                         SEQUENCE LISTING

<110>  DINGFU BIOTARGET CO.,LTD.
 
<120>  ANTI-CD27 ANTIBODIES AND USE THEREOF

<130>  0027-PA-020

<160>  152   

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 VH

<400>  1

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Ser 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asp Ser Gly Phe Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Arg Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ser Tyr Tyr Asp Thr Ser Tyr Thr Ser Met Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Asn Ser Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1A8 VH nucleotide

<400>  2
gaggtgcagc tgcaggagtc tggggctgaa ttggtaaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta cagtttcacc agctcctgga tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggaatg attcatcctg atagtggttt tactaactac      180

aatgagaagt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcgcctca gcagcctgac atctgaggac tctgcggtct attactgtgc aaggacctct      300

tactacgata ctagctacac ttctatggac ttctggggtc aaggaaactc agtcaccgtc      360

tcctca                                                                 366


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8VL

<400>  3

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  4
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1A8VL nucleotide

<400>  4
gatattgtgc tgacccagtc tccagccatc ctgtctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gagcattggc acaagcatac attggtatca gcaaagaaca      120

aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct      240

gaagatattg cagattatta ctgtcaacaa agtaatagct ggccactcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 HCDR1

<400>  5

Ser Ser Trp Met His 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 HCDR2

<400>  6

Met Ile His Pro Asp Ser Gly Phe Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 HCDR3

<400>  7

Thr Ser Tyr Tyr Asp Thr Ser Tyr Thr Ser Met Asp Phe 
1               5                   10              


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 LCDR1

<400>  8

Arg Ala Ser Gln Ser Ile Gly Thr Ser Ile His 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 LCDR2

<400>  9

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 LCDR3

<400>  10

Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   


<210>  11
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8 VH

<400>  11

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asn Thr Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Tyr Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Arg Thr Asp Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Val Arg Glu Leu Gly Leu Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  12
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B8 VH nucleotide

<400>  12
gaggtgcagc tgcaggagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc       60

tcatgtgcag cctctggatt caacttcaat acctacacca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagatata aaagtaataa ttatgcaaca      180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc agaaagcatc      240

ctctatctgc aaatgaacaa cttgagaact gacgacacag ccatttattt ctgtgtgagg      300

gaactgggac tgtggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8VL

<400>  13

Asp Ile Val Met Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Arg Glu Lys Pro Gly Lys Thr Asn Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  14
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B8VL nucleotide

<400>  14
gacattgtga tgacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact       60

ataaattgca gggcaagtaa gagcattagc aaatatttag cctggtatcg agagaaacct      120

gggaaaacta ataatcttct tatctactct ggatccactt tgcaatctgg aattccatca      180

aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtag cctggagcct      240

gaagattttg caatgtatta ctgtcaacag cataatgaat acccgctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8 HCDR1

<400>  15

Thr Tyr Thr Met Asn 
1               5   


<210>  16
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8 HCDR2

<400>  16

Arg Ile Arg Tyr Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8 HCDR3

<400>  17

Glu Leu Gly Leu Trp Tyr Phe Asp Val 
1               5                   


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8 LCDR1

<400>  18

Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8 LCDR2

<400>  19

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8 LCDR3

<400>  20

Gln Gln His Asn Glu Tyr Pro Leu Thr 
1               5                   


<210>  21
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2E7 VH

<400>  21

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Ser Gly Val Pro Thr Tyr Val Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Ser Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Thr Arg Glu Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  22
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2E7 VH nucleotide

<400>  22
gaggtgcagc tgcaggagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca acctatggaa tgagctgggt gaaacaggct      120

ccaggaaagg gtttacagtg gatgggctgg ataaacacca actctggagt gccaacctat      180

gttgaggact tcaagggacg gtttgccttc tctttggaat cctctgccaa cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctatat acttctgtac aagagagggg      300

gatgctctgg actactgggg tcaaggaacc tcagtcaccg tctcctca                   348


<210>  23
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2E7VL

<400>  23

Asp Ile Val Met Thr Gln Ser Thr Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Arg Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Arg Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asn Thr Pro Pro Phe 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  24
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2E7VL nucleotide

<400>  24
gatattgtga tgacacaatc tacagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc      120

acctccccca gaagatggat ttatgacaca tccagactgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtaataccc cacccttcac gttcggtgct      300

gggaccaagt tggagctgaa a                                                321


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2E7 HCDR1

<400>  25

Thr Tyr Gly Met Ser 
1               5   


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2E7 HCDR2

<400>  26

Trp Ile Asn Thr Asn Ser Gly Val Pro Thr Tyr Val Glu Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2E7 HCDR3

<400>  27

Glu Gly Asp Ala Leu Asp Tyr 
1               5           


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2E7 LCDR1

<400>  28

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2E7 LCDR2

<400>  29

Asp Thr Ser Arg Leu Ala Ser 
1               5           


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2E7 LCDR3

<400>  30

Gln Gln Trp Ser Asn Thr Pro Pro Phe Thr 
1               5                   10  


<210>  31
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E7 VH

<400>  31

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu His Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr His Ser Gly Ala Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Ile Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  32
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3E7 VH nucleotide

<400>  32
cagatccagc tggtgcagag cggaccagaa ctgaagaagc caggagagac agtcaagatc       60

tcctgcaagg cttctggata tacgttcaca acctatggaa tgagctgggt gaaacaggct      120

ccaggaaagg gtttgcactg gatgggctgg ataaacaccc actctggagc gccaacatat      180

gttgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgccttt      240

ttgcagatca acaacctcat aaatgaggac acggctacat atttctgtgc aagagagggg      300

gatgctctgg actactgggg tcaaggaacc tcagtcaccg tctcctca                   348


<210>  33
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E7VL

<400>  33

Asp Ile Val Met Thr Gln Thr Thr Ala Ile Met Ser Ala Phe Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Phe 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  34
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3E7VL nucleotide

<400>  34
gacattgtga tgacccaaac tacagcaatc atgtctgcat ttccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcaacat ggaggctgaa      240

gatgctgcca cttattattg ccagcagtgg agtcgtaacc cacccttcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E7 HCDR1

<400>  35

Thr Tyr Gly Met Ser 
1               5   


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E7 HCDR2

<400>  36

Trp Ile Asn Thr His Ser Gly Ala Pro Thr Tyr Val Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E7 HCDR3

<400>  37

Glu Gly Asp Ala Leu Asp Tyr 
1               5           


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E7 LCDR1

<400>  38

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E7 LCDR2

<400>  39

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E7 LCDR3

<400>  40

Gln Gln Trp Ser Arg Asn Pro Pro Phe Thr 
1               5                   10  


<210>  41
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B8 VH

<400>  41

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Thr Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ile Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Glu Gly Asp Tyr Gly Asp Tyr Val Gly Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  42
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3B8 VH nucleotide

