                         SEQUENCE LISTING

<110>  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
	The Beth Israel Deaconess Medical Center, Inc.
	The Government of the United States as represented by the Secretary of the Army
	Shelly Krebs
	Gina Donofrio
	Vincent Dussupt
	Kayvon Modjarrad
	Dan Barouch
	Richard G. Jarman, III
	Nelson L. Michael

 
<120>  POTENT ZIKA VIRUS-SPECIFIC AND CROSS-NEUTRALIZING MONOCLONAL ANTIBODIES TO ZIKA AND DENGUE VIRUSES FOLLOWING ZIKV INFECTION OR VACCINATION

<130>  044508-5089-WO

<150>  62/662,211
<151>  2018-04-24

<150>  62/697,347
<151>  2018-07-12

<160>  236   

<170>  PatentIn version 3.5

<210>  1
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ100 heavy chain variable domain nucleotide sequence

<400>  1
gaggtgcagc tggtggagtc tggaggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agtgatggca tgagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcttac attagtagtg gtggtgctac cacatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca actctaagaa cacgctctcc      240

ctgcaaatga acagcctgag aggtgaggac acggccgtgt actactgtgc gaaagacata      300

acggcacctg gaaggaatgg tttggattcc tggggccaag gggtcgtcgt caccgtctcc      360

tca                                                                    363


<210>  2
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ100 light chain variable domain nucleotide sequence

<400>  2
cagtctgtgc tgactcagcc accctccctg tctgcatccc cgggagcatc ggccagactc       60

ccctgcaccc tgagcagtga cctcaatgtt ggtactaaaa acatgtactg gtaccagcag      120

aagccaggga gcgctcccag gttattcctg tactactact ccgactcaga caagcagctg      180

ggacctgggg tccccaatcg agtctctggc tccaaggaga cctcaagtaa cacagcgttt      240

ttgctcatct ctgggctcca gcctgaggac gaggccgatt attactgtca ggtatatgac      300

aatagtgcta gggtattcgg cggagggacc cggctgaccg tcctag                     346


<210>  3
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ100 heavy chain variable domain amino acid sequence

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Gly Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Thr Ala Pro Gly Arg Asn Gly Leu Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Val Val Val Thr Val Ser Ser 
        115                 120     


<210>  4
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ100 light chain variable domain amino acid sequence

<400>  4

Gln Ser Val Leu Thr Gln Pro Pro Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Arg Leu Pro Cys Thr Leu Ser Ser Asp Leu Asn Val Gly Thr 
            20                  25                  30          


Lys Asn Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Arg Leu 
        35                  40                  45              


Phe Leu Tyr Tyr Tyr Ser Asp Ser Asp Lys Gln Leu Gly Pro Gly Val 
    50                  55                  60                  


Pro Asn Arg Val Ser Gly Ser Lys Glu Thr Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Gln Val Tyr Asp Asn Ser Ala Arg Val Phe Gly Gly Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Gly 
        115     


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ100 heavy chain CDR1 sequence

<400>  5

Gly Phe Thr Phe Ser Ser Asp Gly 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ100 heavy chain CDR2 sequence

<400>  6

Ile Ser Ser Gly Gly Ala Thr Thr 
1               5               


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ100 heavy chain CDR3 sequence

<400>  7

Cys Ala Lys Asp Ile Thr Ala Pro Gly Arg Asn Gly Leu Asp Ser Trp 
1               5                   10                  15      


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ100 light chain CDR1 sequence

<400>  8

Ser Asp Leu Asn Val Gly Thr Lys Asn 
1               5                   


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ100 light chain CDR2 sequence

<400>  9

Tyr Tyr Ser Asp Ser Asp Lys 
1               5           


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ100 light chain CDR3 sequence

<400>  10

Cys Gln Val Tyr Asp Asn Ser Ala Arg Val Phe 
1               5                   10      


<210>  11
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ101 heavy chain variable domain nucleotide sequence

<400>  11
gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagcttcagt gactactaca tgtactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt attagttata ctggtggtag cacatactat      180

gcagactccg tgaagggcag attcaccatc tccagagaga acgccaagaa cacactgtat      240

cttcaaatgg acagcctgag agctgaggac acggctgtct attactgtgc gagagttcta      300

tatagtggta gttattacta ctttgactac tggggccagg gagtcctggt caccgtctcc      360

tca                                                                    363


<210>  12
<211>  349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ101 light chain variable domain nucleotide sequence

<400>  12
cagtctgtgc tgactcagcc accctccctg tctgcatccc cgggagcatc ggccagactc       60

ccctgcaccc tgagcagtga cctcagtgtt ggtagtaaaa acatgtactg gtaccagcag      120

aagccaggga gcgctcccag gttattcctg tactactact ccgactcaga caagcagctg      180

ggacctgggg tccccaatcg agtctctggc tccaaggaga cctcaagtaa cacagcgttt      240

ttggtcatct ctgggctcca gcctgaggac gaggccgatt attactgtca ggtgtatgac      300

agtagtgcta atattgtgtt cggaagtggc accaagttga ccgtcctcg                  349


<210>  13
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ101 heavy chain variable domain amino acid sequence

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Tyr Thr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Leu Tyr Ser Gly Ser Tyr Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Val Leu Val Thr Val Ser Ser 
        115                 120     


<210>  14
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ101 light chain variable domain amino acid sequence

<400>  14

Gln Ser Val Leu Thr Gln Pro Pro Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Arg Leu Pro Cys Thr Leu Ser Ser Asp Leu Ser Val Gly Ser 
            20                  25                  30          


Lys Asn Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Arg Leu 
        35                  40                  45              


Phe Leu Tyr Tyr Tyr Ser Asp Ser Asp Lys Gln Leu Gly Pro Gly Val 
    50                  55                  60                  


Pro Asn Arg Val Ser Gly Ser Lys Glu Thr Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Val Ile Ser Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Gln Val Tyr Asp Ser Ser Ala Asn Ile Val Phe Gly Ser Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu Gly 
        115         


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ101 heavy chain CDR1 sequence

<400>  15

Gly Phe Ser Phe Ser Asp Tyr Tyr 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ101 heavy chain CDR2 sequence

<400>  16

Ile Ser Tyr Thr Gly Gly Ser Thr 
1               5               


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ101 heavy chain CDR3 sequence

<400>  17

Cys Ala Arg Val Leu Tyr Ser Gly Ser Tyr Tyr Tyr Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ101 light chain CDR1 sequence

<400>  18

Ser Asp Leu Ser Val Gly Ser Lys Asn 
1               5                   


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ101 light chain CDR2 sequence

<400>  19

Tyr Tyr Ser Asp Ser Asp Lys 
1               5           


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ101 light chain CDR3 sequence

<400>  20

Cys Gln Val Tyr Asp Ser Ser Ala Asn Ile Val Phe 
1               5                   10          


<210>  21
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ103 heavy chain variable domain nucleotide sequence

<400>  21
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcagagac cctgtccctc       60

acctgcgctg tttctggagg ctctatcagc ggtggttatg actggagctg gatccgccag      120

cccccaggga aggggctgga gtggattggg tatatctatg gtagtagtgg gagcaccaac      180

tacaacccgt ccctcaagaa tcgagtcacc atttcaaaag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgcg gacacggccg tgtattactg tgcgagaccc      300

gcgtattacg aggatgatta cggttactat tacaccaccc ccatctttga ctactggggc      360

cagggagtcc tggtcaccgt ctcctca                                          387


<210>  22
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ103 light chain variable domain nucleotide sequence

<400>  22
cagtctgtgc tgactcagcc accctcagcg tctggggctc ccgggcagag tgtcaccatc       60

tcttgctctg gaagcagctc caacattgga agtaattatg tatactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat tatagtaatc agcgaccctc aggggtccct      180

gaccgattct ctggctctaa gtctggcacc tcagcctccc tggccatcac tggtctccga      240

tctgaggatg aggctgatta ttactgtgca gcatgggata acagcctgag cagtgtgtta      300

ttcggaggag ggacccggct gaccgtccta ggt                                   333


<210>  23
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ103 heavy chain variable domain amino acid sequence

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Gly Gly 
            20                  25                  30          


Tyr Asp Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Tyr Gly Ser Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Pro Ala Tyr Tyr Glu Asp Asp Tyr Gly Tyr Tyr Tyr Thr 
            100                 105                 110         


Thr Pro Ile Phe Asp Tyr Trp Gly Gln Gly Val Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  24
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ103 light chain variable domain amino acid sequence

<400>  24

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asn Ser Leu 
                85                  90                  95      


Ser Ser Val Leu Phe Gly Gly Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ103 heavy chain CDR1 sequence

<400>  25

Gly Ser Ile Ser Gly Gly Tyr Asp 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ103 heavy chain CDR2 sequence

<400>  26

Ile Tyr Gly Ser Ser Gly Ser Thr 
1               5               


<210>  27
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ103 heavy chain CDR3 sequence

