                         SEQUENCE LISTING

<110>  NightstaRx Limited
       Oxford University Innovation Limited
 
<120>  COMPOSITIONS AND METHODS FOR TREATING MACULAR DYSTROPHY

<130>  NIGH-011/002WO

<150>  US 62/653,131
<151>  2018-04-05

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  623
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  1
aattctgtca ttttactagg gtgatgaaat tcccaagcaa caccatcctt ttcagataag       60

ggcactgagg ctgagagagg agctgaaacc tacccggggt caccacacac aggtggcaag      120

gctgggacca gaaaccagga ctgttgactg cagcccggta ttcattcttt ccatagccca      180

cagggctgtc aaagacccca gggcctagtc agaggctcct ccttcctgga gagttcctgg      240

cacagaagtt gaagctcagc acagccccct aacccccaac tctctctgca aggcctcagg      300

ggtcagaaca ctggtggagc agatccttta gcctctggat tttagggcca tggtagaggg      360

ggtgttgccc taaattccag ccctggtctc agcccaacac cctccaagaa gaaattagag      420

gggccatggc caggctgtgc tagccgttgc ttctgagcag attacaagaa gggactaaga      480

caaggactcc tttgtggagg tcctggctta gggagtcaag tgacggcggc tcagcactca      540

cgtgggcagt gccagcctct aagagtgggc aggggcactg gccacagagt cccagggagt      600

cccaccagcc tagtcgccag acc                                              623


<210>  2
<211>  941
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  2
ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga       60

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat      120

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc      180

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct      240

attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc      300

ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg      360

gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg      420

cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg      480

aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg agtcgctgcg      540

cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga      600

ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat      660

tagcgcttgg tttaatgacg gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg      720

ctccgggagg gccctttgtg cggggggagc ggctcggggc tgtccgcggg gggacggctg      780

ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctctag      840

agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct      900

ggttattgtg ctgtctcatc attttggcaa agaattggat c                          941


<210>  3
<211>  1758
<212>  DNA
<213>  Homo sapiens

<400>  3
atgaccatca cttacacaag ccaagtggct aatgcccgct taggctcctt ctcccgcctg       60

ctgctgtgct ggcggggcag catctacaag ctgctatatg gcgagttctt aatcttcctg      120

ctctgctact acatcatccg ctttatttat aggctggccc tcacggaaga acaacagctg      180

atgtttgaga aactgactct gtattgcgac agctacatcc agctcatccc catttccttc      240

gtgctgggct tctacgtgac gctggtcgtg acccgctggt ggaaccagta cgagaacctg      300

ccgtggcccg accgcctcat gagcctggtg tcgggcttcg tcgaaggcaa ggacgagcaa      360

ggccggctgc tgcggcgcac gctcatccgc tacgccaacc tgggcaacgt gctcatcctg      420

cgcagcgtca gcaccgcagt ctacaagcgc ttccccagcg cccagcacct ggtgcaagca      480

ggctttatga ctccggcaga acacaagcag ttggagaaac tgagcctacc acacaacatg      540

ttctgggtgc cctgggtgtg gtttgccaac ctgtcaatga aggcgtggct tggaggtcga      600

atccgggacc ctatcctgct ccagagcctg ctgaacgaga tgaacacctt gcgtactcag      660

tgtggacacc tgtatgccta cgactggatt agtatcccac tggtgtatac acaggtggtg      720

actgtggcgg tgtacagctt cttcctgact tgtctagttg ggcggcagtt tctgaaccca      780

gccaaggcct accctggcca tgagctggac ctcgttgtgc ccgtcttcac gttcctgcag      840

ttcttcttct atgttggctg gctgaaggtg gcagagcagc tcatcaaccc ctttggagag      900

gatgatgatg attttgagac caactggatt gtcgacagga atttgcaggt gtccctgttg      960

gctgtggatg agatgcacca ggacctgcct cggatggagc cggacatgta ctggaataag     1020

cccgagccac agccccccta cacagctgct tccgcccagt tccgtcgagc ctcctttatg     1080

ggctccacct tcaacatcag cctgaacaaa gaggagatgg agttccagcc caatcaggag     1140

gacgaggagg atgctcacgc tggcatcatt ggccgcttcc taggcctgca gtcccatgat     1200

caccatcctc ccagggcaaa ctcaaggacc aaactactgt ggcccaagag ggaatccctt     1260

ctccacgagg gcctgcccaa aaaccacaag gcagccaaac agaacgttag gggccaggaa     1320

gacaacaagg cctggaagct taaggctgtg gacgccttca agtctgcccc actgtatcag     1380

aggccaggct actacagtgc cccacagacg cccctcagcc ccactcccat gttcttcccc     1440

ctagaaccat cagcgccgtc aaagcttcac agtgtcacag gcatagacac caaagacaaa     1500

agcttaaaga ctgtgagttc tggggccaag aaaagttttg aattgctctc agagagcgat     1560

ggggccttga tggagcaccc agaagtatct caagtgagga ggaaaactgt ggagtttaac     1620

ctgacggata tgccagagat ccccgaaaat cacctcaaag aacctttgga acaatcacca     1680

accaacatac acactacact caaagatcac atggatcctt attgggcctt ggaaaacagg     1740

gatgaagcac attcctaa                                                   1758


<210>  4
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Ile Thr Tyr Thr Ser Gln Val Ala Asn Ala Arg Leu Gly Ser 
1               5                   10                  15      


Phe Ser Arg Leu Leu Leu Cys Trp Arg Gly Ser Ile Tyr Lys Leu Leu 
            20                  25                  30          


Tyr Gly Glu Phe Leu Ile Phe Leu Leu Cys Tyr Tyr Ile Ile Arg Phe 
        35                  40                  45              


Ile Tyr Arg Leu Ala Leu Thr Glu Glu Gln Gln Leu Met Phe Glu Lys 
    50                  55                  60                  


Leu Thr Leu Tyr Cys Asp Ser Tyr Ile Gln Leu Ile Pro Ile Ser Phe 
65                  70                  75                  80  


Val Leu Gly Phe Tyr Val Thr Leu Val Val Thr Arg Trp Trp Asn Gln 
                85                  90                  95      


Tyr Glu Asn Leu Pro Trp Pro Asp Arg Leu Met Ser Leu Val Ser Gly 
            100                 105                 110         


Phe Val Glu Gly Lys Asp Glu Gln Gly Arg Leu Leu Arg Arg Thr Leu 
        115                 120                 125             


Ile Arg Tyr Ala Asn Leu Gly Asn Val Leu Ile Leu Arg Ser Val Ser 
    130                 135                 140                 


Thr Ala Val Tyr Lys Arg Phe Pro Ser Ala Gln His Leu Val Gln Ala 
145                 150                 155                 160 


Gly Phe Met Thr Pro Ala Glu His Lys Gln Leu Glu Lys Leu Ser Leu 
                165                 170                 175     


Pro His Asn Met Phe Trp Val Pro Trp Val Trp Phe Ala Asn Leu Ser 
            180                 185                 190         


Met Lys Ala Trp Leu Gly Gly Arg Ile Arg Asp Pro Ile Leu Leu Gln 
        195                 200                 205             


Ser Leu Leu Asn Glu Met Asn Thr Leu Arg Thr Gln Cys Gly His Leu 
    210                 215                 220                 


Tyr Ala Tyr Asp Trp Ile Ser Ile Pro Leu Val Tyr Thr Gln Val Val 
225                 230                 235                 240 


Thr Val Ala Val Tyr Ser Phe Phe Leu Thr Cys Leu Val Gly Arg Gln 
                245                 250                 255     


Phe Leu Asn Pro Ala Lys Ala Tyr Pro Gly His Glu Leu Asp Leu Val 
            260                 265                 270         


Val Pro Val Phe Thr Phe Leu Gln Phe Phe Phe Tyr Val Gly Trp Leu 
        275                 280                 285             


Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp 
    290                 295                 300                 


Phe Glu Thr Asn Trp Ile Val Asp Arg Asn Leu Gln Val Ser Leu Leu 
305                 310                 315                 320 


Ala Val Asp Glu Met His Gln Asp Leu Pro Arg Met Glu Pro Asp Met 
                325                 330                 335     


Tyr Trp Asn Lys Pro Glu Pro Gln Pro Pro Tyr Thr Ala Ala Ser Ala 
            340                 345                 350         


Gln Phe Arg Arg Ala Ser Phe Met Gly Ser Thr Phe Asn Ile Ser Leu 
        355                 360                 365             


Asn Lys Glu Glu Met Glu Phe Gln Pro Asn Gln Glu Asp Glu Glu Asp 
    370                 375                 380                 


Ala His Ala Gly Ile Ile Gly Arg Phe Leu Gly Leu Gln Ser His Asp 
385                 390                 395                 400 


His His Pro Pro Arg Ala Asn Ser Arg Thr Lys Leu Leu Trp Pro Lys 
                405                 410                 415     


Arg Glu Ser Leu Leu His Glu Gly Leu Pro Lys Asn His Lys Ala Ala 
            420                 425                 430         


Lys Gln Asn Val Arg Gly Gln Glu Asp Asn Lys Ala Trp Lys Leu Lys 
        435                 440                 445             


Ala Val Asp Ala Phe Lys Ser Ala Pro Leu Tyr Gln Arg Pro Gly Tyr 
    450                 455                 460                 


