                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  FERRITIN PROTEINS

<130>  01121-0035-00PCT

<150>  62/652,217
<151>  2018-04-03

<160>  537   

<170>  PatentIn version 3.5

<210>  1
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Thr Leu 
    130                 135                 140                 


Glu Gly Gln Leu Ser Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val 
                245                 250                 255     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            260                 265                 270         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        275                 280                 285             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    290                 295                 300                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
305                 310                 315                 320 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                325                 330                 335     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            340                 345                 350         


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
        355                 360                 365             


Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
    370                 375                 380                 


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
385                 390                 395                 400 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
                405                 410                 415     


Lys Gly Ile Ala Lys Ser Arg Lys Ser 
            420                 425 


<210>  2
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Asp Leu 
    130                 135                 140                 


Lys Gly Glu Leu Ser Ser Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val 
                245                 250                 255     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            260                 265                 270         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        275                 280                 285             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    290                 295                 300                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
305                 310                 315                 320 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                325                 330                 335     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            340                 345                 350         


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
        355                 360                 365             


Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
    370                 375                 380                 


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
385                 390                 395                 400 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
                405                 410                 415     


Lys Gly Ile Ala Lys Ser Arg Lys Ser 
            420                 425 


<210>  3
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Thr Leu 
    130                 135                 140                 


Glu Gly Lys Val Ala Asn Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val 
                245                 250                 255     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            260                 265                 270         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        275                 280                 285             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    290                 295                 300                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
305                 310                 315                 320 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                325                 330                 335     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            340                 345                 350         


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
        355                 360                 365             


Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
    370                 375                 380                 


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
385                 390                 395                 400 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
                405                 410                 415     


Lys Gly Ile Ala Lys Ser Arg Lys Ser 
            420                 425 


<210>  4
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val 
                245                 250                 255     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            260                 265                 270         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        275                 280                 285             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    290                 295                 300                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
305                 310                 315                 320 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                325                 330                 335     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            340                 345                 350         


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
        355                 360                 365             


Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
    370                 375                 380                 


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
385                 390                 395                 400 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
                405                 410                 415     


Lys Gly Ile Ala Lys Ser Arg Lys Ser 
            420                 425 


<210>  5
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Asp Glu Lys Asn Ser Ala Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Lys 
            20                  25                  30          


Ala Thr Val Asp Lys Ile Glu Leu Lys Gly Thr Ser Asp Lys Asp Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Thr Lys Asp Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ala Asp Asp Leu Ser Lys Thr Thr Phe Glu Leu Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Arg Lys Val Ser Ser Lys Asp Lys 
                85                  90                  95      


Thr Ser Thr Asp Glu Met Phe Asn Glu Lys Gly Glu Leu Ser Ala Lys 
            100                 105                 110         


Thr Met Thr Arg Glu Asn Gly Thr Lys Leu Glu Tyr Thr Glu Met Lys 
        115                 120                 125             


Ser Asp Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asn Phe Thr Leu 
    130                 135                 140                 


Glu Gly Lys Val Ala Asn Asp Lys Val Thr Leu Glu Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Glu Ile Ala Lys Ser Gly Glu Val Thr Val 
                165                 170                 175     


Ala Leu Asn Asp Thr Asn Thr Thr Gln Ala Thr Lys Lys Thr Gly Ala 
            180                 185                 190         


Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Thr Gln Leu Val Phe Thr Lys Gln Asp Thr Ile Thr Val Gln Lys 
    210                 215                 220                 


Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Thr Ala Val Glu Ile Lys 
225                 230                 235                 240 


Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val 
                245                 250                 255     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            260                 265                 270         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        275                 280                 285             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    290                 295                 300                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
305                 310                 315                 320 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                325                 330                 335     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            340                 345                 350         


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
        355                 360                 365             


Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
    370                 375                 380                 


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
385                 390                 395                 400 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
                405                 410                 415     


Lys Gly Ile Ala Lys Ser Arg Lys Ser 
            420                 425 


<210>  6
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Glu Lys Ala Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ser Gln Asp Leu Asn Gln Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Arg Lys Val Asn Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys 
            100                 105                 110         


Val Val Thr Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys 
        115                 120                 125             


Asn Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Asp Gly Gly Glu Thr Lys Leu Thr Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Ala Leu Asn Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Thr Gly 
            180                 185                 190         


Glu Trp Lys Ser Asp Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln 
        195                 200                 205             


Lys Pro Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln 
    210                 215                 220                 


Asn Tyr Asn Arg Ala Gly Asn Ala Leu Glu Gly Ser Pro Ala Glu Ile 
225                 230                 235                 240 


Lys Asp Leu Ala Glu Leu Lys Ala Ala Leu Lys Gly Ser Glu Ser Gln 
                245                 250                 255     


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
            260                 265                 270         


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
        275                 280                 285             


Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
    290                 295                 300                 


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
305                 310                 315                 320 


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
                325                 330                 335     


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
            340                 345                 350         


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
        355                 360                 365             


Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
    370                 375                 380                 


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
385                 390                 395                 400 


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
                405                 410                 415     


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
            420                 425     


<210>  7
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Ser Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ser Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Asn Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Ile Glu Glu Lys Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys 
            100                 105                 110         


Thr Ile Leu Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys 
        115                 120                 125             


Ser Asp Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Lys Thr Thr Leu Lys Val Thr Glu Gly 
145                 150                 155                 160 


Thr Val Val Leu Ser Lys His Ile Pro Asn Ser Gly Glu Ile Thr Val 
                165                 170                 175     


Glu Leu Asn Asp Ser Asn Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys 
            180                 185                 190         


Trp Asp Ser Asn Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asn Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys 
    210                 215                 220                 


Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Asn Ala Val Glu Ile Lys 
225                 230                 235                 240 


Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val 
                245                 250                 255     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            260                 265                 270         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        275                 280                 285             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    290                 295                 300                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
305                 310                 315                 320 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                325                 330                 335     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            340                 345                 350         


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
        355                 360                 365             


Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
    370                 375                 380                 


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
385                 390                 395                 400 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
                405                 410                 415     


Lys Gly Ile Ala Lys Ser Arg Lys Ser 
            420                 425 


<210>  8
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ala Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Ile Ser Glu Lys 
            100                 105                 110         


Thr Ile Val Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Ala Leu Asp Asp Ser Asp Thr Thr Gln Ala Thr Lys Lys Thr Gly 
            180                 185                 190         


Lys Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln 
    210                 215                 220                 


Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile 
225                 230                 235                 240 


Thr Thr Leu Glu Lys Leu Lys Asp Ala Leu Lys Gly Ser Glu Ser Gln 
                245                 250                 255     


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
            260                 265                 270         


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
        275                 280                 285             


Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
    290                 295                 300                 


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
305                 310                 315                 320 


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
                325                 330                 335     


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
            340                 345                 350         


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
        355                 360                 365             


Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
    370                 375                 380                 


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
385                 390                 395                 400 


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
                405                 410                 415     


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
            420                 425     


<210>  9
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Thr 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Ser Thr Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Gly Lys Gly Glu Thr Ser Glu Lys 
            100                 105                 110         


Thr Ile Val Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Ala Ala Leu Asp Asp Ser Asp Thr Thr Arg Ala Thr Lys Lys Thr Gly 
            180                 185                 190         


Lys Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln 
    210                 215                 220                 


Arg Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile 
225                 230                 235                 240 


Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln 
                245                 250                 255     


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
            260                 265                 270         


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
        275                 280                 285             


Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
    290                 295                 300                 


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
305                 310                 315                 320 


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
                325                 330                 335     


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
            340                 345                 350         


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
        355                 360                 365             


Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
    370                 375                 380                 


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
385                 390                 395                 400 


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
                405                 410                 415     


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
            420                 425     


<210>  10
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Ala Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys 
            100                 105                 110         


Val Val Thr Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Gln 
        115                 120                 125             


Asn Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Ser Leu Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Ala Asp Gly Glu Thr Lys Leu Thr Val Glu Ala 
145                 150                 155                 160 


Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Glu Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Glu Leu Lys Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Ser Gly 
            180                 185                 190         


Thr Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln 
    210                 215                 220                 


Lys Tyr Asn Thr Ala Gly Thr Lys Leu Glu Gly Ser Pro Ala Glu Ile 
225                 230                 235                 240 


Lys Asp Leu Glu Ala Leu Lys Ala Ala Leu Lys Gly Ser Glu Ser Gln 
                245                 250                 255     


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
            260                 265                 270         


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
        275                 280                 285             


Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
    290                 295                 300                 


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
305                 310                 315                 320 


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
                325                 330                 335     


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
            340                 345                 350         


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
        355                 360                 365             


Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
    370                 375                 380                 


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
385                 390                 395                 400 


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
                405                 410                 415     


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
            420                 425     


<210>  11
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Ser Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ser Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Asn Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Ile Glu Glu Lys Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys 
            100                 105                 110         


Thr Ile Leu Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys 
        115                 120                 125             


Ser Asp Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Lys Thr Thr Leu Lys Val Thr Glu Gly 
145                 150                 155                 160 


Thr Val Val Leu Ser Lys His Ile Pro Asn Ser Gly Glu Ile Thr Val 
                165                 170                 175     


Glu Leu Asn Asp Ser Asn Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys 
            180                 185                 190         


Trp Asp Ser Asn Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asn Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys 
    210                 215                 220                 


Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Asn Ala Val Glu Ile Lys 
225                 230                 235                 240 


Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys Cys Leu Val Pro Arg Gly 
                245                 250                 255     


Ser Leu Glu His His His His His His 
            260                 265 


<210>  12
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Thr Leu 
    130                 135                 140                 


Glu Gly Gln Leu Ser Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Gly Gly Ser Met Gln 
                245                 250                 255     


Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly Ile Val 
            260                 265                 270         


Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu Gly Ala 
        275                 280                 285             


Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile Thr Leu 
    290                 295                 300                 


Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly Glu Leu 
305                 310                 315                 320 


Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val Leu Ile 
                325                 330                 335     


Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val Ser Lys 
            340                 345                 350         


Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr Phe Gly 
        355                 360                 365             


Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala Gly Thr 
    370                 375                 380                 


Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile Glu Met 
385                 390                 395                 400 


Ala Asn Leu Phe Lys Ser Leu Arg 
                405             


<210>  13
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Asp Leu 
    130                 135                 140                 


Lys Gly Glu Leu Ser Ser Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Gly Gly Ser Met Gln 
                245                 250                 255     


Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly Ile Val 
            260                 265                 270         


Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu Gly Ala 
        275                 280                 285             


Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile Thr Leu 
    290                 295                 300                 


Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly Glu Leu 
305                 310                 315                 320 


Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val Leu Ile 
                325                 330                 335     


Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val Ser Lys 
            340                 345                 350         


Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr Phe Gly 
        355                 360                 365             


Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala Gly Thr 
    370                 375                 380                 


Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile Glu Met 
385                 390                 395                 400 


Ala Asn Leu Phe Lys Ser Leu Arg 
                405             


<210>  14
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Thr Leu 
    130                 135                 140                 


Glu Gly Lys Val Ala Asn Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Gly Gly Ser Met Gln 
                245                 250                 255     


Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly Ile Val 
            260                 265                 270         


Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu Gly Ala 
        275                 280                 285             


Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile Thr Leu 
    290                 295                 300                 


Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly Glu Leu 
305                 310                 315                 320 


Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val Leu Ile 
                325                 330                 335     


Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val Ser Lys 
            340                 345                 350         


Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr Phe Gly 
        355                 360                 365             


Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala Gly Thr 
    370                 375                 380                 


Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile Glu Met 
385                 390                 395                 400 


Ala Asn Leu Phe Lys Ser Leu Arg 
                405             


<210>  15
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Gly Gly Ser Met Gln 
                245                 250                 255     


Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly Ile Val 
            260                 265                 270         


Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu Gly Ala 
        275                 280                 285             


Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile Thr Leu 
    290                 295                 300                 


Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly Glu Leu 
305                 310                 315                 320 


Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val Leu Ile 
                325                 330                 335     


Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val Ser Lys 
            340                 345                 350         


Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr Phe Gly 
        355                 360                 365             


Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala Gly Thr 
    370                 375                 380                 


Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile Glu Met 
385                 390                 395                 400 


Ala Asn Leu Phe Lys Ser Leu Arg 
                405             


<210>  16
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Met Asp Glu Lys Asn Ser Ala Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Lys 
            20                  25                  30          


Ala Thr Val Asp Lys Ile Glu Leu Lys Gly Thr Ser Asp Lys Asp Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Thr Lys Asp Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ala Asp Asp Leu Ser Lys Thr Thr Phe Glu Leu Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Arg Lys Val Ser Ser Lys Asp Lys 
                85                  90                  95      


Thr Ser Thr Asp Glu Met Phe Asn Glu Lys Gly Glu Leu Ser Ala Lys 
            100                 105                 110         


Thr Met Thr Arg Glu Asn Gly Thr Lys Leu Glu Tyr Thr Glu Met Lys 
        115                 120                 125             


Ser Asp Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asn Phe Thr Leu 
    130                 135                 140                 


Glu Gly Lys Val Ala Asn Asp Lys Val Thr Leu Glu Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Glu Ile Ala Lys Ser Gly Glu Val Thr Val 
                165                 170                 175     


Ala Leu Asn Asp Thr Asn Thr Thr Gln Ala Thr Lys Lys Thr Gly Ala 
            180                 185                 190         


Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Thr Gln Leu Val Phe Thr Lys Gln Asp Thr Ile Thr Val Gln Lys 
    210                 215                 220                 


Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Thr Ala Val Glu Ile Lys 
225                 230                 235                 240 


Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys Gly Gly Gly Ser Met Gln 
                245                 250                 255     


Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly Ile Val 
            260                 265                 270         


Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu Gly Ala 
        275                 280                 285             


Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile Thr Leu 
    290                 295                 300                 


Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly Glu Leu 
305                 310                 315                 320 


Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val Leu Ile 
                325                 330                 335     


Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val Ser Lys 
            340                 345                 350         


Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr Phe Gly 
        355                 360                 365             


Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala Gly Thr 
    370                 375                 380                 


Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile Glu Met 
385                 390                 395                 400 


Ala Asn Leu Phe Lys Ser Leu Arg 
                405             


<210>  17
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Glu Lys Ala Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ser Gln Asp Leu Asn Gln Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Arg Lys Val Asn Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys 
            100                 105                 110         


Val Val Thr Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys 
        115                 120                 125             


Asn Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Asp Gly Gly Glu Thr Lys Leu Thr Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Ala Leu Asn Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Thr Gly 
            180                 185                 190         


Glu Trp Lys Ser Asp Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln 
        195                 200                 205             


Lys Pro Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln 
    210                 215                 220                 


Asn Tyr Asn Arg Ala Gly Asn Ala Leu Glu Gly Ser Pro Ala Glu Ile 
225                 230                 235                 240 


Lys Asp Leu Ala Glu Leu Lys Ala Ala Leu Lys Gly Gly Gly Ser Met 
                245                 250                 255     


Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly Ile 
            260                 265                 270         


Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu Gly 
        275                 280                 285             


Ala Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile Thr 
    290                 295                 300                 


Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly Glu 
305                 310                 315                 320 


Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val Leu 
                325                 330                 335     


Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val Ser 
            340                 345                 350         


Lys Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr Phe 
        355                 360                 365             


Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala Gly 
    370                 375                 380                 


Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile Glu 
385                 390                 395                 400 


Met Ala Asn Leu Phe Lys Ser Leu Arg 
                405                 


<210>  18
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Ser Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ser Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Asn Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Ile Glu Glu Lys Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys 
            100                 105                 110         


Thr Ile Leu Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys 
        115                 120                 125             


Ser Asp Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Lys Thr Thr Leu Lys Val Thr Glu Gly 
145                 150                 155                 160 


Thr Val Val Leu Ser Lys His Ile Pro Asn Ser Gly Glu Ile Thr Val 
                165                 170                 175     


Glu Leu Asn Asp Ser Asn Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys 
            180                 185                 190         


Trp Asp Ser Asn Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asn Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys 
    210                 215                 220                 


Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Asn Ala Val Glu Ile Lys 
225                 230                 235                 240 


Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys Gly Gly Gly Ser Met Gln 
                245                 250                 255     


Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly Ile Val 
            260                 265                 270         


Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu Gly Ala 
        275                 280                 285             


Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile Thr Leu 
    290                 295                 300                 


Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly Glu Leu 
305                 310                 315                 320 


Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val Leu Ile 
                325                 330                 335     


Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val Ser Lys 
            340                 345                 350         


Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr Phe Gly 
        355                 360                 365             


Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala Gly Thr 
    370                 375                 380                 


Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile Glu Met 
385                 390                 395                 400 


Ala Asn Leu Phe Lys Ser Leu Arg 
                405             


<210>  19
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ala Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Ile Ser Glu Lys 
            100                 105                 110         


Thr Ile Val Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Ala Leu Asp Asp Ser Asp Thr Thr Gln Ala Thr Lys Lys Thr Gly 
            180                 185                 190         


Lys Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln 
    210                 215                 220                 


Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile 
225                 230                 235                 240 


Thr Thr Leu Glu Lys Leu Lys Asp Ala Leu Lys Gly Gly Gly Ser Met 
                245                 250                 255     


Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly Ile 
            260                 265                 270         


Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu Gly 
        275                 280                 285             


Ala Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile Thr 
    290                 295                 300                 


Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly Glu 
305                 310                 315                 320 


Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val Leu 
                325                 330                 335     


Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val Ser 
            340                 345                 350         


Lys Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr Phe 
        355                 360                 365             


Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala Gly 
    370                 375                 380                 


Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile Glu 
385                 390                 395                 400 


Met Ala Asn Leu Phe Lys Ser Leu Arg 
                405                 


<210>  20
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Thr 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Ser Thr Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Gly Lys Gly Glu Thr Ser Glu Lys 
            100                 105                 110         


Thr Ile Val Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Ala Ala Leu Asp Asp Ser Asp Thr Thr Arg Ala Thr Lys Lys Thr Gly 
            180                 185                 190         


Lys Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln 
    210                 215                 220                 


Arg Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile 
225                 230                 235                 240 


Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu Lys Gly Gly Gly Ser Met 
                245                 250                 255     


Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly Ile 
            260                 265                 270         


Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu Gly 
        275                 280                 285             


Ala Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile Thr 
    290                 295                 300                 


Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly Glu 
305                 310                 315                 320 


Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val Leu 
                325                 330                 335     


Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val Ser 
            340                 345                 350         


Lys Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr Phe 
        355                 360                 365             


Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala Gly 
    370                 375                 380                 


Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile Glu 
385                 390                 395                 400 


Met Ala Asn Leu Phe Lys Ser Leu Arg 
                405                 


<210>  21
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Ala Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys 
            100                 105                 110         


Val Val Thr Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Gln 
        115                 120                 125             


Asn Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Ser Leu Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Ala Asp Gly Glu Thr Lys Leu Thr Val Glu Ala 
145                 150                 155                 160 


Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Glu Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Glu Leu Lys Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Ser Gly 
            180                 185                 190         


Thr Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln 
    210                 215                 220                 


Lys Tyr Asn Thr Ala Gly Thr Lys Leu Glu Gly Ser Pro Ala Glu Ile 
225                 230                 235                 240 


Lys Asp Leu Glu Ala Leu Lys Ala Ala Leu Lys Gly Gly Gly Ser Met 
                245                 250                 255     


Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly Ile 
            260                 265                 270         


Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu Gly 
        275                 280                 285             


Ala Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile Thr 
    290                 295                 300                 


Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly Glu 
305                 310                 315                 320 


Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val Leu 
                325                 330                 335     


Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val Ser 
            340                 345                 350         


Lys Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr Phe 
        355                 360                 365             


Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala Gly 
    370                 375                 380                 


Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile Glu 
385                 390                 395                 400 


Met Ala Asn Leu Phe Lys Ser Leu Arg 
                405                 


<210>  22
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Thr Leu 
    130                 135                 140                 


Glu Gly Gln Leu Ser Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Met Thr Thr Ala 
                245                 250                 255     


Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser Glu Ala Ala 
            260                 265                 270         


Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
        275                 280                 285             


Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
    290                 295                 300                 


Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
305                 310                 315                 320 


Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
                325                 330                 335     


Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn Ala 
            340                 345                 350         


Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu 
        355                 360                 365             


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
    370                 375                 380                 


Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys Glu 
385                 390                 395                 400 


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser 
                405                 410                 415     


Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp 
            420                 425                 430         


Asn Glu Ser 
        435 


<210>  23
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Asp Leu 
    130                 135                 140                 


Lys Gly Glu Leu Ser Ser Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Met Thr Thr Ala 
                245                 250                 255     


Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser Glu Ala Ala 
            260                 265                 270         


Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
        275                 280                 285             


Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
    290                 295                 300                 


Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
305                 310                 315                 320 


Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
                325                 330                 335     


Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn Ala 
            340                 345                 350         


Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu 
        355                 360                 365             


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
    370                 375                 380                 


Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys Glu 
385                 390                 395                 400 


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser 
                405                 410                 415     


Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp 
            420                 425                 430         


Asn Glu Ser 
        435 


<210>  24
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Thr Leu 
    130                 135                 140                 


Glu Gly Lys Val Ala Asn Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Met Thr Thr Ala 
                245                 250                 255     


Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser Glu Ala Ala 
            260                 265                 270         


Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
        275                 280                 285             


Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
    290                 295                 300                 


Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
305                 310                 315                 320 


Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
                325                 330                 335     


Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn Ala 
            340                 345                 350         


Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu 
        355                 360                 365             


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
    370                 375                 380                 


Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys Glu 
385                 390                 395                 400 


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser 
                405                 410                 415     


Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp 
            420                 425                 430         


Asn Glu Ser 
        435 


<210>  25
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Met Thr Thr Ala 
                245                 250                 255     


Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser Glu Ala Ala 
            260                 265                 270         


Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
        275                 280                 285             


Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
    290                 295                 300                 


Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
305                 310                 315                 320 


Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
                325                 330                 335     


Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn Ala 
            340                 345                 350         


Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu 
        355                 360                 365             


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
    370                 375                 380                 


Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys Glu 
385                 390                 395                 400 


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser 
                405                 410                 415     


Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp 
            420                 425                 430         


Asn Glu Ser 
        435 


<210>  26
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Met Asp Glu Lys Asn Ser Ala Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Lys 
            20                  25                  30          


Ala Thr Val Asp Lys Ile Glu Leu Lys Gly Thr Ser Asp Lys Asp Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Thr Lys Asp Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ala Asp Asp Leu Ser Lys Thr Thr Phe Glu Leu Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Arg Lys Val Ser Ser Lys Asp Lys 
                85                  90                  95      


Thr Ser Thr Asp Glu Met Phe Asn Glu Lys Gly Glu Leu Ser Ala Lys 
            100                 105                 110         


Thr Met Thr Arg Glu Asn Gly Thr Lys Leu Glu Tyr Thr Glu Met Lys 
        115                 120                 125             


Ser Asp Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asn Phe Thr Leu 
    130                 135                 140                 


Glu Gly Lys Val Ala Asn Asp Lys Val Thr Leu Glu Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Glu Ile Ala Lys Ser Gly Glu Val Thr Val 
                165                 170                 175     


Ala Leu Asn Asp Thr Asn Thr Thr Gln Ala Thr Lys Lys Thr Gly Ala 
            180                 185                 190         


Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Thr Gln Leu Val Phe Thr Lys Gln Asp Thr Ile Thr Val Gln Lys 
    210                 215                 220                 


Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Thr Ala Val Glu Ile Lys 
225                 230                 235                 240 


Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys Gly Ser Met Thr Thr Ala 
                245                 250                 255     


Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser Glu Ala Ala 
            260                 265                 270         


Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
        275                 280                 285             


Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
    290                 295                 300                 


Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
305                 310                 315                 320 


Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
                325                 330                 335     


Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn Ala 
            340                 345                 350         


Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu 
        355                 360                 365             


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
    370                 375                 380                 


Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys Glu 
385                 390                 395                 400 


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser 
                405                 410                 415     


Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp 
            420                 425                 430         


Asn Glu Ser 
        435 


<210>  27
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Glu Lys Ala Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ser Gln Asp Leu Asn Gln Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Arg Lys Val Asn Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys 
            100                 105                 110         


Val Val Thr Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys 
        115                 120                 125             


Asn Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Asp Gly Gly Glu Thr Lys Leu Thr Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Ala Leu Asn Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Thr Gly 
            180                 185                 190         


Glu Trp Lys Ser Asp Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln 
        195                 200                 205             


Lys Pro Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln 
    210                 215                 220                 


Asn Tyr Asn Arg Ala Gly Asn Ala Leu Glu Gly Ser Pro Ala Glu Ile 
225                 230                 235                 240 


Lys Asp Leu Ala Glu Leu Lys Ala Ala Leu Lys Gly Ser Met Thr Thr 
                245                 250                 255     


Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser Glu Ala 
            260                 265                 270         


Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr 
        275                 280                 285             


Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn 
    290                 295                 300                 


Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala 
305                 310                 315                 320 


Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu 
                325                 330                 335     


Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn 
            340                 345                 350         


Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu 
        355                 360                 365             


Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys 
    370                 375                 380                 


Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys 
385                 390                 395                 400 


Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu 
                405                 410                 415     


Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser 
            420                 425                 430         


Asp Asn Glu Ser 
        435     


<210>  28
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Ser Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ser Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Asn Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Ile Glu Glu Lys Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys 
            100                 105                 110         


Thr Ile Leu Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys 
        115                 120                 125             


Ser Asp Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Lys Thr Thr Leu Lys Val Thr Glu Gly 
145                 150                 155                 160 


Thr Val Val Leu Ser Lys His Ile Pro Asn Ser Gly Glu Ile Thr Val 
                165                 170                 175     


Glu Leu Asn Asp Ser Asn Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys 
            180                 185                 190         


Trp Asp Ser Asn Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asn Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys 
    210                 215                 220                 


Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Asn Ala Val Glu Ile Lys 
225                 230                 235                 240 


Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys Gly Ser Met Thr Thr Ala 
                245                 250                 255     


Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser Glu Ala Ala 
            260                 265                 270         


Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
        275                 280                 285             


Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
    290                 295                 300                 


Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
305                 310                 315                 320 


Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
                325                 330                 335     


Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn Ala 
            340                 345                 350         


Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu 
        355                 360                 365             


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
    370                 375                 380                 


Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys Glu 
385                 390                 395                 400 


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser 
                405                 410                 415     


Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp 
            420                 425                 430         


Asn Glu Ser 
        435 


<210>  29
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ala Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Ile Ser Glu Lys 
            100                 105                 110         


Thr Ile Val Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Ala Leu Asp Asp Ser Asp Thr Thr Gln Ala Thr Lys Lys Thr Gly 
            180                 185                 190         


Lys Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln 
    210                 215                 220                 


Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile 
225                 230                 235                 240 


Thr Thr Leu Glu Lys Leu Lys Asp Ala Leu Lys Gly Ser Met Thr Thr 
                245                 250                 255     


Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser Glu Ala 
            260                 265                 270         


Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr 
        275                 280                 285             


Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn 
    290                 295                 300                 


Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala 
305                 310                 315                 320 


Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu 
                325                 330                 335     


Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn 
            340                 345                 350         


Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu 
        355                 360                 365             


Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys 
    370                 375                 380                 


Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys 
385                 390                 395                 400 


Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu 
                405                 410                 415     


Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser 
            420                 425                 430         


Asp Asn Glu Ser 
        435     


<210>  30
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Thr 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Ser Thr Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Gly Lys Gly Glu Thr Ser Glu Lys 
            100                 105                 110         


Thr Ile Val Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Ala Ala Leu Asp Asp Ser Asp Thr Thr Arg Ala Thr Lys Lys Thr Gly 
            180                 185                 190         


Lys Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln 
    210                 215                 220                 


Arg Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile 
225                 230                 235                 240 


Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu Lys Gly Ser Met Thr Thr 
                245                 250                 255     


Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser Glu Ala 
            260                 265                 270         


Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr 
        275                 280                 285             


Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn 
    290                 295                 300                 


Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala 
305                 310                 315                 320 


Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu 
                325                 330                 335     


Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn 
            340                 345                 350         


Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu 
        355                 360                 365             


Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys 
    370                 375                 380                 


Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys 
385                 390                 395                 400 


Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu 
                405                 410                 415     


Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser 
            420                 425                 430         


Asp Asn Glu Ser 
        435     


<210>  31
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Ala Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys 
            100                 105                 110         


Val Val Thr Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Gln 
        115                 120                 125             


Asn Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Ser Leu Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Ala Asp Gly Glu Thr Lys Leu Thr Val Glu Ala 
145                 150                 155                 160 


Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Glu Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Glu Leu Lys Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Ser Gly 
            180                 185                 190         


Thr Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln 
    210                 215                 220                 


Lys Tyr Asn Thr Ala Gly Thr Lys Leu Glu Gly Ser Pro Ala Glu Ile 
225                 230                 235                 240 


Lys Asp Leu Glu Ala Leu Lys Ala Ala Leu Lys Gly Ser Met Thr Thr 
                245                 250                 255     


Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser Glu Ala 
            260                 265                 270         


Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr 
        275                 280                 285             


Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn 
    290                 295                 300                 


Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala 
305                 310                 315                 320 


Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu 
                325                 330                 335     


Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn 
            340                 345                 350         


Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu 
        355                 360                 365             


Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys 
    370                 375                 380                 


Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys 
385                 390                 395                 400 


Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu 
                405                 410                 415     


Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser 
            420                 425                 430         


Asp Asn Glu Ser 
        435     


<210>  32
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Thr Leu 
    130                 135                 140                 


Glu Gly Gln Leu Ser Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Met Leu Ser Glu 
                245                 250                 255     


Arg Met Leu Lys Ala Leu Asn Asp Gln Leu Asn Arg Glu Leu Tyr Ser 
            260                 265                 270         


Ala Tyr Leu Tyr Phe Ala Met Ala Ala Tyr Phe Glu Asp Leu Gly Leu 
        275                 280                 285             


Glu Gly Phe Ala Asn Trp Met Lys Ala Gln Ala Glu Glu Glu Ile Gly 
    290                 295                 300                 


His Ala Leu Arg Phe Tyr Asn Tyr Ile Tyr Asp Arg Asn Gly Arg Val 
305                 310                 315                 320 


Glu Leu Asp Glu Ile Pro Lys Pro Pro Lys Glu Trp Glu Ser Pro Leu 
                325                 330                 335     


Lys Ala Phe Glu Ala Ala Tyr Glu His Glu Lys Phe Ile Ser Lys Ser 
            340                 345                 350         


Ile Tyr Glu Leu Ala Ala Leu Ala Glu Glu Glu Lys Asp Tyr Ser Thr 
        355                 360                 365             


Arg Ala Phe Leu Glu Trp Phe Ile Asn Glu Gln Val Glu Glu Glu Ala 
    370                 375                 380                 


Ser Val Lys Lys Ile Leu Asp Lys Leu Lys Phe Ala Lys Asp Ser Pro 
385                 390                 395                 400 


Gln Ile Leu Phe Met Leu Asp Lys Glu Leu Ser Ala Arg Ala Pro Lys 
                405                 410                 415     


Leu Pro Gly Leu Leu Met Gln Gly Gly Glu 
            420                 425     


<210>  33
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Asp Leu 
    130                 135                 140                 


Lys Gly Glu Leu Ser Ser Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Met Leu Ser Glu 
                245                 250                 255     


Arg Met Leu Lys Ala Leu Asn Asp Gln Leu Asn Arg Glu Leu Tyr Ser 
            260                 265                 270         


Ala Tyr Leu Tyr Phe Ala Met Ala Ala Tyr Phe Glu Asp Leu Gly Leu 
        275                 280                 285             


Glu Gly Phe Ala Asn Trp Met Lys Ala Gln Ala Glu Glu Glu Ile Gly 
    290                 295                 300                 


His Ala Leu Arg Phe Tyr Asn Tyr Ile Tyr Asp Arg Asn Gly Arg Val 
305                 310                 315                 320 


Glu Leu Asp Glu Ile Pro Lys Pro Pro Lys Glu Trp Glu Ser Pro Leu 
                325                 330                 335     


Lys Ala Phe Glu Ala Ala Tyr Glu His Glu Lys Phe Ile Ser Lys Ser 
            340                 345                 350         


Ile Tyr Glu Leu Ala Ala Leu Ala Glu Glu Glu Lys Asp Tyr Ser Thr 
        355                 360                 365             


Arg Ala Phe Leu Glu Trp Phe Ile Asn Glu Gln Val Glu Glu Glu Ala 
    370                 375                 380                 


Ser Val Lys Lys Ile Leu Asp Lys Leu Lys Phe Ala Lys Asp Ser Pro 
385                 390                 395                 400 


Gln Ile Leu Phe Met Leu Asp Lys Glu Leu Ser Ala Arg Ala Pro Lys 
                405                 410                 415     


Leu Pro Gly Leu Leu Met Gln Gly Gly Glu 
            420                 425     


<210>  34
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Thr Leu 
    130                 135                 140                 


Glu Gly Lys Val Ala Asn Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Met Leu Ser Glu 
                245                 250                 255     


Arg Met Leu Lys Ala Leu Asn Asp Gln Leu Asn Arg Glu Leu Tyr Ser 
            260                 265                 270         


Ala Tyr Leu Tyr Phe Ala Met Ala Ala Tyr Phe Glu Asp Leu Gly Leu 
        275                 280                 285             


Glu Gly Phe Ala Asn Trp Met Lys Ala Gln Ala Glu Glu Glu Ile Gly 
    290                 295                 300                 


His Ala Leu Arg Phe Tyr Asn Tyr Ile Tyr Asp Arg Asn Gly Arg Val 
305                 310                 315                 320 


Glu Leu Asp Glu Ile Pro Lys Pro Pro Lys Glu Trp Glu Ser Pro Leu 
                325                 330                 335     


Lys Ala Phe Glu Ala Ala Tyr Glu His Glu Lys Phe Ile Ser Lys Ser 
            340                 345                 350         


Ile Tyr Glu Leu Ala Ala Leu Ala Glu Glu Glu Lys Asp Tyr Ser Thr 
        355                 360                 365             


Arg Ala Phe Leu Glu Trp Phe Ile Asn Glu Gln Val Glu Glu Glu Ala 
    370                 375                 380                 


