                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  ANTIGENIC EPSTEIN BARR VIRUS POLYPEPTIDES

<130>  01121-0032-00PCT

<150>  62/652,201
<151>  2018-04-03

<160>  247   

<170>  PatentIn version 3.5

<210>  1
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Glu Ala 
            20                  25                  30          


Ala Leu Leu Val Cys Gln Tyr Thr Ile Gln Ser Leu Ile His Leu Thr 
        35                  40                  45              


Gly Glu Asp Pro Gly Phe Phe Asn Val Glu Ile Pro Glu Phe Pro Phe 
    50                  55                  60                  


Tyr Pro Thr Cys Asn Val Cys Thr Ala Asp Val Asn Val Thr Ile Asn 
65                  70                  75                  80  


Phe Asp Val Gly Gly Lys Lys His Gln Leu Asp Leu Asp Phe Gly Gln 
                85                  90                  95      


Leu Thr Pro His Thr Lys Ala Val Tyr Gln Pro Arg Gly Ala Phe Gly 
            100                 105                 110         


Gly Ser Glu Asn Ala Thr Asn Leu Phe Leu Leu Glu Leu Leu Gly Ala 
        115                 120                 125             


Gly Glu Leu Ala Leu Thr Met Arg Ser Lys Lys Leu Pro Ile Asn Val 
    130                 135                 140                 


Thr Thr Gly Glu Glu Gln Gln Val Ser Leu Glu Ser Val Asp Val Tyr 
145                 150                 155                 160 


Phe Gln Asp Val Phe Gly Thr Met Trp Cys His His Ala Glu Met Gln 
                165                 170                 175     


Asn Pro Val Tyr Leu Ile Pro Glu Thr Val Pro Tyr Ile Lys Trp Asp 
            180                 185                 190         


Asn Cys Asn Ser Thr Asn Ile Thr Ala Val Val Arg Ala Gln Gly Leu 
        195                 200                 205             


Asp Val Thr Leu Pro Leu Ser Leu Pro Thr Ser Ala Gln Asp Ser Asn 
    210                 215                 220                 


Phe Ser Val Lys Thr Glu Met Leu Gly Asn Glu Ile Asp Ile Glu Cys 
225                 230                 235                 240 


Ile Met Glu Asp Gly Glu Ile Ser Gln Val Leu Pro Gly Asp Asn Lys 
                245                 250                 255     


Phe Asn Ile Thr Cys Ser Gly Tyr Glu Ser His Val Pro Ser Gly Gly 
            260                 265                 270         


Ile Leu Thr Ser Thr Ser Pro Val Ala Thr Pro Ile Pro Gly Thr Gly 
        275                 280                 285             


Tyr Ala Tyr Ser Leu Arg Leu Thr Pro Arg Pro Val Ser Arg Phe Leu 
    290                 295                 300                 


Gly Asn Asn Ser Ile Leu Tyr Val Phe Tyr Ser Gly Asn Gly Pro Lys 
305                 310                 315                 320 


Ala Ser Gly Gly Asp Tyr Cys Ile Gln Ser Asn Ile Val Phe Ser Asp 
                325                 330                 335     


Glu Ile Pro Ala Ser Gln Asp Met Pro Thr Asn Thr Thr Asp Ile Thr 
            340                 345                 350         


Tyr Val Gly Asp Asn Ala Thr Tyr Ser Val Pro Met Val Thr Ser Glu 
        355                 360                 365             


Asp Ala Asn Ser Pro Asn Val Thr Val Thr Ala Phe Trp Ala Trp Pro 
    370                 375                 380                 


Asn Asn Thr Glu Thr Asp Phe Lys Cys Lys Trp Thr Leu Thr Ser Gly 
385                 390                 395                 400 


Thr Pro Ser Gly Cys Glu Asn Ile Ser Gly Ala Phe Ala Ser Asn Arg 
                405                 410                 415     


Thr Phe Asp Ile Thr Val Ser Gly Leu Gly Thr Ala Pro Lys Thr Leu 
            420                 425                 430         


Ile Ile Thr Arg Thr Ala Thr Asn Ala Thr Thr Thr Thr His Lys Val 
        435                 440                 445             


Ile Phe Ser Lys Ala Pro Glu Gly Ser Glu Ser Gln Val Arg Gln Gln 
    450                 455                 460                 


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
465                 470                 475                 480 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr 
                485                 490                 495     


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
            500                 505                 510         


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
        515                 520                 525             


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
    530                 535                 540                 


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
545                 550                 555                 560 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp 
                565                 570                 575     


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
            580                 585                 590         


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
        595                 600                 605             


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
    610                 615                 620                 


Ala Lys Ser Arg Lys Ser 
625                 630 


<210>  2
<211>  1032
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly 
    130                 135                 140                 


Ser Ser Asn Gly Ser Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser 
145                 150                 155                 160 


Ser Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
                165                 170                 175     


Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His 
            180                 185                 190         


Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val Pro 
        195                 200                 205             


Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp 
    210                 215                 220                 


Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly 
225                 230                 235                 240 


Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser 
                245                 250                 255     


Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile 
            260                 265                 270         


Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys 
        275                 280                 285             


Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His 
    290                 295                 300                 


Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu 
305                 310                 315                 320 


Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys 
                325                 330                 335     


Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His 
            340                 345                 350         


Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg 
        355                 360                 365             


Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp Tyr 
    370                 375                 380                 


Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn 
385                 390                 395                 400 


Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met 
                405                 410                 415     


Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu 
            420                 425                 430         


Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr Leu 
        435                 440                 445             


Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala 
    450                 455                 460                 


Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys 
465                 470                 475                 480 


Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr 
                485                 490                 495     


Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala 
            500                 505                 510         


Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr 
        515                 520                 525             


Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro 
    530                 535                 540                 


Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu 
545                 550                 555                 560 


Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val 
                565                 570                 575     


Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu 
            580                 585                 590         


Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu 
        595                 600                 605             


Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg 
    610                 615                 620                 


Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu 
625                 630                 635                 640 


Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala Pro 
                645                 650                 655     


Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp Gly 
            660                 665                 670         


Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His 
        675                 680                 685             


Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile 
    690                 695                 700                 


Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val 
705                 710                 715                 720 


Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser 
                725                 730                 735     


Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala Val 
            740                 745                 750         


Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr 
        755                 760                 765             


Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu 
    770                 775                 780                 


Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln 
785                 790                 795                 800 


Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val 
                805                 810                 815     


His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly 
            820                 825                 830         


Leu Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        835                 840                 845             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Ser Gln Val Arg 
    850                 855                 860                 


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
865                 870                 875                 880 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser 
                885                 890                 895     


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
            900                 905                 910         


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
        915                 920                 925             


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
    930                 935                 940                 


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
945                 950                 955                 960 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys 
                965                 970                 975     


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
            980                 985                 990         


His Glu Glu Glu Val Leu Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu 
        995                 1000                 1005             


Ile Gly  Asn Glu Asn His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val 
    1010                 1015                 1020             


Lys Gly  Ile Ala Lys Ser Arg  Lys Ser 
    1025                 1030         


<210>  3
<211>  1001
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu 
            20                  25                  30          


Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu 
        35                  40                  45              


Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser 
    50                  55                  60                  


Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly 
65                  70                  75                  80  


Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser 
                85                  90                  95      


Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu 
            100                 105                 110         


Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly 
145                 150                 155                 160 


His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val 
                165                 170                 175     


Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu 
            180                 185                 190         


Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser 
        195                 200                 205             


Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val 
    210                 215                 220                 


Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val 
225                 230                 235                 240 


Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu 
                245                 250                 255     


Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro 
            260                 265                 270         


His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala 
        275                 280                 285             


Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser 
    290                 295                 300                 


Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu 
305                 310                 315                 320 


His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu 
                325                 330                 335     


Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp 
            340                 345                 350         


Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His 
        355                 360                 365             


Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr 
    370                 375                 380                 


Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu 
385                 390                 395                 400 


Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr 
                405                 410                 415     


Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His 
            420                 425                 430         


Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala 
        435                 440                 445             


Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys 
    450                 455                 460                 


Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu 
465                 470                 475                 480 


Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu 
                485                 490                 495     


Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr 
            500                 505                 510         


Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val 
        515                 520                 525             


Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr 
    530                 535                 540                 


Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu 
545                 550                 555                 560 


Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln 
                565                 570                 575     


Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu 
            580                 585                 590         


Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr 
        595                 600                 605             


Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala 
    610                 615                 620                 


Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp 
625                 630                 635                 640 


Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp 
                645                 650                 655     


His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met 
            660                 665                 670         


Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu 
        675                 680                 685             


Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser 
    690                 695                 700                 


Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala 
705                 710                 715                 720 


Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg 
                725                 730                 735     


Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp 
            740                 745                 750         


Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val 
        755                 760                 765             


Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His 
    770                 775                 780                 


Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala 
785                 790                 795                 800 


Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser Gly Gly Gly Ser 
                805                 810                 815     


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Ser Gln Val 
            820                 825                 830         


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
        835                 840                 845             


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
    850                 855                 860                 


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
865                 870                 875                 880 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
                885                 890                 895     


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
            900                 905                 910         


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
        915                 920                 925             


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
    930                 935                 940                 


Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
945                 950                 955                 960 


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
                965                 970                 975     


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
            980                 985                 990         


Lys Gly Ile Ala Lys Ser Arg Lys  Ser 
        995                 1000     


<210>  4
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly 
    130                 135                 140                 


Ser Ser Asn Gly Ser Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser 
145                 150                 155                 160 


Ser Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
                165                 170                 175     


Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His 
            180                 185                 190         


Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val Pro 
        195                 200                 205             


Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp 
    210                 215                 220                 


Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly 
225                 230                 235                 240 


Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser 
                245                 250                 255     


Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile 
            260                 265                 270         


Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys 
        275                 280                 285             


Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His 
    290                 295                 300                 


Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu 
305                 310                 315                 320 


Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys 
                325                 330                 335     


Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His 
            340                 345                 350         


Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg 
        355                 360                 365             


Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp Tyr 
    370                 375                 380                 


Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn 
385                 390                 395                 400 


Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met 
                405                 410                 415     


Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu 
            420                 425                 430         


Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr Leu 
        435                 440                 445             


Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala 
    450                 455                 460                 


Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys 
465                 470                 475                 480 


Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr 
                485                 490                 495     


Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala 
            500                 505                 510         


Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr 
        515                 520                 525             


Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro 
    530                 535                 540                 


Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu 
545                 550                 555                 560 


Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val 
                565                 570                 575     


Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu 
            580                 585                 590         


Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu 
        595                 600                 605             


Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg 
    610                 615                 620                 


Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu 
625                 630                 635                 640 


Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala Pro 
                645                 650                 655     


Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp Gly 
            660                 665                 670         


Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His 
        675                 680                 685             


Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile 
    690                 695                 700                 


Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val 
705                 710                 715                 720 


Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser 
                725                 730                 735     


Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala Val 
            740                 745                 750         


Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr 
        755                 760                 765             


Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu 
    770                 775                 780                 


Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln 
785                 790                 795                 800 


Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val 
                805                 810                 815     


His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly 
            820                 825                 830         


Leu Tyr Glu Glu Arg Ala Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro 
        835                 840                 845             


Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu 
    850                 855                 860                 


Ser Thr Phe Leu Gly Ser Gly Ser Gly Ser Gly Leu Val Pro Arg Gly 
865                 870                 875                 880 


Ser Gly Ala Gly Gly Gly His His His His His His 
                885                 890         


<210>  5
<211>  861
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu 
            20                  25                  30          


Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu 
        35                  40                  45              


Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser 
    50                  55                  60                  


Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly 
65                  70                  75                  80  


Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser 
                85                  90                  95      


Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu 
            100                 105                 110         


Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly 
145                 150                 155                 160 


His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val 
                165                 170                 175     


Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu 
            180                 185                 190         


Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser 
        195                 200                 205             


Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val 
    210                 215                 220                 


Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val 
225                 230                 235                 240 


Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu 
                245                 250                 255     


Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro 
            260                 265                 270         


His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala 
        275                 280                 285             


Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser 
    290                 295                 300                 


Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu 
305                 310                 315                 320 


His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu 
                325                 330                 335     


Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp 
            340                 345                 350         


Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His 
        355                 360                 365             


Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr 
    370                 375                 380                 


Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu 
385                 390                 395                 400 


Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr 
                405                 410                 415     


Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His 
            420                 425                 430         


Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala 
        435                 440                 445             


Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys 
    450                 455                 460                 


Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu 
465                 470                 475                 480 


Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu 
                485                 490                 495     


Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr 
            500                 505                 510         


Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val 
        515                 520                 525             


Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr 
    530                 535                 540                 


Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu 
545                 550                 555                 560 


Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln 
                565                 570                 575     


Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu 
            580                 585                 590         


Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr 
        595                 600                 605             


Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala 
    610                 615                 620                 


Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp 
625                 630                 635                 640 


Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp 
                645                 650                 655     


His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met 
            660                 665                 670         


Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu 
        675                 680                 685             


Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser 
    690                 695                 700                 


Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala 
705                 710                 715                 720 


Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg 
                725                 730                 735     


Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp 
            740                 745                 750         


Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val 
        755                 760                 765             


Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His 
    770                 775                 780                 


Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala 
785                 790                 795                 800 


Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser Gly Tyr Ile Pro Glu Ala 
                805                 810                 815     


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
            820                 825                 830         


Leu Ser Thr Phe Leu Gly Ser Gly Ser Gly Ser Gly Leu Val Pro Arg 
        835                 840                 845             


Gly Ser Gly Ala Gly Gly Gly His His His His His His 
    850                 855                 860     


<210>  6
<211>  863
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly 
    130                 135                 140                 


Ser Ser Asn Gly Ser Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser 
145                 150                 155                 160 


Ser Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
                165                 170                 175     


Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His 
            180                 185                 190         


Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val Pro 
        195                 200                 205             


Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp 
    210                 215                 220                 


Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly 
225                 230                 235                 240 


Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser 
                245                 250                 255     


Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile 
            260                 265                 270         


Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys 
        275                 280                 285             


Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His 
    290                 295                 300                 


Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu 
305                 310                 315                 320 


Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys 
                325                 330                 335     


Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His 
            340                 345                 350         


Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg 
        355                 360                 365             


Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp Tyr 
    370                 375                 380                 


Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn 
385                 390                 395                 400 


Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met 
                405                 410                 415     


Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu 
            420                 425                 430         


Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr Leu 
        435                 440                 445             


Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala 
    450                 455                 460                 


Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys 
465                 470                 475                 480 


Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr 
                485                 490                 495     


Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala 
            500                 505                 510         


Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr 
        515                 520                 525             


Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro 
    530                 535                 540                 


Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu 
545                 550                 555                 560 


Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val 
                565                 570                 575     


Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu 
            580                 585                 590         


Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu 
        595                 600                 605             


Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg 
    610                 615                 620                 


Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu 
625                 630                 635                 640 


Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala Pro 
                645                 650                 655     


Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp Gly 
            660                 665                 670         


Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His 
        675                 680                 685             


Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile 
    690                 695                 700                 


Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val 
705                 710                 715                 720 


Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser 
                725                 730                 735     


Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala Val 
            740                 745                 750         


Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr 
        755                 760                 765             


Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu 
    770                 775                 780                 


Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln 
785                 790                 795                 800 


Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val 
                805                 810                 815     


His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly 
            820                 825                 830         


Leu Tyr Glu Glu Arg Ala Ser Gly Ser Gly Ser Gly Ser Gly Leu Val 
        835                 840                 845             


Pro Arg Gly Ser Gly Ala Gly Gly Gly His His His His His His 
    850                 855                 860             


<210>  7
<211>  832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu 
            20                  25                  30          


Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu 
        35                  40                  45              


Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser 
    50                  55                  60                  


Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly 
65                  70                  75                  80  


Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser 
                85                  90                  95      


Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu 
            100                 105                 110         


Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly 
145                 150                 155                 160 


His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val 
                165                 170                 175     


Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu 
            180                 185                 190         


Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser 
        195                 200                 205             


Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val 
    210                 215                 220                 


Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val 
225                 230                 235                 240 


Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu 
                245                 250                 255     


Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro 
            260                 265                 270         


His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala 
        275                 280                 285             


Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser 
    290                 295                 300                 


Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu 
305                 310                 315                 320 


His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu 
                325                 330                 335     


Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp 
            340                 345                 350         


Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His 
        355                 360                 365             


Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr 
    370                 375                 380                 


Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu 
385                 390                 395                 400 


Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr 
                405                 410                 415     


Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His 
            420                 425                 430         


Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala 
        435                 440                 445             


Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys 
    450                 455                 460                 


Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu 
465                 470                 475                 480 


Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu 
                485                 490                 495     


Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr 
            500                 505                 510         


Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val 
        515                 520                 525             


Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr 
    530                 535                 540                 


Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu 
545                 550                 555                 560 


Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln 
                565                 570                 575     


Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu 
            580                 585                 590         


Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr 
        595                 600                 605             


Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala 
    610                 615                 620                 


Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp 
625                 630                 635                 640 


Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp 
                645                 650                 655     


His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met 
            660                 665                 670         


Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu 
        675                 680                 685             


Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser 
    690                 695                 700                 


Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala 
705                 710                 715                 720 


Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg 
                725                 730                 735     


Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp 
            740                 745                 750         


Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val 
        755                 760                 765             


Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His 
    770                 775                 780                 


Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala 
785                 790                 795                 800 


Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser Gly Ser Gly Ser Gly Leu 
                805                 810                 815     


Val Pro Arg Gly Ser Gly Ala Gly Gly Gly His His His His His His 
            820                 825                 830         


<210>  8
<211>  870
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser 
        835                 840                 845             


Gly Ser Gly Ser Gly Leu Val Pro Arg Gly Ser Gly Ala Gly Gly Gly 
    850                 855                 860                 


His His His His His His 
865                 870 


<210>  9
<211>  852
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu 
                165                 170                 175     


Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu 
            180                 185                 190         


Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala 
        195                 200                 205             


Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile 
    210                 215                 220                 


Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp 
225                 230                 235                 240 


Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val 
                245                 250                 255     


His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser 
            260                 265                 270         


Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro 
        275                 280                 285             


Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu 
    290                 295                 300                 


Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly 
305                 310                 315                 320 


Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu 
                325                 330                 335     


Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp 
            340                 345                 350         


Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala 
        355                 360                 365             


Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr 
    370                 375                 380                 


Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser 
385                 390                 395                 400 


Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln 
                405                 410                 415     


Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu 
            420                 425                 430         


Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe 
        435                 440                 445             


Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu 
    450                 455                 460                 


Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile 
465                 470                 475                 480 


Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly 
                485                 490                 495     


Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu 
            500                 505                 510         


Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala 
        515                 520                 525             


Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly 
    530                 535                 540                 


Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln 
545                 550                 555                 560 


Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val 
                565                 570                 575     


Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu 
            580                 585                 590         


Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile 
        595                 600                 605             


Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe 
    610                 615                 620                 


Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu 
625                 630                 635                 640 


Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser 
                645                 650                 655     


Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp 
            660                 665                 670         


Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp 
        675                 680                 685             


Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser 
    690                 695                 700                 


Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr 
705                 710                 715                 720 


Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys 
                725                 730                 735     


Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln 
            740                 745                 750         


Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu 
        755                 760                 765             


Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr 
    770                 775                 780                 


Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe 
785                 790                 795                 800 


Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val 
                805                 810                 815     


Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser Gly Ser 
            820                 825                 830         


Gly Ser Gly Leu Val Pro Arg Gly Ser Gly Ala Gly Gly Gly His His 
        835                 840                 845             


His His His His 
    850         


<210>  10
<211>  1007
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu 
            20                  25                  30          


Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu 
        35                  40                  45              


Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser 
    50                  55                  60                  


Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly 
65                  70                  75                  80  


Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser 
                85                  90                  95      


Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu 
            100                 105                 110         


Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg 
        115                 120                 125             


Tyr Ala Trp His Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
145                 150                 155                 160 


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
                165                 170                 175     


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
            180                 185                 190         


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
        195                 200                 205             


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
    210                 215                 220                 


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
225                 230                 235                 240 


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
                245                 250                 255     


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
            260                 265                 270         


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
        275                 280                 285             


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
    290                 295                 300                 


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
305                 310                 315                 320 


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
                325                 330                 335     


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
            340                 345                 350         


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
        355                 360                 365             


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
    370                 375                 380                 


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
385                 390                 395                 400 


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
                405                 410                 415     


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
            420                 425                 430         


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
        435                 440                 445             


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
    450                 455                 460                 


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
465                 470                 475                 480 


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
                485                 490                 495     


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
            500                 505                 510         


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
        515                 520                 525             


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
    530                 535                 540                 


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
545                 550                 555                 560 


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
                565                 570                 575     


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
            580                 585                 590         


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
        595                 600                 605             


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
    610                 615                 620                 


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
625                 630                 635                 640 


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
                645                 650                 655     


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
            660                 665                 670         


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
        675                 680                 685             


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
    690                 695                 700                 


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
705                 710                 715                 720 


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
                725                 730                 735     


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
            740                 745                 750         


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
        755                 760                 765             


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
    770                 775                 780                 


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
785                 790                 795                 800 


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
                805                 810                 815     


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
            820                 825                 830         


Gly Ser Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys 
        835                 840                 845             


Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr 
    850                 855                 860                 


Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly 
865                 870                 875                 880 


Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys 
                885                 890                 895     


Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser 
            900                 905                 910         


Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln 
        915                 920                 925             


Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile 
    930                 935                 940                 


Val Asp His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu 
945                 950                 955                 960 


Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp 
                965                 970                 975     


Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr 
            980                 985                 990         


Leu Ala Asp Gln Tyr Val Lys Gly  Ile Ala Lys Ser Arg  Lys Ser 
        995                 1000                 1005         


<210>  11
<211>  881
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu 
                165                 170                 175     


Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu 
            180                 185                 190         


Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala 
        195                 200                 205             


Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile 
    210                 215                 220                 


Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp 
225                 230                 235                 240 


Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val 
                245                 250                 255     


His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser 
            260                 265                 270         


Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro 
        275                 280                 285             


Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu 
    290                 295                 300                 


Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly 
305                 310                 315                 320 


Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu 
                325                 330                 335     


Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp 
            340                 345                 350         


Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala 
        355                 360                 365             


Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr 
    370                 375                 380                 


Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser 
385                 390                 395                 400 


Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln 
                405                 410                 415     


Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu 
            420                 425                 430         


Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe 
        435                 440                 445             


Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu 
    450                 455                 460                 


Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile 
465                 470                 475                 480 


Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly 
                485                 490                 495     


Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu 
            500                 505                 510         


Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala 
        515                 520                 525             


Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly 
    530                 535                 540                 


Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln 
545                 550                 555                 560 


Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val 
                565                 570                 575     


Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu 
            580                 585                 590         


Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile 
        595                 600                 605             


Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe 
    610                 615                 620                 


Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu 
625                 630                 635                 640 


Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser 
                645                 650                 655     


Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp 
            660                 665                 670         


Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp 
        675                 680                 685             


Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser 
    690                 695                 700                 


Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr 
705                 710                 715                 720 


Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys 
                725                 730                 735     


Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln 
            740                 745                 750         


Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu 
        755                 760                 765             


Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr 
    770                 775                 780                 


Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe 
785                 790                 795                 800 


Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val 
                805                 810                 815     


Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser Gly Tyr 
            820                 825                 830         


Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly 
        835                 840                 845             


Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser Gly Ser Gly Ser Gly 
    850                 855                 860                 


Leu Val Pro Arg Gly Ser Gly Ala Gly Gly Gly His His His His His 
865                 870                 875                 880 


His 
    


<210>  12
<211>  899
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser 
        835                 840                 845             


Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
    850                 855                 860                 


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser Gly Ser Gly 
865                 870                 875                 880 


Ser Gly Leu Val Pro Arg Gly Ser Gly Ala Gly Gly Gly His His His 
                885                 890                 895     


His His His 
            


<210>  13
<211>  1021
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu 
                165                 170                 175     


Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu 
            180                 185                 190         


Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala 
        195                 200                 205             


Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile 
    210                 215                 220                 


Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp 
225                 230                 235                 240 


Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val 
                245                 250                 255     


His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser 
            260                 265                 270         


Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro 
        275                 280                 285             


Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu 
    290                 295                 300                 


Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly 
305                 310                 315                 320 


Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu 
                325                 330                 335     


Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp 
            340                 345                 350         


Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala 
        355                 360                 365             


Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr 
    370                 375                 380                 


Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser 
385                 390                 395                 400 


Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln 
                405                 410                 415     


Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu 
            420                 425                 430         


Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe 
        435                 440                 445             


Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu 
    450                 455                 460                 


Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile 
465                 470                 475                 480 


Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly 
                485                 490                 495     


Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu 
            500                 505                 510         


Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala 
        515                 520                 525             


Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly 
    530                 535                 540                 


Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln 
545                 550                 555                 560 


Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val 
                565                 570                 575     


Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu 
            580                 585                 590         


Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile 
        595                 600                 605             


Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe 
    610                 615                 620                 


Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu 
625                 630                 635                 640 


Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser 
                645                 650                 655     


Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp 
            660                 665                 670         


Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp 
        675                 680                 685             


Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser 
    690                 695                 700                 


Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr 
705                 710                 715                 720 


Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys 
                725                 730                 735     


Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln 
            740                 745                 750         


Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu 
        755                 760                 765             


Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr 
    770                 775                 780                 


Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe 
785                 790                 795                 800 


Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val 
                805                 810                 815     


Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser 
            820                 825                 830         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        835                 840                 845             


Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
    850                 855                 860                 


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
865                 870                 875                 880 


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
                885                 890                 895     


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
            900                 905                 910         


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
        915                 920                 925             


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
    930                 935                 940                 


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
945                 950                 955                 960 


His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
                965                 970                 975     


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
            980                 985                 990         


Asp Lys Ile Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
        995                 1000                 1005             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser 
    1010                 1015                 1020     


<210>  14
<211>  1039
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
    850                 855                 860                 


Gly Ser Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys 
865                 870                 875                 880 


Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr 
                885                 890                 895     


Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly 
            900                 905                 910         


Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys 
        915                 920                 925             


Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser 
    930                 935                 940                 


Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln 
945                 950                 955                 960 


Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile 
                965                 970                 975     


Val Asp His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu 
            980                 985                 990         


Gln Trp Tyr Val Ala Glu Gln His  Glu Glu Glu Val Leu  Phe Lys Asp 
        995                 1000                 1005             


Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu 
    1010                 1015                 1020             


Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys 
    1025                 1030                 1035             


Ser 
    


<210>  15
<211>  838
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu 
            20                  25                  30          


Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu 
        35                  40                  45              


Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser 
    50                  55                  60                  


Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly 
65                  70                  75                  80  


Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser 
                85                  90                  95      


Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu 
            100                 105                 110         


Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg 
        115                 120                 125             


Tyr Ala Trp His Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
145                 150                 155                 160 


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
                165                 170                 175     


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
            180                 185                 190         


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
        195                 200                 205             


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
    210                 215                 220                 


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
225                 230                 235                 240 


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
                245                 250                 255     


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
            260                 265                 270         


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
        275                 280                 285             


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
    290                 295                 300                 


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
305                 310                 315                 320 


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
                325                 330                 335     


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
            340                 345                 350         


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
        355                 360                 365             


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
    370                 375                 380                 


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
385                 390                 395                 400 


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
                405                 410                 415     


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
            420                 425                 430         


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
        435                 440                 445             


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
    450                 455                 460                 


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
465                 470                 475                 480 


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
                485                 490                 495     


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
            500                 505                 510         


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
        515                 520                 525             


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
    530                 535                 540                 


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
545                 550                 555                 560 


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
                565                 570                 575     


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
            580                 585                 590         


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
        595                 600                 605             


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
    610                 615                 620                 


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
625                 630                 635                 640 


