ttcccatcat gcaccaggac tggctcaatg gcaaggagtt caaatgcagg gtcaacagtg     1020

cagctttccc tgcccccatc gagaaaacca tctccaaaac caaaggcaga ccgaaggctc     1080

cgcaggtgta caccattcca cctcccaagg agcagatggc caaggataaa gtcagtctga     1140

cctgcatgat aacagacttc ttccctgaag acattactgt ggagtggcag tggaatgggc     1200

agccagcgga gaactacaag aacactcagc ccatcatgga cacagatggc tcttacttcg     1260

tctacagcaa gctcaatgtg cagaagagca actgggaggc aggaaatact ttcacctgct     1320

ctgtgttaca tgagggcctg cacaaccacc atactgagaa gagcctctcc cactctcctg     1380

gtaaatga                                                              1388


<210> 58
<211> 753
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
       Light Chain Coding Sequence"

<400> 58
acccaagctg gctagccgcc accatgaaat gggtcacctt tatcagcctg ctgttcctgt       60

tcagcagcgc ctacagcgac gtggtcatga cacagacccc actgagcctg cctgtgtctc      120

tgggagatca ggccagcatc agctgcagat ctagccagag cctggtgtac tccgacggca      180

acacacatct gcactggtat ctgcagaaaa ccggacagag ccccaagctg ctgatctaca      240

aggccagcaa cagattcagc ggcgtgcccg atagattttc cggcagcggc tctggcaccg      300

acttcaccct gaagatctcc agagtggaag ccgaggacct gggcgtgtac ttctgtagcc      360

agtctaccca cgtgccactg acctttggcg ccggaacaaa gctggaactg aagcgggcag      420

atgctgcacc aactgtatcc atcttcccac catccagtga gcagttaaca tctggaggtg      480

cctcagtcgt gtgcttcttg aacaacttct accccaaaga catcaatgtc aagtggaaga      540

ttgatggcag tgaacgacaa aatggcgtcc tgaacagttg gactgatcag gacagcaaag      600

acagcaccta cagcatgagc agcaccctca cgttgaccaa ggacgagtat gaacgacata      660

acagctatac ctgtgaggcc actcacaaga catcaacttc acccattgtc aagagcttca      720

acaggaatga gtgttaggaa ttctgcagat atc                                   753


<210> 59
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Leader peptide that may be present at the N-terminus of a heavy "
      chain

<400> 59
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210> 60
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light Chain"

<400> 60
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr His Leu His Trp Tyr Leu Gln Lys Thr Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210> 61
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light Chain Constant Region"

<400> 61
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         


<210> 62
<211> 455
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy Chain"

<400> 62
Met Gly Trp Ser Trp Val Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Arg Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ala Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Val Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Leu Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
    130                 135                 140                 


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
                165                 170                 175     


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
            180                 185                 190         


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
        195                 200                 205             


Gln Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys 
225                 230                 235                 240 


Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp 
        275                 280                 285             


Asp Val Glu Val His Thr Ala Gln Thr Lys Pro Arg Glu Glu Gln Ile 
    290                 295                 300                 


Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys 
            340                 345                 350         


Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys 
        355                 360                 365             


Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asn Phe Phe Pro Glu Asp 
    370                 375                 380                 


Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys 
385                 390                 395                 400 


Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser 
                405                 410                 415     


Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr 
            420                 425                 430         


Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210> 63
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light Chain"

<400> 63
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val Tyr Ser Asp Gly Asn Thr His Leu His Trp Tyr Leu Gln Lys Thr 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210> 64
<211> 323
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Rabbit IgG"

<400> 64
Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly 
1               5                   10                  15      


Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn 
        35                  40                  45              


Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys 
65                  70                  75                  80  


Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala 
                85                  90                  95      


Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly 
            100                 105                 110         


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        115                 120                 125             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    130                 135                 140                 


Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val 
145                 150                 155                 160 


Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile 
                165                 170                 175     


Arg Val Val Ser Thr Leu Pro Ile Thr His Gln Asp Trp Leu Arg Gly 
            180                 185                 190         


Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile 
        195                 200                 205             


Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val 
    210                 215                 220                 


Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser 
225                 230                 235                 240 


Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu 
                245                 250                 255     


Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala 
            260                 265                 270         


Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Asn Lys Leu Ser Val 
        275                 280                 285             


Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met 
    290                 295                 300                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser 
305                 310                 315                 320 


Pro Gly Lys 
            


<210> 65
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Human IgG"

<400> 65
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 66
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 66
ccgtctgtgc cttctcatct g                                                 21


<210> 67
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 67
agtccaagag tyctcttatg yaagacctt                                         29


<210> 68
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"

<400> 68
cttcgcttca cctctgc                                                      17


<210> 69
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 69
Gly Arg Pro Phe Ser Gly Ser Leu Gly Thr Leu Ser Ser Pro Ser Pro 
1               5                   10                  15      


Ser Ala Val Pro Thr Asp His Gly 
            20                  


<210> 70
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 70
Gly Arg Pro Leu Ser Gly Pro Leu Gly Thr Leu Ser Ser Pro Ser Pro 
1               5                   10                  15      


Ser Ala Val Pro Ala Asp His Gly 
            20                  


<210> 71
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 71
Gly Arg Pro Leu Pro Gly Pro Leu Gly Ala Leu Pro Pro Ala Ser Pro 
1               5                   10                  15      


Pro Val Val Pro Thr Asp His Gly 
            20                  


<210> 72
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 72
Gly Arg Pro Val Ser Gly Pro Phe Gly Thr Leu Pro Ser Pro Ser Ser 
1               5                   10                  15      


Ser Ala Val Pro Ala Asp His Gly 
            20                  


<210> 73
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 73
Gly Arg Pro Val Ser Gly Ser Leu Gly Asp Leu Ser Ser Pro Ser Pro 
1               5                   10                  15      


Ser Ala Val Pro Ala Asp His Gly 
            20                  