Tyr Ser Ala Pro Gln Thr Pro Leu Ser Pro Thr Pro Met Phe Phe Pro 
465                 470                 475                 480 


Leu Glu Pro Ser Ala Pro Ser Lys Leu His Ser Val Thr Gly Ile Asp 
                485                 490                 495     


Thr Lys Asp Lys Ser Leu Lys Thr Val Ser Ser Gly Ala Lys Lys Ser 
            500                 505                 510         


Phe Glu Leu Leu Ser Glu Ser Asp Gly Ala Leu Met Glu His Pro Glu 
        515                 520                 525             


Val Ser Gln Val Arg Arg Lys Thr Val Glu Phe Asn Leu Thr Asp Met 
    530                 535                 540                 


Pro Glu Ile Pro Glu Asn His Leu Lys Glu Pro Leu Glu Gln Ser Pro 
545                 550                 555                 560 


Thr Asn Ile His Thr Thr Leu Lys Asp His Met Asp Pro Tyr Trp Ala 
                565                 570                 575     


Leu Glu Asn Arg Asp Glu Ala His Ser 
            580                 585 


<210>  5

<400>  5
000

<210>  6
<211>  53
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  6
ctcctgggca acgtgctggt tattgtgctg tctcatcatt ttggcaaaga att              53


<210>  7
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  7
gtgccgcagg gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg       60

cgtgtgaccg gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta      120

cag                                                                    123


<210>  8
<211>  593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  8
atcgataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat       60

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct      120

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag      180

gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc      240

cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc      300

ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct      360

cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg      420

ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg      480

gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg      540

cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc ccc             593


<210>  9
<211>  269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  9
cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc       60

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa      120

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac      180

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg      240

gcttctgagg cggaaagaac cagctgggg                                        269


<210>  10
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  10
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gatt                                             144


<210>  11
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  11
tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg       60

cccgggcggc ctcagtgagc gagcgagcgc gcagagcttt ttgcaaaagc ctaggcctcc      120

aaaaaagcct cctcactact tctgg                                            145


<210>  12
<211>  2500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  12
gatgtaacca tatacttagg ctggatcttc tcccgcgaat tttaaccctc accaactacg       60

agatatgagg taagccaaaa aagcacgtag tggcgctctc cgactgttcc caaattgtaa      120

cttatcgttc cgtgaaggcc agagttactt cccggccctt tccatgcgcg caccataccc      180

tcctagttcc ccggttatct ttccgaagtg ggagtgagcg aacctccgtt tacgtcttgt      240

taccaatgat gtagctatgc actttgtaca gggtgccaac gggtttcaca attcacagat      300

agtggggatc ccggcaaagg gcctatattt gcggtccaac ttaggcgtaa acctcgatgc      360

tacctactca gacccacctc gcgcggggta aataaggcac tcatcccagc tggttcttgg      420

cgttctacgc agcgacatgt ttattaacag ttgtctggca gcacaaaact tttaccatgg      480

tcgtagaagc cccccagagt tagttcatac ctaatgccac aaatgtgaca ggacgccgat      540

gggtaccgga ctttaggtcg agcacagttc ggtaacggag agaccctgcg gcgtacttca      600

ttatgtatat ggaacgtgcc caagtgacgc caggcaagtc tcagctggtt cctgtgttag      660

ctcgagggta gacatacgag ctgattgaac atgggttggg ggcctcgaac cgtcgaggac      720

cccatagtac ctcggagacc aagtagggca gcctatagtt tgaagcagaa ctatttcggg      780

gggcgagccc tcatcgtctc ttctgcggat gactcaacac gctagggacg tgaagtcgat      840

tccttcgatg gttataaatc aaagactcag agtgctgtct ggagcgtgaa tctaacggta      900

cgtatctcga ttgctcggtc gcttttcgca ctccgcgaaa gttcgtaccg ctcattcact      960

aggttgcgaa gcctatgctg atatatgaat ccaaactaga gcagggctct taagattcgg     1020

agttgtaaat acttaatact ccaatcggct tttacgtgca ccaccgcggg cggctgacaa     1080

gggtctcaca tcgagaaaca agacagttcc gggctggaag tagcgccggc taaggaagac     1140

gcctggtacg gcaggactat gaaaccagta caaaggcaac atcctcactt gggtgaacgg     1200

aaacgcagta ttatggttac tttttggata cgtgaaacat atcccatggt agtccttaga     1260

cttgggagtc tatcacccct agggcccata tctggaaata gacgccaggt tgaatccgta     1320

tttggaggta cgatggaaca gtctgggtgg gacgtgcttc atttataccc tgcgcaggct     1380

ggaccgagga ccgcaaggtg cggcggtgca caagcaattg acaactaacc accgtgtatt     1440

cattatggta ccaggaactt taagccgagt caatgaagct cgcattacag tgtttaccgc     1500

atcttgccgt tactcacaaa ctgtgatcca ccacaagtca agccattgcc tctctgacac     1560

gccgtaagaa ttaatatgta aactttgcgc gggttgactg cgatccgttc agtctcgtcc     1620

gagggcacaa tcctattccc atttgtatgt tcagctaact tctacccatc ccccgaagtt     1680

aagtaggtcg tgagatgcca tggaggctct cgttcatccc gtgggacatc aagcttcccc     1740

ttgataaagc accccgctcg ggtgtagcag agaagacgcc ttctgaattg tgcaatccct     1800

ccaccttatc taagcttgct accaataatt agcatttttg ccttgcgaca gacctcctac     1860

ttagattgcc acacattgag ctagtcagtg agcgataagc ttgacgcgct ttcaagggtc     1920

gcgagtacgt gaactaaggc tccggacagg actatatact tgggtttgat ctcgccccga     1980

caactgcaaa cctcaacttt tttagattat atggttagcc gaagttgcac gaggtggcgt     2040

ccgcggactg ctccccgagt gtggctcttt catctgacaa cgtgcaaccc ctatcgcggc     2100

cgattgtttc tgcggacgat gttgtcctca tagtttgggc atgtttccct tgtaggtgtg     2160

aaaccactta gcttcgcgcc gtagtcccaa tgaaaaacct atggactttg ttttgggtag     2220

caccaggaat ctgaaccgtg tgaatgtgga cgtcgcgcgc gtagaccttt atctccggtt     2280

caagctaggg atgtggctgc atgctacgtt gtcacaccta cactgctcga agtaaatatg     2340

cgaagcgcgc ggcctggccg gaggcgttcc gcgccgccac gtgttcgtta actgttgatt     2400

ggtggcacat aagcaatatc gtagtccgtc aaattcagct ctgttatccc gggcgttatg     2460

tgtcaaatgg cgtagaacgg gattgactgt ttgacggtag                           2500


<210>  13
<211>  8938
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  13
tagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctaggtaaa ttctgtcatt ttactagggt gatgaaattc ccaagcaaca ccatcctttt      240

