                               SEQUENCE LISTING

<110> CHAN ZUCKERBERG BIOHUB, INC.
      THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
 
<120> COMPOSITIONS AND METHODS FOR MODULATING LEFT-RIGHT 
      DIFFERENTIATION FACTOR (LEFTY) AND BONE MORPHOGENIC FACTOR (BMP)

<130> 103182-1132920-000510WO

<140> PCT/US2019/027523
<141> 2019-04-15

<150> 62/667,128
<151> 2018-05-04

<150> 62/657,587
<151> 2018-04-13

<160> 15    

<170> PatentIn version 3.5

<210> 1
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
ccggagccca atgtgtcatt gtttactcga gtaaacaatg acacattggg cttttttg         58


<210> 2
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
ccggtctcta gtgagccctg aatttctcga gaaattcagg gctcactaga gatttttg         58


<210> 3
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
ccggacaagt tacctcacct aatttctcga gaaattaggt gaggtaactt gttttttg         58


<210> 4
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
ccggtgaact gctgatggac aaatgctcga gcatttgtcc atcagcagtt catttttg         58


<210> 5
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
cagaattcgc gggccgcacc atgccattcc tgtggctctg                             40


<210> 6
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
cttctagact atggctgcag cctcctgg                                          28


<210> 7
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
tggacaaggc tgatgtggaa ttcaagagat tccacatcag ccttgtcctt ttttc            55


<210> 8
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
tcgagaaaaa aggacaaggc tgatgtggaa tctcttgaat tccacatcag ccttgtcca        59


<210> 9
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
tgcaggttcc tggtgtcaga ttcaagagat ctgacaccag gaacctgctt ttttc            55


<210> 10
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
tcgagaaaaa agcaggttcc tggtgtcaga tctcttgaat ctgacaccag gaacctgca        59


<210> 11
<211> 366
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Gln Pro Leu Trp Leu Cys Trp Ala Leu Trp Val Leu Pro Leu Ala 
1               5                   10                  15      


Ser Pro Gly Ala Ala Leu Ala Gly Glu Gln Leu Leu Gly Ser Leu Leu 
            20                  25                  30          


Arg Gln Leu Gln Leu Lys Glu Val Pro Thr Leu Asp Arg Ala Asp Met 
        35                  40                  45              


Glu Glu Leu Val Ile Pro Thr His Val Arg Ala Gln Tyr Val Ala Leu 
    50                  55                  60                  


Leu Gln Arg Ser His Gly Asp Arg Ser Arg Gly Lys Arg Phe Ser Gln 
65                  70                  75                  80  


Ser Phe Arg Glu Val Ala Gly Arg Phe Leu Ala Leu Glu Ala Ser Thr 
                85                  90                  95      


His Leu Leu Val Phe Gly Met Glu Gln Arg Leu Pro Pro Asn Ser Glu 
            100                 105                 110         


Leu Val Gln Ala Val Leu Arg Leu Phe Gln Glu Pro Val Pro Lys Ala 
        115                 120                 125             


Ala Leu His Arg His Gly Arg Leu Ser Leu Arg Ser Ala Arg Ala Arg 
    130                 135                 140                 


Val Thr Val Glu Trp Leu Arg Val Arg Asp Asp Gly Ser Asn Arg Thr 
145                 150                 155                 160 


Ser Leu Ile Asp Ser Arg Leu Val Ser Val His Glu Ser Gly Trp Lys 
                165                 170                 175     


Ala Phe Asp Val Thr Glu Ala Val Asn Phe Trp Gln Gln Leu Ser Arg 
            180                 185                 190         


Pro Arg Gln Pro Leu Leu Leu Gln Val Ser Val Gln Arg Glu His Leu 
        195                 200                 205             


Gly Pro Leu Ala Ser Gly Ala His Lys Leu Val Arg Phe Ala Ser Gln 
    210                 215                 220                 


Gly Ala Pro Ala Gly Leu Gly Glu Pro Gln Leu Glu Leu His Thr Leu 
225                 230                 235                 240 


Asp Leu Gly Asp Tyr Gly Ala Gln Gly Asp Cys Asp Pro Glu Ala Pro 
                245                 250                 255     


Met Thr Glu Gly Thr Arg Cys Cys Arg Gln Glu Met Tyr Ile Asp Leu 
            260                 265                 270         


Gln Gly Met Lys Trp Ala Glu Asn Trp Val Leu Glu Pro Pro Gly Phe 
        275                 280                 285             


Leu Ala Tyr Glu Cys Val Gly Thr Cys Arg Gln Pro Pro Glu Ala Leu 
    290                 295                 300                 


Ala Phe Lys Trp Pro Phe Leu Gly Pro Arg Gln Cys Ile Ala Ser Glu 
305                 310                 315                 320 


Thr Asp Ser Leu Pro Met Ile Val Ser Ile Lys Glu Gly Gly Arg Thr 
                325                 330                 335     


Arg Pro Gln Val Val Ser Leu Pro Asn Met Arg Val Gln Lys Cys Ser 
            340                 345                 350         


Cys Ala Ser Asp Gly Ala Leu Val Pro Arg Arg Leu Gln Pro 
        355                 360                 365     


<210> 12
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
cgaactgctg atggacaaa                                                    19


<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Gly Gly Gly Ser 
1               5   


<210> 14
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
ggacaaggct gatgtggaa                                                    19


<210> 15
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
gcaggttcct ggtgtcaga                                                    19


