                         SEQUENCE LISTING

<110>  lee, Kelvin
       Zhang, Xiaolin
 
<120>  METHOD TO ALTER CHINESE HAMSTER OVARY CELL LINE STABILITY

<130>  UOD-502WO

<150>  US 62/651,317
<151>  2018-04-02

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  912
<212>  PRT
<213>  Cricetulus griseus

<400>  1

Met Ala Thr Ser Gln Thr Ser Gln Thr Val Ala Ala His Val Pro Phe 
1               5                   10                  15      


Ala Asp Leu Cys Ser Thr Leu Glu Arg Ile Gln Lys Ser Lys Glu Arg 
            20                  25                  30          


Ala Glu Lys Ile Arg His Phe Lys Glu Phe Leu Asp Ser Trp Arg Lys 
        35                  40                  45              


Phe His Asp Ala Leu His Lys Asn Lys Lys Asp Val Thr Asp Ser Phe 
    50                  55                  60                  


Tyr Pro Ala Met Arg Leu Ile Leu Pro Gln Leu Glu Arg Glu Arg Met 
65                  70                  75                  80  


Ala Tyr Gly Ile Lys Glu Thr Met Leu Ala Lys Leu Tyr Ile Glu Leu 
                85                  90                  95      


Leu Asn Leu Pro Arg Glu Gly Lys Asp Ala Leu Lys Leu Leu Asn Tyr 
            100                 105                 110         


Arg Thr Pro Ser Gly Ala Arg Thr Asp Ala Gly Asp Phe Ala Val Ile 
        115                 120                 125             


Ala Tyr Phe Val Leu Lys Pro Arg Cys Leu Gln Lys Gly Ser Leu Thr 
    130                 135                 140                 


Leu Gln Gln Val Asn Glu Leu Leu Asp Leu Val Ala Ser Asn Asn Ser 
145                 150                 155                 160 


Gly Lys Arg Lys Asp Leu Val Lys Lys Ser Leu Leu Gln Leu Ile Thr 
                165                 170                 175     


Gln Ser Ser Ala Leu Glu Gln Lys Trp Leu Ile Arg Met Ile Ile Lys 
            180                 185                 190         


Asp Leu Lys Leu Gly Val Ser Gln Gln Thr Ile Leu Asn Ile Phe His 
        195                 200                 205             


Asn Asp Ala Val Glu Leu His Asn Val Thr Thr Asp Leu Glu Lys Val 
    210                 215                 220                 


Cys Arg Gln Leu His Asp Pro Ala Val Gly Leu Ser Asp Ile Ser Ile 
225                 230                 235                 240 


Thr Leu Phe Ser Ala Phe Lys Pro Met Leu Ala Ala Val Ala Asp Val 
                245                 250                 255     


Glu Arg Val Glu Lys Asp Met Lys Gln Gln Ser Phe Tyr Ile Glu Thr 
            260                 265                 270         


Lys Leu Asp Gly Glu Arg Met Gln Met His Lys Asp Gly Ser Val Tyr 
        275                 280                 285             


Gln Tyr Phe Ser Arg Asn Gly Tyr Asn Tyr Thr Asp Gln Phe Gly Ala 
    290                 295                 300                 


Ser Pro Gln Glu Gly Thr Leu Thr Pro Phe Ile His Asp Ala Phe Arg 
305                 310                 315                 320 


Thr Asp Val Gln Val Cys Ile Leu Asp Gly Glu Met Met Ala Tyr Asn 
                325                 330                 335     


Pro Thr Thr Gln Thr Phe Met Gln Lys Gly Val Lys Phe Asp Ile Lys 
            340                 345                 350         


Arg Met Val Glu Asp Ser Asp Leu Gln Thr Cys Tyr Cys Val Phe Asp 
        355                 360                 365             


Val Leu Met Val Asn Asn Lys Lys Leu Gly Arg Glu Thr Leu Arg Lys 
    370                 375                 380                 


Arg Tyr Asp Ile Leu Asn Ser Thr Phe Thr Pro Ile Gln Gly Arg Ile 
385                 390                 395                 400 


Glu Ile Val Gln Lys Lys Leu Ala Gln Thr Lys Asn Glu Val Val Asp 
                405                 410                 415     


Ala Leu Asn Glu Ala Ile Asp Lys Arg Glu Glu Gly Ile Met Ile Lys 
            420                 425                 430         


His Pro Leu Ser Ile Tyr Lys Pro Asp Lys Arg Gly Glu Gly Trp Leu 
        435                 440                 445             


Lys Ile Lys Pro Glu Tyr Val Ser Gly Leu Met Asp Glu Leu Asp Leu 
    450                 455                 460                 


Leu Ile Val Gly Gly Tyr Trp Gly Lys Gly Ser Arg Gly Gly Met Met 
465                 470                 475                 480 


Ser His Phe Leu Cys Ala Val Ala Glu Lys Pro Pro His Gly Glu Lys 
                485                 490                 495     


Pro Ser Val Phe His Thr Leu Cys Arg Val Gly Ser Gly Tyr Thr Met 
            500                 505                 510         


Lys Glu Leu Tyr Asp Leu Gly Leu Lys Leu Ala Lys Tyr Trp Lys Pro 
        515                 520                 525             


Phe His Lys Lys Ser Pro Pro Ser Ser Ile Leu Cys Gly Thr Glu Lys 
    530                 535                 540                 


Pro Glu Val Tyr Ile Glu Pro Cys Asn Ser Val Ile Val Gln Ile Lys 
545                 550                 555                 560 


Ala Ala Glu Ile Val Pro Ser Asp Met Tyr Lys Thr Gly Thr Thr Leu 
                565                 570                 575     


