                         SEQUENCE LISTING

<110>  The Wistar Institute
       SOMASUNDARAM, Rajasekharan
       MUTHUMANI, Kar
       WEINER, David
 
<120>  ENGINEERED OPTIMIZED CYTOKINE COMPOSITIONS

<130>  Attorney Docket No. 368530-7015WO1(00083)

<150>  US 62/655,004
<151>  2018-04-09

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  510
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCSF-2

<400>  1
ggatccgcca ccatggactg gacttggatt ctgtttctgg tcgccgccgc aactcgcgtg       60

cattcaatgt ggctgcagag cctgctgctg ctggggactg tggcctgcag catctccgcc      120

cctgcacgga gccccagccc atccacccag ccatgggagc acgtgaacgc catccaggag      180

gcccggagac tgctgaatct gagcagggac accgccgccg agatgaacga gacagtggaa      240

gtgatctccg agatgttcga tctgcaggag cccacctgtc tgcagacaag gctggagctg      300

tacaagcagg gcctgagggg ctccctgacc aagctgaagg gacccctgac aatgatggcc      360

tctcactata agcagcactg ccctcccacc cctgagacat cttgtgccac ccagatcatc      420

acattcgaga gctttaagga aaacctgaag gactttctgc tggtcatccc ctttgattgc      480

tgggaacccg tgcaggagta atgactcgag                                       510


<210>  2
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCSF-2

<400>  2

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys 
            20                  25                  30          


Ser Ile Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp 
        35                  40                  45              


Glu His Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser 
    50                  55                  60                  


Arg Asp Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu 
65                  70                  75                  80  


Met Phe Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu 
                85                  90                  95      


Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu 
            100                 105                 110         


Thr Met Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu 
        115                 120                 125             


Thr Ser Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn 
    130                 135                 140                 


Leu Lys Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val 
145                 150                 155                 160 


Gln Glu 
        


<210>  3
<211>  531
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hIL-3

<400>  3
ggatccgcca ccatggattg gacctggatt ctgtttctgg tcgctgctgc tacaagagtg       60

cattcctcac gcctgcctgt cctgctgctg ctgcagctgc tggtgcggcc cggcctgcag      120

gcacctatga cccagaccac acctctgaag acatcttggg tgaactgcag caatatgatc      180

gacgagatca tcacccacct gaagcagccc cctctgccac tgctggattt caacaatctg      240

aacggcgagg accaggatat cctgatggag aacaatctga gacggcccaa cctggaggcc      300

tttaatcggg ccgtgaagag cctgcagaac gccagcgcca tcgagtccat cctgaagaat      360

ctgctgccat gtctgccact ggcaaccgca gcacctacaa ggcacccaat ccacatcaag      420

gacggcgatt ggaatgagtt caggcgcaag ctgacatttt acctgaaaac actggagaac      480

gcacaggcac agcagactac actgagcctg gcaatcttct aatgactcga g               531


<210>  4
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIL-3

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg 
            20                  25                  30          


Pro Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser 
        35                  40                  45              


Trp Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys 
    50                  55                  60                  


Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp 
65                  70                  75                  80  


Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala 
                85                  90                  95      


Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser 
            100                 105                 110         


Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro 
        115                 120                 125             


Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg 
    130                 135                 140                 


Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln 
145                 150                 155                 160 


Gln Thr Thr Leu Ser Leu Ala Ile Phe 
                165                 


<210>  5
<211>  606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hIL-7

<400>  5
ggatccgcca ccatggactg gacttggatt ctgttcctgg tcgctgccgc tacacgagtg       60

cattcatttc acgtctcttt tcgctacatc ttcgggctgc cccctctgat cctggtgctg      120

ctgccagtgg ccagctccga ctgcgatatc gagggcaagg acggcaagca gtacgagtct      180

gtgctgatgg tgagcatcga ccagctgctg gattccatga aggagatcgg ctctaactgc      240

ctgaacaatg agttcaattt ctttaagcgc cacatctgtg atgccaacaa ggagggcatg      300

ttcctgtttc gggccgccag aaagctgagg cagttcctga agatgaattc taccggcgac      360

tttgatctgc acctgctgaa ggtgtccgag ggcaccacaa tcctgctgaa ctgcaccgga      420

caggtgaagg gaaggaagcc agccgccctg ggagaggccc agcccacaaa gagcctggag      480

gagaacaagt ccctgaagga gcagaagaag ctgaatgacc tgtgcttcct gaagagactg      540

ctgcaggaga ttaagacatg ctggaacaag attctgatgg gaactaagga acactaatga      600

ctcgag                                                                 606


<210>  6
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIL-7

<400>  6

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu 
            20                  25                  30          


Ile Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly 
        35                  40                  45              


Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln 
    50                  55                  60                  


Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu 
65                  70                  75                  80  


Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met 
                85                  90                  95      


Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn 
            100                 105                 110         


Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr 
        115                 120                 125             


Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala 
    130                 135                 140                 


Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser 
145                 150                 155                 160 


Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu 
                165                 170                 175     


Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys 
            180                 185                 190         


Glu His 
        


<210>  7
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hSCF 

<400>  7
ggatccgcca ccatggactg gacttggatt ctgttcctgg tcgctgctgc cacccgagtg       60

cattcaaaaa agactcagac ttggattctg acttgtattt acctgcagct gctgctgttc      120

aacccactgg tgaagaccga gggcatctgc aggaatagag tgaccaacaa tgtgaaggac      180

gtgacaaagc tggtggccaa cctgcccaag gattacatga tcaccctgaa gtatgtgcct      240

ggcatggacg tgctgccatc ccactgttgg atctctgaga tggtggtgca gctgagcgat      300

tccctgacag acctgctgga taagttttct aacatcagcg agggcctgtc caattattct      360

atcatcgaca agctggtgaa catcgtggac gatctggtgg agtgcgtgaa ggagaatagc      420

tccaaggatc tgaagaagag cttcaagtcc ccagagccca ggctgtttac ccctgaggag      480

ttctttcgga tcttcaaccg ctctatcgac gccttcaagg attttgtggt ggcctctgag      540

acaagcgact gcgtggtgag cagcaccctg tcccccgaga agggcaaggc caagaatccc      600

cctggcgatt cctctctgca ctgggcagca atggcactgc ccgccctgtt tagcctgatc      660

atcggcttcg cctttggcgc cctgtactgg aagaagaggc agccttccct gacacgggcc      720

gtggagaata tccagatcaa cgaagaagat aatgagattt caatgctgca ggagaaggag      780

agggaatttc aggaagtctg ataactcgag                                       810


<210>  8
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hSCF 

<400>  8

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln 
            20                  25                  30          


Leu Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn 
        35                  40                  45              


Arg Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu 
    50                  55                  60                  


Pro Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val 
65                  70                  75                  80  


Leu Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp 
                85                  90                  95      


Ser Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu 
            100                 105                 110         


Ser Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu 
        115                 120                 125             


Val Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe 
    130                 135                 140                 


Lys Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile 
145                 150                 155                 160 


Phe Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu 
                165                 170                 175     


Thr Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Gly Lys 
            180                 185                 190         


Ala Lys Asn Pro Pro Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala 
        195                 200                 205             


Leu Pro Ala Leu Phe Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu 
    210                 215                 220                 


Tyr Trp Lys Lys Arg Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile 
225                 230                 235                 240 


Gln Ile Asn Glu Glu Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu 
                245                 250                 255     


Arg Glu Phe Gln Glu Val 
            260         


<210>  9
<211>  3054
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLT3

<400>  9
ggatccgcca ccatggactg gacatggatt ctgttcctgg tggccgccgc caccagggtg       60

