                         SEQUENCE LISTING

<110>  Casebia Therapeutics Limited Liability Partnership
       Brooks, Alan R.
       Vo, Karen
       Scharenberg, Andrew M.
 
<120>  Compositions and Methods for Knockdown of APO(A) by Gene Editing 
       for Treatment of Cardiovascular Disease

<130>  052984-519001WO

<140>  PCT/US2019/028210
<141>  2019-04-18

<150>  US 62/659,631
<151>  2018-04-18

<160>  165   

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  5'UTR Exon 2 Junction

<400>  1
catgtaagtc aacaatgtcc                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  5'UTR Exon 2 Junction

<400>  2
atgtaagtca acaatgtcct                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  5'UTR Exon 2 Junction

<400>  3
agtcaacaat gtcctgggat                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  5'UTR Exon 2 Junction

<400>  4
gtcaacaatg tcctgggatt                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 2 T6160

<400>  5
agaaagtgtg tcccaatccc                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 2 T4151

<400>  6
tgggattggg acacactttc                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 2 T14695

<400>  7
acacactttc tgggcactgc                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 2 T13689

<400>  8
cttatgttcc attttgggac                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 2 T5776

<400>  9
cagtcccaaa atggaacata                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 2 T10461

<400>  10
acttccttat gttccatttt                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 2 T10960

<400>  11
caaaatggaa cataaggaag                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 2 T15100

<400>  12
cttcttttat ttctgaaatc                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 3  T14467

<400>  13
agcacctgag caaagccatg                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 3  T1  T5513

<400>  14
tggaccacat ggctttgctc                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 3  T2  T13789

<400>  15
tgagcaaagc catgtggtcc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 3  T10762

<400>  16
gtggtcctat tatgttgatg                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 3

<400>  17
cgcatttggg tagttttctg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 3  T4  T2982

<400>  18
gattaatgac atacgcattt                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 3  T5  T1530

<400>  19
agattaatga catacgcatt                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T693

<400>  20
attgtggatg acgactgacc                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T1826

<400>  21
cagtcgtcat ccacaatcaa                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T1413

<400>  22
caggatcagt ccattgattg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T858

<400>  23
caatggactg atcctgccgc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T1233

<400>  24
agcagggtaa gtccagcggc                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T11260

<400>  25
gggcagcagg gtaagtccag                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T11763

<400>  26
gccctccctg atggggcctt                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T7918

<400>  27
ttcaatcctc ttgtcacctg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T6334

<400>  28
ggtaggccac aggtgacaag                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T14744

<400>  29
tgtcatctct gagggcaggt                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T13973

<400>  30
catagagatg tcatctctga                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T4496

<400>  31
cagagatgac atctctatgt                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T221

<400>  32
gacatctcta tgtcggccac                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T1080

<400>  33
tctctatgtc ggccactgga                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T628

<400>  34
agttgatgtg gtctgcgagt                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T4095

<400>  35
gcagaccaca tcaactttcc                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T10018

<400>  36
agttgccagg aaagttgatg                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T5023

<400>  37
tcaactttcc tggcaacttg                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T301

<400>  38
ctttcctggc aacttgcggt                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T524

<400>  39
aaaacctacc gcaagttgcc                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T5108

<400>  40
aaatagcaga ttctagagaa                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T1075

<400>  41
ctcacacaac tatgtagtcc                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T4110

<400>  42
tggactacat agttgtgtga                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T4668

<400>  43
ctggactaca tagttgtgtg                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T14792

<400>  44
gtttctgact accaagcatc                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T9263

<400>  45
atctgggcag agctgcatga                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T2985

<400>  46
ctgcccagat tgagctgagc                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T17331

<400>  47
gattgagctg agctggcctc                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T8686

<400>  48
tgtcaactcc agatgcagtc                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T3733

<400>  49
ttcagaaacc tgactgcatc                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T14704

<400>  50
aagtgcagtc aaaggctctg                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T13301

<400>  51
agtgcagtca aaggctctgg                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T701

<400>  52
tgtgccatgc tcgcaaagca                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T1529

<400>  53
aaatccttgc tttgcgagca                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T7959

<400>  54
ggcttgcaaa attagaaaac                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T9102

<400>  55
tgagaacact gaaacatccc                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T6907

<400>  56
gagaacactg aaacatccct                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T6332

<400>  57
catccctggg tgtgtccatc                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T10397

<400>  58
tttccagatg gacacaccca                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T8768

<400>  59
ttttccagat ggacacaccc                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T3638

<400>  60
aacggttgca aaattgccag                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T3091

<400>  61
gcaaccgttc tatttgaatt                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T12763

<400>  62
taaatattag ctaatctaac                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T11153

<400>  63
aataaattgg cagtgttatt                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T15222

<400>  64
ctttatgaac aaagatgtgg                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T361

<400>  65
agaggggggc caacgcgcac                                                   20


<210>  66
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T124

<400>  66
gaggggggcc aacgcgcacg                                                   20


<210>  67
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T3999

<400>  67
tgtctagttc aacctgagcc                                                   20


<210>  68
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T2823

<400>  68
tcactcctgc tctacagtta                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T14178

<400>  69
taactgtaga gcaggagtga                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T7777

<400>  70
gatggaactg cctgtttcat                                                   20


<210>  71
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T6609

<400>  71
tactaagcat tatcctttcc                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T14253

<400>  72
ctattttaac catttttgca                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T2338

<400>  73
ttggtggtac cctgcaaaaa                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T1079

<400>  74
ttttgcaggg taccaccaag                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T1149

<400>  75
ttgtcatggt gctttgcggt                                                   20


<210>  76
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T9705

<400>  76
agctttgtca tggtgctttg                                                   20


<210>  77
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T4738

<400>  77
gagtctatgt tccaaaaacc                                                   20


<210>  78
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T9197

<400>  78
tctccagggt tcagagagtc                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T14868

<400>  79
ctgccagact ctctgaaccc                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T9562