Arg Phe Pro Arg Ile Glu Lys Ile Arg Asp Asp Lys Glu Trp His Glu 
            580                 585                 590         


Cys Met Thr Leu Gly Asp Leu Glu Glu Leu Arg Gly Lys Ala Ser Gly 
        595                 600                 605             


Lys Leu Ala Thr Lys His Leu His Val Gly Asp Asp Asp Glu Pro Arg 
    610                 615                 620                 


Glu Lys Arg Arg Lys Pro Val Ser Lys Met Lys Lys Thr Ile Gly Ile 
625                 630                 635                 640 


Ile Glu His Leu Lys Ala Pro Asn Leu Ser Asn Ile Ser Lys Val Ser 
                645                 650                 655     


Asn Val Phe Glu Asp Val Glu Phe Cys Val Met Ser Gly Leu Asp Gly 
            660                 665                 670         


Tyr Pro Lys Ser Asp Leu Glu Asn Arg Ile Ala Glu Phe Gly Gly Tyr 
        675                 680                 685             


Ile Val Gln Asn Pro Gly Pro Asp Thr Tyr Cys Val Ile Ala Gly Cys 
    690                 695                 700                 


Glu Asn Ile Arg Val Lys Asn Ile Ile Ser Ser Asp Gln His Asp Val 
705                 710                 715                 720 


Val Lys Pro Glu Trp Leu Leu Glu Cys Phe Lys Thr Lys Thr Cys Val 
                725                 730                 735     


Pro Trp Gln Pro Cys Phe Met Ile His Met Cys Pro Ser Thr Lys Gln 
            740                 745                 750         


His Phe Ala Arg Glu Tyr Asp Cys Tyr Gly Asp Ser Tyr Phe Val Asp 
        755                 760                 765             


Thr Asp Leu Asp Gln Leu Lys Glu Val Phe Leu Gly Ile Lys Lys Ala 
    770                 775                 780                 


Gly Glu His Gln Thr Pro Glu Glu Met Ala Pro Val Ile Ala Asp Leu 
785                 790                 795                 800 


Glu Tyr Arg Tyr Ser Trp Asp His Ser Pro Leu Cys Met Phe Arg His 
                805                 810                 815     


Cys Thr Val Tyr Leu Asp Leu Tyr Ala Val Ile Asn Asp Ser Ser Ser 
            820                 825                 830         


Lys Ile Lys Ala Thr Arg Leu Asp Val Thr Ala Leu Glu Leu Arg Phe 
        835                 840                 845             


His Gly Ala Lys Val Val Ser His Leu Ser Glu Gly Val Ser His Val 
    850                 855                 860                 


Ile Ile Gly Glu Asp Gln Ser Arg Val Ser Asp Phe Lys Val Phe Arg 
865                 870                 875                 880 


Arg Thr Leu Lys Lys Lys Phe Lys Ile Leu Gln Glu Arg Trp Val Thr 
                885                 890                 895     


Asp Ser Val Asp Lys Gly Glu Leu Gln Glu Glu Asn Gln Tyr Leu Leu 
            900                 905                 910         


<210>  2
<211>  608
<212>  PRT
<213>  Cricetulus griseus

<400>  2

Met Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Glu Glu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Ser Pro Asp Pro Gly Gly Glu Tyr Lys Tyr Ser Gly 
            20                  25                  30          


Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Arg Ala Met Phe Asp 
        35                  40                  45              


Ser Gln Gly Glu Asp Glu Val Thr Pro Phe Asp Met Ser Ile Gln Cys 
    50                  55                  60                  


Ile Gln Ser Val Tyr Thr Ser Lys Ile Ile Ser Ser Asn Arg Asp Leu 
65                  70                  75                  80  


Leu Gly Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser Val Asn 
                85                  90                  95      


Phe Lys Asn Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly Ala Lys 
            100                 105                 110         


Arg Val Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Lys Lys His 
        115                 120                 125             


Phe Gln Asp Thr Ile Gly His Gly Ser Asp Tyr Ser Leu Ser Glu Val 
    130                 135                 140                 


Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Val Lys Met Ser 
145                 150                 155                 160 


His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asp Pro His Gly Asn 
                165                 170                 175     


Asp Ser Ala Lys Ala Ser Arg Ala Arg Thr Lys Ala Asn Asp Leu Arg 
            180                 185                 190         


Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Arg Arg Gly Gly 
        195                 200                 205             


Phe Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala Glu Asp 
    210                 215                 220                 


Glu Asp Leu Gly Val His Phe Glu Glu Ser Ser Lys Leu Glu Asp Leu 
225                 230                 235                 240 


Leu Arg Lys Val Arg Ala Lys Glu Thr Lys Lys Arg Val Leu Ser Arg 
                245                 250                 255     


Leu Arg Phe Lys Leu Gly Lys Asp Val Ala Leu Met Val Gly Ile Tyr 
            260                 265                 270         


Asn Leu Ile Gln Lys Ala Asn Lys Pro Phe Pro Val Arg Leu Tyr Arg 
        275                 280                 285             


Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn Val Asn 
    290                 295                 300                 


Thr Gly Ser Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln Thr Tyr 
305                 310                 315                 320 


Gly Ser Arg Gln Ile Val Leu Glu Lys Glu Glu Thr Glu Glu Leu Lys 
                325                 330                 335     


Arg Phe Asp Glu Pro Gly Leu Ile Leu Met Gly Phe Lys Pro Leu Val 
            340                 345                 350         


Met Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val Tyr Pro 
        355                 360                 365             


Glu Glu Ser Leu Val Asn Gly Ser Ser Thr Leu Phe Ser Ala Leu Leu 
    370                 375                 380                 