Ser Val Lys Lys Ile Leu Asp Lys Leu Lys Phe Ala Lys Asp Ser Pro 
385                 390                 395                 400 


Gln Ile Leu Phe Met Leu Asp Lys Glu Leu Ser Ala Arg Ala Pro Lys 
                405                 410                 415     


Leu Pro Gly Leu Leu Met Gln Gly Gly Glu 
            420                 425     


<210>  35
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Met Leu Ser Glu 
                245                 250                 255     


Arg Met Leu Lys Ala Leu Asn Asp Gln Leu Asn Arg Glu Leu Tyr Ser 
            260                 265                 270         


Ala Tyr Leu Tyr Phe Ala Met Ala Ala Tyr Phe Glu Asp Leu Gly Leu 
        275                 280                 285             


Glu Gly Phe Ala Asn Trp Met Lys Ala Gln Ala Glu Glu Glu Ile Gly 
    290                 295                 300                 


His Ala Leu Arg Phe Tyr Asn Tyr Ile Tyr Asp Arg Asn Gly Arg Val 
305                 310                 315                 320 


Glu Leu Asp Glu Ile Pro Lys Pro Pro Lys Glu Trp Glu Ser Pro Leu 
                325                 330                 335     


Lys Ala Phe Glu Ala Ala Tyr Glu His Glu Lys Phe Ile Ser Lys Ser 
            340                 345                 350         


Ile Tyr Glu Leu Ala Ala Leu Ala Glu Glu Glu Lys Asp Tyr Ser Thr 
        355                 360                 365             


Arg Ala Phe Leu Glu Trp Phe Ile Asn Glu Gln Val Glu Glu Glu Ala 
    370                 375                 380                 


Ser Val Lys Lys Ile Leu Asp Lys Leu Lys Phe Ala Lys Asp Ser Pro 
385                 390                 395                 400 


Gln Ile Leu Phe Met Leu Asp Lys Glu Leu Ser Ala Arg Ala Pro Lys 
                405                 410                 415     


Leu Pro Gly Leu Leu Met Gln Gly Gly Glu 
            420                 425     


<210>  36
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Met Asp Glu Lys Asn Ser Ala Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Lys 
            20                  25                  30          


Ala Thr Val Asp Lys Ile Glu Leu Lys Gly Thr Ser Asp Lys Asp Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Thr Lys Asp Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ala Asp Asp Leu Ser Lys Thr Thr Phe Glu Leu Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Arg Lys Val Ser Ser Lys Asp Lys 
                85                  90                  95      


Thr Ser Thr Asp Glu Met Phe Asn Glu Lys Gly Glu Leu Ser Ala Lys 
            100                 105                 110         


Thr Met Thr Arg Glu Asn Gly Thr Lys Leu Glu Tyr Thr Glu Met Lys 
        115                 120                 125             


Ser Asp Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asn Phe Thr Leu 
    130                 135                 140                 


Glu Gly Lys Val Ala Asn Asp Lys Val Thr Leu Glu Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Glu Ile Ala Lys Ser Gly Glu Val Thr Val 
                165                 170                 175     


Ala Leu Asn Asp Thr Asn Thr Thr Gln Ala Thr Lys Lys Thr Gly Ala 
            180                 185                 190         


Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Thr Gln Leu Val Phe Thr Lys Gln Asp Thr Ile Thr Val Gln Lys 
    210                 215                 220                 


Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Thr Ala Val Glu Ile Lys 
225                 230                 235                 240 


Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys Gly Ser Met Leu Ser Glu 
                245                 250                 255     


Arg Met Leu Lys Ala Leu Asn Asp Gln Leu Asn Arg Glu Leu Tyr Ser 
            260                 265                 270         


Ala Tyr Leu Tyr Phe Ala Met Ala Ala Tyr Phe Glu Asp Leu Gly Leu 
        275                 280                 285             


Glu Gly Phe Ala Asn Trp Met Lys Ala Gln Ala Glu Glu Glu Ile Gly 
    290                 295                 300                 


His Ala Leu Arg Phe Tyr Asn Tyr Ile Tyr Asp Arg Asn Gly Arg Val 
305                 310                 315                 320 


Glu Leu Asp Glu Ile Pro Lys Pro Pro Lys Glu Trp Glu Ser Pro Leu 
                325                 330                 335     


Lys Ala Phe Glu Ala Ala Tyr Glu His Glu Lys Phe Ile Ser Lys Ser 
            340                 345                 350         


Ile Tyr Glu Leu Ala Ala Leu Ala Glu Glu Glu Lys Asp Tyr Ser Thr 
        355                 360                 365             


Arg Ala Phe Leu Glu Trp Phe Ile Asn Glu Gln Val Glu Glu Glu Ala 
    370                 375                 380                 


Ser Val Lys Lys Ile Leu Asp Lys Leu Lys Phe Ala Lys Asp Ser Pro 
385                 390                 395                 400 


Gln Ile Leu Phe Met Leu Asp Lys Glu Leu Ser Ala Arg Ala Pro Lys 
                405                 410                 415     


Leu Pro Gly Leu Leu Met Gln Gly Gly Glu 
            420                 425     


<210>  37
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Glu Lys Ala Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ser Gln Asp Leu Asn Gln Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Arg Lys Val Asn Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys 
            100                 105                 110         


Val Val Thr Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys 
        115                 120                 125             


Asn Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Asp Gly Gly Glu Thr Lys Leu Thr Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Ala Leu Asn Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Thr Gly 
            180                 185                 190         


Glu Trp Lys Ser Asp Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln 
        195                 200                 205             


Lys Pro Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln 
    210                 215                 220                 


Asn Tyr Asn Arg Ala Gly Asn Ala Leu Glu Gly Ser Pro Ala Glu Ile 
225                 230                 235                 240 


Lys Asp Leu Ala Glu Leu Lys Ala Ala Leu Lys Gly Ser Met Leu Ser 
                245                 250                 255     


Glu Arg Met Leu Lys Ala Leu Asn Asp Gln Leu Asn Arg Glu Leu Tyr 
            260                 265                 270         


Ser Ala Tyr Leu Tyr Phe Ala Met Ala Ala Tyr Phe Glu Asp Leu Gly 
        275                 280                 285             


Leu Glu Gly Phe Ala Asn Trp Met Lys Ala Gln Ala Glu Glu Glu Ile 
    290                 295                 300                 


Gly His Ala Leu Arg Phe Tyr Asn Tyr Ile Tyr Asp Arg Asn Gly Arg 
305                 310                 315                 320 


Val Glu Leu Asp Glu Ile Pro Lys Pro Pro Lys Glu Trp Glu Ser Pro 
                325                 330                 335     


Leu Lys Ala Phe Glu Ala Ala Tyr Glu His Glu Lys Phe Ile Ser Lys 
            340                 345                 350         


Ser Ile Tyr Glu Leu Ala Ala Leu Ala Glu Glu Glu Lys Asp Tyr Ser 
        355                 360                 365             


Thr Arg Ala Phe Leu Glu Trp Phe Ile Asn Glu Gln Val Glu Glu Glu 
    370                 375                 380                 


Ala Ser Val Lys Lys Ile Leu Asp Lys Leu Lys Phe Ala Lys Asp Ser 
385                 390                 395                 400 


Pro Gln Ile Leu Phe Met Leu Asp Lys Glu Leu Ser Ala Arg Ala Pro 
                405                 410                 415     


Lys Leu Pro Gly Leu Leu Met Gln Gly Gly Glu 
            420                 425         


<210>  38
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Ser Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ser Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Asn Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Ile Glu Glu Lys Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys 
            100                 105                 110         


Thr Ile Leu Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys 
        115                 120                 125             


Ser Asp Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Lys Thr Thr Leu Lys Val Thr Glu Gly 
145                 150                 155                 160 


Thr Val Val Leu Ser Lys His Ile Pro Asn Ser Gly Glu Ile Thr Val 
                165                 170                 175     


Glu Leu Asn Asp Ser Asn Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys 
            180                 185                 190         


Trp Asp Ser Asn Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asn Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys 
    210                 215                 220                 


Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Asn Ala Val Glu Ile Lys 
225                 230                 235                 240 


Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys Gly Ser Met Leu Ser Glu 
                245                 250                 255     


Arg Met Leu Lys Ala Leu Asn Asp Gln Leu Asn Arg Glu Leu Tyr Ser 
            260                 265                 270         


Ala Tyr Leu Tyr Phe Ala Met Ala Ala Tyr Phe Glu Asp Leu Gly Leu 
        275                 280                 285             


Glu Gly Phe Ala Asn Trp Met Lys Ala Gln Ala Glu Glu Glu Ile Gly 
    290                 295                 300                 


His Ala Leu Arg Phe Tyr Asn Tyr Ile Tyr Asp Arg Asn Gly Arg Val 
305                 310                 315                 320 


Glu Leu Asp Glu Ile Pro Lys Pro Pro Lys Glu Trp Glu Ser Pro Leu 
                325                 330                 335     


Lys Ala Phe Glu Ala Ala Tyr Glu His Glu Lys Phe Ile Ser Lys Ser 
            340                 345                 350         


Ile Tyr Glu Leu Ala Ala Leu Ala Glu Glu Glu Lys Asp Tyr Ser Thr 
        355                 360                 365             


Arg Ala Phe Leu Glu Trp Phe Ile Asn Glu Gln Val Glu Glu Glu Ala 
    370                 375                 380                 


Ser Val Lys Lys Ile Leu Asp Lys Leu Lys Phe Ala Lys Asp Ser Pro 
385                 390                 395                 400 


Gln Ile Leu Phe Met Leu Asp Lys Glu Leu Ser Ala Arg Ala Pro Lys 
                405                 410                 415     


Leu Pro Gly Leu Leu Met Gln Gly Gly Glu 
            420                 425     


<210>  39
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ala Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Ile Ser Glu Lys 
            100                 105                 110         


Thr Ile Val Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Ala Leu Asp Asp Ser Asp Thr Thr Gln Ala Thr Lys Lys Thr Gly 
            180                 185                 190         


Lys Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln 
    210                 215                 220                 


Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile 
225                 230                 235                 240 


Thr Thr Leu Glu Lys Leu Lys Asp Ala Leu Lys Gly Ser Met Leu Ser 
                245                 250                 255     


Glu Arg Met Leu Lys Ala Leu Asn Asp Gln Leu Asn Arg Glu Leu Tyr 
            260                 265                 270         


Ser Ala Tyr Leu Tyr Phe Ala Met Ala Ala Tyr Phe Glu Asp Leu Gly 
        275                 280                 285             


Leu Glu Gly Phe Ala Asn Trp Met Lys Ala Gln Ala Glu Glu Glu Ile 
    290                 295                 300                 


Gly His Ala Leu Arg Phe Tyr Asn Tyr Ile Tyr Asp Arg Asn Gly Arg 
305                 310                 315                 320 


Val Glu Leu Asp Glu Ile Pro Lys Pro Pro Lys Glu Trp Glu Ser Pro 
                325                 330                 335     


Leu Lys Ala Phe Glu Ala Ala Tyr Glu His Glu Lys Phe Ile Ser Lys 
            340                 345                 350         


Ser Ile Tyr Glu Leu Ala Ala Leu Ala Glu Glu Glu Lys Asp Tyr Ser 
        355                 360                 365             


Thr Arg Ala Phe Leu Glu Trp Phe Ile Asn Glu Gln Val Glu Glu Glu 
    370                 375                 380                 


Ala Ser Val Lys Lys Ile Leu Asp Lys Leu Lys Phe Ala Lys Asp Ser 
385                 390                 395                 400 


Pro Gln Ile Leu Phe Met Leu Asp Lys Glu Leu Ser Ala Arg Ala Pro 
                405                 410                 415     


Lys Leu Pro Gly Leu Leu Met Gln Gly Gly Glu 
            420                 425         


<210>  40
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Thr 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Ser Thr Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Gly Lys Gly Glu Thr Ser Glu Lys 
            100                 105                 110         


Thr Ile Val Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Ala Ala Leu Asp Asp Ser Asp Thr Thr Arg Ala Thr Lys Lys Thr Gly 
            180                 185                 190         


Lys Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln 
    210                 215                 220                 


Arg Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile 
225                 230                 235                 240 


Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu Lys Gly Ser Met Leu Ser 
                245                 250                 255     


Glu Arg Met Leu Lys Ala Leu Asn Asp Gln Leu Asn Arg Glu Leu Tyr 
            260                 265                 270         


Ser Ala Tyr Leu Tyr Phe Ala Met Ala Ala Tyr Phe Glu Asp Leu Gly 
        275                 280                 285             


Leu Glu Gly Phe Ala Asn Trp Met Lys Ala Gln Ala Glu Glu Glu Ile 
    290                 295                 300                 


Gly His Ala Leu Arg Phe Tyr Asn Tyr Ile Tyr Asp Arg Asn Gly Arg 
305                 310                 315                 320 


Val Glu Leu Asp Glu Ile Pro Lys Pro Pro Lys Glu Trp Glu Ser Pro 
                325                 330                 335     


Leu Lys Ala Phe Glu Ala Ala Tyr Glu His Glu Lys Phe Ile Ser Lys 
            340                 345                 350         


Ser Ile Tyr Glu Leu Ala Ala Leu Ala Glu Glu Glu Lys Asp Tyr Ser 
        355                 360                 365             


Thr Arg Ala Phe Leu Glu Trp Phe Ile Asn Glu Gln Val Glu Glu Glu 
    370                 375                 380                 


Ala Ser Val Lys Lys Ile Leu Asp Lys Leu Lys Phe Ala Lys Asp Ser 
385                 390                 395                 400 


Pro Gln Ile Leu Phe Met Leu Asp Lys Glu Leu Ser Ala Arg Ala Pro 
                405                 410                 415     


Lys Leu Pro Gly Leu Leu Met Gln Gly Gly Glu 
            420                 425         


<210>  41
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Ala Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys 
            100                 105                 110         


Val Val Thr Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Gln 
        115                 120                 125             


Asn Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Ser Leu Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Ala Asp Gly Glu Thr Lys Leu Thr Val Glu Ala 
145                 150                 155                 160 


Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Glu Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Glu Leu Lys Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Ser Gly 
            180                 185                 190         


Thr Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln 
    210                 215                 220                 


Lys Tyr Asn Thr Ala Gly Thr Lys Leu Glu Gly Ser Pro Ala Glu Ile 
225                 230                 235                 240 


Lys Asp Leu Glu Ala Leu Lys Ala Ala Leu Lys Gly Ser Met Leu Ser 
                245                 250                 255     


Glu Arg Met Leu Lys Ala Leu Asn Asp Gln Leu Asn Arg Glu Leu Tyr 
            260                 265                 270         


Ser Ala Tyr Leu Tyr Phe Ala Met Ala Ala Tyr Phe Glu Asp Leu Gly 
        275                 280                 285             


Leu Glu Gly Phe Ala Asn Trp Met Lys Ala Gln Ala Glu Glu Glu Ile 
    290                 295                 300                 


Gly His Ala Leu Arg Phe Tyr Asn Tyr Ile Tyr Asp Arg Asn Gly Arg 
305                 310                 315                 320 


Val Glu Leu Asp Glu Ile Pro Lys Pro Pro Lys Glu Trp Glu Ser Pro 
                325                 330                 335     


Leu Lys Ala Phe Glu Ala Ala Tyr Glu His Glu Lys Phe Ile Ser Lys 
            340                 345                 350         


Ser Ile Tyr Glu Leu Ala Ala Leu Ala Glu Glu Glu Lys Asp Tyr Ser 
        355                 360                 365             


Thr Arg Ala Phe Leu Glu Trp Phe Ile Asn Glu Gln Val Glu Glu Glu 
    370                 375                 380                 


Ala Ser Val Lys Lys Ile Leu Asp Lys Leu Lys Phe Ala Lys Asp Ser 
385                 390                 395                 400 


Pro Gln Ile Leu Phe Met Leu Asp Lys Glu Leu Ser Ala Arg Ala Pro 
                405                 410                 415     


Lys Leu Pro Gly Leu Leu Met Gln Gly Gly Glu 
            420                 425         


<210>  42
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Thr Leu 
    130                 135                 140                 


Glu Gly Gln Leu Ser Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Thr Gln Cys Asn 
                245                 250                 255     


Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg Ser 
            260                 265                 270         


Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser 
        275                 280                 285             


Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val Asn 
    290                 295                 300                 


Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg 
305                 310                 315                 320 


Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu 
                325                 330                 335     


Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser 
            340                 345                 350         


Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met Glu 
        355                 360                 365             


Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp 
    370                 375                 380                 


Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp 
385                 390                 395                 400 


Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala 
                405                 410                 415     


Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe 
            420                 425                 430         


Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
        435                 440             


<210>  43
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Asp Leu 
    130                 135                 140                 


Lys Gly Glu Leu Ser Ser Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Thr Gln Cys Asn 
                245                 250                 255     


Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg Ser 
            260                 265                 270         


Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser 
        275                 280                 285             


Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val Asn 
    290                 295                 300                 


Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg 
305                 310                 315                 320 


Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu 
                325                 330                 335     


Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser 
            340                 345                 350         


Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met Glu 
        355                 360                 365             


Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp 
    370                 375                 380                 


Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp 
385                 390                 395                 400 


Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala 
                405                 410                 415     


Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe 
            420                 425                 430         


Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
        435                 440             


<210>  44
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Thr Leu 
    130                 135                 140                 


Glu Gly Lys Val Ala Asn Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Thr Gln Cys Asn 
                245                 250                 255     


Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg Ser 
            260                 265                 270         


Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser 
        275                 280                 285             


Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val Asn 
    290                 295                 300                 


Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg 
305                 310                 315                 320 


Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu 
                325                 330                 335     


Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser 
            340                 345                 350         


Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met Glu 
        355                 360                 365             


Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp 
    370                 375                 380                 


Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp 
385                 390                 395                 400 


Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala 
                405                 410                 415     


Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe 
            420                 425                 430         


Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
        435                 440             


<210>  45
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Thr Gln Cys Asn 
                245                 250                 255     


Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg Ser 
            260                 265                 270         


Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser 
        275                 280                 285             


Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val Asn 
    290                 295                 300                 


Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg 
305                 310                 315                 320 


Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu 
                325                 330                 335     


Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser 
            340                 345                 350         


Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met Glu 
        355                 360                 365             


Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp 
    370                 375                 380                 


Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp 
385                 390                 395                 400 


Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala 
                405                 410                 415     


Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe 
            420                 425                 430         


Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
        435                 440             


<210>  46
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Met Asp Glu Lys Asn Ser Ala Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Lys 
            20                  25                  30          


Ala Thr Val Asp Lys Ile Glu Leu Lys Gly Thr Ser Asp Lys Asp Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Thr Lys Asp Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ala Asp Asp Leu Ser Lys Thr Thr Phe Glu Leu Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Arg Lys Val Ser Ser Lys Asp Lys 
                85                  90                  95      


Thr Ser Thr Asp Glu Met Phe Asn Glu Lys Gly Glu Leu Ser Ala Lys 
            100                 105                 110         


Thr Met Thr Arg Glu Asn Gly Thr Lys Leu Glu Tyr Thr Glu Met Lys 
        115                 120                 125             


Ser Asp Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asn Phe Thr Leu 
    130                 135                 140                 


Glu Gly Lys Val Ala Asn Asp Lys Val Thr Leu Glu Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Glu Ile Ala Lys Ser Gly Glu Val Thr Val 
                165                 170                 175     


Ala Leu Asn Asp Thr Asn Thr Thr Gln Ala Thr Lys Lys Thr Gly Ala 
            180                 185                 190         


Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Thr Gln Leu Val Phe Thr Lys Gln Asp Thr Ile Thr Val Gln Lys 
    210                 215                 220                 


Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Thr Ala Val Glu Ile Lys 
225                 230                 235                 240 


Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys Gly Ser Thr Gln Cys Asn 
                245                 250                 255     


Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg Ser 
            260                 265                 270         


Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser 
        275                 280                 285             


Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val Asn 
    290                 295                 300                 


Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg 
305                 310                 315                 320 


Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu 
                325                 330                 335     


Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser 
            340                 345                 350         


Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met Glu 
        355                 360                 365             


Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp 
    370                 375                 380                 


Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp 
385                 390                 395                 400 


Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala 
                405                 410                 415     


Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe 
            420                 425                 430         


Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
        435                 440             


<210>  47
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Glu Lys Ala Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ser Gln Asp Leu Asn Gln Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Arg Lys Val Asn Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys 
            100                 105                 110         


Val Val Thr Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys 
        115                 120                 125             


Asn Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Asp Gly Gly Glu Thr Lys Leu Thr Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Ala Leu Asn Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Thr Gly 
            180                 185                 190         


Glu Trp Lys Ser Asp Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln 
        195                 200                 205             


Lys Pro Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln 
    210                 215                 220                 


Asn Tyr Asn Arg Ala Gly Asn Ala Leu Glu Gly Ser Pro Ala Glu Ile 
225                 230                 235                 240 


Lys Asp Leu Ala Glu Leu Lys Ala Ala Leu Lys Gly Ser Thr Gln Cys 
                245                 250                 255     


Asn Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg 
            260                 265                 270         


Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala 
        275                 280                 285             


Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val 
    290                 295                 300                 


Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu 
305                 310                 315                 320 


Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu 
                325                 330                 335     


Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg 
            340                 345                 350         


Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met 
        355                 360                 365             


Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu 
    370                 375                 380                 


Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly 
385                 390                 395                 400 


Asp Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys 
                405                 410                 415     


Ala Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu 
            420                 425                 430         


Phe Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
        435                 440                 


<210>  48
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Ser Asp Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ser Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Asn Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Ile Glu Glu Lys Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys 
            100                 105                 110         


Thr Ile Leu Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys 
        115                 120                 125             


Ser Asp Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Lys Thr Thr Leu Lys Val Thr Glu Gly 
145                 150                 155                 160 


Thr Val Val Leu Ser Lys His Ile Pro Asn Ser Gly Glu Ile Thr Val 
                165                 170                 175     


Glu Leu Asn Asp Ser Asn Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys 
            180                 185                 190         


Trp Asp Ser Asn Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asn Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys 
    210                 215                 220                 


Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Asn Ala Val Glu Ile Lys 
225                 230                 235                 240 


Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys Gly Ser Thr Gln Cys Asn 
                245                 250                 255     


Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg Ser 
            260                 265                 270         


Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser 
        275                 280                 285             


Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val Asn 
    290                 295                 300                 


Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg 
305                 310                 315                 320 


Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu 
                325                 330                 335     


Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser 
            340                 345                 350         


Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met Glu 
        355                 360                 365             


Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp 
    370                 375                 380                 


Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp 
385                 390                 395                 400 


Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala 
                405                 410                 415     


Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe 
            420                 425                 430         


Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
        435                 440             


<210>  49
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met 
            20                  25                  30          


Ala Thr Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ala Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Ile Ser Glu Lys 
            100                 105                 110         


Thr Ile Val Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Ala Leu Asp Asp Ser Asp Thr Thr Gln Ala Thr Lys Lys Thr Gly 
            180                 185                 190         


Lys Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln 
    210                 215                 220                 


Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile 
225                 230                 235                 240 


Thr Thr Leu Glu Lys Leu Lys Asp Ala Leu Lys Gly Ser Thr Gln Cys 
                245                 250                 255     


Asn Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg 
            260                 265                 270         


Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala 
        275                 280                 285             


Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val 
    290                 295                 300                 


Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu 
305                 310                 315                 320 


Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu 
                325                 330                 335     


Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg 
            340                 345                 350         


Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met 
        355                 360                 365             


Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu 
    370                 375                 380                 


Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly 
385                 390                 395                 400 


Asp Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys 
                405                 410                 415     


Ala Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu 
            420                 425                 430         


Phe Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
        435                 440                 


<210>  50
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Thr 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Ser Thr Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Gly Lys Gly Glu Thr Ser Glu Lys 
            100                 105                 110         


Thr Ile Val Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu 
145                 150                 155                 160 


Gly Thr Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr 
                165                 170                 175     


Ala Ala Leu Asp Asp Ser Asp Thr Thr Arg Ala Thr Lys Lys Thr Gly 
            180                 185                 190         


Lys Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln 
    210                 215                 220                 


Arg Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile 
225                 230                 235                 240 


Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu Lys Gly Ser Thr Gln Cys 
                245                 250                 255     


Asn Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg 
            260                 265                 270         


Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala 
        275                 280                 285             


Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val 
    290                 295                 300                 


Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu 
305                 310                 315                 320 


Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu 
                325                 330                 335     


Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg 
            340                 345                 350         


Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met 
        355                 360                 365             


Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu 
    370                 375                 380                 


Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly 
385                 390                 395                 400 


Asp Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys 
                405                 410                 415     


Ala Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu 
            420                 425                 430         


Phe Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
        435                 440                 


<210>  51
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Ala Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys 
            100                 105                 110         


Val Val Thr Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Gln 
        115                 120                 125             


Asn Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Ser Leu Thr Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Ala Asp Gly Glu Thr Lys Leu Thr Val Glu Ala 
145                 150                 155                 160 


Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Glu Ser Gly Glu Ile Thr 
                165                 170                 175     


Val Glu Leu Lys Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Ser Gly 
            180                 185                 190         


Thr Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln 
        195                 200                 205             


Lys Thr Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln 
    210                 215                 220                 


Lys Tyr Asn Thr Ala Gly Thr Lys Leu Glu Gly Ser Pro Ala Glu Ile 
225                 230                 235                 240 


Lys Asp Leu Glu Ala Leu Lys Ala Ala Leu Lys Gly Ser Thr Gln Cys 
                245                 250                 255     


Asn Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg 
            260                 265                 270         


Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala 
        275                 280                 285             


Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val 
    290                 295                 300                 


Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu 
305                 310                 315                 320 


Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu 
                325                 330                 335     


Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg 
            340                 345                 350         


Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met 
        355                 360                 365             


Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu 
    370                 375                 380                 


Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly 
385                 390                 395                 400 


Asp Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys 
                405                 410                 415     


Ala Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu 
            420                 425                 430         


Phe Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
        435                 440                 


<210>  52
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
    130                 135                 140                 


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Thr Leu Glu Gly 
                165                 170                 175     


Gln Leu Ser Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu 
        195                 200                 205             


Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
    210                 215                 220                 


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
                245                 250                 255     


Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
            260                 265                 270         


Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  53
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
    130                 135                 140                 


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Thr Leu Glu Gly 
                165                 170                 175     


Gln Leu Ser Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Gln Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu 
        195                 200                 205             


Gln Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
    210                 215                 220                 


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
                245                 250                 255     


Ser Gln Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
            260                 265                 270         


Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  54
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  54

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
    130                 135                 140                 


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Thr Leu Glu Gly 
                165                 170                 175     


Lys Val Ala Asn Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu 
        195                 200                 205             


Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
    210                 215                 220                 


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
                245                 250                 255     


Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
            260                 265                 270         


Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  55
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  55

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
    130                 135                 140                 


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Thr Leu Glu Gly 
                165                 170                 175     


Lys Val Ala Asn Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Gln Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu 
        195                 200                 205             


Gln Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
    210                 215                 220                 


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
                245                 250                 255     


Ser Gln Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
            260                 265                 270         


Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  56
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
    130                 135                 140                 


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu Glu Gly 
                165                 170                 175     


Thr Leu Thr Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu 
        195                 200                 205             


Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
    210                 215                 220                 


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
                245                 250                 255     


Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
            260                 265                 270         


Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  57
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
    130                 135                 140                 


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu Glu Gly 
                165                 170                 175     


Thr Leu Thr Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Gln Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu 
        195                 200                 205             


Gln Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
    210                 215                 220                 


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
                245                 250                 255     


Ser Gln Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
            260                 265                 270         


Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  58
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
    130                 135                 140                 


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Asp Leu Lys Gly 
                165                 170                 175     


Glu Leu Ser Ser Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu 
        195                 200                 205             


Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
    210                 215                 220                 


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
                245                 250                 255     


Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
            260                 265                 270         


Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  59
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
    130                 135                 140                 


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Asp Leu Lys Gly 
                165                 170                 175     


Glu Leu Ser Ser Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Gln Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu 
        195                 200                 205             


Gln Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
    210                 215                 220                 


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
                245                 250                 255     


Ser Gln Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
            260                 265                 270         


Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  60
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  60

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
    130                 135                 140                 


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Thr Leu Glu Gly 
                165                 170                 175     


Gln Leu Ser Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Gln Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu 
        195                 200                 205             


Gln Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
    210                 215                 220                 


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
                245                 250                 255     


Ser Gln Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
            260                 265                 270         


Asp Glu Ile Lys Asn Ala Leu Lys Gly Gly Gly Ser Glu Ser Gln Val 
        275                 280                 285             


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
    290                 295                 300                 


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
305                 310                 315                 320 


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
                325                 330                 335     


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
            340                 345                 350         


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
        355                 360                 365             


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
    370                 375                 380                 


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
385                 390                 395                 400 


Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
                405                 410                 415     


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
            420                 425                 430         


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
        435                 440                 445             


Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    450                 455         


<210>  61
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
    130                 135                 140                 


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Thr Leu Glu Gly 
                165                 170                 175     


Gln Leu Ser Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Gln Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu 
        195                 200                 205             


Gln Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
    210                 215                 220                 


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
                245                 250                 255     


Ser Gln Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
            260                 265                 270         


Asp Glu Ile Lys Asn Ala Leu Lys Gly Gly Gly Ser Gly Gly Gly Ser 
        275                 280                 285             


Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
    290                 295                 300                 


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
305                 310                 315                 320 


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
                325                 330                 335     


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
            340                 345                 350         


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
        355                 360                 365             


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
    370                 375                 380                 


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
385                 390                 395                 400 


His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
                405                 410                 415     


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
            420                 425                 430         


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
        435                 440                 445             


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    450                 455                 460     


<210>  62
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  62

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
    130                 135                 140                 


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Thr Leu Glu Gly 
                165                 170                 175     


Gln Leu Ser Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Gln Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu 
        195                 200                 205             


Gln Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
    210                 215                 220                 


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
                245                 250                 255     


Ser Gln Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
            260                 265                 270         


Asp Glu Ile Lys Asn Ala Leu Lys Gly Gly Gly Ser Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Ser Gln Val 
    290                 295                 300                 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
305                 310                 315                 320 


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
                325                 330                 335     


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
            340                 345                 350         


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
        355                 360                 365             


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
    370                 375                 380                 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
385                 390                 395                 400 


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
                405                 410                 415     


Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
            420                 425                 430         


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
        435                 440                 445             


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
    450                 455                 460                 


Lys Gly Ile Ala Lys Ser Arg Lys Ser 
465                 470             


<210>  63
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  63

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ala 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
    130                 135                 140                 


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Thr Leu Glu Gly 
                165                 170                 175     


Gln Leu Ser Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Asn Ile Ala Lys Ser Gly Glu Val Ser Val Glu Leu 
        195                 200                 205             


Asn Asp Ala Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
    210                 215                 220                 


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
                245                 250                 255     


Ser Asn Gly Ala Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
            260                 265                 270         


Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  64
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  64

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
    130                 135                 140                 


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Val Leu Glu Gly 
                165                 170                 175     


Thr Leu Thr Ala Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu 
        195                 200                 205             


Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
    210                 215                 220                 


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
                245                 250                 255     


Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
            260                 265                 270         


Asp Glu Ile Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  65
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  65

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Ala Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Lys Ala Thr 
    50                  55                  60                  


Val Asp Lys Ile Glu Leu Lys Gly Thr Ser Asp Lys Asp Asn Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Thr Lys Asp Asp Lys Ser Lys Ala Lys Leu Thr 
                85                  90                  95      


Ile Ala Asp Asp Leu Ser Lys Thr Thr Phe Glu Leu Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Arg Lys Val Ser Ser Lys Asp Lys Thr Ser 
        115                 120                 125             


Thr Asp Glu Met Phe Asn Glu Lys Gly Glu Leu Ser Ala Lys Thr Met 
    130                 135                 140                 


Thr Arg Glu Asn Gly Thr Lys Leu Glu Tyr Thr Glu Met Lys Ser Asp 
145                 150                 155                 160 


Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asn Phe Thr Leu Glu Gly 
                165                 170                 175     


Lys Val Ala Asn Asp Lys Val Thr Leu Glu Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Glu Ile Ala Lys Ser Gly Glu Val Thr Val Ala Leu 
        195                 200                 205             


Asn Asp Thr Asn Thr Thr Gln Ala Thr Lys Lys Thr Gly Ala Trp Asp 
    210                 215                 220                 


Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Thr 
225                 230                 235                 240 


Gln Leu Val Phe Thr Lys Gln Asp Thr Ile Thr Val Gln Lys Tyr Asp 
                245                 250                 255     


Ser Ala Gly Thr Asn Leu Glu Gly Thr Ala Val Glu Ile Lys Thr Leu 
            260                 265                 270         


Asp Glu Leu Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  66
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  66

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Ala Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Lys Ala Thr 
    50                  55                  60                  


Val Asp Lys Ile Glu Leu Lys Gly Thr Ser Asp Lys Asp Gln Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Thr Lys Asp Asp Lys Ser Lys Ala Lys Leu Thr 
                85                  90                  95      


Ile Ala Asp Asp Leu Ser Lys Thr Thr Phe Glu Leu Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Arg Lys Val Ser Ser Lys Asp Lys Thr Ser 
        115                 120                 125             


Thr Asp Glu Met Phe Asn Glu Lys Gly Glu Leu Ser Ala Lys Thr Met 
    130                 135                 140                 


Thr Arg Glu Gln Gly Thr Lys Leu Glu Tyr Thr Glu Met Lys Ser Asp 
145                 150                 155                 160 


Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Gln Phe Thr Leu Glu Gly 
                165                 170                 175     


Lys Val Ala Asn Asp Lys Val Thr Leu Glu Val Lys Glu Gly Thr Val 
            180                 185                 190         


Thr Leu Ser Lys Glu Ile Ala Lys Ser Gly Glu Val Thr Val Ala Leu 
        195                 200                 205             


Gln Asp Thr Gln Thr Thr Gln Ala Thr Lys Lys Thr Gly Ala Trp Asp 
    210                 215                 220                 


Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Thr 
225                 230                 235                 240 


Gln Leu Val Phe Thr Lys Gln Asp Thr Ile Thr Val Gln Lys Tyr Asp 
                245                 250                 255     


