                         SEQUENCE LISTING

<110>  Innate Pharma et al.,
 
<120>  METHODS FOR TREATING CANCER

<130>  PCT 140295

<150>  102018000004853
<151>  2018-04-24

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Trp Arg Ala Leu His Pro Leu Leu Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Pro Gly Ser Gln Ala Gln Ser Lys Ala Gln Val Leu Gln Ser Val Ala 
            20                  25                  30          


Gly Gln Thr Leu Thr Val Arg Cys Gln Tyr Pro Pro Thr Gly Ser Leu 
        35                  40                  45              


Tyr Glu Lys Lys Gly Trp Cys Lys Glu Ala Ser Ala Leu Val Cys Ile 
    50                  55                  60                  


Arg Leu Val Thr Ser Ser Lys Pro Arg Thr Met Ala Trp Thr Ser Arg 
65                  70                  75                  80  


Phe Thr Ile Trp Asp Asp Pro Asp Ala Gly Phe Phe Thr Val Thr Met 
                85                  90                  95      


Thr Asp Leu Arg Glu Glu Asp Ser Gly His Tyr Trp Cys Arg Ile Tyr 
            100                 105                 110         


Arg Pro Ser Asp Asn Ser Val Ser Lys Ser Val Arg Phe Tyr Leu Val 
        115                 120                 125             


Val Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp 
    130                 135                 140                 


Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala 
145                 150                 155                 160 


Gly Ala Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser 
                165                 170                 175     


Gln Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Ala Ala Pro Ile Ala 
            180                 185                 190         


Leu Val Pro Val Phe Cys Gly Leu Leu Val Ala Lys Ser Leu Val Leu 
        195                 200                 205             


Ser Ala Leu Leu Val Trp Trp Gly Asp Ile Trp Trp Lys Thr Met Met 
    210                 215                 220                 


Glu Leu Arg Ser Leu Asp Thr Gln Lys Ala Thr Cys His Leu Gln Gln 
225                 230                 235                 240 


Val Thr Asp Leu Pro Trp Thr Ser Val Ser Ser Pro Val Glu Arg Glu 
                245                 250                 255     


Ile Leu Tyr His Thr Val Ala Arg Thr Lys Ile Ser Asp Asp Asp Asp 
            260                 265                 270         


Glu His Thr Leu 
        275     


<210>  2
<211>  1219
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Ser Arg Gln Glu Leu Phe Pro Phe Gly Pro Gly Gln Gly Asp Leu 
1               5                   10                  15      


Glu Leu Glu Asp Gly Asp Asp Phe Val Ser Pro Ala Leu Glu Leu Ser 
            20                  25                  30          


Gly Ala Leu Arg Phe Tyr Asp Arg Ser Asp Ile Asp Ala Val Tyr Val 
        35                  40                  45              


Thr Thr Asn Gly Ile Ile Ala Thr Ser Glu Pro Pro Ala Lys Glu Ser 
    50                  55                  60                  


His Pro Gly Leu Phe Pro Pro Thr Phe Gly Ala Val Ala Pro Phe Leu 
65                  70                  75                  80  


Ala Asp Leu Asp Thr Thr Asp Gly Leu Gly Lys Val Tyr Tyr Arg Glu 
                85                  90                  95      


Asp Leu Ser Pro Ser Ile Thr Gln Arg Ala Ala Glu Cys Val His Arg 
            100                 105                 110         


Gly Phe Pro Glu Ile Ser Phe Gln Pro Ser Ser Ala Val Val Val Thr 
        115                 120                 125             


Trp Glu Ser Val Ala Pro Tyr Gln Gly Pro Ser Arg Asp Pro Asp Gln 
    130                 135                 140                 


Lys Gly Lys Arg Asn Thr Phe Gln Ala Val Leu Ala Ser Ser Asp Ser 
145                 150                 155                 160 


Ser Ser Tyr Ala Ile Phe Leu Tyr Pro Glu Asp Gly Leu Gln Phe His 
                165                 170                 175     


Thr Thr Phe Ser Lys Lys Glu Asn Asn Gln Val Pro Ala Val Val Ala 
            180                 185                 190         


Phe Ser Gln Gly Ser Val Gly Phe Leu Trp Lys Ser Asn Gly Ala Tyr 
        195                 200                 205             


Asn Ile Phe Ala Asn Asp Arg Glu Ser Val Glu Asn Leu Ala Lys Ser 
    210                 215                 220                 


Ser Asn Ser Gly Gln Gln Gly Val Trp Val Phe Glu Ile Gly Ser Pro 
225                 230                 235                 240 


Ala Thr Thr Asn Gly Val Val Pro Ala Asp Val Ile Leu Gly Thr Glu 
                245                 250                 255     


Asp Gly Ala Glu Tyr Asp Asp Glu Asp Glu Asp Tyr Asp Leu Ala Thr 
            260                 265                 270         


