                         SEQUENCE LISTING

<110>  Biosion Inc.
 
<120>  ANTIBODIES BINDING PD-1 AND USES THEREOF

<130>  55532 00004

<150>  US62/657927
<151>  2018-04-15

<160>  130   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for C1E1, huC1E1-V1 - huC1E1-V7 and huC1E1-V10

<400>  1

Gly Phe Thr Phe Ser Ser Tyr Leu 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for C1E1, huC1E1-V1 - huC1E1-V7 and huC1E1-V10

<400>  2

Ile Ser Gly Gly Gly Gly Asp Thr 
1               5               


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for C1E1, huC1E1-V1 - huC1E1-V7 and huC1E1-V10

<400>  3

Val Arg Phe Gly Gly Ala Gly Tyr Tyr Trp Tyr Phe Asp 
1               5                   10              


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for D1F2

<400>  4

Gly Phe Thr Phe Ser Ser Tyr Thr 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for D1F2

<400>  5

Ile Ser Gly Gly Gly Ser Asn Ile 
1               5               


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for D1F2

<400>  6

Val Leu Asn Tyr Ala Tyr Ala Met Asp Tyr Trp Gly Gln 
1               5                   10              


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for C1F5

<400>  7

Gly Phe Ala Phe Ser Ser Tyr Asp 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for C1F5

<400>  8

Ile Thr Gly Gly Gly Ser Ser Ser 
1               5               


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for C1F5

<400>  9

Ala Ser Pro Tyr Leu Ser Tyr Phe Asp Tyr Trp Gly Gln 
1               5                   10              


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for D1A1

<400>  10

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for D1A1

<400>  11

Ile Ser Gly Gly Gly Gly Asn Ile 
1               5               


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for D1A1

<400>  12

Ala Ser Pro Tyr Ala Asn Tyr Val Trp Tyr Leu Asp Val 
1               5                   10              


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for D1F1

<400>  13

Gly Phe Thr Phe Ser Ser Asn Thr 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for D1F1

<400>  14

Ile Ser Gly Gly Gly Val Asn Thr 
1               5               


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for D1F1

<400>  15

Ala Arg His Gly Asn Tyr Asn Tyr Tyr Gly Met Asp Tyr 
1               5                   10              


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for C1E2

<400>  16

Gly Tyr Thr Phe Thr Asn Tyr Trp 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for C1E2

<400>  17

Ile Tyr Pro Gly Gly Gly Tyr Thr 
1               5               


<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for C1E2

<400>  18

Ala Arg Gly Tyr Gly Thr Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for C1A1

<400>  19

Gly Phe Ser Leu Ser Thr Ser Gly Met Gly 
1               5                   10  


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for C1A1

<400>  20

Ile Trp Trp Asp Asp Asp Lys 
1               5           


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for C1A1

<400>  21

Ala Arg Thr Gly Gly Phe Ile Thr Thr Gly Tyr Trp Tyr 
1               5                   10              


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for C1F4

<400>  22

Gly Tyr Lys Phe Thr Asp Tyr Ala 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for C1F4

<400>  23

Ile Ser Thr Tyr Ser Gly Asp Val 
1               5               


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for C1F4

<400>  24

Ser Arg Leu Gly Ile Thr Ala Gly Phe Ala Tyr Trp Gly 
1               5                   10              


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for D2C2

<400>  25

Gly Phe Thr Phe Ser Ser Asn Thr 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for D2C2

<400>  26

Ile Ser Gly Gly Gly Val Asp Thr 
1               5               


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for D2C2

<400>  27

Ala Arg His Gly Asn Tyr Asn Tyr Tyr Gly Met Asp Tyr 
1               5                   10              


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for 2G2

<400>  28

Gly Phe Thr Phe Ser Tyr Tyr Gly 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for 2G2

<400>  29

Ile Ser Ser Gly Ser Ser Phe Thr 
1               5               


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for 2G2

<400>  30

Thr Arg Arg Glu Gly Ile Tyr Asp Ala Ser Trp Asp Tyr 
1               5                   10              


