                         SEQUENCE LISTING

<110>  Nanjing Leads Biolabs Co.Ltd
 
<120>  ANTIBODY BINDING TIM-3 AND USE THEREOR

<130>  55534 00008

<150>  US62/656358
<151>  2018-04-12

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for TIM3-6

<400>  1

Ser Tyr Thr Ile Ser 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for TIM3-6.10, TIM3-6.11 and TIM3-6.12

<400>  2

Ser Tyr Thr Ile Tyr 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for TIM3-4G7

<400>  3

Ser Tyr Ala Met Ser 
1               5   


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for TIM3-11

<400>  4

Ser Asn Ser Ala Ala Trp Asn 
1               5           


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR 2 for TIM3-6

<400>  5

Arg Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for TIM3-6.10, TIM3-6.11 and TIM3-6.12

<400>  6

Ser Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for TIM3-4G7

<400>  7

Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for TIM3-11

<400>  8

Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val 
1               5                   10                  15      


Lys Ser 
        


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR 3 for TIM3-6, TIM3-6.10, TIM3-6.11 and TIM3-6.12

<400>  9

Ala Ser His Thr Ile 
1               5   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for TIM3-4G7

<400>  10

Ser Tyr Tyr Asp Asp Ala Phe Asp Ile 
1               5                   


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for TIM3-11

<400>  11

Asp Gln Ala Ala Gly Phe Pro Gln Pro Tyr Ile Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for TIM3-6

<400>  12

Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Ser Pro Asn 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for TIM3-6.10

<400>  13

Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Thr Pro Asn 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for TIM3-6.11 and TIM3-6.12

<400>  14

Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Thr Pro Asn 
1               5                   10                  


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for TIM3-4G7

<400>  15

Arg Ala Ser Gln Ser Val Thr Lys Asp Leu Val Ala 
1               5                   10          


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for TIM3-11

<400>  16

Thr Gly Asn Ser Asn Asn Val Gly Asn Gln Gly Ala Ala 
1               5                   10              


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR 2 for TIM3-6, TIM3-6.10, TIM3-6.11

<400>  17

Thr Thr Ser Asn Arg His Ser 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for TIM3-6.12

<400>  18

Thr Thr Asn Asn Arg His Ser 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for TIM3-4G7

<400>  19

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for TIM3-11

<400>  20

Arg Thr Asn Asn Arg Pro Ser 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR 3 for TIM3-6, TIM3-6.10, TIM3-6.11 and TIM3-6.12

<400>  21

Leu Leu Tyr Tyr Gly Gly Ala Trp Val 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for TIM3-4G7

<400>  22

Gln Gln Tyr Gly Arg Ser Pro Leu Thr 
1               5                   


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for TIM3-11

<400>  23

Ser Gly Trp Asp Ser Ser Leu Asn Glu Gly Val 
1               5                   10      


<210>  24
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for TIM3-6

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ala Ser His Thr Ile Trp Gly Lys Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  25
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for TIM3-6.10, TIM3-6.11 and TIM3-6.12

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ala Ser His Thr Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  26
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for TIM3-4G7

<400>  26

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Tyr Asp Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  27
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for TIM3-11

<400>  27

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Gln Ala Ala Gly Phe Pro Gln Pro Tyr Ile 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Lys Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125             


<210>  28
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for TIM3-6

<400>  28

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Ser Pro Asn Trp Phe Gln Gln Arg Pro Gly Gln Ala Pro Arg Ala 
        35                  40                  45              


Leu Ile Tyr Thr Thr Ser Asn Arg His Ser Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly 
                85                  90                  95      


Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  29
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for TIM3-6.10, TIM3-6.11 and TIM3-6.12


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X=N or Y

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  X=S or N

<400>  29

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Xaa Thr Pro Asn Trp Phe Gln Gln Arg Pro Gly Gln Ala Pro Arg Ala 
        35                  40                  45              