cactcccccg ccctggccag gggcggcggc cagctgcctc tgctggtggt gttctctgcc      120

atgatctttg gcaccatcac aaaccaggat ctgcccgtga tcaagtgcgt gctgatcaac      180

cacaagaaca atgacagctc cgtgggcaag tctagctcct accccatggt gtccgagtct      240

cctgaggatc tgggatgcgc actgaggcct cagtctagcg gaacagtgta tgaggcagca      300

gcagtggagg tggatgtgag cgcctccatc accctgcagg tgctggtgga cgcacctggc      360

aacatctcct gcctgtgggt gttcaagcac tcctctctga actgtcagcc acactttgac      420

ctgcagaata gaggcgtggt gagcatggtc atcctgaaga tgaccgagac acaggccggc      480

gagtacctgc tgttcatcca gtccgaggcc accaactata caatcctgtt taccgtgtct      540

atcaggaata cactgctgta caccctgagg aggccctatt tcagaaagat ggagaatcag      600

gatgccctgg tgtgcatctc tgagagcgtg cccgagccta tcgtggagtg ggtgctgtgc      660

gactcccagg gcgagtcttg taaggaggag agccccgccg tggtgaagaa ggaggagaag      720

gtgctgcacg agctgttcgg catggatatc aggtgctgtg caaggaacga gctgggaagg      780

gagtgtacaa gactgttcac catcgacctg aatcagacac cacagaccac actgccccag      840

ctgtttctga aagtgggcga gcctctgtgg atcaggtgca aggccgtgca cgtgaaccac      900

ggcttcggcc tgacctggga gctggagaac aaggccctgg aggagggcaa ttactttgag      960

atgagcacct attccacaaa ccggaccatg atccgcatcc tgttcgcctt tgtgagctcc     1020

gtggcccgga atgatacagg ctactatacc tgttctagct ccaagcaccc atcccagtct     1080

gccctggtga caatcgtgga gaagggcttc atcaacgcca ccaattctag cgaggactac     1140

gagatcgatc agtatgagga gttctgcttt agcgtgcgct ttaaggccta cccacagatc     1200

cggtgcacct ggacattctc tcgcaagagc tttccctgtg agcagaaggg cctggacaac     1260

ggctacagca tctccaagtt ctgtaatcac aagcaccagc ctggcgagta tatctttcac     1320

gccgagaacg acgatgccca gttcacaaag atgtttaccc tgaatatcag gaggaagcca     1380

caggtgctgg cagaggcatc tgccagccag gcctcctgct tctctgatgg ctacccactg     1440

ccctcctgga catggaagaa gtgcagcgac aagtccccaa actgtacaga ggagatcacc     1500

gagggcgtgt ggaacaggaa ggccaataga aaggtgttcg gccagtgggt gtcctctagc     1560

accctgaaca tgagcgaggc catcaagggc tttctggtga agtgctgtgc ctacaatagc     1620

ctgggcacat cctgcgagac aatcctgctg aacagccctg gcccattccc ctttatccag     1680

gacaatatct ccttctatgc cacaatcggc gtgtgcctgc tgtttatcgt ggtgctgacc     1740

ctgctgatct gtcacaagta caagaagcag ttcagatatg agtcccagct gcagatggtg     1800

caggtgaccg gctcctctga caacgagtac ttctatgtgg attttcggga gtacgagtat     1860

gacctgaagt gggagttccc ccgcgagaac ctggagtttg gcaaggtgct gggcagcgga     1920

gccttcggca aagtgatgaa tgccacagcc tacggcatca gcaagaccgg cgtgtccatc     1980

caggtggccg tgaagatgct gaaggagaag gccgatagct ccgagcggga ggccctgatg     2040

tctgagctga agatgatgac acagctgggc agccacgaga acatcgtgaa tctgctgggc     2100

gcctgtaccc tgtctggccc tatctacctg atcttcgagt actgctgtta tggcgacctg     2160

ctgaactatc tgaggagcaa gagagagaag ttccacagga cctggacaga gatctttaag     2220

gagcacaact tctcctttta cccaaccttc cagtctcacc ctaattctag catgccaggc     2280

tccagagagg tgcagatcca ccccgactct gatcagatca gcggcctgca cggcaattct     2340

tttcacagcg aggacgagat cgagtacgag aaccagaagc ggctggagga ggaggaggat     2400

ctgaatgtgc tgacattcga ggacctgctg tgctttgcct atcaggtggc caagggcatg     2460

gagttcctgg agtttaagag ctgcgtgcac agggatctgg ccgccagaaa cgtgctggtg     2520

acccacggca aggtggtgaa gatctgcgac ttcggcctgg cccgcgacat catgtccgat     2580

tctaactacg tggtgcgggg aaatgcaagg ctgccagtga agtggatggc accagagtcc     2640

ctgtttgagg gcatctacac aatcaagtcc gacgtgtggt cttatggcat cctgctgtgg     2700

gagatcttct ctctgggcgt gaacccttac ccaggcatcc ccgtggatgc caacttttat     2760

aagctgatcc agaatggctt caagatggac cagccttttt acgccacaga ggagatctat     2820

atcatcatgc agagctgctg ggccttcgac tctcggaagc gccccagctt ccctaatctg     2880

acctcctttc tgggatgtca gctggcagat gcagaggagg ccatgtacca gaacgtggac     2940

ggccgggtgt ctgagtgccc tcacacctat cagaatagga ggcccttcag cagggagatg     3000

gatctgggcc tgctgagccc ccaggcacag gtggaggact cctgataact cgag           3054


<210>  10
<211>  1010
<212>  PRT
<213> Artificial Sequence

<220>
<223>  FLT3

<400>  10

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Pro Ala Leu Ala Arg Gly Gly Gly Gln Leu Pro Leu Leu Val 
            20                  25                  30          


Val Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro 
        35                  40                  45              


Val Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val 
    50                  55                  60                  


Gly Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu 
65                  70                  75                  80  


Gly Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala 
                85                  90                  95      


Ala Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val 
            100                 105                 110         


Asp Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser 
        115                 120                 125             


Leu Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser 
    130                 135                 140                 


Met Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu 
145                 150                 155                 160 


Phe Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser 
                165                 170                 175     


Ile Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys 
            180                 185                 190         


Met Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu 
        195                 200                 205             


Pro Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys 
    210                 215                 220                 


Glu Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu 
225                 230                 235                 240 


Leu Phe Gly Met Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg 
                245                 250                 255     


Glu Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr 
            260                 265                 270         


Thr Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg 
        275                 280                 285             


Cys Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu 
    290                 295                 300                 


Glu Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr 
305                 310                 315                 320 


Ser Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser 
                325                 330                 335     


Val Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His 
            340                 345                 350         


Pro Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn 
        355                 360                 365             


Ala Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe 
    370                 375                 380                 


Cys Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp 
385                 390                 395                 400 


Thr Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn 
                405                 410                 415     


Gly Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu 
            420                 425                 430         


Tyr Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe 
        435                 440                 445             