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
                645                 650                 655     


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
            660                 665                 670         


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
        675                 680                 685             


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
    690                 695                 700                 


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
705                 710                 715                 720 


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
                725                 730                 735     


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
            740                 745                 750         


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
        755                 760                 765             


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
    770                 775                 780                 


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
785                 790                 795                 800 


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser 
                805                 810                 815     


Gly Ser Gly Ser Gly Leu Val Pro Arg Gly Ser Gly Ala Gly Gly Gly 
            820                 825                 830         


His His His His His His 
        835             


<210>  16
<211>  867
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu 
            20                  25                  30          


Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu 
        35                  40                  45              


Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser 
    50                  55                  60                  


Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly 
65                  70                  75                  80  


Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser 
                85                  90                  95      


Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu 
            100                 105                 110         


Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg 
        115                 120                 125             


Tyr Ala Trp His Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
145                 150                 155                 160 


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
                165                 170                 175     


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
            180                 185                 190         


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
        195                 200                 205             


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
    210                 215                 220                 


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
225                 230                 235                 240 


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
                245                 250                 255     


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
            260                 265                 270         


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
        275                 280                 285             


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
    290                 295                 300                 


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
305                 310                 315                 320 


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
                325                 330                 335     


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
            340                 345                 350         


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
        355                 360                 365             


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
    370                 375                 380                 


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
385                 390                 395                 400 


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
                405                 410                 415     


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
            420                 425                 430         


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
        435                 440                 445             


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
    450                 455                 460                 


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
465                 470                 475                 480 


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
                485                 490                 495     


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
            500                 505                 510         


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
        515                 520                 525             


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
    530                 535                 540                 


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
545                 550                 555                 560 


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
                565                 570                 575     


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
            580                 585                 590         


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
        595                 600                 605             


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
    610                 615                 620                 


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
625                 630                 635                 640 


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
                645                 650                 655     


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
            660                 665                 670         


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
        675                 680                 685             


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
    690                 695                 700                 


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
705                 710                 715                 720 


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
                725                 730                 735     


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
            740                 745                 750         


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
        755                 760                 765             


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
    770                 775                 780                 


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
785                 790                 795                 800 


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser 
                805                 810                 815     


Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
            820                 825                 830         


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser Gly Ser Gly 
        835                 840                 845             


Ser Gly Leu Val Pro Arg Gly Ser Gly Ala Gly Gly Gly His His His 
    850                 855                 860                 


His His His 
865         


<210>  17
<211>  1019
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile 
                165                 170                 175     


Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala 
            180                 185                 190         


Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val 
        195                 200                 205             


Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys 
    210                 215                 220                 


Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro 
225                 230                 235                 240 


Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro 
                245                 250                 255     


Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro 
            260                 265                 270         


Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr 
        275                 280                 285             


Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr 
    290                 295                 300                 


Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met 
305                 310                 315                 320 


Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly 
                325                 330                 335     


Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro 
            340                 345                 350         


Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser 
        355                 360                 365             


Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn 
    370                 375                 380                 


Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala 
385                 390                 395                 400 


Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu 
                405                 410                 415     


Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr 
            420                 425                 430         


Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val 
        435                 440                 445             


Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp 
    450                 455                 460                 


Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly 
465                 470                 475                 480 


Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu 
                485                 490                 495     


Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly 
            500                 505                 510         


His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val 
        515                 520                 525             


Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr 
    530                 535                 540                 


Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu 
545                 550                 555                 560 


His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu 
                565                 570                 575     


Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu 
            580                 585                 590         


Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu 
        595                 600                 605             


Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro 
    610                 615                 620                 


Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser 
625                 630                 635                 640 


Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala 
                645                 650                 655     


Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp 
            660                 665                 670         


Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val 
        675                 680                 685             


Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp 
    690                 695                 700                 


Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu 
705                 710                 715                 720 


Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln 
                725                 730                 735     


Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe 
            740                 745                 750         


Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser 
        755                 760                 765             


Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln 
    770                 775                 780                 


Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn 
785                 790                 795                 800 


Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu 
                805                 810                 815     


Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser Gly Gly 
            820                 825                 830         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Ser 
        835                 840                 845             


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
    850                 855                 860                 


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
865                 870                 875                 880 


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
                885                 890                 895     


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
            900                 905                 910         


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
        915                 920                 925             


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
    930                 935                 940                 


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
945                 950                 955                 960 


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
                965                 970                 975     


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
            980                 985                 990         


Ile Glu Leu Ile Gly Asn Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln 
        995                 1000                 1005             


Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys Ser 
    1010                 1015                 


<210>  18
<211>  1025
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
145                 150                 155                 160 


Ala Ser Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val 
                165                 170                 175     


Lys Leu His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro 
            180                 185                 190         


Trp Thr Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu 
        195                 200                 205             


Trp Arg Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg 
    210                 215                 220                 


Tyr Lys Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala 
225                 230                 235                 240 


Glu Pro Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp 
                245                 250                 255     


Ala Ser Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala 
            260                 265                 270         


Cys Met Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly 
        275                 280                 285             


Thr Met Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu 
    290                 295                 300                 


Arg Cys His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe 
305                 310                 315                 320 


Gln Tyr Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys 
                325                 330                 335     


Arg Val Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly 
            340                 345                 350         


Lys Thr Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser 
        355                 360                 365             


Leu Thr Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr 
    370                 375                 380                 


Phe Val His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys 
385                 390                 395                 400 


Asp Met Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg 
                405                 410                 415     


Tyr Val Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg 
            420                 425                 430         


Glu Pro Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser 
        435                 440                 445             


Val Ala Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly 
    450                 455                 460                 


Cys Val Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val 
465                 470                 475                 480 


Leu Lys Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met 
                485                 490                 495     


Gln Ser Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val 
            500                 505                 510         


Lys Met Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala 
        515                 520                 525             


Leu Arg Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly 
    530                 535                 540                 


Leu Ile Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His 
545                 550                 555                 560 


Pro Leu Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile 
                565                 570                 575     


Gly Ser His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln 
            580                 585                 590         


Gly Pro Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser 
        595                 600                 605             


Ala Leu Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu 
    610                 615                 620                 


Ser Gly Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr 
625                 630                 635                 640 


Arg Asp Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln 
                645                 650                 655     


Ala Ala Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu 
            660                 665                 670         


Glu Arg Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val 
        675                 680                 685             


Asp Arg Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr 
    690                 695                 700                 


Phe Ile Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu 
705                 710                 715                 720 


Ala Ser Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile 
                725                 730                 735     


Met Asn Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile 
            740                 745                 750         


Pro Lys Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys 
        755                 760                 765             


Gly Phe Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr 
    770                 775                 780                 


Thr Tyr Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn 
785                 790                 795                 800 


Tyr Phe Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr 
                805                 810                 815     


Asn Gly Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser 
            820                 825                 830         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        835                 840                 845             


Gly Gly Gly Ser Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile 
    850                 855                 860                 


Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn 
865                 870                 875                 880 


Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly 
                885                 890                 895     


Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala 
            900                 905                 910         


Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu 
        915                 920                 925             


Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile 
    930                 935                 940                 


Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn 
945                 950                 955                 960 


Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn 
                965                 970                 975     


Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe 
            980                 985                 990         


Lys Asp Ile Leu Asp Lys Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly 
        995                 1000                 1005             


Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg 
    1010                 1015                 1020             


Lys Ser  
    1025 


<210>  19
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser Ser 
865                 870                 875                 880 


Gly Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Gly Glu Ser Gln Val 
                885                 890                 895     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            900                 905                 910         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        915                 920                 925             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    930                 935                 940                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
945                 950                 955                 960 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                965                 970                 975     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            980                 985                 990         


Gln His Ile Ser Glu Ser Ile Asn  Asn Ile Val Asp His  Ala Ile Lys 
        995                 1000                 1005             


Cys Lys  Asp His Ala Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala 
    1010                 1015                 1020             


Glu Gln  His Glu Glu Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys 
    1025                 1030                 1035             


Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp 
    1040                 1045                 1050             


Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg Lys Ser  
    1055                 1060                 1065 


<210>  20
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Cys 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser Ser 
865                 870                 875                 880 


Gly Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Gly Glu Ser Gln Val 
                885                 890                 895     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            900                 905                 910         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        915                 920                 925             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    930                 935                 940                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
945                 950                 955                 960 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                965                 970                 975     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            980                 985                 990         


Gln His Ile Ser Glu Ser Ile Asn  Asn Ile Val Asp His  Ala Ile Lys 
        995                 1000                 1005             


Ser Lys  Asp His Ala Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala 
    1010                 1015                 1020             


Glu Gln  His Glu Glu Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys 
    1025                 1030                 1035             


Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp 
    1040                 1045                 1050             


Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg Lys Ser  
    1055                 1060                 1065 


<210>  21
<211>  1366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Asp Ser Lys 
865                 870                 875                 880 


Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu Leu Val Val Ser 
                885                 890                 895     


Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Tyr Phe Leu Pro Pro Arg 
            900                 905                 910         


Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala Ile Thr Trp Val Pro 
        915                 920                 925             


Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro Pro Pro Pro Val Asn 
    930                 935                 940                 


Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp Lys Glu Val Lys Leu 
945                 950                 955                 960 


Pro His Trp Thr Pro Thr Leu His Thr Phe Gln Val Pro Gln Asn Tyr 
                965                 970                 975     


Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg Glu Tyr Thr Phe Ser 
            980                 985                 990         


Tyr Lys Gly Cys Cys Phe Tyr Phe  Thr Lys Lys Lys His  Thr Trp Asn 
        995                 1000                 1005             


Gly Cys  Phe Gln Ala Cys Ala  Glu Leu Tyr Pro Cys  Thr Tyr Phe 
    1010                 1015                 1020             


Tyr Gly  Pro Thr Pro Asp Ile  Leu Pro Val Val Thr  Arg Asn Leu 
    1025                 1030                 1035             


Asn Ala  Ile Glu Ser Leu Trp  Val Gly Val Tyr Arg  Val Gly Glu 
    1040                 1045                 1050             


Gly Asn  Trp Thr Ser Leu Asp  Gly Gly Thr Phe Lys  Val Tyr Gln 
    1055                 1060                 1065             


Ile Phe  Gly Ser His Cys Thr  Tyr Val Ser Lys Phe  Ser Thr Val 
    1070                 1075                 1080             


Pro Val  Ser His His Glu Cys  Ser Phe Leu Lys Pro  Cys Leu Cys 
    1085                 1090                 1095             


Val Ser  Gln Arg Ser Asn Ser  Gly Gly Ser Gly Ser  Ala Ser Ser 
    1100                 1105                 1110             


Gly Ala  Ser Ala Ser Gly Ser  Ser Gly Ser Gly Ser  Gly Ser Gly 
    1115                 1120                 1125             


Ser Ser  Ser Ala Ser Ser Gly  Ala Ser Ser Gly Gly  Ala Ser Gly 
    1130                 1135                 1140             


Gly Ser  Gly Gly Ser Gly Gly  Gly Ser Gly Ser Ala  Ser Ser Gly 
    1145                 1150                 1155             


Ala Ser  Ala Ser Gly Ser Ser  Gly Ser Gly Ser Gly  Ser Gly Ser 
    1160                 1165                 1170             


Ser Ser  Ala Ser Ser Gly Ala  Ser Ser Gly Gly Ala  Ser Gly Gly 
    1175                 1180                 1185             


Ser Gly  Gly Ser Gly Glu Ser  Gln Val Arg Gln Gln  Phe Ser Lys 
    1190                 1195                 1200             


Asp Ile  Glu Lys Leu Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln 
    1205                 1210                 1215             


Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser Trp Ser  Tyr Thr His 
    1220                 1225                 1230             


Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu 
    1235                 1240                 1245             


Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn 
    1250                 1255                 1260             


Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys 
    1265                 1270                 1275             


Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu 
    1280                 1285                 1290             


Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
    1295                 1300                 1305             


Lys Cys  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1310                 1315                 1320             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1325                 1330                 1335             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1340                 1345                 1350             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser 
    1355                 1360                 1365     


<210>  22
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser Ser 
865                 870                 875                 880 


Gly Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Gly Glu Ser Gln Val 
                885                 890                 895     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            900                 905                 910         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        915                 920                 925             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    930                 935                 940                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
945                 950                 955                 960 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                965                 970                 975     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            980                 985                 990         


Gln His Ile Ser Glu Ser Ile Asn  Asn Ile Val Asp His  Ala Ile Lys 
        995                 1000                 1005             


Cys Lys  Asp His Ala Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala 
    1010                 1015                 1020             


Glu Gln  His Glu Glu Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys 
    1025                 1030                 1035             


Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp 
    1040                 1045                 1050             


Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg Lys Ser  
    1055                 1060                 1065 


<210>  23
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Cys 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser Ser 
865                 870                 875                 880 


Gly Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Gly Glu Ser Gln Val 
                885                 890                 895     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            900                 905                 910         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        915                 920                 925             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    930                 935                 940                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
945                 950                 955                 960 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                965                 970                 975     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            980                 985                 990         


Gln His Ile Ser Glu Ser Ile Asn  Asn Ile Val Asp His  Ala Ile Lys 
        995                 1000                 1005             


Ser Lys  Asp His Ala Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala 
    1010                 1015                 1020             


Glu Gln  His Glu Glu Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys 
    1025                 1030                 1035             


Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp 
    1040                 1045                 1050             


Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg Lys Ser  
    1055                 1060                 1065 


<210>  24
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Glu Ala 
            20                  25                  30          


Ala Leu Leu Val Cys Gln Tyr Thr Ile Gln Ser Leu Ile His Leu Thr 
        35                  40                  45              


Gly Glu Asp Pro Gly Phe Phe Asn Val Glu Ile Pro Glu Phe Pro Phe 
    50                  55                  60                  


Tyr Pro Thr Cys Asn Val Cys Thr Ala Asp Val Asn Val Thr Ile Asn 
65                  70                  75                  80  


