                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
       Gromada, Jesper
       Stevis, Panayiotis
       Altarejos, Judith
       Murphy, Andrew J.
 
<120>  METHODS OF TREATMENT USING A LEPTIN RECEPTOR AGONIST ANTIBODY

<130>  9774.436WO1/10436WO01

<140>  TBD
<141>  2019-04-05

<160>  120   

<170>  PatentIn version 3.5

<210>  1
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc       60

tcctgtgtag cgtctggatt caccttcagt tccgatgcca tgtactgggt ccgccaggct      120

ccaggcaagg ggctggaatg ggtggcagtt atttattatg atggaaatta tcaatactat      180

gaagactccg ttaagggtcg attcaccatc tccagagaca attcccagaa cacgctggat      240

ctgcaaatga acagcctgag agtcgacgac acggctgtat atttctgtgc gcgtctcaac      300

tgggattact ggtatctcga tctctggggc cgtggcaccc tggtcactgt ctcctca         357


<210>  2
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Asp 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Tyr Tyr Asp Gly Asn Tyr Gln Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Leu Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Asn Trp Asp Tyr Trp Tyr Leu Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3
ggattcacct tcagttccga tgcc                                              24


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Gly Phe Thr Phe Ser Ser Asp Ala 
1               5               


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5
atttattatg atggaaatta tcaa                                              24


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Ile Tyr Tyr Asp Gly Asn Tyr Gln 
1               5               


<210>  7
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7
gcgcgtctca actgggatta ctggtatctc gatctc                                 36


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8

Ala Arg Leu Asn Trp Asp Tyr Trp Tyr Leu Asp Leu 
1               5                   10          


<210>  9
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  10
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  11
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11
cagagcatta gcagctat                                                     18


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  13
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13
gctgcatcc                                                                9


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14

Ala Ala Ser 
1           


<210>  15
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15
caacagagtt acagtacccc tccgatcacc                                        30


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16

Gln Gln Ser Tyr Ser Thr Pro Pro Ile Thr 
1               5                   10  


<210>  17
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17
caggtgcagc tggtggagtc cgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtacag cgtctggatt caccttcagt agttatgcca tgtactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgtcagtt atatactatg atggaagtta taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatgg acagcctgag agccgaggac acggctgtct attactgtgc gagttataac      300

tggaactact ggtacttcga tttctggggc cgtggcaccc tggtcactgt ctcctca         357


<210>  18
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Tyr Asn Trp Asn Tyr Trp Tyr Phe Asp Phe Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19
ggattcacct tcagtagtta tgcc                                              24


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21
atatactatg atggaagtta taaa                                              24


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22

Ile Tyr Tyr Asp Gly Ser Tyr Lys 
1               5               


<210>  23
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23
gcgagttata actggaacta ctggtacttc gatttc                                 36


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24

Ala Ser Tyr Asn Trp Asn Tyr Trp Tyr Phe Asp Phe 
1               5                   10          


<210>  25
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25
caggtgcagc tggtggagtc tgggggaagc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt acatatgcca tgtactgggt ccgccagact      120

ccaggcaagg ggctggagtg ggtggctgtt ttatactctg atggaagtaa taaatactat      180

atagactccg tgaagggccg attcaccatc tccagagaca cttccacgaa cactctgtat      240

ctgcaaatga gcagcctgcg agccgacgac tcggctctat attactgtgc gcgtctcaac      300

tgggattact ggtacttcga tctctggggc cgtggcaccc tggtcactgt ctcctca         357


<210>  26
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Ser Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Leu Tyr Ser Asp Gly Ser Asn Lys Tyr Tyr Ile Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Thr Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Asp Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Asn Trp Asp Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27
ggattcacct tcagtacata tgcc                                              24


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28

Gly Phe Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  29
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29
ttatactctg atggaagtaa taaa                                              24


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30

Leu Tyr Ser Asp Gly Ser Asn Lys 
1               5               


<210>  31
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31
gcgcgtctca actgggatta ctggtacttc gatctc                                 36


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32

Ala Arg Leu Asn Trp Asp Tyr Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  33
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgaag cgtctggatt cagcagcagt gacaatgcca tgtactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgtcagtt atatatcatg atggaagtta taaatactat      180

gaagactccg tgaagggccg attcaccatc gccagagaca attccaagaa cacgctttat      240

ttgcaaatga acagcctgag agccgaggac acggctgtat attactgtgc gaggtataac      300

tggaaccact ggtacttcga tgtctggggc cgtggcaccc tggtcactgt ctcctca         357


<210>  34
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Ser Ser Ser Asp Asn 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr His Asp Gly Ser Tyr Lys Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asn Trp Asn His Trp Tyr Phe Asp Val Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35
ggattcagca gcagtgacaa tgcc                                              24


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36

Gly Phe Ser Ser Ser Asp Asn Ala 
1               5               


<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37
atatatcatg atggaagtta taaa                                              24


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38

Ile Tyr His Asp Gly Ser Tyr Lys 
1               5               


<210>  39
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39
gcgaggtata actggaacca ctggtacttc gatgtc                                 36


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40

Ala Arg Tyr Asn Trp Asn His Trp Tyr Phe Asp Val 
1               5                   10          


<210>  41
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt acctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgtcagtt atatcatatg acgaaagtaa taagtactat      180

gcagactccg tgaagggccg attcaccatt tctagagaca attccaagaa cgcgctgtat      240

ttacaaatga acagcctgag aaatgaggac acggctgtgt attactgtgc gagagatcgg      300

ccttttggat tggttaccgg atggttcgac ccctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  42
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Tyr Asp Glu Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asn Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Pro Phe Gly Leu Val Thr Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43
ggattcacct tcagtaccta tggc                                              24


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44

Gly Phe Thr Phe Ser Thr Tyr Gly 
1               5               


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45
atatcatatg acgaaagtaa taag                                              24


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46

Ile Ser Tyr Asp Glu Ser Asn Lys 
1               5               


<210>  47
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47
gcgagagatc ggccttttgg attggttacc ggatggttcg acccc                       45


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48

Ala Arg Asp Arg Pro Phe Gly Leu Val Thr Gly Trp Phe Asp Pro 
1               5                   10                  15  


<210>  49
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt cagtttcaat acctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacaatt atatggtatg atggaagtat taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attattgtgc gagaggtgga      300

tatagtggct acctctactt tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  50
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Ile Ile Trp Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Ser Gly Tyr Leu Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  51
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51
ggattcagtt tcaataccta tggc                                              24


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52

Gly Phe Ser Phe Asn Thr Tyr Gly 
1               5               


<210>  53
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  53
atatggtatg atggaagtat taaa                                              24


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  54

Ile Trp Tyr Asp Gly Ser Ile Lys 
1               5               


<210>  55
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  55
gcgagaggtg gatatagtgg ctacctctac tttgactac                              39


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  56

Ala Arg Gly Gly Tyr Ser Gly Tyr Leu Tyr Phe Asp Tyr 
1               5                   10              


<210>  57
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  57
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agcggtggtg actactggag ctggatccgc      120

cagctcccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcgcctac      180

tataatccgt ccctcaagag tcgaggtacc atatcaatag acacgtctaa gaaccagttc      240

tccctgaagc tgacctctgt gactgccgcg gacacggccg tatatttctg tgtgaaatta      300

cgatttttgg agtggttctt ggggggctgg ttcggcccct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210>  58
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  58

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Asp Tyr Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Ala Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Gly Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Val Lys Leu Arg Phe Leu Glu Trp Phe Leu Gly Gly Trp Phe Gly 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  59
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  59
ggtggctcca tcagcagcgg tggtgactac                                        30


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  60

Gly Gly Ser Ile Ser Ser Gly Gly Asp Tyr 
1               5                   10  


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  61
atctattaca gtgggagcgc c                                                 21


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  62

Ile Tyr Tyr Ser Gly Ser Ala 
1               5           


<210>  63
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  63
gtgaaattac gatttttgga gtggttcttg gggggctggt tcggcccc                    48


<210>  64
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  64

Val Lys Leu Arg Phe Leu Glu Trp Phe Leu Gly Gly Trp Phe Gly Pro 
1               5                   10                  15      


