                         SEQUENCE LISTING

<110>  Salubris Biotherapeutics, Inc.
       Genekey Biotech (Chengdu) Co., Ltd.
 
<120>  HUMAN NEUREGULIN-1 (NRG-1) RECOMBINANT FUSION PROTEIN 
       COMPOSITIONS AND METHODS OF USE THEREOF

<130>  SBTI-001/001WO 332030-2002

<150>  62/656,246
<151>  2018-04-11

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Phe 
                325                 330     


<210>  2
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Glu Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Lys Trp Thr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ala Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Ala His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  3
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Ile Glu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Ser Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Asn Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  4
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  5
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Glycine-Serine linker

<400>  5

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  6
<211>  1614
<212>  DNA
<213>  Homo sapiens

<400>  6
atggagtttg ggctgagctg ggttttcctt gttgctataa taaaaggtgt ccagtgtcag       60

gtgcagctgc agcagtgggg agctggactg ctgaagccaa gcgagaccct gtctctgaca      120

tgcgccgtgt acggaggatc cttcagcgga tactattggt cttggatcag gcagccacct      180

ggcaagggac tggagtggat cggcgagatc aaccactctg gctccaccaa ctacaatccc      240

tctctgaagt cccgggtgac catctccgtg gagacaagca agaatcagtt ttccctgaag      300

ctgtccagcg tgaccgccgc tgacacagcc gtgtactatt gcgctaggga caagtggacc      360

tggtatttcg atctgtgggg aaggggcacc ctggtgacag tgtcttccgc ctctacaaag      420

ggcccctccg tgtttcctct ggctccaagc tctaagagca cctctggagg aacagccgct      480

ctgggatgtc tggtgaagga ttacttccct gagccagtga ccgtgagctg gaactctggc      540

gccctgacct ccggagtgca tacatttccc gctgtgctgc agtccagcgg cctgtatagc      600

ctgtcttccg tggtgaccgt gcctagctct tccctgggca cccagacata catctgcaac      660

gtgaatcaca agccctccaa tacaaaggtg gacaagagag tggagcctaa gagctgtgat      720

aagacccata catgcccacc atgtccagct cctgagctgc tgggaggacc ttccgtgttc      780

ctgtttcctc caaagccaaa ggacaccctg atgatctctc gcacccctga ggtgacatgc      840

gtggtggtgg acgtgtccca cgaggatcca gaggtgaagt tcaactggta cgtggatggc      900

gtggaggtgc ataatgctaa gaccaagcct agggaggagc agtacaacag cacctatcgg      960

gtggtgtctg tgctgacagt gctgcaccag gactggctga acggcaagga gtacaagtgc     1020

aaggtgagca ataaggccct gccagctccc atcgagaaga ccatctctaa ggccaagggc     1080

cagcccagag agcctcaggt gtatacactg ccccctagcc gcgaggagat gaccaagaac     1140

caggtgtctc tgacatgtct ggtgaagggc ttctacccat ctgacatcgc tgtggagtgg     1200

gagtccaatg gccagcccga gaacaattat aagaccacac cacccgtgct ggactccgat     1260

ggcagcttct ttctgtactc caagctgacc gtggataaga gcaggtggca gcagggcaac     1320

gtgttttcct gcagcgtgat gcacgaggcc ctgcacaatc attatacaca gaaatctctg     1380

tccctgagcc caggcaaggg aggaggagga agcggaggag gaggcagctc tcatctggtg     1440

aagtgtgctg agaaggagaa gaccttctgc gtgaacggcg gcgagtgttt tatggtgaag     1500

gacctgtcta atccatccag atacctgtgc aagtgtccca acgagttcac aggcgatcgc     1560

tgccagaatt acgtgatggc ctctttttat aaggctgagg agctgtacca gtaa           1614


<210>  7
<211>  1614
<212>  DNA
<213>  Homo sapiens

<400>  7
atggagtttg ggctgagctg ggttttcctt gttgctataa taaaaggtgt ccagtgtcag       60