Phe Asp Val Gly Gly Lys Lys His Gln Leu Asp Leu Asp Phe Gly Gln 
                85                  90                  95      


Leu Thr Pro His Thr Lys Ala Val Tyr Gln Pro Arg Gly Ala Phe Gly 
            100                 105                 110         


Gly Ser Glu Asn Ala Thr Asn Leu Phe Leu Leu Glu Leu Leu Gly Ala 
        115                 120                 125             


Gly Glu Leu Ala Leu Thr Met Arg Ser Lys Lys Leu Pro Ile Asn Val 
    130                 135                 140                 


Thr Thr Gly Glu Glu Gln Gln Val Ser Leu Glu Ser Val Asp Val Tyr 
145                 150                 155                 160 


Phe Gln Asp Val Phe Gly Thr Met Trp Cys His His Ala Glu Met Gln 
                165                 170                 175     


Asn Pro Val Tyr Leu Ile Pro Glu Thr Val Pro Tyr Ile Lys Trp Asp 
            180                 185                 190         


Asn Cys Asn Ser Thr Asn Ile Thr Ala Val Val Arg Ala Gln Gly Leu 
        195                 200                 205             


Asp Val Thr Leu Pro Leu Ser Leu Pro Thr Ser Ala Gln Asp Ser Asn 
    210                 215                 220                 


Phe Ser Val Lys Thr Glu Met Leu Gly Asn Glu Ile Asp Ile Glu Cys 
225                 230                 235                 240 


Ile Met Glu Asp Gly Glu Ile Ser Gln Val Leu Pro Gly Asp Asn Lys 
                245                 250                 255     


Phe Asn Ile Thr Cys Ser Gly Tyr Glu Ser His Val Pro Ser Gly Gly 
            260                 265                 270         


Ile Leu Thr Ser Thr Ser Pro Val Ala Thr Pro Ile Pro Gly Thr Gly 
        275                 280                 285             


Tyr Ala Tyr Ser Leu Arg Leu Thr Pro Arg Pro Val Ser Arg Phe Leu 
    290                 295                 300                 


Gly Asn Asn Ser Ile Leu Tyr Val Phe Tyr Ser Gly Asn Gly Pro Lys 
305                 310                 315                 320 


Ala Ser Gly Gly Asp Tyr Cys Ile Gln Ser Asn Ile Val Phe Ser Asp 
                325                 330                 335     


Glu Ile Pro Ala Ser Gln Asp Met Pro Thr Asn Thr Thr Asp Ile Thr 
            340                 345                 350         


Tyr Val Gly Asp Asn Ala Thr Tyr Ser Val Pro Met Val Thr Ser Glu 
        355                 360                 365             


Asp Ala Asn Ser Pro Asn Val Thr Val Thr Ala Phe Trp Ala Trp Pro 
    370                 375                 380                 


Asn Asn Thr Glu Thr Asp Phe Lys Cys Lys Trp Thr Leu Thr Ser Gly 
385                 390                 395                 400 


Thr Pro Ser Gly Cys Glu Asn Ile Ser Gly Ala Phe Ala Ser Asn Arg 
                405                 410                 415     


Thr Phe Asp Ile Thr Val Ser Gly Leu Gly Thr Ala Pro Lys Thr Leu 
            420                 425                 430         


Ile Ile Thr Arg Thr Ala Thr Asn Ala Thr Thr Thr Thr His Lys Val 
        435                 440                 445             


Ile Phe Ser Lys Ala Pro Glu Gly Ser Thr Gln Cys Asn Val Asn Pro 
    450                 455                 460                 


Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg Ser Cys Arg Asn 
465                 470                 475                 480 


Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser Leu Gln Tyr 
                485                 490                 495     


Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val Asn Arg Pro Gly 
            500                 505                 510         


Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg Glu His Ala 
        515                 520                 525             


Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu Thr Asn Asp 
    530                 535                 540                 


Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser Ser Trp Lys 
545                 550                 555                 560 


Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met Glu Ser Asp Val 
                565                 570                 575     


Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp Asp Ser Glu 
            580                 585                 590         


Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp Phe Leu Glu 
        595                 600                 605             


Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala Ser Thr Leu 
    610                 615                 620                 


Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe Ile Phe Asp 
625                 630                 635                 640 


Lys Lys Leu Leu Gly Ile Asp Val 
                645             


<210>  25
<211>  1039
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser 
        835                 840                 845             


Thr Gln Cys Asn Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr 
    850                 855                 860                 


Met His Arg Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu 
865                 870                 875                 880 


Val Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys 
                885                 890                 895     


Asp Val Val Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala 
            900                 905                 910         


Ser Glu Glu Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met 
        915                 920                 925             


Arg Gly Glu Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro 
    930                 935                 940                 


Pro Thr Arg Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala 
945                 950                 955                 960 


Leu Ser Met Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys 
                965                 970                 975     


Ala Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr 
            980                 985                 990         


Leu Thr Gly Asp Phe Leu Glu Glu  Gln Tyr Lys Gly Gln  Arg Asp Leu 
        995                 1000                 1005             


Ala Gly  Lys Ala Ser Thr Leu  Lys Lys Leu Met Asp  Arg His Glu 
    1010                 1015                 1020             


Ala Leu  Gly Glu Phe Ile Phe  Asp Lys Lys Leu Leu  Gly Ile Asp 
    1025                 1030                 1035             


Val 
    


<210>  26
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Glu Ala 
            20                  25                  30          


Ala Leu Leu Val Cys Gln Tyr Thr Ile Gln Ser Leu Ile His Leu Thr 
        35                  40                  45              


Gly Glu Asp Pro Gly Phe Phe Asn Val Glu Ile Pro Glu Phe Pro Phe 
    50                  55                  60                  


Tyr Pro Thr Cys Asn Val Cys Thr Ala Asp Val Asn Val Thr Ile Asn 
65                  70                  75                  80  


Phe Asp Val Gly Gly Lys Lys His Gln Leu Asp Leu Asp Phe Gly Gln 
                85                  90                  95      


Leu Thr Pro His Thr Lys Ala Val Tyr Gln Pro Arg Gly Ala Phe Gly 
            100                 105                 110         


Gly Ser Glu Asn Ala Thr Asn Leu Phe Leu Leu Glu Leu Leu Gly Ala 
        115                 120                 125             


Gly Glu Leu Ala Leu Thr Met Arg Ser Lys Lys Leu Pro Ile Asn Val 
    130                 135                 140                 


Thr Thr Gly Glu Glu Gln Gln Val Ser Leu Glu Ser Val Asp Val Tyr 
145                 150                 155                 160 


Phe Gln Asp Val Phe Gly Thr Met Trp Cys His His Ala Glu Met Gln 
                165                 170                 175     


Asn Pro Val Tyr Leu Ile Pro Glu Thr Val Pro Tyr Ile Lys Trp Asp 
            180                 185                 190         


Asn Cys Asn Ser Thr Asn Ile Thr Ala Val Val Arg Ala Gln Gly Leu 
        195                 200                 205             


Asp Val Thr Leu Pro Leu Ser Leu Pro Thr Ser Ala Gln Asp Ser Asn 
    210                 215                 220                 


Phe Ser Val Lys Thr Glu Met Leu Gly Asn Glu Ile Asp Ile Glu Cys 
225                 230                 235                 240 


Ile Met Glu Asp Gly Glu Ile Ser Gln Val Leu Pro Gly Asp Asn Lys 
                245                 250                 255     


Phe Asn Ile Thr Cys Ser Gly Tyr Glu Ser His Val Pro Ser Gly Gly 
            260                 265                 270         


Ile Leu Thr Ser Thr Ser Pro Val Ala Thr Pro Ile Pro Gly Thr Gly 
        275                 280                 285             


Tyr Ala Tyr Ser Leu Arg Leu Thr Pro Arg Pro Val Ser Arg Phe Leu 
    290                 295                 300                 


Gly Asn Asn Ser Ile Leu Tyr Val Phe Tyr Ser Gly Asn Gly Pro Lys 
305                 310                 315                 320 


Ala Ser Gly Gly Asp Tyr Cys Ile Gln Ser Asn Ile Val Phe Ser Asp 
                325                 330                 335     


Glu Ile Pro Ala Ser Gln Asp Met Pro Thr Asn Thr Thr Asp Ile Thr 
            340                 345                 350         


Tyr Val Gly Asp Asn Ala Thr Tyr Ser Val Pro Met Val Thr Ser Glu 
        355                 360                 365             


Asp Ala Asn Ser Pro Asn Val Thr Val Thr Ala Phe Trp Ala Trp Pro 
    370                 375                 380                 


Asn Asn Thr Glu Thr Asp Phe Lys Cys Lys Trp Thr Leu Thr Ser Gly 
385                 390                 395                 400 


Thr Pro Ser Gly Cys Glu Asn Ile Ser Gly Ala Phe Ala Ser Asn Arg 
                405                 410                 415     


Thr Phe Asp Ile Thr Val Ser Gly Leu Gly Thr Ala Pro Lys Thr Leu 
            420                 425                 430         


Ile Ile Thr Arg Thr Ala Thr Asn Ala Thr Thr Thr Thr His Lys Val 
        435                 440                 445             


Ile Phe Ser Lys Ala Pro Glu Gly Ser Ala Asp Thr Cys Tyr Asn Asp 
    450                 455                 460                 


Val Ala Leu Asp Cys Gly Ile Thr Ser Asn Ser Leu Ala Leu Pro Arg 
465                 470                 475                 480 


Cys Asn Ala Val Tyr Gly Glu Tyr Gly Ser His Gly Asn Val Ala Thr 
                485                 490                 495     


Glu Leu Gln Ala Tyr Ala Lys Leu His Leu Glu Arg Ser Tyr Asp Tyr 
            500                 505                 510         


Leu Leu Ser Ala Ala Tyr Phe Asn Asn Tyr Gln Thr Asn Arg Ala Gly 
        515                 520                 525             


Phe Ser Lys Leu Phe Lys Lys Leu Ser Asp Glu Ala Trp Ser Lys Thr 
    530                 535                 540                 


Ile Asp Ile Ile Lys His Val Thr Lys Arg Gly Asp Lys Met Asn Phe 
545                 550                 555                 560 


Asp Gln His Ser Thr Met Lys Thr Glu Arg Lys Asn Tyr Thr Ala Glu 
                565                 570                 575     


Asn His Glu Leu Glu Ala Leu Ala Lys Ala Leu Asp Thr Gln Lys Glu 
            580                 585                 590         


Leu Ala Glu Arg Ala Phe Tyr Ile His Arg Glu Ala Thr Arg Asn Ser 
        595                 600                 605             


Gln His Leu His Asp Pro Glu Ile Ala Gln Tyr Leu Glu Glu Glu Phe 
    610                 615                 620                 


Ile Glu Asp His Ala Glu Lys Ile Arg Thr Leu Ala Gly His Thr Ser 
625                 630                 635                 640 


Asp Leu Lys Lys Phe Ile Thr Ala Asn Asn Gly His Asp Leu Ser Leu 
                645                 650                 655     


Ala Leu Tyr Val Phe Asp Glu Tyr Leu Gln Lys Thr Val 
            660                 665                 


<210>  27
<211>  1060
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser 
        835                 840                 845             


Ala Asp Thr Cys Tyr Asn Asp Val Ala Leu Asp Cys Gly Ile Thr Ser 
    850                 855                 860                 


Asn Ser Leu Ala Leu Pro Arg Cys Asn Ala Val Tyr Gly Glu Tyr Gly 
865                 870                 875                 880 


Ser His Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His 
                885                 890                 895     


Leu Glu Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn 
            900                 905                 910         


Tyr Gln Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser 
        915                 920                 925             


Asp Glu Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys 
    930                 935                 940                 


Arg Gly Asp Lys Met Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu 
945                 950                 955                 960 


Arg Lys Asn Tyr Thr Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys 
                965                 970                 975     


Ala Leu Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His 
            980                 985                 990         


Arg Glu Ala Thr Arg Asn Ser Gln  His Leu His Asp Pro  Glu Ile Ala 
        995                 1000                 1005             


Gln Tyr  Leu Glu Glu Glu Phe  Ile Glu Asp His Ala  Glu Lys Ile 
    1010                 1015                 1020             


Arg Thr  Leu Ala Gly His Thr  Ser Asp Leu Lys Lys  Phe Ile Thr 
    1025                 1030                 1035             


Ala Asn  Asn Gly His Asp Leu  Ser Leu Ala Leu Tyr  Val Phe Asp 
    1040                 1045                 1050             


Glu Tyr  Leu Gln Lys Thr Val  
    1055                 1060 


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


<210>  29
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Gly Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
            20                  25              


<210>  30
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser 
1               5                   10                  15      


Asn Gly Ser Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser Ser Gly 
            20                  25                  30          


Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
        35                  40                  45      


<210>  31
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Gly Gly Ser Gly Ser Ala Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Ala Gly Gly Ser Gly Gly Ser Gly 
            20                  25      


<210>  32
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Gly Gly Ser Gly Ser Ala Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Glu Ala Ala Ala Lys Ala Ser Gly Gly Ser Gly Gly Ser Gly 
            20                  25                  30          


<210>  33
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Ser Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly 
1               5                   10                  15      


Ser Ser Cys Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly 
            20                  25                  30          


Ala Ser Ser Gly Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Gly 
        35                  40                  45          


<210>  34
<211>  228
<212>  PRT
<213>  Epstein Barr Virus

<400>  34

Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu Leu 
1               5                   10                  15      


Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Tyr Phe Leu 
            20                  25                  30          


Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala Ile Thr 
        35                  40                  45              


Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro Pro Pro 
    50                  55                  60                  


Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp Lys Glu 
65                  70                  75                  80  


Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe Gln Val Pro 
                85                  90                  95      


Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg Glu Tyr 
            100                 105                 110         


Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys Lys Lys His 
        115                 120                 125             


Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr Pro Cys Thr 
    130                 135                 140                 


Tyr Phe Tyr Gly Pro Thr Pro Asp Ile Leu Pro Val Val Thr Arg Asn 
145                 150                 155                 160 


Leu Asn Ala Ile Glu Ser Leu Trp Val Gly Val Tyr Arg Val Gly Glu 
                165                 170                 175     


Gly Asn Trp Thr Ser Leu Asp Gly Gly Thr Phe Lys Val Tyr Gln Ile 
            180                 185                 190         


Phe Gly Ser His Cys Thr Tyr Val Ser Lys Phe Ser Thr Val Pro Val 
        195                 200                 205             


Ser His His Glu Cys Ser Phe Leu Lys Pro Cys Leu Cys Val Ser Gln 
    210                 215                 220                 


Arg Ser Asn Ser 
225             


<210>  35
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  35
tgactgtgaa cgttcgagat ga                                                22


<210>  36
<211>  115
<212>  PRT
<213>  Epstein Barr Virus

<400>  36

Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu Arg Ala Gln His 
1               5                   10                  15      


Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu Val Ser Asn Gln 
            20                  25                  30          


Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser Pro Lys Asn Gly 
        35                  40                  45              


Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly Leu Asn Val Val 
    50                  55                  60                  


Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser Ala Leu Thr Gly 
65                  70                  75                  80  


His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu Tyr Gly Ser Phe 
                85                  90                  95      


Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg Tyr Ala Trp His 
            100                 105                 110         


Arg Gly Gly 
        115 


<210>  37
<211>  662
<212>  PRT
<213>  Epstein Barr Virus

<400>  37

Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His 
1               5                   10                  15      


Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val Pro 
            20                  25                  30          


Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp 
        35                  40                  45              


Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly 
    50                  55                  60                  


Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser 
65                  70                  75                  80  


Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile 
                85                  90                  95      


Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys 
            100                 105                 110         


Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His 
        115                 120                 125             


Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu 
    130                 135                 140                 


Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys 
145                 150                 155                 160 


Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His 
                165                 170                 175     


Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg 
            180                 185                 190         


Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp Tyr 
        195                 200                 205             


Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn 
    210                 215                 220                 


Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met 
225                 230                 235                 240 


Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu 
                245                 250                 255     


Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr Leu 
            260                 265                 270         


Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala 
        275                 280                 285             


Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys 
    290                 295                 300                 


Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr 
305                 310                 315                 320 


Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala 
                325                 330                 335     


Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr 
            340                 345                 350         


Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro 
        355                 360                 365             


Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu 
    370                 375                 380                 


Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val 
385                 390                 395                 400 


Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu 
                405                 410                 415     


Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu 
            420                 425                 430         


Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg 
        435                 440                 445             


Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu 
    450                 455                 460                 


Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala Pro 
465                 470                 475                 480 


Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp Gly 
                485                 490                 495     


Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His 
            500                 505                 510         


Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile 
        515                 520                 525             


Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val 
    530                 535                 540                 


Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser 
545                 550                 555                 560 


Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala Val 
                565                 570                 575     


Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr 
            580                 585                 590         


Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu 
        595                 600                 605             


Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln 
    610                 615                 620                 


Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val 
625                 630                 635                 640 


His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly 
                645                 650                 655     


Leu Tyr Glu Glu Arg Ala 
            660         


<210>  38
<211>  425
<212>  PRT
<213>  Epstein Barr Virus

<400>  38

Glu Ala Ala Leu Leu Val Cys Gln Tyr Thr Ile Gln Ser Leu Ile His 
1               5                   10                  15      


Leu Thr Gly Glu Asp Pro Gly Phe Phe Asn Val Glu Ile Pro Glu Phe 
            20                  25                  30          


Pro Phe Tyr Pro Thr Cys Asn Val Cys Thr Ala Asp Val Asn Val Thr 
        35                  40                  45              


Ile Asn Phe Asp Val Gly Gly Lys Lys His Gln Leu Asp Leu Asp Phe 
    50                  55                  60                  


Gly Gln Leu Thr Pro His Thr Lys Ala Val Tyr Gln Pro Arg Gly Ala 
65                  70                  75                  80  


Phe Gly Gly Ser Glu Asn Ala Thr Asn Leu Phe Leu Leu Glu Leu Leu 
                85                  90                  95      


Gly Ala Gly Glu Leu Ala Leu Thr Met Arg Ser Lys Lys Leu Pro Ile 
            100                 105                 110         


Asn Val Thr Thr Gly Glu Glu Gln Gln Val Ser Leu Glu Ser Val Asp 
        115                 120                 125             


Val Tyr Phe Gln Asp Val Phe Gly Thr Met Trp Cys His His Ala Glu 
    130                 135                 140                 


Met Gln Asn Pro Val Tyr Leu Ile Pro Glu Thr Val Pro Tyr Ile Lys 
145                 150                 155                 160 


Trp Asp Asn Cys Asn Ser Thr Asn Ile Thr Ala Val Val Arg Ala Gln 
                165                 170                 175     


Gly Leu Asp Val Thr Leu Pro Leu Ser Leu Pro Thr Ser Ala Gln Asp 
            180                 185                 190         


Ser Asn Phe Ser Val Lys Thr Glu Met Leu Gly Asn Glu Ile Asp Ile 
        195                 200                 205             


Glu Cys Ile Met Glu Asp Gly Glu Ile Ser Gln Val Leu Pro Gly Asp 
    210                 215                 220                 


Asn Lys Phe Asn Ile Thr Cys Ser Gly Tyr Glu Ser His Val Pro Ser 
225                 230                 235                 240 


Gly Gly Ile Leu Thr Ser Thr Ser Pro Val Ala Thr Pro Ile Pro Gly 
                245                 250                 255     


Thr Gly Tyr Ala Tyr Ser Leu Arg Leu Thr Pro Arg Pro Val Ser Arg 
            260                 265                 270         


Phe Leu Gly Asn Asn Ser Ile Leu Tyr Val Phe Tyr Ser Gly Asn Gly 
        275                 280                 285             


Pro Lys Ala Ser Gly Gly Asp Tyr Cys Ile Gln Ser Asn Ile Val Phe 
    290                 295                 300                 


Ser Asp Glu Ile Pro Ala Ser Gln Asp Met Pro Thr Asn Thr Thr Asp 
305                 310                 315                 320 


Ile Thr Tyr Val Gly Asp Asn Ala Thr Tyr Ser Val Pro Met Val Thr 
                325                 330                 335     


Ser Glu Asp Ala Asn Ser Pro Asn Val Thr Val Thr Ala Phe Trp Ala 
            340                 345                 350         


Trp Pro Asn Asn Thr Glu Thr Asp Phe Lys Cys Lys Trp Thr Leu Thr 
        355                 360                 365             


Ser Gly Thr Pro Ser Gly Cys Glu Asn Ile Ser Gly Ala Phe Ala Ser 
    370                 375                 380                 


Asn Arg Thr Phe Asp Ile Thr Val Ser Gly Leu Gly Thr Ala Pro Lys 
385                 390                 395                 400 


Thr Leu Ile Ile Thr Arg Thr Ala Thr Asn Ala Thr Thr Thr Thr His 
                405                 410                 415     


Lys Val Ile Phe Ser Lys Ala Pro Glu 
            420                 425 


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Cys Leu Val Pro Arg Gly Ser Leu Glu His His His His His His 
1               5                   10                  15  


<210>  40
<211>  154
<212>  PRT
<213>  Aquifex aeolicus

<400>  40

Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly 
1               5                   10                  15      


Ile Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu 
            20                  25                  30          


Gly Ala Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile 
        35                  40                  45              


Thr Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly 
    50                  55                  60                  


Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val 
65                  70                  75                  80  


Leu Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val 
                85                  90                  95      


Ser Lys Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr 
            100                 105                 110         


Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala 
        115                 120                 125             


Gly Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile 
    130                 135                 140                 


Glu Met Ala Asn Leu Phe Lys Ser Leu Arg 
145                 150                 


<210>  41
<211>  156
<212>  PRT
<213>  Escherichia coli

<400>  41

Met Asn Ile Ile Glu Ala Asn Val Ala Thr Pro Asp Ala Arg Val Ala 
1               5                   10                  15      


Ile Thr Ile Ala Arg Phe Asn Asn Phe Ile Asn Asp Ser Leu Leu Glu 
            20                  25                  30          


Gly Ala Ile Asp Ala Leu Lys Arg Ile Gly Gln Val Lys Asp Glu Asn 
        35                  40                  45              


Ile Thr Val Val Trp Val Pro Gly Ala Tyr Glu Leu Pro Leu Ala Ala 
    50                  55                  60                  


Gly Ala Leu Ala Lys Thr Gly Lys Tyr Asp Ala Val Ile Ala Leu Gly 
65                  70                  75                  80  


Thr Val Ile Arg Gly Gly Thr Ala His Phe Glu Tyr Val Ala Gly Gly 
                85                  90                  95      


Ala Ser Asn Gly Leu Ala His Val Ala Gln Asp Ser Glu Ile Pro Val 
            100                 105                 110         


Ala Phe Gly Val Leu Thr Thr Glu Ser Ile Glu Gln Ala Ile Glu Arg 
        115                 120                 125             


Ala Gly Thr Lys Ala Gly Asn Lys Gly Ala Glu Ala Ala Leu Thr Ala 
    130                 135                 140                 


Leu Glu Met Ile Asn Val Leu Lys Ala Ile Lys Ala 
145                 150                 155     


<210>  42

<400>  42
000

<210>  43

<400>  43
000

<210>  44

<400>  44
000

<210>  45

<400>  45
000

<210>  46

<400>  46
000

<210>  47

<400>  47
000

<210>  48

<400>  48
000

<210>  49

<400>  49
000

<210>  50

<400>  50
000

<210>  51

<400>  51
000

<210>  52

<400>  52
000

<210>  53

<400>  53
000

<210>  54

<400>  54
000

<210>  55

<400>  55
000

<210>  56

<400>  56
000

<210>  57

<400>  57
000

<210>  58

<400>  58
000

<210>  59

<400>  59
000

<210>  60

<400>  60
000

<210>  61

<400>  61
000

<210>  62

<400>  62
000

<210>  63

<400>  63
000

<210>  64

<400>  64
000

<210>  65

<400>  65
000

<210>  66

<400>  66
000

<210>  67

<400>  67
000

<210>  68

<400>  68
000

<210>  69

<400>  69
000

<210>  70

<400>  70
000

<210>  71

<400>  71
000

<210>  72

<400>  72
000

<210>  73

<400>  73
000

<210>  74

<400>  74
000

<210>  75

<400>  75
000

<210>  76

<400>  76
000

<210>  77

<400>  77
000

<210>  78

<400>  78
000

<210>  79

<400>  79
000

<210>  80

<400>  80
000

<210>  81

<400>  81
000

<210>  82

<400>  82
000

<210>  83

<400>  83
000

<210>  84

<400>  84
000

<210>  85

<400>  85
000

<210>  86

<400>  86
000

<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90

<400>  90
000

<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100

<400>  100
000

<210>  101

<400>  101
000

<210>  102

<400>  102
000

<210>  103

<400>  103
000

<210>  104

<400>  104
000

<210>  105

<400>  105
000

<210>  106

<400>  106
000

<210>  107

<400>  107
000

<210>  108

<400>  108
000

<210>  109

<400>  109
000

<210>  110

<400>  110
000

<210>  111

<400>  111
000

<210>  112

<400>  112
000

<210>  113

<400>  113
000

<210>  114

<400>  114
000

<210>  115

<400>  115
000

<210>  116

<400>  116
000

<210>  117

<400>  117
000

<210>  118

<400>  118
000

<210>  119

<400>  119
000

<210>  120

<400>  120
000

<210>  121

<400>  121
000

<210>  122

<400>  122
000

<210>  123

<400>  123
000

<210>  124

<400>  124
000

<210>  125

<400>  125
000

<210>  126

<400>  126
000

<210>  127

<400>  127
000

<210>  128

<400>  128
000

<210>  129

<400>  129
000

<210>  130

<400>  130
000

<210>  131

<400>  131
000

<210>  132

<400>  132
000

<210>  133

<400>  133
000

<210>  134

<400>  134
000

<210>  135

<400>  135
000

<210>  136

<400>  136
000

<210>  137

<400>  137
000

<210>  138

<400>  138
000

<210>  139

<400>  139
000

<210>  140

<400>  140
000

<210>  141

<400>  141
000

<210>  142

<400>  142
000

<210>  143

<400>  143
000

<210>  144

<400>  144
000

<210>  145

<400>  145
000

<210>  146

<400>  146
000

<210>  147

<400>  147
000

<210>  148

<400>  148
000

<210>  149

<400>  149
000

<210>  150

<400>  150
000

<210>  151

<400>  151
000

<210>  152

<400>  152
000

<210>  153

<400>  153
000

<210>  154

<400>  154
000

<210>  155

<400>  155
000

<210>  156

<400>  156
000

<210>  157

<400>  157
000

<210>  158

<400>  158
000

<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161

<400>  161
000

<210>  162

<400>  162
000

<210>  163

<400>  163
000

<210>  164

<400>  164
000

<210>  165

<400>  165
000

<210>  166

<400>  166
000

<210>  167

<400>  167
000

<210>  168

<400>  168
000

<210>  169

<400>  169
000

<210>  170

<400>  170
000

<210>  171

<400>  171
000

<210>  172

<400>  172
000

<210>  173

<400>  173
000

<210>  174

<400>  174
000

<210>  175

<400>  175
000

<210>  176

<400>  176
000

<210>  177

<400>  177
000

<210>  178

<400>  178
000

<210>  179

<400>  179
000

<210>  180

<400>  180
000

<210>  181

<400>  181
000

<210>  182

<400>  182
000

<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187

<400>  187
000

<210>  188

<400>  188
000

<210>  189

<400>  189
000

<210>  190

<400>  190
000

<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194

<400>  194
000

<210>  195

<400>  195
000

<210>  196

<400>  196
000

<210>  197

<400>  197
000

<210>  198

<400>  198
000

<210>  199

<400>  199
000

<210>  200

<400>  200
000

<210>  201
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  201

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Cys 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  202
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  202