cagataaggg cactgaggct gagagaggag ctgaaaccta cccggggtca ccacacacag      300

gtggcaaggc tgggaccaga aaccaggact gttgactgca gcccggtatt cattctttcc      360

atagcccaca gggctgtcaa agaccccagg gcctagtcag aggctcctcc ttcctggaga      420

gttcctggca cagaagttga agctcagcac agccccctaa cccccaactc tctctgcaag      480

gcctcagggg tcagaacact ggtggagcag atcctttagc ctctggattt tagggccatg      540

gtagaggggg tgttgcccta aattccagcc ctggtctcag cccaacaccc tccaagaaga      600

aattagaggg gccatggcca ggctgtgcta gccgttgctt ctgagcagat tacaagaagg      660

gactaagaca aggactcctt tgtggaggtc ctggcttagg gagtcaagtg acggcggctc      720

agcactcacg tgggcagtgc cagcctctaa gagtgggcag gggcactggc cacagagtcc      780

cagggagtcc caccagccta gtcgccagac cggcaccatg accatcactt acacaagcca      840

agtggctaat gcccgcttag gctccttctc ccgcctgctg ctgtgctggc ggggcagcat      900

ctacaagctg ctatatggcg agttcttaat cttcctgctc tgctactaca tcatccgctt      960

tatttatagg ctggccctca cggaagaaca acagctgatg tttgagaaac tgactctgta     1020

ttgcgacagc tacatccagc tcatccccat ttccttcgtg ctgggcttct acgtgacgct     1080

ggtcgtgacc cgctggtgga accagtacga gaacctgccg tggcccgacc gcctcatgag     1140

cctggtgtcg ggcttcgtcg aaggcaagga cgagcaaggc cggctgctgc ggcgcacgct     1200

catccgctac gccaacctgg gcaacgtgct catcctgcgc agcgtcagca ccgcagtcta     1260

caagcgcttc cccagcgccc agcacctggt gcaagcaggc tttatgactc cggcagaaca     1320

caagcagttg gagaaactga gcctaccaca caacatgttc tgggtgccct gggtgtggtt     1380

tgccaacctg tcaatgaagg cgtggcttgg aggtcgaatc cgggacccta tcctgctcca     1440

gagcctgctg aacgagatga acaccttgcg tactcagtgt ggacacctgt atgcctacga     1500

ctggattagt atcccactgg tgtatacaca ggtggtgact gtggcggtgt acagcttctt     1560

cctgacttgt ctagttgggc ggcagtttct gaacccagcc aaggcctacc ctggccatga     1620

gctggacctc gttgtgcccg tcttcacgtt cctgcagttc ttcttctatg ttggctggct     1680

gaaggtggca gagcagctca tcaacccctt tggagaggat gatgatgatt ttgagaccaa     1740

ctggattgtc gacaggaatt tgcaggtgtc cctgttggct gtggatgaga tgcaccagga     1800

cctgcctcgg atggagccgg acatgtactg gaataagccc gagccacagc ccccctacac     1860

agctgcttcc gcccagttcc gtcgagcctc ctttatgggc tccaccttca acatcagcct     1920

gaacaaagag gagatggagt tccagcccaa tcaggaggac gaggaggatg ctcacgctgg     1980

catcattggc cgcttcctag gcctgcagtc ccatgatcac catcctccca gggcaaactc     2040

aaggaccaaa ctactgtggc ccaagaggga atcccttctc cacgagggcc tgcccaaaaa     2100

ccacaaggca gccaaacaga acgttagggg ccaggaagac aacaaggcct ggaagcttaa     2160

ggctgtggac gccttcaagt ctgccccact gtatcagagg ccaggctact acagtgcccc     2220

acagacgccc ctcagcccca ctcccatgtt cttcccccta gaaccatcag cgccgtcaaa     2280

gcttcacagt gtcacaggca tagacaccaa agacaaaagc ttaaagactg tgagttctgg     2340

ggccaagaaa agttttgaat tgctctcaga gagcgatggg gccttgatgg agcacccaga     2400

agtatctcaa gtgaggagga aaactgtgga gtttaacctg acggatatgc cagagatccc     2460

cgaaaatcac ctcaaagaac ctttggaaca atcaccaacc aacatacaca ctacactcaa     2520

agatcacatg gatccttatt gggccttgga aaacagggat gaagcacatt cctaatctag     2580

cggccgcgaa ttcgatatca agcttatcga taatcaacct ctggattaca aaatttgtga     2640

aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt     2700

aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa     2760

atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt     2820

gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct     2880

cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg     2940

ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc     3000

ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg     3060

gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct     3120

gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc     3180

cctttgggcc gcctccccgg cggccgcgca ccgtcgactc gctgatcagc ctcgactgtg     3240

ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa     3300

ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt     3360

aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa     3420

gacaatagca ggcatgctgg ggatgcggtg ggctctatgg cttctgaggc ggaaagaacc     3480

agctggggct cgactagagc atggctacgt agataagtag catggcgggt taatcattaa     3540

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     3600

tgaggccggg cgaccaaagg tcgcccgacg cccgggcggc ctcagtgagc gagcgagcgc     3660

gcagagcttt ttgcaaaagc ctaggcctcc aaaaaagcct cctcactact tctggaatag     3720

ctcagaggcc gaggcggcct cggcctctgc ataaataaaa aaaattagtc agccatgggg     3780

cggagaatgg gcggaactgg gcggagttag gggcgggatg ggcggagtta ggggcgggac     3840

tatggttgct gactaattga gatgcatgct ttgcatactt ctgcctgctg gggagcctgg     3900

ggactttcca cacctggttg ctgactaatt gagatgcatg ctttgcatac ttctgcctgc     3960

tggggagcct ggggactttc cacaccctaa ctgacacaca ttccacagct gcattaatga     4020

atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc     4080

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     4140

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     4200

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     4260

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     4320

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     4380

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     4440

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     4500

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     4560

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     4620

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     4680

agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     4740

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     4800

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     4860

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa     4920

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata     4980

tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg     5040

atctgtctat ttcgttcatc catagttgcc tgactcctgc aaaccacgtt gtgtctcaaa     5100

atctctgatg ttacattgca caagataaaa atatatcatc atgaacaata aaactgtctg     5160

cttacataaa cagtaataca aggggtgtta tgagccatat tcaacgggaa acgtcttgct     5220

cgaggccgcg attaaattcc aacatggatg ctgatttata tgggtataaa tgggctcgcg     5280

ataatgtcgg gcaatcaggt gcgacaatct atcgattgta tgggaagccc gatgcgccag     5340

agttgtttct gaaacatggc aaaggtagcg ttgccaatga tgttacagat gagatggtca     5400

gactaaactg gctgacggaa tttatgcctc ttccgaccat caagcatttt atccgtactc     5460

ctgatgatgc atggttactc accactgcga tccccgggaa aacagcattc caggtattag     5520

aagaatatcc tgattcaggt gaaaatattg ttgatgcgct ggcagtgttc ctgcgccggt     5580

tgcattcgat tcctgtttgt aattgtcctt ttaacagcga tcgcgtattt cgtctcgctc     5640

aggcgcaatc acgaatgaat aacggtttgg ttgatgcgag tgattttgat gacgagcgta     5700

atggctggcc tgttgaacaa gtctggaaag aaatgcataa gcttttgcca ttctcaccgg     5760

attcagtcgt cactcatggt gatttctcac ttgataacct tatttttgac gaggggaaat     5820

taataggttg tattgatgtt ggacgagtcg gaatcgcaga ccgataccag gatcttgcca     5880

tcctatggaa ctgcctcggt gagttttctc cttcattaca gaaacggctt tttcaaaaat     5940

atggtattga taatcctgat atgaataaat tgcagtttca tttgatgctc gatgagtttt     6000

tctaagggcg gcctgccacc atacccacgc cgaaacaagc gctcatgagc ccgaagtggc     6060

gagcccgatc ttccccatcg gtgatgtcgg cgatataggc gccagcaacc gcacctgtgg     6120

cgccggtgat gccggccacg atgcgtccgg cgtagaggat ctggctagcg atgaccctgc     6180

tgattggttc gctgaccatt tccgggtgcg ggacggcgtt accagaaact cagaaggttc     6240

gtccaaccaa accgactctg acggcagttt acgagagaga tgatagggtc tgcttcaggg     6300

tgaccgatgt aaccatatac ttaggctgga tcttctcccg cgaattttaa ccctcaccaa     6360