<400>  27

Cys Ala Arg Pro Ala Tyr Tyr Glu Asp Asp Tyr Gly Tyr Tyr Tyr Thr 
1               5                   10                  15      


Thr Pro Ile Phe Asp Tyr Trp 
            20              


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ103 light chain CDR1 sequence

<400>  28

Ser Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  29
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ103 light chain CDR2 sequence

<400>  29

Tyr Ser Asn 
1           


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ103 light chain CDR3 sequence

<400>  30

Cys Ala Ala Trp Asp Asn Ser Leu Ser Ser Val Leu Phe 
1               5                   10              


<210>  31
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ104 heavy chain variable domain nucleotide sequence

<400>  31
gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc ctggggggtc cctgagactc       60

tcctgcgcag cctccggatt caccttcagt gactactaca tggactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcacgt attagtaatg gtggtggtag cacatggtac      180

gcagactccg tgaagggcag attcaccatc tccagagaga acgccaagaa cacactgtat      240

cttcaaatga acagcctgag agctgaggac acggctgtct attactgtgc gagagagaga      300

tattgtagtg gtggtgtctg ctacgccggg acaaaatact ttgactactg gggccaggga      360

gtcctggtca ccgtctcctc a                                                381


<210>  32
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ104 light chain variable domain nucleotide sequence

<400>  32
cagcctgtgc tgactcagcc accctccctg tctgcatccc cgggagcatc ggccagactc       60

ccctgcaccc tgagcagtga cctcagtgtt ggtagtaaaa acatgtactg gtaccagcag      120

aagccaggga gcgctcccag gttattcctg tactactact ccgactcaga caagcagctg      180

ggacctgggg tccccaatcg agtctctggc tccaaggaga cctcaagtaa cacagcgttt      240

ttgctcatct ctgggctcca gcctgaggac gaggccgatt attactgtca ggtgtatgac      300

agtagtgcta attgggtatt cggcggaggg acccggctga ccgtcctagg t               351


<210>  33
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ104 heavy chain variable domain amino acid sequence

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Asn Gly Gly Gly Ser Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Tyr Cys Ser Gly Gly Val Cys Tyr Ala Gly Thr Lys 
            100                 105                 110         


Tyr Phe Asp Tyr Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  34
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ104 light chain variable domain amino acid sequence

<400>  34

Gln Pro Val Leu Thr Gln Pro Pro Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Arg Leu Pro Cys Thr Leu Ser Ser Asp Leu Ser Val Gly Ser 
            20                  25                  30          


Lys Asn Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Arg Leu 
        35                  40                  45              


Phe Leu Tyr Tyr Tyr Ser Asp Ser Asp Lys Gln Leu Gly Pro Gly Val 
    50                  55                  60                  


Pro Asn Arg Val Ser Gly Ser Lys Glu Thr Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Gln Val Tyr Asp Ser Ser Ala Asn Trp Val Phe Gly Gly Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Leu Gly 
        115         


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ104 heavy chain CDR1 sequence

<400>  35

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ104 heavy chain CDR2 sequence

<400>  36

Ile Ser Asn Gly Gly Gly Ser Thr 
1               5               


<210>  37
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ104 heavy chain CDR3 sequence

<400>  37

Cys Ala Arg Glu Arg Tyr Cys Ser Gly Gly Val Cys Tyr Ala Gly Thr 
1               5                   10                  15      


Lys Tyr Phe Asp Tyr Trp 
            20          


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ104 light chain CDR1 sequence

<400>  38

Ser Asp Leu Ser Val Gly Ser Lys Asn 
1               5                   


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ104 light chain CDR2 sequence

<400>  39

Tyr Tyr Ser Asp Ser Asp Lys 
1               5           


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ104 light chain CDR3 sequence

<400>  40

Cys Gln Val Tyr Asp Ser Ser Ala Asn Trp Val Phe 
1               5                   10          


<210>  41
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ107 heavy chain variable domain nucleotide sequence

<400>  41
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccgtcag      120

cccccaggga agggactgga gtatattggg tatatcagtg gtagtagtgg gagcacctac      180

tacaacccct ccctcaagag tcgagtcacc atttcaaaag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgcg gacacggccg tgtattactg tgcgagacga      300

gatcgtgtgg gcagctaccc ttattactac ggtttggatt cctggggcca aggggtcctg      360

gtcaccgtct cctca                                                       375


<210>  42
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ107 light chain variable domain nucleotide sequence

<400>  42
cagtctgtgc tgactcagcc accctccctg tctgcatccc cgggagcatc ggccagactc       60

ccctgcaccc tgagcagtga cctcagtgtt ggtagtaaaa acatgtactg gtaccagcag      120

aagccaggga gcgctcccag gttattcctg tactactact ccgactcaga caagcagctg      180

ggacctgggg tccccaatcg agtctctggc tccaaggaga cctcaagtaa cacagcgttt      240

ttgctcatct ctgggctcca gcctgaggac gaggccgatt attactgtca ggtgtatgac      300

ggtagtgcta atgatgtgtt cggaagtggc accaagttga ccgtcctcgg t               351


<210>  43
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ107 heavy chain variable domain amino acid sequence

<400>  43

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Tyr 
        35                  40                  45              


Ile Gly Tyr Ile Ser Gly Ser Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Asp Arg Val Gly Ser Tyr Pro Tyr Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  44
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ107 light chain variable domain amino acid sequence

<400>  44

Gln Ser Val Leu Thr Gln Pro Pro Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Arg Leu Pro Cys Thr Leu Ser Ser Asp Leu Ser Val Gly Ser 
            20                  25                  30          


Lys Asn Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Arg Leu 
        35                  40                  45              


Phe Leu Tyr Tyr Tyr Ser Asp Ser Asp Lys Gln Leu Gly Pro Gly Val 
    50                  55                  60                  


Pro Asn Arg Val Ser Gly Ser Lys Glu Thr Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Gln Val Tyr Asp Gly Ser Ala Asn Asp Val Phe Gly Ser Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu Gly 
        115         


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ107 heavy chain CDR1 sequence

<400>  45

Tyr Ser Ile Ser Ser Gly Tyr Tyr 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ107 heavy chain CDR2 sequence

<400>  46

Ile Ser Gly Ser Ser Gly Ser Thr 
1               5               


<210>  47
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ107 heavy chain CDR3 sequence

<400>  47

Cys Ala Arg Arg Asp Arg Val Gly Ser Tyr Pro Tyr Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ser Trp 
            


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ107 light chain CDR1 sequence

<400>  48

Ser Asp Leu Ser Val Gly Ser Lys Asn 
1               5                   


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ107 light chain CDR2 sequence

<400>  49

Tyr Tyr Ser Asp Ser Asp Lys 
1               5           


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ107 light chain CDR3 sequence

<400>  50

Cys Gln Val Tyr Asp Gly Ser Ala Asn Asp Val Phe 
1               5                   10          


<210>  51
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ119 heavy chain variable domain nucleotide sequence

<400>  51
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaggc ccggggagtc tctgaagatc       60

tcctgtaaga cttctggata cagctttacc agctactgga tcagctgggt gcgccagatg      120

cccggaaaag gcctggagtg gatgggggcg attgatccta gtgattctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac tccgccacgt attactgtgc gaaagagggg      300

atagcggcac ggtcattgga tgtctggggc cggggagttc tggtcaccgt ctcctca         357


<210>  52
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ119 light chain variable domain nucleotide sequence

<400>  52
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacagac ggccaggatc       60

acctgctctg gagatgcatt gccaaaaaaa tatgcttatt ggttccagca gaagccaggc      120

cagtcccctg tgctgatcat ctatgaggac agcaaacggc cctctgggat ccctgagaga      180

ttctctggct ccagctcagg gacagtggcc accttgacta tcagtggggc ccaggtggag      240

gatgaagctg actactactg ttactcaaca gatagcagtg gttaccatgg cttattcgga      300

ggagggaccc ggctgaccgt cctaggtcag                                       330


<210>  53
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ119 heavy chain variable domain amino acid sequence

<400>  53

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Asp Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Ser Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Ile Ala Ala Arg Ser Leu Asp Val Trp Gly Arg Gly 
            100                 105                 110         


Val Leu Val Thr Val Ser Ser 
        115                 


<210>  54
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ119 light chain variable domain amino acid sequence

<400>  54

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Ile Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Val Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Tyr His 
                85                  90                  95      


Gly Leu Phe Gly Gly Gly Thr Arg Leu Thr Val Leu Gly Gln 
            100                 105                 110 


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ119 heavy chain CDR1 sequence

<400>  55

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ119 heavy chain CDR2 sequence

<400>  56

Ile Asp Pro Ser Asp Ser Asp Thr 
1               5               


<210>  57
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ119 heavy chain CDR3 sequence

<400>  57

Cys Ala Lys Glu Gly Ile Ala Ala Arg Ser Leu Asp Val Trp 
1               5                   10                  


<210>  58
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ119 light chain CDR1 sequence

<400>  58

Ala Leu Pro Lys Lys Tyr 
1               5       


<210>  59
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ119 light chain CDR2 sequence