Ser Ala Gly Thr Asn Leu Glu Gly Thr Ala Val Glu Ile Lys Thr Leu 
            260                 265                 270         


Asp Glu Leu Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  67
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  67

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met Ala Thr 
    50                  55                  60                  


Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Glu Lys Ala Asp Lys Ser Lys Ala Lys Leu Thr 
                85                  90                  95      


Ile Ser Gln Asp Leu Asn Gln Thr Thr Phe Glu Ile Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Arg Lys Val Asn Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys Val Val 
    130                 135                 140                 


Thr Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Asn Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu Glu Gly 
                165                 170                 175     


Thr Leu Thr Asp Gly Gly Glu Thr Lys Leu Thr Val Thr Glu Gly Thr 
            180                 185                 190         


Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr Val Ala 
        195                 200                 205             


Leu Asn Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Thr Gly Glu Trp 
    210                 215                 220                 


Lys Ser Asp Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln Lys Pro 
225                 230                 235                 240 


Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Asn Tyr 
                245                 250                 255     


Asn Arg Ala Gly Asn Ala Leu Glu Gly Ser Pro Ala Glu Ile Lys Asp 
            260                 265                 270         


Leu Ala Glu Leu Lys Ala Ala Leu Lys Gly Ser Glu Ser Gln Val Arg 
        275                 280                 285             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    290                 295                 300                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser 
305                 310                 315                 320 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                325                 330                 335     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            340                 345                 350         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        355                 360                 365             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    370                 375                 380                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys 
385                 390                 395                 400 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                405                 410                 415     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            420                 425                 430         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        435                 440                 445             


Gly Ile Ala Lys Ser Arg Lys Ser 
    450                 455     


<210>  68
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  68

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met Ala Thr 
    50                  55                  60                  


Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Gln Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Glu Lys Ala Asp Lys Ser Lys Ala Lys Leu Thr 
                85                  90                  95      


Ile Ser Gln Asp Leu Gln Gln Thr Thr Phe Glu Ile Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Arg Lys Val Asn Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys Val Val 
    130                 135                 140                 


Thr Arg Ala Gln Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Asn Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu Glu Gly 
                165                 170                 175     


Thr Leu Thr Asp Gly Gly Glu Thr Lys Leu Thr Val Thr Glu Gly Thr 
            180                 185                 190         


Val Thr Leu Ser Lys Gln Ile Ser Lys Ser Gly Glu Ile Thr Val Ala 
        195                 200                 205             


Leu Gln Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Thr Gly Glu Trp 
    210                 215                 220                 


Lys Ser Asp Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln Lys Pro 
225                 230                 235                 240 


Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Asn Tyr 
                245                 250                 255     


Asn Arg Ala Gly Asn Ala Leu Glu Gly Ser Pro Ala Glu Ile Lys Asp 
            260                 265                 270         


Leu Ala Glu Leu Lys Ala Ala Leu Lys Gly Ser Glu Ser Gln Val Arg 
        275                 280                 285             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    290                 295                 300                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser 
305                 310                 315                 320 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                325                 330                 335     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            340                 345                 350         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        355                 360                 365             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    370                 375                 380                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys 
385                 390                 395                 400 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                405                 410                 415     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            420                 425                 430         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        435                 440                 445             


Gly Ile Ala Lys Ser Arg Lys Ser 
    450                 455     


<210>  69
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  69

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn Gly Ser 
65                  70                  75                  80  


Gly Thr Leu Glu Gly Glu Lys Ser Asp Lys Ser Lys Ala Lys Leu Thr 
                85                  90                  95      


Ile Ser Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Asn Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Ile Glu Glu Lys Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys Thr Ile 
    130                 135                 140                 


Leu Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Ala Leu Glu Gly 
                165                 170                 175     


Thr Leu Ala Ala Asp Lys Thr Thr Leu Lys Val Thr Glu Gly Thr Val 
            180                 185                 190         


Val Leu Ser Lys His Ile Pro Asn Ser Gly Glu Ile Thr Val Glu Leu 
        195                 200                 205             


Asn Asp Ser Asn Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp 
    210                 215                 220                 


Ser Asn Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asn Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp 
                245                 250                 255     


Ser Ala Gly Thr Asn Leu Glu Gly Asn Ala Val Glu Ile Lys Thr Leu 
            260                 265                 270         


Asp Glu Leu Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  70
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  70

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Ser Gln Gly Ser 
65                  70                  75                  80  


Gly Thr Leu Glu Gly Glu Lys Ser Asp Lys Ser Lys Ala Lys Leu Thr 
                85                  90                  95      


Ile Ser Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Asn Ser Lys Asp Lys Ser Ser 
        115                 120                 125             


Ile Glu Glu Lys Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys Thr Ile 
    130                 135                 140                 


Leu Arg Ala Gln Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Thr Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Ala Leu Glu Gly 
                165                 170                 175     


Thr Leu Ala Ala Asp Lys Thr Thr Leu Lys Val Thr Glu Gly Thr Val 
            180                 185                 190         


Val Leu Ser Lys His Ile Pro Asn Ser Gly Glu Ile Thr Val Glu Leu 
        195                 200                 205             


Gln Asp Ser Gln Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp 
    210                 215                 220                 


Ser Gln Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Lys 
225                 230                 235                 240 


Asn Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp 
                245                 250                 255     


Ser Ala Gly Thr Asn Leu Glu Gly Asn Ala Val Glu Ile Lys Thr Leu 
            260                 265                 270         


Asp Glu Leu Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg Gln 
        275                 280                 285             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    290                 295                 300                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
305                 310                 315                 320 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                325                 330                 335     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            340                 345                 350         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        355                 360                 365             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    370                 375                 380                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
385                 390                 395                 400 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                405                 410                 415     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            420                 425                 430         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        435                 440                 445             


Ile Ala Lys Ser Arg Lys Ser 
    450                 455 


<210>  71
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  71

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met Ala Thr 
    50                  55                  60                  


Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
65                  70                  75                  80  


Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ala Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Ile Ser Glu Lys Thr Ile 
    130                 135                 140                 


Val Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu Glu Gly 
                165                 170                 175     


Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu Gly Thr 
            180                 185                 190         


Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr Val Ala 
        195                 200                 205             


Leu Asp Asp Ser Asp Thr Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp 
    210                 215                 220                 


Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln Lys Thr 
225                 230                 235                 240 


Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys Tyr 
                245                 250                 255     


Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile Thr Thr 
            260                 265                 270         


Leu Glu Lys Leu Lys Asp Ala Leu Lys Gly Ser Glu Ser Gln Val Arg 
        275                 280                 285             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    290                 295                 300                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser 
305                 310                 315                 320 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                325                 330                 335     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            340                 345                 350         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        355                 360                 365             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    370                 375                 380                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys 
385                 390                 395                 400 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                405                 410                 415     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            420                 425                 430         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        435                 440                 445             


Gly Ile Ala Lys Ser Arg Lys Ser 
    450                 455     


<210>  72
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  72

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met Ala Thr 
    50                  55                  60                  


Val Glu Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys Leu Thr 
                85                  90                  95      


Ile Ala Glu Asp Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Ile Ser Glu Lys Thr Ile 
    130                 135                 140                 


Val Arg Ala Gln Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu Glu Gly 
                165                 170                 175     


Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu Gly Thr 
            180                 185                 190         


Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr Val Ala 
        195                 200                 205             


Leu Asp Asp Ser Asp Thr Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp 
    210                 215                 220                 


Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln Lys Thr 
225                 230                 235                 240 


Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys Tyr 
                245                 250                 255     


Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile Thr Thr 
            260                 265                 270         


Leu Glu Lys Leu Lys Asp Ala Leu Lys Gly Ser Glu Ser Gln Val Arg 
        275                 280                 285             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    290                 295                 300                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser 
305                 310                 315                 320 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                325                 330                 335     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            340                 345                 350         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        355                 360                 365             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    370                 375                 380                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys 
385                 390                 395                 400 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                405                 410                 415     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            420                 425                 430         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        435                 440                 445             


Gly Ile Ala Lys Ser Arg Lys Ser 
    450                 455     


<210>  73
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  73

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Thr Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys Ser Thr 
                85                  90                  95      


Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Gly Lys Gly Glu Thr Ser Glu Lys Thr Ile 
    130                 135                 140                 


Val Arg Ala Gln Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu Glu Gly 
                165                 170                 175     


Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu Gly Thr 
            180                 185                 190         


Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr Ala Ala 
        195                 200                 205             


Leu Asp Asp Ser Asp Thr Thr Arg Ala Thr Lys Lys Thr Gly Lys Trp 
    210                 215                 220                 


Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln Lys Thr 
225                 230                 235                 240 


Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Arg Tyr 
                245                 250                 255     


Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile Thr Thr 
            260                 265                 270         


Leu Lys Glu Leu Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg 
        275                 280                 285             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    290                 295                 300                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser 
305                 310                 315                 320 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                325                 330                 335     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            340                 345                 350         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        355                 360                 365             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    370                 375                 380                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys 
385                 390                 395                 400 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                405                 410                 415     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            420                 425                 430         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        435                 440                 445             


Gly Ile Ala Lys Ser Arg Lys Ser 
    450                 455     


<210>  74
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  74

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Gly Met Thr Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
65                  70                  75                  80  


Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys Ser Thr 
                85                  90                  95      


Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Gly Lys Gly Glu Thr Ser Glu Lys Thr Ile 
    130                 135                 140                 


Val Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys Ser Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu Glu Gly 
                165                 170                 175     


Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Glu Gly Thr 
            180                 185                 190         


Val Val Leu Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr Ala Ala 
        195                 200                 205             


Leu Asp Asp Ser Asp Thr Thr Arg Ala Thr Lys Lys Thr Gly Lys Trp 
    210                 215                 220                 


Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Gln Lys Thr 
225                 230                 235                 240 


Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Arg Tyr 
                245                 250                 255     


Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile Thr Thr 
            260                 265                 270         


Leu Lys Glu Leu Lys Asn Ala Leu Lys Gly Ser Glu Ser Gln Val Arg 
        275                 280                 285             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    290                 295                 300                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser 
305                 310                 315                 320 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                325                 330                 335     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            340                 345                 350         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        355                 360                 365             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    370                 375                 380                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys 
385                 390                 395                 400 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                405                 410                 415     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            420                 425                 430         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        435                 440                 445             


Gly Ile Ala Lys Ser Arg Lys Ser 
    450                 455     


<210>  75
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  75

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Ala Lys Ser Lys Ala Lys Leu Thr 
                85                  90                  95      


Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys Val Val 
    130                 135                 140                 


Thr Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Gln Asn Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Ser Leu Thr Leu Glu Gly 
                165                 170                 175     


Thr Leu Thr Ala Asp Gly Glu Thr Lys Leu Thr Val Glu Ala Gly Thr 
            180                 185                 190         


Val Thr Leu Ser Lys Asn Ile Ser Glu Ser Gly Glu Ile Thr Val Glu 
        195                 200                 205             


Leu Lys Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Ser Gly Thr Trp 
    210                 215                 220                 


Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln Lys Thr 
225                 230                 235                 240 


Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Lys Tyr 
                245                 250                 255     


Asn Thr Ala Gly Thr Lys Leu Glu Gly Ser Pro Ala Glu Ile Lys Asp 
            260                 265                 270         


Leu Glu Ala Leu Lys Ala Ala Leu Lys Gly Ser Glu Ser Gln Val Arg 
        275                 280                 285             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    290                 295                 300                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser 
305                 310                 315                 320 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                325                 330                 335     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            340                 345                 350         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        355                 360                 365             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    370                 375                 380                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys 
385                 390                 395                 400 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                405                 410                 415     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            420                 425                 430         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        435                 440                 445             


Gly Ile Ala Lys Ser Arg Lys Ser 
    450                 455     


<210>  76
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  76

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Met Asp 
            20                  25                  30          


Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu 
        35                  40                  45              


Val Ser Lys Glu Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu Ala Thr 
    50                  55                  60                  


Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Leu Glu Gly Val Lys Ala Ala Lys Ser Lys Ala Lys Leu Thr 
                85                  90                  95      


Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys Glu Asp 
            100                 105                 110         


Gly Lys Thr Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys Ser Ser 
        115                 120                 125             


Thr Glu Glu Lys Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys Val Val 
    130                 135                 140                 


Thr Arg Ala Gln Gly Thr Arg Leu Glu Tyr Thr Glu Ile Gln Asn Asp 
145                 150                 155                 160 


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Ser Leu Thr Leu Glu Gly 
                165                 170                 175     


Thr Leu Thr Ala Asp Gly Glu Thr Lys Leu Thr Val Glu Ala Gly Thr 
            180                 185                 190         


Val Thr Leu Ser Lys Gln Ile Ser Glu Ser Gly Glu Ile Thr Val Glu 
        195                 200                 205             


Leu Lys Asp Thr Glu Thr Thr Pro Ala Asp Lys Lys Ser Gly Thr Trp 
    210                 215                 220                 


Asp Ser Lys Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln Lys Thr 
225                 230                 235                 240 


Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Lys Tyr 
                245                 250                 255     


Asn Thr Ala Gly Thr Lys Leu Glu Gly Ser Pro Ala Glu Ile Lys Asp 
            260                 265                 270         


Leu Glu Ala Leu Lys Ala Ala Leu Lys Gly Ser Glu Ser Gln Val Arg 
        275                 280                 285             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    290                 295                 300                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser 
305                 310                 315                 320 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                325                 330                 335     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            340                 345                 350         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        355                 360                 365             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    370                 375                 380                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys 
385                 390                 395                 400 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                405                 410                 415     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            420                 425                 430         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        435                 440                 445             


Gly Ile Ala Lys Ser Arg Lys Ser 
    450                 455     


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  77

Tyr Val Leu Glu Gly Thr Leu Thr Ala 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  78

Tyr Val Ile Glu Gly Thr Ser Lys Gln 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  79

Phe Thr Leu Glu Gly Lys Val Ala Asn 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  80

Phe Ala Leu Glu Gly Thr Leu Thr Asp 
1               5                   


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  81

Tyr Thr Leu Glu Gly Gln Leu Ser Asp 
1               5                   


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  82

Tyr Asp Leu Lys Gly Glu Leu Ser Ser 
1               5                   


<210>  83
<211>  273
<212>  PRT
<213>  Borreliella burgdorferi

<400>  83

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 
        35                  40                  45              


Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 
65                  70                  75                  80  


Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 
                85                  90                  95      


Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 
            100                 105                 110         


Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 
        115                 120                 125             


Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 
                165                 170                 175     


Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 
            180                 185                 190         


Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala 
        195                 200                 205             


Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr 
    210                 215                 220                 


Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu 
225                 230                 235                 240 


Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 
                245                 250                 255     


Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 
            260                 265                 270         


Lys 
    


<210>  84
<211>  273
<212>  PRT
<213>  Borreliella afzelii

<400>  84

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Ala Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Lys Ala Thr Val Asp Lys Ile Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Asp Asn Gly Ser Gly Val Leu Glu Gly Thr Lys 
65                  70                  75                  80  


Asp Asp Lys Ser Lys Ala Lys Leu Thr Ile Ala Asp Asp Leu Ser Lys 
                85                  90                  95      


Thr Thr Phe Glu Leu Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Arg 
            100                 105                 110         


Lys Val Ser Ser Lys Asp Lys Thr Ser Thr Asp Glu Met Phe Asn Glu 
        115                 120                 125             


Lys Gly Glu Leu Ser Ala Lys Thr Met Thr Arg Glu Asn Gly Thr Lys 
    130                 135                 140                 


Leu Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Asn Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys Val 
                165                 170                 175     


Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys Glu Ile Ala 
            180                 185                 190         


Lys Ser Gly Glu Val Thr Val Ala Leu Asn Asp Thr Asn Thr Thr Gln 
        195                 200                 205             


Ala Thr Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr Ser Thr Leu Thr 
    210                 215                 220                 


Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val Phe Thr Lys Gln 
225                 230                 235                 240 


Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 
                245                 250                 255     


Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu 
            260                 265                 270         


Lys 
    


<210>  85
<211>  274
<212>  PRT
<213>  Borreliella garinii

<400>  85

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Gly Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Met Ala Thr Val Glu Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Ser Asn Gly Ser Gly Val Leu Glu Gly Glu Lys 
65                  70                  75                  80  


Ala Asp Lys Ser Lys Ala Lys Leu Thr Ile Ser Gln Asp Leu Asn Gln 
                85                  90                  95      


Thr Thr Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Arg 
            100                 105                 110         


Lys Val Asn Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Asp 
        115                 120                 125             


Lys Gly Lys Leu Ser Glu Lys Val Val Thr Arg Ala Asn Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Glu Ile Lys Asn Asp Gly Ser Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Gly Phe Ala Leu Glu Gly Thr Leu Thr Asp Gly Gly Glu 
                165                 170                 175     


Thr Lys Leu Thr Val Thr Glu Gly Thr Val Thr Leu Ser Lys Asn Ile 
            180                 185                 190         


Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp Thr Glu Thr Thr 
        195                 200                 205             


Pro Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp Thr Ser Thr Leu 
    210                 215                 220                 


Thr Ile Ser Lys Asn Ser Gln Lys Pro Lys Gln Leu Val Phe Thr Lys 
225                 230                 235                 240 


Glu Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala Gly Asn Ala Leu 
                245                 250                 255     


Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu Leu Lys Ala Ala 
            260                 265                 270         


Leu Lys 
        


<210>  86
<211>  273
<212>  PRT
<213>  Borreliella bavariensis

<400>  86

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Met Ala Thr Val Asp Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Ser Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys 
65                  70                  75                  80  


Ser Asp Lys Ser Lys Ala Lys Leu Thr Ile Ser Glu Asp Leu Ser Lys 
                85                  90                  95      


Thr Thr Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 
            100                 105                 110         


Lys Val Asn Ser Lys Asp Lys Ser Ser Ile Glu Glu Lys Phe Asn Ala 
        115                 120                 125             


Lys Gly Glu Leu Ser Glu Lys Thr Ile Leu Arg Ala Asn Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Glu Ile Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Asp Phe Ala Leu Glu Gly Thr Leu Ala Ala Asp Lys Thr 
                165                 170                 175     


Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser Lys His Ile Pro 
            180                 185                 190         


Asn Ser Gly Glu Ile Thr Val Glu Leu Asn Asp Ser Asn Ser Thr Gln 
        195                 200                 205             


Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Asn Thr Ser Thr Leu Thr 
    210                 215                 220                 


Ile Ser Val Asn Ser Lys Lys Thr Lys Asn Ile Val Phe Thr Lys Glu 
225                 230                 235                 240 


Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 
                245                 250                 255     


Gly Asn Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu 
            260                 265                 270         


Lys 
    


<210>  87
<211>  274
<212>  PRT
<213>  Borreliella garinii

<400>  87

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Gly Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Met Ala Thr Val Glu Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys 
65                  70                  75                  80  


Thr Asp Lys Ser Lys Val Lys Leu Thr Ile Ala Glu Asp Leu Ser Lys 
                85                  90                  95      


Thr Thr Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 
            100                 105                 110         


Lys Val Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 
        115                 120                 125             


Lys Gly Glu Ile Ser Glu Lys Thr Ile Val Arg Ala Asn Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Asp Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala Asp Gly Lys 
                165                 170                 175     


Thr Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser Lys Asn Ile 
            180                 185                 190         


Leu Lys Ser Gly Glu Ile Thr Val Ala Leu Asp Asp Ser Asp Thr Thr 
        195                 200                 205             


Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Lys Thr Ser Thr Leu 
    210                 215                 220                 


Thr Ile Ser Val Asn Ser Gln Lys Thr Lys Asn Leu Val Phe Thr Lys 
225                 230                 235                 240 


Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu 
                245                 250                 255     


Glu Gly Lys Ala Val Glu Ile Thr Thr Leu Glu Lys Leu Lys Asp Ala 
            260                 265                 270         


Leu Lys 
        


<210>  88
<211>  274
<212>  PRT
<213>  Borreliella burgdorferi

<400>  88

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Gly Met Thr Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Glu Ala Thr Val Asp Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys 
65                  70                  75                  80  


Thr Asp Lys Ser Lys Val Lys Ser Thr Ile Ala Asp Asp Leu Ser Gln 
                85                  90                  95      


Thr Lys Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 
            100                 105                 110         


Lys Val Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Gly 
        115                 120                 125             


Lys Gly Glu Thr Ser Glu Lys Thr Ile Val Arg Ala Asn Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Asp Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala Asp Gly Lys 
                165                 170                 175     


Thr Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser Lys Asn Ile 
            180                 185                 190         


Leu Lys Ser Gly Glu Ile Thr Ala Ala Leu Asp Asp Ser Asp Thr Thr 
        195                 200                 205             


Arg Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Lys Thr Ser Thr Leu 
    210                 215                 220                 


Thr Ile Ser Val Asn Ser Gln Lys Thr Lys Asn Leu Val Phe Thr Lys 
225                 230                 235                 240 


Glu Asp Thr Ile Thr Val Gln Arg Tyr Asp Ser Ala Gly Thr Asn Leu 
                245                 250                 255     


Glu Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu Lys Asn Ala 
            260                 265                 270         


Leu Lys 
        


<210>  89
<211>  214
<212>  PRT
<213>  Borreliella garinii

<400>  89

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Glu Ala Thr Val Asp Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 
65                  70                  75                  80  


Ala Ala Lys Ser Lys Ala Lys Leu Thr Ile Ala Asp Asp Leu Ser Gln 
                85                  90                  95      


Thr Lys Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 
            100                 105                 110         


Lys Val Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Asp 
        115                 120                 125             


Lys Gly Lys Leu Ser Glu Lys Val Val Thr Arg Ala Asn Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Glu Ile Gln Asn Asp Gly Ser Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Ser Leu Thr Leu Glu Gly Thr Leu Thr Ala Asp Gly Glu 
                165                 170                 175     


Thr Lys Leu Thr Glu Asn Thr Ile Thr Val Gln Lys Tyr Asn Thr Ala 
            180                 185                 190         


Gly Thr Lys Leu Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Glu Ala 
        195                 200                 205             


Leu Lys Ala Ala Leu Lys 
    210                 


<210>  90
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  90

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  91

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  92
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  92

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  93
<211>  154
<212>  PRT
<213>  Aquifex aeolicus

<400>  93

Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly 
1               5                   10                  15      


Ile Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu 
            20                  25                  30          


Gly Ala Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile 
        35                  40                  45              


Thr Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly 
    50                  55                  60                  


Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val 
65                  70                  75                  80  


Leu Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val 
                85                  90                  95      


Ser Lys Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr 
            100                 105                 110         


Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala 
        115                 120                 125             


Gly Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile 
    130                 135                 140                 


Glu Met Ala Asn Leu Phe Lys Ser Leu Arg 
145                 150                 


<210>  94
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  94

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Thr Leu 
    130                 135                 140                 


Glu Gly Gln Leu Ser Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 
                245                 250 


<210>  95
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  95

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Asp Leu 
    130                 135                 140                 


Lys Gly Glu Leu Ser Ser Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 
                245                 250 


<210>  96
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  96

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Thr Leu 
    130                 135                 140                 


Glu Gly Lys Val Ala Asn Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 
                245                 250 


<210>  97
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  97

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 
                245                 250 


<210>  98
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  98

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Thr Leu 
    130                 135                 140                 


Glu Gly Gln Leu Ser Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Gln Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Gln Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Gln Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 
                245                 250 


<210>  99
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  99

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Thr Leu 
    130                 135                 140                 


Glu Gly Lys Val Ala Asn Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Gln Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Gln Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Gln Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 
                245                 250 


<210>  100
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  100

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Ala Leu 
    130                 135                 140                 


Glu Gly Thr Leu Thr Asp Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Gln Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Gln Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Gln Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 
                245                 250 


<210>  101
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  101

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Gln 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Asp Leu 
    130                 135                 140                 


Lys Gly Glu Leu Ser Ser Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Gln Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Gln Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Gln Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 
                245                 250 


<210>  102
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  SITE
<222>  (1)..(250)
<223>  /note="Variant residues given in the sequence have no preference 
       with respect to those in the annotations for variant positions"

<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  /replace="Gln"

<220>
<221>  MOD_RES
<222>  (142)..(150)
<223>  Any amino acid

<220>
<221>  VARIANT
<222>  (167)..(167)
<223>  /replace="Gln"

<220>
<221>  VARIANT
<222>  (179)..(179)
<223>  /replace="Gln"

<220>
<221>  VARIANT
<222>  (228)..(228)
<223>  /replace="Gln"

<400>  102

Met Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys 
1               5                   10                  15      


Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile 
            20                  25                  30          


Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn 
        35                  40                  45              


Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys 
    50                  55                  60                  


Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys 
                85                  90                  95      


Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys 
            100                 105                 110         


Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys 
        115                 120                 125             


Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Glu Lys Thr Thr Leu Val Val Lys Glu Gly 
145                 150                 155                 160 


Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val 
                165                 170                 175     


Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala 
            180                 185                 190         


Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys 
        195                 200                 205             


Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr 
225                 230                 235                 240 


Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 
                245                 250 


<210>  103

<400>  103
000

<210>  104

<400>  104
000

<210>  105

<400>  105
000

<210>  106

<400>  106
000

<210>  107

<400>  107
000

<210>  108

<400>  108
000

<210>  109

<400>  109
000

<210>  110

<400>  110
000

<210>  111

<400>  111
000

<210>  112

<400>  112
000

<210>  113

<400>  113
000

<210>  114

<400>  114
000

<210>  115

<400>  115
000

<210>  116

<400>  116
000

<210>  117

<400>  117
000

<210>  118

<400>  118
000

<210>  119

<400>  119
000

<210>  120

<400>  120
000

<210>  121

<400>  121
000

<210>  122

<400>  122
000

<210>  123

<400>  123
000

<210>  124

<400>  124
000

<210>  125

<400>  125
000

<210>  126

<400>  126
000

<210>  127

<400>  127
000

<210>  128

<400>  128
000

<210>  129

<400>  129
000

<210>  130

<400>  130
000

<210>  131

<400>  131
000

<210>  132

<400>  132
000

<210>  133

<400>  133
000

<210>  134

<400>  134
000

<210>  135

<400>  135
000

<210>  136

<400>  136
000

<210>  137

<400>  137
000

<210>  138

<400>  138
000

<210>  139

<400>  139
000

<210>  140

<400>  140
000

<210>  141

<400>  141
000

<210>  142

<400>  142
000

<210>  143

<400>  143
000

<210>  144

<400>  144
000

<210>  145

<400>  145
000

<210>  146

<400>  146
000

<210>  147

<400>  147
000

<210>  148

<400>  148
000

<210>  149

<400>  149
000

<210>  150

<400>  150
000

<210>  151

<400>  151
000

<210>  152

<400>  152
000

<210>  153

<400>  153
000

<210>  154

<400>  154
000

<210>  155

<400>  155
000

<210>  156

<400>  156
000

<210>  157

<400>  157
000

<210>  158

<400>  158
000

<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161

<400>  161
000

<210>  162

<400>  162
000

<210>  163

<400>  163
000

<210>  164

<400>  164
000

<210>  165

<400>  165
000

<210>  166

<400>  166
000

<210>  167

<400>  167
000

<210>  168

<400>  168
000

<210>  169

<400>  169
000

<210>  170

<400>  170
000

<210>  171

<400>  171
000

<210>  172

<400>  172
000

<210>  173

<400>  173
000

<210>  174

<400>  174
000

<210>  175

<400>  175
000

<210>  176

<400>  176
000

<210>  177

<400>  177
000

<210>  178

<400>  178
000

<210>  179

<400>  179
000

<210>  180

<400>  180
000

<210>  181

<400>  181
000

<210>  182

<400>  182
000

<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187

<400>  187
000

<210>  188

<400>  188
000

<210>  189

<400>  189
000

<210>  190

<400>  190
000

<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194

<400>  194
000

<210>  195

<400>  195
000

<210>  196

<400>  196
000

<210>  197

<400>  197
000

<210>  198

<400>  198
000

<210>  199

<400>  199
000

<210>  200

<400>  200
000

<210>  201
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  201

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Cys 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  202
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  202

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Cys Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  203
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  203

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Cys Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  204
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  204

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Cys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  205
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  205

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Cys Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  206
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  206

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  207
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  207

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Cys Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  208
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  208

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  209
<211>  166
<212>  PRT
<213>  Helicobacter pylori

<400>  209

Leu Ser Lys Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
1               5                   10                  15      


Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr 
            20                  25                  30          


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
        35                  40                  45              


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
    50                  55                  60                  


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
65                  70                  75                  80  


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
                85                  90                  95      


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp 
            100                 105                 110         


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
        115                 120                 125             


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
    130                 135                 140                 


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
145                 150                 155                 160 


Ala Lys Ser Arg Lys Ser 
                165     


<210>  210
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  210
tgactgtgaa cgttcgagat ga                                                22


<210>  211
<211>  191
<212>  PRT
<213>  Trichoplusia ni

<400>  211

Thr Gln Cys Asn Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr 
1               5                   10                  15      


Met His Arg Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu 
            20                  25                  30          


Val Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys 
        35                  40                  45              


Asp Val Val Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala 
    50                  55                  60                  


Ser Glu Glu Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met 
65                  70                  75                  80  


Arg Gly Glu Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro 
                85                  90                  95      


Pro Thr Arg Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala 
            100                 105                 110         


Leu Ser Met Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys 
        115                 120                 125             


Ala Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr 
    130                 135                 140                 


Leu Thr Gly Asp Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu 
145                 150                 155                 160 


Ala Gly Lys Ala Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala 
                165                 170                 175     


Leu Gly Glu Phe Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
            180                 185                 190     


<210>  212
<211>  212
<212>  PRT
<213>  Trichoplusia ni

<400>  212

Ala Asp Thr Cys Tyr Asn Asp Val Ala Leu Asp Cys Gly Ile Thr Ser 
1               5                   10                  15      


Asn Ser Leu Ala Leu Pro Arg Cys Asn Ala Val Tyr Gly Glu Tyr Gly 
            20                  25                  30          


Ser His Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His 
        35                  40                  45              


Leu Glu Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn 
    50                  55                  60                  


Tyr Gln Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser 
65                  70                  75                  80  


Asp Glu Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys 
                85                  90                  95      


Arg Gly Asp Lys Met Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu 
            100                 105                 110         


Arg Lys Asn Tyr Thr Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys 
        115                 120                 125             


Ala Leu Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His 
    130                 135                 140                 


Arg Glu Ala Thr Arg Asn Ser Gln His Leu His Asp Pro Glu Ile Ala 
145                 150                 155                 160 


Gln Tyr Leu Glu Glu Glu Phe Ile Glu Asp His Ala Glu Lys Ile Arg 
                165                 170                 175     


Thr Leu Ala Gly His Thr Ser Asp Leu Lys Lys Phe Ile Thr Ala Asn 
            180                 185                 190         


Asn Gly His Asp Leu Ser Leu Ala Leu Tyr Val Phe Asp Glu Tyr Leu 
        195                 200                 205             


Gln Lys Thr Val 
    210         


<210>  213
<211>  174
<212>  PRT
<213>  Pyrococcus furiosus

<400>  213

Met Leu Ser Glu Arg Met Leu Lys Ala Leu Asn Asp Gln Leu Asn Arg 
1               5                   10                  15      


Glu Leu Tyr Ser Ala Tyr Leu Tyr Phe Ala Met Ala Ala Tyr Phe Glu 
            20                  25                  30          


Asp Leu Gly Leu Glu Gly Phe Ala Asn Trp Met Lys Ala Gln Ala Glu 
        35                  40                  45              


Glu Glu Ile Gly His Ala Leu Arg Phe Tyr Asn Tyr Ile Tyr Asp Arg 
    50                  55                  60                  


Asn Gly Arg Val Glu Leu Asp Glu Ile Pro Lys Pro Pro Lys Glu Trp 
65                  70                  75                  80  


Glu Ser Pro Leu Lys Ala Phe Glu Ala Ala Tyr Glu His Glu Lys Phe 
                85                  90                  95      


Ile Ser Lys Ser Ile Tyr Glu Leu Ala Ala Leu Ala Glu Glu Glu Lys 
            100                 105                 110         


Asp Tyr Ser Thr Arg Ala Phe Leu Glu Trp Phe Ile Asn Glu Gln Val 
        115                 120                 125             


Glu Glu Glu Ala Ser Val Lys Lys Ile Leu Asp Lys Leu Lys Phe Ala 
    130                 135                 140                 


Lys Asp Ser Pro Gln Ile Leu Phe Met Leu Asp Lys Glu Leu Ser Ala 
145                 150                 155                 160 


Arg Ala Pro Lys Leu Pro Gly Leu Leu Met Gln Gly Gly Glu 
                165                 170                 


<210>  214
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Gln 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Gln Glu Ser 
            180             


<210>  215
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Ser Ser 
            20                  25                  30          


Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser 
        35                  40                  45              


Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly 
    50                  55                  60                  


Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe 
65                  70                  75                  80  


Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu 
                85                  90                  95      


Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys 
            100                 105                 110         


Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala 
        115                 120                 125             


Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His 
    130                 135                 140                 


Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu 
145                 150                 155                 160 


Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp 
                165                 170                 175     


His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly 
            180                 185                 190         


Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp 
        195                 200                 


<210>  216
<211>  154
<212>  PRT
<213>  Aquifex aeolicus

<400>  216

Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly 
1               5                   10                  15      


Ile Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu 
            20                  25                  30          


Gly Ala Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile 
        35                  40                  45              


Thr Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly 
    50                  55                  60                  


Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val 
65                  70                  75                  80  


Leu Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val 
                85                  90                  95      


Ser Lys Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr 
            100                 105                 110         


Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala 
        115                 120                 125             


Gly Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile 
    130                 135                 140                 


Glu Met Ala Asn Leu Phe Lys Ser Leu Arg 
145                 150                 


<210>  217
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Bullfrog linker sequence

<400>  217

Glu Ser Gln Val Arg Gln Gln Phe 
1               5               


<210>  218
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  218

Cys Leu Val Pro Arg Gly Ser Leu Glu His His His His His His 
1               5                   10                  15  