<400>  80
ttcagagagt ctggcagcat                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T11129

<400>  81
gtttccttgt gaacatgttg                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T4800

<400>  82
acgtccacaa catgttcaca                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T2131

<400>  83
tactttggga ctcaagtcta                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T549

<400>  84
ccaaagtagc gaattcaagt                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T843

<400>  85
ctacttgaat tcgctacttt                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T380

<400>  86
cctacttgaa ttcgctactt                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T5160

<400>  87
tatacatttg ggacagatct                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T5321

<400>  88
gatgatctga atatacattt                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T5793

<400>  89
ggatgatctg aatatacatt                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T8699

<400>  90
atgtatattc agatcatcca                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T5128

<400>  91
tgtatattca gatcatccaa                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T4836

<400>  92
gatcatccaa ggggacttct                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T2560

<400>  93
atcatccaag gggacttctt                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T3756

<400>  94
tcatccaagg ggacttcttg                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T4392

<400>  95
caagccccaa gaagtcccct                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T15881

<400>  96
ccactttagt ccctggccac                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T14561

<400>  97
gatttttctg gtagggaagg                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T17670

<400>  98
ctggtaggga aggaggtaga                                                   20


<210>  99
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T15228

<400>  99
ctgcacacaa tatctgagac                                                   20


<210>  100
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T6974

<400>  100
tccccaattg atttacaact                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T2436

<400>  101
ccccaattga tttacaactg                                                   20


<210>  102
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T12509

<400>  102
ggcttggata ctgttttaaa                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T5719

<400>  103
gcttggatac tgttttaaac                                                   20


<210>  104
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T1072

<400>  104
tggatactgt tttaaacggg                                                   20


<210>  105
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T2618

<400>  105
gttgtgtcaa gatggttagg                                                   20


<210>  106
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Intronic  lpa gene T2149

<400>  106
cgtcagtggt tgtgtcaaga                                                   20


<210>  107
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T1774

<400>  107
acgcaatgct cagacgcaga                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T192

<400>  108
agctccttat tgttatacga                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T413

<400>  109
atacgaggga tcccggtgtc                                                   20


<210>  110
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T9886

<400>  110
cacagactcc ttaccttgtt                                                   20


<210>  111
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T244

<400>  111
cagctcctta ttgttatacg                                                   20


<210>  112
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 5  T3893/T3894

<400>  112
catagatgac caagcttggc                                                   20


<210>  113
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T1503

<400>  113
cgagggatcc cggtgtcagg                                                   20


<210>  114
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T2071

<400>  114
cgcaatgctc agacgcagaa                                                   20


<210>  115
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T17437

<400>  115
cgcgcctccg actgttaccc                                                   20


<210>  116
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 5  T10325

<400>  116
cggtgctgaa atgaaaacac                                                   20


<210>  117
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T1278

<400>  117
ctagaggctc cttccgaaca                                                   20


<210>  118
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T214

<400>  118
ctgcgtctga gcattgcgtc                                                   20


<210>  119
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T4036

<400>  119
cttgttcgga aggagcctct                                                   20


<210>  120
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T205

<400>  120
gactccttac cttgttcgga                                                   20


<210>  121
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T1342

<400>  121
gagggatccc ggtgtcaggt                                                   20


<210>  122
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T4214

<400>  122
gcttgatcat gaactactgc                                                   20


<210>  123
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T1908

<400>  123
ggaaccgggg taacagtcgg                                                   20


<210>  124
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T146

<400>  124
ggatccctcg tataacaata                                                   20


<210>  125
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T228

<400>  125
ggctccttcc gaacaaggta                                                   20


<210>  126
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 5  T80

<400>  126
ggggtccgac tatgcgagtg                                                   20


<210>  127
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T53

<400>  127
ggtaacagtc ggaggcgcga                                                   20


<210>  128
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T315

<400>  128
tattgttata cgagggatcc                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 4  T10699

<400>  129
tcggaaggag cctctaggct                                                   20


<210>  130
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 5  T12307

<400>  130
tcggtgctga aatgaaaaca                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 5  T92

<400>  131
tgacaccaca ctcgcatagt                                                   20


<210>  132
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Kringle region  Exon 5  T14071

<400>  132
tggtagcact cctgcacccc                                                   20


<210>  133
<211>  6489
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Human apo a   coding sequence

<400>  133
aggtaccttt ggggctggct ttctcaagga agcccagctc cctgtgattg agaatgaagt       60