Leu Ile Tyr Thr Thr Xaa Asn Arg His Ser Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly 
                85                  90                  95      


Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  30
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for TIM3-4G7

<400>  30

Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Asp Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Lys Asp 
            20                  25                  30          


Leu Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Leu Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  31
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for TIM3-11

<400>  31

Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Lys Gly Leu Arg Gln 
1               5                   10                  15      


Thr Ala Thr Leu Thr Cys Thr Gly Asn Ser Asn Asn Val Gly Asn Gln 
            20                  25                  30          


Gly Ala Ala Trp Leu Gln Gln His Gln Gly His Pro Pro Lys Leu Leu 
        35                  40                  45              


Thr Tyr Arg Thr Asn Asn Arg Pro Ser Gly Ile Ser Glu Arg Phe Ser 
    50                  55                  60                  


Ala Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Gly Trp Asp Ser Ser Leu 
                85                  90                  95      


Asn Glu Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  32
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH for TIM3-6, TIM3-4G7 and TIM3-11

<400>  32

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  33
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH for TIM3-6.10, TIM3-6.11 and TIM3-6.12

<400>  33

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  34
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CL for TIM3-6 and TIM3-11

<400>  34

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 


<210>  35
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CL for TIM3-6.10, TIM3-6.11 and TIM3-6.12

<400>  35

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys 
            100                 


<210>  36
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CL for TIM3-4G7

<400>  36

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  37
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for TIM3-6

<400>  37
caggtgcagc tggtgcagtc tggcgccgag gtgaagaagc caggctccag cgtgaaggtg       60

tcctgcaagg cctccggcgg caccttctct tcctacacaa tctcctgggt gaggcaggct      120

ccaggacagg gactggagtg gatgggccgg atcatcccta tcctgggcac cgccaactac      180

gctcagaagt ttcagggcag agtgaccatc acagccgacg agtctacctc cacagcttat      240

atggagctga gctctctgcg ctccgaggat accgccgtgt actattgtgc ctccgcctcc      300

cacacaatct ggggcaaggg caccctggtg acagtgtcca gc                         342


<210>  38
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for TIM3-6.10, TIM3-6.11 and TIM3-6.12

<400>  38
caggtgcagc tggtgcagtc cggcgctgag gtgaagaagc ccggcagctc cgtgaaggtg       60

tcctgcaagg cctccggcgg caccttctcc tcctacacca tctactgggt gaggcaagcc      120

cctggccagg gactggagtg gatgggctcc atcatcccta tcctgggcac cgccaactac      180

gcccagaagt tccagggaag ggtgaccatc accgccgacg agagcacctc caccgcctac      240

atggagctgt cctccctgcg gtccgaggac accgctgtgt actactgcgc cagcgcttcc      300

cacaccatct ggggccaggg caccctggtg accgtgtcca gc                         342


<210>  39
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for TIM3-4G7

<400>  39
gaggtgcagc tggtggagac cggaggagga ctggtgcagc caggaggatc cctgagactg       60

agctgcgccg cttctggctt cacattttcc agctacgcta tgagctgggt gcgccaggct      120

cctggcaagg gactggagtg ggtgtctggc atcagcggct ctggcggctc tacctactat      180

gccgactccg tgaagggcag gttcaccaca tcccgggata acagcgagaa taccctgtat      240

ctgcagatga actccctgag ggccgaggac acagccgtgt actattgtgc cggctcctac      300

tatgacgatg cttttgatat ctggggccag ggcaccctgg tgacagtgtc ttcc            354


<210>  40
<211>  266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for TIM3-11