Thr Lys Cys Leu Glu Lys Glu Val Met Ala Val Cys Arg Tyr Thr Ser 
385                 390                 395                 400 


Arg Lys Asn Val Pro Pro Tyr Phe Val Ala Leu Val Pro Gln Glu Glu 
                405                 410                 415     


Glu Leu Asp Asp Gln Asn Ile Gln Val Thr Pro Ala Gly Phe Gln Leu 
            420                 425                 430         


Val Phe Leu Pro Tyr Ala Asp Asp Lys Arg Lys Val Pro Phe Thr Glu 
        435                 440                 445             


Lys Val Met Ala Asn Pro Glu Gln Ile Asp Lys Met Lys Ala Ile Val 
    450                 455                 460                 


His Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn Pro Val 
465                 470                 475                 480 


Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp Met Met 
                485                 490                 495     


Glu Ser Glu Gln Val Val Asp Leu Thr Leu Pro Lys Ala Glu Ala Ile 
            500                 505                 510         


Lys Lys Arg Leu Gly Ser Leu Ala Asp Glu Phe Lys Glu Leu Val Tyr 
        515                 520                 525             


Pro Pro Gly Tyr Asn Pro Glu Gly Lys Ala Thr Lys Arg Lys Gln Asp 
    530                 535                 540                 


Asp Glu Gly Ser Ala Ser Lys Lys Pro Lys Val Glu Leu Ser Glu Glu 
545                 550                 555                 560 


Glu Leu Lys Ala His Phe Ala Lys Gly Thr Leu Gly Lys Leu Thr Val 
                565                 570                 575     


Pro Thr Leu Lys Glu Val Cys Lys Ala Tyr Gly Leu Lys Ser Gly Pro 
            580                 585                 590         


Lys Lys Gln Glu Leu Leu Asp Ala Leu Thr Arg His Phe Gln Lys Asn 
        595                 600                 605             


<210>  3
<211>  912
<212>  PRT
<213>  Cricetulus griseus

<400>  3

Met Ala Thr Ser Gln Thr Ser Gln Thr Val Ala Ala His Val Pro Phe 
1               5                   10                  15      


Ala Asp Leu Cys Ser Thr Leu Glu Arg Ile Gln Lys Ser Lys Glu Arg 
            20                  25                  30          


Ala Glu Lys Ile Arg His Phe Lys Glu Phe Leu Asp Ser Trp Arg Lys 
        35                  40                  45              


Phe His Asp Ala Leu His Lys Asn Lys Lys Asp Val Thr Asp Ser Phe 
    50                  55                  60                  


Tyr Pro Ala Met Arg Leu Ile Leu Pro Gln Leu Glu Arg Glu Arg Met 
65                  70                  75                  80  


Ala Tyr Gly Ile Lys Glu Thr Met Leu Ala Lys Leu Tyr Ile Glu Leu 
                85                  90                  95      


Leu Asn Leu Pro Arg Glu Gly Lys Asp Ala Leu Lys Leu Leu Asn Tyr 
            100                 105                 110         


Arg Thr Pro Ser Gly Ala Arg Thr Asp Ala Gly Asp Phe Ala Val Ile 
        115                 120                 125             


Ala Tyr Phe Val Leu Lys Pro Arg Cys Leu Gln Lys Gly Ser Leu Thr 
    130                 135                 140                 


Ile Gln Gln Val Asn Glu Leu Leu Asp Leu Val Ala Ser Asn Asn Ser 
145                 150                 155                 160 


Gly Lys Arg Lys Asp Leu Val Lys Lys Ser Leu Leu Gln Leu Ile Thr 
                165                 170                 175     


Gln Ser Ser Ala Leu Glu Gln Lys Trp Leu Ile Arg Met Ile Ile Lys 
            180                 185                 190         


Asp Leu Lys Leu Gly Val Ser Gln Gln Thr Ile Leu Asn Ile Phe His 
        195                 200                 205             


Asn Asp Ala Val Glu Leu His Asn Val Thr Thr Asp Leu Glu Lys Val 
    210                 215                 220                 


Cys Arg Gln Leu His Asp Pro Ala Val Gly Leu Ser Asp Ile Ser Ile 
225                 230                 235                 240 


Thr Leu Phe Ser Ala Phe Lys Pro Met Leu Ala Ala Val Ala Asp Val 
                245                 250                 255     


Glu Arg Val Glu Lys Asp Met Lys Gln Gln Ser Phe Tyr Ile Glu Thr 
            260                 265                 270         


Lys Leu Asp Gly Glu Arg Met Gln Met His Lys Asp Gly Ser Val Tyr 
        275                 280                 285             


Gln Tyr Phe Ser Arg Asn Gly Tyr Asn Tyr Thr Asp Gln Phe Gly Ala 
    290                 295                 300                 


Ser Pro Gln Glu Gly Thr Leu Thr Pro Phe Ile His Asp Ala Phe Arg 
305                 310                 315                 320 


Thr Asp Val Gln Val Cys Ile Leu Asp Gly Glu Met Met Ala Tyr Asn 
                325                 330                 335     


Pro Thr Thr Gln Thr Phe Met Gln Lys Gly Val Lys Phe Asp Ile Lys 
            340                 345                 350         


Arg Met Val Glu Asp Ser Asp Leu Gln Thr Cys Tyr Cys Val Phe Asp 
        355                 360                 365             


Val Leu Met Val Asn Asn Lys Lys Leu Gly Arg Glu Thr Leu Arg Lys 
    370                 375                 380                 