Thr Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala 
    450                 455                 460                 


Ser Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr 
465                 470                 475                 480 


Trp Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr 
                485                 490                 495     


Glu Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp 
            500                 505                 510         


Val Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu 
        515                 520                 525             


Val Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile 
    530                 535                 540                 


Leu Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser 
545                 550                 555                 560 


Phe Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr 
                565                 570                 575     


Leu Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln 
            580                 585                 590         


Leu Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr 
        595                 600                 605             


Val Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg 
    610                 615                 620                 


Glu Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys 
625                 630                 635                 640 


Val Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile 
                645                 650                 655     


Gln Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg 
            660                 665                 670         


Glu Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His 
        675                 680                 685             


Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile 
    690                 695                 700                 


Tyr Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu 
705                 710                 715                 720 


Arg Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys 
                725                 730                 735     


Glu His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser 
            740                 745                 750         


Ser Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln 
        755                 760                 765             


Ile Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu 
    770                 775                 780                 


Tyr Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu 
785                 790                 795                 800 


Thr Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met 
                805                 810                 815     


Glu Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg 
            820                 825                 830         


Asn Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly 
        835                 840                 845             


Leu Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn 
    850                 855                 860                 


Ala Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly 
865                 870                 875                 880 


Ile Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp 
                885                 890                 895     


Glu Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp 
            900                 905                 910         


Ala Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro 
        915                 920                 925             


Phe Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala 
    930                 935                 940                 


Phe Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu 
945                 950                 955                 960 


Gly Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp 
                965                 970                 975     


Gly Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe 
            980                 985                 990         


Ser Arg Glu Met Asp Leu Gly Leu  Leu Ser Pro Gln Ala  Gln Val Glu 
        995                 1000                 1005             


Asp Ser  
    1010 


<210>  11
<211>  1134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hTPO 

<400>  11
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggcagcagc aacccgggtg       60

cactccgagc tgacagagct gctgctggtg gtcatgctgc tgctgacagc aaggctgacc      120

ctgagctccc cagcccctcc cgcatgcgac ctgcgggtgc tgtccaagct gctgcgcgat      180

tctcacgtgc tgcactcccg gctgtctcag tgtccagagg tgcacccact gcctacccca      240

gtgctgctgc cagccgtgga ctttagcctg ggcgagtgga agacccagat ggaggagaca      300

aaggcccagg atatcctggg agcagtgacc ctgctgctgg agggcgtgat ggcagccagg      360

ggccagctgg gccccacatg cctgtctagc ctgctgggac agctgtccgg acaggtgagg      420

ctgctgctgg gcgccctgca gtctctgctg ggaacccagc tgccacccca gggaagaacc      480

acagcccaca aggaccccaa cgccatcttc ctgagctttc agcacctgct gaggggcaag      540

gtgagattcc tgatgctggt gggcggcagc accctgtgcg tgaggagagc ccctccaacc      600

acagccgtgc ctagcaggac ctccctggtg ctgacactga acgagctgcc aaatagaaca      660

tctggcctgc tggagacaaa cttcaccgca agcgccagga ccacaggctc cggcctgctg      720

aagtggcagc agggctttcg ggccaagatc cccggcctgc tgaatcagac cagccgctcc      780

ctggaccaga tccctggcta cctgaacaga atccacgagc tgctgaatgg caccagaggc      840

ctgttcccag gacctagccg gcgcacactg ggagcacctg acatctcctc tggcacatct      900

gataccggca gcctgccccc taatctgcag ccaggctact ctccaagccc aacacaccca      960

cccaccggac agtatacact gtttccactg cctccaacac tgcctacccc agtggtgcag     1020

ctgcacccac tgctgcccga tccttctgcc ccaaccccca cacctaccag ccctctgctg     1080

aacacatcct atacccactc tcagaatctg agccaggagg gctgataact cgag           1134


<210>  12
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTPO 

<400>  12

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Glu Leu Thr Glu Leu Leu Leu Val Val Met Leu Leu Leu Thr 
            20                  25                  30          


Ala Arg Leu Thr Leu Ser Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg 
        35                  40                  45              


Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu 
    50                  55                  60                  


Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro 
65                  70                  75                  80  


Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr 
                85                  90                  95      


Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val 
            100                 105                 110         


Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu 
        115                 120                 125             


Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser 
    130                 135                 140                 


Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys 
145                 150                 155                 160 


Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys 
                165                 170                 175     


Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Arg 
            180                 185                 190         


Ala Pro Pro Thr Thr Ala Val Pro Ser Arg Thr Ser Leu Val Leu Thr 
        195                 200                 205             


Leu Asn Glu Leu Pro Asn Arg Thr Ser Gly Leu Leu Glu Thr Asn Phe 
    210                 215                 220                 


Thr Ala Ser Ala Arg Thr Thr Gly Ser Gly Leu Leu Lys Trp Gln Gln 
225                 230                 235                 240 