<400>  42
caggtccagc tgcaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcactg tctcagggtt ctcattaacc aactatgctg taagctgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagta atatggggtg acgggaccac aaattatcat      180

tcagctctca tatccagact gattatcagc aaggataact ccaagagcca agttttctta      240

aaactgaaca gtctgcaaac tgatgacaca gccacgtact actgtgccaa agagggcgac      300

tatggtgact acgtaggctg gtttgcttac tggggccaag ggactctggt cactgtctct      360

gca                                                                    363


<210>  43
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B8VL

<400>  43

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Phe Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  44
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3B8VL nucleotide

<400>  44
gatatcgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagagccacc       60

atctcctgca gagccagtga aagtgttgaa tattatggca caagtttaat gcagtggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa cgtagaatct      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctgtggagg aggatgattt tgcaatgtat ttctgtcagc aaagtaggaa gattccttac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B8 HCDR1

<400>  45

Asn Tyr Ala Val Ser 
1               5   


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B8 HCDR2

<400>  46

Trp Gly Asp Gly Thr Thr Asn Tyr His Ser Ala Leu Ile Ser 
1               5                   10                  


<210>  47
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B8 HCDR3

<400>  47

Glu Gly Asp Tyr Gly Asp Tyr Val Gly Trp Phe Ala Tyr 
1               5                   10              


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B8 LCDR1

<400>  48

Arg Ala Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln 
1               5                   10                  15  


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B8 LCDR2

<400>  49

Ala Ala Ser Asn Val Glu Ser 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B8 LCDR3

<400>  50

Gln Gln Ser Arg Lys Ile Pro Tyr Thr 
1               5                   


<210>  51
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G1 VH

<400>  51

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Lys Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Asn Tyr Ala Thr Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Tyr Ser Tyr Tyr Ser Tyr Gly Gly Gly Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  52
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G1 VH nucleotide

<400>  52
caggtccagc tgcagcagtc cggacctgag ctggtgaagc ctggcgcttc agtgaagata       60

tcatgcaagg cttctggtta ctcattcact gcctacaaca tgaactgggt gaagcagagc      120

aagggaaaga gccttgagtg gattggacta attaatccta actatgccac gactagttac      180

aatcagaagt tcaaggacaa ggccacattg actgtggacc aatcttccag cacagcctac      240

atgcagctca acagcctgac atctgaggac tctgcagtct attactgtgc ctactatagt      300

tactatagtt acgggggggg atatgctatg gactactggg gtcaaggaac ctcagtcacc      360

gtctcctca                                                              369


<210>  53
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G1VL

<400>  53

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  54
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G1VL nucleotide

<400>  54
gatatcttgc tgacccaatc tccagccatc ctgtctgtga gtccaggaga aagagtcagt       60

ttttcctgca gggccagtca gagcattggc acaagcatac actggtatca gcaaagaaca      120

aatgggtctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttattctta gcatcaacag tgtggagtct      240

gaggatattg ctgattatta ctgtcagcaa agtaatagct ggccgtggac gttcggtgga      300

ggcaccaggc tggaaatcaa a                                                321


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G1 HCDR1

<400>  55

Ala Tyr Asn Met Asn 
1               5   


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G1 HCDR2

<400>  56

Leu Ile Asn Pro Asn Tyr Ala Thr Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  57
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G1 HCDR3

<400>  57

Tyr Ser Tyr Tyr Ser Tyr Gly Gly Gly Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G1 LCDR1

<400>  58

Arg Ala Ser Gln Ser Ile Gly Thr Ser Ile His 
1               5                   10      


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G1 LCDR2

<400>  59

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G1 LCDR3

<400>  60

Gln Gln Ser Asn Ser Trp Pro Trp Thr 
1               5                   


<210>  61
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H3 VH

<400>  61

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Asn Ile Asn Trp Val Lys Gln Thr Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Pro Asn Tyr Gly Thr Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asn Gly Asp Tyr Val Gly Tyr Ala Met Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  62
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4H3 VH nucleotide

<400>  62
caggtgcagc tgcagcagtc tggacctgag ctggtgaagc ctggcgcttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact gcctacaaca ttaactgggt gaagcagacc      120

aatggaaaga gccttgagtg gattggaata attaatccta actatggtac tactagttac      180

aaccagaagt tcaagggcaa ggccacattg actgtagacc aatcttccag tacagcctac      240

atgcagctca acagcctgac atctgaggac tctgcagtct attactgtgc aagacggaat      300

ggtgactacg tgggatatgc tatggactcc tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  63
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H3VL

<400>  63

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Met His Trp Tyr Gln Gln Arg Lys Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Thr Asn Asn Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Phe Lys 
            100                 105         


<210>  64
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4H3VL nucleotide

<400>  64
gatatcgttc tcacccagtc tccagccatc ctctctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gagcattggc acaagcatgc actggtatca gcaaagaaaa      120

aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct      240

gaggatattg cagattatta ctgtcaacaa actaataact ggccgtggac gttcggtgga      300

ggcaccaagc tggaattcaa a                                                321


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H3 HCDR1

<400>  65

Ala Tyr Asn Ile Asn 
1               5   


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H3 HCDR2

<400>  66

Ile Ile Asn Pro Asn Tyr Gly Thr Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H3 HCDR3

<400>  67

Arg Asn Gly Asp Tyr Val Gly Tyr Ala Met Asp Ser 
1               5                   10          


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H3 LCDR1

<400>  68

Arg Ala Ser Gln Ser Ile Gly Thr Ser Met His 
1               5                   10      


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H3 LCDR2

<400>  69

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H3 LCDR3

<400>  70

Gln Gln Thr Asn Asn Trp Pro Trp Thr 
1               5                   


<210>  71
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2G3 VH

<400>  71

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Pro Asn Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asn Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  72
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2G3 VH nucleotide

<400>  72
gaggtgaagc tgcaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctttgcca tgtcttggat tcgccagact      120

ccggaaaaga ggctggagtg ggtcgcggcc attagtgatg gtggtactta cacctactat      180

ccaaacaatg taaagggccg attcaccatc tccagagacg atgccaagaa taacctgtac      240

ctgcaaatga gtcatctgaa gtctgaggac acagccatgt attactgtgt aagaaatagg      300

gggggaccct ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  73
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2G3VL

<400>  73

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  74
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2G3VL nucleotide

<400>  74
gatatcgtgc tcactcagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg aatagtaacc cacccacgtt cggtgctggg      300

accaagctgg agctgaaa                                                    318


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2G3 HCDR1

<400>  75

Ser Phe Ala Met Ser 
1               5   


<210>  76
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2G3 HCDR2

<400>  76

Ala Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Pro Asn Asn Val Lys 
1               5                   10                  15      


Gly 
    


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2G3 HCDR3

<400>  77

Asn Arg Gly Gly Pro Phe Asp Tyr 
1               5               


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2G3 LCDR1

<400>  78

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2G3 LCDR2

<400>  79

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2G3 LCDR3

<400>  80

Gln Gln Trp Asn Ser Asn Pro Pro Thr 
1               5                   


<210>  81
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11 VH

<400>  81

Glu Val Gln Leu Gln Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  82
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2F11 VH nucleotide