gtgcaatcgc tatgactggg attgggacac actttctggg cactgctggc cagtcccaaa      120

atggaacata aggaagtggt tcttctactt cttttatttc tgaaatcagc agcacctgag      180

caaagccatg tggtccagga ttgctaccat ggtgatggac agagttatcg aggcacgtac      240

tccaccactg tcacaggaag gacctgccaa gcttggtcat ctatgacacc acatcaacat      300

aataggacca cagaaaacta cccaaatgct ggcttgatca tgaactactg caggaatcca      360

gatgctgtgg cagctcctta ttgttatacg agggatcccg gtgtcaggtg ggagtactgc      420

aacctgacgc aatgctcaga cgcagaaggg actgccgtcg cgcctccgac tgttaccccg      480

gttccaagcc tagaggctcc ttccgaacaa gcaccgactg agcaaaggcc tggggtgcag      540

gagtgctacc atggtaatgg acagagttat cgaggcacat actccaccac tgtcacagga      600

agaacctgcc aagcttggtc atctatgaca ccacactcgc atagtcggac cccagaatac      660

tacccaaatg ctggcttgat catgaactac tgcaggaatc cagatgctgt ggcagctcct      720

tattgttata cgagggatcc cggtgtcagg tgggagtact gcaacctgac gcaatgctca      780

gacgcagaag ggactgccgt cgcgcctccg actgttaccc cggttccaag cctagaggct      840

ccttccgaac aagcaccgac tgagcaaagg cctggggtgc aggagtgcta ccatggtaat      900

ggacagagtt atcgaggcac atactccacc actgtcacag gaagaacctg ccaagcttgg      960

tcatctatga caccacactc gcatagtcgg accccagaat actacccaaa tgctggcttg     1020

atcatgaact actgcaggaa tccagatgct gtggcagctc cttattgtta tacgagggat     1080

cccggtgtca ggtgggagta ctgcaacctg acgcaatgct cagacgcaga agggactgcc     1140

gtcgcgcctc cgactgttac cccggttcca agcctagagg ctccttccga acaagcaccg     1200

actgagcaga ggcctggggt gcaggagtgc taccacggta atggacagag ttatcgaggc     1260

acatactcca ccactgtcac tggaagaacc tgccaagctt ggtcatctat gacaccacac     1320

tcgcatagtc ggaccccaga atactaccca aatgctggct tgatcatgaa ctactgcagg     1380

aatccagatg ctgtggcagc tccttattgt tatacgaggg atcccggtgt caggtgggag     1440

tactgcaacc tgacgcaatg ctcagacgca gaagggactg ccgtcgcgcc tccgactgtt     1500

accccggttc caagcctaga ggctccttcc gaacaagcac cgactgagca aaggcctggg     1560

gtgcaggagt gctaccatgg taatggacag agttatcgag gcacatactc caccactgtc     1620

acaggaagaa cctgccaagc ttggtcatct atgacaccac actcgcatag tcggacccca     1680

gaatactacc caaatgctgg cttgatcatg aactactgca ggaatccaga tgctgtggca     1740

gctccttatt gttatacgag ggatcccggt gtcaggtggg agtactgcaa cctgacgcaa     1800

tgctcagacg cagaagggac tgccgtcgcg cctccgactg ttaccccggt tccaagccta     1860

gaggctcctt ccgaacaagc accgactgag caaaggcctg gggtgcagga gtgctaccat     1920

ggtaatggac agagttatcg aggcacatac tccaccactg tcacaggaag aacctgccaa     1980

gcttggtcat ctatgacacc acactcgcat agtcggaccc cagaatacta cccaaatgct     2040

ggcttgatca tgaactactg caggaatcca gatgctgtgg cagctcctta ttgttatacg     2100

agggatcccg gtgtcaggtg ggagtactgc aacctgacgc aatgctcaga cgcagaaggg     2160

actgccgtcg cgcctccgac tgttaccccg gttccaagcc tagaggctcc ttccgaacaa     2220

gcaccgactg agcaaaggcc tggggtgcag gagtgctacc atggtaatgg acagagttat     2280

cgaggcacat actccaccac tgtcacagga agaacctgcc aagcttggtc atctatgaca     2340

ccacactcgc atagtcggac cccagaatac tacccaaatg ctggcttgat catgaactac     2400

tgcaggaatc cagatgctgt ggcagctcct tattgttata cgagggatcc cggtgtcagg     2460

tgggagtact gcaacctgac gcaatgctca gacgcagaag ggactgccgt cgcgcctccg     2520

actgttaccc cggttccaag cctagaggct ccttccgaac aagcaccgac tgagcagagg     2580

cctggggtgc aggagtgcta ccacggtaat ggacagagtt atcgaggcac atactccacc     2640

actgtcactg gaagaacctg ccaagcttgg tcatctatga caccacactc gcatagtcgg     2700

accccagaat actacccaaa tgctggcttg atcatgaact actgcaggaa tccagatcct     2760

gtggcagccc cttattgtta tacgagggat cccagtgtca ggtgggagta ctgcaacctg     2820

acacaatgct cagacgcaga agggactgcc gtcgcgcctc caactattac cccgattcca     2880

agcctagagg ctccttctga acaagcacca actgagcaaa ggcctggggt gcaggagtgc     2940

taccacggaa atggacagag ttatcaaggc acatacttca ttactgtcac aggaagaacc     3000

tgccaagctt ggtcatctat gacaccacac tcgcatagtc ggaccccagc atactaccca     3060

aatgctggct tgatcaagaa ctactgccga aatccagatc ctgtggcagc cccttggtgt     3120

tatacaacag atcccagtgt caggtgggag tactgcaacc tgacacgatg ctcagatgca     3180

gaatggactg ccttcgtccc tccgaatgtt attctggctc caagcctaga ggcttttttt     3240

gaacaagcac tgactgagga aacccccggg gtacaggact gctactacca ttatggacag     3300

agttaccgag gcacatactc caccactgtc acaggaagaa cttgccaagc ttggtcatct     3360

atgacaccac accagcatag tcggacccca gaaaactacc caaatgctgg cctgaccagg     3420

aactactgca ggaatccaga tgctgagatt cgcccttggt gttacaccat ggatcccagt     3480

gtcaggtggg agtactgcaa cctgacacaa tgcctggtga cagaatcaag tgtccttgca     3540

actctcacgg tggtcccaga tccaagcaca gaggcttctt ctgaagaagc accaacggag     3600

caaagccccg gggtccagga ttgctaccat ggtgatggac agagttatcg aggctcattc     3660

tctaccactg tcacaggaag gacatgtcag tcttggtcct ctatgacacc acactggcat     3720

cagaggacaa cagaatatta tccaaatggt ggcctgacca ggaactactg caggaatcca     3780

gatgctgaga ttagtccttg gtgttatacc atggatccca atgtcagatg ggagtactgc     3840

aacctgacac aatgtccagt gacagaatca agtgtccttg cgacgtccac ggctgtttct     3900

gaacaagcac caacggagca aagccccaca gtccaggact gctaccatgg tgatggacag     3960

agttatcgag gctcattctc caccactgtt acaggaagga catgtcagtc ttggtcctct     4020

atgacaccac actggcatca gagaaccaca gaatactacc caaatggtgg cctgaccagg     4080

aactactgca ggaatccaga tgctgagatt cgcccttggt gttataccat ggatcccagt     4140

gtcagatggg agtactgcaa cctgacgcaa tgtccagtga tggaatcaac tctcctcaca     4200

actcccacgg tggtcccagt tccaagcaca gagcttcctt ctgaagaagc accaactgaa     4260

aacagcactg gggtccagga ctgctaccga ggtgatggac agagttatcg aggcacactc     4320

tccaccacta tcacaggaag aacatgtcag tcttggtcgt ctatgacacc acattggcat     4380

cggaggatcc cattatacta tccaaatgct ggcctgacca ggaactactg caggaatcca     4440

gatgctgaga ttcgcccttg gtgttacacc atggatccca gtgtcaggtg ggagtactgc     4500

aacctgacac gatgtccagt gacagaatcg agtgtcctca caactcccac agtggccccg     4560

gttccaagca cagaggctcc ttctgaacaa gcaccacctg agaaaagccc tgtggtccag     4620

gattgctacc atggtgatgg acggagttat cgaggcatat cctccaccac tgtcacagga     4680

aggacctgtc aatcttggtc atctatgata ccacactggc atcagaggac cccagaaaac     4740

tacccaaatg ctggcctgac cgagaactac tgcaggaatc cagattctgg gaaacaaccc     4800

tggtgttaca caaccgatcc gtgtgtgagg tgggagtact gcaatctgac acaatgctca     4860

gaaacagaat caggtgtcct agagactccc actgttgttc cagttccaag catggaggct     4920

cattctgaag cagcaccaac tgagcaaacc cctgtggtcc ggcagtgcta ccatggtaat     4980

ggccagagtt atcgaggcac attctccacc actgtcacag gaaggacatg tcaatcttgg     5040

tcatccatga caccacaccg gcatcagagg accccagaaa actacccaaa tgatggcctg     5100

