                         SEQUENCE LISTING

<110>  Universidade de Santiago de Compostela
 
<120>  Cell penetrating peptides

<130>  P191842WO

<150>  EP18382216.8
<151>  2018-04-18

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-carboxytetramethyl rhodamine (TAMRA) in position 1 (Ala)

<400>  1

Ala Arg Ala Ala Ala Ala Ala Ala Arg Ala Ala Ala Ala Ala Ala Arg 
1               5                   10                  15      


<210>  2
<211>  16
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  55-carboxytetramethyl rhodamine (TAMRA) in position 1 (Ala)

<400>  2

Ala Arg Ala Leu Ala Ala Leu Ala Arg Ala Ala Ala Ala Ala Ala Arg 
1               5                   10                  15      


<210>  3
<211>  16
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-carboxytetramethyl rhodamine (TAMRA) in position 1 (Ala) 
       through aminohexanoic acid (-(C=O)-(CH2)5-N(H)-)

<400>  3

Ala Arg Ala Ala Leu Leu Ala Ala Arg Ala Ala Leu Ala Ala Ala Arg 
1               5                   10                  15      


<210>  4
<211>  16
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-carboxytetramethyl rhodamine (TAMRA) in position 1 (Leu)

<400>  4

Leu Arg Ala Leu Arg Arg Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-carboxytetramethyl rhodamine (TAMRA) in position 1 (Leu) 
       through aminohexanoic acid (-(C=O)-(CH2)5-N(H)-)

<400>  5

Leu Arg Ala Ala Ala Ala Ala Leu Arg Ala Ala Ala Ala Ala Leu Arg 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-carboxytetramethyl rhodamine (TAMRA) in position 1 (Ala) 
       through aminohexanoic acid (-(C=O)-(CH2)5-N(H)-)

<400>  6

Ala Arg Ala Leu Ala Ala Leu Ala Arg Ala Leu Ala Ala Ala Ala Arg 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-carboxytetramethyl rhodamine (TAMRA) in position 1 (Ala)

<400>  7

Ala Arg Ala Leu Ala Ala Leu Ala Arg Ala Leu Ala Ala Ala Ala Arg 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-carboxytetramethyl rhodamine (TAMRA) in position 1 (Leu)

<400>  8

Leu Arg Ala Leu Ala Ala Leu Ala Arg Ala Ala Ala Ala Ala Ala Arg 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  9

Leu Arg Ala Leu Ala Ala Leu Ala Arg Ala Ala Ala Ala Ala Ala Arg 
1               5                   10                  15      


<210>  10
<211>  13
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION in position 1 (Arg)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  (-(C=O)-(CH2)-O-N=(CH)-(CH2)-alpha-D-Mannose) in position 2 (Lys)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  (-(C=O)-(CH2)-O-N=(CH)-(CH2)-alpha-D-Mannose) in position 11 
       (Lys)

<400>  10

Arg Lys Leu Arg Arg Leu Leu Arg Arg Leu Lys Arg Leu 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-carboxytetramethyl rhodamine (TAMRA) in position 1 (Arg)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  (-(C=O)-(CH2)-O-N=(CH)-(CH2)-alpha-D-Mannose) in position 2 (Lys)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  (-(C=O)-(CH2)-O-N=(CH)-(CH2)-alpha-D-Mannose) in position 11 
       (Lys)

<400>  11

Arg Lys Leu Arg Arg Leu Leu Arg Arg Leu Lys Arg Leu 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

ACETYLATION in position 1 (Arg)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  -C(=O)-O-(CH)2-(CH)=(CH2) in position 2  (Lys)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  (-(C=O)-(CH2)-O-N=(CH)-(CH2)-alpha-D-Mannose) in position 11 
       (Lys)

<400>  12

Arg Lys Leu Arg Arg Leu Leu Arg Arg Leu Lys Arg Leu 
1               5                   10              


<210>  13
<211>  13
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-carboxytetramethyl rhodamine (TAMRA) in position 1 (Arg)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  -C(=O)-O-(CH)2-(CH)=(CH2) in position 2 (Lys)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  (-(C=O)-(CH2)-O-N=(CH)-(CH2)-alpha-D-Mannose) in position 11 
       (Lys)

<400>  13

Arg Lys Leu Arg Arg Leu Leu Arg Arg Leu Lys Arg Leu 
1               5                   10              


<210>  14
<211>  13
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

in position 1 (Arg)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  (-(C=O)-(CH2)4-biotin) in position 2 (Lys)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  (-(C=O)-(CH2)4-biotin) in position 11 (Lys)

<400>  14

Arg Lys Leu Arg Arg Leu Leu Arg Arg Leu Lys Arg Leu 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Dextamethasone acid in position 1 (Arg)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  (-(C=O)-(CH2)-O-N=(CH)-(CH2)-alpha-D-Mannose) in position 2 (Lys)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  (-(C=O)-(CH2)-O-N=(CH)-(CH2)-alpha-D-Mannose) in position 11 
       (Lys)

<400>  15

Arg Lys Leu Arg Arg Leu Leu Arg Arg Leu Lys Arg Leu 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-carboxytetramethyl rhodamine (TAMRA) in position 1 (Arg)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  (-(C=O)-(CH2)-O-N=(CH)-(CH2)-Glucose) in position 2 (Lys)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  (-(C=O)-(CH2)-O-N=(CH)-(CH2)-Glucose) in position 11 (Lys)

<400>  16

Arg Lys Leu Arg Arg Leu Leu Arg Arg Leu Lys Arg Leu 
1               5                   10              


<210>  17
<211>  13
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

ACETYLATION in position 1 (Arg)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  (-(C=O)-(CH2)-O-NH2) in position 2 (Lys)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  (-(C=O)-(CH2)-O-NH2) in position 11 (Lys)

<400>  17

Arg Lys Leu Arg Arg Leu Leu Arg Arg Leu Lys Arg Leu 
1               5                   10              


<210>  18
<211>  13
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-carboxytetramethyl rhodamine (TAMRA) in position 1 (Arg)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  (-(C=O)-(CH2)-O-NH2) in position 2 (Lys)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  (-(C=O)-(CH2)-O-NH2) in position 11 (Lys)

<400>  18

Arg Lys Leu Arg Arg Leu Leu Arg Arg Leu Lys Arg Leu 
1               5                   10              


<210>  19
<211>  13
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Dextamethasone acid in position 1 (Arg)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  (-(C=O)-(CH2)-O-NH2) in position 2 (Lys)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  (-(C=O)-(CH2)-O-NH2) in position 11 (Lys)

<400>  19

Arg Lys Leu Arg Arg Leu Leu Arg Arg Leu Lys Arg Leu 
1               5                   10              


<210>  20
<211>  13
<212>  PRT
<213>  N/A


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-carboxytetramethyl rhodamine (TAMRA) through aminohexanoic acid (-(C=O)-(CH2)5-N(H)-)

in position 1 (Arg)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  -(C=O)-[C1=(CH)-(CR1)=(CH)-(CR2)=CH1], where C1 and CH1 close the 6 carbon cycle with a single bond and R1 = R2 = [NH-(C=O)-(CH2)-O-N=CH-(CH2)-Glucose] 
in position 2 (Lys)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  -(C=O)-[C1=(CH)-(CR1)=(CH)-(CR2)=CH1], where C1 and CH1 close the 6 carbon cycle with a single bond and R1 = R2 = [NH-(C=O)-(CH2)-O-N=CH-(CH2)-Glucose] 
in position 11 (Lys)

<400>  20

Arg Lys Leu Arg Arg Leu Leu Arg Arg Leu Lys Arg Leu 
1               5                   10              