gtgcagctgc agcagtgggg agctggactg ctgaagccaa gcgagaccct gtctctgaca      120

tgcgccgtgt acggaggatc cttcagcgga tactattggt cttggatcag gcagccacct      180

ggcaagggac tggagtggat cggcgagatc aaccactctg gctccaccaa ctacaatccc      240

tctctgaagt cccgggtgac catctccgtg gagacaagca agaatcagtt ttccctgaag      300

ctgtccagcg tgaccgccgc tgacacagcc gtgtactatt gcgctaggga caagtggacc      360

tggtatttcg atctgtgggg aaggggcacc ctggtgacag tgtcttccgc ctctacaaag      420

ggcccctccg tgtttcctct ggctccaagc tctaagagca cctctggagg aacagccgct      480

ctgggatgtc tggtgaagga ttacttccct gagccagtga ccgtgagctg gaactctggc      540

gccctgacct ctggagtgca tacatttccc gctgtgctgc agtccagcgg cctgtatagc      600

ctgtcttccg tggtgaccgt gcctagctct tccctgggca cccagacata catctgcaac      660

gtgaatcaca agccctccaa tacaaaggtg gacaagagag tggagcctaa gagctgtgat      720

aagacccata catgcccacc atgtccagct cctgagttcc tgggaggacc tgccgtgttc      780

ctgtttcctc caaagccaaa ggacaccctg atgatctctc gcacccctga ggtgacatgc      840

gtggtggtgg acgtgtccca cgaggatcca gaggtgaagt tcaactggta cgtggatggc      900

gtggaggtgc ataatgctaa gaccaagcct agggaggagc agtacaacag cacctatcgg      960

gtggtgtctg tgctgacagt gctgcaccag gactggctga acggcaagga gtacaagtgc     1020

aaggtgagca ataaggccct gccagctccc atcgagaaga ccatctctaa ggccaagggc     1080

cagcccagag agcctcaggt gtatacactg ccccctagcc gcgaggagat gaccaagaac     1140

caggtgtctc tgacctgtct ggtgaagggc ttctacccat ctgacatcgc tgtggagtgg     1200

gagtccaatg gccagcccga gaacaattat aagaccacac cacccgtgct ggactccgat     1260

ggcagcttct ttctgtactc caagctgacc gtggataaga gcaggtggca gcagggcaac     1320

gtgttttcct gcagcgtgat gcacgaggcc ctgcacgctc attatacaca gaaatctctg     1380

tccctgagcc caggcaaggg aggaggagga agcggaggag gaggcagctc tcatctggtg     1440

aagtgtgctg agaaggagaa gaccttctgc gtgaacggcg gcgagtgttt tatggtgaag     1500

gacctgtcta atccatccag atacctgtgc aagtgtccca acgagttcac aggcgatcgc     1560

tgccagaatt acgtgatggc ctctttttat aaggctgagg agctgtacca gtaa           1614


<210>  8
<211>  723
<212>  DNA
<213>  Homo sapiens

<400>  8
atggtgttgc agacccaggt cttcatttct ctgttgctct ggatctctgg tgcctacggg       60

gacatcgaga tgacccagtc tccagattcc ctggccgtga gcctgggaga gagggctaca      120

atcaactgcc ggtccagcca gtctgtgctg tactcttcca gcaacaggaa ttacctggcc      180

tggtatcagc agaatcccgg ccagccccct aagctgctga tctattgggc tagcaccaga      240

gagtctggag tgcctgaccg cttctctgga tccggaagcg gcacagactt caccctgaca      300

atctcttccc tgcaggccga ggacgtggcc gtgtactatt gccagcagta ttactctacc      360

cctaggacat tcggccaggg caccaaggtg gagatcaagc ggacagtggc cgctccatcc      420

gtgttcatct ttccaccctc cgacgagcag ctgaagtccg gaaccgctag cgtggtgtgc      480

ctgctgaaca acttctaccc aagagaggcc aaggtgcagt ggaaggtgga taacgctctg      540

cagagcggca attctcagga gtccgtgacc gagcaggaca gcaaggattc tacatattcc      600

ctgagctcta ccctgacact gtccaaggcc gattacgaga agcacaaggt gtatgcttgc      660

gaggtgaccc atcagggcct gtccagcccc gtgacaaaga gcttcaaccg cggcgagtgt      720

taa                                                                    723


<210>  9
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe 
        35                  40                  45              


Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Glu Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Lys Trp Thr Trp Tyr Phe Asp Leu Trp Gly Arg 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser His Leu Val 
465                 470                 475                 480 


Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys 
                485                 490                 495     


Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys 
            500                 505                 510         


Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser 
        515                 520                 525             


Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    530                 535         


<210>  10
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe 
        35                  40                  45              


Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Glu Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Lys Trp Thr Trp Tyr Phe Asp Leu Trp Gly Arg 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
                245                 250                 255     


Pro Ala Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser His Leu Val 
465                 470                 475                 480 


Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys 
                485                 490                 495     


Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys 
            500                 505                 510         


Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser 
        515                 520                 525             


Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    530                 535         


<210>  11
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  12
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Glu Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Ser Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Asn Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Arg Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  13
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly 
            20  


<210>  14
<211>  518
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain component of the recombinant fusion protein

<400>  14

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Glu Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Lys Trp Thr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ala Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Ala His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser His Leu Val Lys Cys Ala 
    450                 455                 460                 


Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val 
465                 470                 475                 480 


Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu 
                485                 490                 495     


Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys 
            500                 505                 510         


Ala Glu Glu Leu Tyr Gln 
        515             


<210>  15
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  15

His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr Cys Val Asn Gly 
1               5                   10                  15      


Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu Ser Cys Lys Cys 
            20                  25                  30          


Pro Asn Gly Phe Phe Gly Gln Arg Cys Leu 
        35                  40          


<210>  16
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  16

His Phe Lys Pro Cys Arg Asp Lys Asp Leu Ala Tyr Cys Leu Asn Asp 
1               5                   10                  15      


Gly Glu Cys Phe Val Ile Glu Thr Leu Thr Gly Ser His Lys His Cys 
            20                  25                  30          


Arg Cys Lys Glu Gly Tyr Gln Gly Val Arg Cys Asp 
        35                  40                  


<210>  17
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  17

His Glu Glu Pro Cys Gly Pro Ser His Lys Ser Phe Cys Leu Asn Gly 
1               5                   10                  15      


Gly Leu Cys Tyr Val Ile Pro Thr Ile Pro Ser Pro Phe Cys Arg Cys 
            20                  25                  30          


Val Glu Asn Tyr Thr Gly Ala Arg Cys Glu 
        35                  40          


<210>  18
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGF like domain consensus sequence

<400>  18

Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Glu Cys Phe Met Val 
1               5                   10                  15      


Lys Asp Leu Ser Asn Pro 
            20          