acaatgaact actgcaggaa tccagatgcc gatacaggcc cttggtgttt taccatggac     5160

cccagcatca ggtgggagta ctgcaacctg acgcgatgct cagacacaga agggactgtg     5220

gtcgctcctc cgactgtcat ccaggttcca agcctagggc ctccttctga acaagactgt     5280

atgtttggga atgggaaagg ataccggggc aagaaggcaa ccactgttac tgggacgcca     5340

tgccaggaat gggctgccca ggagccccat agacacagca cgttcattcc agggacaaat     5400

aaatgggcag gtctggaaaa aaattactgc cgtaaccctg atggtgacat caatggtccc     5460

tggtgctaca caatgaatcc aagaaaactt tttgactact gtgatatccc tctctgtgca     5520

tcctcttcat ttgattgtgg gaagcctcaa gtggagccga agaaatgtcc tggaagcatt     5580

gtaggggggt gtgtggccca cccacattcc tggccctggc aagtcagtct cagaacaagg     5640

tttggaaagc acttctgtgg aggcacctta atatccccag agtgggtgct gactgctgct     5700

cactgcttga agaagtcctc aaggccttca tcctacaagg tcatcctggg tgcacaccaa     5760

gaagtgaacc tcgaatctca tgttcaggaa atagaagtgt ctaggctgtt cttggagccc     5820

acacaagcag atattgcctt gctaaagcta agcaggcctg ccgtcatcac tgacaaagta     5880

atgccagctt gtctgccatc cccagactac atggtcaccg ccaggactga atgttacatc     5940

actggctggg gagaaaccca aggtaccttt gggactggcc ttctcaagga agcccagctc     6000

cttgttattg agaatgaagt gtgcaatcac tataagtata tttgtgctga gcatttggcc     6060

agaggcactg acagttgcca gggtgacagt ggagggcctc tggtttgctt cgagaaggac     6120

aaatacattt tacaaggagt cacttcttgg ggtcttggct gtgcacgccc caataagcct     6180

ggtgtctatg ctcgtgtttc aaggtttgtt acttggattg agggaatgat gagaaataat     6240

taattggacg ggagacagag tgaagcatca acctacttag aagctgaaac gtgggtaagg     6300

atttagcatg ctggaaataa tagacagcaa tcaaacgaag acactgttcc cagctaccag     6360

ctatgccaaa ccttggcatt tttggtattt ttgtgtataa gcttttaagg tctgactgac     6420

aaattctgta ttaaggtgtc atagctatga catttgttaa aaataaactc tgcacttatt     6480

ttgatttga                                                             6489


<210>  134
<211>  2040
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Human apo a   amino acid sequence

<400>  134

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Ala Ala Pro Glu Gln Ser His Val Val Gln Asp Cys Tyr His Gly Asp 
            20                  25                  30          


Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr 
        35                  40                  45              


Cys Gln Ala Trp Ser Ser Met Thr Pro His Gln His Asn Arg Thr Thr 
    50                  55                  60                  


Glu Asn Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro 
65                  70                  75                  80  


Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg 
                85                  90                  95      


Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala 
            100                 105                 110         


Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser 
        115                 120                 125             


Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His 
    130                 135                 140                 


Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly 
145                 150                 155                 160 


Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg 
                165                 170                 175     


Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg 
            180                 185                 190         


Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly 
        195                 200                 205             


Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly 
    210                 215                 220                 


Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala 
225                 230                 235                 240 


Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys 
                245                 250                 255     


Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val 
            260                 265                 270         


Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His 
        275                 280                 285             


Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr 
    290                 295                 300                 


Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp 
305                 310                 315                 320 


Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala 
                325                 330                 335     


Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu 
            340                 345                 350         


Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln 
        355                 360                 365             


Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr 
    370                 375                 380                 


Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His 
385                 390                 395                 400 


Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met 
                405                 410                 415     


Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr 
            420                 425                 430         


Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser 
        435                 440                 445             


Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro 
    450                 455                 460                 


Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly 
465                 470                 475                 480 


Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr 
                485                 490                 495     


Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr 
            500                 505                 510         


Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu 
        515                 520                 525             


Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys 
    530                 535                 540                 


Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln 
545                 550                 555                 560 


Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro 
                565                 570                 575     


Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg 
            580                 585                 590         


Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly 
        595                 600                 605             


Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser 
    610                 615                 620                 


Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala 
625                 630                 635                 640 


Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro 
                645                 650                 655     


Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu 
            660                 665                 670         


Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val 
        675                 680                 685             


Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu 
    690                 695                 700                 


Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr 
705                 710                 715                 720 


Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp 
                725                 730                 735     


Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro 
            740                 745                 750         


Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala 
        755                 760                 765             


Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys 
    770                 775                 780                 


Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro 
785                 790                 795                 800 


Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro 
                805                 810                 815     


Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln 
            820                 825                 830         


Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln 
        835                 840                 845             


Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr 
    850                 855                 860                 


Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Pro 
865                 870                 875                 880 


Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Ser Val Arg Trp Glu 
                885                 890                 895     


Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala 
            900                 905                 910         


Pro Pro Thr Ile Thr Pro Ile Pro Ser Leu Glu Ala Pro Ser Glu Gln 
        915                 920                 925             


Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn 
    930                 935                 940                 


Gly Gln Ser Tyr Gln Gly Thr Tyr Phe Ile Thr Val Thr Gly Arg Thr 
945                 950                 955                 960 


Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro 
                965                 970                 975     


Ala Tyr Tyr Pro Asn Ala Gly Leu Ile Lys Asn Tyr Cys Arg Asn Pro 
            980                 985                 990         


Asp Pro Val Ala Ala Pro Trp Cys  Tyr Thr Thr Asp Pro  Ser Val Arg 
        995                 1000                 1005             


Trp Glu  Tyr Cys Asn Leu Thr  Arg Cys Ser Asp Ala  Glu Trp Thr 
    1010                 1015                 1020             


Ala Phe  Val Pro Pro Asn Val  Ile Leu Ala Pro Ser  Leu Glu Ala 
    1025                 1030                 1035             


Phe Phe  Glu Gln Ala Leu Thr  Glu Glu Thr Pro Gly  Val Gln Asp 
    1040                 1045                 1050             


Cys Tyr  Tyr His Tyr Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    1055                 1060                 1065             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    1070                 1075                 1080             


His Gln  His Ser Arg Thr Pro  Glu Asn Tyr Pro Asn  Ala Gly Leu 
    1085                 1090                 1095             


Thr Arg  Asn Tyr Cys Arg Asn  Pro Asp Ala Glu Ile  Arg Pro Trp 
    1100                 1105                 1110             


Cys Tyr  Thr Met Asp Pro Ser  Val Arg Trp Glu Tyr  Cys Asn Leu 
    1115                 1120                 1125             


Thr Gln  Cys Leu Val Thr Glu  Ser Ser Val Leu Ala  Thr Leu Thr 
    1130                 1135                 1140             


Val Val  Pro Asp Pro Ser Thr  Glu Ala Ser Ser Glu  Glu Ala Pro 
    1145                 1150                 1155             


Thr Glu  Gln Ser Pro Gly Val  Gln Asp Cys Tyr His  Gly Asp Gly 
    1160                 1165                 1170             


Gln Ser  Tyr Arg Gly Ser Phe  Ser Thr Thr Val Thr  Gly Arg Thr 
    1175                 1180                 1185             


Cys Gln  Ser Trp Ser Ser Met  Thr Pro His Trp His  Gln Arg Thr 
    1190                 1195                 1200             


Thr Glu  Tyr Tyr Pro Asn Gly  Gly Leu Thr Arg Asn  Tyr Cys Arg 
    1205                 1210                 1215             


Asn Pro  Asp Ala Glu Ile Ser  Pro Trp Cys Tyr Thr  Met Asp Pro 
    1220                 1225                 1230             


Asn Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Pro Val Thr 
    1235                 1240                 1245             


Glu Ser  Ser Val Leu Ala Thr  Ser Thr Ala Val Ser  Glu Gln Ala 
    1250                 1255                 1260             


Pro Thr  Glu Gln Ser Pro Thr  Val Gln Asp Cys Tyr  His Gly Asp 
    1265                 1270                 1275             


Gly Gln  Ser Tyr Arg Gly Ser  Phe Ser Thr Thr Val  Thr Gly Arg 
    1280                 1285                 1290             


Thr Cys  Gln Ser Trp Ser Ser  Met Thr Pro His Trp  His Gln Arg 
    1295                 1300                 1305             


Thr Thr  Glu Tyr Tyr Pro Asn  Gly Gly Leu Thr Arg  Asn Tyr Cys 
    1310                 1315                 1320             


Arg Asn  Pro Asp Ala Glu Ile  Arg Pro Trp Cys Tyr  Thr Met Asp 
    1325                 1330                 1335             


Pro Ser  Val Arg Trp Glu Tyr  Cys Asn Leu Thr Gln  Cys Pro Val 
    1340                 1345                 1350             


Met Glu  Ser Thr Leu Leu Thr  Thr Pro Thr Val Val  Pro Val Pro 
    1355                 1360                 1365             


Ser Thr  Glu Leu Pro Ser Glu  Glu Ala Pro Thr Glu  Asn Ser Thr 
    1370                 1375                 1380             


Gly Val  Gln Asp Cys Tyr Arg  Gly Asp Gly Gln Ser  Tyr Arg Gly 
    1385                 1390                 1395             


Thr Leu  Ser Thr Thr Ile Thr  Gly Arg Thr Cys Gln  Ser Trp Ser 
    1400                 1405                 1410             


Ser Met  Thr Pro His Trp His  Arg Arg Ile Pro Leu  Tyr Tyr Pro 
    1415                 1420                 1425             


Asn Ala  Gly Leu Thr Arg Asn  Tyr Cys Arg Asn Pro  Asp Ala Glu 
    1430                 1435                 1440             


Ile Arg  Pro Trp Cys Tyr Thr  Met Asp Pro Ser Val  Arg Trp Glu 
    1445                 1450                 1455             