<210>  65
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  65
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc aactatggca tgacctgggt ccgccaggct      120

ccagggaagg gcctggaatg ggtctcagct attactggtg gtggtggtag cacatactac      180

tcaaactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacggtgtat      240

ctgcgaatga acagtgtgag agccgaggac acggccgtat attactgtgc gaaatataag      300

tggaacttcg tggacgactg gggccaggga accacggtca ccgtctcctc a               351


<210>  66
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Gly Gly Gly Gly Ser Thr Tyr Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Arg Met Asn Ser Val Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Lys Trp Asn Phe Val Asp Asp Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  67
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  67
ggattcacct ttagcaacta tggc                                              24


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  68

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  69
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  69
attactggtg gtggtggtag caca                                              24


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  70

Ile Thr Gly Gly Gly Gly Ser Thr 
1               5               


<210>  71
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  71
gcgaaatata agtggaactt cgtggacgac                                        30


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  72

Ala Lys Tyr Lys Trp Asn Phe Val Asp Asp 
1               5                   10  


<210>  73
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  73
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgttg cctctggatt caccttcaat aaatacgaca tgcactgggt ccgccaaact      120

actggaaaag gtctagagtg ggtctcaggt attgatactg atggtgacac atactatcca      180

ggctccgtga agggccgatt caccatctcc agagaaaatg ccgagaactc cctgtatctt      240

caaatgaacg gcctgagagt cggggacacg gctgtgtatt actgtgcaag atggccttgg      300

agtggtttct atggtgcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      360


<210>  74
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Thr Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asp Thr Asp Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Glu Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Gly Leu Arg Val Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Pro Trp Ser Gly Phe Tyr Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  75
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  75
ggattcacct tcaataaata cgac                                              24


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  76

Gly Phe Thr Phe Asn Lys Tyr Asp 
1               5               


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  77
attgatactg atggtgacac a                                                 21


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  78

Ile Asp Thr Asp Gly Asp Thr 
1               5           


<210>  79
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  79
gcaagatggc cttggagtgg tttctatggt gcttttgata tc                          42


<210>  80
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  80

Ala Arg Trp Pro Trp Ser Gly Phe Tyr Gly Ala Phe Asp Ile 
1               5                   10                  


<210>  81
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  81
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtaatt actactggaa ctggatccgc      120

caacagccag gagagggcct ggagtggatt gcttacatct atcacaatgg ggtcaccaac      180

ttcaatccgt ccctcaagag tcgacttact atatcagtag acacgtctaa gactcagttc      240

tccctgaagt tgaggtctgt gactgccgcg gacacggccg tttattactg tgcgagatca      300

ggcagctggt tcgagaactg gtacttcgat ctctggggcc gtggcaccct ggtcactgtc      360

tcctca                                                                 366


<210>  82
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  82

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asn Tyr Tyr Trp Asn Trp Ile Arg Gln Gln Pro Gly Glu Gly Leu Glu 
        35                  40                  45              


Trp Ile Ala Tyr Ile Tyr His Asn Gly Val Thr Asn Phe Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Gly Ser Trp Phe Glu Asn Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  83
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  83
ggtggctcca tcagcagtgg taattactac                                        30


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  84

Gly Gly Ser Ile Ser Ser Gly Asn Tyr Tyr 
1               5                   10  


<210>  85
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  85
atctatcaca atggggtcac c                                                 21


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  86

Ile Tyr His Asn Gly Val Thr 
1               5           


<210>  87
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  87
gcgagatcag gcagctggtt cgagaactgg tacttcgatc tc                          42


<210>  88
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  88

Ala Arg Ser Gly Ser Trp Phe Glu Asn Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  89
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  89
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccttg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210>  90
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  90

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  91
cagagtgtta gcagcagcta c                                                 21


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  92

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  93
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  93
ggtgcatcc                                                                9


<210>  94
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  94

Gly Ala Ser 
1           


<210>  95
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  95
cagcagtatg gtagctcacc ttggacg                                           27


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  96

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  97
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  97
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt aattcctact ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gattggatat gtctattccc gtgggaacac caagtacaac      180

ccctccctca cgagtcgagt caccatgtca tttgacacgt ccaagaacca gttctccctg      240

aaactgaggt ctgtgaccgc cgcagacacg gccgtgtatt actgtgcgag aagcagcagc      300

tggtacgagg actggtactt cgatctctgg ggccgtggca ccctggtcac tgtctcctca      360


<210>  98
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  98

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Ser 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Tyr Ser Arg Gly Asn Thr Lys Tyr Asn Pro Ser Leu Thr 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Phe Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Ser Ser Trp Tyr Glu Asp Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  99
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  99
ggtggctcca tcagtaattc ctac                                              24


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  100

Gly Gly Ser Ile Ser Asn Ser Tyr 
1               5               


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  101
gtctattccc gtgggaacac c                                                 21


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  102

Val Tyr Ser Arg Gly Asn Thr 
1               5           


<210>  103
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  103
gcgagaagca gcagctggta cgaggactgg tacttcgatc tc                          42


<210>  104
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  104

Ala Arg Ser Ser Ser Trp Tyr Glu Asp Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  105
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  105
caggtgcagc tacagcagtg gggcgcaggg ctgtttaagc cttcggagac cctgtccctc       60

acctgcgatg tctatggtgg gtccttcaga ggttattatt ggagttggat ccgccagccc      120

ccagggaagg ggctggagtg gattggggaa atcagttata gtggtttcac caattacaac      180

ccgtccctca agagtcgagt catcatatca atagatacgt ccaagaacca gttctccctg      240

aagatgagct ctgtgaccgc cgcggacacg gctgtttatt actgtgcgag agttacctat      300

ggttatggga cctttgatta ttggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  106
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  106

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Phe Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Asp Val Tyr Gly Gly Ser Phe Arg Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ser Tyr Ser Gly Phe Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Ile Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Thr Tyr Gly Tyr Gly Thr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  107
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  107
ggtgggtcct tcagaggtta ttat                                              24


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  108

Gly Gly Ser Phe Arg Gly Tyr Tyr 
1               5               


<210>  109
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  109
atcagttata gtggtttcac c                                                 21


<210>  110
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  110

Ile Ser Tyr Ser Gly Phe Thr 
1               5           


<210>  111
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  111
gcgagagtta cctatggtta tgggaccttt gattat                                 36


<210>  112
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  112

Ala Arg Val Thr Tyr Gly Tyr Gly Thr Phe Asp Tyr 
1               5                   10          


<210>  113
<211>  1165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLEPR Accession No P48357

<400>  113

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                  15      


Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                  25                  30          


Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                  40                  45              


Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                  55                  60                  


Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                  70                  75                  80  


Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                  90                  95      


Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                 105                 110         


Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                 120                 125             


Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                 135                 140                 


Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                 170                 175     


Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                 185                 190         


Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                 200                 205             


Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                 215                 220                 


Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                 230                 235                 240 


Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                 250                 255     


Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                 265                 270         


Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                 280                 285             


Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                 295                 300                 


Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                 310                 315                 320 


Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                 330                 335     


Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                 345                 350         


Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                 360                 365             


Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                 375                 380                 


Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                 390                 395                 400 


Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                 410                 415     


Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                 425                 430         


Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                 440                 445             


Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                 455                 460                 


Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                 470                 475                 480 


Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                 490                 495     


Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                 505                 510         


Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                 520                 525             


Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                 535                 540                 


Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                 550                 555                 560 


Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                 570                 575     


Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                 585                 590         


Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                 600                 605             


Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                 615                 620                 


Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                 630                 635                 640 


Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                 650                 655     


Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                 665                 670         


Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                 680                 685             


Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                 695                 700                 


Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                 710                 715                 720 


Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                 730                 735     


Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                 745                 750         


Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                 760                 765             


Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                 775                 780                 


Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                 790                 795                 800 


Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                 810                 815     


Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                 825                 830         


Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                 840                 845             


Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                 855                 860                 


Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                 870                 875                 880 


Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Pro Glu Thr Phe Glu 
                885                 890                 895     


His Leu Phe Ile Lys His Thr Ala Ser Val Thr Cys Gly Pro Leu Leu 
            900                 905                 910         