Gly Phe Arg Ala Lys Ile Pro Gly Leu Leu Asn Gln Thr Ser Arg Ser 
                245                 250                 255     


Leu Asp Gln Ile Pro Gly Tyr Leu Asn Arg Ile His Glu Leu Leu Asn 
            260                 265                 270         


Gly Thr Arg Gly Leu Phe Pro Gly Pro Ser Arg Arg Thr Leu Gly Ala 
        275                 280                 285             


Pro Asp Ile Ser Ser Gly Thr Ser Asp Thr Gly Ser Leu Pro Pro Asn 
    290                 295                 300                 


Leu Gln Pro Gly Tyr Ser Pro Ser Pro Thr His Pro Pro Thr Gly Gln 
305                 310                 315                 320 


Tyr Thr Leu Phe Pro Leu Pro Pro Thr Leu Pro Thr Pro Val Val Gln 
                325                 330                 335     


Leu His Pro Leu Leu Pro Asp Pro Ser Ala Pro Thr Pro Thr Pro Thr 
            340                 345                 350         


Ser Pro Leu Leu Asn Thr Ser Tyr Thr His Ser Gln Asn Leu Ser Gln 
        355                 360                 365             


Glu Gly 
    370 


<210>  13
<211>  1737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCSF-1 

<400>  13
ggatccgcca ccatggattg gacctggatt ctgtttctgg tcgcagcagc aactcgcgtg       60

cattcaaccg ctcctggggc agccggaaga tgtcctccta ccacatggct gggcagcctg      120

ctgctgctgg tgtgcctgct ggccagcaga tccatcaccg aggaggtgtc tgagtactgt      180

agccacatga tcggctccgg acacctgcag tctctgcagc ggctgatcga cagccagatg      240

gagacaagct gccagatcac attcgagttt gtggaccagg agcagctgaa ggaccccgtg      300

tgctatctga agaaggcctt cctgctggtg caggacatca tggaggatac catgcgcttt      360

agggataaca cacctaatgc catcgccatc gtgcagctgc aggagctgtc tctgagactg      420

aagagctgct tcaccaagga ctacgaggag cacgataagg cctgcgtgag gaccttctac      480

gagacacctc tgcagctgct ggagaaggtg aagaacgtgt tcaatgagac aaagaacctg      540

ctggacaagg attggaacat cttcagcaag aattgcaaca attcctttgc cgagtgtagc      600

tcccaggacg tggtgacaaa gccagattgc aattgtctgt accctaaggc catcccatct      660

agcgaccccg catctgtgag cccccaccag cctctggcac catccatggc accagtggca      720

ggcctgacct gggaggactc tgagggcaca gagggctcct ctctgctgcc tggagagcag      780

ccactgcaca ccgtggaccc cggctccgcc aagcagaggc ctcccaggag cacatgccag      840

tcttttgagc cacccgagac accagtggtg aaggattcca caatcggcgg ctctccccag      900

cctaggccat ccgtgggagc cttcaaccca ggaatggagg acatcctgga tagcgccatg      960

ggcaccaatt gggtgcctga ggaggcaagc ggagaggcat ccgagatccc agtgcctcag     1020

ggaaccgagc tgtcccccag caggcccggc ggcggcagca tgcagacaga gccagccagg     1080

ccctctaact ttctgagcgc cagctcccca ctgccagcaa gcgccaaggg acagcagcca     1140

gccgacgtga ccggaacagc cctgcctaga gtgggacctg tgcggccaac aggacaggat     1200

tggaaccaca cccctcagaa gacagaccac ccttctgccc tgctgcgcga tcctccagag     1260

ccaggcagcc ctcgcatctc tagcctgagg ccacagggcc tgtctaatcc aagcaccctg     1320

tccgcccagc ctcagctgag ccgctcccac tcctctggca gcgtgctgcc actgggagag     1380

ctggagggca ggagatctac aagggaccgg cgcagcccag ccgagcccga gggcggccca     1440

gcaagcgagg gagcagcccg ccctctgcca aggttcaatt ccgtgcccct gaccgataca     1500

ggccacgaga gacagtctga gggcagctcc tctccacagc tgcaggagtc cgtgtttcac     1560

ctgctggtgc cctctgtgat cctggtgctg ctggcagtgg gcggcctgct gttctataga     1620

tggaggagac ggagccacca ggagcctcag cgggccgact ccccactgga acagcccgaa     1680

ggaagccctc tgactcagga tgaccgacag gtggaactgc ccgtgtaatg actcgag        1737


<210>  14
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCSF-1 

<400>  14

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp 
            20                  25                  30          


Leu Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile 
        35                  40                  45              


Thr Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His 
    50                  55                  60                  


Leu Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys 
65                  70                  75                  80  


Gln Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val 
                85                  90                  95      


Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp 
            100                 105                 110         


Thr Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln 
        115                 120                 125             


Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr 
    130                 135                 140                 


Glu Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu 
145                 150                 155                 160 


Gln Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu 
                165                 170                 175     