ctacgagata tgaggtaagc caaaaaagca cgtagtggcg ctctccgact gttcccaaat     6420

tgtaacttat cgttccgtga aggccagagt tacttcccgg ccctttccat gcgcgcacca     6480

taccctccta gttccccggt tatctttccg aagtgggagt gagcgaacct ccgtttacgt     6540

cttgttacca atgatgtagc tatgcacttt gtacagggtg ccaacgggtt tcacaattca     6600

cagatagtgg ggatcccggc aaagggccta tatttgcggt ccaacttagg cgtaaacctc     6660

gatgctacct actcagaccc acctcgcgcg gggtaaataa ggcactcatc ccagctggtt     6720

cttggcgttc tacgcagcga catgtttatt aacagttgtc tggcagcaca aaacttttac     6780

catggtcgta gaagcccccc agagttagtt catacctaat gccacaaatg tgacaggacg     6840

ccgatgggta ccggacttta ggtcgagcac agttcggtaa cggagagacc ctgcggcgta     6900

cttcattatg tatatggaac gtgcccaagt gacgccaggc aagtctcagc tggttcctgt     6960

gttagctcga gggtagacat acgagctgat tgaacatggg ttgggggcct cgaaccgtcg     7020

aggaccccat agtacctcgg agaccaagta gggcagccta tagtttgaag cagaactatt     7080

tcggggggcg agccctcatc gtctcttctg cggatgactc aacacgctag ggacgtgaag     7140

tcgattcctt cgatggttat aaatcaaaga ctcagagtgc tgtctggagc gtgaatctaa     7200

cggtacgtat ctcgattgct cggtcgcttt tcgcactccg cgaaagttcg taccgctcat     7260

tcactaggtt gcgaagccta tgctgatata tgaatccaaa ctagagcagg gctcttaaga     7320

ttcggagttg taaatactta atactccaat cggcttttac gtgcaccacc gcgggcggct     7380

gacaagggtc tcacatcgag aaacaagaca gttccgggct ggaagtagcg ccggctaagg     7440

aagacgcctg gtacggcagg actatgaaac cagtacaaag gcaacatcct cacttgggtg     7500

aacggaaacg cagtattatg gttacttttt ggatacgtga aacatatccc atggtagtcc     7560

ttagacttgg gagtctatca cccctagggc ccatatctgg aaatagacgc caggttgaat     7620

ccgtatttgg aggtacgatg gaacagtctg ggtgggacgt gcttcattta taccctgcgc     7680

aggctggacc gaggaccgca aggtgcggcg gtgcacaagc aattgacaac taaccaccgt     7740

gtattcatta tggtaccagg aactttaagc cgagtcaatg aagctcgcat tacagtgttt     7800

accgcatctt gccgttactc acaaactgtg atccaccaca agtcaagcca ttgcctctct     7860

gacacgccgt aagaattaat atgtaaactt tgcgcgggtt gactgcgatc cgttcagtct     7920

cgtccgaggg cacaatccta ttcccatttg tatgttcagc taacttctac ccatcccccg     7980

aagttaagta ggtcgtgaga tgccatggag gctctcgttc atcccgtggg acatcaagct     8040

tccccttgat aaagcacccc gctcgggtgt agcagagaag acgccttctg aattgtgcaa     8100

tccctccacc ttatctaagc ttgctaccaa taattagcat ttttgccttg cgacagacct     8160

cctacttaga ttgccacaca ttgagctagt cagtgagcga taagcttgac gcgctttcaa     8220

gggtcgcgag tacgtgaact aaggctccgg acaggactat atacttgggt ttgatctcgc     8280

cccgacaact gcaaacctca acttttttag attatatggt tagccgaagt tgcacgaggt     8340

ggcgtccgcg gactgctccc cgagtgtggc tctttcatct gacaacgtgc aacccctatc     8400

gcggccgatt gtttctgcgg acgatgttgt cctcatagtt tgggcatgtt tcccttgtag     8460

gtgtgaaacc acttagcttc gcgccgtagt cccaatgaaa aacctatgga ctttgttttg     8520

ggtagcacca ggaatctgaa ccgtgtgaat gtggacgtcg cgcgcgtaga cctttatctc     8580

cggttcaagc tagggatgtg gctgcatgct acgttgtcac acctacactg ctcgaagtaa     8640

atatgcgaag cgcgcggcct ggccggaggc gttccgcgcc gccacgtgtt cgttaactgt     8700

tgattggtgg cacataagca atatcgtagt ccgtcaaatt cagctctgtt atcccgggcg     8760

ttatgtgtca aatggcgtag aacgggattg actgtttgac ggtagggtga cctaagccag     8820

atgctacaca attaggcttg tacatattgt cgttagaacg cggctacaat taatacataa     8880

ccttatgtat catacacata cgatttaggt gacactatag aatacacgga attaattc       8938


<210>  14
<211>  9116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  14
tagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctaggtaaa ttctgtcatt ttactagggt gatgaaattc ccaagcaaca ccatcctttt      240

cagataaggg cactgaggct gagagaggag ctgaaaccta cccggggtca ccacacacag      300

gtggcaaggc tgggaccaga aaccaggact gttgactgca gcccggtatt cattctttcc      360

atagcccaca gggctgtcaa agaccccagg gcctagtcag aggctcctcc ttcctggaga      420

gttcctggca cagaagttga agctcagcac agccccctaa cccccaactc tctctgcaag      480

gcctcagggg tcagaacact ggtggagcag atcctttagc ctctggattt tagggccatg      540

gtagaggggg tgttgcccta aattccagcc ctggtctcag cccaacaccc tccaagaaga      600

aattagaggg gccatggcca ggctgtgcta gccgttgctt ctgagcagat tacaagaagg      660

gactaagaca aggactcctt tgtggaggtc ctggcttagg gagtcaagtg acggcggctc      720

agcactcacg tgggcagtgc cagcctctaa gagtgggcag gggcactggc cacagagtcc      780

cagggagtcc caccagccta gtcgccagac cgggtgccgc agggggacgg ctgccttcgg      840

gggggacggg gcagggcggg gttcggcttc tggcgtgtga ccggcggctc tagagcctct      900

gctaaccatg ttcatgcctt cttctttttc ctacagctcc tgggcaacgt gctggttatt      960

gtgctgtctc atcattttgg caaagaattg gcaccatgac catcacttac acaagccaag     1020

tggctaatgc ccgcttaggc tccttctccc gcctgctgct gtgctggcgg ggcagcatct     1080

acaagctgct atatggcgag ttcttaatct tcctgctctg ctactacatc atccgcttta     1140

tttataggct ggccctcacg gaagaacaac agctgatgtt tgagaaactg actctgtatt     1200

gcgacagcta catccagctc atccccattt ccttcgtgct gggcttctac gtgacgctgg     1260

tcgtgacccg ctggtggaac cagtacgaga acctgccgtg gcccgaccgc ctcatgagcc     1320

tggtgtcggg cttcgtcgaa ggcaaggacg agcaaggccg gctgctgcgg cgcacgctca     1380

tccgctacgc caacctgggc aacgtgctca tcctgcgcag cgtcagcacc gcagtctaca     1440

agcgcttccc cagcgcccag cacctggtgc aagcaggctt tatgactccg gcagaacaca     1500

agcagttgga gaaactgagc ctaccacaca acatgttctg ggtgccctgg gtgtggtttg     1560

ccaacctgtc aatgaaggcg tggcttggag gtcgaatccg ggaccctatc ctgctccaga     1620

gcctgctgaa cgagatgaac accttgcgta ctcagtgtgg acacctgtat gcctacgact     1680

ggattagtat cccactggtg tatacacagg tggtgactgt ggcggtgtac agcttcttcc     1740

tgacttgtct agttgggcgg cagtttctga acccagccaa ggcctaccct ggccatgagc     1800

tggacctcgt tgtgcccgtc ttcacgttcc tgcagttctt cttctatgtt ggctggctga     1860

aggtggcaga gcagctcatc aacccctttg gagaggatga tgatgatttt gagaccaact     1920

ggattgtcga caggaatttg caggtgtccc tgttggctgt ggatgagatg caccaggacc     1980

tgcctcggat ggagccggac atgtactgga ataagcccga gccacagccc ccctacacag     2040

ctgcttccgc ccagttccgt cgagcctcct ttatgggctc caccttcaac atcagcctga     2100

acaaagagga gatggagttc cagcccaatc aggaggacga ggaggatgct cacgctggca     2160

tcattggccg cttcctaggc ctgcagtccc atgatcacca tcctcccagg gcaaactcaa     2220

ggaccaaact actgtggccc aagagggaat cccttctcca cgagggcctg cccaaaaacc     2280

acaaggcagc caaacagaac gttaggggcc aggaagacaa caaggcctgg aagcttaagg     2340

ctgtggacgc cttcaagtct gccccactgt atcagaggcc aggctactac agtgccccac     2400

agacgcccct cagccccact cccatgttct tccccctaga accatcagcg ccgtcaaagc     2460

ttcacagtgt cacaggcata gacaccaaag acaaaagctt aaagactgtg agttctgggg     2520

ccaagaaaag ttttgaattg ctctcagaga gcgatggggc cttgatggag cacccagaag     2580

tatctcaagt gaggaggaaa actgtggagt ttaacctgac ggatatgcca gagatccccg     2640

aaaatcacct caaagaacct ttggaacaat caccaaccaa catacacact acactcaaag     2700

atcacatgga tccttattgg gccttggaaa acagggatga agcacattcc taatctagcg     2760

gccgcgaatt cgatatcaag cttatcgata atcaacctct ggattacaaa atttgtgaaa     2820

gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa     2880

tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat     2940

cctggttgct gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt     3000

gcactgtgtt tgctgacgca acccccactg gttggggcat tgccaccacc tgtcagctcc     3060

tttccgggac tttcgctttc cccctcccta ttgccacggc ggaactcatc gccgcctgcc     3120

ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg gtgttgtcgg     3180

ggaaatcatc gtcctttcct tggctgctcg cctgtgttgc cacctggatt ctgcgcggga     3240

cgtccttctg ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc     3300

tgccggctct gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt cggatctccc     3360