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for C1C5

<400>  31

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for C1C5

<400>  32

Ile Asn Thr Tyr Ser Gly Glu Pro 
1               5               


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for C1C5

<400>  33

Val Arg Gln Gly Asp Phe Asp Tyr Glu Asp Ala Met Asp 
1               5                   10              


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for C1E1, huC1E1-V1 - huC1E1-V7 and huC1E1-V10

<400>  34

Arg Ala Ser Lys Ser Val Asp Asp Ser Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for C1E1, huC1E1-V1 - huC1E1-V7 and huC1E1-V10

<400>  35

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for C1E1, huC1E1-V1 - huC1E1-V7 and huC1E1-V10

<400>  36

His Gln Thr Lys Glu Val Pro Trp Thr 
1               5                   


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for D1F2

<400>  37

Arg Ala Ser Gln Asp Ile Ser Asn Phe Leu Asn 
1               5                   10      


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for D1F2

<400>  38

Tyr Thr Ser Arg Leu Gln Ser 
1               5           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for D1F2

<400>  39

Gln Gln Gly Ser Ser Leu Pro Trp Thr 
1               5                   


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for C1F5

<400>  40

Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu His 
1               5                   10      


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for C1F5

<400>  41

Gly Ser Gln Ser Met Ser 
1               5       


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for C1F5

<400>  42

Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for D1A1

<400>  43

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for D1A1

<400>  44

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for D1A1

<400>  45

Gln Gln Ser Asn Ala Leu Pro Trp Thr 
1               5                   


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for D1F1

<400>  46

Arg Ala Ser Glu Ser Val Asp Asn Ser Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for D1F1

<400>  47

Thr Ala Ser Asn Gln Gly Ser 
1               5           


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for D1F1

<400>  48

Gln Gln Ser Tyr Glu Val Pro Trp Thr 
1               5                   


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for C1E2

<400>  49

Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for C1E2

<400>  50

Tyr Ala Phe His Arg Tyr Thr 
1               5           


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for C1E2

<400>  51

Gln Gln Asp Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for C1A1

<400>  52

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ile 
1               5                   10      


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for C1A1

<400>  53

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for C1A1

<400>  54

Gln Gln His Lys Thr Leu Pro Trp Thr 
1               5                   


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for C1F4

<400>  55

Lys Ala Ser Gln Asn Val Arg Thr Ala Val Ala 
1               5                   10      


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for C1F4

<400>  56

Leu Ala Ser Asn Arg His Thr 
1               5           


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for C1F4

<400>  57

Leu Gln His Trp Asn Tyr Pro Tyr Thr 
1               5                   


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for D2C2

<400>  58

Arg Ala Ser Glu Ser Val Asp Asn Ser Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for D2C2

<400>  59

Ile Ala Ser Asn His Gly Ser 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for D2C2

<400>  60

Gln Gln Ser Tyr Glu Val Pro Trp Thr 
1               5                   


<210>  61
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for 2G2

<400>  61

Arg Ser Ser Gln Ser Ile Ile Arg Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for 2G2

<400>  62

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for 2G2

<400>  63

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  64
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for C1C5

<400>  64

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly His Ile Tyr Leu Glu 
1               5                   10                  15      


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for C1C5

<400>  65

Lys Val Ser Lys Arg Phe Ser 
1               5           


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for C1C5

<400>  66

Phe Gln Gly Ser His Gly Thr 
1               5           


<210>  67
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for C1E1

<400>  67

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Leu Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Gly Asp Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Phe Gly Gly Ala Gly Tyr Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  68
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for huC1E1-V1, huC1E1-V3 - huC1E1-V7

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Leu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Gly Asp Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Phe Gly Gly Ala Gly Tyr Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  69
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for huC1E1-V2 and huC1E1-V10

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Leu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Gly Asp Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Phe Gly Gly Ala Gly Tyr Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  70
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for D1F2

<400>  70

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Ser Asn Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu His Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Leu Asn Tyr Ala Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  71
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for C1F5

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Gly Gly Gly Ser Ser Ser Phe Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Leu Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  72
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for D1A1

<400>  72

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Gly Asn Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Ala Asn Tyr Val Trp Tyr Leu Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  73
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for D1F1