Arg Tyr Asp Ile Leu Asn Ser Thr Phe Thr Pro Ile Gln Gly Arg Ile 
385                 390                 395                 400 


Glu Ile Val Gln Lys Lys Leu Ala Gln Thr Lys Asn Glu Val Val Asp 
                405                 410                 415     


Ala Leu Asn Glu Ala Ile Asp Lys Arg Glu Glu Gly Ile Met Ile Lys 
            420                 425                 430         


His Pro Leu Ser Ile Tyr Lys Pro Asp Lys Arg Gly Glu Gly Trp Leu 
        435                 440                 445             


Lys Ile Lys Pro Glu Tyr Val Ser Gly Leu Met Asp Glu Leu Asp Leu 
    450                 455                 460                 


Leu Ile Val Gly Gly Tyr Trp Gly Lys Gly Ser Arg Gly Gly Met Met 
465                 470                 475                 480 


Ser His Phe Leu Cys Ala Val Ala Glu Lys Pro Pro His Gly Glu Lys 
                485                 490                 495     


Pro Ser Val Phe His Thr Leu Cys Arg Val Gly Ser Gly Tyr Thr Met 
            500                 505                 510         


Lys Glu Leu Tyr Asp Leu Gly Leu Lys Leu Ala Lys Tyr Trp Lys Pro 
        515                 520                 525             


Phe His Lys Lys Ser Pro Pro Ser Ser Ile Leu Cys Gly Thr Glu Lys 
    530                 535                 540                 


Pro Glu Val Tyr Ile Glu Pro Cys Asn Ser Val Ile Val Gln Ile Lys 
545                 550                 555                 560 


Ala Ala Glu Ile Val Pro Ser Asp Met Tyr Lys Thr Gly Thr Thr Leu 
                565                 570                 575     


Arg Phe Pro Arg Ile Glu Lys Ile Arg Asp Asp Lys Glu Trp His Glu 
            580                 585                 590         


Cys Met Thr Leu Gly Asp Leu Glu Glu Leu Arg Gly Lys Ala Ser Gly 
        595                 600                 605             


Lys Leu Ala Thr Lys His Leu His Val Gly Asp Asp Asp Glu Pro Arg 
    610                 615                 620                 


Glu Lys Arg Arg Lys Pro Val Ser Lys Met Lys Lys Thr Ile Gly Ile 
625                 630                 635                 640 


Ile Glu His Leu Lys Ala Pro Asn Leu Ser Asn Ile Ser Lys Val Ser 
                645                 650                 655     


Asn Val Phe Glu Asp Val Glu Phe Cys Val Met Ser Gly Leu Asp Gly 
            660                 665                 670         


Tyr Pro Lys Ser Asp Leu Glu Asn Arg Ile Ala Glu Phe Gly Gly Tyr 
        675                 680                 685             


Ile Val Gln Asn Pro Gly Pro Asp Thr Tyr Cys Val Ile Ala Gly Cys 
    690                 695                 700                 


Glu Asn Ile Arg Val Lys Asn Ile Ile Ser Ser Asp Gln His Asp Val 
705                 710                 715                 720 


Val Lys Pro Glu Trp Leu Leu Glu Cys Phe Lys Thr Lys Thr Cys Val 
                725                 730                 735     


Pro Trp Gln Pro Arg Phe Met Ile His Met Cys Pro Ser Thr Lys Gln 
            740                 745                 750         


His Phe Ala Arg Glu Tyr Asp Cys Tyr Gly Asp Ser Tyr Phe Val Asp 
        755                 760                 765             


Thr Asp Leu Asp Gln Leu Lys Glu Val Phe Leu Gly Ile Lys Lys Ala 
    770                 775                 780                 


Gly Glu His Gln Thr Pro Glu Glu Met Ala Pro Val Ile Ala Asp Leu 
785                 790                 795                 800 


Glu Tyr Arg Tyr Ser Trp Asp His Ser Pro Leu Cys Met Phe Arg His 
                805                 810                 815     


Cys Thr Val Tyr Leu Asp Leu Tyr Ala Val Ile Asn Asp Ser Ser Ser 
            820                 825                 830         


Lys Ile Lys Ala Thr Arg Leu Asp Val Thr Ala Leu Glu Leu Arg Phe 
        835                 840                 845             


His Gly Ala Lys Val Val Ser His Leu Ser Glu Gly Val Ser His Val 
    850                 855                 860                 


Ile Ile Gly Glu Asn Gln Ser Arg Val Ser Asp Phe Lys Val Phe Arg 
865                 870                 875                 880 


Arg Thr Leu Lys Lys Lys Phe Lys Ile Leu Gln Glu Arg Trp Val Thr 
                885                 890                 895     


Asp Ser Val Asp Lys Gly Glu Leu Gln Glu Glu Asn Gln Tyr Leu Leu 
            900                 905                 910         


<210>  4
<211>  608
<212>  PRT
<213>  Cricetulus griseus

<400>  4

Met Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Glu Glu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Ser Pro Asp Pro Gly Gly Glu Tyr Lys Tyr Ser Gly 
            20                  25                  30          


Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Arg Ala Met Phe Asp 
        35                  40                  45              


Ser Gln Gly Glu Asp Glu Val Thr Pro Phe Asp Met Ser Ile Gln Cys 
    50                  55                  60                  


Ile Gln Ser Val Tyr Thr Ser Lys Ile Ile Ser Ser Asn Arg Asp Leu 
65                  70                  75                  80  


Leu Gly Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser Val Asn 
                85                  90                  95      


Phe Lys Asn Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly Ala Lys 
            100                 105                 110         


Arg Val Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Lys Lys His 
        115                 120                 125             