Tyr Cys  Asn Leu Thr Arg Cys  Pro Val Thr Glu Ser  Ser Val Leu 
    1460                 1465                 1470             


Thr Thr  Pro Thr Val Ala Pro  Val Pro Ser Thr Glu  Ala Pro Ser 
    1475                 1480                 1485             


Glu Gln  Ala Pro Pro Glu Lys  Ser Pro Val Val Gln  Asp Cys Tyr 
    1490                 1495                 1500             


His Gly  Asp Gly Arg Ser Tyr  Arg Gly Ile Ser Ser  Thr Thr Val 
    1505                 1510                 1515             


Thr Gly  Arg Thr Cys Gln Ser  Trp Ser Ser Met Ile  Pro His Trp 
    1520                 1525                 1530             


His Gln  Arg Thr Pro Glu Asn  Tyr Pro Asn Ala Gly  Leu Thr Glu 
    1535                 1540                 1545             


Asn Tyr  Cys Arg Asn Pro Asp  Ser Gly Lys Gln Pro  Trp Cys Tyr 
    1550                 1555                 1560             


Thr Thr  Asp Pro Cys Val Arg  Trp Glu Tyr Cys Asn  Leu Thr Gln 
    1565                 1570                 1575             


Cys Ser  Glu Thr Glu Ser Gly  Val Leu Glu Thr Pro  Thr Val Val 
    1580                 1585                 1590             


Pro Val  Pro Ser Met Glu Ala  His Ser Glu Ala Ala  Pro Thr Glu 
    1595                 1600                 1605             


Gln Thr  Pro Val Val Arg Gln  Cys Tyr His Gly Asn  Gly Gln Ser 
    1610                 1615                 1620             


Tyr Arg  Gly Thr Phe Ser Thr  Thr Val Thr Gly Arg  Thr Cys Gln 
    1625                 1630                 1635             


Ser Trp  Ser Ser Met Thr Pro  His Arg His Gln Arg  Thr Pro Glu 
    1640                 1645                 1650             


Asn Tyr  Pro Asn Asp Gly Leu  Thr Met Asn Tyr Cys  Arg Asn Pro 
    1655                 1660                 1665             


Asp Ala  Asp Thr Gly Pro Trp  Cys Phe Thr Met Asp  Pro Ser Ile 
    1670                 1675                 1680             


Arg Trp  Glu Tyr Cys Asn Leu  Thr Arg Cys Ser Asp  Thr Glu Gly 
    1685                 1690                 1695             


Thr Val  Val Ala Pro Pro Thr  Val Ile Gln Val Pro  Ser Leu Gly 
    1700                 1705                 1710             


Pro Pro  Ser Glu Gln Asp Cys  Met Phe Gly Asn Gly  Lys Gly Tyr 
    1715                 1720                 1725             


Arg Gly  Lys Lys Ala Thr Thr  Val Thr Gly Thr Pro  Cys Gln Glu 
    1730                 1735                 1740             


Trp Ala  Ala Gln Glu Pro His  Arg His Ser Thr Phe  Ile Pro Gly 
    1745                 1750                 1755             


Thr Asn  Lys Trp Ala Gly Leu  Glu Lys Asn Tyr Cys  Arg Asn Pro 
    1760                 1765                 1770             


Asp Gly  Asp Ile Asn Gly Pro  Trp Cys Tyr Thr Met  Asn Pro Arg 
    1775                 1780                 1785             


Lys Leu  Phe Asp Tyr Cys Asp  Ile Pro Leu Cys Ala  Ser Ser Ser 
    1790                 1795                 1800             


Phe Asp  Cys Gly Lys Pro Gln  Val Glu Pro Lys Lys  Cys Pro Gly 
    1805                 1810                 1815             


Ser Ile  Val Gly Gly Cys Val  Ala His Pro His Ser  Trp Pro Trp 
    1820                 1825                 1830             


Gln Val  Ser Leu Arg Thr Arg  Phe Gly Lys His Phe  Cys Gly Gly 
    1835                 1840                 1845             


Thr Leu  Ile Ser Pro Glu Trp  Val Leu Thr Ala Ala  His Cys Leu 
    1850                 1855                 1860             


Lys Lys  Ser Ser Arg Pro Ser  Ser Tyr Lys Val Ile  Leu Gly Ala 
    1865                 1870                 1875             


His Gln  Glu Val Asn Leu Glu  Ser His Val Gln Glu  Ile Glu Val 
    1880                 1885                 1890             


Ser Arg  Leu Phe Leu Glu Pro  Thr Gln Ala Asp Ile  Ala Leu Leu 
    1895                 1900                 1905             


Lys Leu  Ser Arg Pro Ala Val  Ile Thr Asp Lys Val  Met Pro Ala 
    1910                 1915                 1920             


Cys Leu  Pro Ser Pro Asp Tyr  Met Val Thr Ala Arg  Thr Glu Cys 
    1925                 1930                 1935             


Tyr Ile  Thr Gly Trp Gly Glu  Thr Gln Gly Thr Phe  Gly Thr Gly 
    1940                 1945                 1950             


Leu Leu  Lys Glu Ala Gln Leu  Leu Val Ile Glu Asn  Glu Val Cys 
    1955                 1960                 1965             


Asn His  Tyr Lys Tyr Ile Cys  Ala Glu His Leu Ala  Arg Gly Thr 
    1970                 1975                 1980             


Asp Ser  Cys Gln Gly Asp Ser  Gly Gly Pro Leu Val  Cys Phe Glu 
    1985                 1990                 1995             


Lys Asp  Lys Tyr Ile Leu Gln  Gly Val Thr Ser Trp  Gly Leu Gly 
    2000                 2005                 2010             


Cys Ala  Arg Pro Asn Lys Pro  Gly Val Tyr Ala Arg  Val Ser Arg 
    2015                 2020                 2025             


Phe Val  Thr Trp Ile Glu Gly  Met Met Arg Asn Asn  
    2030                 2035                 2040 