<400>  82
gaggtgcagc tgcaggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccagact      120

ccggaaaaga ggctggagtg ggtcgcaatc attggtgatg gtgatactta cacctactat      180

ccagacagtg taaagggccg attcaccgtc tccagagaca atgccaagaa caacctctac      240

ctgcaaatga gccatctgaa gtctgaggac acagccatgt attactgtgt aagaactagg      300

gggggaccct ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  83
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11VL

<400>  83

Asp Ile Val Leu Thr Gln Thr Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Gly Ser Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ile Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys 
            100                 105     


<210>  84
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2F11VL nucleotide

<400>  84
gatatcgtgc tcacccaaac tccagcactc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaggt tccatgcact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccaacagtgg agtagtatcc cacccacgtt cggtgctggg      300

accacgctgg agctgaaa                                                    318


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11 HCDR1

<400>  85

Ser Tyr Ala Met Ser 
1               5   


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11 HCDR2

<400>  86

Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11 HCDR3

<400>  87

Thr Arg Gly Gly Pro Phe Asp Tyr 
1               5               


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11 LCDR1

<400>  88

Ser Ala Ser Ser Ser Val Gly Ser Met His 
1               5                   10  


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11 LCDR2

<400>  89

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  90
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11 LCDR3

<400>  90

Gln Gln Trp Ser Ser Ile Pro Pro Thr 
1               5                   


<210>  91
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16647VL

<400>  91

Glu Ile Leu Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Ser Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ile Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys 
            100                 105     


<210>  92
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16647VL nucleotide

<400>  92
gagatcctgc tgacccagag ccctgccttt atgagcgcca cccccggcga gaaggtgacc       60

atcacctgca gcgccagcag cagcgtgggc agcatgcact ggtatcaaca gaagagcggc      120

cagagcccca ggaggctgat ctacgacacc agcaagctgg ccagcggcgt gcctgacagg      180

ttctctggta gcggcagcgg caccgactac accctgacca tcagcagcct ggaggccgaa      240

gacgccgcca cctactactg ccagcagtgg agcagcatcc ctcccacctt cggcgctgga      300

accaccctgg agctgaag                                                    318


<210>  93
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9419VH

<400>  93

Glu Val His Leu Gln Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  94
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9419VH nucleotide

<400>  94
gaggtgcacc tgcaggagtc tggtggagcc ctggtgaagc ccggaggaag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt gagacaggcc      120

cctgagaagg gcctggagtg ggtggccatc atcggcgacg gcgacaccta cacctactac      180

cccgacagcg tgaagggcag gttcaccatc agcagggaca acgctaagaa caccctgtac      240

ctgcagatga gcaacctgaa gagcgaggac accgccatgt actactgcgt gaggaccaga      300

ggcggccctt tcgactactg gggccagggc accaccctga cagtgagcag c               351


<210>  95
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  d9419VH

<400>  95

Glu Val His Leu Gln Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Lys Pro Glu Lys Asn Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asp Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  96
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   d9419VH nucleotide

<400>  96
gaggtgcatc tgcaggagag cggcggagcc ctggtgaaac ctggcggaag cctgagactg       60

agctgcgccg cctccggctt caccttcagc tcctacgcca tgagctgggt gaggcagaag      120

cccgagaaga acctggagtg ggtggccatc atcggcgacg gcgacaccta cacctactac      180

cccgacagcg tgaagggcag gttcaccatc agcagggaca acgccaagaa caccctgtac      240

ctgcagatga gcgacctgaa gagcgaggac accgccatgt actactgcgt gaggaccagg      300

ggcggccctt tcgactattg gggccagggc acaaccctga ccgtgagcag c               351


<210>  97
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9424VH

<400>  97

Glu Val His Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  98
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9424VH nucleotide

<400>  98
gaggtgcacc tgcaggagtc tggtggaggc ctggtgaagc ccggaggaag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt gagacagacc      120

cctgagaagg gcctggagtg ggtggccatc atcggcgacg gcgacaccta cacctactac      180

cccgacagcg tgaagggcag gttcaccatc agcagggaca acgctaagaa caccctgtac      240

ctgcagatga acagcctgaa gagcgaggac accgccatgt actactgcgt gaggaccaga      300

ggcggccctt tcgactactg gggccagggc accaccctga cagtgagcag c               351


<210>  99
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  d9424VH

<400>  99

Glu Val His Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Asn Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asp Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  100
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  d9424 nucleotide

<400>  100
gaggtgcatc tgcaggagag cggcggaggc ctggtgaaac ctggcggaag cctgagactg       60

agctgcgccg cctccggctt caccttcagc tcctacgcca tgagctgggt gaggcagacg      120

cccgagaaga acctggagtg ggtggccatc atcggcgacg gcgacaccta cacctactac      180

cccgacagcg tgaagggcag gttcaccatc agcagggaca acgccaagaa caccctgtac      240

ctgcagatga acgacctgaa gagcgaggac accgccatgt actactgcgt gaggaccagg      300

ggcggccctt tcgactattg gggccagggc acaaccctga ccgtgagcag c               351


<210>  101
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12674VH

<400>  101

Glu Val His Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  102
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12674VH nucleotide

<400>  102
gaggtgcacc tgcaagagag cggaggaggc ctggtgaaac ctggcggcag cctgaggctg       60

agctgtgctg ccagcggctt caccttctcc agctacgcca tgagctgggt gaggcaggcg      120

cccggcaaag gcctggagtg ggtggccatc atcggcgacg gcgacaccta cacctactac      180

cccgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caggctgtac      240

ctgcagatga acagcctgaa gagcgaggac accgccatgt actactgcgt gaggaccaga      300

ggcggccctt tcgactactg gggccaggga accaccctga ccgtgagcag c               351


<210>  103
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  d12674VH

<400>  103

Glu Val His Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asp Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  104
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  d12674 nucleotide

<400>  104
gaggtgcacc tgcaagagag cggaggcgga ctggtgaaac ctggcggcag cctgagactg       60

agctgtgccg ccagcggctt caccttcagc agctacgcca tgagctgggt gaggcaggcc      120

cccggtaagg gcctggagtg ggtggccatc atcggcgacg gcgacaccta cacctactac      180

cccgacagcg tgaagggcag attcaccatc agcagggaca actccaagaa caggctgtac      240

ctgcagatga acgacctgaa gagcgaggac accgccatgt actactgcgt gaggaccagg      300

ggcggccctt tcgattactg gggccagggc acaaccctga ccgtgagcag c               351


<210>  105
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12996VH

<400>  105

Glu Val His Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  106
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12996VH nucleotide

<400>  106
gaggtgcacc tgcaagagag cggaggaggc ctggtgaaac ctggcggcag cctgaggctg       60

agctgtgctg ccagcggctt caccttctcc agctacgcca tgagctgggt gaggcaggcg      120

cccgagaaag gcctggagtg ggtggccatc atcggcgacg gcgacaccta cacctactac      180

cccgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caggctgtac      240

ctgcagatga acagcctgaa gagcgaggac accgccatgt actactgcgt gaggaccaga      300

ggcggccctt tcgactactg gggccaggga accaccctga ccgtgagcag c               351


<210>  107
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  d12996VH

<400>  107

Glu Val His Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Glu Pro Glu Lys Asn Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asp Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  108
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  d12996VH nucleotide