<400>  73

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Gly Gly Gly Val Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Asn Tyr Asn Tyr Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  74
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for C1E2

<400>  74

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Phe Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Thr Asn Tyr Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  75
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for C1A1

<400>  75

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Phe Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Gln Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Gly Gly Phe Ile Thr Thr Gly Tyr Trp Tyr Phe Asp 
            100                 105                 110         


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  76
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for C1F4

<400>  76

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Lys Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Thr Tyr Ser Gly Asp Val Ser Phe Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Leu Gly Ile Thr Ala Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  77
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for D2C2

<400>  77

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Gly Gly Gly Val Asp Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Asn Tyr Asn Tyr Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  78
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for 2G2

<400>  78

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Ser Ser Phe Thr Tyr Ser Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Glu Gly Ile Tyr Asp Ala Ser Trp Asp Tyr Ser Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  79
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for C1C5

<400>  79

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Glu Pro Thr Tyr Ser Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ser Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Gln Gly Asp Phe Asp Tyr Glu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  80
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for C1E1

<400>  80

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Asp Asp Ser 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys His Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  81
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for huC1E1-V1 and huC1E1-V2

<400>  81

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Asp Asp Ser 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys His Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  82
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for huC1E1-V3

<400>  82

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Asp Asp Ser 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys His Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  83
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for huC1E1-V4

<400>  83

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Asp Asp Ser 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys His Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  84
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for huC1E1-V5

<400>  84

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Asp Asp Ser 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys His Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  85
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for huC1E1-V6

<400>  85

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Asp Asp Ser 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  86
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for huC1E1-V7 and huC1E1-V10

<400>  86

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Asp Asp Ser 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  87
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for D1F2

<400>  87

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Phe Cys Gln Gln Gly Ser Ser Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  88
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for C1F5

<400>  88

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Gly Ser Gln Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Val Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  89
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for D1A1

<400>  89

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Asn Leu Glu Glu 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Ser Asn Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  90
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for D1F1

<400>  90

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Val Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Ser 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Thr Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Ser Ala Met Tyr Phe Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  91
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for C1E2

<400>  91

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Phe His Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  92
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for C1A1

<400>  92

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ile Trp Tyr Gln Gln Lys Thr Asp Gly Thr Leu Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln His Lys Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  93
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for C1F4

<400>  93

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Lys Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  94
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for D2C2

<400>  94

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Ser 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ile Ala Ser Asn His Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Ser Ala Met Tyr Phe Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  95
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for 2G2

<400>  95

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Ile Arg Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Leu Gly Leu Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  96
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for C1C5

<400>  96

Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly His Ile Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Gly Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 


<210>  97
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG1 heavy chain constant region

<400>  97

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  98
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human kappa light chain constant region

<400>  98

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  99
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG1 heavy chain CH1 region

<400>  99

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val 
        


<210>  100
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  100

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu 
            100                 105                 110         


Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro 
        115                 120                 125             


Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln Glu 
    130                 135                 140                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        195                 200                 205             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    210                 215                 220                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                245                 250                 255     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            260                 265                 270         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        275                 280                 285             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    290                 295                 300                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
305                 310                 315                 320 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                325                 330                 335     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            340                 345                 350         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        355                 360                 365             


Leu Ser Leu 
    370     


<210>  101
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  101

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  102
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for C1E1

<400>  102
gaagtgatgc tggtggagtc tgggggaggg ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cacgttcagt agttatctta tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtggtg gtggtggtga cacctacttt      180

ccagacagtg tgaagggtcg attcaccatc tccagagaca atgtcaagaa caacctgtac      240

ctgcaaatga gcagtcttag gtctgaggac acggccttgt attactgtgt aagatttggg      300

ggcgctggtt actactggta tttcgatgtc tggggcgcag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  103
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for huC1E1-V2 and huC1E1-V10