Thr Arg Leu Gly Leu Glu Asp Val Gly Thr Thr Pro Phe Ser Tyr Lys 
        275                 280                 285             


Ala Leu Arg Arg Gly Gly Ala Asp Thr Tyr Ser Val Pro Ser Val Leu 
    290                 295                 300                 


Ser Pro Arg Arg Ala Ala Thr Glu Arg Pro Leu Gly Pro Pro Thr Glu 
305                 310                 315                 320 


Arg Thr Arg Ser Phe Gln Leu Ala Val Glu Thr Phe His Gln Gln His 
                325                 330                 335     


Pro Gln Val Ile Asp Val Asp Glu Val Glu Glu Thr Gly Val Val Phe 
            340                 345                 350         


Ser Tyr Asn Thr Asp Ser Arg Gln Thr Cys Ala Asn Asn Arg His Gln 
        355                 360                 365             


Cys Ser Val His Ala Glu Cys Arg Asp Tyr Ala Thr Gly Phe Cys Cys 
    370                 375                 380                 


Ser Cys Val Ala Gly Tyr Thr Gly Asn Gly Arg Gln Cys Val Ala Glu 
385                 390                 395                 400 


Gly Ser Pro Gln Arg Val Asn Gly Lys Val Lys Gly Arg Ile Phe Val 
                405                 410                 415     


Gly Ser Ser Gln Val Pro Ile Val Phe Glu Asn Thr Asp Leu His Ser 
            420                 425                 430         


Tyr Val Val Met Asn His Gly Arg Ser Tyr Thr Ala Ile Ser Thr Ile 
        435                 440                 445             


Pro Glu Thr Val Gly Tyr Ser Leu Leu Pro Leu Ala Pro Val Gly Gly 
    450                 455                 460                 


Ile Ile Gly Trp Met Phe Ala Val Glu Gln Asp Gly Phe Lys Asn Gly 
465                 470                 475                 480 


Phe Ser Ile Thr Gly Gly Glu Phe Thr Arg Gln Ala Glu Val Thr Phe 
                485                 490                 495     


Val Gly His Pro Gly Asn Leu Val Ile Lys Gln Arg Phe Ser Gly Ile 
            500                 505                 510         


Asp Glu His Gly His Leu Thr Ile Asp Thr Glu Leu Glu Gly Arg Val 
        515                 520                 525             


Pro Gln Ile Pro Phe Gly Ser Ser Val His Ile Glu Pro Tyr Thr Glu 
    530                 535                 540                 


Leu Tyr His Tyr Ser Thr Ser Val Ile Thr Ser Ser Ser Thr Arg Glu 
545                 550                 555                 560 


Tyr Thr Val Thr Glu Pro Glu Arg Asp Gly Ala Ser Pro Ser Arg Ile 
                565                 570                 575     


Tyr Thr Tyr Gln Trp Arg Gln Thr Ile Thr Phe Gln Glu Cys Val His 
            580                 585                 590         


Asp Asp Ser Arg Pro Ala Leu Pro Ser Thr Gln Gln Leu Ser Val Asp 
        595                 600                 605             


Ser Val Phe Val Leu Tyr Asn Gln Glu Glu Lys Ile Leu Arg Tyr Ala 
    610                 615                 620                 


Leu Ser Asn Ser Ile Gly Pro Val Arg Glu Gly Ser Pro Asp Ala Leu 
625                 630                 635                 640 


Gln Asn Pro Cys Tyr Ile Gly Thr His Gly Cys Asp Thr Asn Ala Ala 
                645                 650                 655     


Cys Arg Pro Gly Pro Arg Thr Gln Phe Thr Cys Glu Cys Ser Ile Gly 
            660                 665                 670         


Phe Arg Gly Asp Gly Arg Thr Cys Tyr Asp Ile Asp Glu Cys Ser Glu 
        675                 680                 685             


Gln Pro Ser Val Cys Gly Ser His Thr Ile Cys Asn Asn His Pro Gly 
    690                 695                 700                 


Thr Phe Arg Cys Glu Cys Val Glu Gly Tyr Gln Phe Ser Asp Glu Gly 
705                 710                 715                 720 


Thr Cys Val Ala Val Val Asp Gln Arg Pro Ile Asn Tyr Cys Glu Thr 
                725                 730                 735     


Gly Leu His Asn Cys Asp Ile Pro Gln Arg Ala Gln Cys Ile Tyr Thr 
            740                 745                 750         


Gly Gly Ser Ser Tyr Thr Cys Ser Cys Leu Pro Gly Phe Ser Gly Asp 
        755                 760                 765             


Gly Gln Ala Cys Gln Asp Val Asp Glu Cys Gln Pro Ser Arg Cys His 
    770                 775                 780                 