Leu Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe 
            180                 185                 190         


Ala Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys 
        195                 200                 205             


Leu Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro 
    210                 215                 220                 


His Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp 
225                 230                 235                 240 


Glu Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln 
                245                 250                 255     


Pro Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg 
            260                 265                 270         


Ser Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp 
        275                 280                 285             


Ser Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe 
    290                 295                 300                 


Asn Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp 
305                 310                 315                 320 


Val Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln 
                325                 330                 335     


Gly Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr 
            340                 345                 350         


Glu Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro 
        355                 360                 365             


Ala Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu 
    370                 375                 380                 


Pro Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr 
385                 390                 395                 400 


Pro Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu 
                405                 410                 415     


Pro Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn 
            420                 425                 430         


Pro Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser 
        435                 440                 445             


Gly Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg 
    450                 455                 460                 


Asp Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly 
465                 470                 475                 480 


Ala Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr 
                485                 490                 495     


Gly His Glu Arg Gln Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln Glu 
            500                 505                 510         


Ser Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala 
        515                 520                 525             


Val Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu 
    530                 535                 540                 


Pro Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu 
545                 550                 555                 560 


Thr Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
                565                 570     


<210>  15
<211>  588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCSF-3 

<400>  15
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggcagcagc aaccagggtg       60

cacagcgccg gccccgccac acagtcccct atgaagctga tggccctgca gctgctgctg      120

tggcactctg ccctgtggac cgtgcaggag gcaacacccc tgggacctgc cagctccctg      180

ccacagagct ttctgctgaa gtgcctggag caggtgcgga agatccaggg cgacggagcc      240

gccctgcagg agaagctggt gagcgaggcc ggctgtctgt ctcagctgca cagcggcctg      300

ttcctgtacc agggactgct gcaggccctg gagggaatct ccccagagct gggacccacc      360

ctggatacac tgcagctgga cgtggccgat tttgccacca caatctggca gcagatggag      420

gagctgggaa tggcacctgc cctgcagcca acacagggag caatgccagc cttcgcctcc      480

gcctttcaga ggagagccgg cggcgtgctg gtggcatccc acctgcagtc tttcctggag      540

gtgtcttatc gggtgctgcg ccacctggcc cagccctaat gactcgag                   588


<210>  16
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCSF-3 

<400>  16

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu 
            20                  25                  30          


Gln Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr 
        35                  40                  45              


Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys 
    50                  55                  60                  


Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu 
65                  70                  75                  80  


Lys Leu Val Ser Glu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 
                85                  90                  95      


Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 
            100                 105                 110         


Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 
        115                 120                 125             


Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 
    130                 135                 140                 


Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 
145                 150                 155                 160 


Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 
                165                 170                 175     


Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
            180                 185             


<210>  17
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hEPO 

<400>  17
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggcagcagc aacaagggtg       60

cacagcggag tgcacgagtg cccagcatgg ctgtggctgc tgctgtctct gctgagcctg      120

ccactgggac tgcctgtgct gggagcccct cccaggctga tctgtgactc tagggtgctg      180

gagagatacc tgctggaggc caaggaggcc gagaacatca ccacaggctg cgccgagcac      240

tgtagcctga acgagaatat caccgtgccc gatacaaagg tgaacttcta cgcctggaag      300

aggatggaag tgggacagca ggcagtggaa gtgtggcagg gcctggccct gctgtccgag      360

gccgtgctga ggggacaggc cctgctggtg aacagctccc agccttggga gccactgcag      420

ctgcacgtgg acaaggccgt gtccggactg cggtctctga ccacactgct gcgcgccctg      480

ggagcacaga aggaggcaat cagcccaccc gacgcagcat ccgccgcccc tctgaggacc      540

atcacagcag ataccttccg gaagctgttt cgcgtgtact ctaatttcct gagaggcaag      600

ctgaagctgt ataccggcga ggcctgcagg acaggcgata gataatgact cgag            654


<210>  18
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hEPO 

<400>  18

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser 
            20                  25                  30          


Leu Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg 
        35                  40                  45              


Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys 
    50                  55                  60                  


Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn 
65                  70                  75                  80  


Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys 
                85                  90                  95      


Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala 
            100                 105                 110         


Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser 
        115                 120                 125             


Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser 
    130                 135                 140                 


Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys 
145                 150                 155                 160 


Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr 
                165                 170                 175     


Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe 
            180                 185                 190         


Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly 
        195                 200                 205             