<400>  103
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatctta tgtcctgggt ccgccaggct      120

ccaggcaagg ggctagagtg ggtggcaact atatcaggtg gtggaggtga cacatacttc      180

ccagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgt gagattcggt      300

ggtgctggtt actactggta ctttgacgtc tggggccaag gaaccctggt caccgtctcg      360

agt                                                                    363


<210>  104
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for D1F2

<400>  104
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatacca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtggtg gtggtagtaa catctactat      180

ccagacagtg tggagggtcg attcaccgtc tccagagaca atgccaggaa caccctgtac      240

ctgcatatga gcagtctgag gtctgaggac acggccttat attactgtgt ccttaactac      300

gcctatgcta tggactactg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  105
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for C1F5

<400>  105
gaagtgcagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cgctttcagt agctatgaca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcatac attactggtg gtggtagtag ttccttctat      180

ccagacactg tgaagggccg attcaccatc tccagagaca attccaagaa caccctgtat      240

ttgcaaatga ccagtctgag gtctgaggac acagccatgt attactgtgc aagcccctac      300

ttatcctact ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  106
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for D1A1

<400>  106
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt aactatgcca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtggtg gtggtggtaa catctactat      180

ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaggaa caccctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccttgt attattgtgc aagcccgtat      300

gctaactacg tatggtacct cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360


<210>  107
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for D1F1

<400>  107
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agcaatacca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcagcc attagtggtg gtggtgttaa cacctactat      180

ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaggaa caccctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccctgt attactgtgc aagacatggt      300

aactacaatt actatggtat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  108
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for C1E2

<400>  108
caggtccagt tgcagcagtc tggagctgag ctggtaaggc ctgggacttc agtgaagata       60

tcctgcaagg cttctggcta caccttcact aactactggc taggttgggt aaaacagagg      120

cctggacatg gacttgagtg gattggagat atttaccctg gaggtggtta tactaactac      180

aatgagaact tcaagggcaa ggccacactg actgcagaca catcctccag cactgcctac      240

atgcagctca gtagcctgac atctgaggac tctgctgtct ttttctgtgc aagaggctac      300

ggtactaatt actggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360


<210>  109
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for C1A1

<400>  109
caagttactc taaaagagtc tggccctggg atattgaagc cctcacagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctggta tgggtgtagg ctggattcgt      120

cagccttcag ggaagggtct ggagtggctg gcacacattt ggtgggatga tgataagttc      180

tataacccat ccctgaagag ccagctcaca atctccaagg atacctccag aaaccaggtt      240

ttcctcaaga tcaccagtgt ggacactgca gatactgcca cttactactg tgctcgaacc      300

ggggggttta ttactacggg ctactggtac ttcgatgtct ggggcgcagg gaccacggtc      360

accgtctcct ca                                                          372


<210>  110
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for C1F4

<400>  110
caggtccagc tgcaacagtc tggggctgag ctggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttctggcta caaattcact gattatgcta tgcactgggt gaggcagagt      120

catgcaaaga gtctagagtg gattggaatt attagtactt actctggtga cgttagtttc      180

aaccagaact tcaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagactgac atctgaggat tctgccatct attactgttc aagactgggg      300

attacggcgg ggtttgctta ctggggccaa gggactctgg tcactgtctc tgca            354


<210>  111
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for D2C2

<400>  111
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agcaatacca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcagcc attagtggtg gtggtgttga cacctactat      180

ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaggaa caccctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccctgt attactgtgc aagacatggt      300

aactacaatt actatggtat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  112
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for 2G2

<400>  112
gaggtgcaac tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtacag cctctggatt cactttcagt tactatggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggaatg ggtcgcaacc attagtagtg gtagtagttt cacctactct      180

ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctacaaatga acagtctgaa gtctgaggac acagccattt attactgtac aagacgagag      300

gggatctatg atgcttcctg ggattattct atggactact ggggtcaagg aacctcagtc      360

accgtctcct ca                                                          372


<210>  113
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for C1C5

<400>  113
cagatccagt tggtgcagtc aggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa taaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct atagtggaga gccaacatat      180

tctgatgact tcaagggacg ctttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acgtctacat atttctgtgt aagacagggg      300

gactttgatt acgaggatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  114
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for C1E1