<400>  108
gaggtgcacc tgcaagagag cggaggcgga ctggtgaaac ctggcggcag cctgagactg       60

agctgtgccg ccagcggctt caccttcagc agctacgcca tgagctgggt gaggcaggaa      120

cccgagaaga acctggagtg ggtggccatc atcggcgacg gcgacaccta cacctactac      180

cccgacagcg tgaagggcag attcaccatc agcagggaca actccaagaa caggctgtac      240

ctgcagatga acgacctgaa gagcgaggac accgccatgt actactgcgt gaggaccagg      300

ggcggccctt tcgattactg gggccagggc acaaccctga ccgtgagcag c               351


<210>  109
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14822VH

<400>  109

Glu Val His Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  110
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14822VH nucleotide

<400>  110
gaggtgcacc tgcaagagag cggaggaggc ctggtgaaac ctggcggcag cctgaggctg       60

agctgtgctg ccagcggctt caccttctcc agctacgcca tgagctgggt gaggcagatg      120

cccggcaaag gcctggagtg ggtggccatc atcggcgacg gcgacaccta cacctactac      180

cccgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa cacgctgtac      240

ctgcagatga acagcctgaa gagcgaggac accgccatgt actactgcgt gaggaccaga      300

ggcggccctt tcgactactg gggccaggga accaccctga ccgtgagcag c               351


<210>  111
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  d14882VH

<400>  111

Glu Val His Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asp Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  112
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  d14882VH nucleotide

<400>  112
gaggtgcacc tgcaagagag cggaggcgga ctggtgaaac ctggcggcag cctgagactg       60

agctgtgccg ccagcggctt caccttcagc agctacgcca tgagctgggt gaggcagacc      120

cccgataagg gcctggagtg ggtggccatc atcggcgacg gcgacaccta cacctactac      180

cccgacagcg tgaagggcag attcaccatc agcagggaca actccaagaa cacgctgtac      240

ctgcagatga acgacctgaa gagcgaggac accgccatgt actactgcgt gaggaccagg      300

ggcggccctt tcgattactg gggccagggc acaaccctga ccgtgagcag c               351


<210>  113
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16647VH

<400>  113

Gln Val Glu Leu Arg Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  114
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16647VH nucleotide

<400>  114
caggtggagc tgagagagag cggaggaggc ctggtgaaac ctggcggcag cctgaggctg       60

agctgtgctg ccagcggctt caccttctcc agctacgcca tgagctgggt gaggcagatg      120

cccggcaaag gcctggagtg ggtggccatc atcggcgacg gcgacaccta cacctactac      180

cccgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caggctgtac      240

ctgcagatga acagcctgaa gagcgaggac accgccatgt actactgcgt gaggaccaga      300

ggcggccctt tcgactactg gggccaggga accaccctga ccgtgagcag c               351


<210>  115
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  d16647VH

<400>  115

Gln Val Glu Leu Arg Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asp Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  116
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  d16647VH nucleotide

<400>  116
caggtggagc tgagggagag cggaggcgga ctggtgaaac ctggcggcag cctgagactg       60

agctgtgccg ccagcggctt caccttcagc agctacgcca tgagctgggt gaggcagacc      120

cccgataagg gcctggagtg ggtggccatc atcggcgacg gcgacaccta cacctactac      180

cccgacagcg tgaagggcag attcaccatc agcagggaca actccaagaa caggctgtac      240

ctgcagatga acgacctgaa gagcgaggac accgccatgt actactgcgt gaggaccagg      300

ggcggccctt tcgattactg gggccagggc acaaccctga ccgtgagcag c               351


<210>  117
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m2E7light chain

<400>  117

Asp Ile Val Met Thr Gln Ser Thr Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Arg Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Arg Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asn Thr Pro Pro Phe 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  118
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m2E7 heavy chain

<400>  118

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Ser Gly Val Pro Thr Tyr Val Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Ser Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Thr Arg Glu Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  119
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m2B8 light chain

<400>  119

Asp Ile Val Met Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Arg Glu Lys Pro Gly Lys Thr Asn Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  120
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m2B8 heavy chain

<400>  120

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asn Thr Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Tyr Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Arg Thr Asp Asp Thr Ala Ile Tyr 
                85                  90                  95      


Phe Cys Val Arg Glu Leu Gly Leu Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  121
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m4H3 light chain

<400>  121

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Met His Trp Tyr Gln Gln Arg Lys Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Thr Asn Asn Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Phe Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  122
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m4H3 heavy chain

<400>  122

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Asn Ile Asn Trp Val Lys Gln Thr Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Pro Asn Tyr Gly Thr Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asn Gly Asp Tyr Val Gly Tyr Ala Met Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  123
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m3E7 light chain

<400>  123

Asp Ile Val Met Thr Gln Thr Thr Ala Ile Met Ser Ala Phe Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Phe 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  124
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m3E7 heavy chain

<400>  124

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu His Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr His Ser Gly Ala Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Ile Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  125
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m1A8 light chain

<400>  125

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  126
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m1A8 heavy chain

<400>  126

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Ser 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asp Ser Gly Phe Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Arg Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ser Tyr Tyr Asp Thr Ser Tyr Thr Ser Met Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Asn Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  127
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m4G1 light chain

<400>  127

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  128
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m4G1 heavy chain

<400>  128

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Lys Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Asn Tyr Ala Thr Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Tyr Ser Tyr Tyr Ser Tyr Gly Gly Gly Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  129
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m2G3 light chain

<400>  129

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  130
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m2G3 heavy chain

<400>  130

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Pro Asn Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asn Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  131
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m2F11 light chain

<400>  131

Asp Ile Val Leu Thr Gln Thr Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Gly Ser Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ile Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  132
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m2F11 heavy chain

<400>  132

Glu Val Gln Leu Gln Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Gly Asp Gly Asp Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Arg Gly Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  133
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m3B8 light chain

<400>  133

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Phe Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  134
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m3B8 heavy chain

<400>  134

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Thr Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ile Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Glu Gly Asp Tyr Gly Asp Tyr Val Gly Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  135
<211>  652
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m2E7light chain(nucleotide)

<400>  135
gatattgtga tgacacaatc tacagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc      120

acctccccca gaagatggat ttatgacaca tccagactgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtaataccc cacccttcac gttcggtgct      300

gggaccaagt tggagctgaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggtaccgct agcgttgtgt gcctgctgaa taacttttat      420

ccacgggagg ctaaggtgca gtggaaagtg gacaatgccc tccagagcgg aaatagccaa      480

gagtccgtta ccgaacagga ctctaaagac tctacatact ccctgtcctc cacactgacc      540

ctctccaagg ccgactatga gaaacacaag gtttacgcat gcgaggtcac acaccaggga      600

ctctcctctc ccgtgaccaa gagcttcaac cggggagaat gctaatgaat tc              652


<210>  136
<211>  1348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m2E7 heavy chain(nucleotide)