tttgggccgc ctccccggcg gccgcgcacc gtcgactcgc tgatcagcct cgactgtgcc     3420

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     3480

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     3540

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     3600

caatagcagg catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag     3660

ctggggctcg actagagcat ggctacgtag ataagtagca tggcgggtta atcattaact     3720

acaaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg     3780

aggccgggcg accaaaggtc gcccgacgcc cgggcggcct cagtgagcga gcgagcgcgc     3840

agagcttttt gcaaaagcct aggcctccaa aaaagcctcc tcactacttc tggaatagct     3900

cagaggccga ggcggcctcg gcctctgcat aaataaaaaa aattagtcag ccatggggcg     3960

gagaatgggc ggaactgggc ggagttaggg gcgggatggg cggagttagg ggcgggacta     4020

tggttgctga ctaattgaga tgcatgcttt gcatacttct gcctgctggg gagcctgggg     4080

actttccaca cctggttgct gactaattga gatgcatgct ttgcatactt ctgcctgctg     4140

gggagcctgg ggactttcca caccctaact gacacacatt ccacagctgc attaatgaat     4200

cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac     4260

tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt     4320

aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca     4380

gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc     4440

ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact     4500

ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct     4560

gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag     4620

ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca     4680

cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa     4740

cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc     4800

gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag     4860

aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg     4920

tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca     4980

gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc     5040

tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag     5100

gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata     5160

tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat     5220

ctgtctattt cgttcatcca tagttgcctg actcctgcaa accacgttgt gtctcaaaat     5280

ctctgatgtt acattgcaca agataaaaat atatcatcat gaacaataaa actgtctgct     5340

tacataaaca gtaatacaag gggtgttatg agccatattc aacgggaaac gtcttgctcg     5400

aggccgcgat taaattccaa catggatgct gatttatatg ggtataaatg ggctcgcgat     5460

aatgtcgggc aatcaggtgc gacaatctat cgattgtatg ggaagcccga tgcgccagag     5520

ttgtttctga aacatggcaa aggtagcgtt gccaatgatg ttacagatga gatggtcaga     5580

ctaaactggc tgacggaatt tatgcctctt ccgaccatca agcattttat ccgtactcct     5640

gatgatgcat ggttactcac cactgcgatc cccgggaaaa cagcattcca ggtattagaa     5700

gaatatcctg attcaggtga aaatattgtt gatgcgctgg cagtgttcct gcgccggttg     5760

cattcgattc ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag     5820

gcgcaatcac gaatgaataa cggtttggtt gatgcgagtg attttgatga cgagcgtaat     5880

ggctggcctg ttgaacaagt ctggaaagaa atgcataagc ttttgccatt ctcaccggat     5940

tcagtcgtca ctcatggtga tttctcactt gataacctta tttttgacga ggggaaatta     6000

ataggttgta ttgatgttgg acgagtcgga atcgcagacc gataccagga tcttgccatc     6060

ctatggaact gcctcggtga gttttctcct tcattacaga aacggctttt tcaaaaatat     6120

ggtattgata atcctgatat gaataaattg cagtttcatt tgatgctcga tgagtttttc     6180

taagggcggc ctgccaccat acccacgccg aaacaagcgc tcatgagccc gaagtggcga     6240

gcccgatctt ccccatcggt gatgtcggcg atataggcgc cagcaaccgc acctgtggcg     6300

ccggtgatgc cggccacgat gcgtccggcg tagaggatct ggctagcgat gaccctgctg     6360

attggttcgc tgaccatttc cgggtgcggg acggcgttac cagaaactca gaaggttcgt     6420

ccaaccaaac cgactctgac ggcagtttac gagagagatg atagggtctg cttcagggtg     6480

accgatgtaa ccatatactt aggctggatc ttctcccgcg aattttaacc ctcaccaact     6540

acgagatatg aggtaagcca aaaaagcacg tagtggcgct ctccgactgt tcccaaattg     6600

taacttatcg ttccgtgaag gccagagtta cttcccggcc ctttccatgc gcgcaccata     6660

ccctcctagt tccccggtta tctttccgaa gtgggagtga gcgaacctcc gtttacgtct     6720

tgttaccaat gatgtagcta tgcactttgt acagggtgcc aacgggtttc acaattcaca     6780

gatagtgggg atcccggcaa agggcctata tttgcggtcc aacttaggcg taaacctcga     6840

tgctacctac tcagacccac ctcgcgcggg gtaaataagg cactcatccc agctggttct     6900

tggcgttcta cgcagcgaca tgtttattaa cagttgtctg gcagcacaaa acttttacca     6960

tggtcgtaga agccccccag agttagttca tacctaatgc cacaaatgtg acaggacgcc     7020

gatgggtacc ggactttagg tcgagcacag ttcggtaacg gagagaccct gcggcgtact     7080

tcattatgta tatggaacgt gcccaagtga cgccaggcaa gtctcagctg gttcctgtgt     7140

tagctcgagg gtagacatac gagctgattg aacatgggtt gggggcctcg aaccgtcgag     7200

gaccccatag tacctcggag accaagtagg gcagcctata gtttgaagca gaactatttc     7260

ggggggcgag ccctcatcgt ctcttctgcg gatgactcaa cacgctaggg acgtgaagtc     7320

gattccttcg atggttataa atcaaagact cagagtgctg tctggagcgt gaatctaacg     7380

gtacgtatct cgattgctcg gtcgcttttc gcactccgcg aaagttcgta ccgctcattc     7440

actaggttgc gaagcctatg ctgatatatg aatccaaact agagcagggc tcttaagatt     7500

cggagttgta aatacttaat actccaatcg gcttttacgt gcaccaccgc gggcggctga     7560

caagggtctc acatcgagaa acaagacagt tccgggctgg aagtagcgcc ggctaaggaa     7620

gacgcctggt acggcaggac tatgaaacca gtacaaaggc aacatcctca cttgggtgaa     7680

cggaaacgca gtattatggt tactttttgg atacgtgaaa catatcccat ggtagtcctt     7740

agacttggga gtctatcacc cctagggccc atatctggaa atagacgcca ggttgaatcc     7800

gtatttggag gtacgatgga acagtctggg tgggacgtgc ttcatttata ccctgcgcag     7860

gctggaccga ggaccgcaag gtgcggcggt gcacaagcaa ttgacaacta accaccgtgt     7920

attcattatg gtaccaggaa ctttaagccg agtcaatgaa gctcgcatta cagtgtttac     7980

cgcatcttgc cgttactcac aaactgtgat ccaccacaag tcaagccatt gcctctctga     8040

cacgccgtaa gaattaatat gtaaactttg cgcgggttga ctgcgatccg ttcagtctcg     8100

tccgagggca caatcctatt cccatttgta tgttcagcta acttctaccc atcccccgaa     8160

gttaagtagg tcgtgagatg ccatggaggc tctcgttcat cccgtgggac atcaagcttc     8220

cccttgataa agcaccccgc tcgggtgtag cagagaagac gccttctgaa ttgtgcaatc     8280

cctccacctt atctaagctt gctaccaata attagcattt ttgccttgcg acagacctcc     8340

tacttagatt gccacacatt gagctagtca gtgagcgata agcttgacgc gctttcaagg     8400

gtcgcgagta cgtgaactaa ggctccggac aggactatat acttgggttt gatctcgccc     8460

cgacaactgc aaacctcaac ttttttagat tatatggtta gccgaagttg cacgaggtgg     8520

cgtccgcgga ctgctccccg agtgtggctc tttcatctga caacgtgcaa cccctatcgc     8580

ggccgattgt ttctgcggac gatgttgtcc tcatagtttg ggcatgtttc ccttgtaggt     8640

gtgaaaccac ttagcttcgc gccgtagtcc caatgaaaaa cctatggact ttgttttggg     8700

tagcaccagg aatctgaacc gtgtgaatgt ggacgtcgcg cgcgtagacc tttatctccg     8760

gttcaagcta gggatgtggc tgcatgctac gttgtcacac ctacactgct cgaagtaaat     8820

atgcgaagcg cgcggcctgg ccggaggcgt tccgcgccgc cacgtgttcg ttaactgttg     8880

attggtggca cataagcaat atcgtagtcc gtcaaattca gctctgttat cccgggcgtt     8940

atgtgtcaaa tggcgtagaa cgggattgac tgtttgacgg tagggtgacc taagccagat     9000

gctacacaat taggcttgta catattgtcg ttagaacgcg gctacaatta atacataacc     9060

ttatgtatca tacacatacg atttaggtga cactatagaa tacacggaat taattc         9116


<210>  15
<211>  7109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  15
tagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctaggtacc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      240

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      300

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      360

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      420

tcatcgctat taccatggtc gaggtgagcc ccacgttctg cttcactctc cccatctccc      480

ccccctcccc acccccaatt ttgtatttat ttatttttta attattttgt gcagcgatgg      540

gggcgggggg gggggggggg cgcgcgccag gcggggcggg gcggggcgag gggcggggcg      600

gggcgaggcg gagaggtgcg gcggcagcca atcagagcgg cgcgctccga aagtttcctt      660

ttatggcgag gcggcggcgg cggcggccct ataaaaagcg aagcgcgcgg cgggcgggag      720

tcgctgcgcg ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      780

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      840

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc      900

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggctg tccgcggggg      960

gacggctgcc ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc     1020

ggctctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca gctcctgggc     1080

aacgtgctgg ttattgtgct gtctcatcat tttggcaaag aattggatcc gcggccgcag     1140

cttggtaccg ccaccatgac catcacttac acaagccaag tggctaatgc ccgcttaggc     1200

tccttctccc gcctgctgct gtgctggcgg ggcagcatct acaagctgct atatggcgag     1260

ttcttaatct tcctgctctg ctactacatc atccgcttta tttataggct ggccctcacg     1320

gaagaacaac agctgatgtt tgagaaactg actctgtatt gcgacagtta catccagctc     1380

atccccattt ccttcgtgct gggcttctac gtgacgctgg tcgtgacccg ctggtggaac     1440

cagtacgaga acctgccgtg gcccgaccgc ctcatgagcc tggtgtcggg cttcgtcgaa     1500

ggcaaggacg agcaaggccg gctgctgcgg cgcacgctca tccgctacgc caacctgggc     1560

aacgtgctca tcctgcgcag cgtcagcacc gcagtctaca agcgcttccc cagcgcccag     1620

cacctggtgc aagcaggctt tatgactccg gcagaacaca agcagttgga gaaactgagc     1680

ctaccacaca acatgttctg ggtgccctgg gtgtggtttg ccaacctgtc aatgaaggcg     1740

tggcttggag gtcgaatccg ggaccctatc ctgctccaga gcctgctgaa cgagatgaac     1800

accttgcgta ctcagtgtgg acacctgtat gcctacgact ggattagtat cccactggtg     1860

tatacacagg tggtgactgt ggcggtgtac agcttcttcc tgacttgtct agttgggcgg     1920

cagtttctga acccagccaa ggcctaccct ggccatgagc tggacctcgt tgtgcccgtc     1980

ttcacgttcc tgcagttctt cttctatgtt ggctggctga aggtggcaga gcagctcatc     2040

aacccctttg gagaggatga tgatgatttt gagaccaact ggattgtcga caggaatttg     2100

caggtgtccc tgttggctgt ggatgagatg caccaggacc tgcctcggat ggagccggac     2160

atgtactgga ataagcccga gccacagccc ccctacacag ctgcttccgc ccagttccgt     2220

cgagcctcct ttatgggctc caccttcaac atcagcctga acaaagagga gatggagttc     2280

cagcccaatc aggaggacga ggaggatgct cacgctggca tcattggccg cttcctaggc     2340

ctgcagtccc atgatcacca tcctcccagg gcaaactcaa ggaccaaact actgtggccc     2400

aagagggaat cccttctcca cgagggcctg cccaaaaacc acaaggcagc caaacagaac     2460

gttaggggcc aggaagacaa caaggcctgg aagcttaagg ctgtggacgc cttcaagtct     2520

gccccactgt atcagaggcc aggctactac agtgccccac agacgcccct cagccccact     2580

cccatgttct tccccctaga accatcagcg ccgtcaaagc ttcacagtgt cacaggcata     2640

gacaccaaag acaaaagctt aaagactgtg agttctgggg ccaagaaaag ttttgaattg     2700

ctctcagaga gcgatggggc cttgatggag cacccagaag tatctcaagt gaggaggaaa     2760

actgtggagt ttaacctgac ggatatgcca gagatccccg aaaatcacct caaagaacct     2820

ttggaacaat caccaaccaa catacacact acactcaaag atcacatgga tccttattgg     2880

gccttggaaa acagggatga agcacattcc taagagctca agcttatcga taatcaacct     2940

ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg     3000

ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc     3060

attttctcct ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt     3120

gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc     3180

attgccacca cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg     3240

gcggaactca tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact     3300

gacaattccg tggtgttgtc ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt     3360

gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg     3420

gaccttcctt cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc     3480

cctcagacga gtcggatctc cctttgggcc gcctccccgc atcgataccg tcgactcgct     3540

gatcagcctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc     3600

cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg     3660

catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca     3720

agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggctt     3780

ctgaggcgga aagaaccagc tggggctcga ctagagcatg gctacgtaga taagtagcat     3840

ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg     3900

cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggcggcctc     3960

agtgagcgag cgagcgcgca gagctttttg caaaagccta ggcctccaaa aaagcctcct     4020

cactacttct ggaatagctc agaggccgag gcggcctcgg cctctgcata aataaaaaaa     4080

attagtcagc catggggcgg agaatgggcg gaactgggcg gagttagggg cgggatgggc     4140

ggagttaggg gcgggactat ggttgctgac taattgagat gcatgctttg catacttctg     4200

cctgctgggg agcctgggga ctttccacac ctggttgctg actaattgag atgcatgctt     4260

tgcatacttc tgcctgctgg ggagcctggg gactttccac accctaactg acacacattc     4320

cacagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     4380

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     4440

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     4500

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     4560

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     4620

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     4680

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     4740

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     4800

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     4860

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4920

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     4980

ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta     5040

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg     5100

gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt     5160

tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg     5220

tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta     5280

aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg     5340

aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg     5400

tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc     5460

gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg     5520

agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg     5580

aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag     5640

gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat     5700

caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc     5760

cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc     5820

ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa     5880

ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac     5940

gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt     6000

cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc     6060

gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa     6120

caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca     6180

tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat     6240

acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa     6300

aagtgccacc tgacgtctaa gaaaccatta ttatcatgac attaacctat aaaaataggc     6360

gtatcacgag gccctttcgt ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca     6420

tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc     6480

gtcagggcgc gtcagcgggt gttggcgggt gtcggggctg gcttaactat gcggcatcag     6540

agcagattgt actgagagtg caccattcga cgctctccct tatgcgactc ctgcattagg     6600

aagcagccca gtagtaggtt gaggccgttg agcaccgccg ccgcaaggaa tggtgcatgc     6660

aaggagatgg cgcccaacag tcccccggcc acggggcctg ccaccatacc cacgccgaaa     6720

caagcgctca tgagcccgaa gtggcgagcc cgatcttccc catcggtgat gtcggcgata     6780

taggcgccag caaccgcacc tgtggcgccg gtgatgccgg ccacgatgcg tccggcgtag     6840

aggatctggc tagcgatgac cctgctgatt ggttcgctga ccatttccgg gtgcgggacg     6900

gcgttaccag aaactcagaa ggttcgtcca accaaaccga ctctgacggc agtttacgag     6960

agagatgata gggtctgctt cagtaagcca gatgctacac aattaggctt gtacatattg     7020

tcgttagaac gcggctacaa ttaatacata accttatgta tcatacacat acgatttagg     7080

tgacactata gaatacacgg aattaattc                                       7109


<210>  16
<211>  7873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  16
tagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctaggtaaa ttctgtcatt ttactagggt gatgaaattc ccaagcaaca ccatcctttt      240

cagataaggg cactgaggct gagagaggag ctgaaaccta cccggggtca ccacacacag      300

gtggcaaggc tgggaccaga aaccaggact gttgactgca gcccggtatt cattctttcc      360

atagcccaca gggctgtcaa agaccccagg gcctagtcag aggctcctcc ttcctggaga      420

gttcctggca cagaagttga agctcagcac agccccctaa cccccaactc tctctgcaag      480

gcctcagggg tcagaacact ggtggagcag atcctttagc ctctggattt tagggccatg      540

gtagaggggg tgttgcccta aattccagcc ctggtctcag cccaacaccc tccaagaaga      600

aattagaggg gccatggcca ggctgtgcta gccgttgctt ctgagcagat tacaagaagg      660

gactaagaca aggactcctt tgtggaggtc ctggcttagg gagtcaagtg acggcggctc      720

agcactcacg tgggcagtgc cagcctctaa gagtgggcag gggcactggc cacagagtcc      780

cagggagtcc caccagccta gtcgccagac cggcaccatg agcaagggcg aggaactgtt      840

cactggcgtg gtcccaattc tcgtggaact ggatggcgat gtgaatgggc acaaattttc      900

tgtcagcgga gagggtgaag gtgatgccac atacggaaag ctcaccctga aattcatctg      960

caccactgga aagctccctg tgccatggcc aacactggtc actaccctga cctatggcgt     1020

gcagtgcttt tccagatacc cagaccatat gaagcagcat gactttttca agagcgccat     1080

gcccgagggc tatgtgcagg agagaaccat ctttttcaaa gatgacggga actacaagac     1140

ccgcgctgaa gtcaagttcg aaggtgacac cctggtgaat agaatcgagc tgaagggcat     1200

tgactttaag gaggatggaa acattctcgg ccacaagctg gaatacaact ataactccca     1260

caatgtgtac atcatggccg acaagcaaaa gaatggcatc aaggtcaact tcaagatcag     1320

acacaacatt gaggatggat ccgtgcagct ggccgaccat tatcaacaga acactccaat     1380

cggcgacggc cctgtgctcc tcccagacaa ccattacctg tccacccagt ctgccctgtc     1440

taaagatccc aacgaaaaga gagaccacat ggtcctgctg gagtttgtga ccgctgctgg     1500

gatcacacat ggcatggacg agctgtacaa gtgaaagctt atcgataatc aacctctgga     1560

ttacaaaatt tgtgaaagat tgactggtat tcttaactat gttgctcctt ttacgctatg     1620

tggatacgct gctttaatgc ctttgtatca tgctattgct tcccgtatgg ctttcatttt     1680

ctcctccttg tataaatcct ggttgctgtc tctttatgag gagttgtggc ccgttgtcag     1740

gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc     1800

caccacctgt cagctccttt ccgggacttt cgctttcccc ctccctattg ccacggcgga     1860

actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa     1920

ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg ctgctcgcct gtgttgccac     1980

ctggattctg cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc cagcggacct     2040