Leu Glu Pro Glu Thr Ile Ser Glu Asp Ile Ser Val Asp Thr Ser Trp 
        915                 920                 925             


Lys Asn Lys Asp Glu Met Met Pro Thr Thr Val Val Ser Leu Leu Ser 
    930                 935                 940                 


Thr Thr Asp Leu Glu Lys Gly Ser Val Cys Ile Ser Asp Gln Phe Asn 
945                 950                 955                 960 


Ser Val Asn Phe Ser Glu Ala Glu Gly Thr Glu Val Thr Tyr Glu Asp 
                965                 970                 975     


Glu Ser Gln Arg Gln Pro Phe Val Lys Tyr Ala Thr Leu Ile Ser Asn 
            980                 985                 990         


Ser Lys Pro Ser Glu Thr Gly Glu  Glu Gln Gly Leu Ile  Asn Ser Ser 
        995                 1000                 1005             


Val Thr  Lys Cys Phe Ser Ser  Lys Asn Ser Pro Leu  Lys Asp Ser 
    1010                 1015                 1020             


Phe Ser  Asn Ser Ser Trp Glu  Ile Glu Ala Gln Ala  Phe Phe Ile 
    1025                 1030                 1035             


Leu Ser  Asp Gln His Pro Asn  Ile Ile Ser Pro His  Leu Thr Phe 
    1040                 1045                 1050             


Ser Glu  Gly Leu Asp Glu Leu  Leu Lys Leu Glu Gly  Asn Phe Pro 
    1055                 1060                 1065             


Glu Glu  Asn Asn Asp Lys Lys  Ser Ile Tyr Tyr Leu  Gly Val Thr 
    1070                 1075                 1080             


Ser Ile  Lys Lys Arg Glu Ser  Gly Val Leu Leu Thr  Asp Lys Ser 
    1085                 1090                 1095             


Arg Val  Ser Cys Pro Phe Pro  Ala Pro Cys Leu Phe  Thr Asp Ile 
    1100                 1105                 1110             


Arg Val  Leu Gln Asp Ser Cys  Ser His Phe Val Glu  Asn Asn Ile 
    1115                 1120                 1125             


Asn Leu  Gly Thr Ser Ser Lys  Lys Thr Phe Ala Ser  Tyr Met Pro 
    1130                 1135                 1140             


Gln Phe  Gln Thr Cys Ser Thr  Gln Thr His Lys Ile  Met Glu Asn 
    1145                 1150                 1155             


Lys Met  Cys Asp Leu Thr Val  
    1160                 1165 


<210>  114
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLEPR.mmh aa 1-818: F22-D839 of P48357 aa 819-846: 
       myc-myc-hexahistidine tag

<400>  114

Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg Phe Lys Leu Ser Cys 
1               5                   10                  15      


Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu Leu Pro Ala Gly Leu 
            20                  25                  30          


Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr Glu Thr Ala Val Glu 
        35                  40                  45              


Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser Asn Leu Ser Lys Thr 
    50                  55                  60                  


Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp Arg Asn Cys Ser Leu 
65                  70                  75                  80  


Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val Ser Thr Val Asn Ser 
                85                  90                  95      


Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn Ile Gln Cys Trp Leu 
            100                 105                 110         


Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val Glu Ser Leu Phe Lys 
        115                 120                 125             


Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His Leu Leu Tyr Val Leu 
    130                 135                 140                 


Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro Gln Lys Gly Ser Phe 
145                 150                 155                 160 


Gln Met Val His Cys Asn Cys Ser Val His Glu Cys Cys Glu Cys Leu 
                165                 170                 175     


Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr Leu Leu Met Cys Leu 
            180                 185                 190         


Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser Pro Leu Met Ser Val 
        195                 200                 205             


Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro Leu Gly Leu His Met 
    210                 215                 220                 


Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser Trp Ser Ser Pro Pro 
225                 230                 235                 240 


Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys Tyr Ser Glu Asn Ser 
                245                 250                 255     


Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val Ser Ala Thr Ser Leu 
            260                 265                 270         


Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr Glu Val Gln Val Arg 
        275                 280                 285             


Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser Asp Trp Ser Thr Pro 
    290                 295                 300                 


Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe Pro Pro Lys Ile Leu 
305                 310                 315                 320 


Thr Ser Val Gly Ser Asn Val Ser Phe His Cys Ile Tyr Lys Lys Glu 
                325                 330                 335     


Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp Trp Met Asn Leu Ala 
            340                 345                 350         


Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val Ser Asp His Val Ser 
        355                 360                 365             


Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys Pro Arg Gly Lys Phe 
    370                 375                 380                 


Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His Glu Cys His His Arg 
385                 390                 395                 400 


Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile Asn Ile Ser Cys Glu 
                405                 410                 415     


Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg Trp Ser Thr Ser Thr 
            420                 425                 430         


Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu Arg Tyr His Arg Ser 
        435                 440                 445             


Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His Pro Ile Ser Glu Pro 
    450                 455                 460                 


Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr Glu Cys Ile Phe Gln 
465                 470                 475                 480 


Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp Ile Arg Ile Asn His 
                485                 490                 495     


Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys Val Leu Pro Asp Ser 
            500                 505                 510         


Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys Ala Glu Ile Thr Ile 
        515                 520                 525             


Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys Pro Val Phe Pro Glu 
    530                 535                 540                 


Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu Ser Gly Lys Glu Val 
545                 550                 555                 560 


Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys Ser Lys Ser Val Ser 
                565                 570                 575     


Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala Val Gln Val Arg Cys 
            580                 585                 590         


Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn Trp Ser Asn Pro Ala 
        595                 600                 605             


Tyr Thr Val Val Met Asp Ile Lys Val Pro Met Arg Gly Pro Glu Phe 
    610                 615                 620                 


Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys Glu Lys Asn Val Thr 
625                 630                 635                 640 


Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser Leu Cys Ser Val Gln 
                645                 650                 655     


Arg Tyr Val Ile Asn His His Thr Ser Cys Asn Gly Thr Trp Ser Glu 
            660                 665                 670         


Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu Trp Thr Glu Gln Ala 
        675                 680                 685             


His Thr Val Thr Val Leu Ala Ile Asn Ser Ile Gly Ala Ser Val Ala 
    690                 695                 700                 


Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser Lys Val Asn Ile Val 
705                 710                 715                 720 


Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser Cys Val Ile Val Ser 
                725                 730                 735     


Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met Tyr Phe Ile Ile Glu 
            740                 745                 750         


Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys Trp Leu Arg Ile Ser 
        755                 760                 765             


Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His Phe Ile Pro Ile Glu 
    770                 775                 780                 


Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met Glu Gly Val Gly Lys 
785                 790                 795                 800 


Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp Ile Glu Lys His Gln 
                805                 810                 815     


Ser Asp Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln 
            820                 825                 830         


Lys Leu Ile Ser Glu Glu Asp Leu His His His His His His 
        835                 840                 845     


<210>  115
<211>  1051
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLEPR.mFc aa 1-818: F22-D839 of P48357 aa 819-1051: mouse IgG2a 
       (E98-K330 of P01863)

<400>  115

Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg Phe Lys Leu Ser Cys 
1               5                   10                  15      


Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu Leu Pro Ala Gly Leu 
            20                  25                  30          


Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr Glu Thr Ala Val Glu 
        35                  40                  45              


Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser Asn Leu Ser Lys Thr 
    50                  55                  60                  


Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp Arg Asn Cys Ser Leu 
65                  70                  75                  80  


Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val Ser Thr Val Asn Ser 
                85                  90                  95      


Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn Ile Gln Cys Trp Leu 
            100                 105                 110         


Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val Glu Ser Leu Phe Lys 
        115                 120                 125             


Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His Leu Leu Tyr Val Leu 
    130                 135                 140                 


Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro Gln Lys Gly Ser Phe 
145                 150                 155                 160 


Gln Met Val His Cys Asn Cys Ser Val His Glu Cys Cys Glu Cys Leu 
                165                 170                 175     


Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr Leu Leu Met Cys Leu 
            180                 185                 190         


Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser Pro Leu Met Ser Val 
        195                 200                 205             


Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro Leu Gly Leu His Met 
    210                 215                 220                 


Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser Trp Ser Ser Pro Pro 
225                 230                 235                 240 


Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys Tyr Ser Glu Asn Ser 
                245                 250                 255     


Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val Ser Ala Thr Ser Leu 
            260                 265                 270         


Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr Glu Val Gln Val Arg 
        275                 280                 285             


Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser Asp Trp Ser Thr Pro 
    290                 295                 300                 


Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe Pro Pro Lys Ile Leu 
305                 310                 315                 320 


Thr Ser Val Gly Ser Asn Val Ser Phe His Cys Ile Tyr Lys Lys Glu 
                325                 330                 335     


Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp Trp Met Asn Leu Ala 
            340                 345                 350         


Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val Ser Asp His Val Ser 
        355                 360                 365             


Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys Pro Arg Gly Lys Phe 
    370                 375                 380                 


Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His Glu Cys His His Arg 
385                 390                 395                 400 


Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile Asn Ile Ser Cys Glu 
                405                 410                 415     


Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg Trp Ser Thr Ser Thr 
            420                 425                 430         


Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu Arg Tyr His Arg Ser 
        435                 440                 445             


Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His Pro Ile Ser Glu Pro 
    450                 455                 460                 


Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr Glu Cys Ile Phe Gln 
465                 470                 475                 480 


Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp Ile Arg Ile Asn His 
                485                 490                 495     


Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys Val Leu Pro Asp Ser 
            500                 505                 510         


Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys Ala Glu Ile Thr Ile 
        515                 520                 525             


Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys Pro Val Phe Pro Glu 
    530                 535                 540                 


Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu Ser Gly Lys Glu Val 
545                 550                 555                 560 


Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys Ser Lys Ser Val Ser 
                565                 570                 575     


Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala Val Gln Val Arg Cys 
            580                 585                 590         


Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn Trp Ser Asn Pro Ala 
        595                 600                 605             


Tyr Thr Val Val Met Asp Ile Lys Val Pro Met Arg Gly Pro Glu Phe 
    610                 615                 620                 


Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys Glu Lys Asn Val Thr 
625                 630                 635                 640 


Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser Leu Cys Ser Val Gln 
                645                 650                 655     


Arg Tyr Val Ile Asn His His Thr Ser Cys Asn Gly Thr Trp Ser Glu 
            660                 665                 670         


Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu Trp Thr Glu Gln Ala 
        675                 680                 685             


His Thr Val Thr Val Leu Ala Ile Asn Ser Ile Gly Ala Ser Val Ala 
    690                 695                 700                 


Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser Lys Val Asn Ile Val 
705                 710                 715                 720 


Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser Cys Val Ile Val Ser 
                725                 730                 735     


Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met Tyr Phe Ile Ile Glu 
            740                 745                 750         


Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys Trp Leu Arg Ile Ser 
        755                 760                 765             


Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His Phe Ile Pro Ile Glu 
    770                 775                 780                 


Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met Glu Gly Val Gly Lys 
785                 790                 795                 800 


Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp Ile Glu Lys His Gln 
                805                 810                 815     


Ser Asp Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 
            820                 825                 830         


Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
        835                 840                 845             


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr 
    850                 855                 860                 


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
865                 870                 875                 880 


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
                885                 890                 895     


Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
            900                 905                 910         


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
        915                 920                 925             


Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
    930                 935                 940                 


Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
945                 950                 955                 960 


Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 
                965                 970                 975     


Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 
            980                 985                 990         


Leu Asn Tyr Lys Asn Thr Glu Pro  Val Leu Asp Ser Asp  Gly Ser Tyr 
        995                 1000                 1005             


Phe Met  Tyr Ser Lys Leu Arg  Val Glu Lys Lys Asn  Trp Val Glu 
    1010                 1015                 1020             


Arg Asn  Ser Tyr Ser Cys Ser  Val Val His Glu Gly  Leu His Asn 
    1025                 1030                 1035             


His His  Thr Thr Lys Ser Phe  Ser Arg Thr Pro Gly  Lys 
    1040                 1045                 1050     


<210>  116
<211>  1045
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLEPR.hFc aa 1-818: F22-D839 of P48357 aa 819-1045: human IgG1 
       tag (D104-K330 of P01857)

<400>  116

Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg Phe Lys Leu Ser Cys 
1               5                   10                  15      


Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu Leu Pro Ala Gly Leu 
            20                  25                  30          


Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr Glu Thr Ala Val Glu 
        35                  40                  45              


Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser Asn Leu Ser Lys Thr 
    50                  55                  60                  


Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp Arg Asn Cys Ser Leu 
65                  70                  75                  80  


Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val Ser Thr Val Asn Ser 
                85                  90                  95      


Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn Ile Gln Cys Trp Leu 
            100                 105                 110         


Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val Glu Ser Leu Phe Lys 
        115                 120                 125             


Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His Leu Leu Tyr Val Leu 
    130                 135                 140                 


Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro Gln Lys Gly Ser Phe 
145                 150                 155                 160 


Gln Met Val His Cys Asn Cys Ser Val His Glu Cys Cys Glu Cys Leu 
                165                 170                 175     


Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr Leu Leu Met Cys Leu 
            180                 185                 190         


Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser Pro Leu Met Ser Val 
        195                 200                 205             


Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro Leu Gly Leu His Met 
    210                 215                 220                 


Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser Trp Ser Ser Pro Pro 
225                 230                 235                 240 


Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys Tyr Ser Glu Asn Ser 
                245                 250                 255     


Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val Ser Ala Thr Ser Leu 
            260                 265                 270         


Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr Glu Val Gln Val Arg 
        275                 280                 285             


Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser Asp Trp Ser Thr Pro 
    290                 295                 300                 


Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe Pro Pro Lys Ile Leu 
305                 310                 315                 320 


Thr Ser Val Gly Ser Asn Val Ser Phe His Cys Ile Tyr Lys Lys Glu 
                325                 330                 335     


Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp Trp Met Asn Leu Ala 
            340                 345                 350         


Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val Ser Asp His Val Ser 
        355                 360                 365             


Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys Pro Arg Gly Lys Phe 
    370                 375                 380                 


Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His Glu Cys His His Arg 
385                 390                 395                 400 


Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile Asn Ile Ser Cys Glu 
                405                 410                 415     


Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg Trp Ser Thr Ser Thr 
            420                 425                 430         


Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu Arg Tyr His Arg Ser 
        435                 440                 445             


Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His Pro Ile Ser Glu Pro 
    450                 455                 460                 


Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr Glu Cys Ile Phe Gln 
465                 470                 475                 480 


Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp Ile Arg Ile Asn His 
                485                 490                 495     


Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys Val Leu Pro Asp Ser 
            500                 505                 510         


Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys Ala Glu Ile Thr Ile 
        515                 520                 525             


Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys Pro Val Phe Pro Glu 
    530                 535                 540                 


Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu Ser Gly Lys Glu Val 
545                 550                 555                 560 


Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys Ser Lys Ser Val Ser 
                565                 570                 575     


Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala Val Gln Val Arg Cys 
            580                 585                 590         


Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn Trp Ser Asn Pro Ala 
        595                 600                 605             


Tyr Thr Val Val Met Asp Ile Lys Val Pro Met Arg Gly Pro Glu Phe 
    610                 615                 620                 


Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys Glu Lys Asn Val Thr 
625                 630                 635                 640 


Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser Leu Cys Ser Val Gln 
                645                 650                 655     


Arg Tyr Val Ile Asn His His Thr Ser Cys Asn Gly Thr Trp Ser Glu 
            660                 665                 670         


Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu Trp Thr Glu Gln Ala 
        675                 680                 685             


His Thr Val Thr Val Leu Ala Ile Asn Ser Ile Gly Ala Ser Val Ala 
    690                 695                 700                 


Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser Lys Val Asn Ile Val 
705                 710                 715                 720 


Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser Cys Val Ile Val Ser 
                725                 730                 735     


Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met Tyr Phe Ile Ile Glu 
            740                 745                 750         


Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys Trp Leu Arg Ile Ser 
        755                 760                 765             


Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His Phe Ile Pro Ile Glu 
    770                 775                 780                 


Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met Glu Gly Val Gly Lys 
785                 790                 795                 800 


Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp Ile Glu Lys His Gln 
                805                 810                 815     


Ser Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            820                 825                 830         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        835                 840                 845             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    850                 855                 860                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
865                 870                 875                 880 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                885                 890                 895     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            900                 905                 910         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        915                 920                 925             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    930                 935                 940                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
945                 950                 955                 960 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                965                 970                 975     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            980                 985                 990         


Pro Pro Val Leu Asp Ser Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu 
        995                 1000                 1005             


Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys 
    1010                 1015                 1020             


Ser Val  Met His Glu Ala Leu  His Asn His Tyr Thr  Gln Lys Ser 
    1025                 1030                 1035             


Leu Ser  Leu Ser Pro Gly Lys  
    1040                 1045 


<210>  117
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MfLEPR.mmh aa 1-816: Macaca fascicularis F22-D837 with a T827A 
       substitution from XP_005543194.1 aa 817-844: 
       myc-myc-hexahistidine tag

<400>  117

Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg Phe Lys Leu Ser Cys 
1               5                   10                  15      


Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu Leu Pro Ala Gly Leu 
            20                  25                  30          


Ser Lys Asn Thr Ser Asn Leu Asn Gly His Tyr Glu Thr Ala Val Glu 
        35                  40                  45              


Phe Asn Ser Ser Asp Thr His Phe Ser Asn Leu Ser Lys Thr Thr Phe 
    50                  55                  60                  


His Cys Cys Phe Arg Ser Glu Gln Asp Arg Asn Cys Ser Leu Cys Ala 
65                  70                  75                  80  


Asp Asn Ile Glu Gly Lys Thr Phe Val Ser Thr Val Asn Ser Ser Val 
                85                  90                  95      


Phe Gln Gln Met Gly Ala Asn Trp Asn Ile Gln Cys Trp Leu Lys Gly 
            100                 105                 110         


Asp Leu Lys Leu Phe Ile Cys Tyr Val Glu Ser Leu Phe Lys Asn Pro 
        115                 120                 125             


Phe Lys Asn Tyr Lys His Lys Val His Leu Leu Tyr Val Leu Pro Glu 
    130                 135                 140                 


Val Leu Glu Asp Ser Pro Leu Val Pro Gln Lys Gly Ser Phe Gln Met 
145                 150                 155                 160 


Val His Cys Asn Cys Ser Val His Glu Arg Cys Glu Cys Leu Val Pro 
                165                 170                 175     


Val Pro Thr Ala Lys Leu Asn Asp Thr Leu Leu Met Cys Leu Lys Ile 
            180                 185                 190         


Thr Ser Gly Gly Val Ile Phe Gln Ser Pro Leu Met Ser Val Gln Pro 
        195                 200                 205             


Ile Asn Met Val Lys Pro Asp Pro Pro Leu Gly Leu Arg Met Glu Ile 
    210                 215                 220                 


Thr Asp Asp Gly Asn Leu Lys Ile Ser Trp Ser Ser Pro Pro Leu Val 
225                 230                 235                 240 


Pro Phe Pro Leu Gln Tyr Glu Val Lys Tyr Ser Glu Asn Ser Thr Thr 
                245                 250                 255     


Val Ile Arg Glu Ala Asp Lys Ile Val Ser Ala Thr Ser Leu Leu Val 
            260                 265                 270         


Asp Gly Ile Leu Pro Gly Ser Ser Tyr Glu Val Gln Val Arg Gly Lys 
        275                 280                 285             


Arg Leu Asp Gly Pro Gly Ile Trp Ser Asp Trp Ser Thr Pro His Val 
    290                 295                 300                 


Phe Thr Thr Gln Asp Val Ile Tyr Phe Pro Pro Lys Ile Leu Thr Ser 
305                 310                 315                 320 


Val Gly Ser Asn Val Ser Phe His Cys Ile Tyr Lys Asn Glu Asn Lys 
                325                 330                 335     


Ile Val Ser Ser Lys Lys Ile Val Trp Trp Met Asn Leu Ala Glu Lys 
            340                 345                 350         


Ile Pro Gln Ser Gln Tyr Asp Val Val Ser Asp His Val Ser Lys Val 
        355                 360                 365             


Thr Phe Phe Asn Leu Asn Glu Thr Lys Pro Arg Gly Lys Phe Thr Tyr 
    370                 375                 380                 


Asp Ala Val Tyr Cys Cys Asn Glu His Glu Cys His His Arg Tyr Ala 
385                 390                 395                 400 


Glu Leu Tyr Val Ile Asp Val Asn Ile Asn Ile Ser Cys Glu Thr Asp 
                405                 410                 415     


Gly His Leu Thr Lys Met Thr Cys Arg Trp Ser Thr Asn Thr Ile Gln 
            420                 425                 430         


Ser Leu Ala Gly Ser Thr Leu Gln Leu Arg Tyr Arg Arg Ser Ser Leu 
        435                 440                 445             


Tyr Cys Phe Asp Ile Pro Ser Ile His Pro Ile Ser Lys Pro Lys Asp 
    450                 455                 460                 


Cys Tyr Leu Gln Ser Asp Gly Phe Tyr Glu Cys Val Phe Gln Pro Ile 
465                 470                 475                 480 


Phe Leu Leu Ser Gly Tyr Thr Met Trp Ile Arg Ile Asn His Pro Leu 
                485                 490                 495     


Gly Ser Leu Asp Ser Pro Pro Thr Cys Val Leu Pro Asp Ser Val Val 
            500                 505                 510         


Lys Pro Leu Pro Pro Ser Ser Val Lys Ala Glu Ile Ile Lys Asn Ile 
        515                 520                 525             


Gly Leu Leu Lys Ile Ser Trp Glu Lys Pro Val Phe Pro Glu Asn Asn 
    530                 535                 540                 


Leu Gln Phe Gln Ile Arg Tyr Gly Leu Ser Gly Lys Glu Ile Gln Trp 
545                 550                 555                 560 


Lys Met Tyr Asp Val Tyr Asp Ala Lys Ser Lys Ser Val Ser Leu Pro 
                565                 570                 575     


Val Pro Asp Phe Cys Ala Val Tyr Ala Val Gln Val Arg Cys Lys Arg 
            580                 585                 590         


Ser Asp Gly Leu Gly Leu Trp Ser Asn Trp Ser Asn Pro Ala Tyr Thr 
        595                 600                 605             


Val Val Met Asp Ile Lys Val Pro Met Arg Gly Pro Glu Phe Trp Arg 
    610                 615                 620                 


Ile Ile Asn Gly Asp Thr Met Lys Lys Glu Lys Asn Val Thr Leu Leu 
625                 630                 635                 640 


Trp Lys Pro Leu Met Lys Asn Asp Ser Leu Cys Ser Val Gln Arg Tyr 
                645                 650                 655     


Val Ile Asn His His Thr Ser Cys Asn Gly Thr Trp Ser Glu Asp Val 
            660                 665                 670         


Gly Asn His Thr Lys Phe Thr Phe Leu Trp Thr Glu Gln Ala His Thr 
        675                 680                 685             


Val Thr Val Leu Ala Ile Asn Ser Ile Gly Ala Ser Val Ala Asn Phe 
    690                 695                 700                 


Asn Leu Thr Phe Ser Trp Pro Met Ser Lys Val Asn Ile Val Gln Ser 
705                 710                 715                 720 


Leu Ser Ala Tyr Pro Leu Asn Ser Ser Cys Val Ile Leu Ser Trp Ile 
                725                 730                 735     


Leu Ser Pro Ser Asp Tyr Lys Leu Met Tyr Phe Ile Ile Glu Trp Lys 
            740                 745                 750         


Asn Leu Asn Glu Asp Gly Glu Ile Lys Trp Leu Arg Ile Ser Ser Ser 
        755                 760                 765             


Val Lys Lys Tyr Tyr Ile His Asp His Phe Ile Pro Ile Glu Lys Tyr 
    770                 775                 780                 


Gln Phe Ser Leu Tyr Pro Ile Phe Met Glu Gly Val Gly Lys Pro Lys 
785                 790                 795                 800 