<400>  136
gaggtgcagc tgcaggagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca acctatggaa tgagctgggt gaaacaggct      120

ccaggaaagg gtttacagtg gatgggctgg ataaacacca actctggagt gccaacctat      180

gttgaggact tcaagggacg gtttgccttc tctttggaat cctctgccaa cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctatat acttctgtac aagagagggg      300

gatgctctgg actactgggg tcaaggaacc tcagtcaccg tctcctcagc cagcactaag      360

gggccctctg tgtttccact cgccccttct agcaaaagca cttccggagg cactgcagca      420

ctcgggtgtc tggtcaaaga ttatttccct gagccagtca ccgtgagctg gaactctggc      480

gccctcacct ccggggttca cacctttcca gccgtcctgc agtcctccgg cctgtactcc      540

ctgagcagcg tcgttaccgt gccatcctct tctctgggga cccagacata catctgcaat      600

gtcaaccata agcctagcaa caccaaggtg gacaaaaagg tcgagccaaa gagctgcgat      660

aagacacaca cctgccctcc atgccccgca cctgaactcc tgggcgggcc ttccgttttc      720

ctgtttcctc ccaagcccaa ggatacactg atgattagcc gcacccccga agtcacttgc      780

gtggtggtgg atgtgagcca tgaagatcca gaagttaagt ttaactggta tgtggacggg      840

gtcgaggtgc acaatgctaa aacaaagccc agggaggagc aatataactc cacatacaga      900

gtggtgtccg ttctgacagt cctgcaccag gactggctga acgggaagga atacaagtgc      960

aaggtgtcta ataaggcact gccagccccc atagagaaga caatctctaa agctaaaggc     1020

caaccacgcg agcctcaggt ctacacactg ccaccatcca gggacgaact gaccaagaat     1080

caggtgagcc tgacttgtct cgtcaaagga ttctacccaa gcgacatcgc cgtggagtgg     1140

gaatccaacg gccaaccaga gaacaactac aagaccaccc caccagtcct ggactctgat     1200

gggagctttt tcctgtattc caagctgaca gtggacaagt ctcggtggca acagggcaac     1260

gtgttcagct gctccgtgat gcatgaagcc ctgcataacc actataccca gaaaagcctc     1320

agcctgtccc ccgggaaata atgaattc                                        1348


<210>  137
<211>  652
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m2B8 light chain(nucleotide)

<400>  137
gacattgtga tgacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact       60

ataaattgca gggcaagtaa gagcattagc aaatatttag cctggtatcg agagaaacct      120

gggaaaacta ataatcttct tatctactct ggatccactt tgcaatctgg aattccatca      180

aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtag cctggagcct      240

gaagattttg caatgtatta ctgtcaacag cataatgaat acccgctcac gttcggtgct      300

gggaccaagc tggagctgaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggtaccgct agcgttgtgt gcctgctgaa taacttttat      420

ccacgggagg ctaaggtgca gtggaaagtg gacaatgccc tccagagcgg aaatagccaa      480

gagtccgtta ccgaacagga ctctaaagac tctacatact ccctgtcctc cacactgacc      540

ctctccaagg ccgactatga gaaacacaag gtttacgcat gcgaggtcac acaccaggga      600

ctctcctctc ccgtgaccaa gagcttcaac cggggagaat gctaatgaat tc              652


<210>  138
<211>  1360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m2B8 heavy chain(nucleotide)

<400>  138
gaggtgcagc tgcaggagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc       60

tcatgtgcag cctctggatt caacttcaat acctacacca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagatata aaagtaataa ttatgcaaca      180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc agaaagcatc      240

ctctatctgc aaatgaacaa cttgagaact gacgacacag ccatttattt ctgtgtgagg      300

gaactgggac tgtggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360

gccagcacta aggggccctc tgtgtttcca ctcgcccctt ctagcaaaag cacttccgga      420

ggcactgcag cactcgggtg tctggtcaaa gattatttcc ctgagccagt caccgtgagc      480

tggaactctg gcgccctcac ctccggggtt cacacctttc cagccgtcct gcagtcctcc      540

ggcctgtact ccctgagcag cgtcgttacc gtgccatcct cttctctggg gacccagaca      600

tacatctgca atgtcaacca taagcctagc aacaccaagg tggacaaaaa ggtcgagcca      660

aagagctgcg ataagacaca cacctgccct ccatgccccg cacctgaact cctgggcggg      720

ccttccgttt tcctgtttcc tcccaagccc aaggatacac tgatgattag ccgcaccccc      780

gaagtcactt gcgtggtggt ggatgtgagc catgaagatc cagaagttaa gtttaactgg      840

tatgtggacg gggtcgaggt gcacaatgct aaaacaaagc ccagggagga gcaatataac      900

tccacataca gagtggtgtc cgttctgaca gtcctgcacc aggactggct gaacgggaag      960

gaatacaagt gcaaggtgtc taataaggca ctgccagccc ccatagagaa gacaatctct     1020

aaagctaaag gccaaccacg cgagcctcag gtctacacac tgccaccatc cagggacgaa     1080

ctgaccaaga atcaggtgag cctgacttgt ctcgtcaaag gattctaccc aagcgacatc     1140

gccgtggagt gggaatccaa cggccaacca gagaacaact acaagaccac cccaccagtc     1200

ctggactctg atgggagctt tttcctgtat tccaagctga cagtggacaa gtctcggtgg     1260

caacagggca acgtgttcag ctgctccgtg atgcatgaag ccctgcataa ccactatacc     1320

cagaaaagcc tcagcctgtc ccccgggaaa taatgaattc                           1360


<210>  139
<211>  652
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m4H3 light chain(nucleotide)

<400>  139
gatatcgttc tcacccagtc tccagccatc ctctctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gagcattggc acaagcatgc actggtatca gcaaagaaaa      120

aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct      240

gaggatattg cagattatta ctgtcaacaa actaataact ggccgtggac gttcggtgga      300

ggcaccaagc tggaattcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggtaccgct agcgttgtgt gcctgctgaa taacttttat      420

ccacgggagg ctaaggtgca gtggaaagtg gacaatgccc tccagagcgg aaatagccaa      480

gagtccgtta ccgaacagga ctctaaagac tctacatact ccctgtcctc cacactgacc      540

ctctccaagg ccgactatga gaaacacaag gtttacgcat gcgaggtcac acaccaggga      600

ctctcctctc ccgtgaccaa gagcttcaac cggggagaat gctaatgaat tc              652


<210>  140
<211>  1363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m4H3 heavy chain(nucleotide)