Phe Gln Asp Thr Ile Gly His Gly Ser Asp Tyr Ser Leu Ser Glu Val 
    130                 135                 140                 


Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Val Lys Met Ser 
145                 150                 155                 160 


His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asp Pro His Gly Asn 
                165                 170                 175     


Asp Ser Ala Lys Ala Ser Arg Ala Arg Thr Lys Ala Asn Asp Leu Arg 
            180                 185                 190         


Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Arg Arg Gly Gly 
        195                 200                 205             


Phe Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala Glu Asp 
    210                 215                 220                 


Glu Asp Leu Gly Val His Phe Glu Glu Ser Ser Lys Leu Glu Asp Leu 
225                 230                 235                 240 


Leu Arg Lys Val Arg Ala Lys Glu Thr Lys Lys Arg Val Leu Ser Arg 
                245                 250                 255     


Leu Arg Phe Lys Leu Gly Lys Asp Val Ala Leu Met Val Gly Ile Tyr 
            260                 265                 270         


Asn Leu Ile Gln Lys Ala Asn Lys Pro Phe Pro Val Arg Leu Tyr Arg 
        275                 280                 285             


Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn Val Asn 
    290                 295                 300                 


Thr Gly Ser Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln Thr Tyr 
305                 310                 315                 320 


Gly Ser Arg Gln Ile Val Leu Glu Lys Glu Glu Thr Glu Glu Leu Lys 
                325                 330                 335     


Arg Phe Asp Glu Pro Gly Leu Ile Leu Met Gly Phe Lys Pro Leu Val 
            340                 345                 350         


Met Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val Tyr Pro 
        355                 360                 365             


Glu Glu Ser Leu Val Asn Gly Ser Ser Thr Leu Phe Ser Ala Leu Leu 
    370                 375                 380                 


Thr Lys Cys Leu Glu Lys Glu Val Met Ala Val Cys Arg Tyr Thr Ser 
385                 390                 395                 400 


Arg Lys Asn Val Pro Pro Tyr Phe Val Ala Leu Val Pro Gln Glu Glu 
                405                 410                 415     


Glu Leu Asp Asp Gln Asn Ile Gln Val Thr Pro Ala Gly Phe Gln Leu 
            420                 425                 430         


Val Phe Leu Pro Tyr Ala Asp Asp Lys Arg Lys Val Pro Phe Thr Glu 
        435                 440                 445             


Lys Val Met Ala Asn Pro Glu Gln Ile Asp Lys Met Lys Ala Ile Val 
    450                 455                 460                 


His Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn Pro Val 
465                 470                 475                 480 


Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp Met Met 
                485                 490                 495     


Glu Ser Glu Gln Val Val Asp Leu Thr Leu Pro Lys Ala Glu Ala Ile 
            500                 505                 510         


Lys Lys Arg Leu Gly Ser Leu Ala Asp Glu Phe Lys Glu Leu Val Tyr 
        515                 520                 525             


Pro Pro Gly Tyr Asn Pro Glu Gly Lys Ala Thr Lys Arg Lys Gln Asp 
    530                 535                 540                 


Asp Glu Gly Ser Ala Ser Lys Lys Pro Lys Val Glu Leu Ser Glu Glu 
545                 550                 555                 560 


Glu Leu Lys Ala His Phe Ala Lys Gly Thr Leu Gly Lys Leu Thr Val 
                565                 570                 575     


Pro Thr Leu Lys Glu Val Cys Lys Ala Tyr Gly Leu Lys Ser Gly Pro 
            580                 585                 590         


Lys Lys Gln Glu Leu Leu Asp Ala Leu Thr Arg His Phe His Lys Asn 
        595                 600                 605             


<210>  5
<211>  2739
<212>  DNA
<213>  Cricetulus griseus

<400>  5
atggctacct cacaaacttc acaaactgtt gcagctcatg tcccctttgc ggatttatgt       60