<400>  59

Glu Asp Ser 
1           


<210>  60
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ119 light chain CDR3 sequence

<400>  60

Cys Tyr Ser Thr Asp Ser Ser Gly Tyr His Gly Leu Phe 
1               5                   10              


<210>  61
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ121 heavy chain variable domain nucleotide sequence

<400>  61
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccgtcag      120

cccccaggga agggactgga gtatattggg tatatcagtg gtagtagtgg gagcacctac      180

tacaacccct ccctcaagag tcgagtcacc atttcaaaag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgcg gacacggccg tgtattactg tgcgagaggg      300

aattactata gtggtagtta ttacttgttc tggggccagg gagtcctggt caccgtctcc      360

tca                                                                    363


<210>  62
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ121 light chain variable domain nucleotide sequence

<400>  62
tcctatgagc tgactcagcc accctcggtg tcagtgtccc caggacagac ggccaggatc       60

acctgtgggg gagacaacct tggaagtaaa tatgtgcact ggtaccagca gaagccagcg      120

caggcccctg tgctggtcat ctattatgat agtgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaaatcagg gaacaccgcc accctgacca tcagcggggt cgaggccggg      240

gatgaggctg actattactg tcaggtgtgg gacagtagta gtgatcattg ggtattcggc      300

ggagggaccc ggctgaccgt cctaggtcag gtctcctca                             339


<210>  63
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ121 heavy chain variable domain amino acid sequence

<400>  63

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Tyr 
        35                  40                  45              


Ile Gly Tyr Ile Ser Gly Ser Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Asn Tyr Tyr Ser Gly Ser Tyr Tyr Leu Phe Trp Gly 
            100                 105                 110         


Gln Gly Val Leu Val Thr Val Ser Ser 
        115                 120     


<210>  64
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ121 light chain variable domain amino acid sequence

<400>  64

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Leu Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Ala Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu Gly Gln 
            100                 105                 110 


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ121 heavy chain CDR1 sequence

<400>  65

Tyr Ser Ile Ser Ser Gly Tyr Tyr 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ121 heavy chain CDR2 sequence

<400>  66

Ile Ser Gly Ser Ser Gly Ser Thr 
1               5               


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ121 heavy chain CDR3 sequence

<400>  67

Cys Ala Arg Gly Asn Tyr Tyr Ser Gly Ser Tyr Tyr Leu Phe Trp 
1               5                   10                  15  


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ121 light chain CDR1 sequence

<400>  68

Asn Leu Gly Ser Lys Tyr 
1               5       


<210>  69
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ121 light chain CDR2 sequence

<400>  69

Tyr Asp Ser 
1           


<210>  70
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ121 light chain CDR3 sequence

<400>  70

Cys Gln Val Trp Asp Ser Ser Ser Asp His Trp Val Phe 
1               5                   10              


<210>  71
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ123 heavy chain variable domain nucleotide sequence

<400>  71
cagctggtgc agtctggagc agaggtgaaa aggcccgggg aatctctgag gatctcctgt       60

aagacttctg gatacagctt taccagctac tggatcagct gggtgcgcca gatgcccggg      120

aaaggcctgg agtggatggg gatgatctat cctggtgatt ctgataccag atacagcccg      180

tccttccaag gccaggtcac catctcagcc gacaagtcca tcagcaccgc ctacctgcag      240

tggagcagcc tgaaggcctc ggacaccgcc acgtattact gtgcgaaagt ggatagcagc      300

ggctggacca actactttga ctactggggc cagggagtcc tggtcaccgt ctcctca         357


<210>  72
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ123 light chain variable domain nucleotide sequence

<400>  72
cagtctgccc tgactcagcc tccctcagtg tccaagtctc ttggacagtc ggtcaccatc       60

tcctgcactg gaaccagcag tgacattggt ggttataatg gcgtctcctg gtaccagcag      120

cactcaggga cagcccccag actcctgatt tatgatgtca gtaagcggcc ctcaggggtc      180

tctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc tgctcatata ggagtggaag cacttacatc      300

ttcggtgctg ggacccggct caccgtccta ggtcag                                336


<210>  73
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ123 heavy chain variable domain amino acid sequence

<400>  73

Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Glu Ser Leu 
1               5                   10                  15      


Arg Ile Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile 
            20                  25                  30          


Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Met 
        35                  40                  45              


Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly 
    50                  55                  60                  


Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
65                  70                  75                  80  


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Thr Tyr Tyr Cys Ala Lys 
                85                  90                  95      


Val Asp Ser Ser Gly Trp Thr Asn Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Val Leu Val Thr Val Ser Ser 
        115                 


<210>  74
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ123 light chain variable domain amino acid sequence

<400>  74

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Lys Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr 
            20                  25                  30          


Asn Gly Val Ser Trp Tyr Gln Gln His Ser Gly Thr Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Arg Ser Gly 
                85                  90                  95      


Ser Thr Tyr Ile Phe Gly Ala Gly Thr Arg Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ123 heavy chain CDR1 sequence

<400>  75

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ123 heavy chain CDR2 sequence

<400>  76

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  77
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ123 heavy chain CDR3 sequence

<400>  77

Cys Ala Lys Val Asp Ser Ser Gly Trp Thr Asn Tyr Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ123 light chain CDR1 sequence

<400>  78

Ser Ser Asp Ile Gly Gly Tyr Asn Gly 
1               5                   


<210>  79
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ123 light chain CDR2 sequence

<400>  79

Asp Val Ser 
1           


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ123 light chain CDR3 sequence

<400>  80

Cys Cys Ser Tyr Arg Ser Gly Ser Thr Tyr Ile Phe 
1               5                   10          


<210>  81
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ124 heavy chain variable domain nucleotide sequence

<400>  81
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcgctg tctctggtga ctccatcagc agtggttact actggggctg gatccgtcag      120

tccccaggga ggggactgga gtcttttggg tttattagtg gcagtggtgg gaccacctac      180

tacaacccct ccctcaagac tcgagtcacc atttcaaaag acacgtccaa gaaccagttc      240

tccctgaaac tgagttctgt gaccgccgcg gacacggccg tatattactg tgcgagactc      300

ggacaccccc ggggtatagc ggcaggtgga gttgactact ggggccaggg agtcctggtc      360

accgtctcct ca                                                          372


<210>  82
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ124 light chain variable domain nucleotide sequence

<400>  82
cagtctgccc tgactcagcc accctccctg tctgcatccc cgggagcatc ggccagactc       60

ccctgcaccc tgagcagtga cttcagtgtt ggtaataaaa acatgtactg gtaccagcag      120

aagccaggga gcgctcccgg tttattccta tacttctact ccgactcaga caatcagctg      180

ggacctgggg tccccaatcg agtctctggc tccaaggagg cctcaagcaa cacagcgttt      240

ttgctcatct ctggcctcca gcctgaggac gaggccgatt attactgtca ggtatatgac      300

agagctgcta atatcctatt cggaggaggg acccggctga ccgtcctagg t               351


<210>  83
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ124 heavy chain variable domain amino acid sequence

<400>  83

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu Ser 
        35                  40                  45              


Phe Gly Phe Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Thr Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Gly His Pro Arg Gly Ile Ala Ala Gly Gly Val Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  84
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ124 light chain variable domain amino acid sequence

<400>  84

Gln Ser Ala Leu Thr Gln Pro Pro Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Arg Leu Pro Cys Thr Leu Ser Ser Asp Phe Ser Val Gly Asn 
            20                  25                  30          


Lys Asn Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Gly Leu 
        35                  40                  45              


Phe Leu Tyr Phe Tyr Ser Asp Ser Asp Asn Gln Leu Gly Pro Gly Val 
    50                  55                  60                  


Pro Asn Arg Val Ser Gly Ser Lys Glu Ala Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Gln Val Tyr Asp Arg Ala Ala Asn Ile Leu Phe Gly Gly Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Leu Gly 
        115         


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ124 heavy chain CDR1 sequence

<400>  85

Asp Ser Ile Ser Ser Gly Tyr Tyr 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ124 heavy chain CDR2 sequence

<400>  86

Ile Ser Gly Ser Gly Gly Thr Thr 
1               5               


<210>  87
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ124 heavy chain CDR3 sequence

<400>  87

Cys Ala Arg Leu Gly His Pro Arg Gly Ile Ala Ala Gly Gly Val Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ124 light chain CDR1 sequence

<400>  88

Ser Asp Phe Ser Val Gly Asn Lys Asn 
1               5                   


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ124 light chain CDR2 sequence

<400>  89

Phe Tyr Ser Asp Ser Asp Asn 
1               5           


<210>  90
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ124 light chain CDR3 sequence

<400>  90

Cys Gln Val Tyr Asp Arg Ala Ala Asn Ile Leu Phe 
1               5                   10          


<210>  91
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ133 heavy chain variable domain nucleotide sequence