<400>  140
caggtgcagc tgcagcagtc tggacctgag ctggtgaagc ctggcgcttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact gcctacaaca ttaactgggt gaagcagacc      120

aatggaaaga gccttgagtg gattggaata attaatccta actatggtac tactagttac      180

aaccagaagt tcaagggcaa ggccacattg actgtagacc aatcttccag tacagcctac      240

atgcagctca acagcctgac atctgaggac tctgcagtct attactgtgc aagacggaat      300

ggtgactacg tgggatatgc tatggactcc tggggtcaag gaacctcagt caccgtctcc      360

tcagccagca ctaaggggcc ctctgtgttt ccactcgccc cttctagcaa aagcacttcc      420

ggaggcactg cagcactcgg gtgtctggtc aaagattatt tccctgagcc agtcaccgtg      480

agctggaact ctggcgccct cacctccggg gttcacacct ttccagccgt cctgcagtcc      540

tccggcctgt actccctgag cagcgtcgtt accgtgccat cctcttctct ggggacccag      600

acatacatct gcaatgtcaa ccataagcct agcaacacca aggtggacaa aaaggtcgag      660

ccaaagagct gcgataagac acacacctgc cctccatgcc ccgcacctga actcctgggc      720

gggccttccg ttttcctgtt tcctcccaag cccaaggata cactgatgat tagccgcacc      780

cccgaagtca cttgcgtggt ggtggatgtg agccatgaag atccagaagt taagtttaac      840

tggtatgtgg acggggtcga ggtgcacaat gctaaaacaa agcccaggga ggagcaatat      900

aactccacat acagagtggt gtccgttctg acagtcctgc accaggactg gctgaacggg      960

aaggaataca agtgcaaggt gtctaataag gcactgccag cccccataga gaagacaatc     1020

tctaaagcta aaggccaacc acgcgagcct caggtctaca cactgccacc atccagggac     1080

gaactgacca agaatcaggt gagcctgact tgtctcgtca aaggattcta cccaagcgac     1140

atcgccgtgg agtgggaatc caacggccaa ccagagaaca actacaagac caccccacca     1200

gtcctggact ctgatgggag ctttttcctg tattccaagc tgacagtgga caagtctcgg     1260

tggcaacagg gcaacgtgtt cagctgctcc gtgatgcatg aagccctgca taaccactat     1320

acccagaaaa gcctcagcct gtcccccggg aaataatgaa ttc                       1363


<210>  141
<211>  652
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m3E7 light chain(nucleotide)

<400>  141
gacattgtga tgacccaaac tacagcaatc atgtctgcat ttccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcaacat ggaggctgaa      240

gatgctgcca cttattattg ccagcagtgg agtcgtaacc cacccttcac gttcggtgct      300

gggaccaagc tggagctgaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggtaccgct agcgttgtgt gcctgctgaa taacttttat      420

ccacgggagg ctaaggtgca gtggaaagtg gacaatgccc tccagagcgg aaatagccaa      480

gagtccgtta ccgaacagga ctctaaagac tctacatact ccctgtcctc cacactgacc      540

ctctccaagg ccgactatga gaaacacaag gtttacgcat gcgaggtcac acaccaggga      600

ctctcctctc ccgtgaccaa gagcttcaac cggggagaat gctaatgaat tc              652


<210>  142
<211>  1348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m3E7 heavy chain(nucleotide)

<400>  142
cagatccagc tggtgcagag cggaccagaa ctgaagaagc caggagagac agtcaagatc       60

tcctgcaagg cttctggata tacgttcaca acctatggaa tgagctgggt gaaacaggct      120

ccaggaaagg gtttgcactg gatgggctgg ataaacaccc actctggagc gccaacatat      180

gttgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgccttt      240

ttgcagatca acaacctcat aaatgaggac acggctacat atttctgtgc aagagagggg      300

gatgctctgg actactgggg tcaaggaacc tcagtcaccg tctcctcagc cagcactaag      360

gggccctctg tgtttccact cgccccttct agcaaaagca cttccggagg cactgcagca      420

ctcgggtgtc tggtcaaaga ttatttccct gagccagtca ccgtgagctg gaactctggc      480

gccctcacct ccggggttca cacctttcca gccgtcctgc agtcctccgg cctgtactcc      540

ctgagcagcg tcgttaccgt gccatcctct tctctgggga cccagacata catctgcaat      600

gtcaaccata agcctagcaa caccaaggtg gacaaaaagg tcgagccaaa gagctgcgat      660

aagacacaca cctgccctcc atgccccgca cctgaactcc tgggcgggcc ttccgttttc      720

ctgtttcctc ccaagcccaa ggatacactg atgattagcc gcacccccga agtcacttgc      780

gtggtggtgg atgtgagcca tgaagatcca gaagttaagt ttaactggta tgtggacggg      840

gtcgaggtgc acaatgctaa aacaaagccc agggaggagc aatataactc cacatacaga      900

gtggtgtccg ttctgacagt cctgcaccag gactggctga acgggaagga atacaagtgc      960

aaggtgtcta ataaggcact gccagccccc atagagaaga caatctctaa agctaaaggc     1020

caaccacgcg agcctcaggt ctacacactg ccaccatcca gggacgaact gaccaagaat     1080

caggtgagcc tgacttgtct cgtcaaagga ttctacccaa gcgacatcgc cgtggagtgg     1140

gaatccaacg gccaaccaga gaacaactac aagaccaccc caccagtcct ggactctgat     1200

gggagctttt tcctgtattc caagctgaca gtggacaagt ctcggtggca acagggcaac     1260

gtgttcagct gctccgtgat gcatgaagcc ctgcataacc actataccca gaaaagcctc     1320

agcctgtccc ccgggaaata atgaattc                                        1348


<210>  143
<211>  652
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m1A8 light chain(nucleotide)

<400>  143
gatattgtgc tgacccagtc tccagccatc ctgtctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gagcattggc acaagcatac attggtatca gcaaagaaca      120

aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct      240

gaagatattg cagattatta ctgtcaacaa agtaatagct ggccactcac gttcggtgct      300

gggaccaagc tggagctgaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggtaccgct agcgttgtgt gcctgctgaa taacttttat      420

ccacgggagg ctaaggtgca gtggaaagtg gacaatgccc tccagagcgg aaatagccaa      480

gagtccgtta ccgaacagga ctctaaagac tctacatact ccctgtcctc cacactgacc      540

ctctccaagg ccgactatga gaaacacaag gtttacgcat gcgaggtcac acaccaggga      600

ctctcctctc ccgtgaccaa gagcttcaac cggggagaat gctaatgaat tc              652


<210>  144
<211>  1366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m1A8 heavy chain(nucleotide)