tccacattag aacgaataca gaaaagtaaa gaacgtgcag aaaagatcag gcactttaag      120

gaatttttag attcttggag aaaatttcat gatgcccttc ataagaacaa gaaagatgtt      180

acagactctt tttacccagc aatgagactt attcttcctc agttagaaag agagaggatg      240

gcttatggaa tcaaagaaac catgcttgct aagctttaca ttgaattgct gaatttacca      300

agagaaggca aggatgccct gaagctcctg aattatcgaa cacctagtgg agctcgcacg      360

gatgctgggg actttgcagt gatcgcatac ttcgttttga agccaaggtg cttacagaaa      420

ggaagcttaa ctctacagca ggtaaatgaa ctcttagact tagtcgccag caataattct      480

ggcaaaagaa aagacctagt gaaaaagagc ctccttcagt taataaccca gagttcagcc      540

cttgagcaaa aatggctgat tcgtatgatt attaaggact tgaagcttgg tgtcagtcaa      600

caaactatac ttaacatttt tcataatgat gcagttgagt tgcacaacgt caccacagac      660

ctggaaaagg tctgtaggca gctacacgac cccgctgtag ggctcagtga tatctctatc      720

actctgtttt ctgcctttaa gccaatgctt gctgctgtag cagatgtgga acgcgtggag      780

aaggacatga agcagcagag tttctacatc gaaaccaagc tggacgggga acgcatgcag      840

atgcacaaag atgggtcggt gtatcagtac ttctccagaa acggctataa ctacactgat      900

cagtttggtg catctccaca ggaaggcact ctcaccccat tcattcatga tgcgttccgg      960

acagacgtgc aagtatgcat cctcgatggt gagatgatgg cctacaaccc gaccacacag     1020

actttcatgc aaaagggggt caaatttgat atcaaaagga tggtggaaga ttccgaccta     1080

cagacatgtt actgtgtttt tgatgtgttg atggttaata ataagaagct agggcgtgag     1140

actctgagaa agaggtatga tatccttaat agtactttta cacccatcca aggtcgaata     1200

gaaatagtac agaaaaagct agctcagacg aagaacgaag tagtagatgc attaaacgaa     1260

gccatagata agagagaaga aggcatcatg atcaaacacc ctctgtccat ctacaagcca     1320

gacaaaagag gtgaagggtg gctaaaaatt aaaccagagt atgtcagtgg attaatggat     1380

gaattagacc tcctaattgt ggggggctac tgggggaaag gttcacgagg tggcatgatg     1440

tctcactttt tgtgtgcagt ggcagagaag ccccctcatg gtgagaagcc atctgtattc     1500

catactctgt gtcgtgttgg gtcgggatac accatgaaag aactctatga tcttggcttg     1560

aaattggcca aatactggaa gccctttcat aagaaatccc caccgagtag tattttatgt     1620

ggaacagaga agccggaagt ctacattgag ccctgtaact ctgttattgt tcagattaag     1680

gcagcagaga ttgtccccag tgacatgtac aagaccggca ccaccttgcg cttcccacgt     1740

atcgagaaga tcagagatga caaagagtgg catgaatgca tgactctggg tgacttagaa     1800

gagctgaggg ggaaagcatc tgggaaactt gccacaaaac accttcacgt aggtgacgat     1860

gatgaaccta gagaaaagag gcggaaacct gtctccaaaa tgaagaaaac cattggaatt     1920

attgaacact tgaaagcgcc taacctttct aacataagca aagtttccaa tgtatttgaa     1980

gatgttgagt tttgtgttat gagtgggttg gatggttatc ccaagtctga cctggagaac     2040

agaattgcag aatttggtgg ttatatagtg cagaatccag gcccagacac atactgtgtg     2100

attgcaggct gtgagaacat aagagtgaaa aacattatct cttcagatca acatgatgtt     2160

gtcaagcctg agtggctttt agagtgtttt aaaacaaaaa cgtgtgtgcc atggcaaccc     2220

tgctttatga ttcacatgtg cccatcaaca aagcagcatt ttgcccgtga atatgattgc     2280

tatggcgata gctattttgt tgatacagat ttggatcaac tgaaagaagt gtttttagga     2340

attaagaaag caggtgagca tcagactccg gaagagatgg cccctgtgat tgctgaccta     2400

gaatatcgtt attcttggga ccactctcct ctctgtatgt ttcgacactg cactgtttat     2460

ctggacctgt atgctgttat taatgactcg agttccaaaa tcaaagcaac gaggttagat     2520

gtgacagcac ttgagctgcg gtttcatgga gccaaggtag tgtcccactt atctgagggg     2580

gtatctcatg taatcatcgg ggaagatcag agccgagttt cggacttcaa agttttcaga     2640

agaactctta agaagaagtt taagatcctt caagaacgtt gggtgactga ttcagtagac     2700

aagggtgaac tacaggagga aaaccagtat ttgctttag                            2739


<210>  6
<211>  1827
<212>  DNA
<213>  Cricetulus griseus

<400>  6
atgtcagggt gggaatccta ctacaaaacc gagggtgagg aagaggaaga agaggaggag       60