<400>  40
caggtgcagc tgcagcagag cggccctgga ctggtgaagc cttcccagac cctgtccctg       60

acctgcgcca tctccggcga ttccgtgtcc tccaacagcg ccgcctggaa ctggatcagg      120

cagagcccta gcaggggcct ggagtggctg ggaaggacct actaccggtc caagtggtac      180

aacgactacg ccgtgtccgt gaagtccagg atcaccatca accccgacac ctccaagaac      240

cagttctccc tgcagctgaa ctccgtgacc cccgaggaca ccgccgtgta ctactgtgcc      300

cgggatcagg ctgccggctt tcctcagcct tacatctacg gcatggacgt gtggggcaag      360

ggcaccatgg tgaccgtgtc ctcc                                             384



<210>  41
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for TIM3-6

<400>  41
caggccgtgg tgacccagga gccttccctg accgtgtccc ctggaggcac cgtgaccctg       60

acctgtgctt cctccacagg cgctgtgacc tccggctact cccccaactg gttccagcag      120

aggcctggcc aggctcctag ggctctgatc tacaccacct ccaacaggca ctcctggacc      180

cctgccaggt tctccggaag cctgctgggc ggaaaggctg ctctgacact gtccggcgtg      240

cagcctgaag acgaggccga ctactactgc ctgctgtact acggcggcgc ctgggtgttc      300

ggcggcggca ccaagctgac agtgctggga                                       330


<210>  42
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for TIM3-6.10

<400>  42
caggccgtgg tgacccagga gccaagcctg acagtgtctc caggaggaac cgtgacactg       60

acctgcgcct ccagcacagg cgctgtgacc tctggcaaca cacccaattg gttccagcag      120

aggccaggac aggctcctcg ggctctgatc tacaccacat ccaacagaca cagctggacc      180

cctgctcgct tttctggatc cctgctggga ggcaaggccg ctctgacact gtccggagtg      240

cagccagagg acgaggctga ttactattgt ctgctgtact atggaggagc ttgggtgttc      300

ggaggaggaa caaagctgac cgtgctgggc                                       330


<210>  43
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for TIM3-6.11

<400>  43
caggccgtgg tgacccagga gccaagcctg acagtgtctc caggaggaac cgtgacactg       60

acctgcgcct ccagcacagg cgctgtgacc tctggctaca cacccaactg gttccagcag      120

aggccaggac aggctcctcg ggctctgatc tataccacat ccaatagaca cagctggacc      180

cctgctcgct tttctggatc cctgctggga ggcaaggccg ctctgacact gtccggagtg      240

cagccagagg acgaggctga ttactattgt ctgctgtact atggaggagc ttgggtgttc      300

ggaggaggaa caaagctgac cgtgctgggc                                       330


<210>  44
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for TIM3-6.12

<400>  44
caggccgtgg tgacccagga gccaagcctg acagtgtctc caggaggaac cgtgacactg       60

acctgcgcct ccagcacagg cgctgtgacc tctggctaca cacccaactg gttccagcag      120

aggccaggac aggctcctcg ggctctgatc tataccacaa acaatagaca ctcctggacc      180

cctgctcgct tttctggatc cctgctggga ggcaaggccg ctctgacact gagcggagtg      240

cagccagagg acgaggctga ttactattgt ctgctgtact atggaggagc ttgggtgttc      300

ggaggaggaa caaagctgac cgtgctgggc                                       330


<210>  45
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for TIM3-4G7

<400>  45
gagaccaccc tgacccagtc ccccgctaca ctgtccctgt cccctggcga caccgccaca       60

ctgtcctgca gggcctccca gagcgtgacc aaggacctgg tggcctggta ccagcagagg      120

cctggacagg cccctaggct gctgctgtac ggcgcttcct ccagggccac aggcatccct      180

gataggttct ccggcagcgg ctccggcacc gatttcaccc tgaccatctc caggctggag      240

cccgaggact tcgccgtgta ctactgccag cagtacggca ggtcccccct gacctttgga      300

ggcggcacca aggtggagat caag                                             324


<210>  46
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for TIM3-11

<400>  46
ctgcccgtgc tgacccagcc tccttccgtg agcaagggcc tgaggcagac agccaccctg       60