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Cys Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  203
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  203

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Cys Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  204
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  204

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Cys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  205
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  205

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Cys Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  206
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  206

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  207
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  207

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Cys Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  208
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  208

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  209
<211>  166
<212>  PRT
<213>  Helicobacter pylori

<400>  209

Leu Ser Lys Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
1               5                   10                  15      


Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr 
            20                  25                  30          


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
        35                  40                  45              


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
    50                  55                  60                  


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
65                  70                  75                  80  


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
                85                  90                  95      


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp 
            100                 105                 110         


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
        115                 120                 125             


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
    130                 135                 140                 


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
145                 150                 155                 160 


Ala Lys Ser Arg Lys Ser 
                165     


<210>  210
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  210
tgactgtgaa cgttcgagat ga                                                22


<210>  211
<211>  191
<212>  PRT
<213>  Trichoplusia ni

<400>  211

Thr Gln Cys Asn Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr 
1               5                   10                  15      


Met His Arg Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu 
            20                  25                  30          


Val Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys 
        35                  40                  45              


Asp Val Val Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala 
    50                  55                  60                  


Ser Glu Glu Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met 
65                  70                  75                  80  


Arg Gly Glu Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro 
                85                  90                  95      


Pro Thr Arg Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala 
            100                 105                 110         


Leu Ser Met Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys 
        115                 120                 125             


Ala Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr 
    130                 135                 140                 


Leu Thr Gly Asp Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu 
145                 150                 155                 160 


Ala Gly Lys Ala Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala 
                165                 170                 175     


Leu Gly Glu Phe Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
            180                 185                 190     


<210>  212
<211>  212
<212>  PRT
<213>  Trichoplusia ni

<400>  212

Ala Asp Thr Cys Tyr Asn Asp Val Ala Leu Asp Cys Gly Ile Thr Ser 
1               5                   10                  15      


Asn Ser Leu Ala Leu Pro Arg Cys Asn Ala Val Tyr Gly Glu Tyr Gly 
            20                  25                  30          


Ser His Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His 
        35                  40                  45              


Leu Glu Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn 
    50                  55                  60                  


Tyr Gln Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser 
65                  70                  75                  80  


Asp Glu Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys 
                85                  90                  95      


Arg Gly Asp Lys Met Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu 
            100                 105                 110         


Arg Lys Asn Tyr Thr Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys 
        115                 120                 125             


Ala Leu Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His 
    130                 135                 140                 


Arg Glu Ala Thr Arg Asn Ser Gln His Leu His Asp Pro Glu Ile Ala 
145                 150                 155                 160 


Gln Tyr Leu Glu Glu Glu Phe Ile Glu Asp His Ala Glu Lys Ile Arg 
                165                 170                 175     


Thr Leu Ala Gly His Thr Ser Asp Leu Lys Lys Phe Ile Thr Ala Asn 
            180                 185                 190         


Asn Gly His Asp Leu Ser Leu Ala Leu Tyr Val Phe Asp Glu Tyr Leu 
        195                 200                 205             


Gln Lys Thr Val 
    210         


<210>  213
<211>  174
<212>  PRT
<213>  Pyrococcus furiosus

<400>  213

Met Leu Ser Glu Arg Met Leu Lys Ala Leu Asn Asp Gln Leu Asn Arg 
1               5                   10                  15      


Glu Leu Tyr Ser Ala Tyr Leu Tyr Phe Ala Met Ala Ala Tyr Phe Glu 
            20                  25                  30          


Asp Leu Gly Leu Glu Gly Phe Ala Asn Trp Met Lys Ala Gln Ala Glu 
        35                  40                  45              


Glu Glu Ile Gly His Ala Leu Arg Phe Tyr Asn Tyr Ile Tyr Asp Arg 
    50                  55                  60                  


Asn Gly Arg Val Glu Leu Asp Glu Ile Pro Lys Pro Pro Lys Glu Trp 
65                  70                  75                  80  


Glu Ser Pro Leu Lys Ala Phe Glu Ala Ala Tyr Glu His Glu Lys Phe 
                85                  90                  95      


Ile Ser Lys Ser Ile Tyr Glu Leu Ala Ala Leu Ala Glu Glu Glu Lys 
            100                 105                 110         


Asp Tyr Ser Thr Arg Ala Phe Leu Glu Trp Phe Ile Asn Glu Gln Val 
        115                 120                 125             


Glu Glu Glu Ala Ser Val Lys Lys Ile Leu Asp Lys Leu Lys Phe Ala 
    130                 135                 140                 


Lys Asp Ser Pro Gln Ile Leu Phe Met Leu Asp Lys Glu Leu Ser Ala 
145                 150                 155                 160 


Arg Ala Pro Lys Leu Pro Gly Leu Leu Met Gln Gly Gly Glu 
                165                 170                 


<210>  214
<211>  183
<212>  PRT
<213>  Homo sapeins

<400>  214

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Gln 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Gln Glu Ser 
            180             


<210>  215
<211>  204
<212>  PRT
<213>  Homo sapeins

<400>  215

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Ser Ser 
            20                  25                  30          


Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser 
        35                  40                  45              


Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly 
    50                  55                  60                  


Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe 
65                  70                  75                  80  


Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu 
                85                  90                  95      


Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys 
            100                 105                 110         


Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala 
        115                 120                 125             


Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His 
    130                 135                 140                 


Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu 
145                 150                 155                 160 


Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp 
                165                 170                 175     


His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly 
            180                 185                 190         


Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp 
        195                 200                 


<210>  216
<211>  154
<212>  PRT
<213>  Aquifex aeolicus

<400>  216

Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly 
1               5                   10                  15      


Ile Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu 
            20                  25                  30          


Gly Ala Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile 
        35                  40                  45              


Thr Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly 
    50                  55                  60                  


Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val 
65                  70                  75                  80  


Leu Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val 
                85                  90                  95      


Ser Lys Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr 
            100                 105                 110         


Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala 
        115                 120                 125             


Gly Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile 
    130                 135                 140                 


Glu Met Ala Asn Leu Phe Lys Ser Leu Arg 
145                 150                 


<210>  217
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Bullfrog linker sequence

<400>  217

Glu Ser Gln Val Arg Gln Gln Phe 
1               5               


<210>  218
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  218

Cys Leu Val Pro Arg Gly Ser Leu Glu His His His His His His 
1               5                   10                  15  


<210>  219
<211>  156
<212>  PRT
<213>  Escherichia coli

<400>  219

Met Asn Ile Ile Glu Ala Asn Val Ala Thr Pro Asp Ala Arg Val Ala 
1               5                   10                  15      


Ile Thr Ile Ala Arg Phe Asn Asn Phe Ile Asn Asp Ser Leu Leu Glu 
            20                  25                  30          


Gly Ala Ile Asp Ala Leu Lys Arg Ile Gly Gln Val Lys Asp Glu Asn 
        35                  40                  45              


Ile Thr Val Val Trp Val Pro Gly Ala Tyr Glu Leu Pro Leu Ala Ala 
    50                  55                  60                  


Gly Ala Leu Ala Lys Thr Gly Lys Tyr Asp Ala Val Ile Ala Leu Gly 
65                  70                  75                  80  


Thr Val Ile Arg Gly Gly Thr Ala His Phe Glu Tyr Val Ala Gly Gly 
                85                  90                  95      


Ala Ser Asn Gly Leu Ala His Val Ala Gln Asp Ser Glu Ile Pro Val 
            100                 105                 110         


Ala Phe Gly Val Leu Thr Thr Glu Ser Ile Glu Gln Ala Ile Glu Arg 
        115                 120                 125             


Ala Gly Thr Lys Ala Gly Asn Lys Gly Ala Glu Ala Ala Leu Thr Ala 
    130                 135                 140                 


Leu Glu Met Ile Asn Val Leu Lys Ala Ile Lys Ala 
145                 150                 155     


<210>  220
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  220

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


<210>  221
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  221

Gly Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
            20                  25              


<210>  222
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  222

Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser 
1               5                   10                  15      


Asn Gly Ser Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser Ser Gly 
            20                  25                  30          


Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
        35                  40                  45      


<210>  223
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  223

Gly Gly Ser Gly Ser Ala Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Ala Gly Gly Ser Gly Gly Ser Gly 
            20                  25      


<210>  224
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  224

Gly Gly Ser Gly Ser Ala Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Glu Ala Ala Ala Lys Ala Ser Gly Gly Ser Gly Gly Ser Gly 
            20                  25                  30          


<210>  225
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  225

Ser Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly 
1               5                   10                  15      


Ser Ser Cys Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly 
            20                  25                  30          


Ala Ser Ser Gly Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Gly 
        35                  40                  45          


<210>  226
<211>  1086
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  226

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Leu Ala Tyr 
865                 870                 875                 880 


Phe Leu Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala 
                885                 890                 895     


Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro 
            900                 905                 910         


Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp 
        915                 920                 925             


Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe Gln 
    930                 935                 940                 


Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg 
945                 950                 955                 960 


Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys Lys 
                965                 970                 975     


Lys His Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr Pro 
            980                 985                 990         


Cys Thr Tyr Phe Tyr Gly Pro Thr  Pro Asp Ile Leu Pro  Val Val Thr 
        995                 1000                 1005             


Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp Val Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp Gly Gly  Thr Phe Lys 
    1025                 1030                 1035             


Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr Tyr Val  Ser Lys Phe 
    1040                 1045                 1050             


Ser Thr  Val Pro Val Ser His  His Glu Cys Ser Phe  Leu Lys Pro 
    1055                 1060                 1065             


Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser Gly Ser  His His His 
    1070                 1075                 1080             


His His  His 
    1085     


<210>  227
<211>  1339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  227

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Leu Ala Tyr 
865                 870                 875                 880 


Phe Leu Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala 
                885                 890                 895     


Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro 
            900                 905                 910         


Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp 
        915                 920                 925             


Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe Gln 
    930                 935                 940                 


Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg 
945                 950                 955                 960 


Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys Lys 
                965                 970                 975     


Lys His Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr Pro 
            980                 985                 990         


Cys Thr Tyr Phe Tyr Gly Pro Thr  Pro Asp Ile Leu Pro  Val Val Thr 
        995                 1000                 1005             


Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp Val Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp Gly Gly  Thr Phe Lys 
    1025                 1030                 1035             


Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr Tyr Val  Ser Lys Phe 
    1040                 1045                 1050             


Ser Thr  Val Pro Val Ser His  His Glu Cys Ser Phe  Leu Lys Pro 
    1055                 1060                 1065             


Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser Gly Gly  Ser Gly Ser 
    1070                 1075                 1080             


Ala Ser  Ser Gly Ala Ser Ala  Ser Gly Ser Ser Gly  Ser Gly Ser 
    1085                 1090                 1095             


Gly Ser  Gly Ser Ser Ser Ala  Ser Ser Gly Ala Ser  Ser Gly Gly 
    1100                 1105                 1110             


Ala Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Gly Ser  Gly Ser Ala 
    1115                 1120                 1125             


Ser Ser  Gly Ala Ser Ala Ser  Gly Ser Ser Gly Ser  Gly Ser Gly 
    1130                 1135                 1140             


Ser Gly  Ser Ser Ser Ala Ser  Ser Gly Ala Ser Ser  Gly Gly Ala 
    1145                 1150                 1155             


Ser Gly  Gly Ser Gly Gly Ser  Gly Glu Ser Gln Val  Arg Gln Gln 
    1160                 1165                 1170             


Phe Ser  Lys Asp Ile Glu Lys  Leu Leu Asn Glu Gln  Val Asn Lys 
    1175                 1180                 1185             


Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser Met Ser  Ser Trp Ser 
    1190                 1195                 1200             


Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His 
    1205                 1210                 1215             


Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu 
    1220                 1225                 1230             


Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro 
    1235                 1240                 1245             


Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr 
    1250                 1255                 1260             


Glu His  Glu Gln His Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp 
    1265                 1270                 1275             


His Ala  Ile Lys Cys Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln 
    1280                 1285                 1290             


Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu Val Leu  Phe Lys Asp 
    1295                 1300                 1305             


Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu 
    1310                 1315                 1320             


Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys 
    1325                 1330                 1335             


Ser 
    


<210>  228
<211>  1295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  228

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Leu Ala Tyr 
865                 870                 875                 880 


Phe Leu Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala 
                885                 890                 895     


Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro 
            900                 905                 910         


Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp 
        915                 920                 925             


Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe Gln 
    930                 935                 940                 


Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg 
945                 950                 955                 960 


Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys Lys 
                965                 970                 975     


Lys His Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr Pro 
            980                 985                 990         


Cys Thr Tyr Phe Tyr Gly Pro Thr  Pro Asp Ile Leu Pro  Val Val Thr 
        995                 1000                 1005             


Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp Val Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp Gly Gly  Thr Phe Lys 
    1025                 1030                 1035             


Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr Tyr Val  Ser Lys Phe 
    1040                 1045                 1050             


Ser Thr  Val Pro Val Ser His  His Glu Cys Ser Phe  Leu Lys Pro 
    1055                 1060                 1065             


Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser Gly Gly  Ser Gly Ser 
    1070                 1075                 1080             


Ala Ser  Ser Gly Ala Ser Ala  Ser Gly Ser Ser Gly  Ser Gly Ser 
    1085                 1090                 1095             


Gly Ser  Gly Ser Ser Ser Ala  Ser Ser Gly Ala Ser  Ser Gly Gly 
    1100                 1105                 1110             


Ala Ser  Gly Gly Ser Gly Gly  Ser Gly Glu Ser Gln  Val Arg Gln 
    1115                 1120                 1125             