<400>  91
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggcgggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctgggt ccgccaggct      120

ccagggaagg ggccggagtg ggtaggtttc attagaaaca aagctaacgg tgggacagca      180

gaatacgccg cgtctgtgaa aggcagattc accgtctcaa gagatgattc caaaagcatt      240

gccagtctgc aaatgaacag cctgaaaacc gaggacacgg ccgtgtatta ctgtgctaaa      300

cattactgta ctggtagtgg ttgctacggg gcgggtttgg attcctgggg ccaaggggtc      360

gtcgtcaccg tctcctca                                                    378


<210>  92
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ133 light chain variable domain nucleotide sequence

<400>  92
cagtctgtcc tgactcagcc tccctcagtg tccaagtctc ttggacagtc ggtcaccatc       60

tcctgcactg gaaccagcag tgacattggt ggttctaatg acgtctcctg gtaccaacag      120

cacccaggca cagcccccag actcctgatt tataatgtca gtaagcggcc ctcaggggtc      180

tctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc tgctcatata ggagtggaag cactttattc      300

ggcggaggga cccggctgac cgtcctaggt cag                                   333


<210>  93
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ133 heavy chain variable domain amino acid sequence

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Gly Thr Ala Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Ser Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys His Tyr Cys Thr Gly Ser Gly Cys Tyr Gly Ala Gly 
            100                 105                 110         


Leu Asp Ser Trp Gly Gln Gly Val Val Val Thr Val Ser Ser 
        115                 120                 125     


<210>  94
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ133 light chain variable domain amino acid sequence

<400>  94

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Lys Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Ser 
            20                  25                  30          


Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Thr Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Asn Val Ser Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Arg Ser Gly 
                85                  90                  95      


Ser Thr Leu Phe Gly Gly Gly Thr Arg Leu Thr Val Leu Gly Gln 
            100                 105                 110     


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ133 heavy chain CDR1 sequence

<400>  95

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ133 heavy chain CDR2 sequence

<400>  96

Ile Arg Asn Lys Ala Asn Gly Gly Thr Ala 
1               5                   10  


<210>  97
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ133 heavy chain CDR3 sequence

<400>  97

Cys Ala Lys His Tyr Cys Thr Gly Ser Gly Cys Tyr Gly Ala Gly Leu 
1               5                   10                  15      


Asp Ser Trp 
            


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ133 light chain CDR1 sequence

<400>  98

Ser Ser Asp Ile Gly Gly Ser Asn Asp 
1               5                   


<210>  99
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ133 light chain CDR2 sequence

<400>  99

Asn Val Ser 
1           


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ133 light chain CDR3 sequence

<400>  100

Cys Cys Ser Tyr Arg Ser Gly Ser Thr Leu Phe 
1               5                   10      


<210>  101
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ134 heavy chain variable domain nucleotide sequence

<400>  101
gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc ctggggggtc cctgagactc       60

tcctgcgcag cctccggatt caccttcagt gactactaca tggactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcacgt attagtaatg gtggtggtag cacatggtac      180

gcagactccg tgaagggcag attcaccatc tccagagaga acgccaagaa cacactgtat      240

cttcaaatga acagcctgag agctgaggac acggctgtct attactgtgc gagagggcct      300

gaatattgta gtagtactta ctgctcctcg gcatactgta ctggtagtgg ttgctacgtt      360

gactacggtt tggattcctg gggccaaggg gtcgtcgtca ccgtctcctc a               411


<210>  102
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rhMZ134 light chain variable domain nucleotide sequence

<400>  102
tcctatgagc tgactcagcc accctcggtg tcggtgtccc caggacagat ggccaggatc       60

acctgtgggg gagacaacat tggaagtaaa aatgtgcagt ggtaccagca gaagccagcg      120

caggcccctg tgctggtcat ctatgctgat agcgaacggc cctcagggat ccctgagcga      180

ttctctggct ccaactcagg gaacacggcc accctgacca tcagcggggt cgaggccggg      240

gatgaggctg actattactg tcaggtgtgg gatagtagta gtgatcatgt gttattcgga      300

ggagggaccc ggctgaccgt cctag                                            325


<210>  103
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ134 heavy chain variable domain amino acid sequence

<400>  103

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Asn Gly Gly Gly Ser Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Glu Tyr Cys Ser Ser Thr Tyr Cys Ser Ser Ala Tyr 
            100                 105                 110         


Cys Thr Gly Ser Gly Cys Tyr Val Asp Tyr Gly Leu Asp Ser Trp Gly 
        115                 120                 125             


Gln Gly Val Val Val Thr Val Ser Ser 
    130                 135         


<210>  104
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ134 light chain variable domain amino acid sequence

<400>  104

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Met Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


Gln Trp Tyr Gln Gln Lys Pro Ala Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Ala Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Val Leu Phe Gly Gly Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 


<210>  105
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ134 heavy chain CDR1 sequence

<400>  105

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ134 heavy chain CDR2 sequence

<400>  106

Ile Ser Asn Gly Gly Gly Ser Thr 
1               5               


<210>  107
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ134 heavy chain CDR3 sequence

<400>  107

Cys Ala Arg Gly Pro Glu Tyr Cys Ser Ser Thr Tyr Cys Ser Ser Ala 
1               5                   10                  15      


Tyr Cys Thr Gly Ser Gly Cys Tyr Val Asp Tyr Gly Leu Asp Ser Trp 
            20                  25                  30          


<210>  108
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ134 light chain CDR1 sequence

<400>  108

Asn Ile Gly Ser Lys Asn 
1               5       


<210>  109
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ134 light chain CDR2 sequence

<400>  109

Ala Asp Ser 
1           


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhMZ134 light chain CDR3 sequence

<400>  110

Gln Val Trp Asp Ser Ser Ser Asp His Val Leu 
1               5                   10      


<210>  111
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ4 heavy chain variable domain nucleotide sequence

<400>  111
caggtgcatc tgcaggagtc gggcccagga ctggtgaggc cttcggagac cctgtccctc       60

acctgcactg tctctgatgg atccatcagc agttattatt ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtct atctattaca ctgggagtac caactacaac      180

ccctccctca agagtcgagt caccatgtca gtagacacgt ccaagaacca gttctccctg      240

aggctgaatt ctgtgaccgc cgcagacacg gccatgtatt actgtgcggg acttgaccgg      300

tatagctgga acgaaggagg tgaccactgg ggccagggaa tcctggtcag cgtctcctca      360


<210>  112
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ4 light chain variable domain nucleotide sequence

<400>  112
cagcctgtgc tgactcagcc gccctcagcg tctgggaccc ccgggcagag ggtctccatc       60

tcttgttctg gcagcagatc caacctcgga aagaatactg tgaactggta ccagcaactc      120

ccaggaacgg cccccaaact cctcatctat aatcatagtc ggcggccctc aggggtccct      180

gaacgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta tttctgtgca gcatgggatg acagtctgaa tggcctttat      300

gtcttcggaa ctgggaccaa ggtcaccgtc ctacgt                                336


<210>  113
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ4 heavy chain variable domain amino acid sequence

<400>  113

Gln Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Asp Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Leu Asp Arg Tyr Ser Trp Asn Glu Gly Gly Asp His Trp Gly Gln 
            100                 105                 110         


Gly Ile Leu Val Ser Val Ser Ser 
        115                 120 


<210>  114
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ4 light chain variable domain amino acid sequence

<400>  114

Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Ser Cys Ser Gly Ser Arg Ser Asn Leu Gly Lys Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asn His Ser Arg Arg Pro Ser Gly Val Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Phe Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Arg 
            100                 105                 110         


<210>  115
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ4 heavy chain CDR1 sequence

<400>  115

Asp Gly Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ4 heavy chain CDR2 sequence

<400>  116

Ile Tyr Tyr Thr Gly Ser Thr 
1               5           


<210>  117
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ4 heavy chain CDR3 sequence

<400>  117

Cys Ala Gly Leu Asp Arg Tyr Ser Trp Asn Glu Gly Gly Asp His Trp 
1               5                   10                  15      


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ4 light chain CDR1 sequence

<400>  118

Arg Ser Asn Leu Gly Lys Asn Thr 
1               5               


<210>  119
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ4 light chain CDR2 sequence

<400>  119

Asn His Ser 
1           


<210>  120
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ4 light chain CDR3 sequence

<400>  120

Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Tyr Val Phe 
1               5                   10                  


<210>  121
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ1 heavy chain variable domain nucleotide sequence

<400>  121
caggtgcagc tgcaggagtc gggcccagga ctggtgaagt cttcggagac cctgtccctc       60

agttgcactg tctctggtgc ctccatcagt aatttctatt ggagttgggt ccggcagccc      120

ccagggaagg gactggaatg gatgggatcc atatattaca ctggaactat cacctacaac      180

ccctccctca agagtcgact caccatgtca gtggacacgt ccaagaacca gttctccctg      240

aagttgaact ctgtgaccgc cgcagacacg gccgtctatt cctgtgcggg acttgaccgg      300

tttaactgga acgacgaagg tgactgctgg ggccagggca ccctggtcac cgtcttctca      360


<210>  122
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ1 light chain variable domain nucleotide sequence