<400>  144
gaggtgcagc tgcaggagtc tggggctgaa ttggtaaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta cagtttcacc agctcctgga tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggaatg attcatcctg atagtggttt tactaactac      180

aatgagaagt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcgcctca gcagcctgac atctgaggac tctgcggtct attactgtgc aaggacctct      300

tactacgata ctagctacac ttctatggac ttctggggtc aaggaaactc agtcaccgtc      360

tcctcagcca gcactaaggg gccctctgtg tttccactcg ccccttctag caaaagcact      420

tccggaggca ctgcagcact cgggtgtctg gtcaaagatt atttccctga gccagtcacc      480

gtgagctgga actctggcgc cctcacctcc ggggttcaca cctttccagc cgtcctgcag      540

tcctccggcc tgtactccct gagcagcgtc gttaccgtgc catcctcttc tctggggacc      600

cagacataca tctgcaatgt caaccataag cctagcaaca ccaaggtgga caaaaaggtc      660

gagccaaaga gctgcgataa gacacacacc tgccctccat gccccgcacc tgaactcctg      720

ggcgggcctt ccgttttcct gtttcctccc aagcccaagg atacactgat gattagccgc      780

acccccgaag tcacttgcgt ggtggtggat gtgagccatg aagatccaga agttaagttt      840

aactggtatg tggacggggt cgaggtgcac aatgctaaaa caaagcccag ggaggagcaa      900

tataactcca catacagagt ggtgtccgtt ctgacagtcc tgcaccagga ctggctgaac      960

gggaaggaat acaagtgcaa ggtgtctaat aaggcactgc cagcccccat agagaagaca     1020

atctctaaag ctaaaggcca accacgcgag cctcaggtct acacactgcc accatccagg     1080

gacgaactga ccaagaatca ggtgagcctg acttgtctcg tcaaaggatt ctacccaagc     1140

gacatcgccg tggagtggga atccaacggc caaccagaga acaactacaa gaccacccca     1200

ccagtcctgg actctgatgg gagctttttc ctgtattcca agctgacagt ggacaagtct     1260

cggtggcaac agggcaacgt gttcagctgc tccgtgatgc atgaagccct gcataaccac     1320

tatacccaga aaagcctcag cctgtccccc gggaaataat gaattc                    1366


<210>  145
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m4G1 light chain(nucleotide)

<400>  145
gatatcttgc tgacccaatc tccagccatc ctgtctgtga gtccaggaga aagagtcagt       60

ttttcctgca gggccagtca gagcattggc acaagcatac actggtatca gcaaagaaca      120

aatgggtctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttattctta gcatcaacag tgtggagtct      240

gaggatattg ctgattatta ctgtcagcaa agtaatagct ggccgtggac gttcggtgga      300

ggcaccaggc tggaaatcaa a                                                321


<210>  146
<211>  1369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m4G1 heavy chain(nucleotide)

<400>  146
caggtccagc tgcagcagtc cggacctgag ctggtgaagc ctggcgcttc agtgaagata       60

tcatgcaagg cttctggtta ctcattcact gcctacaaca tgaactgggt gaagcagagc      120

aagggaaaga gccttgagtg gattggacta attaatccta actatgccac gactagttac      180

aatcagaagt tcaaggacaa ggccacattg actgtggacc aatcttccag cacagcctac      240

atgcagctca acagcctgac atctgaggac tctgcagtct attactgtgc ctactatagt      300

tactatagtt acgggggggg atatgctatg gactactggg gtcaaggaac ctcagtcacc      360

gtctcctcag ccagcactaa ggggccctct gtgtttccac tcgccccttc tagcaaaagc      420

acttccggag gcactgcagc actcgggtgt ctggtcaaag attatttccc tgagccagtc      480

accgtgagct ggaactctgg cgccctcacc tccggggttc acacctttcc agccgtcctg      540

cagtcctccg gcctgtactc cctgagcagc gtcgttaccg tgccatcctc ttctctgggg      600

acccagacat acatctgcaa tgtcaaccat aagcctagca acaccaaggt ggacaaaaag      660

gtcgagccaa agagctgcga taagacacac acctgccctc catgccccgc acctgaactc      720

ctgggcgggc cttccgtttt cctgtttcct cccaagccca aggatacact gatgattagc      780

cgcacccccg aagtcacttg cgtggtggtg gatgtgagcc atgaagatcc agaagttaag      840

tttaactggt atgtggacgg ggtcgaggtg cacaatgcta aaacaaagcc cagggaggag      900

caatataact ccacatacag agtggtgtcc gttctgacag tcctgcacca ggactggctg      960

aacgggaagg aatacaagtg caaggtgtct aataaggcac tgccagcccc catagagaag     1020

acaatctcta aagctaaagg ccaaccacgc gagcctcagg tctacacact gccaccatcc     1080

agggacgaac tgaccaagaa tcaggtgagc ctgacttgtc tcgtcaaagg attctaccca     1140

agcgacatcg ccgtggagtg ggaatccaac ggccaaccag agaacaacta caagaccacc     1200

ccaccagtcc tggactctga tgggagcttt ttcctgtatt ccaagctgac agtggacaag     1260

tctcggtggc aacagggcaa cgtgttcagc tgctccgtga tgcatgaagc cctgcataac     1320

cactataccc agaaaagcct cagcctgtcc cccgggaaat aatgaattc                 1369


<210>  147
<211>  649
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m2G3 light chain(nucleotide)

<400>  147
gatatcgtgc tcactcagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg aatagtaacc cacccacgtt cggtgctggg      300

accaagctgg agctgaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg taccgctagc gttgtgtgcc tgctgaataa cttttatcca      420

cgggaggcta aggtgcagtg gaaagtggac aatgccctcc agagcggaaa tagccaagag      480

tccgttaccg aacaggactc taaagactct acatactccc tgtcctccac actgaccctc      540

tccaaggccg actatgagaa acacaaggtt tacgcatgcg aggtcacaca ccagggactc      600

tcctctcccg tgaccaagag cttcaaccgg ggagaatgct aatgaattc                  649


<210>  148
<211>  1351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m2G3 heavy chain(nucleotide)

<400>  148
gaggtgaagc tgcaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctttgcca tgtcttggat tcgccagact      120

ccggaaaaga ggctggagtg ggtcgcggcc attagtgatg gtggtactta cacctactat      180

ccaaacaatg taaagggccg attcaccatc tccagagacg atgccaagaa taacctgtac      240

ctgcaaatga gtcatctgaa gtctgaggac acagccatgt attactgtgt aagaaatagg      300

gggggaccct ttgactactg gggccaaggc accactctca cagtctcctc agccagcact      360

aaggggccct ctgtgtttcc actcgcccct tctagcaaaa gcacttccgg aggcactgca      420

gcactcgggt gtctggtcaa agattatttc cctgagccag tcaccgtgag ctggaactct      480

ggcgccctca cctccggggt tcacaccttt ccagccgtcc tgcagtcctc cggcctgtac      540

tccctgagca gcgtcgttac cgtgccatcc tcttctctgg ggacccagac atacatctgc      600

aatgtcaacc ataagcctag caacaccaag gtggacaaaa aggtcgagcc aaagagctgc      660

gataagacac acacctgccc tccatgcccc gcacctgaac tcctgggcgg gccttccgtt      720

ttcctgtttc ctcccaagcc caaggataca ctgatgatta gccgcacccc cgaagtcact      780

tgcgtggtgg tggatgtgag ccatgaagat ccagaagtta agtttaactg gtatgtggac      840

ggggtcgagg tgcacaatgc taaaacaaag cccagggagg agcaatataa ctccacatac      900

agagtggtgt ccgttctgac agtcctgcac caggactggc tgaacgggaa ggaatacaag      960

tgcaaggtgt ctaataaggc actgccagcc cccatagaga agacaatctc taaagctaaa     1020

ggccaaccac gcgagcctca ggtctacaca ctgccaccat ccagggacga actgaccaag     1080

aatcaggtga gcctgacttg tctcgtcaaa ggattctacc caagcgacat cgccgtggag     1140

tgggaatcca acggccaacc agagaacaac tacaagacca ccccaccagt cctggactct     1200

gatgggagct ttttcctgta ttccaagctg acagtggaca agtctcggtg gcaacagggc     1260

aacgtgttca gctgctccgt gatgcatgaa gccctgcata accactatac ccagaaaagc     1320

ctcagcctgt cccccgggaa ataatgaatt c                                    1351


<210>  149
<211>  649
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m2F11 light chain(nucleotide)