Ile Ile Asn Ser Phe Ala Gln Asp Asn Thr Glu Lys His Gln Asn Asp 
                805                 810                 815     


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln Lys Leu 
            820                 825                 830         


Ile Ser Glu Glu Asp Leu His His His His His His 
        835                 840                 


<210>  118
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mLEPR.mmh aa 1-818: Mouse LEPR (L22-G839 of NP_666258.2) aa 
       817-846: myc-myc-hexahistidine tag

<400>  118

Leu Asn Leu Ala Tyr Pro Ile Ser Pro Trp Lys Phe Lys Leu Phe Cys 
1               5                   10                  15      


Gly Pro Pro Asn Thr Thr Asp Asp Ser Phe Leu Ser Pro Ala Gly Ala 
            20                  25                  30          


Pro Asn Asn Ala Ser Ala Leu Lys Gly Ala Ser Glu Ala Ile Val Glu 
        35                  40                  45              


Ala Lys Phe Asn Ser Ser Gly Ile Tyr Val Pro Glu Leu Ser Lys Thr 
    50                  55                  60                  


Val Phe His Cys Cys Phe Gly Asn Glu Gln Gly Gln Asn Cys Ser Ala 
65                  70                  75                  80  


Leu Thr Asp Asn Thr Glu Gly Lys Thr Leu Ala Ser Val Val Lys Ala 
                85                  90                  95      


Ser Val Phe Arg Gln Leu Gly Val Asn Trp Asp Ile Glu Cys Trp Met 
            100                 105                 110         


Lys Gly Asp Leu Thr Leu Phe Ile Cys His Met Glu Pro Leu Pro Lys 
        115                 120                 125             


Asn Pro Phe Lys Asn Tyr Asp Ser Lys Val His Leu Leu Tyr Asp Leu 
    130                 135                 140                 


Pro Glu Val Ile Asp Asp Ser Pro Leu Pro Pro Leu Lys Asp Ser Phe 
145                 150                 155                 160 


Gln Thr Val Gln Cys Asn Cys Ser Leu Arg Gly Cys Glu Cys His Val 
                165                 170                 175     


Pro Val Pro Arg Ala Lys Leu Asn Tyr Ala Leu Leu Met Tyr Leu Glu 
            180                 185                 190         


Ile Thr Ser Ala Gly Val Ser Phe Gln Ser Pro Leu Met Ser Leu Gln 
        195                 200                 205             


Pro Met Leu Val Val Lys Pro Asp Pro Pro Leu Gly Leu His Met Glu 
    210                 215                 220                 


Val Thr Asp Asp Gly Asn Leu Lys Ile Ser Trp Asp Ser Gln Thr Met 
225                 230                 235                 240 


Ala Pro Phe Pro Leu Gln Tyr Gln Val Lys Tyr Leu Glu Asn Ser Thr 
                245                 250                 255     


Ile Val Arg Glu Ala Ala Glu Ile Val Ser Ala Thr Ser Leu Leu Val 
            260                 265                 270         


Asp Ser Val Leu Pro Gly Ser Ser Tyr Glu Val Gln Val Arg Ser Lys 
        275                 280                 285             


Arg Leu Asp Gly Ser Gly Val Trp Ser Asp Trp Ser Ser Pro Gln Val 
    290                 295                 300                 


Phe Thr Thr Gln Asp Val Val Tyr Phe Pro Pro Lys Ile Leu Thr Ser 
305                 310                 315                 320 


Val Gly Ser Asn Ala Ser Phe His Cys Ile Tyr Lys Asn Glu Asn Gln 
                325                 330                 335     


Ile Ile Ser Ser Lys Gln Ile Val Trp Trp Arg Asn Leu Ala Glu Lys 
            340                 345                 350         


Ile Pro Glu Ile Gln Tyr Ser Ile Val Ser Asp Arg Val Ser Lys Val 
        355                 360                 365             


Thr Phe Ser Asn Leu Lys Ala Thr Arg Pro Arg Gly Lys Phe Thr Tyr 
    370                 375                 380                 


Asp Ala Val Tyr Cys Cys Asn Glu Gln Ala Cys His His Arg Tyr Ala 
385                 390                 395                 400 


Glu Leu Tyr Val Ile Asp Val Asn Ile Asn Ile Ser Cys Glu Thr Asp 
                405                 410                 415     


Gly Tyr Leu Thr Lys Met Thr Cys Arg Trp Ser Pro Ser Thr Ile Gln 
            420                 425                 430         


Ser Leu Val Gly Ser Thr Val Gln Leu Arg Tyr His Arg Arg Ser Leu 
        435                 440                 445             


Tyr Cys Pro Asp Ser Pro Ser Ile His Pro Thr Ser Glu Pro Lys Asn 
    450                 455                 460                 


Cys Val Leu Gln Arg Asp Gly Phe Tyr Glu Cys Val Phe Gln Pro Ile 
465                 470                 475                 480 


Phe Leu Leu Ser Gly Tyr Thr Met Trp Ile Arg Ile Asn His Ser Leu 
                485                 490                 495     


Gly Ser Leu Asp Ser Pro Pro Thr Cys Val Leu Pro Asp Ser Val Val 
            500                 505                 510         


Lys Pro Leu Pro Pro Ser Asn Val Lys Ala Glu Ile Thr Val Asn Thr 
        515                 520                 525             


Gly Leu Leu Lys Val Ser Trp Glu Lys Pro Val Phe Pro Glu Asn Asn 
    530                 535                 540                 


Leu Gln Phe Gln Ile Arg Tyr Gly Leu Ser Gly Lys Glu Ile Gln Trp 
545                 550                 555                 560 


Lys Thr His Glu Val Phe Asp Ala Lys Ser Lys Ser Ala Ser Leu Leu 
                565                 570                 575     


Val Ser Asp Leu Cys Ala Val Tyr Val Val Gln Val Arg Cys Arg Arg 
            580                 585                 590         


Leu Asp Gly Leu Gly Tyr Trp Ser Asn Trp Ser Ser Pro Ala Tyr Thr 
        595                 600                 605             


Leu Val Met Asp Val Lys Val Pro Met Arg Gly Pro Glu Phe Trp Arg 
    610                 615                 620                 


Lys Met Asp Gly Asp Val Thr Lys Lys Glu Arg Asn Val Thr Leu Leu 
625                 630                 635                 640 


Trp Lys Pro Leu Thr Lys Asn Asp Ser Leu Cys Ser Val Arg Arg Tyr 
                645                 650                 655     


Val Val Lys His Arg Thr Ala His Asn Gly Thr Trp Ser Glu Asp Val 
            660                 665                 670         


Gly Asn Arg Thr Asn Leu Thr Phe Leu Trp Thr Glu Pro Ala His Thr 
        675                 680                 685             


Val Thr Val Leu Ala Val Asn Ser Leu Gly Ala Ser Leu Val Asn Phe 
    690                 695                 700                 


Asn Leu Thr Phe Ser Trp Pro Met Ser Lys Val Ser Ala Val Glu Ser 
705                 710                 715                 720 


Leu Ser Ala Tyr Pro Leu Ser Ser Ser Cys Val Ile Leu Ser Trp Thr 
                725                 730                 735     


Leu Ser Pro Asp Asp Tyr Ser Leu Leu Tyr Leu Val Ile Glu Trp Lys 
            740                 745                 750         


Ile Leu Asn Glu Asp Asp Gly Met Lys Trp Leu Arg Ile Pro Ser Asn 
        755                 760                 765             


Val Lys Lys Phe Tyr Ile His Asp Asn Phe Ile Pro Ile Glu Lys Tyr 
    770                 775                 780                 


Gln Phe Ser Leu Tyr Pro Val Phe Met Glu Gly Val Gly Lys Pro Lys 
785                 790                 795                 800 


Ile Ile Asn Gly Phe Thr Lys Asp Ala Ile Asp Lys Gln Gln Asn Asp 
                805                 810                 815     


Ala Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln 
            820                 825                 830         


Lys Leu Ile Ser Glu Glu Asp Leu His His His His His His 
        835                 840                 845     