<400>  122

Cys Ala Gly Thr Cys Thr Gly Thr Gly Cys Thr Gly Ala Cys Thr Cys 
1               5                   10                  15      


Ala Gly Cys Cys Ala Cys Cys Cys Thr Cys Ala Gly Cys Gly Thr Cys 
            20                  25                  30          


Thr Gly Gly Gly Ala Cys Cys Cys Cys Cys Gly Gly Gly Cys Ala Gly 
        35                  40                  45              


Ala Gly Gly Gly Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys Thr Thr 
    50                  55                  60                  


Gly Thr Thr Cys Thr Gly Gly Ala Ala Gly Cys Ala Gly Gly Thr Cys 
65                  70                  75                  80  


Cys Ala Ala Cys Cys Thr Cys Gly Gly Ala Ala Gly Gly Ala Ala Thr 
                85                  90                  95      


Ala Cys Thr Gly Thr Ala Ala Ala Cys Thr Gly Gly Thr Ala Thr Cys 
            100                 105                 110         


Ala Gly Cys Ala Gly Cys Thr Cys Cys Cys Ala Gly Gly Ala Gly Thr 
        115                 120                 125             


Gly Gly Cys Cys Cys Cys Cys Ala Ala Ala Cys Thr Cys Cys Thr Cys 
    130                 135                 140                 


Ala Thr Cys Thr Ala Thr Ala Gly Thr Ala Ala Thr Ala Ala Thr Cys 
145                 150                 155                 160 


Gly Gly Cys Gly Gly Cys Cys Cys Thr Cys Ala Gly Gly Ala Gly Thr 
                165                 170                 175     


Cys Cys Cys Thr Gly Ala Thr Cys Gly Ala Thr Thr Thr Thr Cys Thr 
            180                 185                 190         


Gly Gly Cys Thr Cys Cys Ala Ala Gly Thr Cys Thr Gly Ala Cys Ala 
        195                 200                 205             


Cys Cys Thr Cys Ala Gly Cys Cys Thr Cys Cys Cys Thr Gly Gly Cys 
    210                 215                 220                 


Cys Ala Thr Cys Ala Gly Cys Gly Gly Gly Cys Thr Cys Cys Ala Gly 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Gly Ala Thr Gly Ala Gly Gly Cys Thr Gly 
                245                 250                 255     


Ala Thr Thr Ala Thr Thr Thr Cys Thr Gly Thr Gly Cys Ala Gly Cys 
            260                 265                 270         


Ala Thr Gly Gly Gly Ala Thr Gly Ala Cys Ala Gly Cys Cys Thr Gly 
        275                 280                 285             


Ala Ala Thr Gly Gly Cys Cys Thr Thr Thr Ala Thr Gly Thr Cys Thr 
    290                 295                 300                 


Thr Cys Gly Gly Ala Ala Cys Thr Gly Gly Gly Ala Cys Cys Ala Ala 
305                 310                 315                 320 


Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Cys Thr Ala Gly Gly Thr 
                325                 330                 335     


<210>  123
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ1 heavy chain variable domain amino acid sequence

<400>  123

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Ser Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Thr Val Ser Gly Ala Ser Ile Ser Asn Phe 
            20                  25                  30          


Tyr Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Tyr Tyr Thr Gly Thr Ile Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Ser Cys Ala 
                85                  90                  95      


Gly Leu Asp Arg Phe Asn Trp Asn Asp Glu Gly Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Phe Ser 
        115                 120 


<210>  124
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ1 light chain variable domain amino acid sequence

<400>  124

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Leu Gly Arg Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Val Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Asp Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Phe Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


<210>  125
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ1 heavy chain CDR1 sequence

<400>  125

Gly Ala Ser Ile Ser Asn Phe Tyr 
1               5               


<210>  126
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ1 heavy chain CDR2 sequence

<400>  126

Ile Tyr Tyr Thr Gly Thr Ile 
1               5           


<210>  127
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ1 heavy chain CDR3 sequence

<400>  127

Cys Ala Gly Leu Asp Arg Phe Asn Trp Asn Asp Glu Gly Asp Cys Trp 
1               5                   10                  15      


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ1 light chain CDR1 sequence

<400>  128

Arg Ser Asn Leu Gly Arg Asn Thr 
1               5               


<210>  129
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ1 light chain CDR2 sequence

<400>  129

Ser Asn Asn 
1           


<210>  130
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ1 light chain CDR3 sequence

<400>  130

Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Tyr Val Phe 
1               5                   10                  


<210>  131
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ24 heavy chain variable domain nucleotide sequence

<400>  131
caggtgcagc tgcaggagtc gggcccagga ctggtaaagt cttcggagac cctgtccctc       60

agctgcactg tctctggtgc ctccatcagt agttattatt ggagctgggt ccgacagtcc      120

ccagggaagg gactggagtg gatgggatct atatattaca ctggaaccac cacctacaac      180

ccctccctca agagtcgact caccatatca gtggacacgt ccaagaacca gttctccctg      240

aagctgaact ctgtgaccgc cgcagacacg gccgtatatt cctgtgcggg acttgaccgg      300

tttaactgga acgacgaagg tgactgctgg ggccagggca ccctggtcac cgtcttctca      360


<210>  132
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ24 light chain variable domain nucleotide sequence

<400>  132
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcaggtc caacctcgga aggaatactg taaactggta ccagcagctc      120

ccaggagtgg cccccaaact cctcatctat agtaatagtc ggcggccctc aggagtccct      180

gaccgatttt ctggctccaa gtctgacacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggcctttat      300

gtctttggaa ctgggaccag tgtcaccgtc ctaggt                                336


<210>  133
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ24 heavy chain variable domain amino acid sequence

<400>  133

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Ser Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Tyr Tyr Thr Gly Thr Thr Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Ser Cys Ala 
                85                  90                  95      


Gly Leu Asp Arg Phe Asn Trp Asn Asp Glu Gly Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Phe Ser 
        115                 120 


<210>  134
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ24 light chain variable domain amino acid sequence

<400>  134

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Leu Gly Arg Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Val Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Ser Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Asp Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Leu Tyr Val Phe Gly Thr Gly Thr Ser Val Thr Val Leu Gly 
            100                 105                 110         


<210>  135
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ24 heavy chain CDR1 sequence

<400>  135

Gly Ala Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ24 heavy chain CDR2 sequence

<400>  136

Ile Tyr Tyr Thr Gly Thr Thr 
1               5           


<210>  137
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ24 heavy chain CDR3 sequence

<400>  137

Cys Ala Gly Leu Asp Arg Phe Asn Trp Asn Asp Glu Gly Asp Cys Trp 
1               5                   10                  15      


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ24 light chain CDR1 sequence

<400>  138

Arg Ser Asn Leu Gly Arg Asn Thr 
1               5               


<210>  139
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ24 light chain CDR2 sequence

<400>  139

Ser Asn Ser 
1           


<210>  140
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ24 light chain CDR3 sequence

<400>  140

Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Tyr Val Phe 
1               5                   10                  


<210>  141
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ20 heavy chain variable domain nucleotide sequence

<400>  141
gaagtgcagg tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt cacttctaca tgacctggat ccgccaggct      120

ccagggaagg gcctggagtc tatttcatac attggaggta ctggatctcc cacctactac      180

gctgactctg tggtgggccg tttcaccatc tccagggaca acgccaagaa ctcagtgtat      240

ctggaaatga acagcctgag agccgaagac acggccatat attattgtgt gagggctggt      300

ggggcgagga ttgagaactg gggccaggga accctggtca tcgtctcgtc a               351


<210>  142
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ20 light chain variable domain nucleotide sequence

<400>  142
gacattgtga tgacccagtc tccatcctcc ctgtctgcat ctgtggggga cagagtcacc       60

atcacttgcc aggcgagtca cgacattaac atctatttaa attggtatca acagagacca      120

gggaaagccc ctaaactcct gatctacgat gcatccagat tagagacagg ggtcccatca      180

aggttcagtg ggactggatc tgggacagat ttcactttca ccatcagcaa cctgcagcct      240

gaagattttg caacatattt ctgtcaacat tattatactc tcccgcggac gttcggccaa      300

gggaccaagg ttgacatcaa acga                                             324


<210>  143
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ20 heavy chain variable domain amino acid sequence

<400>  143

Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Phe 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Ser Tyr Ile Gly Gly Thr Gly Ser Pro Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Val Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ala Gly Gly Ala Arg Ile Glu Asn Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Ile Val Ser Ser 
        115         


<210>  144
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ20 light chain variable domain amino acid sequence

<400>  144

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp Ile Asn Ile Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Arg Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln His Tyr Tyr Thr Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg 
            100                 105             


<210>  145
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ20 heavy chain CDR1 sequence

<400>  145

Gly Phe Thr Phe Ser His Phe Tyr 
1               5               


<210>  146
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ20 heavy chain CDR2 sequence

<400>  146

Ile Gly Gly Thr Gly Ser Pro Thr 
1               5               


<210>  147
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ20 heavy chain CDR3 sequence