tccttcccgc ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca     2100

gacgagtcgg atctcccttt gggccgcctc cccggcggcc gcgcaccgtc gactcgctga     2160

tcagcctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct     2220

tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca     2280

tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag     2340

ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct     2400

gaggcggaaa gaaccagctg gggctcgact agagcatggc tacgtagata agtagcatgg     2460

cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg     2520

cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gcggcctcag     2580

tgagcgagcg agcgcgcaga gctttttgca aaagcctagg cctccaaaaa agcctcctca     2640

ctacttctgg aatagctcag aggccgaggc ggcctcggcc tctgcataaa taaaaaaaat     2700

tagtcagcca tggggcggag aatgggcgga actgggcgga gttaggggcg ggatgggcgg     2760

agttaggggc gggactatgg ttgctgacta attgagatgc atgctttgca tacttctgcc     2820

tgctggggag cctggggact ttccacacct ggttgctgac taattgagat gcatgctttg     2880

catacttctg cctgctgggg agcctgggga ctttccacac cctaactgac acacattcca     2940

cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct     3000

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca     3060

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac     3120

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt     3180

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg     3240

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc     3300

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc     3360

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc     3420

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac     3480

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt     3540

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct     3600

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc     3660

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt     3720

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg     3780

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc     3840

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa     3900

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     3960

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact cctgcaaacc     4020

acgttgtgtc tcaaaatctc tgatgttaca ttgcacaaga taaaaatata tcatcatgaa     4080

caataaaact gtctgcttac ataaacagta atacaagggg tgttatgagc catattcaac     4140

gggaaacgtc ttgctcgagg ccgcgattaa attccaacat ggatgctgat ttatatgggt     4200

ataaatgggc tcgcgataat gtcgggcaat caggtgcgac aatctatcga ttgtatggga     4260

agcccgatgc gccagagttg tttctgaaac atggcaaagg tagcgttgcc aatgatgtta     4320

cagatgagat ggtcagacta aactggctga cggaatttat gcctcttccg accatcaagc     4380

attttatccg tactcctgat gatgcatggt tactcaccac tgcgatcccc gggaaaacag     4440

cattccaggt attagaagaa tatcctgatt caggtgaaaa tattgttgat gcgctggcag     4500

tgttcctgcg ccggttgcat tcgattcctg tttgtaattg tccttttaac agcgatcgcg     4560

tatttcgtct cgctcaggcg caatcacgaa tgaataacgg tttggttgat gcgagtgatt     4620

ttgatgacga gcgtaatggc tggcctgttg aacaagtctg gaaagaaatg cataagcttt     4680

tgccattctc accggattca gtcgtcactc atggtgattt ctcacttgat aaccttattt     4740

ttgacgaggg gaaattaata ggttgtattg atgttggacg agtcggaatc gcagaccgat     4800

accaggatct tgccatccta tggaactgcc tcggtgagtt ttctccttca ttacagaaac     4860

ggctttttca aaaatatggt attgataatc ctgatatgaa taaattgcag tttcatttga     4920

tgctcgatga gtttttctaa gggcggcctg ccaccatacc cacgccgaaa caagcgctca     4980

tgagcccgaa gtggcgagcc cgatcttccc catcggtgat gtcggcgata taggcgccag     5040

caaccgcacc tgtggcgccg gtgatgccgg ccacgatgcg tccggcgtag aggatctggc     5100

tagcgatgac cctgctgatt ggttcgctga ccatttccgg gtgcgggacg gcgttaccag     5160

aaactcagaa ggttcgtcca accaaaccga ctctgacggc agtttacgag agagatgata     5220

gggtctgctt cagggtgacc gatgtaacca tatacttagg ctggatcttc tcccgcgaat     5280

tttaaccctc accaactacg agatatgagg taagccaaaa aagcacgtag tggcgctctc     5340

cgactgttcc caaattgtaa cttatcgttc cgtgaaggcc agagttactt cccggccctt     5400

tccatgcgcg caccataccc tcctagttcc ccggttatct ttccgaagtg ggagtgagcg     5460

aacctccgtt tacgtcttgt taccaatgat gtagctatgc actttgtaca gggtgccaac     5520

gggtttcaca attcacagat agtggggatc ccggcaaagg gcctatattt gcggtccaac     5580

ttaggcgtaa acctcgatgc tacctactca gacccacctc gcgcggggta aataaggcac     5640

tcatcccagc tggttcttgg cgttctacgc agcgacatgt ttattaacag ttgtctggca     5700

gcacaaaact tttaccatgg tcgtagaagc cccccagagt tagttcatac ctaatgccac     5760

aaatgtgaca ggacgccgat gggtaccgga ctttaggtcg agcacagttc ggtaacggag     5820

agaccctgcg gcgtacttca ttatgtatat ggaacgtgcc caagtgacgc caggcaagtc     5880

tcagctggtt cctgtgttag ctcgagggta gacatacgag ctgattgaac atgggttggg     5940

ggcctcgaac cgtcgaggac cccatagtac ctcggagacc aagtagggca gcctatagtt     6000

tgaagcagaa ctatttcggg gggcgagccc tcatcgtctc ttctgcggat gactcaacac     6060

gctagggacg tgaagtcgat tccttcgatg gttataaatc aaagactcag agtgctgtct     6120

ggagcgtgaa tctaacggta cgtatctcga ttgctcggtc gcttttcgca ctccgcgaaa     6180

gttcgtaccg ctcattcact aggttgcgaa gcctatgctg atatatgaat ccaaactaga     6240

gcagggctct taagattcgg agttgtaaat acttaatact ccaatcggct tttacgtgca     6300

ccaccgcggg cggctgacaa gggtctcaca tcgagaaaca agacagttcc gggctggaag     6360

tagcgccggc taaggaagac gcctggtacg gcaggactat gaaaccagta caaaggcaac     6420

atcctcactt gggtgaacgg aaacgcagta ttatggttac tttttggata cgtgaaacat     6480

atcccatggt agtccttaga cttgggagtc tatcacccct agggcccata tctggaaata     6540

gacgccaggt tgaatccgta tttggaggta cgatggaaca gtctgggtgg gacgtgcttc     6600

atttataccc tgcgcaggct ggaccgagga ccgcaaggtg cggcggtgca caagcaattg     6660

acaactaacc accgtgtatt cattatggta ccaggaactt taagccgagt caatgaagct     6720

cgcattacag tgtttaccgc atcttgccgt tactcacaaa ctgtgatcca ccacaagtca     6780

agccattgcc tctctgacac gccgtaagaa ttaatatgta aactttgcgc gggttgactg     6840

cgatccgttc agtctcgtcc gagggcacaa tcctattccc atttgtatgt tcagctaact     6900

tctacccatc ccccgaagtt aagtaggtcg tgagatgcca tggaggctct cgttcatccc     6960

gtgggacatc aagcttcccc ttgataaagc accccgctcg ggtgtagcag agaagacgcc     7020

ttctgaattg tgcaatccct ccaccttatc taagcttgct accaataatt agcatttttg     7080

ccttgcgaca gacctcctac ttagattgcc acacattgag ctagtcagtg agcgataagc     7140

ttgacgcgct ttcaagggtc gcgagtacgt gaactaaggc tccggacagg actatatact     7200

tgggtttgat ctcgccccga caactgcaaa cctcaacttt tttagattat atggttagcc     7260

gaagttgcac gaggtggcgt ccgcggactg ctccccgagt gtggctcttt catctgacaa     7320

cgtgcaaccc ctatcgcggc cgattgtttc tgcggacgat gttgtcctca tagtttgggc     7380

atgtttccct tgtaggtgtg aaaccactta gcttcgcgcc gtagtcccaa tgaaaaacct     7440

atggactttg ttttgggtag caccaggaat ctgaaccgtg tgaatgtgga cgtcgcgcgc     7500

gtagaccttt atctccggtt caagctaggg atgtggctgc atgctacgtt gtcacaccta     7560

cactgctcga agtaaatatg cgaagcgcgc ggcctggccg gaggcgttcc gcgccgccac     7620

gtgttcgtta actgttgatt ggtggcacat aagcaatatc gtagtccgtc aaattcagct     7680

ctgttatccc gggcgttatg tgtcaaatgg cgtagaacgg gattgactgt ttgacggtag     7740

ggtgacctaa gccagatgct acacaattag gcttgtacat attgtcgtta gaacgcggct     7800

acaattaata cataacctta tgtatcatac acatacgatt taggtgacac tatagaatac     7860

acggaattaa ttc                                                        7873


<210>  17
<211>  8051
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  17
tagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctaggtaaa ttctgtcatt ttactagggt gatgaaattc ccaagcaaca ccatcctttt      240

cagataaggg cactgaggct gagagaggag ctgaaaccta cccggggtca ccacacacag      300

gtggcaaggc tgggaccaga aaccaggact gttgactgca gcccggtatt cattctttcc      360

atagcccaca gggctgtcaa agaccccagg gcctagtcag aggctcctcc ttcctggaga      420

gttcctggca cagaagttga agctcagcac agccccctaa cccccaactc tctctgcaag      480

gcctcagggg tcagaacact ggtggagcag atcctttagc ctctggattt tagggccatg      540

gtagaggggg tgttgcccta aattccagcc ctggtctcag cccaacaccc tccaagaaga      600

aattagaggg gccatggcca ggctgtgcta gccgttgctt ctgagcagat tacaagaagg      660

gactaagaca aggactcctt tgtggaggtc ctggcttagg gagtcaagtg acggcggctc      720

agcactcacg tgggcagtgc cagcctctaa gagtgggcag gggcactggc cacagagtcc      780

cagggagtcc caccagccta gtcgccagac cgggtgccgc agggggacgg ctgccttcgg      840

gggggacggg gcagggcggg gttcggcttc tggcgtgtga ccggcggctc tagagcctct      900

gctaaccatg ttcatgcctt cttctttttc ctacagctcc tgggcaacgt gctggttatt      960

gtgctgtctc atcattttgg caaagaattg gcaccatgag caagggcgag gaactgttca     1020

ctggcgtggt cccaattctc gtggaactgg atggcgatgt gaatgggcac aaattttctg     1080

tcagcggaga gggtgaaggt gatgccacat acggaaagct caccctgaaa ttcatctgca     1140

ccactggaaa gctccctgtg ccatggccaa cactggtcac taccctgacc tatggcgtgc     1200

agtgcttttc cagataccca gaccatatga agcagcatga ctttttcaag agcgccatgc     1260

ccgagggcta tgtgcaggag agaaccatct ttttcaaaga tgacgggaac tacaagaccc     1320

gcgctgaagt caagttcgaa ggtgacaccc tggtgaatag aatcgagctg aagggcattg     1380

actttaagga ggatggaaac attctcggcc acaagctgga atacaactat aactcccaca     1440

atgtgtacat catggccgac aagcaaaaga atggcatcaa ggtcaacttc aagatcagac     1500

acaacattga ggatggatcc gtgcagctgg ccgaccatta tcaacagaac actccaatcg     1560

gcgacggccc tgtgctcctc ccagacaacc attacctgtc cacccagtct gccctgtcta     1620

aagatcccaa cgaaaagaga gaccacatgg tcctgctgga gtttgtgacc gctgctggga     1680

tcacacatgg catggacgag ctgtacaagt gaaagcttat cgataatcaa cctctggatt     1740

acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg     1800

gatacgctgc tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct     1860

cctccttgta taaatcctgg ttgctgtctc tttatgagga gttgtggccc gttgtcaggc     1920

aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc cactggttgg ggcattgcca     1980