<210>  219
<211>  156
<212>  PRT
<213>  Escherichia coli

<400>  219

Met Asn Ile Ile Glu Ala Asn Val Ala Thr Pro Asp Ala Arg Val Ala 
1               5                   10                  15      


Ile Thr Ile Ala Arg Phe Asn Asn Phe Ile Asn Asp Ser Leu Leu Glu 
            20                  25                  30          


Gly Ala Ile Asp Ala Leu Lys Arg Ile Gly Gln Val Lys Asp Glu Asn 
        35                  40                  45              


Ile Thr Val Val Trp Val Pro Gly Ala Tyr Glu Leu Pro Leu Ala Ala 
    50                  55                  60                  


Gly Ala Leu Ala Lys Thr Gly Lys Tyr Asp Ala Val Ile Ala Leu Gly 
65                  70                  75                  80  


Thr Val Ile Arg Gly Gly Thr Ala His Phe Glu Tyr Val Ala Gly Gly 
                85                  90                  95      


Ala Ser Asn Gly Leu Ala His Val Ala Gln Asp Ser Glu Ile Pro Val 
            100                 105                 110         


Ala Phe Gly Val Leu Thr Thr Glu Ser Ile Glu Gln Ala Ile Glu Arg 
        115                 120                 125             


Ala Gly Thr Lys Ala Gly Asn Lys Gly Ala Glu Ala Ala Leu Thr Ala 
    130                 135                 140                 


Leu Glu Met Ile Asn Val Leu Lys Ala Ile Lys Ala 
145                 150                 155     


<210>  220
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  220

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


<210>  221
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  221

Gly Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
            20                  25              


<210>  222
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  222

Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser 
1               5                   10                  15      


Asn Gly Ser Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser Ser Gly 
            20                  25                  30          


Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
        35                  40                  45      


<210>  223
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  223

Gly Gly Ser Gly Ser Ala Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Ala Gly Gly Ser Gly Gly Ser Gly 
            20                  25      


<210>  224
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  224

Gly Gly Ser Gly Ser Ala Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Glu Ala Ala Ala Lys Ala Ser Gly Gly Ser Gly Gly Ser Gly 
            20                  25                  30          


<210>  225
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  225

Ser Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly 
1               5                   10                  15      


Ser Ser Cys Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly 
            20                  25                  30          


Ala Ser Ser Gly Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Gly 
        35                  40                  45          


<210>  226
<211>  1086
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  226

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Leu Ala Tyr 
865                 870                 875                 880 


Phe Leu Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala 
                885                 890                 895     


Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro 
            900                 905                 910         


Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp 
        915                 920                 925             


Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe Gln 
    930                 935                 940                 


Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg 
945                 950                 955                 960 


Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys Lys 
                965                 970                 975     


Lys His Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr Pro 
            980                 985                 990         


Cys Thr Tyr Phe Tyr Gly Pro Thr  Pro Asp Ile Leu Pro  Val Val Thr 
        995                 1000                 1005             


Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp Val Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp Gly Gly  Thr Phe Lys 
    1025                 1030                 1035             


Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr Tyr Val  Ser Lys Phe 
    1040                 1045                 1050             


Ser Thr  Val Pro Val Ser His  His Glu Cys Ser Phe  Leu Lys Pro 
    1055                 1060                 1065             


Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser Gly Ser  His His His 
    1070                 1075                 1080             


His His  His 
    1085     


<210>  227
<211>  1339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  227

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Leu Ala Tyr 
865                 870                 875                 880 


Phe Leu Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala 
                885                 890                 895     


Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro 
            900                 905                 910         


Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp 
        915                 920                 925             


Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe Gln 
    930                 935                 940                 


Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg 
945                 950                 955                 960 


Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys Lys 
                965                 970                 975     


Lys His Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr Pro 
            980                 985                 990         


Cys Thr Tyr Phe Tyr Gly Pro Thr  Pro Asp Ile Leu Pro  Val Val Thr 
        995                 1000                 1005             


Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp Val Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp Gly Gly  Thr Phe Lys 
    1025                 1030                 1035             


Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr Tyr Val  Ser Lys Phe 
    1040                 1045                 1050             


Ser Thr  Val Pro Val Ser His  His Glu Cys Ser Phe  Leu Lys Pro 
    1055                 1060                 1065             


Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser Gly Gly  Ser Gly Ser 
    1070                 1075                 1080             


Ala Ser  Ser Gly Ala Ser Ala  Ser Gly Ser Ser Gly  Ser Gly Ser 
    1085                 1090                 1095             


Gly Ser  Gly Ser Ser Ser Ala  Ser Ser Gly Ala Ser  Ser Gly Gly 
    1100                 1105                 1110             


Ala Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Gly Ser  Gly Ser Ala 
    1115                 1120                 1125             


Ser Ser  Gly Ala Ser Ala Ser  Gly Ser Ser Gly Ser  Gly Ser Gly 
    1130                 1135                 1140             


Ser Gly  Ser Ser Ser Ala Ser  Ser Gly Ala Ser Ser  Gly Gly Ala 
    1145                 1150                 1155             


Ser Gly  Gly Ser Gly Gly Ser  Gly Glu Ser Gln Val  Arg Gln Gln 
    1160                 1165                 1170             


Phe Ser  Lys Asp Ile Glu Lys  Leu Leu Asn Glu Gln  Val Asn Lys 
    1175                 1180                 1185             


Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser Met Ser  Ser Trp Ser 
    1190                 1195                 1200             


Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His 
    1205                 1210                 1215             


Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu 
    1220                 1225                 1230             


Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro 
    1235                 1240                 1245             


Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr 
    1250                 1255                 1260             


Glu His  Glu Gln His Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp 
    1265                 1270                 1275             


His Ala  Ile Lys Cys Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln 
    1280                 1285                 1290             


Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu Val Leu  Phe Lys Asp 
    1295                 1300                 1305             


Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu 
    1310                 1315                 1320             


Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys 
    1325                 1330                 1335             


Ser 
    


<210>  228
<211>  1295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  228

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Leu Ala Tyr 
865                 870                 875                 880 


Phe Leu Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala 
                885                 890                 895     


Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro 
            900                 905                 910         


Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp 
        915                 920                 925             


Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe Gln 
    930                 935                 940                 


Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg 
945                 950                 955                 960 


Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys Lys 
                965                 970                 975     


Lys His Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr Pro 
            980                 985                 990         


Cys Thr Tyr Phe Tyr Gly Pro Thr  Pro Asp Ile Leu Pro  Val Val Thr 
        995                 1000                 1005             


Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp Val Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp Gly Gly  Thr Phe Lys 
    1025                 1030                 1035             


Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr Tyr Val  Ser Lys Phe 
    1040                 1045                 1050             


Ser Thr  Val Pro Val Ser His  His Glu Cys Ser Phe  Leu Lys Pro 
    1055                 1060                 1065             


Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser Gly Gly  Ser Gly Ser 
    1070                 1075                 1080             


Ala Ser  Ser Gly Ala Ser Ala  Ser Gly Ser Ser Gly  Ser Gly Ser 
    1085                 1090                 1095             


Gly Ser  Gly Ser Ser Ser Ala  Ser Ser Gly Ala Ser  Ser Gly Gly 
    1100                 1105                 1110             


Ala Ser  Gly Gly Ser Gly Gly  Ser Gly Glu Ser Gln  Val Arg Gln 
    1115                 1120                 1125             


Gln Phe  Ser Lys Asp Ile Glu  Lys Leu Leu Asn Glu  Gln Val Asn 
    1130                 1135                 1140             


Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met Ser Met  Ser Ser Trp 
    1145                 1150                 1155             


Ser Tyr  Thr His Ser Leu Asp  Gly Ala Gly Leu Phe  Leu Phe Asp 
    1160                 1165                 1170             


His Ala  Ala Glu Glu Tyr Glu  His Ala Lys Lys Leu  Ile Ile Phe 
    1175                 1180                 1185             


Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu Thr Ser  Ile Ser Ala 
    1190                 1195                 1200             


Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln Ile Phe  Gln Lys Ala 
    1205                 1210                 1215             


Tyr Glu  His Glu Gln His Ile  Ser Glu Ser Ile Asn  Asn Ile Val 
    1220                 1225                 1230             


Asp His  Ala Ile Lys Cys Lys  Asp His Ala Thr Phe  Asn Phe Leu 
    1235                 1240                 1245             


Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu Glu Val  Leu Phe Lys 
    1250                 1255                 1260             


Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly 
    1265                 1270                 1275             


Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg 
    1280                 1285                 1290             


Lys Ser  
    1295 


<210>  229
<211>  1263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  229

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Leu Ala Tyr 
865                 870                 875                 880 


Phe Leu Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala 
                885                 890                 895     


Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro 
            900                 905                 910         


Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp 
        915                 920                 925             


Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe Gln 
    930                 935                 940                 


Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg 
945                 950                 955                 960 


Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys Lys 
                965                 970                 975     


Lys His Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr Pro 
            980                 985                 990         


Cys Thr Tyr Phe Tyr Gly Pro Thr  Pro Asp Ile Leu Pro  Val Val Thr 
        995                 1000                 1005             


Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp Val Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp Gly Gly  Thr Phe Lys 
    1025                 1030                 1035             


Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr Tyr Val  Ser Lys Phe 
    1040                 1045                 1050             


Ser Thr  Val Pro Val Ser His  His Glu Cys Ser Phe  Leu Lys Pro 
    1055                 1060                 1065             


Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser Glu Pro  Glu Pro Glu 
    1070                 1075                 1080             


Pro Glu  Pro Glu Pro Gly Gly  Glu Ser Gln Val Arg  Gln Gln Phe 
    1085                 1090                 1095             


Ser Lys  Asp Ile Glu Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1100                 1105                 1110             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Ser Tyr 
    1115                 1120                 1125             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1130                 1135                 1140             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1145                 1150                 1155             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1160                 1165                 1170             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1175                 1180                 1185             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1190                 1195                 1200             


Ala Ile  Lys Cys Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1205                 1210                 1215             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1220                 1225                 1230             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1235                 1240                 1245             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1250                 1255                 1260             


<210>  230
<211>  1255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  230

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Leu Ala Tyr 
865                 870                 875                 880 


Phe Leu Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala 
                885                 890                 895     


Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro 
            900                 905                 910         


Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp 
        915                 920                 925             


Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe Gln 
    930                 935                 940                 


Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg 
945                 950                 955                 960 


Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys Lys 
                965                 970                 975     


Lys His Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr Pro 
            980                 985                 990         


Cys Thr Tyr Phe Tyr Gly Pro Thr  Pro Asp Ile Leu Pro  Val Val Thr 
        995                 1000                 1005             


Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp Val Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp Gly Gly  Thr Phe Lys 
    1025                 1030                 1035             


Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr Tyr Val  Ser Lys Phe 
    1040                 1045                 1050             


Ser Thr  Val Pro Val Ser His  His Glu Cys Ser Phe  Leu Lys Pro 
    1055                 1060                 1065             


Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser Gly Gly  Ser Gly Glu 
    1070                 1075                 1080             


Ser Gln  Val Arg Gln Gln Phe  Ser Lys Asp Ile Glu  Lys Leu Leu 
    1085                 1090                 1095             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1100                 1105                 1110             


Ser Met  Ser Ser Trp Ser Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1115                 1120                 1125             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1130                 1135                 1140             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1145                 1150                 1155             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1160                 1165                 1170             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1175                 1180                 1185             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Cys Lys  Asp His Ala 
    1190                 1195                 1200             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1205                 1210                 1215             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1220                 1225                 1230             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1235                 1240                 1245             


Ile Ala  Lys Ser Arg Lys Ser  
    1250                 1255 


<210>  231
<211>  1329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  231

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Asn Trp 
            20                  25                  30          


Ala Tyr Pro Cys Cys His Val Thr Gln Leu Arg Ala Gln His Leu Leu 
        35                  40                  45              


Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu Val Ser Asn Gln Thr Cys 
    50                  55                  60                  


Asp Ala Phe Ser Leu Ala Ser Leu Asn Ser Pro Lys Gln Gly Ser Asn 
65                  70                  75                  80  


Gln Leu Val Ile Ser Arg Cys Ala Asn Gly Leu Asn Val Val Ser Phe 
                85                  90                  95      


Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser Ala Leu Thr Gly His Leu 
            100                 105                 110         


Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu Tyr Gly Ser Phe Ser Val 
        115                 120                 125             


Glu Asp Leu Phe Gly Ala Gln Leu Asn Arg Tyr Ala Trp His Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Ala Ser Ser 
                165                 170                 175     


Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly Ala 
            180                 185                 190         


Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His Ala 
        195                 200                 205             


Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Leu Ala Lys Val Pro Gly 
    210                 215                 220                 


Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp Leu 
225                 230                 235                 240 


Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly Thr 
                245                 250                 255     


Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser Glu 
            260                 265                 270         


Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile Ser 
        275                 280                 285             


Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys Gln 
    290                 295                 300                 


Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His Ser 
305                 310                 315                 320 


Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu Ser 
                325                 330                 335     


Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys Phe 
            340                 345                 350         


Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His Val 
        355                 360                 365             


Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg Gly 
    370                 375                 380                 


Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Glu Tyr Ser 
385                 390                 395                 400 


Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn Tyr 
                405                 410                 415     


Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met Thr 
            420                 425                 430         


Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu Glu 
        435                 440                 445             


Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Glu Thr Glu Thr Leu Thr 
    450                 455                 460                 


Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala Val 
465                 470                 475                 480 


Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys Ser 
                485                 490                 495     


Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr Gly 
            500                 505                 510         


Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala Ala 
        515                 520                 525             


Ile Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr Thr 
    530                 535                 540                 


Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro Lys 
545                 550                 555                 560 


Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu Leu 
                565                 570                 575     


Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val Met 
            580                 585                 590         


Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu Arg 
        595                 600                 605             


Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu Leu 
    610                 615                 620                 


Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg Gly 
625                 630                 635                 640 


Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu Ser 
                645                 650                 655     


Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Ile Ala Pro Gln 
            660                 665                 670         


Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Gln Ala Val Asp Gly Phe 
        675                 680                 685             


Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His Leu 
    690                 695                 700                 


Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile Ile 
705                 710                 715                 720 


Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val Arg 
                725                 730                 735     


Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser Leu 
            740                 745                 750         


Phe Leu Ser Pro Val Ile Leu Asn Lys Cys Ser Gln Gly Ala Val Ala 
        755                 760                 765             


Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr Gln 
    770                 775                 780                 


Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu Lys 
785                 790                 795                 800 


Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln Asn 
                805                 810                 815     


Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val His 
            820                 825                 830         


Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly Leu 
        835                 840                 845             


Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly 
    850                 855                 860                 


Ala Ser Ala Ser Gly Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser 
865                 870                 875                 880 


Ser Ala Ser Ser Gly Ala Ile Thr Trp Val Pro Lys Pro Asn Val Glu 
                885                 890                 895     


Val Trp Pro Val Asp Pro Pro Pro Pro Val Asn Phe Asn Lys Thr Ala 
            900                 905                 910         


Glu Gln Glu Tyr Gly Asp Lys Glu Val Lys Leu Pro His Trp Thr Pro 
        915                 920                 925             


Thr Leu His Thr Phe Gln Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys 
    930                 935                 940                 


Thr Tyr Cys Asn Thr Arg Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys 
945                 950                 955                 960 


Phe Tyr Phe Thr Lys Lys Lys His Thr Trp Gln Gly Cys Phe Gln Ala 
                965                 970                 975     


Cys Ala Glu Leu Tyr Pro Cys Thr Tyr Phe Tyr Gly Pro Thr Pro Asp 
            980                 985                 990         


Ile Leu Pro Val Val Thr Arg Ser  Leu Gln Ala Ile Glu  Ser Leu Trp 
        995                 1000                 1005             


Val Gly  Val Tyr Arg Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp 
    1010                 1015                 1020             


Gly Gly  Thr Phe Lys Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr 
    1025                 1030                 1035             


Tyr Val  Ser Lys Phe Ser Thr  Val Pro Val Ser His  His Glu Cys 
    1040                 1045                 1050             


Ser Phe  Leu Lys Pro Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser 
    1055                 1060                 1065             


Gly Gly  Ser Gly Ser Ala Ser  Ser Gly Ala Ser Ala  Ser Gly Ser 
    1070                 1075                 1080             


Ser Gly  Ser Gly Ser Gly Ser  Gly Ser Ser Ser Ala  Ser Ser Gly 
    1085                 1090                 1095             


Ala Ser  Ser Gly Gly Ala Ser  Gly Gly Ser Gly Gly  Ser Gly Gly 
    1100                 1105                 1110             


Gly Ser  Gly Ser Ala Ser Ser  Gly Ala Ser Ala Ser  Gly Ser Ser 
    1115                 1120                 1125             


Gly Ser  Gly Ser Gly Ser Gly  Ser Ser Ser Ala Ser  Ser Gly Ala 
    1130                 1135                 1140             


Ser Ser  Gly Gly Ala Ser Gly  Gly Ser Gly Gly Ser  Gly Glu Ser 
    1145                 1150                 1155             


Gln Val  Arg Ser Gln Phe Ser  Lys Asp Ile Glu Lys  Leu Leu Asn 
    1160                 1165                 1170             


Glu Gln  Val Asn Lys Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser 
    1175                 1180                 1185             


Met Ser  Ser Trp Ser Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu 
    1190                 1195                 1200             


Phe Leu  Phe Asp His Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys 
    1205                 1210                 1215             


Leu Ile  Ile Phe Leu Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr 
    1220                 1225                 1230             


Ser Ile  Ser Ala Pro Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile 
    1235                 1240                 1245             


Phe Gln  Lys Ala Tyr Glu His  Glu Gln His Ile Ser  Glu Ser Ile 
    1250                 1255                 1260             


Asn Gln  Ile Val Asp His Ala  Ile Lys Cys Lys Asp  His Ala Thr 
    1265                 1270                 1275             


Phe Asn  Phe Leu Gln Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu 
    1280                 1285                 1290             


Val Leu  Phe Lys Asp Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Gln 
    1295                 1300                 1305             


Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile 
    1310                 1315                 1320             


Ala Lys  Ser Arg Lys Ser 
    1325                 


<210>  232
<211>  1066
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  232

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Glu 
        835                 840                 845             


Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu 
    850                 855                 860                 


Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu 
865                 870                 875                 880 


Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Ser Gln 
                885                 890                 895     


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
            900                 905                 910         


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
        915                 920                 925             


Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
    930                 935                 940                 


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
945                 950                 955                 960 


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
                965                 970                 975     


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
            980                 985                 990         


Glu Gln His Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
        995                 1000                 1005             


Lys Cys  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1010                 1015                 1020             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1025                 1030                 1035             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1040                 1045                 1050             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser 
    1055                 1060                 1065     


<210>  233
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  233

Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser 
1               5                   10                  15      


Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Ala Ser Ser Gly 
            20                  25                  30          


Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
        35                  40                  45      


<210>  234
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  234

Ser Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly 
1               5                   10                  15      


Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly 
            20                  25                  30          


<210>  235
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  235

Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser 
            20                  25                  30          


Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Ser Gly 
        35                  40                  45              


Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala 
65                  70                  75                  80  


Ser Gly Gly Ser Gly Gly Ser Gly 
                85              


<210>  236
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  236

Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser 
            20                  25                  30          


Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
        35                  40                  


<210>  237
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  237

Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Gly Gly 
1               5                   10          


<210>  238
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  238

Ser Gly Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
1               5                   10                  15      


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
            20                  25                  30          


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
        35                  40                  45              


<210>  239
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  239

Leu Ala Tyr Phe Leu Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala 
1               5                   10                  15      


Ala Ala Ala Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro 
            20                  25                  30          


Val Asp Pro Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu 
        35                  40                  45              


Tyr Gly Asp Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His 
    50                  55                  60                  


Thr Phe Gln Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys 
65                  70                  75                  80  


Asn Thr Arg Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe 
                85                  90                  95      


Thr Lys Lys Lys His Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu 
            100                 105                 110         


Leu Tyr Pro Cys Thr Tyr Phe Tyr Gly Pro Thr Pro Asp Ile Leu Pro 
        115                 120                 125             


Val Val Thr Arg Asn Leu Asn Ala Ile Glu Ser Leu Trp Val Gly Val 
    130                 135                 140                 


Tyr Arg Val Gly Glu Gly Asn Trp Thr Ser Leu Asp Gly Gly Thr Phe 
145                 150                 155                 160 


Lys Val Tyr Gln Ile Phe Gly Ser His Cys Thr Tyr Val Ser Lys Phe 
                165                 170                 175     


Ser Thr Val Pro Val Ser His His Glu Cys Ser Phe Leu Lys Pro Cys 
            180                 185                 190         


Leu Cys Val Ser Gln Arg Ser Asn Ser 
        195                 200     


<210>  240
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  240

Ala Ile Thr Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp 
1               5                   10                  15      


Pro Pro Pro Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly 
            20                  25                  30          


Asp Lys Glu Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe 
        35                  40                  45              


Gln Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr 
    50                  55                  60                  


Arg Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys 
65                  70                  75                  80  


Lys Lys His Thr Trp Gln Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr 
                85                  90                  95      


Pro Cys Thr Tyr Phe Tyr Gly Pro Thr Pro Asp Ile Leu Pro Val Val 
            100                 105                 110         


Thr Arg Ser Leu Gln Ala Ile Glu Ser Leu Trp Val Gly Val Tyr Arg 
        115                 120                 125             


Val Gly Glu Gly Asn Trp Thr Ser Leu Asp Gly Gly Thr Phe Lys Val 
    130                 135                 140                 


Tyr Gln Ile Phe Gly Ser His Cys Thr Tyr Val Ser Lys Phe Ser Thr 
145                 150                 155                 160 


Val Pro Val Ser His His Glu Cys Ser Phe Leu Lys Pro Cys Leu Cys 
                165                 170                 175     


Val Ser Gln Arg Ser Asn Ser 
            180             


<210>  241
<211>  1329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  241

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Asn Trp 
            20                  25                  30          


Ala Tyr Pro Cys Cys His Val Thr Gln Leu Arg Ala Gln His Leu Leu 
        35                  40                  45              


Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu Val Ser Asn Gln Thr Cys 
    50                  55                  60                  


Asp Ala Phe Ser Leu Ala Ser Leu Asn Ser Pro Lys Gln Gly Ser Asn 
65                  70                  75                  80  


Gln Leu Val Ile Ser Arg Cys Ala Asn Gly Leu Asn Val Val Ser Phe 
                85                  90                  95      


Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser Ala Leu Thr Gly His Leu 
            100                 105                 110         


Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu Tyr Gly Ser Phe Ser Val 
        115                 120                 125             


Glu Asp Leu Phe Gly Ala Gln Leu Asn Arg Tyr Ala Trp His Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Ala Ser Ser 
                165                 170                 175     


Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly Ala 
            180                 185                 190         


Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His Ala 
        195                 200                 205             


Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Leu Ala Lys Val Pro Gly 
    210                 215                 220                 


Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp Leu 
225                 230                 235                 240 


Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly Thr 
                245                 250                 255     


Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser Glu 
            260                 265                 270         


Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile Ser 
        275                 280                 285             


Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys Gln 
    290                 295                 300                 


Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His Ser 
305                 310                 315                 320 


Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu Ser 
                325                 330                 335     


Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys Phe 
            340                 345                 350         


Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His Val 
        355                 360                 365             


Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg Gly 
    370                 375                 380                 


Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Glu Tyr Ser 
385                 390                 395                 400 


Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn Tyr 
                405                 410                 415     


Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met Thr 
            420                 425                 430         


Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu Glu 
        435                 440                 445             


Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Glu Thr Glu Thr Leu Thr 
    450                 455                 460                 


Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala Val 
465                 470                 475                 480 


Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys Ser 
                485                 490                 495     


Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr Gly 
            500                 505                 510         


Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala Ala 
        515                 520                 525             


Ile Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr Thr 
    530                 535                 540                 


Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro Lys 
545                 550                 555                 560 


Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu Leu 
                565                 570                 575     


Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val Met 
            580                 585                 590         


Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu Arg 
        595                 600                 605             


Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu Leu 
    610                 615                 620                 


Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg Gly 
625                 630                 635                 640 


Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu Ser 
                645                 650                 655     


Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Ile Ala Pro Gln 
            660                 665                 670         


Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Gln Ala Val Asp Gly Phe 
        675                 680                 685             


Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His Leu 
    690                 695                 700                 


Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile Ile 
705                 710                 715                 720 


Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val Arg 
                725                 730                 735     


Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser Leu 
            740                 745                 750         


Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala Val Ala 
        755                 760                 765             


Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr Gln 
    770                 775                 780                 


Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu Lys 
785                 790                 795                 800 


Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln Asn 
                805                 810                 815     


Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val His 
            820                 825                 830         


Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly Leu 
        835                 840                 845             


Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly 
    850                 855                 860                 


Ala Ser Ala Ser Gly Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser 
865                 870                 875                 880 


Ser Ala Ser Ser Gly Ala Ile Thr Trp Val Pro Lys Pro Asn Val Glu 
                885                 890                 895     


Val Trp Pro Val Asp Pro Pro Pro Pro Val Asn Phe Asn Lys Thr Ala 
            900                 905                 910         


Glu Gln Glu Tyr Gly Asp Lys Glu Val Lys Leu Pro His Trp Thr Pro 
        915                 920                 925             


Thr Leu His Thr Phe Gln Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys 
    930                 935                 940                 


Thr Tyr Cys Asn Thr Arg Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys 
945                 950                 955                 960 


Phe Tyr Phe Thr Lys Lys Lys His Thr Trp Gln Gly Cys Phe Gln Ala 
                965                 970                 975     


Cys Ala Glu Leu Tyr Pro Cys Thr Tyr Phe Tyr Gly Pro Thr Pro Asp 
            980                 985                 990         


Ile Leu Pro Val Val Thr Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp 
        995                 1000                 1005             


Val Gly  Val Tyr Arg Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp 
    1010                 1015                 1020             


Gly Gly  Thr Phe Lys Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr 
    1025                 1030                 1035             


Tyr Val  Ser Lys Phe Ser Thr  Val Pro Val Ser His  His Glu Cys 
    1040                 1045                 1050             


Ser Phe  Leu Lys Pro Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser 
    1055                 1060                 1065             


Gly Gly  Ser Gly Ser Ala Ser  Ser Gly Ala Ser Ala  Ser Gly Ser 
    1070                 1075                 1080             


Ser Gly  Ser Gly Ser Gly Ser  Gly Ser Ser Ser Ala  Ser Ser Gly 
    1085                 1090                 1095             


Ala Ser  Ser Gly Gly Ala Ser  Gly Gly Ser Gly Gly  Ser Gly Gly 
    1100                 1105                 1110             


Gly Ser  Gly Ser Ala Ser Ser  Gly Ala Ser Ala Ser  Gly Ser Ser 
    1115                 1120                 1125             


Gly Ser  Gly Ser Gly Ser Gly  Ser Ser Ser Ala Ser  Ser Gly Ala 
    1130                 1135                 1140             


Ser Ser  Gly Gly Ala Ser Gly  Gly Ser Gly Gly Ser  Gly Glu Ser 
    1145                 1150                 1155             


Gln Val  Arg Ser Gln Phe Ser  Lys Asp Ile Glu Lys  Leu Leu Asn 
    1160                 1165                 1170             


Glu Gln  Val Asn Lys Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser 
    1175                 1180                 1185             


Met Ser  Ser Trp Ser Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu 
    1190                 1195                 1200             


Phe Leu  Phe Asp His Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys 
    1205                 1210                 1215             


Leu Ile  Ile Phe Leu Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr 
    1220                 1225                 1230             


Ser Ile  Ser Ala Pro Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile 
    1235                 1240                 1245             


Phe Gln  Lys Ala Tyr Glu His  Glu Gln His Ile Ser  Glu Ser Ile 
    1250                 1255                 1260             


Asn Gln  Ile Val Asp His Ala  Ile Lys Cys Lys Asp  His Ala Thr 
    1265                 1270                 1275             


Phe Asn  Phe Leu Gln Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu 
    1280                 1285                 1290             


Val Leu  Phe Lys Asp Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Gln 
    1295                 1300                 1305             


Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile 
    1310                 1315                 1320             


Ala Lys  Ser Arg Lys Ser 
    1325                 


<210>  242
<211>  1329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  242

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Asn Trp 
            20                  25                  30          


Ala Tyr Pro Cys Cys His Val Thr Gln Leu Arg Ala Gln His Leu Leu 
        35                  40                  45              


Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu Val Ser Asn Gln Thr Cys 
    50                  55                  60                  


Asp Ala Phe Ser Leu Ala Ser Leu Asn Ser Pro Lys Gln Gly Ser Asn 
65                  70                  75                  80  


Gln Leu Val Ile Ser Arg Cys Ala Asn Gly Leu Asn Val Val Ser Phe 
                85                  90                  95      


Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser Ala Leu Thr Gly His Leu 
            100                 105                 110         


Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu Tyr Gly Ser Phe Ser Val 
        115                 120                 125             


Glu Asp Leu Phe Gly Ala Gln Leu Asn Arg Tyr Ala Trp His Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Ala Ser Ser 
                165                 170                 175     


Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly Ala 
            180                 185                 190         


Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His Ala 
        195                 200                 205             


Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Leu Ala Lys Val Pro Gly 
    210                 215                 220                 


Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp Leu 
225                 230                 235                 240 


Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly Thr 
                245                 250                 255     


Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser Glu 
            260                 265                 270         


Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile Ser 
        275                 280                 285             


Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys Gln 
    290                 295                 300                 


Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His Ser 
305                 310                 315                 320 


Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu Ser 
                325                 330                 335     


Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys Phe 
            340                 345                 350         


Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His Val 
        355                 360                 365             


Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg Gly 
    370                 375                 380                 


Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Glu Tyr Ser 
385                 390                 395                 400 


Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn Tyr 
                405                 410                 415     


Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met Thr 
            420                 425                 430         


Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu Glu 
        435                 440                 445             


Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Glu Thr Glu Thr Leu Thr 
    450                 455                 460                 


Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala Val 
465                 470                 475                 480 


Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys Ser 
                485                 490                 495     


Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr Gly 
            500                 505                 510         


Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala Ala 
        515                 520                 525             


Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr Thr 
    530                 535                 540                 


Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro Lys 
545                 550                 555                 560 


Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu Leu 
                565                 570                 575     


Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val Met 
            580                 585                 590         


Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu Arg 
        595                 600                 605             


Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu Leu 
    610                 615                 620                 


Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg Gly 
625                 630                 635                 640 


Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu Ser 
                645                 650                 655     


Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala Pro Gln 
            660                 665                 670         


Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp Gly Phe 
        675                 680                 685             


Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His Leu 
    690                 695                 700                 


Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile Ile 
705                 710                 715                 720 


Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val Arg 
                725                 730                 735     


Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser Leu 
            740                 745                 750         


Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala Val Ala 
        755                 760                 765             


Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr Gln 
    770                 775                 780                 


Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu Lys 
785                 790                 795                 800 


Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln Asn 
                805                 810                 815     


Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val His 
            820                 825                 830         


Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly Leu 
        835                 840                 845             


Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly 
    850                 855                 860                 


Ala Ser Ala Ser Gly Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser 
865                 870                 875                 880 


Ser Ala Ser Ser Gly Ala Ile Thr Trp Val Pro Lys Pro Asn Val Glu 
                885                 890                 895     


Val Trp Pro Val Asp Pro Pro Pro Pro Val Asn Phe Asn Lys Thr Ala 
            900                 905                 910         


Glu Gln Glu Tyr Gly Asp Lys Glu Val Lys Leu Pro His Trp Thr Pro 
        915                 920                 925             


Thr Leu His Thr Phe Gln Val Pro Gln Asn Tyr Thr Lys Ala Asn Cys 
    930                 935                 940                 


Thr Tyr Cys Asn Thr Arg Glu Tyr Thr Phe Ser Tyr Lys Gly Cys Cys 
945                 950                 955                 960 


Phe Tyr Phe Thr Lys Lys Lys His Thr Trp Asn Gly Cys Phe Gln Ala 
                965                 970                 975     


Cys Ala Glu Leu Tyr Pro Cys Thr Tyr Phe Tyr Gly Pro Thr Pro Asp 
            980                 985                 990         


Ile Leu Pro Val Val Thr Arg Asn  Leu Asn Ala Ile Glu  Ser Leu Trp 
        995                 1000                 1005             


Val Gly  Val Tyr Arg Val Gly  Glu Gly Asn Trp Thr  Ser Leu Asp 
    1010                 1015                 1020             


Gly Gly  Thr Phe Lys Val Tyr  Gln Ile Phe Gly Ser  His Cys Thr 
    1025                 1030                 1035             


Tyr Val  Ser Lys Phe Ser Thr  Val Pro Val Ser His  His Glu Cys 
    1040                 1045                 1050             


Ser Phe  Leu Lys Pro Cys Leu  Cys Val Ser Gln Arg  Ser Asn Ser 
    1055                 1060                 1065             


Gly Gly  Ser Gly Ser Ala Ser  Ser Gly Ala Ser Ala  Ser Gly Ser 
    1070                 1075                 1080             


Ser Gly  Ser Gly Ser Gly Ser  Gly Ser Ser Ser Ala  Ser Ser Gly 
    1085                 1090                 1095             


Ala Ser  Ser Gly Gly Ala Ser  Gly Gly Ser Gly Gly  Ser Gly Gly 
    1100                 1105                 1110             


Gly Ser  Gly Ser Ala Ser Ser  Gly Ala Ser Ala Ser  Gly Ser Ser 
    1115                 1120                 1125             


Gly Ser  Gly Ser Gly Ser Gly  Ser Ser Ser Ala Ser  Ser Gly Ala 
    1130                 1135                 1140             


Ser Ser  Gly Gly Ala Ser Gly  Gly Ser Gly Gly Ser  Gly Glu Ser 
    1145                 1150                 1155             


Gln Val  Arg Ser Gln Phe Ser  Lys Asp Ile Glu Lys  Leu Leu Asn 
    1160                 1165                 1170             


Glu Gln  Val Asn Lys Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser 
    1175                 1180                 1185             