<210>  119
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rLEPR.mmh aa 1-818: Rat LEPR (L22-G839 of NP_036728.1) aa 
       819-846: myc-myc-hexahistidine tag

<400>  119

Leu Asn Leu Ala Tyr Pro Thr Ser Pro Trp Arg Phe Lys Leu Phe Cys 
1               5                   10                  15      


Ala Pro Pro Ser Thr Thr Asp Asp Ser Phe Leu Ser Pro Ala Gly Val 
            20                  25                  30          


Pro Asn Asn Thr Ser Ser Leu Lys Gly Ala Ser Glu Ala Leu Val Glu 
        35                  40                  45              


Ala Lys Phe Asn Ser Thr Gly Ile Tyr Val Ser Glu Leu Ser Lys Thr 
    50                  55                  60                  


Ile Phe His Cys Cys Phe Gly Asn Glu Gln Gly Gln Asn Cys Ser Ala 
65                  70                  75                  80  


Leu Thr Gly Asn Thr Glu Gly Lys Thr Leu Ala Ser Val Val Lys Pro 
                85                  90                  95      


Leu Val Phe Arg Gln Leu Gly Val Asn Trp Asp Ile Glu Cys Trp Met 
            100                 105                 110         


Lys Gly Asp Leu Thr Leu Phe Ile Cys His Met Glu Pro Leu Leu Lys 
        115                 120                 125             


Asn Pro Phe Lys Asn Tyr Asp Ser Lys Val His Leu Leu Tyr Asp Leu 
    130                 135                 140                 


Pro Glu Val Ile Asp Asp Leu Pro Leu Pro Pro Leu Lys Asp Ser Phe 
145                 150                 155                 160 


Gln Thr Val Gln Cys Asn Cys Ser Val Arg Glu Cys Glu Cys His Val 
                165                 170                 175     


Pro Val Pro Arg Ala Lys Val Asn Tyr Ala Leu Leu Met Tyr Leu Glu 
            180                 185                 190         


Ile Thr Ser Ala Gly Val Ser Phe Gln Ser Pro Leu Met Ser Leu Gln 
        195                 200                 205             


Pro Met Leu Val Val Lys Pro Asp Pro Pro Leu Gly Leu Arg Met Glu 
    210                 215                 220                 


Val Thr Asp Asp Gly Asn Leu Lys Ile Ser Trp Asp Ser Gln Thr Lys 
225                 230                 235                 240 


Ala Pro Phe Pro Leu Gln Tyr Gln Val Lys Tyr Leu Glu Asn Ser Thr 
                245                 250                 255     


Ile Val Arg Glu Ala Ala Glu Ile Val Ser Asp Thr Ser Leu Leu Val 
            260                 265                 270         


Asp Ser Val Leu Pro Gly Ser Ser Tyr Glu Val Gln Val Arg Ser Lys 
        275                 280                 285             


Arg Leu Asp Gly Ser Gly Val Trp Ser Asp Trp Ser Leu Pro Gln Leu 
    290                 295                 300                 


Phe Thr Thr Gln Asp Val Met Tyr Phe Pro Pro Lys Ile Leu Thr Ser 
305                 310                 315                 320 


Val Gly Ser Asn Ala Ser Phe Cys Cys Ile Tyr Lys Asn Glu Asn Gln 
                325                 330                 335     


Thr Ile Ser Ser Lys Gln Ile Val Trp Trp Met Asn Leu Ala Glu Lys 
            340                 345                 350         


Ile Pro Glu Thr Gln Tyr Asn Thr Val Ser Asp His Ile Ser Lys Val 
        355                 360                 365             


Thr Phe Ser Asn Leu Lys Ala Thr Arg Pro Arg Gly Lys Phe Thr Tyr 
    370                 375                 380                 


Asp Ala Val Tyr Cys Cys Asn Glu Gln Ala Cys His His Arg Tyr Ala 
385                 390                 395                 400 


Glu Leu Tyr Val Ile Asp Val Asn Ile Asn Ile Ser Cys Glu Thr Asp 
                405                 410                 415     


Gly Tyr Leu Thr Lys Met Thr Cys Arg Trp Ser Pro Ser Thr Ile Gln 
            420                 425                 430         


Ser Leu Val Gly Ser Thr Val Gln Leu Arg Tyr His Arg Arg Ser Leu 
        435                 440                 445             


Tyr Cys Pro Asp Asn Pro Ser Ile Arg Pro Thr Ser Glu Leu Lys Asn 
    450                 455                 460                 


Cys Val Leu Gln Thr Asp Gly Phe Tyr Glu Cys Val Phe Gln Pro Ile 
465                 470                 475                 480 


Phe Leu Leu Ser Gly Tyr Thr Met Trp Ile Arg Ile Asn His Ser Leu 
                485                 490                 495     


Gly Ser Leu Asp Ser Pro Pro Thr Cys Val Leu Pro Asp Ser Val Val 
            500                 505                 510         


Lys Pro Leu Pro Pro Ser Asn Val Lys Ala Glu Ile Thr Ile Asn Thr 
        515                 520                 525             


Gly Leu Leu Lys Val Ser Trp Glu Lys Pro Val Phe Pro Glu Asn Asn 
    530                 535                 540                 


Leu Gln Phe Gln Ile Arg Tyr Gly Leu Asn Gly Lys Glu Ile Gln Trp 
545                 550                 555                 560 


Lys Thr His Glu Val Phe Asp Ala Lys Ser Lys Ser Ala Ser Leu Pro 
                565                 570                 575     


Val Ser Asp Leu Cys Ala Val Tyr Val Val Gln Val Arg Cys Arg Arg 
            580                 585                 590         


Leu Asp Gly Leu Gly Tyr Trp Ser Asn Trp Ser Ser Pro Ala Tyr Thr 
        595                 600                 605             


Leu Val Met Asp Val Lys Val Pro Met Arg Gly Pro Glu Phe Trp Arg 
    610                 615                 620                 


Ile Met Asp Gly Asp Ile Thr Lys Lys Glu Arg Asn Val Thr Leu Leu 
625                 630                 635                 640 


Trp Lys Pro Leu Met Lys Asn Asp Ser Leu Cys Ser Val Arg Arg Tyr 
                645                 650                 655     


Val Val Lys His Arg Thr Ala His Asn Gly Thr Trp Ser Gln Asp Val 
            660                 665                 670         


Gly Asn Gln Thr Asn Leu Thr Phe Leu Trp Ala Glu Ser Ala His Thr 
        675                 680                 685             


Val Thr Val Leu Ala Ile Asn Ser Ile Gly Ala Ser Leu Val Asn Phe 
    690                 695                 700                 


Asn Leu Thr Phe Ser Trp Pro Met Ser Lys Val Asn Ala Val Gln Ser 
705                 710                 715                 720 


Leu Ser Ala Tyr Pro Leu Ser Ser Ser Cys Val Ile Leu Ser Trp Thr 
                725                 730                 735     


Leu Ser Pro Asn Asp Tyr Ser Leu Leu Tyr Leu Val Ile Glu Trp Lys 
            740                 745                 750         


Asn Leu Asn Asp Asp Asp Gly Met Lys Trp Leu Arg Ile Pro Ser Asn 
        755                 760                 765             


Val Asn Lys Tyr Tyr Ile His Asp Asn Phe Ile Pro Ile Glu Lys Tyr 
    770                 775                 780                 


Gln Phe Ser Leu Tyr Pro Val Phe Met Glu Gly Val Gly Lys Pro Lys 
785                 790                 795                 800 


Ile Ile Asn Gly Phe Thr Lys Asp Asp Ile Ala Lys Gln Gln Asn Asp 
                805                 810                 815     


Ala Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln 
            820                 825                 830         


Lys Leu Ile Ser Glu Glu Asp Leu His His His His His His 
        835                 840                 845     


<210>  120
<211>  1045
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mLEPR.hFc aa 1-818: Mouse LEPR (L22-G839 of NP_666258.2) aa 
       819-1045: human IgG1 tag (D104-K330 of P01857)