acctgcaccg gcaactccaa caacgtgggc aaccagggcg ctgcttggct gcagcagcac      120

cagggccacc ctcctaagct gctgacctac aggaccaaca acaggccctc cggcatctcc      180

gagaggttct ccgcctctag gtccggcaac accgcctccc tgaccatcac cggactgcag      240

cccgaggacg aggccgacta ctactgctcc ggctgggaca gctccctgaa cgagggcgtg      300

ttcggcggcg gcaccaagct gacagtgctg gga                                   333


<210>  47
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH for TIM3-6, TIM3-4G7 and TIM3-11

<400>  47
gctagcacaa agggaccttc cgtgttccca ctggccccct gctccagaag cacatctgag       60

tccaccgccg ctctgggctg tctggtgaag gactacttcc ctgagccagt gaccgtgtcc      120

tggaacagcg gcgccctgac atccggagtg cacacctttc ccgccgtgct ccagtccagc      180

ggactgtaca gcctgtcttc cgtggtgaca gtgcccagct cttccctggg caccaagaca      240

tatacctgca acgtggacca taagcctagc aataccaagg tggataagag ggtggagtct      300

aagtacggac caccttgccc accatgtcca gctcctgagt ttctgggagg accatccgtg      360

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacacc tgaggtgacc      420

tgcgtggtgg tggacgtgtc ccaggaggac cccgaggtgc agttcaactg gtacgtggat      480

ggcgtggagg tgcacaatgc taagaccaag ccaagagagg agcagtttaa tagcacatac      540

cgcgtggtgt ctgtgctgac cgtgctgcat caggattggc tgaacggcaa ggagtataag      600

tgcaaggtga gcaataaggg cctgcccagc tctatcgaga agacaatctc taaggctaag      660

ggacagcctc gcgagccaca ggtgtacacc ctgccccctt cccaggagga gatgacaaag      720

aaccaggtga gcctgacctg tctggtgaag ggcttctatc catctgacat cgctgtggag      780

tgggagtcca acggccagcc cgagaacaat tacaagacca caccacccgt gctggactct      840

gatggctcct tctttctgta ttccaggctg acagtggata agagccggtg gcaggagggc      900

aacgtgttta gctgctctgt gatgcacgag gctctgcaca atcattatac ccagaagtcc      960

ctgagcctgt ctctgggcaa g                                                981


<210>  48
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH for TIM3-6.10, TIM3-6.11 and TIM3-6.12

<400>  48
gctagcacca agggaccatc cgtgttccca ctggccccct ccagcaagtc caccagcgga       60

ggaacagccg ctctgggatg cctggtgaag gactacttcc cagagcccgt gacagtgagc      120

tggaactctg gcgccctgac cagcggagtg cacacatttc ccgccgtgct ccagtcttcc      180

ggcctgtact ctctgagctc tgtggtgacc gtgccctcca gctctctggg cacccagaca      240

tatatctgca acgtgaatca caagccaagc aatacaaagg tggacaagaa ggtggagccc      300

aagtcttgtg ataagaccca tacatgcccc ccttgtcctg ctccagaggc tgctggagga      360

ccaagcgtgt tcctgtttcc acccaagcct aaggacaccc tgatgatctc caggaccccc      420

gaggtgacat gcgtggtggt ggctgtgagc cacgaggacc ccgaggtgaa gtttaactgg      480

tacgtggatg gcgtggaggt gcataatgct aagaccaagc ctagggagga gcagtacaac      540

tctacctatc gggtggtgtc cgtgctgaca gtgctgcacc aggactggct gaacggcaag      600

gagtataagt gcaaggtgtc taataaggcc ctggctgctc ctatcgagaa gaccatctcc      660

aaggccaagg gccagcctag agagccacag gtgtacacac tgcctccatc tcgcgacgag      720

ctgaccaaga accaggtgtc cctgacatgt ctggtgaagg gcttctatcc ttccgacatc      780

gctgtggagt gggagagcaa cggccagcca gagaacaatt acaagaccac accccctgtg      840

ctggactccg atggcagctt ctttctgtat agcaagctga ccgtggataa gtccaggtgg      900

cagcagggca acgtgttttc ttgctccgtg atgcatgagg ctctgcacaa tcattataca      960

cagaagagcc tgtctctgtc ccctggcaag tga                                   993


<210>  49
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CL for TIM3-6 and TIM3-11