Met Ser  Ser Trp Ser Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu 
    1190                 1195                 1200             


Phe Leu  Phe Asp His Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys 
    1205                 1210                 1215             


Leu Ile  Ile Phe Leu Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr 
    1220                 1225                 1230             


Ser Ile  Ser Ala Pro Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile 
    1235                 1240                 1245             


Phe Gln  Lys Ala Tyr Glu His  Glu Gln His Ile Ser  Glu Ser Ile 
    1250                 1255                 1260             


Asn Gln  Ile Val Asp His Ala  Ile Lys Cys Lys Asp  His Ala Thr 
    1265                 1270                 1275             


Phe Asn  Phe Leu Gln Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu 
    1280                 1285                 1290             


Val Leu  Phe Lys Asp Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Gln 
    1295                 1300                 1305             


Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile 
    1310                 1315                 1320             


Ala Lys  Ser Arg Lys Ser 
    1325                 


<210>  243

<400>  243
000

<210>  244

<400>  244
000

<210>  245

<400>  245
000

<210>  246

<400>  246
000

<210>  247

<400>  247
000

<210>  248

<400>  248
000

<210>  249

<400>  249
000

<210>  250

<400>  250
000

<210>  251

<400>  251
000

<210>  252

<400>  252
000

<210>  253

<400>  253
000

<210>  254

<400>  254
000

<210>  255

<400>  255
000

<210>  256

<400>  256
000

<210>  257

<400>  257
000

<210>  258

<400>  258
000

<210>  259

<400>  259
000

<210>  260

<400>  260
000

<210>  261

<400>  261
000

<210>  262

<400>  262
000

<210>  263

<400>  263
000

<210>  264

<400>  264
000

<210>  265

<400>  265
000

<210>  266

<400>  266
000

<210>  267

<400>  267
000

<210>  268

<400>  268
000

<210>  269

<400>  269
000

<210>  270

<400>  270
000

<210>  271

<400>  271
000

<210>  272

<400>  272
000

<210>  273

<400>  273
000

<210>  274

<400>  274
000

<210>  275

<400>  275
000

<210>  276

<400>  276
000

<210>  277

<400>  277
000

<210>  278

<400>  278
000

<210>  279

<400>  279
000

<210>  280

<400>  280
000

<210>  281

<400>  281
000

<210>  282

<400>  282
000

<210>  283

<400>  283
000

<210>  284

<400>  284
000

<210>  285

<400>  285
000

<210>  286

<400>  286
000

<210>  287

<400>  287
000

<210>  288

<400>  288
000

<210>  289

<400>  289
000

<210>  290

<400>  290
000

<210>  291

<400>  291
000

<210>  292

<400>  292
000

<210>  293

<400>  293
000

<210>  294

<400>  294
000

<210>  295

<400>  295
000

<210>  296

<400>  296
000

<210>  297

<400>  297
000

<210>  298

<400>  298
000

<210>  299

<400>  299
000

<210>  300

<400>  300
000

<210>  301
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  301

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Ser Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu 
        515                 520                 525             


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
    530                 535                 540                 


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
545                 550                 555                 560 


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
                565                 570                 575     


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
            580                 585                 590         


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
        595                 600                 605             


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
    610                 615                 620                 


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
625                 630                 635                 640 


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
                645                 650                 655     


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
            660                 665                 670         


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        675                 680                 685 


<210>  302
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  302

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Ser Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser 
    690         


<210>  303
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  303

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Ser Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser 
    690         


<210>  304
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  304

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Ser Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Cys Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser 
    690         


<210>  305
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  305

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Ser Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Cys Met Ser Ser Trp Ser Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser 
    690         


<210>  306
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  306

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Ser Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Cys Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser 
    690         


<210>  307
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  307

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Ser Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Cys Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser 
    690         


<210>  308
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  308

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Ser Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Cys Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser 
    690         


<210>  309
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  309

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Glu Asn Leu Tyr Phe Gln Gly Ser Glu Ser Gln 
        515                 520                 525             


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
    530                 535                 540                 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
545                 550                 555                 560 


Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
                565                 570                 575     


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
            580                 585                 590         


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
        595                 600                 605             


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
    610                 615                 620                 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
625                 630                 635                 640 


Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
                645                 650                 655     


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
            660                 665                 670         


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
        675                 680                 685             


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    690                 695             


<210>  310
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  310

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Glu Asn Leu Tyr Phe Gln Gly Ser Glu Ser Gln 
        515                 520                 525             


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
    530                 535                 540                 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Cys Met Ser Ser 
545                 550                 555                 560 


Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
                565                 570                 575     


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
            580                 585                 590         


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
        595                 600                 605             


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
    610                 615                 620                 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
625                 630                 635                 640 


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
                645                 650                 655     


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
            660                 665                 670         


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
        675                 680                 685             


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    690                 695             


<210>  311
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  311

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Glu Asn Leu Tyr Phe Gln Gly Ser Glu Ser Gln 
        515                 520                 525             


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
    530                 535                 540                 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
545                 550                 555                 560 


Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
                565                 570                 575     


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
            580                 585                 590         


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Cys Ile Ser Ala Pro Glu 
        595                 600                 605             


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
    610                 615                 620                 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
625                 630                 635                 640 


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
                645                 650                 655     


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
            660                 665                 670         


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
        675                 680                 685             


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    690                 695             


<210>  312
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  312

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Glu Asn Leu Tyr Phe Gln Gly Ser Glu Ser Gln 
        515                 520                 525             


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
    530                 535                 540                 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
545                 550                 555                 560 


Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
                565                 570                 575     


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
            580                 585                 590         


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Cys Pro Glu 
        595                 600                 605             


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
    610                 615                 620                 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
625                 630                 635                 640 


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
                645                 650                 655     


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
            660                 665                 670         


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
        675                 680                 685             


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    690                 695             


<210>  313
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  313

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Glu Asn Leu Tyr Phe Gln Gly Ser Glu Ser Gln 
        515                 520                 525             


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
    530                 535                 540                 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
545                 550                 555                 560 


Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
                565                 570                 575     


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
            580                 585                 590         


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
        595                 600                 605             


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
    610                 615                 620                 


Glu Gln His Ile Ser Glu Cys Ile Asn Asn Ile Val Asp His Ala Ile 
625                 630                 635                 640 


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
                645                 650                 655     


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
            660                 665                 670         


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
        675                 680                 685             


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    690                 695             


<210>  314
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  314

Met Glu Ala Arg Leu Leu Val Leu Leu Cys Ala Phe Ala Ala Thr Asn 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Leu Leu Leu Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Asn Ser Glu Asn Gly Thr Cys Phe Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Lys Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Glu 
    130                 135                 140                 


Thr Thr Lys Gly Val Thr Ala Ala Cys Ser Tyr Ala Gly Ala Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Gly Ser Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Pro Thr Gly Thr Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Ser Val Gly Ser Ser Lys Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Asn Arg Gly Ser Gly Ser Gly Ile Ile Thr Ser Asp Ala Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Lys Cys Gln Thr Pro His Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn 
                405                 410                 415     


Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Arg Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Ala Cys Met Glu Ser Val 
                485                 490                 495     


Arg Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Ser Gly Gly Glu Ser Gln Val Arg Gln Gln 
        515                 520                 525             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    530                 535                 540                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr 
545                 550                 555                 560 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                565                 570                 575     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            580                 585                 590         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        595                 600                 605             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    610                 615                 620                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp 
625                 630                 635                 640 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                645                 650                 655     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            660                 665                 670         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        675                 680                 685             


Ala Lys Ser Arg Lys Ser 
    690                 


<210>  315
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  315

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Phe Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Ser Gly Gly Glu Ser Gln Val Arg Gln Gln 
        515                 520                 525             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    530                 535                 540                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr 
545                 550                 555                 560 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                565                 570                 575     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            580                 585                 590         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        595                 600                 605             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    610                 615                 620                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp 
625                 630                 635                 640 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                645                 650                 655     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            660                 665                 670         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        675                 680                 685             


Ala Lys Ser Arg Lys Ser 
    690                 


<210>  316
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  316

Met Lys Ala Arg Leu Leu Ile Leu Leu Cys Ala Leu Ser Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Leu Ser Asn Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Ala Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Phe Pro Gly Asp Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Lys His Asn 
    130                 135                 140                 


Ile Thr Arg Gly Val Thr Val Ala Cys Ser His Ala Lys Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Leu Trp Leu Thr Glu Ala Asn Gly Leu Tyr Pro 
                165                 170                 175     


Ser Leu Ser Lys Ser Tyr Val Asn Asp Arg Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Asn Ile Glu Asp Gln Arg Thr Leu 
        195                 200                 205             


Tyr Arg Lys Glu Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Pro Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Pro Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
        275                 280                 285             


Met Asp Glu Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Asn Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Ala Lys Ile Asp Ser Gly Gly Glu Ser Gln Val Arg Gln Gln 
        515                 520                 525             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    530                 535                 540                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr 
545                 550                 555                 560 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                565                 570                 575     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            580                 585                 590         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        595                 600                 605             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    610                 615                 620                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp 
625                 630                 635                 640 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                645                 650                 655     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            660                 665                 670         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        675                 680                 685             


Ala Lys Ser Arg Lys Ser 
    690                 


<210>  317
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  317

Met Lys Ala Lys Leu Leu Ile Leu Leu Cys Ala Leu Thr Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Leu Ser Lys Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Ala Glu Thr Pro Asn Ser Glu Asn Gly Ala Cys Phe Pro Gly Asp Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Arg Ser Trp Pro Lys His Asn 
    130                 135                 140                 


Ile Thr Arg Gly Val Thr Ala Ala Cys Ser His Ala Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Leu Trp Leu Thr Glu Thr Asp Gly Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Asn Ile Glu Asp Gln Lys Thr Leu 
        195                 200                 205             


Tyr Arg Lys Glu Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Ala Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Asp Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
        275                 280                 285             


Met Asp Glu Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Asn Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Ser Gly Gly Glu Ser Gln Val Arg Gln Gln 
        515                 520                 525             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    530                 535                 540                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr 
545                 550                 555                 560 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                565                 570                 575     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            580                 585                 590         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        595                 600                 605             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    610                 615                 620                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp 
625                 630                 635                 640 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                645                 650                 655     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            660                 665                 670         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        675                 680                 685             


Ala Lys Ser Arg Lys Ser 
    690                 


<210>  318
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  318

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Ala Leu Ser Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Ser Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Phe Ser Lys Lys Ser Trp Ser Tyr Ile 
                85                  90                  95      


Ala Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Arg Ser Trp Pro Lys His Asn 
    130                 135                 140                 


Val Thr Arg Gly Val Thr Ala Ser Cys Ser His Lys Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Ser Tyr Pro 
                165                 170                 175     


Asn Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Asn Ile Glu Asp Gln Lys Thr Ile 
        195                 200                 205             


Tyr Arg Lys Glu Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Ala Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
        275                 280                 285             


Met Asp Glu Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Ser Gly Gly Glu Ser Gln Val Arg Gln Gln 
        515                 520                 525             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    530                 535                 540                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr 
545                 550                 555                 560 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                565                 570                 575     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            580                 585                 590         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        595                 600                 605             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    610                 615                 620                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp 
625                 630                 635                 640 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                645                 650                 655     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            660                 665                 670         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        675                 680                 685             


Ala Lys Ser Arg Lys Ser 
    690                 


<210>  319
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  319

Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly Asp 
1               5                   10                  15      


Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Lys Val Asp 
            20                  25                  30          


Thr Ile Leu Glu Arg Asn Val Thr Val Thr His Ala Lys Asp Ile Leu 
        35                  40                  45              


Glu Lys Thr His Asn Gly Lys Leu Cys Lys Leu Asn Gly Ile Pro Pro 
    50                  55                  60                  


Leu Glu Leu Gly Asp Cys Ser Ile Ala Gly Trp Leu Leu Gly Asn Pro 
65                  70                  75                  80  


Glu Cys Asp Arg Leu Leu Ser Val Pro Glu Trp Ser Tyr Ile Met Glu 
                85                  90                  95      


Lys Glu Asn Pro Arg Asp Gly Leu Cys Phe Pro Gly Ser Phe Asn Asp 
            100                 105                 110         


Tyr Glu Glu Leu Lys His Leu Leu Ser Ser Val Lys His Phe Glu Lys 
        115                 120                 125             


Val Lys Ile Leu Pro Lys Asp Arg Trp Thr Gln His Thr Thr Thr Gly 
    130                 135                 140                 


Gly Ser Arg Ala Cys Ala Val Ser Gly Asn Pro Ser Phe Phe Arg Asn 
145                 150                 155                 160 


Met Val Trp Leu Thr Lys Lys Glu Ser Asn Tyr Pro Val Ala Lys Gly 
                165                 170                 175     


Ser Tyr Asn Asn Thr Ser Gly Glu Gln Met Leu Ile Ile Trp Gly Val 
            180                 185                 190         


His His Pro Asn Asp Glu Thr Glu Gln Arg Thr Leu Tyr Gln Asn Val 
        195                 200                 205             


Gly Thr Tyr Val Ser Val Gly Thr Ser Thr Leu Asn Lys Arg Ser Thr 
    210                 215                 220                 


Pro Asp Ile Ala Thr Arg Pro Lys Val Asn Gly Leu Gly Ser Arg Met 
225                 230                 235                 240 


Glu Phe Ser Trp Thr Leu Leu Asp Met Trp Asp Thr Ile Asn Phe Glu 
                245                 250                 255     


Ser Thr Gly Asn Leu Ile Ala Pro Glu Tyr Gly Phe Lys Ile Ser Lys 
            260                 265                 270         


Arg Gly Ser Ser Gly Ile Met Lys Thr Glu Gly Thr Leu Glu Asn Cys 
        275                 280                 285             


Glu Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Thr Thr Leu Pro 
    290                 295                 300                 


Phe His Asn Val His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val 
305                 310                 315                 320 


Lys Ser Glu Lys Leu Val Leu Ala Thr Gly Leu Arg Asn Val Pro Gln 
                325                 330                 335     


Ile Glu Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
            340                 345                 350         


Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn 
        355                 360                 365             


Asp Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala 
    370                 375                 380                 


Phe Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn 
385                 390                 395                 400 


Thr Gln Phe Glu Ala Val Gly Lys Glu Phe Ser Asn Leu Glu Arg Arg 
                405                 410                 415     


Leu Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp 
            420                 425                 430         


Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu 
        435                 440                 445             


Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Met 
    450                 455                 460                 


Gln Leu Arg Asp Asn Val Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe 
465                 470                 475                 480 


Tyr His Lys Cys Asp Asp Glu Cys Met Asn Ser Val Lys Asn Gly Thr 
                485                 490                 495     


Tyr Asp Tyr Pro Lys Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu 
            500                 505                 510         


Ile Lys Ser Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp 
        515                 520                 525             


Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser 
    530                 535                 540                 


Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp 
545                 550                 555                 560 


Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His 
                565                 570                 575     


Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln 
            580                 585                 590         


Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln 
        595                 600                 605             


Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile 
    610                 615                 620                 


Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp His Ala Thr Phe 
625                 630                 635                 640 


Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu 
                645                 650                 655     


Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His 
            660                 665                 670         


Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg 
        675                 680                 685             


Lys Ser 
    690 


<210>  320
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  320

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Thr Asn Asp Leu Cys Phe Pro Gly Ser Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Leu Gly Ser Pro Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Lys Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Ile Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu 
                405                 410                 415     


Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
            420                 425                 430         


Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 
    450                 455                 460                 


Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Ile Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asn Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg 
            500                 505                 510         


Glu Glu Ile Ser Ser Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser 
    690         


<210>  321
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  321

Met Lys Ala Lys Leu Leu Ile Leu Leu Cys Ala Leu Ser Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Lys 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Asn Ile Ala Gly Trp Val Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Leu Ser Asn Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Ala Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Phe Pro Gly Asp Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Arg Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Thr Arg Gly Val Thr Ala Ala Cys Pro His Ala Arg Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Lys Asn Leu Val Trp Leu Thr Glu Ala Asn Gly Ser Tyr Pro Asn 
                165                 170                 175     


Leu Ser Arg Ser Tyr Val Asn Asn Gln Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Ser Asn Ile Glu Glu Gln Arg Ala Leu Tyr 
        195                 200                 205             


Arg Lys Asp Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Ser 
225                 230                 235                 240 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Pro Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Leu 
        275                 280                 285             


Asp Glu Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Val Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Met Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Met 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Asn Gln Leu Arg Asn Asn Ala Lys Glu Leu Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Ser Gly Gly Glu Ser Gln Val Arg Gln Gln Phe 
        515                 520                 525             


Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met 
    530                 535                 540                 


Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His 
545                 550                 555                 560 


Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu 
                565                 570                 575     


Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val 
            580                 585                 590         


Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly 
        595                 600                 605             


Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser 
    610                 615                 620                 


Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp His 
625                 630                 635                 640 


Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu 
                645                 650                 655     


Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn 
            660                 665                 670         


Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala 
        675                 680                 685             


Lys Ser Arg Lys Ser 
    690             


<210>  322
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  322

Met Lys Thr Thr Ile Ile Leu Ile Leu Leu Thr His Trp Ala Tyr Ser 
1               5                   10                  15      


Gln Asn Pro Ile Ser Gly Asn Asn Thr Ala Thr Leu Cys Leu Gly His 
            20                  25                  30          


His Ala Val Ala Asn Gly Thr Leu Val Lys Thr Ile Ser Asp Asp Gln 
        35                  40                  45              


Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ile Ser Met Gly 
    50                  55                  60                  


Lys Ile Cys Asn Asn Ser Tyr Arg Ile Leu Asp Gly Arg Asn Cys Thr 
65                  70                  75                  80  


Leu Ile Asp Ala Met Leu Gly Asp Pro His Cys Asp Ala Phe Gln Tyr 
                85                  90                  95      


Glu Asn Trp Asp Leu Phe Ile Glu Arg Ser Ser Ala Phe Ser Asn Cys 
            100                 105                 110         


Phe Pro Tyr Asp Ile Pro Asp Tyr Ala Ser Leu Arg Ser Ile Val Ala 
        115                 120                 125             


Ser Ser Gly Thr Leu Glu Phe Thr Ala Glu Gly Phe Thr Trp Thr Gly 
    130                 135                 140                 


Val Thr Gln Asn Gly Arg Ser Gly Ala Cys Lys Arg Gly Ser Ala Asp 
145                 150                 155                 160 


Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Ser Gly Ser Ser Tyr 
                165                 170                 175     


Pro Thr Leu Asn Val Thr Met Pro Asn Asn Lys Asn Phe Asp Lys Leu 
            180                 185                 190         


Tyr Ile Trp Gly Ile His His Pro Ser Ser Asn Gln Glu Gln Thr Lys 
        195                 200                 205             


Leu Tyr Ile Gln Glu Ser Gly Arg Val Thr Val Ser Thr Lys Arg Ser 
    210                 215                 220                 


Gln Gln Thr Ile Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg Gly 
225                 230                 235                 240 


Gln Ser Gly Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly Asp 
                245                 250                 255     


Ile Leu Met Ile Asn Ser Asn Gly Asn Leu Val Ala Pro Arg Gly Tyr 
            260                 265                 270         


Phe Lys Leu Lys Thr Gly Lys Ser Ser Val Met Arg Ser Asp Val Pro 
        275                 280                 285             


Ile Asp Ile Cys Val Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile Ser 
    290                 295                 300                 


Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Val Thr Tyr Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Ile Arg Gln Asn Thr Leu Lys Leu Ala Thr Gly Met Arg 
                325                 330                 335     


Asn Val Pro Glu Lys Gln Ile Arg Gly Ile Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly Phe 
        355                 360                 365             


Arg Tyr Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Val Ile 
385                 390                 395                 400 


Glu Arg Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser Glu 
                405                 410                 415     


Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr Lys 
            420                 425                 430         


Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn 
        435                 440                 445             


Gln His Thr Ile Asp Leu Thr Asp Ala Glu Met Asn Lys Leu Phe Glu 
    450                 455                 460                 


Lys Thr Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Gly Gly 
465                 470                 475                 480 


Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser Ile 
                485                 490                 495     


Arg Asn Gly Thr Tyr Asp His Tyr Ile Tyr Arg Asp Glu Ala Leu Asn 
            500                 505                 510         


Asn Arg Phe Lys Ile Asp Ser Gly Gly Glu Ser Gln Val Arg Gln Gln 
        515                 520                 525             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    530                 535                 540                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr 
545                 550                 555                 560 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                565                 570                 575     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            580                 585                 590         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        595                 600                 605             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    610                 615                 620                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp 
625                 630                 635                 640 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                645                 650                 655     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            660                 665                 670         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        675                 680                 685             


Ala Lys Ser Arg Lys Ser 
    690                 


<210>  323
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  323

Met Lys Thr Thr Ile Ile Phe Ile Phe Ile Leu Leu Thr His Trp Ala 
1               5                   10                  15      


Tyr Ser Gln Asn Pro Ile Ser Asp Asn Asn Thr Ala Thr Leu Cys Leu 
            20                  25                  30          


Gly His His Ala Val Ala Asn Gly Thr Leu Val Lys Thr Ile Ser Asp 
        35                  40                  45              


Asp Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ile Ser 
    50                  55                  60                  


Met Gly Lys Ile Cys Asn Asn Ser Tyr Arg Ile Leu Asp Gly Arg Asn 
65                  70                  75                  80  


Cys Thr Leu Ile Asp Ala Met Leu Gly Asp Pro His Cys Asp Val Phe 
                85                  90                  95      


Gln Tyr Glu Asn Trp Asp Leu Phe Ile Glu Arg Ser Ser Ala Phe Ser 
            100                 105                 110         


Asn Cys Phe Pro Tyr Asp Ile Pro Asp Tyr Ala Ser Leu Arg Ser Ile 
        115                 120                 125             


Val Ala Ser Ser Gly Thr Leu Glu Phe Thr Ala Glu Gly Phe Thr Trp 
    130                 135                 140                 


Thr Gly Val Thr Gln Asn Gly Arg Ser Gly Ala Cys Lys Arg Gly Ser 
145                 150                 155                 160 


Ala Asp Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Ser Gly Asn 
                165                 170                 175     


Ser Tyr Pro Thr Leu Asn Val Thr Met Pro Asn Asn Lys Asn Phe Asp 
            180                 185                 190         


Lys Leu Tyr Ile Trp Gly Ile His His Pro Ser Ser Asn Gln Glu Gln 
        195                 200                 205             


Thr Lys Leu Tyr Ile Gln Glu Ser Gly Arg Val Thr Val Ser Thr Lys 
    210                 215                 220                 


Arg Ser Gln Gln Thr Met Ile Pro Asn Ile Gly Ser Arg Pro Trp Val 
225                 230                 235                 240 


Arg Gly Gln Ser Gly Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro 
                245                 250                 255     


Gly Asp Ile Leu Met Ile Asn Ser Asn Gly Asn Leu Val Ala Pro Arg 
            260                 265                 270         


Gly Tyr Phe Lys Leu Lys Thr Gly Lys Ser Ser Val Met Arg Ser Asp 
        275                 280                 285             


Val Pro Ile Asp Ile Cys Val Ser Glu Cys Ile Thr Pro Asn Gly Ser 
    290                 295                 300                 


Ile Ser Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Val Thr Tyr Gly 
305                 310                 315                 320 


Lys Cys Pro Lys Tyr Ile Arg Gln Asn Thr Leu Lys Leu Ala Thr Gly 
                325                 330                 335     


Met Arg Asn Val Pro Glu Lys Gln Ile Arg Gly Ile Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr 
        355                 360                 365             


Gly Phe Arg Tyr Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu 
    370                 375                 380                 


Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg 
385                 390                 395                 400 


Val Ile Glu Arg Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe 
                405                 410                 415     


Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp 
            420                 425                 430         


Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu 
        435                 440                 445             


Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ala Glu Met Asn Lys Leu 
    450                 455                 460                 


Phe Glu Lys Thr Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Met Gly 
465                 470                 475                 480 


Gly Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly 
                485                 490                 495     


Ser Ile Arg Asn Gly Thr Tyr Asp His Tyr Ile Tyr Arg Asp Glu Ala 
            500                 505                 510         


Leu Asn Asn Arg Phe Lys Ile Asp Ser Gly Gly Glu Ser Gln Val Arg 
        515                 520                 525             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    530                 535                 540                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser 
545                 550                 555                 560 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                565                 570                 575     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            580                 585                 590         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        595                 600                 605             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    610                 615                 620                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys 
625                 630                 635                 640 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                645                 650                 655     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            660                 665                 670         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        675                 680                 685             


Gly Ile Ala Lys Ser Arg Lys Ser 
    690                 695     


<210>  324
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  324

Met Glu Thr Thr Ile Ile Leu Ile Leu Leu Thr His Trp Val Tyr Ser 
1               5                   10                  15      


Gln Asn Pro Ile Ser Gly Asn Asn Thr Ala Thr Leu Cys Leu Gly His 
            20                  25                  30          


His Ala Val Ala Asn Gly Thr Leu Val Lys Thr Ile Thr Asp Asp Gln 
        35                  40                  45              


Ile Glu Val Thr Asn Ala Thr Glu Leu Val Glu Ser Ile Ser Met Gly 
    50                  55                  60                  


Lys Ile Cys Asn Asn Ser Tyr Arg Val Leu Asp Gly Arg Asn Cys Thr 
65                  70                  75                  80  


Leu Ile Asp Ala Met Leu Gly Asp Pro His Cys Asp Asp Phe Gln Tyr 
                85                  90                  95      


Glu Ser Trp Asp Leu Phe Ile Glu Arg Ser Ser Ala Ser Ser Asn Cys 
            100                 105                 110         


Phe Pro Tyr Asp Ile Pro Asp Tyr Ala Ser Leu Arg Ser Ile Val Ala 
        115                 120                 125             


Ser Ser Gly Thr Leu Glu Phe Thr Ala Glu Gly Phe Thr Trp Thr Gly 
    130                 135                 140                 


Val Thr Gln Asn Gly Arg Ser Gly Ala Cys Lys Arg Gly Ser Ala Asp 
145                 150                 155                 160 


Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Ser Gly Asn Ser Tyr 
                165                 170                 175     


Pro Thr Leu Asn Val Thr Met Pro Asn Asn Lys Asn Phe Asp Lys Leu 
            180                 185                 190         


Tyr Ile Trp Gly Ile His His Pro Ser Ser Asn Lys Glu Gln Thr Lys 
        195                 200                 205             


Leu Tyr Ile Gln Glu Ser Gly Arg Val Thr Val Ser Thr Glu Arg Ser 
    210                 215                 220                 


Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg Gly 
225                 230                 235                 240 


Gln Ser Gly Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly Asp 
                245                 250                 255     


Val Leu Met Ile Asn Ser Asn Gly Asn Leu Val Ala Pro Arg Gly Tyr 
            260                 265                 270         


Phe Lys Leu Arg Thr Gly Lys Ser Ser Val Met Arg Ser Asp Ala Leu 
        275                 280                 285             


Ile Asp Thr Cys Val Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile Pro 
    290                 295                 300                 


Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly Arg Cys 
305                 310                 315                 320 


Pro Lys Tyr Ile Arg Gln Asn Thr Leu Lys Leu Ala Thr Gly Met Arg 
                325                 330                 335     


Asn Val Pro Glu Lys Gln Ile Arg Gly Ile Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly Phe 
        355                 360                 365             


Arg Tyr Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Val Ile 
385                 390                 395                 400 


Glu Arg Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser Glu 
                405                 410                 415     


Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr Lys 
            420                 425                 430         


Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn 
        435                 440                 445             


Gln His Thr Ile Asp Leu Thr Asp Ala Glu Met Asn Lys Leu Phe Glu 
    450                 455                 460                 


Arg Thr Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Gly Gly 
465                 470                 475                 480 


Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser Ile 
                485                 490                 495     


Arg Asn Gly Thr Tyr Asp His Tyr Ile Tyr Arg Asp Glu Ala Leu Asn 
            500                 505                 510         


Asn Arg Phe Lys Ile Asp Ser Gly Gly Glu Ser Gln Val Arg Gln Gln 
        515                 520                 525             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    530                 535                 540                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr 
545                 550                 555                 560 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                565                 570                 575     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            580                 585                 590         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        595                 600                 605             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    610                 615                 620                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp 
625                 630                 635                 640 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                645                 650                 655     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            660                 665                 670         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        675                 680                 685             


Ala Lys Ser Arg Lys Ser 
    690                 


<210>  325
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  325

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Ala Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ser Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Asn Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Ala Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asn Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Gly Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ser Gly Gly Glu Ser Gln Val Arg Gln 
    530                 535                 540                 


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
545                 550                 555                 560 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
                565                 570                 575     


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
            580                 585                 590         


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
        595                 600                 605             


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
    610                 615                 620                 


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
625                 630                 635                 640 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
                645                 650                 655     


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
            660                 665                 670         


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
        675                 680                 685             


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
    690                 695                 700                 


Ile Ala Lys Ser Arg Lys Ser 
705                 710     


<210>  326
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  326

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Lys Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ile Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Tyr Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asn Lys Thr Gln Met Lys Ser Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Glu Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Lys His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Ser Gly Gly Glu Ser Gln Val 
    530                 535                 540                 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
545                 550                 555                 560 


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
                565                 570                 575     


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
            580                 585                 590         


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
        595                 600                 605             


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
    610                 615                 620                 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
625                 630                 635                 640 


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
                645                 650                 655     


Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
            660                 665                 670         


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
        675                 680                 685             


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
    690                 695                 700                 


Lys Gly Ile Ala Lys Ser Arg Lys Ser 
705                 710             


<210>  327
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  327

Met Lys Ala Arg Leu Leu Val Leu Leu Cys Ala Leu Ala Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Leu Ser Ala Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Phe Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
    130                 135                 140                 


Thr Thr Lys Gly Val Thr Ala Ala Cys Ser His Ala Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Gly Gly Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Thr Ser Thr Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Glu Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Ser Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
        275                 280                 285             


Met His Glu Cys Asn Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn 
                405                 410                 415     


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Ser Gly Gly Glu Ser Gln Val Arg Gln Gln 
        515                 520                 525             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    530                 535                 540                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr 
545                 550                 555                 560 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                565                 570                 575     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            580                 585                 590         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        595                 600                 605             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    610                 615                 620                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp 
625                 630                 635                 640 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                645                 650                 655     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            660                 665                 670         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        675                 680                 685             


Ala Lys Ser Arg Lys Ser 
    690                 


<210>  328
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  328

Met Glu Ala Arg Leu Leu Val Leu Leu Cys Ala Phe Ala Ala Thr Asn 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Phe Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Ala Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Lys Gly Val Thr Ala Ser Cys Ser His Asn Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Leu Tyr Pro 
                165                 170                 175     


Asn Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Asn Ile Gly Asp Gln Arg Ala Ile 
        195                 200                 205             


Tyr His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
        275                 280                 285             


Met Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Ser Gly Gly Glu Ser Gln Val Arg Gln Gln 
        515                 520                 525             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    530                 535                 540                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr 
545                 550                 555                 560 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                565                 570                 575     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            580                 585                 590         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        595                 600                 605             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    610                 615                 620                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp 
625                 630                 635                 640 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                645                 650                 655     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            660                 665                 670         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        675                 680                 685             


Ala Lys Ser Arg Lys Ser 
    690                 


<210>  329
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  329

Met Glu Ala Arg Leu Leu Val Leu Leu Cys Ala Phe Ala Ala Thr Asn 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Ser Gly Gly Glu Ser Gln Val Arg Gln Gln Phe 
        515                 520                 525             


Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met 
    530                 535                 540                 


Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His 
545                 550                 555                 560 


Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu 
                565                 570                 575     


Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val 
            580                 585                 590         


Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly 
        595                 600                 605             


Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser 
    610                 615                 620                 


Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp His 
625                 630                 635                 640 


Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu 
                645                 650                 655     


Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn 
            660                 665                 670         


Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala 
        675                 680                 685             


Lys Ser Arg Lys Ser 
    690             


<210>  330
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  330

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Lys Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Lys 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ser Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Ser Gly Gly Glu Ser Gln Val Arg Gln 
        515                 520                 525             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    530                 535                 540                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
545                 550                 555                 560 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                565                 570                 575     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            580                 585                 590         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        595                 600                 605             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    610                 615                 620                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
625                 630                 635                 640 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                645                 650                 655     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            660                 665                 670         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        675                 680                 685             


Ile Ala Lys Ser Arg Lys Ser 
    690                 695 


<210>  331
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  331

Met Lys Thr Ile Ile Ala Leu Ser His Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr Gln Leu Asn Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Val Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Tyr Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Ser Gly Gly Glu Ser Gln Val Arg Gln 
        515                 520                 525             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    530                 535                 540                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
545                 550                 555                 560 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                565                 570                 575     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            580                 585                 590         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        595                 600                 605             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    610                 615                 620                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
625                 630                 635                 640 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                645                 650                 655     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            660                 665                 670         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        675                 680                 685             


Ile Ala Lys Ser Arg Lys Ser 
    690                 695 


<210>  332
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  332

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Phe Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Ser Pro Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asn Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Ile Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu 
                405                 410                 415     


Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
            420                 425                 430         


Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 
    450                 455                 460                 


Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg 
            500                 505                 510         


Glu Glu Ile Ser Ser Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser 
    690         


<210>  333
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  333

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ile Asn Pro Ala Asn Asp Leu Cys Phe Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Arg Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asn Ala Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Asn Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Ile Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Ile Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu 
                405                 410                 415     


Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
            420                 425                 430         


Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 
    450                 455                 460                 


Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Phe Tyr His Arg Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg 
            500                 505                 510         


Glu Glu Ile Ser Ser Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser 
    690         


<210>  334
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  334

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ile Asn Pro Ala Asn Asp Leu Cys Phe Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Arg Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asp Asn Ala Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Asn Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Ile Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Gly Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu 
                405                 410                 415     


Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
            420                 425                 430         


Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 
    450                 455                 460                 


Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Phe Tyr His Arg Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg 
            500                 505                 510         


Glu Glu Ile Ser Ser Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser 
    690         


<210>  335
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  335

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Phe Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Arg Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Ala Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu 
                405                 410                 415     


Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
            420                 425                 430         


Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 
    450                 455                 460                 


Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Phe Tyr His Arg Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg 
            500                 505                 510         


Glu Glu Ile Ser Ser Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser 
    690         


<210>  336
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  336

Met Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser 
1               5                   10                  15      


Thr Gly Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His 
            20                  25                  30          


Val Val Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile 
        35                  40                  45              


Pro Leu Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly 
    50                  55                  60                  


Thr Glu Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp 
65                  70                  75                  80  


Leu Asp Val Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser 
                85                  90                  95      


Ala Arg Val Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys 
            100                 105                 110         


Phe Pro Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu 
        115                 120                 125             


Leu Arg Gly Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn 
    130                 135                 140                 


Ala Glu Asn Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser 
145                 150                 155                 160 


Cys Pro Asn Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp 
                165                 170                 175     


Ala Val Pro Lys Asn Asp Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr 
            180                 185                 190         


Ile Glu Val Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val 
        195                 200                 205             


Trp Gly Phe His Ser Asp Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly 
    210                 215                 220                 


Asp Ser Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr 
225                 230                 235                 240 


His Tyr Val Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly 
                245                 250                 255     


Gly Leu Pro Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys 
            260                 265                 270         


Ser Gly Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro 
        275                 280                 285             


Gln Lys Val Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser 
    290                 295                 300                 


Leu Pro Leu Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly 
305                 310                 315                 320 


Leu Asn Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile 
                325                 330                 335     


Gly Asn Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly 
            340                 345                 350         


Thr Lys Tyr Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe 
        355                 360                 365             


Gly Ala Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala 
    370                 375                 380                 


Gly Trp His Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala 
385                 390                 395                 400 


Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn 
                405                 410                 415     


Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser 
            420                 425                 430         


Gly Ala Met Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys 
        435                 440                 445             


Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala 
    450                 455                 460                 


Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu 
465                 470                 475                 480 


Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val 
                485                 490                 495     


Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr 
            500                 505                 510         


Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser 
        515                 520                 525             


Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Ser Gly Arg 
    530                 535                 540                 


Ser Ser Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys 
545                 550                 555                 560 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
                565                 570                 575     


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
            580                 585                 590         


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
        595                 600                 605             


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
    610                 615                 620                 


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
625                 630                 635                 640 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
                645                 650                 655     


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
            660                 665                 670         


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
        675                 680                 685             


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
    690                 695                 700                 


Ile Ala Lys Ser Arg Lys Ser Gly Ser 
705                 710             


<210>  337
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  337

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Lys Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ile Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Tyr Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asn Lys Thr Gln Met Lys Ser Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Glu Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Lys His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Ser Gly Gly Asp Ile Ile Lys 
    530                 535                 540                 


Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr 
545                 550                 555                 560 


Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly 
                565                 570                 575     


Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys 
            580                 585                 590         


Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser 
        595                 600                 605             


Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln 
    610                 615                 620                 


Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile 
625                 630                 635                 640 


Val Asp His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu 
                645                 650                 655     


Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp 
            660                 665                 670         


Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr 
        675                 680                 685             


Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly 
    690                 695                 700                 


Ser 
705 


<210>  338
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  338

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asn 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ser Gly Gly Asp Ile Ile Lys Leu Leu 
    530                 535                 540                 


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
545                 550                 555                 560 


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
                565                 570                 575     


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
            580                 585                 590         


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
        595                 600                 605             


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
    610                 615                 620                 


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
625                 630                 635                 640 


His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
                645                 650                 655     


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
            660                 665                 670         


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
        675                 680                 685             


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    690                 695                 700     


<210>  339
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  339

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ile Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Tyr Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asn Lys Thr Gln Met Lys Ser Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ser Gly Gly Asp Ile Ile Lys Leu Leu 
    530                 535                 540                 


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
545                 550                 555                 560 


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
                565                 570                 575     


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
            580                 585                 590         


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
        595                 600                 605             


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
    610                 615                 620                 


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
625                 630                 635                 640 


His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
                645                 650                 655     


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
            660                 665                 670         


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
        675                 680                 685             


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    690                 695                 700             


<210>  340
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  340

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Phe Pro Gly Cys Gly 
    50                  55                  60                  


Val Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
65                  70                  75                  80  


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
                85                  90                  95      


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
            100                 105                 110         


Ile Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln 
        115                 120                 125             


Ile Asn Gly Met Val Asn Arg Val Ile Glu Leu Met Glu Gln Gly Gly 
    130                 135                 140                 


Pro Asp Cys Tyr Leu Ala Glu Leu Leu Val Ala Leu Leu Asn Gln His 
145                 150                 155                 160 


Val Ile Asp Leu Thr Asp Ser Glu Met Arg Lys Leu Phe Glu Arg Thr 
                165                 170                 175     


Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe 
            180                 185                 190         


Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn 
        195                 200                 205             


Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg 
    210                 215                 220                 


Phe Gln Ile Lys Ser Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
225                 230                 235                 240 


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
                245                 250                 255     


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser 
            260                 265                 270         


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
        275                 280                 285             


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
    290                 295                 300                 


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
305                 310                 315                 320 


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
                325                 330                 335     


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp His Ala 
            340                 345                 350         


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
        355                 360                 365             


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
    370                 375                 380                 


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
385                 390                 395                 400 


Ser Arg Lys Ser 
                


<210>  341
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  341

Met Asn Thr Gln Ile Leu Val Phe Ala Leu Ile Ala Ile Ile Pro Thr 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr 
            20                  25                  30          


Lys Val Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr 
        35                  40                  45              


Glu Leu Val Phe Pro Gly Cys Gly Val Leu Lys Leu Ala Thr Gly Met 
    50                  55                  60                  


Lys Asn Val Pro Glu Ile Pro Lys Gly Arg Gly Leu Phe Gly Ala Ile 
65                  70                  75                  80  


Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Leu Ile Asp Gly Trp Tyr 
                85                  90                  95      


Gly Phe Arg His Gln Asn Ala Gln Gly Glu Gly Thr Ala Ala Asp Tyr 
            100                 105                 110         


Lys Ser Thr Gln Ser Ala Ile Asp Gln Ile Thr Gly Met Val Asn Arg 
        115                 120                 125             


Val Ile Glu Leu Met Glu Gln Gly Gly Pro Asp Cys Tyr Leu Ala Glu 
    130                 135                 140                 


Leu Leu Val Ala Met Leu Asn Gln His Val Ile Asp Leu Ala Asp Ser 
145                 150                 155                 160 


Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln Leu Arg Glu Asn 
                165                 170                 175     


Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Lys Cys Asp 
            180                 185                 190         


Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp His Ser Lys 
        195                 200                 205             


Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile Asp Ser Gly Gly 
    210                 215                 220                 


Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
225                 230                 235                 240 


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
                245                 250                 255     


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
            260                 265                 270         


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
        275                 280                 285             


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
    290                 295                 300                 


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
305                 310                 315                 320 


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
                325                 330                 335     


His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
            340                 345                 350         


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
        355                 360                 365             


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
    370                 375                 380                 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
385                 390                 395         


<210>  342
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  342

Met Tyr Lys Ile Val Val Ile Ile Ala Leu Leu Gly Ala Val Lys Gly 
1               5                   10                  15      


Leu Asp Lys Ile Cys Leu Gly His His Ala Val Ala Asn Gly Thr Ile 
            20                  25                  30          


Val Lys Thr Leu Thr Asn Glu Gln Glu Glu Val Thr Asn Ala Thr Glu 
        35                  40                  45              


Leu Val Phe Pro Gly Cys Gly Val Leu Met Leu Ala Thr Gly Met Arg 
    50                  55                  60                  


Asn Val Pro Glu Leu Ile Gln Gly Arg Gly Leu Phe Gly Ala Ile Ala 
65                  70                  75                  80  


Gly Phe Leu Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
                85                  90                  95      


Phe Arg His Gln Asn Ala Gln Gly Thr Gly Gln Ala Ala Asp Tyr Lys 
            100                 105                 110         


Ser Thr Gln Ala Ala Ile Asp Gln Ile Thr Gly Met Val Asn Arg Val 
        115                 120                 125             


Val Glu Leu Met Glu Gln Gly Gly Pro Asp Cys Tyr Leu Ala Glu Leu 
    130                 135                 140                 


Leu Val Ala Met Leu Asn Gln His Val Ile Asp Met Ala Asp Ser Glu 
145                 150                 155                 160 


Met Arg Asn Leu Tyr Glu Arg Val Arg Lys Gln Leu Arg Gln Asn Ala 
                165                 170                 175     


Glu Glu Asp Gly Lys Gly Cys Phe Glu Ile Tyr His Ala Cys Asp Asp 
            180                 185                 190         


Ser Cys Met Glu Ser Ile Arg Asn Asn Thr Tyr Asp His Ser Gln Tyr 
        195                 200                 205             


Arg Glu Glu Ala Leu Leu Asn Arg Leu Asn Ile Asn Ser Gly Gly Glu 
    210                 215                 220                 


Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn 
225                 230                 235                 240 


Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met 
                245                 250                 255     


Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu 
            260                 265                 270         


Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile 
        275                 280                 285             


Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala 
    290                 295                 300                 


Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr 
305                 310                 315                 320 


Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His 
                325                 330                 335     


Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr 
            340                 345                 350         


Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp 
        355                 360                 365             


Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp 
    370                 375                 380                 


Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
385                 390                 395     


<210>  343
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  343

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Gly Ser Gly Leu Arg Met Val Thr Gly Leu Arg Asn Ile Pro Gln 
    50                  55                  60                  


Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
65                  70                  75                  80  


Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn 
                85                  90                  95      


Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala 
            100                 105                 110         


Ile Asn Gly Ile Thr Asn Met Val Asn Ser Val Ile Glu Lys Met Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Thr Asp Leu Ala Glu Leu Leu Val Leu Leu Leu 
    130                 135                 140                 


Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr 
145                 150                 155                 160 


Glu Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn 
                165                 170                 175     


Gly Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser 
            180                 185                 190         


Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys 
        195                 200                 205             


Leu Asn Arg Glu Lys Ile Asp Ser Gly Gly Glu Ser Gln Val Arg Gln 
    210                 215                 220                 


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
225                 230                 235                 240 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr 
                245                 250                 255     


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
            260                 265                 270         


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
        275                 280                 285             


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
    290                 295                 300                 


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
305                 310                 315                 320 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys 
                325                 330                 335     


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
            340                 345                 350         


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
        355                 360                 365             


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
    370                 375                 380                 


Ile Ala Lys Ser Arg Lys Ser 
385                 390     


<210>  344
<211>  7
<212>  PRT
<213>  Tobacco etch virus

<400>  344

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  345
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  345
tgactgtgaa cgttcgagat ga                                                22


<210>  346

<400>  346
000

<210>  347

<400>  347
000

<210>  348

<400>  348
000

<210>  349

<400>  349
000

<210>  350

<400>  350
000

<210>  351

<400>  351
000

<210>  352

<400>  352
000

<210>  353

<400>  353
000

<210>  354

<400>  354
000

<210>  355

<400>  355
000

<210>  356

<400>  356
000

<210>  357

<400>  357
000

<210>  358

<400>  358
000

<210>  359

<400>  359
000

<210>  360

<400>  360
000

<210>  361

<400>  361
000

<210>  362

<400>  362
000

<210>  363

<400>  363
000

<210>  364

<400>  364
000

<210>  365

<400>  365
000

<210>  366

<400>  366
000

<210>  367

<400>  367
000

<210>  368

<400>  368
000

<210>  369

<400>  369
000

<210>  370

<400>  370
000

<210>  371

<400>  371
000

<210>  372

<400>  372
000

<210>  373

<400>  373
000

<210>  374

<400>  374
000

<210>  375

<400>  375
000

<210>  376

<400>  376
000

<210>  377

<400>  377
000

<210>  378

<400>  378
000

<210>  379

<400>  379
000

<210>  380

<400>  380
000

<210>  381

<400>  381
000

<210>  382

<400>  382
000

<210>  383

<400>  383
000

<210>  384

<400>  384
000

<210>  385

<400>  385
000

<210>  386

<400>  386
000

<210>  387

<400>  387
000

<210>  388

<400>  388
000

<210>  389

<400>  389
000

<210>  390

<400>  390
000

<210>  391

<400>  391
000

<210>  392

<400>  392
000

<210>  393

<400>  393
000

<210>  394

<400>  394
000

<210>  395

<400>  395
000

<210>  396

<400>  396
000

<210>  397

<400>  397
000

<210>  398

<400>  398
000

<210>  399

<400>  399
000

<210>  400

<400>  400
000

<210>  401
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  401

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Glu Ala 
            20                  25                  30          


Ala Leu Leu Val Cys Gln Tyr Thr Ile Gln Ser Leu Ile His Leu Thr 
        35                  40                  45              


Gly Glu Asp Pro Gly Phe Phe Asn Val Glu Ile Pro Glu Phe Pro Phe 
    50                  55                  60                  


Tyr Pro Thr Cys Asn Val Cys Thr Ala Asp Val Asn Val Thr Ile Asn 
65                  70                  75                  80  


Phe Asp Val Gly Gly Lys Lys His Gln Leu Asp Leu Asp Phe Gly Gln 
                85                  90                  95      


Leu Thr Pro His Thr Lys Ala Val Tyr Gln Pro Arg Gly Ala Phe Gly 
            100                 105                 110         


Gly Ser Glu Asn Ala Thr Asn Leu Phe Leu Leu Glu Leu Leu Gly Ala 
        115                 120                 125             


Gly Glu Leu Ala Leu Thr Met Arg Ser Lys Lys Leu Pro Ile Asn Val 
    130                 135                 140                 


Thr Thr Gly Glu Glu Gln Gln Val Ser Leu Glu Ser Val Asp Val Tyr 
145                 150                 155                 160 


Phe Gln Asp Val Phe Gly Thr Met Trp Cys His His Ala Glu Met Gln 
                165                 170                 175     


Asn Pro Val Tyr Leu Ile Pro Glu Thr Val Pro Tyr Ile Lys Trp Asp 
            180                 185                 190         


Asn Cys Asn Ser Thr Asn Ile Thr Ala Val Val Arg Ala Gln Gly Leu 
        195                 200                 205             


Asp Val Thr Leu Pro Leu Ser Leu Pro Thr Ser Ala Gln Asp Ser Asn 
    210                 215                 220                 


Phe Ser Val Lys Thr Glu Met Leu Gly Asn Glu Ile Asp Ile Glu Cys 
225                 230                 235                 240 


Ile Met Glu Asp Gly Glu Ile Ser Gln Val Leu Pro Gly Asp Asn Lys 
                245                 250                 255     


Phe Asn Ile Thr Cys Ser Gly Tyr Glu Ser His Val Pro Ser Gly Gly 
            260                 265                 270         


Ile Leu Thr Ser Thr Ser Pro Val Ala Thr Pro Ile Pro Gly Thr Gly 
        275                 280                 285             


Tyr Ala Tyr Ser Leu Arg Leu Thr Pro Arg Pro Val Ser Arg Phe Leu 
    290                 295                 300                 


Gly Asn Asn Ser Ile Leu Tyr Val Phe Tyr Ser Gly Asn Gly Pro Lys 
305                 310                 315                 320 


Ala Ser Gly Gly Asp Tyr Cys Ile Gln Ser Asn Ile Val Phe Ser Asp 
                325                 330                 335     


Glu Ile Pro Ala Ser Gln Asp Met Pro Thr Asn Thr Thr Asp Ile Thr 
            340                 345                 350         


Tyr Val Gly Asp Asn Ala Thr Tyr Ser Val Pro Met Val Thr Ser Glu 
        355                 360                 365             


Asp Ala Asn Ser Pro Asn Val Thr Val Thr Ala Phe Trp Ala Trp Pro 
    370                 375                 380                 


Asn Asn Thr Glu Thr Asp Phe Lys Cys Lys Trp Thr Leu Thr Ser Gly 
385                 390                 395                 400 


Thr Pro Ser Gly Cys Glu Asn Ile Ser Gly Ala Phe Ala Ser Asn Arg 
                405                 410                 415     


Thr Phe Asp Ile Thr Val Ser Gly Leu Gly Thr Ala Pro Lys Thr Leu 
            420                 425                 430         


Ile Ile Thr Arg Thr Ala Thr Asn Ala Thr Thr Thr Thr His Lys Val 
        435                 440                 445             


Ile Phe Ser Lys Ala Pro Glu Gly Ser Glu Ser Gln Val Arg Gln Gln 
    450                 455                 460                 


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
465                 470                 475                 480 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr 
                485                 490                 495     


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
            500                 505                 510         


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
        515                 520                 525             


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
    530                 535                 540                 


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
545                 550                 555                 560 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp 
                565                 570                 575     


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
            580                 585                 590         


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
        595                 600                 605             


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
    610                 615                 620                 


Ala Lys Ser Arg Lys Ser 
625                 630 


<210>  402
<211>  1032
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  402

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly 
    130                 135                 140                 


Ser Ser Asn Gly Ser Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser 
145                 150                 155                 160 


Ser Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
                165                 170                 175     


Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His 
            180                 185                 190         


Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val Pro 
        195                 200                 205             


Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp 
    210                 215                 220                 


Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly 
225                 230                 235                 240 


Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser 
                245                 250                 255     


Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile 
            260                 265                 270         


Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys 
        275                 280                 285             


Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His 
    290                 295                 300                 


Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu 
305                 310                 315                 320 


Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys 
                325                 330                 335     


Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His 
            340                 345                 350         


Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg 
        355                 360                 365             


Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp Tyr 
    370                 375                 380                 


Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn 
385                 390                 395                 400 


Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met 
                405                 410                 415     


Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu 
            420                 425                 430         


Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr Leu 
        435                 440                 445             


Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala 
    450                 455                 460                 


Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys 
465                 470                 475                 480 


Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr 
                485                 490                 495     


Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala 
            500                 505                 510         


Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr 
        515                 520                 525             


Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro 
    530                 535                 540                 


Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu 
545                 550                 555                 560 


Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val 
                565                 570                 575     


Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu 
            580                 585                 590         


Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu 
        595                 600                 605             


Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg 
    610                 615                 620                 


Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu 
625                 630                 635                 640 


Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala Pro 
                645                 650                 655     


Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp Gly 
            660                 665                 670         


Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His 
        675                 680                 685             


Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile 
    690                 695                 700                 


Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val 
705                 710                 715                 720 


Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser 
                725                 730                 735     


Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala Val 
            740                 745                 750         


Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr 
        755                 760                 765             


Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu 
    770                 775                 780                 


Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln 
785                 790                 795                 800 


Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val 
                805                 810                 815     


His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly 
            820                 825                 830         


Leu Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        835                 840                 845             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Ser Gln Val Arg 
    850                 855                 860                 


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
865                 870                 875                 880 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Ser 
                885                 890                 895     


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
            900                 905                 910         


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
        915                 920                 925             


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
    930                 935                 940                 


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
945                 950                 955                 960 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Cys 
                965                 970                 975     


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
            980                 985                 990         


His Glu Glu Glu Val Leu Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu 
        995                 1000                 1005             


Ile Gly  Asn Glu Asn His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val 
    1010                 1015                 1020             


Lys Gly  Ile Ala Lys Ser Arg  Lys Ser 
    1025                 1030         


<210>  403
<211>  1001
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  403

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu 
            20                  25                  30          


Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu 
        35                  40                  45              


Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser 
    50                  55                  60                  


Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly 
65                  70                  75                  80  


Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser 
                85                  90                  95      


Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu 
            100                 105                 110         


Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly 
145                 150                 155                 160 


His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val 
                165                 170                 175     


Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu 
            180                 185                 190         


Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser 
        195                 200                 205             


Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val 
    210                 215                 220                 


Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val 
225                 230                 235                 240 


Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu 
                245                 250                 255     


Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro 
            260                 265                 270         


His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala 
        275                 280                 285             


Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser 
    290                 295                 300                 


Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu 
305                 310                 315                 320 


His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu 
                325                 330                 335     


Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp 
            340                 345                 350         


Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His 
        355                 360                 365             


Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr 
    370                 375                 380                 


Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu 
385                 390                 395                 400 


Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr 
                405                 410                 415     


Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His 
            420                 425                 430         


Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala 
        435                 440                 445             


Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys 
    450                 455                 460                 


Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu 
465                 470                 475                 480 


Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu 
                485                 490                 495     


Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr 
            500                 505                 510         


Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val 
        515                 520                 525             


Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr 
    530                 535                 540                 


Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu 
545                 550                 555                 560 


Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln 
                565                 570                 575     


Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu 
            580                 585                 590         


Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr 
        595                 600                 605             


Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala 
    610                 615                 620                 


Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp 
625                 630                 635                 640 


Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp 
                645                 650                 655     


His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met 
            660                 665                 670         


Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu 
        675                 680                 685             


Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser 
    690                 695                 700                 


Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala 
705                 710                 715                 720 


Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg 
                725                 730                 735     


Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp 
            740                 745                 750         


Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val 
        755                 760                 765             


Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His 
    770                 775                 780                 


Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala 
785                 790                 795                 800 


Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser Gly Gly Gly Ser 
                805                 810                 815     


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Ser Gln Val 
            820                 825                 830         


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
        835                 840                 845             


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
    850                 855                 860                 


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
865                 870                 875                 880 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
                885                 890                 895     


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
            900                 905                 910         


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
        915                 920                 925             


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
    930                 935                 940                 


Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
945                 950                 955                 960 


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
                965                 970                 975     


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
            980                 985                 990         


Lys Gly Ile Ala Lys Ser Arg Lys  Ser 
        995                 1000     


<210>  404
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  404

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly 
    130                 135                 140                 


Ser Ser Asn Gly Ser Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser 
145                 150                 155                 160 


Ser Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
                165                 170                 175     


Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His 
            180                 185                 190         


Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val Pro 
        195                 200                 205             


Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp 
    210                 215                 220                 


Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly 
225                 230                 235                 240 


Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser 
                245                 250                 255     


Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile 
            260                 265                 270         


Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys 
        275                 280                 285             


Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His 
    290                 295                 300                 


Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu 
305                 310                 315                 320 


Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys 
                325                 330                 335     


Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His 
            340                 345                 350         


Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg 
        355                 360                 365             


Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp Tyr 
    370                 375                 380                 


Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn 
385                 390                 395                 400 


Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met 
                405                 410                 415     


Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu 
            420                 425                 430         


Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr Leu 
        435                 440                 445             


Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala 
    450                 455                 460                 


Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys 
465                 470                 475                 480 


Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr 
                485                 490                 495     


Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala 
            500                 505                 510         


Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr 
        515                 520                 525             


Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro 
    530                 535                 540                 


Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu 
545                 550                 555                 560 


Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val 
                565                 570                 575     


Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu 
            580                 585                 590         


Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu 
        595                 600                 605             


Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg 
    610                 615                 620                 


Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu 
625                 630                 635                 640 


Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala Pro 
                645                 650                 655     


Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp Gly 
            660                 665                 670         


Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His 
        675                 680                 685             


Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile 
    690                 695                 700                 


Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val 
705                 710                 715                 720 


Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser 
                725                 730                 735     


Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala Val 
            740                 745                 750         


Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr 
        755                 760                 765             


Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu 
    770                 775                 780                 


Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln 
785                 790                 795                 800 


Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val 
                805                 810                 815     


His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly 
            820                 825                 830         


Leu Tyr Glu Glu Arg Ala Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro 
        835                 840                 845             


Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu 
    850                 855                 860                 


Ser Thr Phe Leu Gly Ser Gly Ser Gly Ser Gly Leu Val Pro Arg Gly 
865                 870                 875                 880 


Ser Gly Ala Gly Gly Gly His His His His His His 
                885                 890         


<210>  405
<211>  861
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  405

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu 
            20                  25                  30          


Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu 
        35                  40                  45              


Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser 
    50                  55                  60                  


Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly 
65                  70                  75                  80  


Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser 
                85                  90                  95      


Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu 
            100                 105                 110         


Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly 
145                 150                 155                 160 


His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val 
                165                 170                 175     


Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu 
            180                 185                 190         


Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser 
        195                 200                 205             


Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val 
    210                 215                 220                 


Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val 
225                 230                 235                 240 


Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu 
                245                 250                 255     


Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro 
            260                 265                 270         


His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala 
        275                 280                 285             


Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser 
    290                 295                 300                 


Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu 
305                 310                 315                 320 


His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu 
                325                 330                 335     


Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp 
            340                 345                 350         


Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His 
        355                 360                 365             


Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr 
    370                 375                 380                 


Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu 
385                 390                 395                 400 


Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr 
                405                 410                 415     


Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His 
            420                 425                 430         


Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala 
        435                 440                 445             


Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys 
    450                 455                 460                 


Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu 
465                 470                 475                 480 


Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu 
                485                 490                 495     


Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr 
            500                 505                 510         


Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val 
        515                 520                 525             


Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr 
    530                 535                 540                 


Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu 
545                 550                 555                 560 


Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln 
                565                 570                 575     


Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu 
            580                 585                 590         


Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr 
        595                 600                 605             


Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala 
    610                 615                 620                 


Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp 
625                 630                 635                 640 


Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp 
                645                 650                 655     


His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met 
            660                 665                 670         


Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu 
        675                 680                 685             


Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser 
    690                 695                 700                 


Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala 
705                 710                 715                 720 


Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg 
                725                 730                 735     


Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp 
            740                 745                 750         


Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val 
        755                 760                 765             


Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His 
    770                 775                 780                 


Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala 
785                 790                 795                 800 


Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser Gly Tyr Ile Pro Glu Ala 
                805                 810                 815     


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
            820                 825                 830         


Leu Ser Thr Phe Leu Gly Ser Gly Ser Gly Ser Gly Leu Val Pro Arg 
        835                 840                 845             


Gly Ser Gly Ala Gly Gly Gly His His His His His His 
    850                 855                 860     


<210>  406
<211>  863
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  406

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly 
    130                 135                 140                 


Ser Ser Asn Gly Ser Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser 
145                 150                 155                 160 


Ser Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
                165                 170                 175     


Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His 
            180                 185                 190         


Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val Pro 
        195                 200                 205             


Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp 
    210                 215                 220                 


Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly 
225                 230                 235                 240 


Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser 
                245                 250                 255     


Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile 
            260                 265                 270         


Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys 
        275                 280                 285             


Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His 
    290                 295                 300                 


Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu 
305                 310                 315                 320 


Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys 
                325                 330                 335     


Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His 
            340                 345                 350         


Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg 
        355                 360                 365             


Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp Tyr 
    370                 375                 380                 


Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn 
385                 390                 395                 400 


Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met 
                405                 410                 415     


Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu 
            420                 425                 430         


Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr Leu 
        435                 440                 445             


Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala 
    450                 455                 460                 


Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys 
465                 470                 475                 480 


Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr 
                485                 490                 495     


Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala 
            500                 505                 510         


Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr 
        515                 520                 525             


Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro 
    530                 535                 540                 


Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu 
545                 550                 555                 560 


Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val 
                565                 570                 575     


Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu 
            580                 585                 590         


Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu 
        595                 600                 605             


Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg 
    610                 615                 620                 


Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu 
625                 630                 635                 640 


Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala Pro 
                645                 650                 655     


Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp Gly 
            660                 665                 670         


Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His 
        675                 680                 685             


Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile 
    690                 695                 700                 


Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val 
705                 710                 715                 720 


Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser 
                725                 730                 735     


Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala Val 
            740                 745                 750         


Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr 
        755                 760                 765             


Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu 
    770                 775                 780                 


Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln 
785                 790                 795                 800 


Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val 
                805                 810                 815     


His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly 
            820                 825                 830         


Leu Tyr Glu Glu Arg Ala Ser Gly Ser Gly Ser Gly Ser Gly Leu Val 
        835                 840                 845             


Pro Arg Gly Ser Gly Ala Gly Gly Gly His His His His His His 
    850                 855                 860             


<210>  407
<211>  832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  407

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu 
            20                  25                  30          


Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu 
        35                  40                  45              


Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser 
    50                  55                  60                  


Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly 
65                  70                  75                  80  


Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser 
                85                  90                  95      


Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu 
            100                 105                 110         


Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly 
145                 150                 155                 160 


His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val 
                165                 170                 175     


Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu 
            180                 185                 190         


Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser 
        195                 200                 205             


Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val 
    210                 215                 220                 


Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val 
225                 230                 235                 240 


Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu 
                245                 250                 255     


Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro 
            260                 265                 270         


His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala 
        275                 280                 285             


Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser 
    290                 295                 300                 


Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu 
305                 310                 315                 320 


His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu 
                325                 330                 335     


Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp 
            340                 345                 350         


Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His 
        355                 360                 365             


Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr 
    370                 375                 380                 


Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu 
385                 390                 395                 400 


Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr 
                405                 410                 415     


Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His 
            420                 425                 430         


Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala 
        435                 440                 445             


Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys 
    450                 455                 460                 


Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu 
465                 470                 475                 480 


Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu 
                485                 490                 495     


Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr 
            500                 505                 510         


Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val 
        515                 520                 525             


Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr 
    530                 535                 540                 


Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu 
545                 550                 555                 560 


Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln 
                565                 570                 575     


Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu 
            580                 585                 590         


Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr 
        595                 600                 605             


Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala 
    610                 615                 620                 


Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp 
625                 630                 635                 640 


Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp 
                645                 650                 655     


His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met 
            660                 665                 670         


Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu 
        675                 680                 685             


Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser 
    690                 695                 700                 


Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala 
705                 710                 715                 720 


Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg 
                725                 730                 735     


Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp 
            740                 745                 750         


Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val 
        755                 760                 765             


Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His 
    770                 775                 780                 


Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala 
785                 790                 795                 800 


Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser Gly Ser Gly Ser Gly Leu 
                805                 810                 815     


Val Pro Arg Gly Ser Gly Ala Gly Gly Gly His His His His His His 
            820                 825                 830         


<210>  408
<211>  870
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  408

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser 
        835                 840                 845             


Gly Ser Gly Ser Gly Leu Val Pro Arg Gly Ser Gly Ala Gly Gly Gly 
    850                 855                 860                 


His His His His His His 
865                 870 


<210>  409
<211>  852
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  409

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu 
                165                 170                 175     


Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu 
            180                 185                 190         


Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala 
        195                 200                 205             


Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile 
    210                 215                 220                 


Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp 
225                 230                 235                 240 


Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val 
                245                 250                 255     


His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser 
            260                 265                 270         


Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro 
        275                 280                 285             


Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu 
    290                 295                 300                 


Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly 
305                 310                 315                 320 


Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu 
                325                 330                 335     


Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp 
            340                 345                 350         


Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala 
        355                 360                 365             


Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr 
    370                 375                 380                 


Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser 
385                 390                 395                 400 


Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln 
                405                 410                 415     


Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu 
            420                 425                 430         


Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe 
        435                 440                 445             


Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu 
    450                 455                 460                 


Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile 
465                 470                 475                 480 


Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly 
                485                 490                 495     


Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu 
            500                 505                 510         


Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala 
        515                 520                 525             


Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly 
    530                 535                 540                 


Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln 
545                 550                 555                 560 


Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val 
                565                 570                 575     


Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu 
            580                 585                 590         


Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile 
        595                 600                 605             


Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe 
    610                 615                 620                 


Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu 
625                 630                 635                 640 


Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser 
                645                 650                 655     


Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp 
            660                 665                 670         


Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp 
        675                 680                 685             


Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser 
    690                 695                 700                 


Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr 
705                 710                 715                 720 


Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys 
                725                 730                 735     


Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln 
            740                 745                 750         


Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu 
        755                 760                 765             


Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr 
    770                 775                 780                 


Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe 
785                 790                 795                 800 


Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val 
                805                 810                 815     


Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser Gly Ser 
            820                 825                 830         


Gly Ser Gly Leu Val Pro Arg Gly Ser Gly Ala Gly Gly Gly His His 
        835                 840                 845             


His His His His 
    850         


<210>  410
<211>  1007
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  410

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu 
            20                  25                  30          


Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu 
        35                  40                  45              


Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser 
    50                  55                  60                  


Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly 
65                  70                  75                  80  


Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser 
                85                  90                  95      


Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu 
            100                 105                 110         


Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg 
        115                 120                 125             


Tyr Ala Trp His Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
145                 150                 155                 160 


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
                165                 170                 175     


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
            180                 185                 190         


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
        195                 200                 205             


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
    210                 215                 220                 


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
225                 230                 235                 240 


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
                245                 250                 255     


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
            260                 265                 270         


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
        275                 280                 285             


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
    290                 295                 300                 


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
305                 310                 315                 320 


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
                325                 330                 335     


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
            340                 345                 350         


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
        355                 360                 365             


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
    370                 375                 380                 


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
385                 390                 395                 400 


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
                405                 410                 415     


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
            420                 425                 430         


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
        435                 440                 445             


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
    450                 455                 460                 


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
465                 470                 475                 480 


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
                485                 490                 495     


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
            500                 505                 510         


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
        515                 520                 525             


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
    530                 535                 540                 


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
545                 550                 555                 560 


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
                565                 570                 575     


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
            580                 585                 590         


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
        595                 600                 605             


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
    610                 615                 620                 


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
625                 630                 635                 640 


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
                645                 650                 655     


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
            660                 665                 670         


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
        675                 680                 685             


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
    690                 695                 700                 


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
705                 710                 715                 720 


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
                725                 730                 735     


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
            740                 745                 750         


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
        755                 760                 765             


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
    770                 775                 780                 


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
785                 790                 795                 800 


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
                805                 810                 815     


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
            820                 825                 830         


Gly Ser Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys 
        835                 840                 845             


Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr 
    850                 855                 860                 


Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly 
865                 870                 875                 880 


Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys 
                885                 890                 895     


Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser 
            900                 905                 910         


Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln 
        915                 920                 925             


Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile 
    930                 935                 940                 


Val Asp His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu 
945                 950                 955                 960 


Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp 
                965                 970                 975     


Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr 
            980                 985                 990         


Leu Ala Asp Gln Tyr Val Lys Gly  Ile Ala Lys Ser Arg  Lys Ser 
        995                 1000                 1005         


<210>  411
<211>  881
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  411

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu 
                165                 170                 175     


Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu 
            180                 185                 190         


Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala 
        195                 200                 205             


Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile 
    210                 215                 220                 


Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp 
225                 230                 235                 240 


Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val 
                245                 250                 255     


His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser 
            260                 265                 270         


Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro 
        275                 280                 285             


Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu 
    290                 295                 300                 


Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly 
305                 310                 315                 320 


Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu 
                325                 330                 335     


Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp 
            340                 345                 350         


Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala 
        355                 360                 365             


Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr 
    370                 375                 380                 


Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser 
385                 390                 395                 400 


Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln 
                405                 410                 415     


Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu 
            420                 425                 430         


Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe 
        435                 440                 445             


Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu 
    450                 455                 460                 


Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile 
465                 470                 475                 480 


Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly 
                485                 490                 495     


Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu 
            500                 505                 510         


Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala 
        515                 520                 525             


Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly 
    530                 535                 540                 


Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln 
545                 550                 555                 560 


Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val 
                565                 570                 575     


Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu 
            580                 585                 590         


Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile 
        595                 600                 605             


Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe 
    610                 615                 620                 


Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu 
625                 630                 635                 640 


Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser 
                645                 650                 655     


Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp 
            660                 665                 670         


Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp 
        675                 680                 685             


Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser 
    690                 695                 700                 


Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr 
705                 710                 715                 720 


Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys 
                725                 730                 735     


Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln 
            740                 745                 750         


Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu 
        755                 760                 765             


Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr 
    770                 775                 780                 


Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe 
785                 790                 795                 800 


Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val 
                805                 810                 815     


Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser Gly Tyr 
            820                 825                 830         


Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly 
        835                 840                 845             


Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser Gly Ser Gly Ser Gly 
    850                 855                 860                 


Leu Val Pro Arg Gly Ser Gly Ala Gly Gly Gly His His His His His 
865                 870                 875                 880 


His 
    


<210>  412
<211>  899
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  412

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser 
        835                 840                 845             


Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
    850                 855                 860                 


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser Gly Ser Gly 
865                 870                 875                 880 


Ser Gly Leu Val Pro Arg Gly Ser Gly Ala Gly Gly Gly His His His 
                885                 890                 895     


His His His 
            


<210>  413
<211>  1021
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  413

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu 
                165                 170                 175     


Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu 
            180                 185                 190         


Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala 
        195                 200                 205             


Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile 
    210                 215                 220                 


Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp 
225                 230                 235                 240 


Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val 
                245                 250                 255     


His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser 
            260                 265                 270         


Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro 
        275                 280                 285             


Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu 
    290                 295                 300                 


Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly 
305                 310                 315                 320 


Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu 
                325                 330                 335     


Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp 
            340                 345                 350         


Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala 
        355                 360                 365             


Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr 
    370                 375                 380                 


Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser 
385                 390                 395                 400 


Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln 
                405                 410                 415     


Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu 
            420                 425                 430         


Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe 
        435                 440                 445             


Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu 
    450                 455                 460                 


Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile 
465                 470                 475                 480 


Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly 
                485                 490                 495     


Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu 
            500                 505                 510         


Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala 
        515                 520                 525             


Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly 
    530                 535                 540                 


Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln 
545                 550                 555                 560 


Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val 
                565                 570                 575     


Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu 
            580                 585                 590         


Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile 
        595                 600                 605             


Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe 
    610                 615                 620                 


Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu 
625                 630                 635                 640 


Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser 
                645                 650                 655     


Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp 
            660                 665                 670         


Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp 
        675                 680                 685             


Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser 
    690                 695                 700                 


Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr 
705                 710                 715                 720 


Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys 
                725                 730                 735     


Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln 
            740                 745                 750         


Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu 
        755                 760                 765             


Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr 
    770                 775                 780                 


Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe 
785                 790                 795                 800 


Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val 
                805                 810                 815     


Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser 
            820                 825                 830         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        835                 840                 845             


Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
    850                 855                 860                 


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
865                 870                 875                 880 


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
                885                 890                 895     


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
            900                 905                 910         


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
        915                 920                 925             


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
    930                 935                 940                 


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
945                 950                 955                 960 


His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
                965                 970                 975     


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
            980                 985                 990         


Asp Lys Ile Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
        995                 1000                 1005             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser 
    1010                 1015                 1020     


<210>  414
<211>  1039
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  414

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
    850                 855                 860                 


Gly Ser Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys 
865                 870                 875                 880 


Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr 
                885                 890                 895     


Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly 
            900                 905                 910         


Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys 
        915                 920                 925             


Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser 
    930                 935                 940                 


Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln 
945                 950                 955                 960 


Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile 
                965                 970                 975     


Val Asp His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu 
            980                 985                 990         


Gln Trp Tyr Val Ala Glu Gln His  Glu Glu Glu Val Leu  Phe Lys Asp 
        995                 1000                 1005             


Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu 
    1010                 1015                 1020             


Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys 
    1025                 1030                 1035             


Ser 
    


<210>  415
<211>  838
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  415

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu 
            20                  25                  30          


Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu 
        35                  40                  45              


Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser 
    50                  55                  60                  


Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly 
65                  70                  75                  80  


Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser 
                85                  90                  95      


Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu 
            100                 105                 110         


Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg 
        115                 120                 125             


Tyr Ala Trp His Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
145                 150                 155                 160 


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
                165                 170                 175     


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
            180                 185                 190         


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
        195                 200                 205             


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
    210                 215                 220                 


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
225                 230                 235                 240 


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
                245                 250                 255     


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
            260                 265                 270         


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
        275                 280                 285             


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
    290                 295                 300                 


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
305                 310                 315                 320 


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
                325                 330                 335     


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
            340                 345                 350         


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
        355                 360                 365             


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
    370                 375                 380                 


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
385                 390                 395                 400 


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
                405                 410                 415     


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
            420                 425                 430         


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
        435                 440                 445             


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
    450                 455                 460                 


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
465                 470                 475                 480 


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
                485                 490                 495     


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
            500                 505                 510         


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
        515                 520                 525             


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
    530                 535                 540                 


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
545                 550                 555                 560 


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
                565                 570                 575     


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
            580                 585                 590         


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
        595                 600                 605             


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
    610                 615                 620                 


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
625                 630                 635                 640 


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
                645                 650                 655     


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
            660                 665                 670         


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
        675                 680                 685             


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
    690                 695                 700                 


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
705                 710                 715                 720 


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
                725                 730                 735     


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
            740                 745                 750         


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
        755                 760                 765             


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
    770                 775                 780                 


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
785                 790                 795                 800 


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser 
                805                 810                 815     


Gly Ser Gly Ser Gly Leu Val Pro Arg Gly Ser Gly Ala Gly Gly Gly 
            820                 825                 830         


His His His His His His 
        835             


<210>  416
<211>  867
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  416

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu 
            20                  25                  30          


Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu 
        35                  40                  45              


Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser 
    50                  55                  60                  


Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly 
65                  70                  75                  80  


Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser 
                85                  90                  95      


Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu 
            100                 105                 110         


Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg 
        115                 120                 125             


Tyr Ala Trp His Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
145                 150                 155                 160 


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
                165                 170                 175     


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
            180                 185                 190         


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
        195                 200                 205             


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
    210                 215                 220                 


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
225                 230                 235                 240 


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
                245                 250                 255     


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
            260                 265                 270         


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
        275                 280                 285             


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
    290                 295                 300                 


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
305                 310                 315                 320 


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
                325                 330                 335     


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
            340                 345                 350         


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
        355                 360                 365             


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
    370                 375                 380                 


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
385                 390                 395                 400 


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
                405                 410                 415     


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
            420                 425                 430         


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
        435                 440                 445             


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
    450                 455                 460                 


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
465                 470                 475                 480 


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
                485                 490                 495     


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
            500                 505                 510         


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
        515                 520                 525             


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
    530                 535                 540                 


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
545                 550                 555                 560 


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
                565                 570                 575     


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
            580                 585                 590         


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
        595                 600                 605             


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
    610                 615                 620                 


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
625                 630                 635                 640 


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
                645                 650                 655     


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
            660                 665                 670         


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
        675                 680                 685             


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
    690                 695                 700                 


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
705                 710                 715                 720 


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
                725                 730                 735     


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
            740                 745                 750         


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
        755                 760                 765             


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
    770                 775                 780                 


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
785                 790                 795                 800 


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser 
                805                 810                 815     


Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
            820                 825                 830         


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser Gly Ser Gly 
        835                 840                 845             


Ser Gly Leu Val Pro Arg Gly Ser Gly Ala Gly Gly Gly His His His 
    850                 855                 860                 


His His His 
865         


<210>  417
<211>  1019
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  417

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile 
                165                 170                 175     


Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala 
            180                 185                 190         


Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val 
        195                 200                 205             


Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys 
    210                 215                 220                 


Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro 
225                 230                 235                 240 


Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro 
                245                 250                 255     


Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro 
            260                 265                 270         


Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr 
        275                 280                 285             


Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr 
    290                 295                 300                 


Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met 
305                 310                 315                 320 


Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly 
                325                 330                 335     


Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro 
            340                 345                 350         


Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser 
        355                 360                 365             


Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn 
    370                 375                 380                 


Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala 
385                 390                 395                 400 


Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu 
                405                 410                 415     


Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr 
            420                 425                 430         


Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val 
        435                 440                 445             


Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp 
    450                 455                 460                 


Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly 
465                 470                 475                 480 


Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu 
                485                 490                 495     


Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly 
            500                 505                 510         


His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val 
        515                 520                 525             


Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr 
    530                 535                 540                 


Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu 
545                 550                 555                 560 


His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu 
                565                 570                 575     


Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu 
            580                 585                 590         


Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu 
        595                 600                 605             


Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro 
    610                 615                 620                 


Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser 
625                 630                 635                 640 


Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala 
                645                 650                 655     


Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp 
            660                 665                 670         


Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val 
        675                 680                 685             


Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp 
    690                 695                 700                 


Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu 
705                 710                 715                 720 


Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln 
                725                 730                 735     


Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe 
            740                 745                 750         


Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser 
        755                 760                 765             


Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln 
    770                 775                 780                 


Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn 
785                 790                 795                 800 


Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu 
                805                 810                 815     


Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly Gly Ser Gly Gly 
            820                 825                 830         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Ser 
        835                 840                 845             


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
    850                 855                 860                 


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
865                 870                 875                 880 


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
                885                 890                 895     


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
            900                 905                 910         


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
        915                 920                 925             


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
    930                 935                 940                 


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
945                 950                 955                 960 


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
                965                 970                 975     


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
            980                 985                 990         


Ile Glu Leu Ile Gly Asn Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln 
        995                 1000                 1005             


Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys Ser 
    1010                 1015                 


<210>  418
<211>  1025
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  418

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
145                 150                 155                 160 


Ala Ser Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val 
                165                 170                 175     


Lys Leu His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro 
            180                 185                 190         


Trp Thr Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu 
        195                 200                 205             


Trp Arg Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg 
    210                 215                 220                 


Tyr Lys Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala 
225                 230                 235                 240 


Glu Pro Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp 
                245                 250                 255     


Ala Ser Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala 
            260                 265                 270         


Cys Met Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly 
        275                 280                 285             


Thr Met Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu 
    290                 295                 300                 


Arg Cys His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe 
305                 310                 315                 320 


Gln Tyr Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys 
                325                 330                 335     


Arg Val Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly 
            340                 345                 350         


Lys Thr Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser 
        355                 360                 365             


Leu Thr Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr 
    370                 375                 380                 


Phe Val His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys 
385                 390                 395                 400 


Asp Met Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg 
                405                 410                 415     


Tyr Val Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg 
            420                 425                 430         


Glu Pro Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser 
        435                 440                 445             


Val Ala Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly 
    450                 455                 460                 


Cys Val Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val 
465                 470                 475                 480 


Leu Lys Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met 
                485                 490                 495     


Gln Ser Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val 
            500                 505                 510         


Lys Met Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala 
        515                 520                 525             


Leu Arg Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly 
    530                 535                 540                 


Leu Ile Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His 
545                 550                 555                 560 


Pro Leu Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile 
                565                 570                 575     


Gly Ser His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln 
            580                 585                 590         


Gly Pro Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser 
        595                 600                 605             


Ala Leu Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu 
    610                 615                 620                 


Ser Gly Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr 
625                 630                 635                 640 


Arg Asp Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln 
                645                 650                 655     


Ala Ala Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu 
            660                 665                 670         


Glu Arg Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val 
        675                 680                 685             


Asp Arg Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr 
    690                 695                 700                 


Phe Ile Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu 
705                 710                 715                 720 


Ala Ser Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile 
                725                 730                 735     


Met Asn Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile 
            740                 745                 750         


Pro Lys Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys 
        755                 760                 765             


Gly Phe Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr 
    770                 775                 780                 


Thr Tyr Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn 
785                 790                 795                 800 


Tyr Phe Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr 
                805                 810                 815     


Asn Gly Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser 
            820                 825                 830         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        835                 840                 845             


Gly Gly Gly Ser Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile 
    850                 855                 860                 


Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn 
865                 870                 875                 880 


Leu Tyr Met Ser Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly 
                885                 890                 895     


Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala 
            900                 905                 910         


Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu 
        915                 920                 925             


Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile 
    930                 935                 940                 


Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn 
945                 950                 955                 960 


Asn Ile Val Asp His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn 
                965                 970                 975     


Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe 
            980                 985                 990         


Lys Asp Ile Leu Asp Lys Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly 
        995                 1000                 1005             


Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg 
    1010                 1015                 1020             


Lys Ser  
    1025 


<210>  419
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  419

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser Ser 
865                 870                 875                 880 


Gly Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Gly Glu Ser Gln Val 
                885                 890                 895     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            900                 905                 910         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        915                 920                 925             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    930                 935                 940                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
945                 950                 955                 960 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                965                 970                 975     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            980                 985                 990         


Gln His Ile Ser Glu Ser Ile Asn  Asn Ile Val Asp His  Ala Ile Lys 
        995                 1000                 1005             


Cys Lys  Asp His Ala Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala 
    1010                 1015                 1020             


Glu Gln  His Glu Glu Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys 
    1025                 1030                 1035             


Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp 
    1040                 1045                 1050             


Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg Lys Ser  
    1055                 1060                 1065 


<210>  420
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  420

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Cys 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser Ser 
865                 870                 875                 880 


Gly Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Gly Glu Ser Gln Val 
                885                 890                 895     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            900                 905                 910         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        915                 920                 925             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    930                 935                 940                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
945                 950                 955                 960 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                965                 970                 975     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            980                 985                 990         


Gln His Ile Ser Glu Ser Ile Asn  Asn Ile Val Asp His  Ala Ile Lys 
        995                 1000                 1005             


Ser Lys  Asp His Ala Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala 
    1010                 1015                 1020             


Glu Gln  His Glu Glu Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys 
    1025                 1030                 1035             


Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp 
    1040                 1045                 1050             


Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg Lys Ser  
    1055                 1060                 1065 


<210>  421
<211>  1366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  421

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Asp Ser Lys 
865                 870                 875                 880 


Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu Leu Val Val Ser 
                885                 890                 895     


Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Tyr Phe Leu Pro Pro Arg 
            900                 905                 910         


Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala Ile Thr Trp Val Pro 
        915                 920                 925             


Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro Pro Pro Pro Val Asn 
    930                 935                 940                 


Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp Lys Glu Val Lys Leu 
945                 950                 955                 960 


Pro His Trp Thr Pro Thr Leu His Thr Phe Gln Val Pro Gln Asn Tyr 
                965                 970                 975     


Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg Glu Tyr Thr Phe Ser 
            980                 985                 990         


Tyr Lys Gly Cys Cys Phe Tyr Phe  Thr Lys Lys Lys His  Thr Trp Asn 
        995                 1000                 1005             


Gly Cys  Phe Gln Ala Cys Ala  Glu Leu Tyr Pro Cys  Thr Tyr Phe 
    1010                 1015                 1020             


Tyr Gly  Pro Thr Pro Asp Ile  Leu Pro Val Val Thr  Arg Asn Leu 
    1025                 1030                 1035             


Asn Ala  Ile Glu Ser Leu Trp  Val Gly Val Tyr Arg  Val Gly Glu 
    1040                 1045                 1050             


Gly Asn  Trp Thr Ser Leu Asp  Gly Gly Thr Phe Lys  Val Tyr Gln 
    1055                 1060                 1065             


Ile Phe  Gly Ser His Cys Thr  Tyr Val Ser Lys Phe  Ser Thr Val 
    1070                 1075                 1080             


Pro Val  Ser His His Glu Cys  Ser Phe Leu Lys Pro  Cys Leu Cys 
    1085                 1090                 1095             


Val Ser  Gln Arg Ser Asn Ser  Gly Gly Ser Gly Ser  Ala Ser Ser 
    1100                 1105                 1110             


Gly Ala  Ser Ala Ser Gly Ser  Ser Gly Ser Gly Ser  Gly Ser Gly 
    1115                 1120                 1125             


Ser Ser  Ser Ala Ser Ser Gly  Ala Ser Ser Gly Gly  Ala Ser Gly 
    1130                 1135                 1140             


Gly Ser  Gly Gly Ser Gly Gly  Gly Ser Gly Ser Ala  Ser Ser Gly 
    1145                 1150                 1155             


Ala Ser  Ala Ser Gly Ser Ser  Gly Ser Gly Ser Gly  Ser Gly Ser 
    1160                 1165                 1170             


Ser Ser  Ala Ser Ser Gly Ala  Ser Ser Gly Gly Ala  Ser Gly Gly 
    1175                 1180                 1185             


Ser Gly  Gly Ser Gly Glu Ser  Gln Val Arg Gln Gln  Phe Ser Lys 
    1190                 1195                 1200             


Asp Ile  Glu Lys Leu Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln 
    1205                 1210                 1215             


Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser Trp Ser  Tyr Thr His 
    1220                 1225                 1230             


Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu 
    1235                 1240                 1245             


Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn 
    1250                 1255                 1260             


Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys 
    1265                 1270                 1275             


Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu 
    1280                 1285                 1290             


Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
    1295                 1300                 1305             


Lys Cys  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1310                 1315                 1320             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1325                 1330                 1335             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1340                 1345                 1350             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser 
    1355                 1360                 1365     


<210>  422
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  422

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Gly 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser Ser 
865                 870                 875                 880 


Gly Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Gly Glu Ser Gln Val 
                885                 890                 895     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            900                 905                 910         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        915                 920                 925             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    930                 935                 940                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
945                 950                 955                 960 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                965                 970                 975     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            980                 985                 990         


Gln His Ile Ser Glu Ser Ile Asn  Asn Ile Val Asp His  Ala Ile Lys 
        995                 1000                 1005             


Cys Lys  Asp His Ala Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala 
    1010                 1015                 1020             


Glu Gln  His Glu Glu Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys 
    1025                 1030                 1035             


Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp 
    1040                 1045                 1050             


Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg Lys Ser  
    1055                 1060                 1065 


<210>  423
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  423

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Ala 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Gly 
        835                 840                 845             


Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser Cys 
    850                 855                 860                 


Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly Ala Ser Ser 
865                 870                 875                 880 


Gly Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Gly Glu Ser Gln Val 
                885                 890                 895     


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
            900                 905                 910         


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
        915                 920                 925             


Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
    930                 935                 940                 


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
945                 950                 955                 960 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
                965                 970                 975     


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
            980                 985                 990         


Gln His Ile Ser Glu Ser Ile Asn  Asn Ile Val Asp His  Ala Ile Lys 
        995                 1000                 1005             


Ser Lys  Asp His Ala Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala 
    1010                 1015                 1020             


Glu Gln  His Glu Glu Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys 
    1025                 1030                 1035             


Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp 
    1040                 1045                 1050             


Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg Lys Ser  
    1055                 1060                 1065 


<210>  424
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  424

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Glu Ala 
            20                  25                  30          


Ala Leu Leu Val Cys Gln Tyr Thr Ile Gln Ser Leu Ile His Leu Thr 
        35                  40                  45              


Gly Glu Asp Pro Gly Phe Phe Asn Val Glu Ile Pro Glu Phe Pro Phe 
    50                  55                  60                  


Tyr Pro Thr Cys Asn Val Cys Thr Ala Asp Val Asn Val Thr Ile Asn 
65                  70                  75                  80  


Phe Asp Val Gly Gly Lys Lys His Gln Leu Asp Leu Asp Phe Gly Gln 
                85                  90                  95      


Leu Thr Pro His Thr Lys Ala Val Tyr Gln Pro Arg Gly Ala Phe Gly 
            100                 105                 110         


Gly Ser Glu Asn Ala Thr Asn Leu Phe Leu Leu Glu Leu Leu Gly Ala 
        115                 120                 125             


Gly Glu Leu Ala Leu Thr Met Arg Ser Lys Lys Leu Pro Ile Asn Val 
    130                 135                 140                 


Thr Thr Gly Glu Glu Gln Gln Val Ser Leu Glu Ser Val Asp Val Tyr 
145                 150                 155                 160 


Phe Gln Asp Val Phe Gly Thr Met Trp Cys His His Ala Glu Met Gln 
                165                 170                 175     


Asn Pro Val Tyr Leu Ile Pro Glu Thr Val Pro Tyr Ile Lys Trp Asp 
            180                 185                 190         


Asn Cys Asn Ser Thr Asn Ile Thr Ala Val Val Arg Ala Gln Gly Leu 
        195                 200                 205             


Asp Val Thr Leu Pro Leu Ser Leu Pro Thr Ser Ala Gln Asp Ser Asn 
    210                 215                 220                 


Phe Ser Val Lys Thr Glu Met Leu Gly Asn Glu Ile Asp Ile Glu Cys 
225                 230                 235                 240 


Ile Met Glu Asp Gly Glu Ile Ser Gln Val Leu Pro Gly Asp Asn Lys 
                245                 250                 255     


Phe Asn Ile Thr Cys Ser Gly Tyr Glu Ser His Val Pro Ser Gly Gly 
            260                 265                 270         


Ile Leu Thr Ser Thr Ser Pro Val Ala Thr Pro Ile Pro Gly Thr Gly 
        275                 280                 285             


Tyr Ala Tyr Ser Leu Arg Leu Thr Pro Arg Pro Val Ser Arg Phe Leu 
    290                 295                 300                 


Gly Asn Asn Ser Ile Leu Tyr Val Phe Tyr Ser Gly Asn Gly Pro Lys 
305                 310                 315                 320 


Ala Ser Gly Gly Asp Tyr Cys Ile Gln Ser Asn Ile Val Phe Ser Asp 
                325                 330                 335     


Glu Ile Pro Ala Ser Gln Asp Met Pro Thr Asn Thr Thr Asp Ile Thr 
            340                 345                 350         


Tyr Val Gly Asp Asn Ala Thr Tyr Ser Val Pro Met Val Thr Ser Glu 
        355                 360                 365             


Asp Ala Asn Ser Pro Asn Val Thr Val Thr Ala Phe Trp Ala Trp Pro 
    370                 375                 380                 


Asn Asn Thr Glu Thr Asp Phe Lys Cys Lys Trp Thr Leu Thr Ser Gly 
385                 390                 395                 400 


Thr Pro Ser Gly Cys Glu Asn Ile Ser Gly Ala Phe Ala Ser Asn Arg 
                405                 410                 415     


Thr Phe Asp Ile Thr Val Ser Gly Leu Gly Thr Ala Pro Lys Thr Leu 
            420                 425                 430         


Ile Ile Thr Arg Thr Ala Thr Asn Ala Thr Thr Thr Thr His Lys Val 
        435                 440                 445             


Ile Phe Ser Lys Ala Pro Glu Gly Ser Thr Gln Cys Asn Val Asn Pro 
    450                 455                 460                 


Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg Ser Cys Arg Asn 
465                 470                 475                 480 


Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser Leu Gln Tyr 
                485                 490                 495     


Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val Asn Arg Pro Gly 
            500                 505                 510         


Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg Glu His Ala 
        515                 520                 525             


Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu Thr Asn Asp 
    530                 535                 540                 


Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser Ser Trp Lys 
545                 550                 555                 560 


Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met Glu Ser Asp Val 
                565                 570                 575     


Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp Asp Ser Glu 
            580                 585                 590         


Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp Phe Leu Glu 
        595                 600                 605             


Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala Ser Thr Leu 
    610                 615                 620                 


Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe Ile Phe Asp 
625                 630                 635                 640 


Lys Lys Leu Leu Gly Ile Asp Val 
                645             


<210>  425
<211>  1039
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  425

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser 
        835                 840                 845             


Thr Gln Cys Asn Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr 
    850                 855                 860                 


Met His Arg Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu 
865                 870                 875                 880 


Val Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys 
                885                 890                 895     


Asp Val Val Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala 
            900                 905                 910         


Ser Glu Glu Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met 
        915                 920                 925             


Arg Gly Glu Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro 
    930                 935                 940                 


Pro Thr Arg Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala 
945                 950                 955                 960 


Leu Ser Met Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys 
                965                 970                 975     


Ala Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr 
            980                 985                 990         


Leu Thr Gly Asp Phe Leu Glu Glu  Gln Tyr Lys Gly Gln  Arg Asp Leu 
        995                 1000                 1005             


Ala Gly  Lys Ala Ser Thr Leu  Lys Lys Leu Met Asp  Arg His Glu 
    1010                 1015                 1020             


Ala Leu  Gly Glu Phe Ile Phe  Asp Lys Lys Leu Leu  Gly Ile Asp 
    1025                 1030                 1035             


Val 
    


<210>  426
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  426

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Glu Ala 
            20                  25                  30          


Ala Leu Leu Val Cys Gln Tyr Thr Ile Gln Ser Leu Ile His Leu Thr 
        35                  40                  45              


Gly Glu Asp Pro Gly Phe Phe Asn Val Glu Ile Pro Glu Phe Pro Phe 
    50                  55                  60                  


Tyr Pro Thr Cys Asn Val Cys Thr Ala Asp Val Asn Val Thr Ile Asn 
65                  70                  75                  80  


Phe Asp Val Gly Gly Lys Lys His Gln Leu Asp Leu Asp Phe Gly Gln 
                85                  90                  95      


Leu Thr Pro His Thr Lys Ala Val Tyr Gln Pro Arg Gly Ala Phe Gly 
            100                 105                 110         


Gly Ser Glu Asn Ala Thr Asn Leu Phe Leu Leu Glu Leu Leu Gly Ala 
        115                 120                 125             


Gly Glu Leu Ala Leu Thr Met Arg Ser Lys Lys Leu Pro Ile Asn Val 
    130                 135                 140                 


Thr Thr Gly Glu Glu Gln Gln Val Ser Leu Glu Ser Val Asp Val Tyr 
145                 150                 155                 160 


Phe Gln Asp Val Phe Gly Thr Met Trp Cys His His Ala Glu Met Gln 
                165                 170                 175     


Asn Pro Val Tyr Leu Ile Pro Glu Thr Val Pro Tyr Ile Lys Trp Asp 
            180                 185                 190         


Asn Cys Asn Ser Thr Asn Ile Thr Ala Val Val Arg Ala Gln Gly Leu 
        195                 200                 205             


Asp Val Thr Leu Pro Leu Ser Leu Pro Thr Ser Ala Gln Asp Ser Asn 
    210                 215                 220                 


Phe Ser Val Lys Thr Glu Met Leu Gly Asn Glu Ile Asp Ile Glu Cys 
225                 230                 235                 240 


Ile Met Glu Asp Gly Glu Ile Ser Gln Val Leu Pro Gly Asp Asn Lys 
                245                 250                 255     


Phe Asn Ile Thr Cys Ser Gly Tyr Glu Ser His Val Pro Ser Gly Gly 
            260                 265                 270         


Ile Leu Thr Ser Thr Ser Pro Val Ala Thr Pro Ile Pro Gly Thr Gly 
        275                 280                 285             


Tyr Ala Tyr Ser Leu Arg Leu Thr Pro Arg Pro Val Ser Arg Phe Leu 
    290                 295                 300                 


Gly Asn Asn Ser Ile Leu Tyr Val Phe Tyr Ser Gly Asn Gly Pro Lys 
305                 310                 315                 320 


Ala Ser Gly Gly Asp Tyr Cys Ile Gln Ser Asn Ile Val Phe Ser Asp 
                325                 330                 335     


Glu Ile Pro Ala Ser Gln Asp Met Pro Thr Asn Thr Thr Asp Ile Thr 
            340                 345                 350         


Tyr Val Gly Asp Asn Ala Thr Tyr Ser Val Pro Met Val Thr Ser Glu 
        355                 360                 365             


Asp Ala Asn Ser Pro Asn Val Thr Val Thr Ala Phe Trp Ala Trp Pro 
    370                 375                 380                 


Asn Asn Thr Glu Thr Asp Phe Lys Cys Lys Trp Thr Leu Thr Ser Gly 
385                 390                 395                 400 


Thr Pro Ser Gly Cys Glu Asn Ile Ser Gly Ala Phe Ala Ser Asn Arg 
                405                 410                 415     


Thr Phe Asp Ile Thr Val Ser Gly Leu Gly Thr Ala Pro Lys Thr Leu 
            420                 425                 430         


Ile Ile Thr Arg Thr Ala Thr Asn Ala Thr Thr Thr Thr His Lys Val 
        435                 440                 445             


Ile Phe Ser Lys Ala Pro Glu Gly Ser Ala Asp Thr Cys Tyr Asn Asp 
    450                 455                 460                 


Val Ala Leu Asp Cys Gly Ile Thr Ser Asn Ser Leu Ala Leu Pro Arg 
465                 470                 475                 480 


Cys Asn Ala Val Tyr Gly Glu Tyr Gly Ser His Gly Asn Val Ala Thr 
                485                 490                 495     


Glu Leu Gln Ala Tyr Ala Lys Leu His Leu Glu Arg Ser Tyr Asp Tyr 
            500                 505                 510         


Leu Leu Ser Ala Ala Tyr Phe Asn Asn Tyr Gln Thr Asn Arg Ala Gly 
        515                 520                 525             


Phe Ser Lys Leu Phe Lys Lys Leu Ser Asp Glu Ala Trp Ser Lys Thr 
    530                 535                 540                 


Ile Asp Ile Ile Lys His Val Thr Lys Arg Gly Asp Lys Met Asn Phe 
545                 550                 555                 560 


Asp Gln His Ser Thr Met Lys Thr Glu Arg Lys Asn Tyr Thr Ala Glu 
                565                 570                 575     


Asn His Glu Leu Glu Ala Leu Ala Lys Ala Leu Asp Thr Gln Lys Glu 
            580                 585                 590         


Leu Ala Glu Arg Ala Phe Tyr Ile His Arg Glu Ala Thr Arg Asn Ser 
        595                 600                 605             


Gln His Leu His Asp Pro Glu Ile Ala Gln Tyr Leu Glu Glu Glu Phe 
    610                 615                 620                 


Ile Glu Asp His Ala Glu Lys Ile Arg Thr Leu Ala Gly His Thr Ser 
625                 630                 635                 640 


Asp Leu Lys Lys Phe Ile Thr Ala Asn Asn Gly His Asp Leu Ser Leu 
                645                 650                 655     


Ala Leu Tyr Val Phe Asp Glu Tyr Leu Gln Lys Thr Val 
            660                 665                 


<210>  427
<211>  1060
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  427

Met Arg Ala Val Gly Val Phe Leu Ala Ile Cys Leu Val Thr Ile Phe 
1               5                   10                  15      


Val Leu Pro Thr Trp Gly Asn Trp Ala Tyr Pro Cys Cys His Val Thr 
            20                  25                  30          


Gln Leu Arg Ala Gln His Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile 
        35                  40                  45              


Tyr Leu Val Ser Asn Gln Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu 
    50                  55                  60                  


Asn Ser Pro Lys Asn Gly Ser Asn Gln Leu Val Ile Ser Arg Cys Ala 
65                  70                  75                  80  


Asn Gly Leu Asn Val Val Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser 
                85                  90                  95      


Ser Ser Ala Leu Thr Gly His Leu Arg Glu Leu Leu Thr Thr Leu Glu 
            100                 105                 110         


Thr Leu Tyr Gly Ser Phe Ser Val Glu Asp Leu Phe Gly Ala Asn Leu 
        115                 120                 125             


Asn Arg Tyr Ala Trp His Arg Gly Gly Gly Gly Ser Gly Ser Ala Ser 
    130                 135                 140                 


Ser Gly Ala Ser Ala Ser Gly Ser Ser Asn Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser Ser Gly Gly Ala Ser 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Ala Ala Ser Leu Ser Glu Val Lys Leu 
            180                 185                 190         


His Leu Asp Ile Glu Gly His Ala Ser His Tyr Thr Ile Pro Trp Thr 
        195                 200                 205             


Glu Leu Met Ala Lys Val Pro Gly Leu Ser Pro Glu Ala Leu Trp Arg 
    210                 215                 220                 


Glu Ala Asn Val Thr Glu Asp Leu Ala Ser Met Leu Asn Arg Tyr Lys 
225                 230                 235                 240 


Leu Ile Tyr Lys Thr Ser Gly Thr Leu Gly Ile Ala Leu Ala Glu Pro 
                245                 250                 255     


Val Asp Ile Pro Ala Val Ser Glu Gly Ser Met Gln Val Asp Ala Ser 
            260                 265                 270         


Lys Val His Pro Gly Val Ile Ser Gly Leu Asn Ser Pro Ala Cys Met 
        275                 280                 285             


Leu Ser Ala Pro Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met 
    290                 295                 300                 


Leu Pro Asn Thr Arg Pro His Ser Tyr Val Phe Tyr Gln Leu Arg Cys 
305                 310                 315                 320 


His Leu Ser Tyr Val Ala Leu Ser Ile Asn Gly Asp Lys Phe Gln Tyr 
                325                 330                 335     


Thr Gly Ala Met Thr Ser Lys Phe Leu Met Gly Thr Tyr Lys Arg Val 
            340                 345                 350         


Thr Glu Lys Gly Asp Glu His Val Leu Ser Leu Val Phe Gly Lys Thr 
        355                 360                 365             


Lys Asp Leu Pro Asp Leu Arg Gly Pro Phe Ser Tyr Pro Ser Leu Thr 
    370                 375                 380                 


Ser Ala Gln Ser Gly Asp Tyr Ser Leu Val Ile Val Thr Thr Phe Val 
385                 390                 395                 400 