<400>  120

Leu Asn Leu Ala Tyr Pro Ile Ser Pro Trp Lys Phe Lys Leu Phe Cys 
1               5                   10                  15      


Gly Pro Pro Asn Thr Thr Asp Asp Ser Phe Leu Ser Pro Ala Gly Ala 
            20                  25                  30          


Pro Asn Asn Ala Ser Ala Leu Lys Gly Ala Ser Glu Ala Ile Val Glu 
        35                  40                  45              


Ala Lys Phe Asn Ser Ser Gly Ile Tyr Val Pro Glu Leu Ser Lys Thr 
    50                  55                  60                  


Val Phe His Cys Cys Phe Gly Asn Glu Gln Gly Gln Asn Cys Ser Ala 
65                  70                  75                  80  


Leu Thr Asp Asn Thr Glu Gly Lys Thr Leu Ala Ser Val Val Lys Ala 
                85                  90                  95      


Ser Val Phe Arg Gln Leu Gly Val Asn Trp Asp Ile Glu Cys Trp Met 
            100                 105                 110         


Lys Gly Asp Leu Thr Leu Phe Ile Cys His Met Glu Pro Leu Pro Lys 
        115                 120                 125             


Asn Pro Phe Lys Asn Tyr Asp Ser Lys Val His Leu Leu Tyr Asp Leu 
    130                 135                 140                 


Pro Glu Val Ile Asp Asp Ser Pro Leu Pro Pro Leu Lys Asp Ser Phe 
145                 150                 155                 160 


Gln Thr Val Gln Cys Asn Cys Ser Leu Arg Gly Cys Glu Cys His Val 
                165                 170                 175     


Pro Val Pro Arg Ala Lys Leu Asn Tyr Ala Leu Leu Met Tyr Leu Glu 
            180                 185                 190         


Ile Thr Ser Ala Gly Val Ser Phe Gln Ser Pro Leu Met Ser Leu Gln 
        195                 200                 205             


Pro Met Leu Val Val Lys Pro Asp Pro Pro Leu Gly Leu His Met Glu 
    210                 215                 220                 


Val Thr Asp Asp Gly Asn Leu Lys Ile Ser Trp Asp Ser Gln Thr Met 
225                 230                 235                 240 


Ala Pro Phe Pro Leu Gln Tyr Gln Val Lys Tyr Leu Glu Asn Ser Thr 
                245                 250                 255     


Ile Val Arg Glu Ala Ala Glu Ile Val Ser Ala Thr Ser Leu Leu Val 
            260                 265                 270         


Asp Ser Val Leu Pro Gly Ser Ser Tyr Glu Val Gln Val Arg Ser Lys 
        275                 280                 285             


Arg Leu Asp Gly Ser Gly Val Trp Ser Asp Trp Ser Ser Pro Gln Val 
    290                 295                 300                 


Phe Thr Thr Gln Asp Val Val Tyr Phe Pro Pro Lys Ile Leu Thr Ser 
305                 310                 315                 320 


Val Gly Ser Asn Ala Ser Phe His Cys Ile Tyr Lys Asn Glu Asn Gln 
                325                 330                 335     


Ile Ile Ser Ser Lys Gln Ile Val Trp Trp Arg Asn Leu Ala Glu Lys 
            340                 345                 350         


Ile Pro Glu Ile Gln Tyr Ser Ile Val Ser Asp Arg Val Ser Lys Val 
        355                 360                 365             


Thr Phe Ser Asn Leu Lys Ala Thr Arg Pro Arg Gly Lys Phe Thr Tyr 
    370                 375                 380                 


Asp Ala Val Tyr Cys Cys Asn Glu Gln Ala Cys His His Arg Tyr Ala 
385                 390                 395                 400 


Glu Leu Tyr Val Ile Asp Val Asn Ile Asn Ile Ser Cys Glu Thr Asp 
                405                 410                 415     


Gly Tyr Leu Thr Lys Met Thr Cys Arg Trp Ser Pro Ser Thr Ile Gln 
            420                 425                 430         


Ser Leu Val Gly Ser Thr Val Gln Leu Arg Tyr His Arg Arg Ser Leu 
        435                 440                 445             


Tyr Cys Pro Asp Ser Pro Ser Ile His Pro Thr Ser Glu Pro Lys Asn 
    450                 455                 460                 


Cys Val Leu Gln Arg Asp Gly Phe Tyr Glu Cys Val Phe Gln Pro Ile 
465                 470                 475                 480 


Phe Leu Leu Ser Gly Tyr Thr Met Trp Ile Arg Ile Asn His Ser Leu 
                485                 490                 495     


Gly Ser Leu Asp Ser Pro Pro Thr Cys Val Leu Pro Asp Ser Val Val 
            500                 505                 510         


Lys Pro Leu Pro Pro Ser Asn Val Lys Ala Glu Ile Thr Val Asn Thr 
        515                 520                 525             


Gly Leu Leu Lys Val Ser Trp Glu Lys Pro Val Phe Pro Glu Asn Asn 
    530                 535                 540                 


Leu Gln Phe Gln Ile Arg Tyr Gly Leu Ser Gly Lys Glu Ile Gln Trp 
545                 550                 555                 560 


Lys Thr His Glu Val Phe Asp Ala Lys Ser Lys Ser Ala Ser Leu Leu 
                565                 570                 575     


Val Ser Asp Leu Cys Ala Val Tyr Val Val Gln Val Arg Cys Arg Arg 
            580                 585                 590         


Leu Asp Gly Leu Gly Tyr Trp Ser Asn Trp Ser Ser Pro Ala Tyr Thr 
        595                 600                 605             


Leu Val Met Asp Val Lys Val Pro Met Arg Gly Pro Glu Phe Trp Arg 
    610                 615                 620                 


Lys Met Asp Gly Asp Val Thr Lys Lys Glu Arg Asn Val Thr Leu Leu 
625                 630                 635                 640 


Trp Lys Pro Leu Thr Lys Asn Asp Ser Leu Cys Ser Val Arg Arg Tyr 
                645                 650                 655     


Val Val Lys His Arg Thr Ala His Asn Gly Thr Trp Ser Glu Asp Val 
            660                 665                 670         


Gly Asn Arg Thr Asn Leu Thr Phe Leu Trp Thr Glu Pro Ala His Thr 
        675                 680                 685             


Val Thr Val Leu Ala Val Asn Ser Leu Gly Ala Ser Leu Val Asn Phe 
    690                 695                 700                 


Asn Leu Thr Phe Ser Trp Pro Met Ser Lys Val Ser Ala Val Glu Ser 
705                 710                 715                 720 


Leu Ser Ala Tyr Pro Leu Ser Ser Ser Cys Val Ile Leu Ser Trp Thr 
                725                 730                 735     


Leu Ser Pro Asp Asp Tyr Ser Leu Leu Tyr Leu Val Ile Glu Trp Lys 
            740                 745                 750         


Ile Leu Asn Glu Asp Asp Gly Met Lys Trp Leu Arg Ile Pro Ser Asn 
        755                 760                 765             


Val Lys Lys Phe Tyr Ile His Asp Asn Phe Ile Pro Ile Glu Lys Tyr 
    770                 775                 780                 


Gln Phe Ser Leu Tyr Pro Val Phe Met Glu Gly Val Gly Lys Pro Lys 
785                 790                 795                 800 


Ile Ile Asn Gly Phe Thr Lys Asp Ala Ile Asp Lys Gln Gln Asn Asp 
                805                 810                 815     


Ala Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            820                 825                 830         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        835                 840                 845             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    850                 855                 860                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
865                 870                 875                 880 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                885                 890                 895     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            900                 905                 910         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        915                 920                 925             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    930                 935                 940                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
945                 950                 955                 960 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                965                 970                 975     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            980                 985                 990         


Pro Pro Val Leu Asp Ser Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu 
        995                 1000                 1005             


Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys 
    1010                 1015                 1020             


Ser Val  Met His Glu Ala Leu  His Asn His Tyr Thr  Gln Lys Ser 
    1025                 1030                 1035             


Leu Ser  Leu Ser Pro Gly Lys  
    1040                 1045 