<400>  49
cagcccaagg ctgccccttc cgtgaccctg tttcccccct cctccgagga gctgcaggcc       60

aacaaggcca ccctggtgtg cctgatctcc gacttctacc ctggcgctgt gaccgtggct      120

tggaaggccg attcctcccc tgtgaaggcc ggcgtggaga ccacaacccc ctccaagcag      180

tccaacaaca agtacgccgc ttcctcctac ctgtccctga cccccgagca gtggaagtcc      240

cacaggtcct actcctgcca ggtgacccac gagggctcca ccgtggagaa gacagtggcc      300

cccaccgagt gctcctga                                                    318


<210>  50
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CL for TIM3-4G7

<400>  50
cgtacggtgg ccgctccatc cgtgttcatc tttcccccta gcgacgagca gctgaagagc       60

ggcaccgcct ctgtggtgtg cctgctgaac aatttctacc ccagggaggc caaggtgcag      120

tggaaggtgg ataacgctct ccagagcggc aattctcagg agtccgtgac cgagcaggac      180

agcaaggatt ctacatattc cctgtccagc accctgacac tgtctaaggc cgactacgag      240

aagcacaagg tgtatgcttg cgaggtgaca catcagggcc tgtcttcccc cgtgacaaag      300

tcctttaacc ggggcgagtg ttga                                             324


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker peptide

<400>  51

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  52
<211>  654
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG control antibody

<400>  52

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
        115                 120                 125             


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
            180                 185                 190         


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Leu Gly Lys Asp Ile Arg Leu Thr Gln Ser Pro Ser 
        435                 440                 445             


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
    450                 455                 460                 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
465                 470                 475                 480 


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Gly Gly 
                485                 490                 495     


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
            500                 505                 510         


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln 
        515                 520                 525             


Gln Ser Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Thr 
    530                 535                 540                 


Val Leu Gly Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
545                 550                 555                 560 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
                565                 570                 575     


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
            580                 585                 590         


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
        595                 600                 605             


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
    610                 615                 620                 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
625                 630                 635                 640 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                645                 650                 


<210>  53
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of ABTIM3 analog

<400>  53

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Gly Ala Phe Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 


<210>  54
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of ABTIM3 analog

<400>  54

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Asp Pro Ser Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  55
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM3-mFc protein

<400>  55

Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp 
            20                  25                  30          


Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg 
        35                  40                  45              


Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn 
    50                  55                  60                  


Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr 
65                  70                  75                  80  


Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile 
                85                  90                  95      


Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys 
            100                 105                 110         


Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro 
        115                 120                 125             


Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu 
    130                 135                 140                 


Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn 
145                 150                 155                 160 


Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 
                165                 170                 175     


Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
            180                 185                 190         


Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 
        195                 200                 205             


Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val 
    210                 215                 220                 


His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
225                 230                 235                 240 


Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly 
                245                 250                 255     


Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 
            260                 265                 270         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val 
        275                 280                 285             


Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser 
    290                 295                 300                 


Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu 
305                 310                 315                 320 


Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro 
                325                 330                 335     


Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val 
            340                 345                 350         


Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu 
        355                 360                 365             


His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
    370                 375                 380                 


Pro Gly Lys 
385         


<210>  56
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain of Rituximab

<400>  56

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  57
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain of Rituximab

<400>  57

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