Gln Phe  Ser Lys Asp Ile Glu  Lys Leu Leu Asn Glu  Gln Val Asn 
    1130                 1135                 1140             


Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met Ser Met  Ser Ser Trp 
    1145                 1150                 1155             


Ser Tyr  Thr His Ser Leu Asp  Gly Ala Gly Leu Phe  Leu Phe Asp 
    1160                 1165                 1170             


His Ala  Ala Glu Glu Tyr Glu  His Ala Lys Lys Leu  Ile Ile Phe 
    1175                 1180                 1185             


Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu Thr Ser  Ile Ser Ala 
    1190                 1195                 1200             


Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln Ile Phe  Gln Lys Ala 
    1205                 1210                 1215             


Tyr Glu  His Glu Gln His Ile  Ser Glu Ser Ile Asn  Asn Ile Val 
    1220                 1225                 1230             


Asp His  Ala Ile Lys Cys Lys  Asp His Ala Thr Phe  Asn Phe Leu 
    1235                 1240                 1245             


Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu Glu Val  Leu Phe Lys 
    1250                 1255                 1260             


Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly 
    1265                 1270                 1275             


Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg 
    1280                 1285                 1290             


Lys Ser  
    1295 


<210>  229
<211>  1263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  229

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Leu Ala Tyr 
865                 870                 875                 880 


Phe Leu Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala 
                885                 890                 895     


Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro 
            900                 905                 910         


Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp 
        915                 920                 925             


Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe Gln 
    930                 935                 940                 


Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg 
945                 950                 955                 960 


Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys Lys 
                965                 970                 975     


Lys His Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr Pro 
            980                 985                 990         


Cys Thr Tyr Phe Tyr Gly Pro Thr  Pro Asp Ile Leu Pro  Val Val Thr 
        995                 1000                 1005             


Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp Val Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp Gly Gly  Thr Phe Lys 
    1025                 1030                 1035             


Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr Tyr Val  Ser Lys Phe 
    1040                 1045                 1050             


Ser Thr  Val Pro Val Ser His  His Glu Cys Ser Phe  Leu Lys Pro 
    1055                 1060                 1065             


Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser Glu Pro  Glu Pro Glu 
    1070                 1075                 1080             


Pro Glu  Pro Glu Pro Gly Gly  Glu Ser Gln Val Arg  Gln Gln Phe 
    1085                 1090                 1095             


Ser Lys  Asp Ile Glu Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1100                 1105                 1110             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Ser Tyr 
    1115                 1120                 1125             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1130                 1135                 1140             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1145                 1150                 1155             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1160                 1165                 1170             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1175                 1180                 1185             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1190                 1195                 1200             


Ala Ile  Lys Cys Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1205                 1210                 1215             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1220                 1225                 1230             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1235                 1240                 1245             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1250                 1255                 1260             


<210>  230
<211>  1255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  230

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Leu Ala Tyr 
865                 870                 875                 880 


Phe Leu Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala 
                885                 890                 895     


Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro 
            900                 905                 910         


Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp 
        915                 920                 925             


Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe Gln 
    930                 935                 940                 


Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg 
945                 950                 955                 960 


Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys Lys 
                965                 970                 975     


Lys His Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr Pro 
            980                 985                 990         


Cys Thr Tyr Phe Tyr Gly Pro Thr  Pro Asp Ile Leu Pro  Val Val Thr 
        995                 1000                 1005             


Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp Val Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp Gly Gly  Thr Phe Lys 
    1025                 1030                 1035             


Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr Tyr Val  Ser Lys Phe 
    1040                 1045                 1050             


Ser Thr  Val Pro Val Ser His  His Glu Cys Ser Phe  Leu Lys Pro 
    1055                 1060                 1065             


Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser Gly Gly  Ser Gly Glu 
    1070                 1075                 1080             


Ser Gln  Val Arg Gln Gln Phe  Ser Lys Asp Ile Glu  Lys Leu Leu 
    1085                 1090                 1095             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1100                 1105                 1110             


Ser Met  Ser Ser Trp Ser Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1115                 1120                 1125             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1130                 1135                 1140             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1145                 1150                 1155             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1160                 1165                 1170             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1175                 1180                 1185             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Cys Lys  Asp His Ala 
    1190                 1195                 1200             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1205                 1210                 1215             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1220                 1225                 1230             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1235                 1240                 1245             


Ile Ala  Lys Ser Arg Lys Ser  
    1250                 1255 


<210>  231
<211>  1329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  231

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Asn Trp 
            20                  25                  30          


Ala Tyr Pro Cys Cys His Val Thr Gln Leu Arg Ala Gln His Leu Leu 
        35                  40                  45              


Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu Val Ser Asn Gln Thr Cys 
    50                  55                  60                  


Asp Ala Phe Ser Leu Ala Ser Leu Asn Ser Pro Lys Gln Gly Ser Asn 
65                  70                  75                  80  


Gln Leu Val Ile Ser Arg Cys Ala Asn Gly Leu Asn Val Val Ser Phe 
                85                  90                  95      


Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser Ala Leu Thr Gly His Leu 
            100                 105                 110         


Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu Tyr Gly Ser Phe Ser Val 
        115                 120                 125             


Glu Asp Leu Phe Gly Ala Gln Leu Asn Arg Tyr Ala Trp His Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Ala Ser Ser 
                165                 170                 175     


Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly Ala 
            180                 185                 190         


Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His Ala 
        195                 200                 205             


Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Leu Ala Lys Val Pro Gly 
    210                 215                 220                 


Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp Leu 
225                 230                 235                 240 


Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly Thr 
                245                 250                 255     


Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser Glu 
            260                 265                 270         


Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile Ser 
        275                 280                 285             


Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys Gln 
    290                 295                 300                 


Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His Ser 
305                 310                 315                 320 


Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu Ser 
                325                 330                 335     


Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys Phe 
            340                 345                 350         


Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His Val 
        355                 360                 365             


Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg Gly 
    370                 375                 380                 


Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Glu Tyr Ser 
385                 390                 395                 400 


Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn Tyr 
                405                 410                 415     


Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met Thr 
            420                 425                 430         


Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu Glu 
        435                 440                 445             


Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Glu Thr Glu Thr Leu Thr 
    450                 455                 460                 


Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala Val 
465                 470                 475                 480 


Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys Ser 
                485                 490                 495     


Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr Gly 
            500                 505                 510         


Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala Ala 
        515                 520                 525             


Ile Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr Thr 
    530                 535                 540                 


Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro Lys 
545                 550                 555                 560 


Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu Leu 
                565                 570                 575     


Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val Met 
            580                 585                 590         


Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu Arg 
        595                 600                 605             


Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu Leu 
    610                 615                 620                 


Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg Gly 
625                 630                 635                 640 


Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu Ser 
                645                 650                 655     


Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Ile Ala Pro Gln 
            660                 665                 670         


Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Gln Ala Val Asp Gly Phe 
        675                 680                 685             


Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His Leu 
    690                 695                 700                 


Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile Ile 
705                 710                 715                 720 


Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val Arg 
                725                 730                 735     


Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser Leu 
            740                 745                 750         


Phe Leu Ser Pro Val Ile Leu Asn Lys Cys Ser Gln Gly Ala Val Ala 
        755                 760                 765             


Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr Gln 
    770                 775                 780                 


Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu Lys 
785                 790                 795                 800 


Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln Asn 
                805                 810                 815     


Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val His 
            820                 825                 830         


Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly Leu 
        835                 840                 845             


Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly 
    850                 855                 860                 


Ala Ser Ala Ser Gly Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser 
865                 870                 875                 880 


Ser Ala Ser Ser Gly Ala Ile Thr Trp Val Pro Lys Pro Asn Val Glu 
                885                 890                 895     


Val Trp Pro Val Asp Pro Pro Pro Pro Val Asn Phe Asn Lys Thr Ala 
            900                 905                 910         


Glu Gln Glu Tyr Gly Asp Lys Glu Val Lys Leu Pro His Trp Thr Pro 
        915                 920                 925             


Thr Leu His Thr Phe Gln Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys 
    930                 935                 940                 


Thr Tyr Cys Asn Thr Arg Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys 
945                 950                 955                 960 


Phe Tyr Phe Thr Lys Lys Lys His Thr Trp Gln Gly Cys Phe Gln Ala 
                965                 970                 975     


Cys Ala Glu Leu Tyr Pro Cys Thr Tyr Phe Tyr Gly Pro Thr Pro Asp 
            980                 985                 990         


Ile Leu Pro Val Val Thr Arg Ser  Leu Gln Ala Ile Glu  Ser Leu Trp 
        995                 1000                 1005             


Val Gly  Val Tyr Arg Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp 
    1010                 1015                 1020             


Gly Gly  Thr Phe Lys Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr 
    1025                 1030                 1035             


Tyr Val  Ser Lys Phe Ser Thr  Val Pro Val Ser His  His Glu Cys 
    1040                 1045                 1050             


Ser Phe  Leu Lys Pro Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser 
    1055                 1060                 1065             


Gly Gly  Ser Gly Ser Ala Ser  Ser Gly Ala Ser Ala  Ser Gly Ser 
    1070                 1075                 1080             


Ser Gly  Ser Gly Ser Gly Ser  Gly Ser Ser Ser Ala  Ser Ser Gly 
    1085                 1090                 1095             


Ala Ser  Ser Gly Gly Ala Ser  Gly Gly Ser Gly Gly  Ser Gly Gly 
    1100                 1105                 1110             


Gly Ser  Gly Ser Ala Ser Ser  Gly Ala Ser Ala Ser  Gly Ser Ser 
    1115                 1120                 1125             


Gly Ser  Gly Ser Gly Ser Gly  Ser Ser Ser Ala Ser  Ser Gly Ala 
    1130                 1135                 1140             


Ser Ser  Gly Gly Ala Ser Gly  Gly Ser Gly Gly Ser  Gly Glu Ser 
    1145                 1150                 1155             


Gln Val  Arg Ser Gln Phe Ser  Lys Asp Ile Glu Lys  Leu Leu Asn 
    1160                 1165                 1170             


Glu Gln  Val Asn Lys Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser 
    1175                 1180                 1185             


Met Ser  Ser Trp Ser Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu 
    1190                 1195                 1200             


Phe Leu  Phe Asp His Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys 
    1205                 1210                 1215             


Leu Ile  Ile Phe Leu Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr 
    1220                 1225                 1230             


Ser Ile  Ser Ala Pro Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile 
    1235                 1240                 1245             


Phe Gln  Lys Ala Tyr Glu His  Glu Gln His Ile Ser  Glu Ser Ile 
    1250                 1255                 1260             


Asn Gln  Ile Val Asp His Ala  Ile Lys Cys Lys Asp  His Ala Thr 
    1265                 1270                 1275             


Phe Asn  Phe Leu Gln Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu 
    1280                 1285                 1290             


Val Leu  Phe Lys Asp Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Gln 
    1295                 1300                 1305             


Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile 
    1310                 1315                 1320             


Ala Lys  Ser Arg Lys Ser 
    1325                 


<210>  232
<211>  1066
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  232

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Glu 
        835                 840                 845             


Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu 
    850                 855                 860                 


Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu 
865                 870                 875                 880 


Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Ser Gln 
                885                 890                 895     


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
            900                 905                 910         


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
        915                 920                 925             


Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
    930                 935                 940                 


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
945                 950                 955                 960 


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
                965                 970                 975     


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
            980                 985                 990         


Glu Gln His Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
        995                 1000                 1005             


Lys Cys  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1010                 1015                 1020             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1025                 1030                 1035             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1040                 1045                 1050             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser 
    1055                 1060                 1065     


<210>  233
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  233

Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser 
1               5                   10                  15      


Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Ala Ser Ser Gly 
            20                  25                  30          


Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
        35                  40                  45      


<210>  234
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  234

Ser Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly 
1               5                   10                  15      


Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly 
            20                  25                  30          


<210>  235
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  235

Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser 
            20                  25                  30          


Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Ser Gly 
        35                  40                  45              


Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala 
65                  70                  75                  80  


Ser Gly Gly Ser Gly Gly Ser Gly 
                85              


<210>  236
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  236

Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser 
            20                  25                  30          


Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
        35                  40                  


<210>  237
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  237

Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Gly Gly 
1               5                   10          


<210>  238
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  238

Ser Gly Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
1               5                   10                  15      


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
            20                  25                  30          


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
        35                  40                  45              


<210>  239
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  239

Leu Ala Tyr Phe Leu Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala 
1               5                   10                  15      


Ala Ala Ala Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro 
            20                  25                  30          


Val Asp Pro Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu 
        35                  40                  45              


Tyr Gly Asp Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His 
    50                  55                  60                  


Thr Phe Gln Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys 
65                  70                  75                  80  


Asn Thr Arg Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe 
                85                  90                  95      


Thr Lys Lys Lys His Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu 
            100                 105                 110         


Leu Tyr Pro Cys Thr Tyr Phe Tyr Gly Pro Thr Pro Asp Ile Leu Pro 
        115                 120                 125             


Val Val Thr Arg Asn Leu Asn Ala Ile Glu Ser Leu Trp Val Gly Val 
    130                 135                 140                 


Tyr Arg Val Gly Glu Gly Asn Trp Thr Ser Leu Asp Gly Gly Thr Phe 
145                 150                 155                 160 


Lys Val Tyr Gln Ile Phe Gly Ser His Cys Thr Tyr Val Ser Lys Phe 
                165                 170                 175     


Ser Thr Val Pro Val Ser His His Glu Cys Ser Phe Leu Lys Pro Cys 
            180                 185                 190         


Leu Cys Val Ser Gln Arg Ser Asn Ser 
        195                 200     


<210>  240
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  240

Ala Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp 
1               5                   10                  15      


Pro Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly 
            20                  25                  30          


Asp Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe 
        35                  40                  45              


Gln Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr 
    50                  55                  60                  


Arg Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys 
65                  70                  75                  80  


Lys Lys His Thr Trp Gln Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr 
                85                  90                  95      