<400>  147

Cys Val Arg Ala Gly Gly Ala Arg Ile Glu Asn Trp 
1               5                   10          


<210>  148
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ20 light chain CDR1 sequence

<400>  148

His Asp Ile Asn Ile Tyr 
1               5       


<210>  149
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ20 light chain CDR2 sequence

<400>  149

Asp Ala Ser 
1           


<210>  150
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ20 light chain CDR3 sequence

<400>  150

Cys Gln His Tyr Tyr Thr Leu Pro Arg Thr Phe 
1               5                   10      


<210>  151
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ54 heavy chain variable domain nucleotide sequence

<400>  151
gaagtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggggggtc cctgagactc       60

tcctgttcag cctctggatt caactttcgt gacttctaca tgggctgggt ccgccaggct      120

ccaggaaagg gtctacagtg ggtttcacac attggtgata gtggtggtgc catatattac      180

acagactctg tggagggccg attctccatc tccagggaca acgccaagaa ctccctttat      240

ctccaaatga acagcctgag agtcgaggac acggctatct attactgtgt gtgtgcgggg      300

gggggccgga ctgactactg gggccaggga accctagtca ccgtctcctc a               351


<210>  152
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ54 light chain variable domain nucleotide sequence

<400>  152
gacattgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgactca ggacattaac atatatttaa attggtatca acagaagcca      120

gggcaggccc cgaaactcct catctacgat gcatccaggt tggagacagg ggtcccatca      180

aggttcagtg gacgtggatc tgggacagat tttaccttca ccatcagcag cctgcagcct      240

gaagatttcg gaacatatta ttgtcaacac tattatactg tccctcgaac gttcggccaa      300

gggaccaagg tggaaagcag acga                                             324


<210>  153
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ54 heavy chain variable domain amino acid sequence

<400>  153

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asn Phe Arg Asp Phe 
            20                  25                  30          


Tyr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ser His Ile Gly Asp Ser Gly Gly Ala Ile Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Cys Ala Gly Gly Gly Arg Thr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  154
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ54 light chain variable domain amino acid sequence

<400>  154

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Thr Gln Asp Ile Asn Ile Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Arg Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Tyr Tyr Thr Val Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ser Arg Arg 
            100                 105             


<210>  155
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ54 heavy chain CDR1 sequence

<400>  155

Gly Phe Asn Phe Arg Asp Phe Tyr 
1               5               


<210>  156
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ54 heavy chain CDR2 sequence

<400>  156

Ile Gly Asp Ser Gly Gly Ala Ile 
1               5               


<210>  157
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ54 heavy chain CDR3 sequence

<400>  157

Cys Val Cys Ala Gly Gly Gly Arg Thr Asp Tyr Trp 
1               5                   10          


<210>  158
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ54 light chain CDR1 sequence

<400>  158

Gln Asp Ile Asn Ile Tyr 
1               5       


<210>  159
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ54 light chain CDR2 sequence

<400>  159

Asp Ala Ser 
1           


<210>  160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ54 light chain CDR3 sequence

<400>  160

Cys Gln His Tyr Tyr Thr Val Pro Arg Thr Phe 
1               5                   10      


<210>  161
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ56 heavy chain variable domain nucleotide sequence

<400>  161
gaagtgcagc tggtggagtc tgggggagac ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aactatgcta tgcactgggt ccgccaggcg      120

ccagggaagg gactggagtc tgtttcagct attggtagta atggggatag tatattttat      180

gcaagctctg tgaagggcag attcaccatc tccagagaca attccaagaa cacgctgtat      240

cttcaaatgg gcagcctgag agctgacgac atggctgtgt atttctgtgc gagaggctgg      300

tattactatg atagtcgtgc ttattggtac ttcgatctct ggggccgtgg caccctggtc      360

actgtctcct ca                                                          372


<210>  162
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ56 light chain variable domain nucleotide sequence

<400>  162
cagyctgtgc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg ggaccaccag tgacgttgat gattataatc atgtctcctg gtaccaacaa      120

tatccaggca aagcccccag agtcatgctt tatgatgtca ctaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctccgggctc      240

caatctgagg atgaggctga ttattactgc tgctcatttg cagacagtca cgcgatattc      300

ggtggaggga ccaaggtgac cgtcctaggt                                       330


<210>  163
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ56 heavy chain variable domain amino acid sequence

<400>  163

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              


Ser Ala Ile Gly Ser Asn Gly Asp Ser Ile Phe Tyr Ala Ser Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Ser Leu Arg Ala Asp Asp Met Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Trp Tyr Tyr Tyr Asp Ser Arg Ala Tyr Trp Tyr Phe Asp 
            100                 105                 110         


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  164
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ56 light chain variable domain amino acid sequence

<400>  164

Gln Pro Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Thr Ser Asp Val Asp Asp Tyr 
            20                  25                  30          


Asn His Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Arg Val 
        35                  40                  45              


Met Leu Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Phe Ala Asp Ser 
                85                  90                  95      


His Ala Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110 


<210>  165
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ56 heavy chain CDR1 sequence

<400>  165

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  166
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ56 heavy chain CDR2 sequence

<400>  166

Ile Gly Ser Asn Gly Asp Ser Ile 
1               5               


<210>  167
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ56 heavy chain CDR3 sequence

<400>  167

Cys Ala Arg Gly Trp Tyr Tyr Tyr Asp Ser Arg Ala Tyr Trp Tyr Phe 
1               5                   10                  15      


Asp Leu Trp 
            


<210>  168
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ58 light chain CDR1 sequence

<400>  168

Thr Ser Asp Val Asp Asp Tyr Asn His 
1               5                   


<210>  169
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ56 light chain CDR2 sequence

<400>  169

Asp Val Thr 
1           


<210>  170
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ56 light chain CDR3 sequence

<400>  170

Cys Cys Ser Phe Ala Asp Ser His Ala Ile Phe 
1               5                   10      


<210>  171
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ22 heavy chain variable domain nucleotide sequence

<400>  171
cagctgcatc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccttcagc agttactact ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtct atctattaca ctgggagtac caactacaac      180

ccctccctca agagtcgagt caccatatca gttgacgcgt ccaagaacca gttctccctg      240

aggctgaact ctgtgaccgc cgcagacacg gccatatatt actgtgcggg acttgaccgt      300

tatgcctgga acgacggagg tgaccactgg ggccagggaa ccctggtcag cgtcccctca      360


<210>  172
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ22 light chain variable domain nucleotide sequence

<400>  172
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtctccatt       60

tcttgttctg gaagcagctc caacctcgga aggaatactc tgcactggta ccagcaactc      120

ccaggaacgg cccccaaact cctcatctat aataatagtc ggcggccctc aggggtccct      180

gaacgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta tttctgtgca tcatgggatg acagcctgaa cggcctttat      300

gtcttcggaa ctggaccaag gtcacct                                          327


<210>  173
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ22 heavy chain variable domain amino acid sequence

<400>  173

Gln Leu His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Ala Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Leu Asp Arg Tyr Ala Trp Asn Asp Gly Gly Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Ser Val Pro Ser 
        115                 120 


<210>  174
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ22 light chain variable domain amino acid sequence

<400>  174

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Ser Cys Ser Gly Ser Ser Ser Asn Leu Gly Arg Asn 
            20                  25                  30          


Thr Leu His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asn Asn Ser Arg Arg Pro Ser Gly Val Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Phe Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Leu Tyr Val Phe Gly Thr Gly Pro Arg Ser Pro 
            100                 105                 


<210>  175
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ22 heavy chain CDR1 sequence

<400>  175

Gly Gly Ser Phe Ser Ser Tyr Tyr 
1               5               


<210>  176
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ22 heavy chain CDR2 sequence

<400>  176

Ile Tyr Tyr Thr Gly Ser Thr 
1               5           


<210>  177
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ22 heavy chain CDR3 sequence

<400>  177

Cys Ala Gly Leu Asp Arg Tyr Ala Trp Asn Asp Gly Gly Asp His Trp 
1               5                   10                  15      


<210>  178
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ22 light chain CDR1 sequence

<400>  178

Ser Ser Asn Leu Gly Arg Asn Thr 
1               5               


<210>  179
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ22 light chain CDR2 sequence

<400>  179

Asn Asn Ser 
1           


<210>  180
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ22 light chain CDR3 sequence

<400>  180

Cys Ala Ser Trp Asp Asp Ser Leu Asn Gly Leu Tyr Val Phe 
1               5                   10                  


<210>  181
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ18 heavy chain variable domain nucleotide sequence

<400>  181
caggtgcagt tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatc cactttcatc ggctattata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaactcta atagtggtgg cacaaagttt      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag tacagtctac      240

gcagagctga gcagactgag atctgacgac acggccgtgt attactgtgc gagcaacaaa      300

tggttcagtg gcgatgatgc ttactactcc tacatggacg tctggggcaa agggaccacg      360

gtcatcgtct cctca                                                       375


<210>  182
<211>  297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ18 light chain variable domain nucleotide sequence