<400>  149
gatatcgtgc tcacccaaac tccagcactc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaggt tccatgcact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccaacagtgg agtagtatcc cacccacgtt cggtgctggg      300

accacgctgg agctgaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg taccgctagc gttgtgtgcc tgctgaataa cttttatcca      420

cgggaggcta aggtgcagtg gaaagtggac aatgccctcc agagcggaaa tagccaagag      480

tccgttaccg aacaggactc taaagactct acatactccc tgtcctccac actgaccctc      540

tccaaggccg actatgagaa acacaaggtt tacgcatgcg aggtcacaca ccagggactc      600

tcctctcccg tgaccaagag cttcaaccgg ggagaatgct aatgaattc                  649


<210>  150
<211>  1351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m2F11 heavy chain(nucleotide)

<400>  150
gaggtgcagc tgcaggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccagact      120

ccggaaaaga ggctggagtg ggtcgcaatc attggtgatg gtgatactta cacctactat      180

ccagacagtg taaagggccg attcaccgtc tccagagaca atgccaagaa caacctctac      240

ctgcaaatga gccatctgaa gtctgaggac acagccatgt attactgtgt aagaactagg      300

gggggaccct ttgactactg gggccaaggc accactctca cagtctcctc agccagcact      360

aaggggccct ctgtgtttcc actcgcccct tctagcaaaa gcacttccgg aggcactgca      420

gcactcgggt gtctggtcaa agattatttc cctgagccag tcaccgtgag ctggaactct      480

ggcgccctca cctccggggt tcacaccttt ccagccgtcc tgcagtcctc cggcctgtac      540

tccctgagca gcgtcgttac cgtgccatcc tcttctctgg ggacccagac atacatctgc      600

aatgtcaacc ataagcctag caacaccaag gtggacaaaa aggtcgagcc aaagagctgc      660

gataagacac acacctgccc tccatgcccc gcacctgaac tcctgggcgg gccttccgtt      720

ttcctgtttc ctcccaagcc caaggataca ctgatgatta gccgcacccc cgaagtcact      780

tgcgtggtgg tggatgtgag ccatgaagat ccagaagtta agtttaactg gtatgtggac      840

ggggtcgagg tgcacaatgc taaaacaaag cccagggagg agcaatataa ctccacatac      900

agagtggtgt ccgttctgac agtcctgcac caggactggc tgaacgggaa ggaatacaag      960

tgcaaggtgt ctaataaggc actgccagcc cccatagaga agacaatctc taaagctaaa     1020

ggccaaccac gcgagcctca ggtctacaca ctgccaccat ccagggacga actgaccaag     1080

aatcaggtga gcctgacttg tctcgtcaaa ggattctacc caagcgacat cgccgtggag     1140

tgggaatcca acggccaacc agagaacaac tacaagacca ccccaccagt cctggactct     1200

gatgggagct ttttcctgta ttccaagctg acagtggaca agtctcggtg gcaacagggc     1260

aacgtgttca gctgctccgt gatgcatgaa gccctgcata accactatac ccagaaaagc     1320

ctcagcctgt cccccgggaa ataatgaatt c                                    1351


<210>  151
<211>  664
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m3B8 light chain(nucleotide)

<400>  151
gatatcgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagagccacc       60

atctcctgca gagccagtga aagtgttgaa tattatggca caagtttaat gcagtggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa cgtagaatct      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctgtggagg aggatgattt tgcaatgtat ttctgtcagc aaagtaggaa gattccttac      300

acgttcggag gggggaccaa gctggaaata aaacgtacgg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggtaccg ctagcgttgt gtgcctgctg      420

aataactttt atccacggga ggctaaggtg cagtggaaag tggacaatgc cctccagagc      480

ggaaatagcc aagagtccgt taccgaacag gactctaaag actctacata ctccctgtcc      540

tccacactga ccctctccaa ggccgactat gagaaacaca aggtttacgc atgcgaggtc      600

acacaccagg gactctcctc tcccgtgacc aagagcttca accggggaga atgctaatga      660

attc                                                                   664


<210>  152
<211>  1363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   m3B8 heavy chain(nucleotide)

<400>  152
caggtccagc tgcaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcactg tctcagggtt ctcattaacc aactatgctg taagctgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagta atatggggtg acgggaccac aaattatcat      180

tcagctctca tatccagact gattatcagc aaggataact ccaagagcca agttttctta      240

aaactgaaca gtctgcaaac tgatgacaca gccacgtact actgtgccaa agagggcgac      300

tatggtgact acgtaggctg gtttgcttac tggggccaag ggactctggt cactgtctct      360

gcagccagca ctaaggggcc ctctgtgttt ccactcgccc cttctagcaa aagcacttcc      420

ggaggcactg cagcactcgg gtgtctggtc aaagattatt tccctgagcc agtcaccgtg      480

agctggaact ctggcgccct cacctccggg gttcacacct ttccagccgt cctgcagtcc      540

tccggcctgt actccctgag cagcgtcgtt accgtgccat cctcttctct ggggacccag      600

acatacatct gcaatgtcaa ccataagcct agcaacacca aggtggacaa aaaggtcgag      660

ccaaagagct gcgataagac acacacctgc cctccatgcc ccgcacctga actcctgggc      720

gggccttccg ttttcctgtt tcctcccaag cccaaggata cactgatgat tagccgcacc      780

cccgaagtca cttgcgtggt ggtggatgtg agccatgaag atccagaagt taagtttaac      840

tggtatgtgg acggggtcga ggtgcacaat gctaaaacaa agcccaggga ggagcaatat      900

aactccacat acagagtggt gtccgttctg acagtcctgc accaggactg gctgaacggg      960

aaggaataca agtgcaaggt gtctaataag gcactgccag cccccataga gaagacaatc     1020

tctaaagcta aaggccaacc acgcgagcct caggtctaca cactgccacc atccagggac     1080

gaactgacca agaatcaggt gagcctgact tgtctcgtca aaggattcta cccaagcgac     1140

atcgccgtgg agtgggaatc caacggccaa ccagagaaca actacaagac caccccacca     1200

gtcctggact ctgatgggag ctttttcctg tattccaagc tgacagtgga caagtctcgg     1260

tggcaacagg gcaacgtgtt cagctgctcc gtgatgcatg aagccctgca taaccactat     1320

acccagaaaa gcctcagcct gtcccccggg aaataatgaa ttc                       1363