agccctgacc caggtggaga atataaatat tcaggaagag atagtttgat ttttctggtt      120

gatgcctcca gggctatgtt tgactctcag ggtgaagatg aagttacacc ttttgatatg      180

agcatccagt gtatccagag tgtgtacacc agtaagatca taagcagcaa ccgagatctc      240

ttgggagtgg tgttctatgg taccgagaaa gacaaaaact cagtgaattt caaaaatatt      300

tatgtcttac aagagttgga taacccaggt gctaaacgtg tgctagagct tgaccagttt      360

aagggacaac agggaaaaaa acatttccaa gacacaattg gccatggatc tgattactcc      420

ttaagtgaag tgctctgggt ctgtgccaac ctcttcagtg acgtccaggt caagatgagt      480

cacaagagga tcatgctctt cacaaatgaa gatgatccac atggcaatga cagtgccaaa      540

gccagccggg ccaggaccaa agctaatgat ctccgtgaca ctgggatctt ccttgacttg      600

atgcatctga agagacgagg gggctttgac atatccttgt tctacagaga catcatcagc      660

atagctgagg atgaggatct cggggttcac tttgaggaat caagcaagct ggaagacctg      720

ctaaggaagg ttcgcgccaa ggaaaccaaa aagcgagtac tgtccaggtt aaggtttaag      780

cttggtaaag acgtagcact catggtgggc atctataact tgatccagaa agctaacaag      840

ccttttccag tgaggctcta tcgagaaaca aatgaaccag tgaaaaccaa gactaggact      900

tttaatgtaa acacgggcag tctgctcctg cctagtgata ccaaacggtc tcagacctat      960

gggagtcgtc aaattgtgct agagaaagag gaaacagagg agctgaagcg gtttgatgag     1020

ccgggtttga tccttatggg ctttaagccc ttggtaatgc tgaagaagca ccactacctg     1080

aggccttccc tgtttgtgta cccagaggag tccctggtaa acgggagctc aaccttgttc     1140

agtgctctgc tcaccaagtg tctggagaag gaggtcatgg cagtgtgtag atacacatcc     1200

cgaaagaacg tgccccctta ttttgtggct ttggtgccac aggaagagga actggatgat     1260

cagaatattc aggtgacgcc agcaggcttc cagcttgtct tcctccccta tgctgatgac     1320

aagcggaagg tgccctttac tgagaaagtg atggccaacc ccgagcagat agacaagatg     1380

aaagctattg ttcataagct tcgctttaca tacaggagtg acagttttga gaatccagtg     1440

ctgcagcagc acttccggaa cctggaggcc cttgctttgg atatgatgga gtctgagcaa     1500

gtggtagatc tgacactgcc caaggctgaa gccataaaga aaagactggg ctccctggct     1560

gatgagttta aagagcttgt ctacccccct gggtataatc ctgagggaaa agctaccaag     1620

agaaaacaag atgatgaagg ttctgcaagt aaaaagccca aggtagagtt atcagaagaa     1680

gagctgaagg cccattttgc caagggcaca ctgggcaagc taactgtgcc tacactaaag     1740

gaggtctgta aggcctatgg gcttaagagt ggaccgaaga agcaggaact gctagatgct     1800

ctcaccagac acttccagaa gaactga                                         1827


<210>  7
<211>  2739
<212>  DNA
<213>  Cricetulus griseus

<400>  7
atggctacct cacaaacttc acaaactgtt gcagctcatg tcccctttgc ggatttatgt       60

tccacattag aacgaataca gaaaagtaaa gaacgtgcag aaaagatcag gcactttaag      120

gaatttttag attcttggag aaaatttcat gatgcccttc ataagaacaa gaaagatgtt      180

acagactctt tttacccagc aatgagactt attcttcctc agttagaaag agagaggatg      240

gcttatggaa tcaaagaaac catgcttgct aagctttaca ttgaattgct gaatttacca      300

agagaaggca aggatgccct gaagctcctg aattatcgaa cacctagtgg agctcgcacg      360

gatgctgggg actttgcagt gatcgcatac ttcgttttga agccaaggtg cttacagaaa      420

ggaagcttaa ctatacagca ggtaaatgaa ctcttagact tagtcgccag caataattct      480

ggcaaaagaa aagacctagt gaaaaagagc ctccttcagt taataaccca gagttcagcc      540

cttgagcaaa aatggctgat tcgtatgatt attaaggact tgaagcttgg tgtcagtcaa      600

caaactatac ttaacatttt tcataatgat gcagttgagt tgcacaacgt caccacagac      660

ctggaaaagg tctgtaggca gctacacgac cccgctgtag ggctcagtga tatctctatc      720

actctgtttt ctgcctttaa gccaatgctc gctgctgtag cagatgtgga acgcgtggag      780

aaggacatga agcagcagag tttctacatc gaaaccaagc tggacgggga acgcatgcag      840

atgcacaaag atgggtcggt gtatcagtac ttctccagaa atggctataa ctacactgat      900

cagtttggtg catctccaca ggaaggcact ctcaccccat tcattcatga tgcgttccgg      960

acagacgtgc aagtatgcat cctcgatggt gagatgatgg cctacaaccc gaccacacag     1020

actttcatgc aaaagggggt caaatttgat atcaaaagga tggtggaaga ttccgaccta     1080

cagacatgtt actgtgtttt tgatgtgttg atggttaata ataagaagct agggcgtgag     1140

actctgagaa agaggtatga tatccttaat agtactttta cacccatcca aggtcgaata     1200

gaaatagtac agaaaaagct agctcagacg aagaacgaag tagtagatgc attaaacgaa     1260

gccatagata agagagaaga gggcatcatg atcaaacacc ctctgtccat ctacaagcca     1320

gacaaaagag gtgaagggtg gctaaaaatt aaaccagagt atgtcagtgg attaatggat     1380

gaattagacc tcctaattgt ggggggctac tgggggaaag gttcacgagg tggcatgatg     1440

tctcactttt tgtgtgcagt ggcagagaag ccccctcatg gtgagaagcc atctgtattc     1500

catactctgt gtcgtgttgg gtcgggatac accatgaaag aactctatga tcttggcttg     1560

aaattggcca aatactggaa gccctttcat aagaaatccc caccgagtag tattttatgt     1620

ggaacagaga agccggaagt ctacattgag ccctgtaact ctgttattgt tcagattaag     1680

gcagcagaga ttgtccccag tgacatgtac aagaccggca ccaccttgcg cttcccacgt     1740

atcgagaaga tcagagatga caaagagtgg catgaatgca tgactctggg tgacttagaa     1800

gagctgaggg ggaaagcatc tgggaaactt gccacaaaac accttcacgt aggtgacgat     1860

gatgaaccta gagaaaagag gcggaaacct gtctccaaaa tgaagaaaac cattggaatt     1920

attgaacact tgaaagcgcc taacctttct aacataagca aagtttccaa tgtatttgaa     1980

gatgttgagt tttgtgttat gagtgggttg gatggttatc ccaagtctga cctggagaac     2040

agaattgcag aatttggtgg ttatatagtg cagaatccag gcccagacac atactgtgtg     2100

attgcaggct gtgagaacat aagagtgaaa aacattatct cttcagatca acatgatgtt     2160

gtcaagcctg agtggctttt agagtgtttt aaaacaaaaa cgtgtgtgcc atggcaaccc     2220

cgctttatga ttcacatgtg cccatcaaca aagcagcatt ttgcccgtga atatgattgc     2280

tatggcgata gctattttgt tgatacagat ttggatcaac tgaaagaagt gtttttagga     2340

attaagaaag caggtgagca tcagactccg gaagagatgg cccctgtgat tgctgaccta     2400

gaatatcgtt attcttggga ccactctcct ctctgtatgt ttcgacactg cactgtttat     2460

ctggacctgt atgctgttat taatgactcg agttccaaaa tcaaagcaac gaggttagat     2520

gtgacagcac ttgagctgcg gtttcatgga gccaaggtag tgtcccactt atctgagggg     2580

gtatctcatg taatcatcgg ggaaaatcag agccgagttt cggacttcaa agttttcaga     2640

agaactctta agaagaagtt taagatcctt caagaacgtt gggtgactga ttcagtagac     2700

aagggtgaac tacaggagga aaaccagtat ttgctttag                            2739


<210>  8
<211>  1827
<212>  DNA
<213>  Cricetulus griseus

<400>  8
atgtcagggt gggaatccta ctacaaaacc gagggtgagg aagaggaaga agaggaggag       60