<400>  182
tctgtgtcct tgggacagac agtcaggatc acatgccagg gagacatcct cagaagctat       60

tatgcaagtt ggtatcagca gaagccagga caggcccctg tacttgtcct ctatggtaaa      120

aactaccggc cctcagggat cccagaccga ttctctggct ccagctcagg aaacacagct      180

tctttgacca tcactggggc tcaggcggaa gatgaggctg actattactg taactcccga      240

gacaacagtg gtaatcaagt gattttcggc ggagggacca agctgaccgt cctaggt         297


<210>  183
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ18 heavy chain variable domain amino acid sequence

<400>  183

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Thr Phe Ile Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ser Asn Ser Gly Gly Thr Lys Phe Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Ala Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Lys Trp Phe Ser Gly Asp Asp Ala Tyr Tyr Ser Tyr Met 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Ile Val Ser Ser 
        115                 120                 125 


<210>  184
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ18 light chain variable domain amino acid sequence

<400>  184

Ser Val Ser Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ile 
1               5                   10                  15      


Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
            20                  25                  30          


Pro Val Leu Val Leu Tyr Gly Lys Asn Tyr Arg Pro Ser Gly Ile Pro 
        35                  40                  45              


Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile 
    50                  55                  60                  


Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg 
65                  70                  75                  80  


Asp Asn Ser Gly Asn Gln Val Ile Phe Gly Gly Gly Thr Lys Leu Thr 
                85                  90                  95      


Val Leu Gly 
            


<210>  185
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ18 heavy chain CDR1 sequence

<400>  185

Gly Ser Thr Phe Ile Gly Tyr Tyr 
1               5               


<210>  186
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ18 heavy chain CDR2 sequence

<400>  186

Ile Asn Ser Asn Ser Gly Gly Thr 
1               5               


<210>  187
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ18 heavy chain CDR3 sequence

<400>  187

Cys Ala Ser Asn Lys Trp Phe Ser Gly Asp Asp Ala Tyr Tyr Ser Tyr 
1               5                   10                  15      


Met Asp Val Trp 
            20  


<210>  188
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ18 light chain CDR1 sequence

<400>  188

Ile Leu Arg Ser Tyr Tyr 
1               5       


<210>  189
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ18 light chain CDR2 sequence

<400>  189

Gly Lys Asn 
1           


<210>  190
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ18 light chain CDR3 sequence

<400>  190

Cys Asn Ser Arg Asp Asn Ser Gly Asn Gln Val Ile Phe 
1               5                   10              


<210>  191
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ19 heavy chain variable domain nucleotide sequence

<400>  191
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatgatgg gtccttcagt ggttactact ggagctggat ccgccagccc      120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac      180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aaactgagtt ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag gggggtccag      300

cactggggcc agggcaccct ggtcatcgtc tcttca                                336


<210>  192
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ19 light chain variable domain nucleotide sequence

<400>  192
cagtctgtgc tgactcagcc accctcggtg tccaagggct tgagacagac cgccacactc       60

acctgcactg ggaacagcga caatgttgac agccaaggag cagcttggct gcagcagcac      120

cagggccacc ctcccaaact cctatcgtac aggaataaca accggccctc tgggatctca      180

gagagattct ctgcatccag gtcagggaat acagcctccc tgaccattac tggactccag      240

cctgaggacg aggctgacta ttactgctca gcatgggacg gcagcctcag tgcgtgggtg      300

ttcggcgggg ggaccaagct gaccgtccta ggt                                   333


<210>  193
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ19 heavy chain variable domain amino acid sequence

<400>  193

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Asp Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Val Gln His Trp Gly Gln Gly Thr Leu Val Ile Val Ser Ser 
            100                 105                 110         


<210>  194
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ19 light chain variable domain amino acid sequence

<400>  194

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Lys Gly Leu Arg Gln 
1               5                   10                  15      


Thr Ala Thr Leu Thr Cys Thr Gly Asn Ser Asp Asn Val Asp Ser Gln 
            20                  25                  30          


Gly Ala Ala Trp Leu Gln Gln His Gln Gly His Pro Pro Lys Leu Leu 
        35                  40                  45              


Ser Tyr Arg Asn Asn Asn Arg Pro Ser Gly Ile Ser Glu Arg Phe Ser 
    50                  55                  60                  


Ala Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Gly Ser Leu 
                85                  90                  95      


Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  195
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ19 heavy chain CDR1 sequence

<400>  195

Asp Gly Ser Phe Ser Gly Tyr Tyr 
1               5               


<210>  196
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ19 heavy chain CDR2 sequence

<400>  196

Ile Asn His Ser Gly Ser Thr 
1               5           


<210>  197
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ19 heavy chain CDR3 sequence

<400>  197

Cys Ala Arg Gly Val Gln His Trp 
1               5               


<210>  198
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ19 light chain CDR1 sequence

<400>  198

Ser Asp Asn Val Asp Ser Gln Gly 
1               5               


<210>  199
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ19 light chain CDR2 sequence

<400>  199

Arg Asn Asn 
1           


<210>  200
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ19 light chain CDR2 sequence

<400>  200

Cys Ser Ala Trp Asp Gly Ser Leu Ser Ala Trp Val Phe 
1               5                   10              


<210>  201
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ23 heavy chain variable domain nucleotide sequence

<400>  201
gaagtgcagc tggtggagtc cgggggaggc tcagttcagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcaat atctaccgga tgcactgggt ccgccaggct      120

ccagggaagg ggctcgtgtg ggtctcagat atttataatg atggcagtag cacaaactac      180

gcggacagcg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgttt      240

ctgcaaatga acagtctgag agccgaggac acggctgtct actactgtgt cagatctagt      300

ggtgcctttg actactgggg ccagggagcc ctggtcaccg tctcatca                   348


<210>  202
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MZ23 light chain variable domain nucleotide sequence

<400>  202
gaaattgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtatttta aacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct acattgctcg tttactgggc ttctatccgg      180

ggatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcacc      240

atcagcagcc tgcagcctga agatgtggct gtgtattact gtcagcacca ttatagtttt      300

ccgatcacct tcggccaagg gacacgactg gagattaaac ga                         342


<210>  203
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ23 heavy chain variable domain amino acid sequence

<400>  203

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Arg Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Asp Ile Tyr Asn Asp Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Ser Gly Ala Phe Asp Tyr Trp Gly Gln Gly Ala Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  204
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ23 light chain variable domain amino acid sequence

<400>  204

Glu Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Ile Leu Asn Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Thr Leu Leu Val Tyr Trp Ala Ser Ile Arg Gly Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      


His Tyr Ser Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  205
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ23 heavy chain CDR1 sequence

<400>  205

Gly Phe Thr Phe Asn Ile Tyr Arg 
1               5               


<210>  206
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ23 heavy chain CDR2 sequence

<400>  206

Ile Tyr Asn Asp Gly Ser Ser Thr 
1               5               


<210>  207
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ23 heavy chain CDR3 sequence

<400>  207

Cys Val Arg Ser Ser Gly Ala Phe Asp Tyr Trp 
1               5                   10      


<210>  208
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ23 light chain CDR1 sequence

<400>  208

Gln Ser Ile Leu Asn Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  209
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ23 light chain CDR2 sequence

<400>  209

Trp Ala Ser 
1           


<210>  210
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ23 light chain CDR3 sequence

<400>  210

Cys Gln His His Tyr Ser Phe Pro Ile Thr Phe 
1               5                   10      


<210>  211
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ2 heavy chain variable domain nucleotide sequence

<400>  211

Cys Ala Gly Cys Thr Gly Cys Ala Thr Cys Thr Gly Cys Ala Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Gly Gly Gly Cys Cys Cys Ala Gly Gly Ala Cys Thr 
            20                  25                  30          


Gly Gly Thr Gly Ala Ala Gly Cys Cys Thr Thr Cys Gly Gly Ala Gly 
        35                  40                  45              


Ala Cys Cys Cys Thr Gly Thr Cys Cys Cys Thr Cys Ala Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Cys Thr Gly Thr Cys Thr Cys Thr Gly Gly Thr Gly Gly 
65                  70                  75                  80  


Cys Thr Cys Cys Thr Thr Cys Ala Gly Cys Ala Gly Thr Thr Ala Cys 
                85                  90                  95      


Thr Ala Cys Thr Gly Gly Ala Gly Cys Thr Gly Gly Ala Thr Cys Cys 
            100                 105                 110         


Gly Gly Cys Ala Gly Cys Cys Cys Cys Cys Ala Gly Gly Gly Ala Ala 
        115                 120                 125             


Gly Gly Gly Ala Cys Thr Gly Gly Ala Gly Thr Gly Gly Ala Thr Thr 
    130                 135                 140                 


Gly Gly Gly Thr Cys Thr Ala Thr Cys Thr Ala Thr Thr Ala Cys Ala 
145                 150                 155                 160 


Cys Thr Gly Gly Gly Ala Gly Thr Ala Cys Cys Ala Ala Cys Thr Ala 
                165                 170                 175     