His Tyr Ala Asn Phe His Asn Tyr Phe Val Pro Asn Leu Lys Asp Met 
                405                 410                 415     


Phe Ser Arg Ala Val Thr Met Thr Ala Ala Ser Tyr Ala Arg Tyr Val 
            420                 425                 430         


Leu Gln Lys Leu Val Leu Leu Glu Met Lys Gly Gly Cys Arg Glu Pro 
        435                 440                 445             


Glu Leu Asp Thr Glu Thr Leu Thr Thr Met Phe Glu Val Ser Val Ala 
    450                 455                 460                 


Phe Phe Lys Val Gly His Ala Val Gly Glu Thr Gly Asn Gly Cys Val 
465                 470                 475                 480 


Asp Leu Arg Trp Leu Ala Lys Ser Phe Phe Glu Leu Thr Val Leu Lys 
                485                 490                 495     


Asp Ile Ile Gly Ile Cys Tyr Gly Ala Thr Val Lys Gly Met Gln Ser 
            500                 505                 510         


Tyr Gly Leu Glu Arg Leu Ala Ala Met Leu Met Ala Thr Val Lys Met 
        515                 520                 525             


Glu Glu Leu Gly His Leu Thr Thr Glu Lys Gln Glu Tyr Ala Leu Arg 
    530                 535                 540                 


Leu Ala Thr Val Gly Tyr Pro Lys Ala Gly Val Tyr Ser Gly Leu Ile 
545                 550                 555                 560 


Gly Gly Ala Thr Ser Val Leu Leu Ser Ala Tyr Asn Arg His Pro Leu 
                565                 570                 575     


Phe Gln Pro Leu His Thr Val Met Arg Glu Thr Leu Phe Ile Gly Ser 
            580                 585                 590         


His Val Val Leu Arg Glu Leu Arg Leu Asn Val Thr Thr Gln Gly Pro 
        595                 600                 605             


Asn Leu Ala Leu Tyr Gln Leu Leu Ser Thr Ala Leu Cys Ser Ala Leu 
    610                 615                 620                 


Glu Ile Gly Glu Val Leu Arg Gly Leu Ala Leu Gly Thr Glu Ser Gly 
625                 630                 635                 640 


Leu Phe Ser Pro Cys Tyr Leu Ser Leu Arg Phe Asp Leu Thr Arg Asp 
                645                 650                 655     


Lys Leu Leu Ser Met Ala Pro Gln Glu Ala Thr Leu Asp Gln Ala Ala 
            660                 665                 670         


Val Ser Asn Ala Val Asp Gly Phe Leu Gly Arg Leu Ser Leu Glu Arg 
        675                 680                 685             


Glu Asp Arg Asp Ala Trp His Leu Pro Ala Tyr Lys Cys Val Asp Arg 
    690                 695                 700                 


Leu Asp Lys Val Leu Met Ile Ile Pro Leu Ile Asn Val Thr Phe Ile 
705                 710                 715                 720 


Ile Ser Ser Asp Arg Glu Val Arg Gly Ser Ala Leu Tyr Glu Ala Ser 
                725                 730                 735     


Thr Thr Tyr Leu Ser Ser Ser Leu Phe Leu Ser Pro Val Ile Met Asn 
            740                 745                 750         


Lys Cys Ser Gln Gly Ala Val Ala Gly Glu Pro Arg Gln Ile Pro Lys 
        755                 760                 765             


Ile Gln Asn Phe Thr Arg Thr Gln Lys Ser Cys Ile Phe Cys Gly Phe 
    770                 775                 780                 


Ala Leu Leu Ser Tyr Asp Glu Lys Glu Gly Leu Glu Thr Thr Thr Tyr 
785                 790                 795                 800 


Ile Thr Ser Gln Glu Val Gln Asn Ser Ile Leu Ser Ser Asn Tyr Phe 
                805                 810                 815     


Asp Phe Asp Asn Leu His Val His Tyr Leu Leu Leu Thr Thr Asn Gly 
            820                 825                 830         


Thr Val Met Glu Ile Ala Gly Leu Tyr Glu Glu Arg Ala Ser Gly Ser 
        835                 840                 845             


Ala Asp Thr Cys Tyr Asn Asp Val Ala Leu Asp Cys Gly Ile Thr Ser 
    850                 855                 860                 


Asn Ser Leu Ala Leu Pro Arg Cys Asn Ala Val Tyr Gly Glu Tyr Gly 
865                 870                 875                 880 


Ser His Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His 
                885                 890                 895     


Leu Glu Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn 
            900                 905                 910         


Tyr Gln Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser 
        915                 920                 925             


Asp Glu Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys 
    930                 935                 940                 


Arg Gly Asp Lys Met Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu 
945                 950                 955                 960 


Arg Lys Asn Tyr Thr Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys 
                965                 970                 975     


Ala Leu Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His 
            980                 985                 990         


Arg Glu Ala Thr Arg Asn Ser Gln  His Leu His Asp Pro  Glu Ile Ala 
        995                 1000                 1005             


Gln Tyr  Leu Glu Glu Glu Phe  Ile Glu Asp His Ala  Glu Lys Ile 
    1010                 1015                 1020             


Arg Thr  Leu Ala Gly His Thr  Ser Asp Leu Lys Lys  Phe Ile Thr 
    1025                 1030                 1035             


Ala Asn  Asn Gly His Asp Leu  Ser Leu Ala Leu Tyr  Val Phe Asp 
    1040                 1045                 1050             


Glu Tyr  Leu Gln Lys Thr Val  
    1055                 1060 


<210>  428
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  428

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


<210>  429
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  429

Gly Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
            20                  25              


<210>  430
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  430

Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser 
1               5                   10                  15      


Asn Gly Ser Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser Ser Gly 
            20                  25                  30          


Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
        35                  40                  45      


<210>  431
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  431

Gly Gly Ser Gly Ser Ala Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Ala Gly Gly Ser Gly Gly Ser Gly 
            20                  25      


<210>  432
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  432

Gly Gly Ser Gly Ser Ala Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Glu Ala Ala Ala Lys Ala Ser Gly Gly Ser Gly Gly Ser Gly 
            20                  25                  30          


<210>  433
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  433

Ser Gly Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly 
1               5                   10                  15      


Ser Ser Cys Ser Gly Ser Gly Ser Gly Ser Ser Ser Ala Ser Ser Gly 
            20                  25                  30          


Ala Ser Ser Gly Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Gly 
        35                  40                  45          


<210>  434
<211>  228
<212>  PRT
<213>  Epstein Barr Virus

<400>  434

Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu Leu 
1               5                   10                  15      


Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Tyr Phe Leu 
            20                  25                  30          


Pro Pro Arg Val Arg Gly Gly Gly Arg Val Ala Ala Ala Ala Ile Thr 
        35                  40                  45              


Trp Val Pro Lys Pro Asn Val Glu Val Trp Pro Val Asp Pro Pro Pro 
    50                  55                  60                  


Pro Val Asn Phe Asn Lys Thr Ala Glu Gln Glu Tyr Gly Asp Lys Glu 
65                  70                  75                  80  


Val Lys Leu Pro His Trp Thr Pro Thr Leu His Thr Phe Gln Val Pro 
                85                  90                  95      


Gln Asn Tyr Thr Lys Ala Asn Cys Thr Tyr Cys Asn Thr Arg Glu Tyr 
            100                 105                 110         


Thr Phe Ser Tyr Lys Gly Cys Cys Phe Tyr Phe Thr Lys Lys Lys His 
        115                 120                 125             


Thr Trp Asn Gly Cys Phe Gln Ala Cys Ala Glu Leu Tyr Pro Cys Thr 
    130                 135                 140                 


Tyr Phe Tyr Gly Pro Thr Pro Asp Ile Leu Pro Val Val Thr Arg Asn 
145                 150                 155                 160 


Leu Asn Ala Ile Glu Ser Leu Trp Val Gly Val Tyr Arg Val Gly Glu 
                165                 170                 175     


Gly Asn Trp Thr Ser Leu Asp Gly Gly Thr Phe Lys Val Tyr Gln Ile 
            180                 185                 190         


Phe Gly Ser His Cys Thr Tyr Val Ser Lys Phe Ser Thr Val Pro Val 
        195                 200                 205             


Ser His His Glu Cys Ser Phe Leu Lys Pro Cys Leu Cys Val Ser Gln 
    210                 215                 220                 


Arg Ser Asn Ser 
225             


<210>  435
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  435
tgactgtgaa cgttcgagat ga                                                22


<210>  436
<211>  115
<212>  PRT
<213>  Epstein Barr Virus

<400>  436

Asn Trp Ala Tyr Pro Cys Cys His Val Thr Gln Leu Arg Ala Gln His 
1               5                   10                  15      


Leu Leu Ala Leu Glu Asn Ile Ser Asp Ile Tyr Leu Val Ser Asn Gln 
            20                  25                  30          


Thr Cys Asp Gly Phe Ser Leu Ala Ser Leu Asn Ser Pro Lys Asn Gly 
        35                  40                  45              


Ser Asn Gln Leu Val Ile Ser Arg Cys Ala Asn Gly Leu Asn Val Val 
    50                  55                  60                  


Ser Phe Phe Ile Ser Ile Leu Lys Arg Ser Ser Ser Ala Leu Thr Gly 
65                  70                  75                  80  


His Leu Arg Glu Leu Leu Thr Thr Leu Glu Thr Leu Tyr Gly Ser Phe 
                85                  90                  95      


Ser Val Glu Asp Leu Phe Gly Ala Asn Leu Asn Arg Tyr Ala Trp His 
            100                 105                 110         


Arg Gly Gly 
        115 


<210>  437
<211>  662
<212>  PRT
<213>  Epstein Barr Virus

<400>  437

Ala Ala Ser Leu Ser Glu Val Lys Leu His Leu Asp Ile Glu Gly His 
1               5                   10                  15      


Ala Ser His Tyr Thr Ile Pro Trp Thr Glu Leu Met Ala Lys Val Pro 
            20                  25                  30          


Gly Leu Ser Pro Glu Ala Leu Trp Arg Glu Ala Asn Val Thr Glu Asp 
        35                  40                  45              


Leu Ala Ser Met Leu Asn Arg Tyr Lys Leu Ile Tyr Lys Thr Ser Gly 
    50                  55                  60                  


Thr Leu Gly Ile Ala Leu Ala Glu Pro Val Asp Ile Pro Ala Val Ser 
65                  70                  75                  80  


Glu Gly Ser Met Gln Val Asp Ala Ser Lys Val His Pro Gly Val Ile 
                85                  90                  95      


Ser Gly Leu Asn Ser Pro Ala Cys Met Leu Ser Ala Pro Leu Glu Lys 
            100                 105                 110         


Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr Arg Pro His 
        115                 120                 125             


Ser Tyr Val Phe Tyr Gln Leu Arg Cys His Leu Ser Tyr Val Ala Leu 
    130                 135                 140                 


Ser Ile Asn Gly Asp Lys Phe Gln Tyr Thr Gly Ala Met Thr Ser Lys 
145                 150                 155                 160 


Phe Leu Met Gly Thr Tyr Lys Arg Val Thr Glu Lys Gly Asp Glu His 
                165                 170                 175     


Val Leu Ser Leu Val Phe Gly Lys Thr Lys Asp Leu Pro Asp Leu Arg 
            180                 185                 190         


Gly Pro Phe Ser Tyr Pro Ser Leu Thr Ser Ala Gln Ser Gly Asp Tyr 
        195                 200                 205             


Ser Leu Val Ile Val Thr Thr Phe Val His Tyr Ala Asn Phe His Asn 
    210                 215                 220                 


Tyr Phe Val Pro Asn Leu Lys Asp Met Phe Ser Arg Ala Val Thr Met 
225                 230                 235                 240 


Thr Ala Ala Ser Tyr Ala Arg Tyr Val Leu Gln Lys Leu Val Leu Leu 
                245                 250                 255     


Glu Met Lys Gly Gly Cys Arg Glu Pro Glu Leu Asp Thr Glu Thr Leu 
            260                 265                 270         


Thr Thr Met Phe Glu Val Ser Val Ala Phe Phe Lys Val Gly His Ala 
        275                 280                 285             


Val Gly Glu Thr Gly Asn Gly Cys Val Asp Leu Arg Trp Leu Ala Lys 
    290                 295                 300                 


Ser Phe Phe Glu Leu Thr Val Leu Lys Asp Ile Ile Gly Ile Cys Tyr 
305                 310                 315                 320 


Gly Ala Thr Val Lys Gly Met Gln Ser Tyr Gly Leu Glu Arg Leu Ala 
                325                 330                 335     


Ala Met Leu Met Ala Thr Val Lys Met Glu Glu Leu Gly His Leu Thr 
            340                 345                 350         


Thr Glu Lys Gln Glu Tyr Ala Leu Arg Leu Ala Thr Val Gly Tyr Pro 
        355                 360                 365             


Lys Ala Gly Val Tyr Ser Gly Leu Ile Gly Gly Ala Thr Ser Val Leu 
    370                 375                 380                 


Leu Ser Ala Tyr Asn Arg His Pro Leu Phe Gln Pro Leu His Thr Val 
385                 390                 395                 400 


Met Arg Glu Thr Leu Phe Ile Gly Ser His Val Val Leu Arg Glu Leu 
                405                 410                 415     


Arg Leu Asn Val Thr Thr Gln Gly Pro Asn Leu Ala Leu Tyr Gln Leu 
            420                 425                 430         


Leu Ser Thr Ala Leu Cys Ser Ala Leu Glu Ile Gly Glu Val Leu Arg 
        435                 440                 445             


Gly Leu Ala Leu Gly Thr Glu Ser Gly Leu Phe Ser Pro Cys Tyr Leu 
    450                 455                 460                 


Ser Leu Arg Phe Asp Leu Thr Arg Asp Lys Leu Leu Ser Met Ala Pro 
465                 470                 475                 480 


Gln Glu Ala Thr Leu Asp Gln Ala Ala Val Ser Asn Ala Val Asp Gly 
                485                 490                 495     


Phe Leu Gly Arg Leu Ser Leu Glu Arg Glu Asp Arg Asp Ala Trp His 
            500                 505                 510         


Leu Pro Ala Tyr Lys Cys Val Asp Arg Leu Asp Lys Val Leu Met Ile 
        515                 520                 525             


Ile Pro Leu Ile Asn Val Thr Phe Ile Ile Ser Ser Asp Arg Glu Val 
    530                 535                 540                 


Arg Gly Ser Ala Leu Tyr Glu Ala Ser Thr Thr Tyr Leu Ser Ser Ser 
545                 550                 555                 560 


Leu Phe Leu Ser Pro Val Ile Met Asn Lys Cys Ser Gln Gly Ala Val 
                565                 570                 575     


Ala Gly Glu Pro Arg Gln Ile Pro Lys Ile Gln Asn Phe Thr Arg Thr 
            580                 585                 590         


Gln Lys Ser Cys Ile Phe Cys Gly Phe Ala Leu Leu Ser Tyr Asp Glu 
        595                 600                 605             


Lys Glu Gly Leu Glu Thr Thr Thr Tyr Ile Thr Ser Gln Glu Val Gln 
    610                 615                 620                 


Asn Ser Ile Leu Ser Ser Asn Tyr Phe Asp Phe Asp Asn Leu His Val 
625                 630                 635                 640 


His Tyr Leu Leu Leu Thr Thr Asn Gly Thr Val Met Glu Ile Ala Gly 
                645                 650                 655     


Leu Tyr Glu Glu Arg Ala 
            660         


<210>  438
<211>  425
<212>  PRT
<213>  Epstein Barr Virus

<400>  438

Glu Ala Ala Leu Leu Val Cys Gln Tyr Thr Ile Gln Ser Leu Ile His 
1               5                   10                  15      


Leu Thr Gly Glu Asp Pro Gly Phe Phe Asn Val Glu Ile Pro Glu Phe 
            20                  25                  30          


Pro Phe Tyr Pro Thr Cys Asn Val Cys Thr Ala Asp Val Asn Val Thr 
        35                  40                  45              


Ile Asn Phe Asp Val Gly Gly Lys Lys His Gln Leu Asp Leu Asp Phe 
    50                  55                  60                  


Gly Gln Leu Thr Pro His Thr Lys Ala Val Tyr Gln Pro Arg Gly Ala 
65                  70                  75                  80  


Phe Gly Gly Ser Glu Asn Ala Thr Asn Leu Phe Leu Leu Glu Leu Leu 
                85                  90                  95      


Gly Ala Gly Glu Leu Ala Leu Thr Met Arg Ser Lys Lys Leu Pro Ile 
            100                 105                 110         


Asn Val Thr Thr Gly Glu Glu Gln Gln Val Ser Leu Glu Ser Val Asp 
        115                 120                 125             


Val Tyr Phe Gln Asp Val Phe Gly Thr Met Trp Cys His His Ala Glu 
    130                 135                 140                 


Met Gln Asn Pro Val Tyr Leu Ile Pro Glu Thr Val Pro Tyr Ile Lys 
145                 150                 155                 160 


Trp Asp Asn Cys Asn Ser Thr Asn Ile Thr Ala Val Val Arg Ala Gln 
                165                 170                 175     


Gly Leu Asp Val Thr Leu Pro Leu Ser Leu Pro Thr Ser Ala Gln Asp 
            180                 185                 190         


Ser Asn Phe Ser Val Lys Thr Glu Met Leu Gly Asn Glu Ile Asp Ile 
        195                 200                 205             


Glu Cys Ile Met Glu Asp Gly Glu Ile Ser Gln Val Leu Pro Gly Asp 
    210                 215                 220                 


Asn Lys Phe Asn Ile Thr Cys Ser Gly Tyr Glu Ser His Val Pro Ser 
225                 230                 235                 240 


Gly Gly Ile Leu Thr Ser Thr Ser Pro Val Ala Thr Pro Ile Pro Gly 
                245                 250                 255     


Thr Gly Tyr Ala Tyr Ser Leu Arg Leu Thr Pro Arg Pro Val Ser Arg 
            260                 265                 270         


Phe Leu Gly Asn Asn Ser Ile Leu Tyr Val Phe Tyr Ser Gly Asn Gly 
        275                 280                 285             


Pro Lys Ala Ser Gly Gly Asp Tyr Cys Ile Gln Ser Asn Ile Val Phe 
    290                 295                 300                 


Ser Asp Glu Ile Pro Ala Ser Gln Asp Met Pro Thr Asn Thr Thr Asp 
305                 310                 315                 320 


Ile Thr Tyr Val Gly Asp Asn Ala Thr Tyr Ser Val Pro Met Val Thr 
                325                 330                 335     


Ser Glu Asp Ala Asn Ser Pro Asn Val Thr Val Thr Ala Phe Trp Ala 
            340                 345                 350         


Trp Pro Asn Asn Thr Glu Thr Asp Phe Lys Cys Lys Trp Thr Leu Thr 
        355                 360                 365             


Ser Gly Thr Pro Ser Gly Cys Glu Asn Ile Ser Gly Ala Phe Ala Ser 
    370                 375                 380                 


Asn Arg Thr Phe Asp Ile Thr Val Ser Gly Leu Gly Thr Ala Pro Lys 
385                 390                 395                 400 


Thr Leu Ile Ile Thr Arg Thr Ala Thr Asn Ala Thr Thr Thr Thr His 
                405                 410                 415     


Lys Val Ile Phe Ser Lys Ala Pro Glu 
            420                 425 


<210>  439
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  439

Cys Leu Val Pro Arg Gly Ser Leu Glu His His His His His His 
1               5                   10                  15  


<210>  440
<211>  154
<212>  PRT
<213>  Aquifex aeolicus

<400>  440

Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly 
1               5                   10                  15      


Ile Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu 
            20                  25                  30          


Gly Ala Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile 
        35                  40                  45              


Thr Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly 
    50                  55                  60                  


Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val 
65                  70                  75                  80  


Leu Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val 
                85                  90                  95      


Ser Lys Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr 
            100                 105                 110         


Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala 
        115                 120                 125             


Gly Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile 
    130                 135                 140                 


Glu Met Ala Asn Leu Phe Lys Ser Leu Arg 
145                 150                 


<210>  441
<211>  156
<212>  PRT
<213>  Escherichia coli

<400>  441

Met Asn Ile Ile Glu Ala Asn Val Ala Thr Pro Asp Ala Arg Val Ala 
1               5                   10                  15      


Ile Thr Ile Ala Arg Phe Asn Asn Phe Ile Asn Asp Ser Leu Leu Glu 
            20                  25                  30          


Gly Ala Ile Asp Ala Leu Lys Arg Ile Gly Gln Val Lys Asp Glu Asn 
        35                  40                  45              


Ile Thr Val Val Trp Val Pro Gly Ala Tyr Glu Leu Pro Leu Ala Ala 
    50                  55                  60                  


Gly Ala Leu Ala Lys Thr Gly Lys Tyr Asp Ala Val Ile Ala Leu Gly 
65                  70                  75                  80  


Thr Val Ile Arg Gly Gly Thr Ala His Phe Glu Tyr Val Ala Gly Gly 
                85                  90                  95      


Ala Ser Asn Gly Leu Ala His Val Ala Gln Asp Ser Glu Ile Pro Val 
            100                 105                 110         


Ala Phe Gly Val Leu Thr Thr Glu Ser Ile Glu Gln Ala Ile Glu Arg 
        115                 120                 125             


Ala Gly Thr Lys Ala Gly Asn Lys Gly Ala Glu Ala Ala Leu Thr Ala 
    130                 135                 140                 


Leu Glu Met Ile Asn Val Leu Lys Ala Ile Lys Ala 
145                 150                 155     


<210>  442
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6xHis tag

<400>  442

His His His His His His 
1               5       


<210>  443
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  443

Gly Gly Gly Ser 
1               


<210>  444
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  444

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  445
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  445

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  446

<400>  446
000

<210>  447

<400>  447
000

<210>  448

<400>  448
000

<210>  449

<400>  449
000

<210>  450

<400>  450
000

<210>  451

<400>  451
000

<210>  452

<400>  452
000

<210>  453

<400>  453
000

<210>  454

<400>  454
000

<210>  455

<400>  455
000

<210>  456

<400>  456
000

<210>  457

<400>  457
000

<210>  458

<400>  458
000

<210>  459

<400>  459
000

<210>  460

<400>  460
000

<210>  461

<400>  461
000

<210>  462

<400>  462
000

<210>  463

<400>  463
000

<210>  464

<400>  464
000

<210>  465

<400>  465
000

<210>  466

<400>  466
000

<210>  467

<400>  467
000

<210>  468

<400>  468
000

<210>  469

<400>  469
000

<210>  470

<400>  470
000

<210>  471

<400>  471
000

<210>  472

<400>  472
000

<210>  473

<400>  473
000

<210>  474

<400>  474
000

<210>  475

<400>  475
000

<210>  476

<400>  476
000

<210>  477

<400>  477
000

<210>  478

<400>  478
000

<210>  479

<400>  479
000

<210>  480

<400>  480
000

<210>  481

<400>  481
000

<210>  482

<400>  482
000

<210>  483

<400>  483
000

<210>  484

<400>  484
000

<210>  485

<400>  485
000

<210>  486

<400>  486
000

<210>  487

<400>  487
000

<210>  488

<400>  488
000

<210>  489

<400>  489
000

<210>  490

<400>  490
000

<210>  491

<400>  491
000

<210>  492

<400>  492
000

<210>  493

<400>  493
000

<210>  494

<400>  494
000

<210>  495

<400>  495
000

<210>  496

<400>  496
000

<210>  497

<400>  497
000

<210>  498

<400>  498
000

<210>  499

<400>  499
000

<210>  500

<400>  500
000

<210>  501
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  501

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  502
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  502

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  503
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  503

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Asn Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  504
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  504

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Asn 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  505
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  505

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Thr Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  506
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  506

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Asn Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  507
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  507

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Ser Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  508
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  508

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Asn Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  509
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  509

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Pro Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  510
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  510

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Pro Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Leu Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  511
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  511

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Pro Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  512
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  512

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Ile Glu Thr Val Ile Glu Phe Leu Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  513
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  513

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Ile Glu Thr Val Ile Glu Phe Leu Val Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  514
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  514

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Leu Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  515
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  515

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Phe Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  516
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  516

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Pro Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Cys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  517
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  517

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Pro Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Asn 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Asn Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Asn Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Cys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  518
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  518

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Pro Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Asn 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Asn Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Leu Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Asn Gln Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Cys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  519
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  519

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Val Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Val Ser Ile Ser Asn 
                165                 170                 175     


Pro Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Asn 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Asn Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Asn Lys Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Cys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  520
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  520

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Pro Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Asn 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Asn Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Leu Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Asn Gln Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Asn Asp Ile Glu Asn Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Cys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  521
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  521

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Pro Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Asn 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Asn Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Asn Ser Leu Tyr Val Asn Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Leu Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Asn Gln Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Cys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  522
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  522

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Pro Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Asn 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Asn Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Asn Ser Leu Tyr Val Asn Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Leu Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Asn Gln Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Arg Gln Gln Phe Ser Asn Asp Ile Glu Asn Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Cys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  523
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  523

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gly Ser Gly Asn Val Gly Leu Gly Gly Ala Ile Ala Ser Gly Val 
            100                 105                 110         


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
        115                 120                 125             


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
    130                 135                 140                 


Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
145                 150                 155                 160 


Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser Asn 
                165                 170                 175     


Pro Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
            180                 185                 190         


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
        195                 200                 205             


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
    210                 215                 220                 


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile 
225                 230                 235                 240 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
                245                 250                 255     


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
            260                 265                 270         


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Asn 
        275                 280                 285             


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
    290                 295                 300                 


Asn Ala Gly Asn Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
305                 310                 315                 320 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu Pro 
                325                 330                 335     


Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp 
            340                 345                 350         


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
        355                 360                 365             


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
    370                 375                 380                 


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
385                 390                 395                 400 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
                405                 410                 415     


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
            420                 425                 430         


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 
        435                 440                 445             


Asp Ala Ser Ile Ser Gln Val Asn Glu Leu Ile Asn Gln Ser Leu Ala 
    450                 455                 460                 


Phe Ile Asn Gln Ser Asp Glu Leu Leu Ser Gly Ser Gly Ser Glu Ser 
465                 470                 475                 480 


Gln Val Gln Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
                485                 490                 495     


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
            500                 505                 510         


Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        515                 520                 525             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    530                 535                 540                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
545                 550                 555                 560 


Glu His Cys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                565                 570                 575     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            580                 585                 590         


Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        595                 600                 605             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    610                 615                 620                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
625                 630                 635                 640 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                645                 650     


<210>  524
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  524

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Ala Ile Ala Ser Gly Val Ala Val 
    130                 135                 140                 


Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser Ala 
145                 150                 155                 160 


Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser 
                165                 170                 175     


Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln 
            180                 185                 190         


Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu 
        195                 200                 205             


Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr 
    210                 215                 220                 


Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser Thr Tyr 
225                 230                 235                 240 


Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile 
                245                 250                 255     


Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile Val Arg 
            260                 265                 270         


Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val Leu Ala 
        275                 280                 285             


Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp 
    290                 295                 300                 


Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser 
305                 310                 315                 320 


Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala 
                325                 330                 335     


Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val Gln Ser 
            340                 345                 350         


Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr Leu Pro Ser Glu 
        355                 360                 365             


Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys 
    370                 375                 380                 


Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr Ser Leu 
385                 390                 395                 400 


Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn 
                405                 410                 415     


Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val 
            420                 425                 430         


Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr 
        435                 440                 445             


Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile 
    450                 455                 460                 


Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala 
465                 470                 475                 480 


Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile 
                485                 490                 495     


Arg Lys Ser Asp Glu Leu Leu Gly Leu Glu Val Leu Phe Gln Gly Pro 
            500                 505                 510         


His His His His His His His His Ser Ala Trp Ser His Pro Gln Phe 
        515                 520                 525             


Glu Lys 
    530 


<210>  525
<211>  689
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  525

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu Ser Gly Gly Ser Ser Gly Ser Ser Gly Gly Ser Asp Ile Ile Lys 
        515                 520                 525             


Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr 
    530                 535                 540                 


Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly 
545                 550                 555                 560 


Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys 
                565                 570                 575     


Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser 
            580                 585                 590         


Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln 
        595                 600                 605             


Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile 
    610                 615                 620                 


Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu 
625                 630                 635                 640 


Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp 
                645                 650                 655     


Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr 
            660                 665                 670         


Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly 
        675                 680                 685             


Ser 
    


<210>  526
<211>  574
<212>  PRT
<213>  Human respiratory syncytial virus

<400>  526

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Pro Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Ile Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Met Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 


<210>  527
<211>  297
<212>  PRT
<213>  Human respiratory syncytial virus

<400>  527

Met Ser Lys Asn Lys Asp Gln Arg Thr Ala Lys Thr Leu Glu Arg Thr 
1               5                   10                  15      


Trp Asp Thr Leu Asn His Leu Leu Phe Ile Ser Ser Cys Leu Tyr Lys 
            20                  25                  30          


Leu Asn Leu Lys Ser Val Ala Gln Ile Thr Leu Ser Ile Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Val Ala Ile Ile Phe Ile Ala Ser 
    50                  55                  60                  


Ala Asn His Lys Ile Thr Ser Thr Thr Thr Ile Ile Gln Asp Ala Thr 
65                  70                  75                  80  


Asn Gln Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asn Pro Gln 
                85                  90                  95      


Leu Gly Ile Ser Pro Ser Asn Pro Ser Asp Ile Thr Ser Leu Ile Thr 
            100                 105                 110         


Thr Ile Leu Asp Ser Thr Thr Pro Gly Val Lys Ser Thr Leu Gln Ser 
        115                 120                 125             


Thr Thr Val Gly Thr Lys Asn Thr Thr Thr Thr Gln Ala Gln Pro Asn 
    130                 135                 140                 


Lys Pro Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Ser Lys Pro Asn 
145                 150                 155                 160 


Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys 
            180                 185                 190         


Lys Pro Gly Lys Arg Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Pro 
        195                 200                 205             


Lys Thr Thr Lys Lys Gly Pro Lys Pro Gln Thr Thr Lys Ser Lys Glu 
    210                 215                 220                 


Ala Pro Thr Thr Lys Pro Thr Glu Glu Pro Thr Ile Asn Thr Thr Lys 
225                 230                 235                 240 


Thr Asn Ile Ile Thr Thr Leu Leu Thr Ser Asn Thr Thr Arg Asn Pro 
                245                 250                 255     


Glu Leu Thr Ser Gln Met Glu Thr Phe His Ser Thr Ser Ser Glu Gly 
            260                 265                 270         


Asn Pro Ser Pro Ser Gln Val Ser Ile Thr Ser Glu Tyr Pro Ser Gln 
        275                 280                 285             


Pro Ser Ser Pro Pro Asn Thr Pro Arg 
    290                 295         


<210>  528
<211>  233
<212>  PRT
<213>  Human respiratory syncytial virus

<400>  528

Asn His Lys Val Thr Leu Thr Thr Ala Ile Ile Gln Asp Ala Thr Ser 
1               5                   10                  15      


Gln Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asp Pro Gln Leu 
            20                  25                  30          


Gly Ile Ser Phe Ser Asn Leu Ser Glu Ile Thr Ser Gln Thr Thr Thr 
        35                  40                  45              


Ile Leu Ala Ser Thr Thr Pro Gly Val Lys Ser Asn Leu Gln Pro Thr 
    50                  55                  60                  


Thr Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Thr Gln Pro Ser Lys 
65                  70                  75                  80  


Pro Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn Asn 
                85                  90                  95      


Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys Ser 
            100                 105                 110         


Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys Lys 
        115                 120                 125             


Pro Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Phe Lys 
    130                 135                 140                 


Thr Thr Lys Lys Asp His Lys Pro Gln Thr Thr Lys Pro Lys Glu Val 
145                 150                 155                 160 


Pro Thr Thr Lys Pro Thr Glu Glu Pro Thr Ile Asn Thr Thr Lys Thr 
                165                 170                 175     


Asn Ile Ile Thr Thr Leu Leu Thr Asn Asn Thr Thr Gly Asn Pro Lys 
            180                 185                 190         


Leu Thr Ser Gln Met Glu Thr Phe His Ser Thr Ser Ser Glu Gly Asn 
        195                 200                 205             


Leu Ser Pro Ser Gln Val Ser Thr Thr Ser Glu His Pro Ser Gln Pro 
    210                 215                 220                 


Ser Ser Pro Pro Asn Thr Thr Arg Gln 
225                 230             


<210>  529
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  529

Ser Gly Gly Ser Ser Gly Ser Ser Glu Glu Glu Gly Gly Ser Arg Gln 
1               5                   10                  15      


Asn Lys Pro Asn Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro 
            20                  25                  30          


Cys Ser Ile Cys Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg 
        35                  40                  45              


Ile Pro Asn Lys Lys Glu Glu Glu 
    50                  55      


<210>  530
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  530
tgactgtgaa cgttcgagat ga                                                22


<210>  531
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  531

Gly Ser Gly Asn Val Gly Leu 
1               5           


<210>  532
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Monobasic mutation sequence

<400>  532

Pro Gln Arg Glu Thr 
1               5   


<210>  533
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  533

Ser Gly Ser Gly Ser 
1               5   


<210>  534
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  534
tgactgtgaa cgttcgagat g                                                 21


<210>  535
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  535
tccatgacgt tcctgacgtt                                                   20


<210>  536
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  536

Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn Asn Asp Phe His Phe Glu 
1               5                   10                  15      


Val Phe Asn Phe Val Pro Cys Ser Ile Cys Ser Asn Asn Pro Thr Cys 
            20                  25                  30          


Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys Lys 
        35                  40              


<210>  537
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  537

Arg Lys Asn Pro Pro Lys Lys Pro Lys Asp Asp Tyr His Phe Glu Val 
1               5                   10                  15      


Phe Asn Phe Val Pro Cys Ser Ile Cys Gly Asn Asn Gln Leu Cys Lys 
            20                  25                  30          


Ser Ile Cys Lys Thr Ile Pro Asn Lys Lys 
        35                  40          