Pro Asp Ala Phe Cys Tyr Asn Thr Pro Gly Ser Phe Thr Cys Gln Cys 
785                 790                 795                 800 


Lys Pro Gly Tyr Gln Gly Asp Gly Phe Arg Cys Val Pro Gly Glu Val 
                805                 810                 815     


Glu Lys Thr Arg Cys Gln His Glu Arg Glu His Ile Leu Gly Ala Ala 
            820                 825                 830         


Gly Ala Thr Asp Pro Gln Arg Pro Ile Pro Pro Gly Leu Phe Val Pro 
        835                 840                 845             


Glu Cys Asp Ala His Gly His Tyr Ala Pro Thr Gln Cys His Gly Ser 
    850                 855                 860                 


Thr Gly Tyr Cys Trp Cys Val Asp Arg Asp Gly Arg Glu Val Glu Gly 
865                 870                 875                 880 


Thr Arg Thr Arg Pro Gly Met Thr Pro Pro Cys Leu Ser Thr Val Ala 
                885                 890                 895     


Pro Pro Ile His Gln Gly Pro Ala Val Pro Thr Ala Val Ile Pro Leu 
            900                 905                 910         


Pro Pro Gly Thr His Leu Leu Phe Ala Gln Thr Gly Lys Ile Glu Arg 
        915                 920                 925             


Leu Pro Leu Glu Gly Asn Thr Met Arg Lys Thr Glu Ala Lys Ala Phe 
    930                 935                 940                 


Leu His Val Pro Ala Lys Val Ile Ile Gly Leu Ala Phe Asp Cys Val 
945                 950                 955                 960 


Asp Lys Met Val Tyr Trp Thr Asp Ile Thr Glu Pro Ser Ile Gly Arg 
                965                 970                 975     


Ala Ser Leu His Gly Gly Glu Pro Thr Thr Ile Ile Arg Gln Asp Leu 
            980                 985                 990         


Gly Ser Pro Glu Gly Ile Ala Val  Asp His Leu Gly Arg  Asn Ile Phe 
        995                 1000                 1005             


Trp Thr  Asp Ser Asn Leu Asp  Arg Ile Glu Val Ala  Lys Leu Asp 
    1010                 1015                 1020             


Gly Thr  Gln Arg Arg Val Leu  Phe Glu Thr Asp Leu  Val Asn Pro 
    1025                 1030                 1035             


Arg Gly  Ile Val Thr Asp Ser  Val Arg Gly Asn Leu  Tyr Trp Thr 
    1040                 1045                 1050             


Asp Trp  Asn Arg Asp Asn Pro  Lys Ile Glu Thr Ser  Tyr Met Asp 
    1055                 1060                 1065             


Gly Thr  Asn Arg Arg Ile Leu  Val Gln Asp Asp Leu  Gly Leu Pro 
    1070                 1075                 1080             


Asn Gly  Leu Thr Phe Asp Ala  Phe Ser Ser Gln Leu  Cys Trp Val 
    1085                 1090                 1095             


Asp Ala  Gly Thr Asn Arg Ala  Glu Cys Leu Asn Pro  Ser Gln Pro 
    1100                 1105                 1110             


Ser Arg  Arg Lys Ala Leu Glu  Gly Leu Gln Tyr Pro  Phe Ala Val 
    1115                 1120                 1125             


Thr Ser  Tyr Gly Lys Asn Leu  Tyr Phe Thr Asp Trp  Lys Met Asn 
    1130                 1135                 1140             


Ser Val  Val Ala Leu Asp Leu  Ala Ile Ser Lys Glu  Thr Asp Ala 
    1145                 1150                 1155             


Phe Gln  Pro His Lys Gln Thr  Arg Leu Tyr Gly Ile  Thr Thr Ala 
    1160                 1165                 1170             


Leu Ser  Gln Cys Pro Gln Gly  His Asn Tyr Cys Ser  Val Asn Asn 
    1175                 1180                 1185             


Gly Gly  Cys Thr His Leu Cys  Leu Ala Thr Pro Gly  Ser Arg Thr 
    1190                 1195                 1200             


Cys Arg  Cys Pro Asp Asn Thr  Leu Gly Val Asp Cys  Ile Glu Gln 
    1205                 1210                 1215             


Lys 
    


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3
actccatcat gaagtgtgac g                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4
catactcctg cttgctgatc c                                                 21


<210>  5
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5
ctccattggg cctgtgagg                                                    19


<210>  6
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6
agacacgggg gcgtcatc                                                     18


<210>  7
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Ala Ser Ser Ser Arg Ile Arg Ala Ala Trp Thr Arg Ala Leu 
1               5                   10                  15      


Leu Leu Pro Leu Leu Leu Ala Gly Pro Val Gly Cys 
            20                  25              