agccctgacc caggtggaga atataaatat tcaggaagag atagtttgat ttttctggtt      120

gatgcctcca gggctatgtt tgactctcag ggtgaagatg aagttacacc ttttgatatg      180

agcatccagt gtatccagag tgtgtacacc agtaagatca taagcagcaa ccgagatctc      240

ttgggagtgg tgttctatgg taccgagaaa gacaaaaact cagtgaattt caaaaatatt      300

tatgtcttac aagagttgga taacccaggt gctaaacgtg tgctagagct tgaccagttt      360

aagggacaac agggaaaaaa acatttccaa gacacaattg gccatggatc tgattactcc      420

ttaagtgaag tgctctgggt ctgtgccaac ctcttcagtg acgtccaggt caagatgagt      480

cacaagagga tcatgctctt cacaaatgaa gatgatccac atggcaatga cagtgccaaa      540

gccagccggg ccaggaccaa agctaatgat ctccgtgaca ctgggatctt ccttgacttg      600

atgcatctga agagacgagg gggctttgac atatccttgt tctacagaga catcatcagc      660

atagctgagg atgaggatct cggggttcac tttgaggaat caagcaagct ggaagacctg      720

ctaaggaagg ttcgcgccaa ggaaaccaaa aagcgagtac tgtccaggtt aaggtttaag      780

cttggtaaag acgtagcact catggtgggc atctataact tgatccagaa agctaacaag      840

ccttttccag tgaggctcta tcgagaaaca aatgaaccag tgaaaaccaa gactaggact      900

tttaatgtaa acacgggcag tctgctcctg cctagtgata ccaaacggtc tcagacctat      960

gggagtcgtc aaattgtgct agagaaagag gaaacagagg agctgaagcg gtttgatgag     1020

ccgggtttga tccttatggg ctttaagccc ttggtaatgc tgaagaagca ccactacctg     1080

aggccttccc tgtttgtgta cccagaggag tccctggtaa acgggagctc aaccttgttc     1140

agtgctctgc tcaccaagtg tctggagaag gaggtcatgg cagtgtgtag atacacatcc     1200

cgaaagaacg tgccccctta ttttgtggct ttggtgccac aggaagagga actggatgat     1260

cagaatattc aggtgacgcc agcaggcttc cagcttgtct tcctccccta tgctgatgac     1320

aagcggaagg tgccctttac tgagaaagtg atggccaacc ccgagcagat agacaagatg     1380

aaagctattg ttcataagct tcgctttaca tacaggagtg acagttttga gaatccagtg     1440

ctgcagcagc acttccggaa cctggaggcc cttgctttgg atatgatgga gtctgagcaa     1500

gtggtagatc tgacactgcc caaggctgaa gccataaaga aaagactggg ctccctggct     1560

gatgagttta aagagcttgt ctacccccct gggtataatc ctgagggaaa agctaccaag     1620

agaaaacaag atgatgaagg ttctgcaagt aaaaagccca aggtagagtt atcagaagaa     1680

gagctgaagg cccattttgc caagggcaca ctgggcaagc taactgtgcc tacactaaag     1740

gaggtctgta aggcctatgg gcttaagagt ggaccgaaga agcaggaact gctagatgct     1800

ctcaccagac acttccataa gaactga                                         1827


<210>  9
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
ggagacccaa gctggctagc ccagcaacat ggcgtggt                               38


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
cgccgtagac tctcactgaa ggag                                              24


<210>  11
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
gagatctact ccttcagtga gagt                                              24


<210>  12
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
ggtttaacgg gccctctaga ctatatcata tccagtaaat catccacatc g                51


<210>  13
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
ggagacccaa gctggctagc aaaccaacat gtcagggtgg                             40


<210>  14
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
ggtttaacgg gccctctaga tcagttctta tggaagtgtc tg                          42


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
tgtctccctg ccttgcctta                                                   20


<210>  16
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
gtttaaacgg gccctctaga tcatgacagt ctctttgctt                             40


<210>  17
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
ggagacccaa gctggctagc ttgcttctat ggctacctca                             40


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
gcctggattc tgcactatat                                                   20


<210>  19
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
ggagacccaa gctggctagc ccatccggat ggaagagcct                             40


<210>  20
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
gacatatgac gggtagttct aacgtagtat tctgcaggaa acg                         43


<210>  21
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
atactacgtt agaactaccc gtcatatgtc agactatc                               38


<210>  22
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
ggtttaacgg gccctctaga ttaaaagtag cggtatatga atatatttc                   49


<210>  23
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
ggagacccaa gctggctagc ctaggagaat ggctgtgctc                             40


<210>  24
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
gtttaaacgg gccctctaga tcacagccta aaaaactgag                             40


<210>  25
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
ggagacccaa gctggctagc tagatcttat ggcggcacgg                             40


<210>  26
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
gtttaaacgg gccctctaga tcaggtcagt ggactgtggc                             40


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
tctagagggc ccgtttaaac                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
gctagccagc ttgggtctcc                                                   20


