                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
       Boga, Sobhana Babu
       Kekec, Ahmet
       Lin, Songnian
       Parish, Craig A.
       Tang, Weijuan
       Yan, Lin
 
<120>  AZIDE INSULIN AGONISTS

<130>  24573-WO-PCT

<150>  US 62/656,419
<151>  2018-04-12

<150>  US 62/674,325
<151>  2018-05-21

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  3
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin aspart B chain

<400>  3

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Asp Lys Thr 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin lispro B Chain

<400>  4

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin glargine A chain

<400>  5

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Gly 
            20      


<210>  6
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin glargine B chain

<400>  6

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin A chain mutiens


<220>
<221>  X8 is threonine or histidine
<222>  (8)..(8)

<220>
<221>  X17 is glutamic acid or glutamine
<222>  (17)..(17)

<220>
<221>  X19 is tyrosine, 4-methoxy-phenylalanine, or 4-amino 
       phenylalanine
<222>  (19)..(19)

<220>
<221>  X23 is sparagine or glycine
<222>  (21)..(21)

<400>  7

Gly Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Xaa Asn Xaa Cys Xaa 
            20      


<210>  8
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin B chain variants


<220>
<221>  X25 is histidine or threonine
<222>  (1)..(1)

<220>
<221>  X29 is alanine, glycine or serine
<222>  (5)..(5)

<220>
<221>  X30 is histidine, aspartic acid, glutamic acid, homocysteic acid,
       or cysteic acid
<222>  (6)..(6)

<220>
<221>  X31 is proline or lysine
<222>  (24)..(24)

<220>
<221>  X32 is proline or lysine, with the proviso that at least one of 
       X31 or X32 is lysine
<222>  (25)..(25)

<400>  8

Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Glu Arg Gly Phe Phe Tyr Thr Xaa Xaa 
            20                  25  


<210>  9
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin B chain variants


<220>
<221>  X22 is or phenylalanine and desamino-phenylalanine
<222>  (1)..(1)

<220>
<221>  X25 is histidine or threonine
<222>  (5)..(5)

<220>
<221>  X29 is alanine, glycine, or serine
<222>  (9)..(9)

<220>
<221>  X30 is histidine, aspartic acid, glutamic acid, homocysteic acid,
       or cysteic acid
<222>  (10)..(10)

<220>
<221>  X31 is aspartic acid, proline, or lysine
<222>  (28)..(28)

<220>
<221>  X32 is lysine or proline
<222>  (29)..(29)

<220>
<221>  X33 is threonine, alanine, or absent
<222>  (30)..(30)

<220>
<221>  X34 is arginine or absent
<222>  (31)..(31)

<220>
<221>  X35 is arginine or absent; With the proviso at least one of X31 
       or X32 is lysine
<222>  (32)..(32)

<400>  9

Xaa Val Asn Gln Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