<210>  135
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  LPAF  forward primer

<400>  135
gcacgtctgt ctgcctgcta a                                                 21


<210>  136
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  LPAR  reverse primer

<400>  136
cttcctggca acccgtattc cttc                                              24


<210>  137
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  LPA TIDE F  sequencing primer

<400>  137
caagagaaga gaatggtcg                                                    19


<210>  138
<211>  4438
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  spCas9 mRNA

<400>  138
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg ccccaaagaa       60

gaagcggaag gtcggtatcc acggagtccc agcagccgac aagaagtaca gcatcggcct      120

ggacatcggc accaactctg tgggctgggc cgtgatcacc gacgagtaca aggtgcccag      180

caagaaattc aaggtgctgg gcaacaccga ccggcacagc atcaagaaga acctgatcgg      240

agccctgctg ttcgacagcg gcgaaacagc cgaggccacc cggctgaaga gaaccgccag      300

aagaagatac accagacgga agaaccggat ctgctatctg caagagatct tcagcaacga      360

gatggccaag gtggacgaca gcttcttcca cagactggaa gagtccttcc tggtggaaga      420

ggacaagaag cacgagagac accccatctt cggcaacatc gtggacgagg tggcctacca      480

cgagaagtac cccaccatct accacctgag aaagaaactg gtggacagca ccgacaaggc      540

cgacctgaga ctgatctacc tggccctggc ccacatgatc aagttcagag gccacttcct      600

gatcgagggc gacctgaacc ccgacaacag cgacgtggac aagctgttca tccagctggt      660

gcagacctac aaccagctgt tcgaggaaaa ccccatcaac gccagcggcg tggacgccaa      720

ggctatcctg tctgccagac tgagcaagag cagaaggctg gaaaatctga tcgcccagct      780

gcccggcgag aagaagaacg gcctgttcgg caacctgatt gccctgagcc tgggcctgac      840

ccccaacttc aagagcaact tcgacctggc cgaggatgcc aaactgcagc tgagcaagga      900

cacctacgac gacgacctgg acaacctgct ggcccagatc ggcgaccagt acgccgacct      960

gttcctggcc gccaagaacc tgtctgacgc catcctgctg agcgacatcc tgagagtgaa     1020

caccgagatc accaaggccc ccctgagcgc ctctatgatc aagagatacg acgagcacca     1080

ccaggacctg accctgctga aagctctcgt gcggcagcag ctgcctgaga agtacaaaga     1140

aatcttcttc gaccagagca agaacggcta cgccggctac atcgatggcg gcgctagcca     1200

ggaagagttc tacaagttca tcaagcccat cctggaaaag atggacggca ccgaggaact     1260

gctcgtgaag ctgaacagag aggacctgct gagaaagcag agaaccttcg acaacggcag     1320

catcccccac cagatccacc tgggagagct gcacgctatc ctgagaaggc aggaagattt     1380

ttacccattc ctgaaggaca accgggaaaa gatcgagaag atcctgacct tcaggatccc     1440

ctactacgtg ggccccctgg ccagaggcaa cagcagattc gcctggatga ccagaaagag     1500

cgaggaaacc atcaccccct ggaacttcga ggaagtggtg gacaagggcg ccagcgccca     1560

gagcttcatc gagagaatga caaacttcga taagaacctg cccaacgaga aggtgctgcc     1620

caagcacagc ctgctgtacg agtacttcac cgtgtacaac gagctgacca aagtgaaata     1680

cgtgaccgag ggaatgagaa agcccgcctt cctgagcggc gagcagaaaa aggccatcgt     1740

ggacctgctg ttcaagacca acagaaaagt gaccgtgaag cagctgaaag aggactactt     1800

caagaaaatc gagtgcttcg actccgtgga aatctccggc gtggaagata gattcaacgc     1860

ctccctgggc acataccacg atctgctgaa aattatcaag gacaaggact tcctggataa     1920

cgaagagaac gaggacattc tggaagatat cgtgctgacc ctgacactgt ttgaggaccg     1980

cgagatgatc gaggaaaggc tgaaaaccta cgctcacctg ttcgacgaca aagtgatgaa     2040

gcagctgaag agaaggcggt acaccggctg gggcaggctg agcagaaagc tgatcaacgg     2100

catcagagac aagcagagcg gcaagacaat cctggatttc ctgaagtccg acggcttcgc     2160

caaccggaac ttcatgcagc tgatccacga cgacagcctg acattcaaag aggacatcca     2220

gaaagcccag gtgtccggcc agggcgactc tctgcacgag catatcgcta acctggccgg     2280

cagccccgct atcaagaagg gcatcctgca gacagtgaag gtggtggacg agctcgtgaa     2340

agtgatgggc agacacaagc ccgagaacat cgtgatcgag atggctagag agaaccagac     2400

cacccagaag ggacagaaga actcccgcga gaggatgaag agaatcgaag agggcatcaa     2460

agagctgggc agccagatcc tgaaagaaca ccccgtggaa aacacccagc tgcagaacga     2520

gaagctgtac ctgtactacc tgcagaatgg ccgggatatg tacgtggacc aggaactgga     2580

catcaacaga ctgtccgact acgatgtgga ccatatcgtg cctcagagct ttctgaagga     2640

cgactccatc gataacaaag tgctgactcg gagcgacaag aacagaggca agagcgacaa     2700

cgtgccctcc gaagaggtcg tgaagaagat gaagaactac tggcgacagc tgctgaacgc     2760

caagctgatt acccagagga agttcgataa cctgaccaag gccgagagag gcggcctgag     2820

cgagctggat aaggccggct tcatcaagag gcagctggtg gaaaccagac agatcacaaa     2880

gcacgtggca cagatcctgg actcccggat gaacactaag tacgacgaaa acgataagct     2940

gatccgggaa gtgaaagtga tcaccctgaa gtccaagctg gtgtccgatt tccggaagga     3000

tttccagttt tacaaagtgc gcgagatcaa caactaccac cacgcccacg acgcctacct     3060

gaacgccgtc gtgggaaccg ccctgatcaa aaagtaccct aagctggaaa gcgagttcgt     3120

gtacggcgac tacaaggtgt acgacgtgcg gaagatgatc gccaagagcg agcaggaaat     3180

cggcaaggct accgccaagt acttcttcta cagcaacatc atgaactttt tcaagaccga     3240

aatcaccctg gccaacggcg agatcagaaa gcgccctctg atcgagacaa acggcgaaac     3300

cggggagatc gtgtgggata agggcagaga cttcgccaca gtgcgaaagg tgctgagcat     3360

gccccaagtg aatatcgtga aaaagaccga ggtgcagaca ggcggcttca gcaaagagtc     3420

tatcctgccc aagaggaaca gcgacaagct gatcgccaga aagaaggact gggaccccaa     3480

gaagtacggc ggcttcgaca gccctaccgt ggcctactct gtgctggtgg tggctaaggt     3540

ggaaaagggc aagtccaaga aactgaagag tgtgaaagag ctgctgggga tcaccatcat     3600

ggaaagaagc agctttgaga agaaccctat cgactttctg gaagccaagg gctacaaaga     3660

agtgaaaaag gacctgatca tcaagctgcc taagtactcc ctgttcgagc tggaaaacgg     3720

cagaaagaga atgctggcct ctgccggcga actgcagaag ggaaacgagc tggccctgcc     3780

tagcaaatat gtgaacttcc tgtacctggc ctcccactat gagaagctga agggcagccc     3840

tgaggacaac gaacagaaac agctgtttgt ggaacagcat aagcactacc tggacgagat     3900