Pro Cys Thr Tyr Phe Tyr Gly Pro Thr Pro Asp Ile Leu Pro Val Val 
            100                 105                 110         


Thr Arg Ser Leu Gln Ala Ile Glu Ser Leu Trp Val Gly Val Tyr Arg 
        115                 120                 125             


Val Gly Glu Gly Asn Trp Thr Ser Leu Asp Gly Gly Thr Phe Lys Val 
    130                 135                 140                 


Tyr Gln Ile Phe Gly Ser His Cys Thr Tyr Val Ser Lys Phe Ser Thr 
145                 150                 155                 160 


Val Pro Val Ser His His Glu Cys Ser Phe Leu Lys Pro Cys Leu Cys 
                165                 170                 175     


Val Ser Gln Arg Ser Asn Ser 
            180             


<210>  241
<211>  1329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  241

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Asn Trp 
            20                  25                  30          


Ala Tyr Pro Cys Cys His Val Thr Gln Leu Arg Ala Gln His Leu Leu 
        35                  40                  45              


Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu Val Ser Asn Gln Thr Cys 
    50                  55                  60                  


Asp Ala Phe Ser Leu Ala Ser Leu Asn Ser Pro Lys Gln Gly Ser Asn 
65                  70                  75                  80  


Gln Leu Val Ile Ser Arg Cys Ala Asn Gly Leu Asn Val Val Ser Phe 
                85                  90                  95      


Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser Ala Leu Thr Gly His Leu 
            100                 105                 110         


Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu Tyr Gly Ser Phe Ser Val 
        115                 120                 125             


Glu Asp Leu Phe Gly Ala Gln Leu Asn Arg Tyr Ala Trp His Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Ala Ser Ser 
                165                 170                 175     


Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly Ala 
            180                 185                 190         


Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His Ala 
        195                 200                 205             


Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Leu Ala Lys Val Pro Gly 
    210                 215                 220                 


Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp Leu 
225                 230                 235                 240 


Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly Thr 
                245                 250                 255     


Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser Glu 
            260                 265                 270         


Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile Ser 
        275                 280                 285             


Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys Gln 
    290                 295                 300                 


Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His Ser 
305                 310                 315                 320 


Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu Ser 
                325                 330                 335     


Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys Phe 
            340                 345                 350         


Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His Val 
        355                 360                 365             


Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg Gly 
    370                 375                 380                 


Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Glu Tyr Ser 
385                 390                 395                 400 


Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn Tyr 
                405                 410                 415     


Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met Thr 
            420                 425                 430         


Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu Glu 
        435                 440                 445             


Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Glu Thr Glu Thr Leu Thr 
    450                 455                 460                 


Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala Val 
465                 470                 475                 480 


Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys Ser 
                485                 490                 495     


Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr Gly 
            500                 505                 510         


Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala Ala 
        515                 520                 525             


Ile Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr Thr 
    530                 535                 540                 


Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro Lys 
545                 550                 555                 560 


Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu Leu 
                565                 570                 575     


Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val Met 
            580                 585                 590         


Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu Arg 
        595                 600                 605             


Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu Leu 
    610                 615                 620                 


Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg Gly 
625                 630                 635                 640 


Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu Ser 
                645                 650                 655     


Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Ile Ala Pro Gln 
            660                 665                 670         


Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Gln Ala Val Asp Gly Phe 
        675                 680                 685             


Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His Leu 
    690                 695                 700                 


Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile Ile 
705                 710                 715                 720 


Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val Arg 
                725                 730                 735     


Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser Leu 
            740                 745                 750         


Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala Val Ala 
        755                 760                 765             


Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr Gln 
    770                 775                 780                 


Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu Lys 
785                 790                 795                 800 


Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln Asn 
                805                 810                 815     


Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val His 
            820                 825                 830         


Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly Leu 
        835                 840                 845             


Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly 
    850                 855                 860                 


Ala Ser Ala Ser Gly Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser 
865                 870                 875                 880 


Ser Ala Ser Ser Gly Ala Ile Thr Trp Val Pro Lys Pro Asn Val Glu 
                885                 890                 895     


Val Trp Pro Val Asp Pro Pro Pro Pro Val Asn Phe Asn Lys Thr Ala 
            900                 905                 910         


Glu Gln Glu Tyr Gly Asp Lys Glu Val Lys Leu Pro His Trp Thr Pro 
        915                 920                 925             


Thr Leu His Thr Phe Gln Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys 
    930                 935                 940                 


Thr Tyr Cys Asn Thr Arg Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys 
945                 950                 955                 960 


Phe Tyr Phe Thr Lys Lys Lys His Thr Trp Gln Gly Cys Phe Gln Ala 
                965                 970                 975     


Cys Ala Glu Leu Tyr Pro Cys Thr Tyr Phe Tyr Gly Pro Thr Pro Asp 
            980                 985                 990         


Ile Leu Pro Val Val Thr Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp 
        995                 1000                 1005             


Val Gly  Val Tyr Arg Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp 
    1010                 1015                 1020             


Gly Gly  Thr Phe Lys Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr 
    1025                 1030                 1035             


Tyr Val  Ser Lys Phe Ser Thr  Val Pro Val Ser His  His Glu Cys 
    1040                 1045                 1050             


Ser Phe  Leu Lys Pro Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser 
    1055                 1060                 1065             


Gly Gly  Ser Gly Ser Ala Ser  Ser Gly Ala Ser Ala  Ser Gly Ser 
    1070                 1075                 1080             


Ser Gly  Ser Gly Ser Gly Ser  Gly Ser Ser Ser Ala  Ser Ser Gly 
    1085                 1090                 1095             


Ala Ser  Ser Gly Gly Ala Ser  Gly Gly Ser Gly Gly  Ser Gly Gly 
    1100                 1105                 1110             


Gly Ser  Gly Ser Ala Ser Ser  Gly Ala Ser Ala Ser  Gly Ser Ser 
    1115                 1120                 1125             


Gly Ser  Gly Ser Gly Ser Gly  Ser Ser Ser Ala Ser  Ser Gly Ala 
    1130                 1135                 1140             


Ser Ser  Gly Gly Ala Ser Gly  Gly Ser Gly Gly Ser  Gly Glu Ser 
    1145                 1150                 1155             


Gln Val  Arg Ser Gln Phe Ser  Lys Asp Ile Glu Lys  Leu Leu Asn 
    1160                 1165                 1170             


Glu Gln  Val Asn Lys Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser 
    1175                 1180                 1185             


Met Ser  Ser Trp Ser Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu 
    1190                 1195                 1200             


Phe Leu  Phe Asp His Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys 
    1205                 1210                 1215             


Leu Ile  Ile Phe Leu Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr 
    1220                 1225                 1230             


Ser Ile  Ser Ala Pro Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile 
    1235                 1240                 1245             


Phe Gln  Lys Ala Tyr Glu His  Glu Gln His Ile Ser  Glu Ser Ile 
    1250                 1255                 1260             


Asn Gln  Ile Val Asp His Ala  Ile Lys Cys Lys Asp  His Ala Thr 
    1265                 1270                 1275             


Phe Asn  Phe Leu Gln Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu 
    1280                 1285                 1290             


Val Leu  Phe Lys Asp Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Gln 
    1295                 1300                 1305             


Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile 
    1310                 1315                 1320             


Ala Lys  Ser Arg Lys Ser 
    1325                 


<210>  242
<211>  1329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  242

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Asn Trp 
            20                  25                  30          


Ala Tyr Pro Cys Cys His Val Thr Gln Leu Arg Ala Gln His Leu Leu 
        35                  40                  45              


Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu Val Ser Asn Gln Thr Cys 
    50                  55                  60                  


Asp Ala Phe Ser Leu Ala Ser Leu Asn Ser Pro Lys Gln Gly Ser Asn 
65                  70                  75                  80  


Gln Leu Val Ile Ser Arg Cys Ala Asn Gly Leu Asn Val Val Ser Phe 
                85                  90                  95      


Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser Ala Leu Thr Gly His Leu 
            100                 105                 110         


Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu Tyr Gly Ser Phe Ser Val 
        115                 120                 125             


Glu Asp Leu Phe Gly Ala Gln Leu Asn Arg Tyr Ala Trp His Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Ala Ser Ser 
                165                 170                 175     


Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly Ala 
            180                 185                 190         


Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His Ala 
        195                 200                 205             


Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Leu Ala Lys Val Pro Gly 
    210                 215                 220                 


Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp Leu 
225                 230                 235                 240 


Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly Thr 
                245                 250                 255     


Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser Glu 
            260                 265                 270         


Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile Ser 
        275                 280                 285             


Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys Gln 
    290                 295                 300                 


Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His Ser 
305                 310                 315                 320 


Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu Ser 
                325                 330                 335     


Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys Phe 
            340                 345                 350         


Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His Val 
        355                 360                 365             


Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg Gly 
    370                 375                 380                 


Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Glu Tyr Ser 
385                 390                 395                 400 


Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn Tyr 
                405                 410                 415     


Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met Thr 
            420                 425                 430         


Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu Glu 
        435                 440                 445             


Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Glu Thr Glu Thr Leu Thr 
    450                 455                 460                 


Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala Val 
465                 470                 475                 480 


Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys Ser 
                485                 490                 495     


Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr Gly 
            500                 505                 510         


Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala Ala 
        515                 520                 525             


Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr Thr 
    530                 535                 540                 


Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro Lys 
545                 550                 555                 560 


Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu Leu 
                565                 570                 575     


Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val Met 
            580                 585                 590         


Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu Arg 
        595                 600                 605             


Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu Leu 
    610                 615                 620                 


Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg Gly 
625                 630                 635                 640 


Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu Ser 
                645                 650                 655     


Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala Pro Gln 
            660                 665                 670         


Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp Gly Phe 
        675                 680                 685             


Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His Leu 
    690                 695                 700                 


Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile Ile 
705                 710                 715                 720 


Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val Arg 
                725                 730                 735     


Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser Leu 
            740                 745                 750         


Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala Val Ala 
        755                 760                 765             


Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr Gln 
    770                 775                 780                 


Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu Lys 
785                 790                 795                 800 


Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln Asn 
                805                 810                 815     


Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val His 
            820                 825                 830         


Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly Leu 
        835                 840                 845             


Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly 
    850                 855                 860                 


Ala Ser Ala Ser Gly Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser 
865                 870                 875                 880 


Ser Ala Ser Ser Gly Ala Ile Thr Trp Val Pro Lys Pro Asn Val Glu 
                885                 890                 895     


Val Trp Pro Val Asp Pro Pro Pro Pro Val Asn Phe Asn Lys Thr Ala 
            900                 905                 910         


Glu Gln Glu Tyr Gly Asp Lys Glu Val Lys Leu Pro His Trp Thr Pro 
        915                 920                 925             


Thr Leu His Thr Phe Gln Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys 
    930                 935                 940                 


Thr Tyr Cys Asn Thr Arg Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys 
945                 950                 955                 960 


Phe Tyr Phe Thr Lys Lys Lys His Thr Trp Asn Gly Cys Phe Gln Ala 
                965                 970                 975     


Cys Ala Glu Leu Tyr Pro Cys Thr Tyr Phe Tyr Gly Pro Thr Pro Asp 
            980                 985                 990         


Ile Leu Pro Val Val Thr Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp 
        995                 1000                 1005             


Val Gly  Val Tyr Arg Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp 
    1010                 1015                 1020             


Gly Gly  Thr Phe Lys Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr 
    1025                 1030                 1035             


Tyr Val  Ser Lys Phe Ser Thr  Val Pro Val Ser His  His Glu Cys 
    1040                 1045                 1050             


Ser Phe  Leu Lys Pro Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser 
    1055                 1060                 1065             


Gly Gly  Ser Gly Ser Ala Ser  Ser Gly Ala Ser Ala  Ser Gly Ser 
    1070                 1075                 1080             


Ser Gly  Ser Gly Ser Gly Ser  Gly Ser Ser Ser Ala  Ser Ser Gly 
    1085                 1090                 1095             


Ala Ser  Ser Gly Gly Ala Ser  Gly Gly Ser Gly Gly  Ser Gly Gly 
    1100                 1105                 1110             


Gly Ser  Gly Ser Ala Ser Ser  Gly Ala Ser Ala Ser  Gly Ser Ser 
    1115                 1120                 1125             


Gly Ser  Gly Ser Gly Ser Gly  Ser Ser Ser Ala Ser  Ser Gly Ala 
    1130                 1135                 1140             


Ser Ser  Gly Gly Ala Ser Gly  Gly Ser Gly Gly Ser  Gly Glu Ser 
    1145                 1150                 1155             


Gln Val  Arg Ser Gln Phe Ser  Lys Asp Ile Glu Lys  Leu Leu Asn 
    1160                 1165                 1170             


Glu Gln  Val Asn Lys Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser 
    1175                 1180                 1185             


Met Ser  Ser Trp Ser Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu 
    1190                 1195                 1200             


Phe Leu  Phe Asp His Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys 
    1205                 1210                 1215             


Leu Ile  Ile Phe Leu Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr 
    1220                 1225                 1230             


Ser Ile  Ser Ala Pro Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile 
    1235                 1240                 1245             


Phe Gln  Lys Ala Tyr Glu His  Glu Gln His Ile Ser  Glu Ser Ile 
    1250                 1255                 1260             


Asn Gln  Ile Val Asp His Ala  Ile Lys Cys Lys Asp  His Ala Thr 
    1265                 1270                 1275             


Phe Asn  Phe Leu Gln Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu 
    1280                 1285                 1290             


Val Leu  Phe Lys Asp Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Gln 
    1295                 1300                 1305             


Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile 
    1310                 1315                 1320             


Ala Lys  Ser Arg Lys Ser 
    1325                 


<210>  243
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6xHis tag

<400>  243

His His His His His His 
1               5       


<210>  244
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  244

Gly Gly Gly Ser 
1               


<210>  245
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  245

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  246
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  246

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  247
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  247
tccatgacgt tcctgacgtt                                                   20