Asp Arg 
    210 


<210>  19
<211>  3006
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-kit 

<400>  19
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggccgctgc cacaagggtg       60

cacagcatgc ggggcgctcg cggagcctgg gatttcctgt gcgtgctgct gctgctgctg      120

agagtgcaga ccggcagctc ccagccatct gtgagcccag gagagccaag ccctccctcc      180

atccaccctg gcaagtccga cctgatcgtg agggtgggag atgagatcag actgctgtgc      240

accgacccag gctttgtgaa gtggaccttc gagatcctgg atgagacaaa cgagaacaag      300

cagaacgagt ggatcacaga gaaggctgag gccacaaaca ccggcaagta cacatgtacc      360

aacaagcacg gactgtccaa ctctatctac gtgtttgtgc gggaccccgc caagctgttc      420

ctggtggatc gctctctgta cggcaaggag gacaacgata ccctggtgcg gtgccctctg      480

accgacccag aggtgacaaa ctacagcctg aagggctgtc agggaaagcc tctgccaaag      540

gacctgcgct tcatccccga tcctaaggct ggaatcatga tcaagtctgt gaagagggcc      600

taccacagac tgtgcctgca ctgtagcgtg gatcaggagg gcaagtctgt gctgagcgag      660

aagtttatcc tgaaggtgcg gccagctttc aaggctgtgc cagtggtgag cgtgtccaag      720

gcctcctacc tgctgcgcga gggagaggag tttacagtga cctgcacaat caaggacgtg      780

tctagctccg tgtacagcac ctggaagcgg gagaactccc agacaaagct gcaggagaag      840

tacaactctt ggcaccacgg cgacttcaac tacgagaggc aggctaccct gacaatctct      900

agcgccagag tgaacgattc cggcgtgttc atgtgctacg ctaacaacac cttcggctct      960

gccaacgtga ccacaaccct ggaggtggtg gacaagggct tcatcaacat cttccccatg     1020

atcaacacaa ccgtgttcgt gaacgacggc gagaacgtgg atctgatcgt ggagtacgag     1080

gcctttccaa agcccgagca ccagcagtgg atctacatga acaggacctt cacagacaag     1140

tgggaggatt accctaagag cgagaacgag tccaacatca gatacgtgag cgagctgcac     1200

ctgaccagac tgaagggaac agagggcgga acctacacat ttctggtgtc taacagcgac     1260

gtgaacgctg ccatcgcttt caacgtgtac gtgaacacca agcccgagat cctgacatac     1320

gatcggctgg tgaacggcat gctgcagtgc gtggctgccg gatttcctga gccaaccatc     1380

gactggtact tctgccctgg cacagagcag aggtgctccg cctctgtgct gccagtggat     1440

gtgcagaccc tgaactcctc tggcccaccc tttggaaagc tggtggtgca gagctccatc     1500

gacagcagcg ccttcaagca caacggaacc gtggagtgca aggcctacaa cgatgtgggc     1560

aagaccagcg cctacttcaa ctttgccttc aagggaaaca acaaggagca gatccaccct     1620

cacaccctgt ttacaccact gctgatcggc ttcgtgatcg tggccggaat gatgtgcatc     1680

atcgtgatga tcctgacata caagtacctg cagaagccaa tgtacgaggt gcagtggaaa     1740

gtggtggagg agatcaacgg caacaactac gtgtacatcg accccaccca gctgccttac     1800

gatcacaagt gggagtttcc caggaacaga ctgtccttcg gcaagacact gggcgctgga     1860

gccttcggaa aggtggtgga ggctaccgcc tacggcctga tcaagtctga cgctgccatg     1920

acagtggctg tgaagatgct gaagcctagc gcccacctga ccgagaggga ggccctgatg     1980

tctgagctga aggtgctgag ctacctggga aaccacatga acatcgtgaa cctgctggga     2040

gcttgcacaa tcggcggacc caccctggtc atcacagagt actgctgtta cggcgacctg     2100

ctgaactttc tgaggagaaa gagagactct ttcatctgca gcaagcagga ggatcacgct     2160

gaggctgccc tgtacaagaa cctgctgcac agcaaggagt cctcttgtag cgactccacc     2220

aacgagtaca tggatatgaa gccaggagtg tcctacgtgg tgcccacaaa ggctgacaag     2280

cggcgcagcg tgcggatcgg ctcctacatc gagcgcgatg tgacccctgc tatcatggag     2340

gacgatgagc tggccctgga cctggaggat ctgctgtctt ttagctacca ggtggctaag     2400

ggcatggctt tcctggcctc caagaactgc atccaccggg acctggctgc ccgcaacatc     2460

ctgctgaccc acggaaggat cacaaagatc tgtgattttg gcctggccag agacatcaag     2520

aacgattcca actacgtggt gaagggaaac gctagactgc ccgtgaagtg gatggcccct     2580

gagtctatct ttaactgcgt gtacaccttc gagtccgacg tgtggtctta cggcatcttt     2640

ctgtgggagc tgttcagcct gggcagctcc ccctaccctg gaatgcctgt ggattccaag     2700

ttttacaaga tgatcaagga gggcttcagg atgctgagcc cagagcacgc tccagctgag     2760

atgtacgaca tcatgaagac ctgctgggac gccgatcctc tgaagagacc aacattcaag     2820

cagatcgtgc agctgatcga gaagcagatc tccgagtcta ccaaccacat ctactccaac     2880

ctggctaact gttctcccaa ccggcagaag cctgtggtgg accactccgt gcgcatcaac     2940

tccgtgggct ctacagcctc tagctcccag ccactgctgg tgcacgacga tgtgtaatga     3000

ctcgag                                                                3006


<210>  20
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-kit 

<400>  20

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu 
            20                  25                  30          