catcgagcag atcagcgagt tctccaagag agtgatcctg gccgacgcca atctggacaa     3960

ggtgctgtct gcctacaaca agcacaggga caagcctatc agagagcagg ccgagaatat     4020

catccacctg ttcaccctga caaacctggg cgctcctgcc gccttcaagt actttgacac     4080

caccatcgac cggaagaggt acaccagcac caaagaggtg ctggacgcca ccctgatcca     4140

ccagagcatc accggcctgt acgagacaag aatcgacctg tctcagctgg gaggcgacaa     4200

gagacctgcc gccactaaga aggccggaca ggccaaaaag aagaagtgag cggccgctta     4260

attaagctgc cttctgcggg gcttgccttc tggccatgcc cttcttctct cccttgcacc     4320

tgtacctctt ggtctttgaa taaagcctga gtaggaagaa aaaaaaaaaa aaaaaaaaaa     4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa       4438


<210>  139
<211>  200
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Partial LPA gene sequence

<400>  139
tctgttttaa ttttagcagc acctgagcaa agccatgtgg tccaggattg ctaccatggt       60

gatggacaga gttatcgagg cacgtactcc accactgtca caggaaggac ctgccaagct      120

tggtcatcta tgacaccaca tcaacataat aggaccacag aaaactaccc aaatgcgtat      180

gtcattaatc ttacagtaag                                                  200


<210>  140
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR1 Primer F

<400>  140
acatttctaa ccaccatccc c                                                 21


<210>  141
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR1 Primer R

<400>  141
ctcccaataa cactgccaat tt                                                22


<210>  142
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR1 TIDE Primer F

<400>  142
ggtcaattgg cgttctcagc                                                   20


<210>  143
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR3 Primer F

<400>  143
ggcatttagt acattcacag tgg                                               23


<210>  144
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR3 Primer R

<400>  144
agacacgcca actctgatca                                                   20


<210>  145
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR3 TIDE Primer F

<400>  145
gttatgaaga tcatagcact atac                                              24


<210>  146
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR5 Primer F

<400>  146
gggtctggtc atggaagtta cc                                                22


<210>  147
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR5 Primer R

<400>  147
cgaagagctt agccatcctt tg                                                22


<210>  148
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR5 TIDE Primer F

<400>  148
gaggaaacaa gactaatcag g                                                 21


<210>  149
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR7 Primer F

<400>  149
tcctccttga tgccatgttt                                                   20


<210>  150
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR7 Primer R

<400>  150
ctgggacact gaggtagcc                                                    19


<210>  151
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR7 TIDE Primer F

<400>  151
gatgccatgt tttctctgaa g                                                 21


<210>  152
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR10 Primer F

<400>  152
cgttttttgc ccacgtgtat g                                                 21


<210>  153
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR10 Primer R

<400>  153
cacccaacgt tgtaccagaa                                                   20


<210>  154
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hLPA PCR10 TIDE Primer F

<400>  154
cgtgtatgta ttatctcagt g                                                 21


<210>  155
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Stop codon donor template

<400>  155
taggtaggta ggtaggtagg tagctaccta cctacctacc taccta                      46


<210>  156
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Target sequence with NRG PAM

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  N is any nucleotide

<400>  156
nnnnnnnnnn nnnnnnnnnn nrg                                               23


<210>  157
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 3  T1 19

<400>  157
ggaccacatg gctttgctc                                                    19


<210>  158
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 3  T2 19

<400>  158
gagcaaagcc atgtggtcc                                                    19


<210>  159
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 3  T4 19

<400>  159
attaatgaca tacgcattt                                                    19


<210>  160
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Exon 3  T5 19

<400>  160
gattaatgac atacgcatt                                                    19


<210>  161
<211>  80
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA tracrRNA scaffold

<400>  161
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu                                                   80


<210>  162
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  ddPCR primer 1

<400>  162
tttctgaaca agcaccaacg                                                   20


<210>  163
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  ddPCR primer 2

<400>  163
aacagtggtg gagaatgag                                                    19


<210>  164
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  ddPCR detection probe

<400>  164
cccacagtcc aggactgcta                                                   20


<210>  165
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  control AAVS1 spacer

<400>  165
ggggccacta gggacaggat                                                   20