ccacctgtca gctcctttcc gggactttcg ctttccccct ccctattgcc acggcggaac     2040

tcatcgccgc ctgccttgcc cgctgctgga caggggctcg gctgttgggc actgacaatt     2100

ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct gctcgcctgt gttgccacct     2160

ggattctgcg cgggacgtcc ttctgctacg tcccttcggc cctcaatcca gcggaccttc     2220

cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga     2280

cgagtcggat ctccctttgg gccgcctccc cggcggccgc gcaccgtcga ctcgctgatc     2340

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     2400

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     2460

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     2520

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga     2580

ggcggaaaga accagctggg gctcgactag agcatggcta cgtagataag tagcatggcg     2640

ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg     2700

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc ggcctcagtg     2760

agcgagcgag cgcgcagagc tttttgcaaa agcctaggcc tccaaaaaag cctcctcact     2820

acttctggaa tagctcagag gccgaggcgg cctcggcctc tgcataaata aaaaaaatta     2880

gtcagccatg gggcggagaa tgggcggaac tgggcggagt taggggcggg atgggcggag     2940

ttaggggcgg gactatggtt gctgactaat tgagatgcat gctttgcata cttctgcctg     3000

ctggggagcc tggggacttt ccacacctgg ttgctgacta attgagatgc atgctttgca     3060

tacttctgcc tgctggggag cctggggact ttccacaccc taactgacac acattccaca     3120

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc     3180

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc     3240

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat     3300

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt     3360

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg     3420

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc     3480

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt     3540

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa     3600

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta     3660

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa     3720

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa     3780

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt     3840

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt     3900

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     3960

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     4020

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc     4080

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc     4140

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc tgcaaaccac     4200

gttgtgtctc aaaatctctg atgttacatt gcacaagata aaaatatatc atcatgaaca     4260

ataaaactgt ctgcttacat aaacagtaat acaaggggtg ttatgagcca tattcaacgg     4320

gaaacgtctt gctcgaggcc gcgattaaat tccaacatgg atgctgattt atatgggtat     4380

aaatgggctc gcgataatgt cgggcaatca ggtgcgacaa tctatcgatt gtatgggaag     4440

cccgatgcgc cagagttgtt tctgaaacat ggcaaaggta gcgttgccaa tgatgttaca     4500

gatgagatgg tcagactaaa ctggctgacg gaatttatgc ctcttccgac catcaagcat     4560

tttatccgta ctcctgatga tgcatggtta ctcaccactg cgatccccgg gaaaacagca     4620

ttccaggtat tagaagaata tcctgattca ggtgaaaata ttgttgatgc gctggcagtg     4680

ttcctgcgcc ggttgcattc gattcctgtt tgtaattgtc cttttaacag cgatcgcgta     4740

tttcgtctcg ctcaggcgca atcacgaatg aataacggtt tggttgatgc gagtgatttt     4800

gatgacgagc gtaatggctg gcctgttgaa caagtctgga aagaaatgca taagcttttg     4860

ccattctcac cggattcagt cgtcactcat ggtgatttct cacttgataa ccttattttt     4920

gacgagggga aattaatagg ttgtattgat gttggacgag tcggaatcgc agaccgatac     4980

caggatcttg ccatcctatg gaactgcctc ggtgagtttt ctccttcatt acagaaacgg     5040

ctttttcaaa aatatggtat tgataatcct gatatgaata aattgcagtt tcatttgatg     5100

ctcgatgagt ttttctaagg gcggcctgcc accataccca cgccgaaaca agcgctcatg     5160

agcccgaagt ggcgagcccg atcttcccca tcggtgatgt cggcgatata ggcgccagca     5220

accgcacctg tggcgccggt gatgccggcc acgatgcgtc cggcgtagag gatctggcta     5280

gcgatgaccc tgctgattgg ttcgctgacc atttccgggt gcgggacggc gttaccagaa     5340

actcagaagg ttcgtccaac caaaccgact ctgacggcag tttacgagag agatgatagg     5400

gtctgcttca gggtgaccga tgtaaccata tacttaggct ggatcttctc ccgcgaattt     5460

taaccctcac caactacgag atatgaggta agccaaaaaa gcacgtagtg gcgctctccg     5520

actgttccca aattgtaact tatcgttccg tgaaggccag agttacttcc cggccctttc     5580

catgcgcgca ccataccctc ctagttcccc ggttatcttt ccgaagtggg agtgagcgaa     5640

cctccgttta cgtcttgtta ccaatgatgt agctatgcac tttgtacagg gtgccaacgg     5700

gtttcacaat tcacagatag tggggatccc ggcaaagggc ctatatttgc ggtccaactt     5760

aggcgtaaac ctcgatgcta cctactcaga cccacctcgc gcggggtaaa taaggcactc     5820

atcccagctg gttcttggcg ttctacgcag cgacatgttt attaacagtt gtctggcagc     5880

acaaaacttt taccatggtc gtagaagccc cccagagtta gttcatacct aatgccacaa     5940

atgtgacagg acgccgatgg gtaccggact ttaggtcgag cacagttcgg taacggagag     6000

accctgcggc gtacttcatt atgtatatgg aacgtgccca agtgacgcca ggcaagtctc     6060

agctggttcc tgtgttagct cgagggtaga catacgagct gattgaacat gggttggggg     6120

cctcgaaccg tcgaggaccc catagtacct cggagaccaa gtagggcagc ctatagtttg     6180

aagcagaact atttcggggg gcgagccctc atcgtctctt ctgcggatga ctcaacacgc     6240

tagggacgtg aagtcgattc cttcgatggt tataaatcaa agactcagag tgctgtctgg     6300

agcgtgaatc taacggtacg tatctcgatt gctcggtcgc ttttcgcact ccgcgaaagt     6360

tcgtaccgct cattcactag gttgcgaagc ctatgctgat atatgaatcc aaactagagc     6420

agggctctta agattcggag ttgtaaatac ttaatactcc aatcggcttt tacgtgcacc     6480

accgcgggcg gctgacaagg gtctcacatc gagaaacaag acagttccgg gctggaagta     6540

gcgccggcta aggaagacgc ctggtacggc aggactatga aaccagtaca aaggcaacat     6600

cctcacttgg gtgaacggaa acgcagtatt atggttactt tttggatacg tgaaacatat     6660

cccatggtag tccttagact tgggagtcta tcacccctag ggcccatatc tggaaataga     6720

cgccaggttg aatccgtatt tggaggtacg atggaacagt ctgggtggga cgtgcttcat     6780

ttataccctg cgcaggctgg accgaggacc gcaaggtgcg gcggtgcaca agcaattgac     6840

aactaaccac cgtgtattca ttatggtacc aggaacttta agccgagtca atgaagctcg     6900

cattacagtg tttaccgcat cttgccgtta ctcacaaact gtgatccacc acaagtcaag     6960

ccattgcctc tctgacacgc cgtaagaatt aatatgtaaa ctttgcgcgg gttgactgcg     7020

atccgttcag tctcgtccga gggcacaatc ctattcccat ttgtatgttc agctaacttc     7080

tacccatccc ccgaagttaa gtaggtcgtg agatgccatg gaggctctcg ttcatcccgt     7140

gggacatcaa gcttcccctt gataaagcac cccgctcggg tgtagcagag aagacgcctt     7200

ctgaattgtg caatccctcc accttatcta agcttgctac caataattag catttttgcc     7260

ttgcgacaga cctcctactt agattgccac acattgagct agtcagtgag cgataagctt     7320

gacgcgcttt caagggtcgc gagtacgtga actaaggctc cggacaggac tatatacttg     7380

ggtttgatct cgccccgaca actgcaaacc tcaacttttt tagattatat ggttagccga     7440

agttgcacga ggtggcgtcc gcggactgct ccccgagtgt ggctctttca tctgacaacg     7500

tgcaacccct atcgcggccg attgtttctg cggacgatgt tgtcctcata gtttgggcat     7560

gtttcccttg taggtgtgaa accacttagc ttcgcgccgt agtcccaatg aaaaacctat     7620

ggactttgtt ttgggtagca ccaggaatct gaaccgtgtg aatgtggacg tcgcgcgcgt     7680

agacctttat ctccggttca agctagggat gtggctgcat gctacgttgt cacacctaca     7740

ctgctcgaag taaatatgcg aagcgcgcgg cctggccgga ggcgttccgc gccgccacgt     7800

gttcgttaac tgttgattgg tggcacataa gcaatatcgt agtccgtcaa attcagctct     7860

gttatcccgg gcgttatgtg tcaaatggcg tagaacggga ttgactgttt gacggtaggg     7920

tgacctaagc cagatgctac acaattaggc ttgtacatat tgtcgttaga acgcggctac     7980

aattaataca taaccttatg tatcatacac atacgattta ggtgacacta tagaatacac     8040

ggaattaatt c                                                          8051