<400>  114
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcaa aagtgttgat gattctggca ttagttttat gcactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc      180

ggggtccctg ccaggtttcg tggcagtggg tctgggacag acttcagcct caacatccat      240

cctatggagg aggatgatac tgcaatgtat ttctgtcacc aaactaagga ggttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  115
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for huC1E1-V7 and huC1E1-V10

<400>  115
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtaa gtctgttgac gacagtggta tcagcttcat gcactggtat      120

caacagaaac ctggccaggc tcccaggctc ctcatctatg ctgcatccaa ccagggctct      180

ggcatcccag ccaggttcag tggcagtggg tctgggacag acttcactct caccatcagc      240

agcctagagc ctgaagattt tgcagtttat tactgtcatc agactaagga ggtgccttgg      300

acgttcggcc aagggaccaa ggtggagatc aaa                                   333


<210>  116
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for D1F2

<400>  116
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggccagtca ggacattagc aattttttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac acatcaagat tacagtcagg agtcccatca      180

aggttcagtg gcactgggtc tgggacagat tattctctca ccattagcaa cctggaacaa      240

gaagatcttg ccacttactt ttgccaacag ggtagttcgc ttccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  117
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for C1F5

<400>  117
gatattgtgc taactcagtc tccagccacc ctgtctgtga ctccaggaga tagcgtcagt       60

ctttcctgca gggccagcca aagtattagc aacaacctac actggtatca acaaaaatca      120

catgagtctc caaggcttct catcaagtat ggttcccagt ccatgtctgg gatcccctcc      180

aggttcagtg gcagtggatc agggacagat ttcactctcg ttatcaacag tgtggagact      240

gaagattttg gaatgtattt ctgtcaacag agtaacagct ggcctctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  118
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for D1A1

<400>  118
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat ttttctctca ccattagcaa cctggaagaa      240

gaagatattg ccacttactt ttgccaacag agtaatgcgc ttccgtggac gttcggtgga      300

ggcaccaaac tggaaatcaa a                                                321


<210>  119
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for D1F1

<400>  119
gacattgtgc tgacccaatc tccagcttct ttggttgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattctggca ttagttttat gaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctata ctgcatccaa ccaaggatcc      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctatggagg aggatgattc tgcaatgtat ttctgtcagc aaagttatga ggttccttgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  120
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for C1E2

<400>  120
agtattgtga tgacccagac tcccaaattc ctgcttgtat cagcaggaga cagggttacc       60

ataacctgca aggccagtca gagtgtgagt aatgatgtag cttggtacca acagaagcca      120

gggcagtctc ctaaactgct gatatactat gcatttcatc gctacactgg agtccctgat      180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcagcac tgtgcaggct      240

gaagacctgg cagtttattt ctgtcagcag gattatagct ctccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  121
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for C1A1

<400>  121
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagc aattatttaa tctggtatca gcagaaaaca      120

gatggaactc ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccagcag cataaaacgc ttccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  122
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for C1F4

<400>  122
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcacc       60

atcacctgca aggccagtca gaatgttcgt actgctgtag cctggtatca acagaaacca      120

gggcagtctc ctaaagcact gatttacttg gcatccaacc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcaatct      240

aaagacctgg cagattattt ctgtctgcaa cattggaatt atccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  123
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for D2C2

<400>  123
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattctggca ttagttttat gaactggttc      120

caacagaaac caggacagtc acccaaactc ctcatctata ttgcatccaa ccacggatcc      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctatggagg aggatgattc tgcaatgtat ttctgtcagc aaagttatga ggttccttgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  124
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for 2G2

<400>  124
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattata cgtagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgacga tctgggactt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  125
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for C1C5

<400>  125
gatgttttga tgacccaaag tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagtattgta catagtaatg gacacatcta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caagcgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgggacg      300

ttcggtggag gcaccaagct ggaaatcaaa                                       330


<210>  126
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IgG1 heavy chain constant region

<400>  126
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  127
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human kappa light chain constant region

<400>  127
cgtacggtgg cggcgccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  128
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IgG1 heavy chain CH1 region

<400>  128
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agtt            294


<210>  129
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain constant region for mouse antibodies

<400>  129

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210>  130
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain constant region for mouse antibodies

<400>  130

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