Leu Leu Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser 
        35                  40                  45              


Pro Gly Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu 
    50                  55                  60                  


Ile Val Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly 
65                  70                  75                  80  


Phe Val Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys 
                85                  90                  95      


Gln Asn Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys 
            100                 105                 110         


Tyr Thr Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe 
        115                 120                 125             


Val Arg Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly 
    130                 135                 140                 


Lys Glu Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu 
145                 150                 155                 160 


Val Thr Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys 
                165                 170                 175     


Asp Leu Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser 
            180                 185                 190         


Val Lys Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln 
        195                 200                 205             


Glu Gly Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro 
    210                 215                 220                 


Ala Phe Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu 
225                 230                 235                 240 


Leu Arg Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val 
                245                 250                 255     


Ser Ser Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys 
            260                 265                 270         


Leu Gln Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu 
        275                 280                 285             


Arg Gln Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly 
    290                 295                 300                 


Val Phe Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr 
305                 310                 315                 320 


Thr Thr Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met 
                325                 330                 335     


Ile Asn Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile 
            340                 345                 350         


Val Glu Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr 
        355                 360                 365             


Met Asn Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu 
    370                 375                 380                 


Asn Glu Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu 
385                 390                 395                 400 


Lys Gly Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp 
                405                 410                 415     


Val Asn Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu 
            420                 425                 430         


Ile Leu Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala 
        435                 440                 445             


Ala Gly Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr 
    450                 455                 460                 


Glu Gln Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu 
465                 470                 475                 480 


Asn Ser Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile 
                485                 490                 495     


Asp Ser Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr 
            500                 505                 510         


Asn Asp Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly 
        515                 520                 525             


Asn Asn Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu 
    530                 535                 540                 


Ile Gly Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile 
545                 550                 555                 560 


Leu Thr Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys 
                565                 570                 575     


Val Val Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr 
            580                 585                 590         


Gln Leu Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser 
        595                 600                 605             


Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala 
    610                 615                 620                 


Thr Ala Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val 
625                 630                 635                 640 


Lys Met Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met 
                645                 650                 655     


Ser Glu Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val 
            660                 665                 670         


Asn Leu Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr 
        675                 680                 685             


Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg 
    690                 695                 700                 


Asp Ser Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu 
705                 710                 715                 720 


Tyr Lys Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr 
                725                 730                 735     


Asn Glu Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr 
            740                 745                 750         


Lys Ala Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg 
        755                 760                 765             


Asp Val Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu 
    770                 775                 780                 


Glu Asp Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe 
785                 790                 795                 800 


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile 
                805                 810                 815     


Leu Leu Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala 
            820                 825                 830         


Arg Asp Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg 
        835                 840                 845             


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr 
    850                 855                 860                 


Thr Phe Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu 
865                 870                 875                 880 


Phe Ser Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys 
                885                 890                 895     


Phe Tyr Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His 
            900                 905                 910         


Ala Pro Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp 
        915                 920                 925             


Pro Leu Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys 
    930                 935                 940                 


Gln Ile Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys 
945                 950                 955                 960 


Ser Pro Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn 
                965                 970                 975     


Ser Val Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp 
            980                 985                 990         


Asp Val 
        


<210>  21
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IL-15 

<400>  21
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggcagcagc aacaagggtg       60

cactccagaa tctctaagcc ccacctgagg tctatcagca tccagtgcta cctgtgcctg      120

ctgctgaact cccactttct gaccgaggcc ggcatccacg tgttcatcct gggctgcttt      180

tctgccggcc tgcccaagac agaggccaac tgggtgaatg tgatcagcga cctgaagaag      240

atcgaggatc tgatccagtc catgcacatc gacgccaccc tgtatacaga gtctgatgtg      300

caccctagct gcaaggtgac cgccatgaag tgtttcctgc tggagctgca ggtcatcagc      360

ctggagtccg gcgacgcaag catccacgat accgtggaga atctgatcat cctggccaac      420

aattccctga gctccaacgg caatgtgaca gagtctggct gcaaggagtg tgaggagctg      480

gaggagaaga acatcaagga gttcctgcag tcttttgtgc acatcgtgca gatgtttatc      540

aatacaagct gataactcga g                                                561


<210>  22
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-15 

<400>  22

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys 
            20                  25                  30          


Tyr Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile 
        35                  40                  45              


His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu 
    50                  55                  60                  


Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
65                  70                  75                  80  


Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                85                  90                  95      


His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
            100                 105                 110         


Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
        115                 120                 125             


Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
    130                 135                 140                 


Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
145                 150                 155                 160 


Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                165                 170                 175     


Asn Thr Ser 
            