Cys Ala Ala Cys Cys Cys Cys Thr Cys Cys Cys Thr Cys Ala Ala Gly 
            180                 185                 190         


Ala Gly Thr Cys Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Ala Thr 
        195                 200                 205             


Cys Ala Gly Thr Thr Gly Ala Cys Gly Cys Gly Thr Cys Cys Ala Ala 
    210                 215                 220                 


Gly Ala Ala Cys Cys Ala Gly Thr Thr Cys Thr Cys Cys Cys Thr Gly 
225                 230                 235                 240 


Ala Gly Gly Cys Thr Gly Ala Ala Cys Thr Cys Thr Gly Thr Gly Ala 
                245                 250                 255     


Cys Cys Gly Cys Cys Gly Cys Ala Gly Ala Cys Ala Cys Gly Gly Cys 
            260                 265                 270         


Cys Ala Thr Ala Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Gly 
        275                 280                 285             


Gly Gly Ala Cys Thr Thr Gly Ala Cys Cys Gly Thr Thr Ala Thr Gly 
    290                 295                 300                 


Cys Cys Thr Gly Gly Ala Ala Cys Gly Ala Cys Gly Gly Ala Gly Gly 
305                 310                 315                 320 


Thr Gly Ala Cys Cys Ala Cys Thr Gly Gly Gly Gly Cys Cys Ala Gly 
                325                 330                 335     


Gly Gly Ala Ala Cys Cys Cys Thr Gly Gly Thr Cys Ala Gly Cys Gly 
            340                 345                 350         


Thr Cys Cys Cys Cys Thr Cys Ala 
        355                 360 


<210>  212
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ2 light chain variable domain nucleotide sequence

<400>  212

Cys Ala Gly Thr Cys Thr Gly Thr Gly Cys Thr Gly Ala Cys Thr Cys 
1               5                   10                  15      


Ala Gly Cys Cys Ala Cys Cys Cys Thr Cys Ala Gly Cys Gly Thr Cys 
            20                  25                  30          


Thr Gly Gly Gly Ala Cys Cys Cys Cys Cys Gly Gly Gly Cys Ala Gly 
        35                  40                  45              


Ala Gly Gly Gly Thr Cys Thr Cys Cys Ala Thr Thr Thr Cys Thr Thr 
    50                  55                  60                  


Gly Thr Thr Cys Thr Gly Gly Ala Ala Gly Cys Ala Gly Cys Thr Cys 
65                  70                  75                  80  


Cys Ala Ala Cys Cys Thr Cys Gly Gly Ala Ala Gly Gly Ala Ala Thr 
                85                  90                  95      


Ala Cys Thr Cys Thr Gly Cys Ala Cys Thr Gly Gly Thr Ala Cys Cys 
            100                 105                 110         


Ala Gly Cys Ala Ala Cys Thr Cys Cys Cys Ala Gly Gly Ala Ala Cys 
        115                 120                 125             


Gly Gly Cys Cys Cys Cys Cys Ala Ala Ala Cys Thr Cys Cys Thr Cys 
    130                 135                 140                 


Ala Thr Cys Thr Ala Thr Ala Ala Thr Ala Ala Thr Ala Gly Thr Cys 
145                 150                 155                 160 


Gly Gly Cys Gly Gly Cys Cys Cys Thr Cys Ala Gly Gly Gly Gly Thr 
                165                 170                 175     


Cys Cys Cys Thr Gly Ala Ala Cys Gly Ala Thr Thr Cys Thr Cys Thr 
            180                 185                 190         


Gly Gly Cys Thr Cys Cys Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala 
        195                 200                 205             


Cys Cys Thr Cys Ala Gly Cys Cys Thr Cys Cys Cys Thr Gly Gly Cys 
    210                 215                 220                 


Cys Ala Thr Cys Ala Gly Thr Gly Gly Gly Cys Thr Cys Cys Ala Gly 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Gly Ala Thr Gly Ala Gly Gly Cys Thr Gly 
                245                 250                 255     


Ala Thr Thr Ala Thr Thr Thr Cys Thr Gly Thr Gly Cys Ala Thr Cys 
            260                 265                 270         


Ala Thr Gly Gly Gly Ala Thr Gly Ala Cys Ala Gly Cys Cys Thr Gly 
        275                 280                 285             


Ala Ala Cys Gly Gly Cys Cys Thr Thr Thr Ala Thr Gly Thr Cys Thr 
    290                 295                 300                 


Thr Cys Gly Gly Ala Ala Cys Thr Gly Gly Gly Ala Cys Cys Ala Ala 
305                 310                 315                 320 


Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Cys Thr Ala Cys Gly Thr 
                325                 330                 335     


<210>  213
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ2 heavy chain variable domain amino acid sequence

<400>  213

Gln Leu His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Ala Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Leu Asp Arg Tyr Ala Trp Asn Asp Gly Gly Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Ser Val Pro Ser 
        115                 120 


<210>  214
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ2 light chain variable domain amino acid sequence

<400>  214

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Ser Cys Ser Gly Ser Ser Ser Asn Leu Gly Arg Asn 
            20                  25                  30          


Thr Leu His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asn Asn Ser Arg Arg Pro Ser Gly Val Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Phe Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Arg 
            100                 105                 110         


<210>  215
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ2 heavy chain CDR1 sequence

<400>  215

Gly Gly Ser Phe Ser Ser Tyr Tyr 
1               5               


<210>  216
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ2 heavy chain CDR2 sequence

<400>  216

Ile Tyr Tyr Thr Gly Ser Thr 
1               5           


<210>  217
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ2 heavy chain CDR3 sequence

<400>  217

Cys Ala Gly Leu Asp Arg Tyr Ala Trp Asn Asp Gly Gly Asp His Trp 
1               5                   10                  15      


<210>  218
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ2 light chain CDR1 sequence

<400>  218

Ser Ser Asn Leu Gly Arg Asn Thr 
1               5               


<210>  219
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ2 light chain CDR2 sequence

<400>  219

Asn Asn Ser 
1           


<210>  220
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MZ2 light chain CDR3 sequence

<400>  220

Cys Ala Ser Trp Asp Asp Ser Leu Asn Gly Leu Tyr Val Phe 
1               5                   10                  


<210>  221
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDE2-A11 heavy chain variable domain amino acid sequence

<400>  221

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Tyr Ser Asn His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Thr Arg Asn Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Thr Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Gly Val Arg Phe Tyr Tyr Asp Ser Thr Gly Tyr Tyr Pro 
            100                 105                 110         


Asp Ser Phe Phe Lys Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  222
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDE2-A11 light chain variable domain amino acid sequence

<400>  222

Gln Ser Val Leu Thr Gln Pro Val Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Ala Asp Thr Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Gly Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Ala Thr Ala Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Thr Ser 
                85                  90                  95      


Arg Thr Leu Val Phe Gly Gly Gly Thr 
            100                 105 


<210>  223
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDE2-A11 heavy chain CDR1 sequence

<400>  223

Asn His Trp Met His 
1               5   


<210>  224
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDE2-A11 heavy chain CDR2 sequence

<400>  224

Arg Ile Asn Ser Asp Gly Ser Thr Arg Asn Tyr Ala Asp Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210>  225
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDE2-A11 heavy chain CDR3 sequence

<400>  225

Asp Gly Val Arg Phe Tyr Tyr Asp Ser Thr Gly Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Phe Phe Lys Tyr Gly Met Asp Val 
            20                  


<210>  226
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDE2-A11 light chain CDR1 sequence

<400>  226

Thr Gly Thr Ser Ser Asn Ala Asp Thr Tyr Asn Leu Val Ser 
1               5                   10                  


<210>  227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDE2-A11 light chain CDR2 sequence

<400>  227

Glu Gly Thr Lys Arg Pro Ser 
1               5           


<210>  228
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDE2-A11 light chain CDR3 sequence

<400>  228

Cys Ser Tyr Ala Thr Ser Arg Thr Leu Val 
1               5                   10  


<210>  229
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab513 heavy chain amino acid sequence

<400>  229

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Gly Phe Asn Ile Lys Asp Val Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Glu Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Arg Ile Asp Pro Glu Asn Gly Asp Thr Lys Tyr Asp Pro Lys Leu Gln 
    50                  55                  60                  


Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Trp Glu Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  230
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab513 light chain amino acid sequence

<400>  230

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Asn Val Asp Lys Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Glu Leu Gln Trp Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Arg Ser Asn 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  231
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab513 heavy chain CDR1 sequence

<400>  231

Val Tyr Met Ser 
1               


<210>  232
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab513 heavy chain CDR2 sequence

<400>  232

Arg Ile Asp Pro Glu Asn Gly Asp Thr Lys Tyr Asp Pro Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  233
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab513 heavy chain CDR3 sequence

<400>  233

Gly Trp Glu Gly Phe Ala Tyr 
1               5           


<210>  234
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab513 light chain CDR1 sequence

<400>  234

Arg Ala Ser Glu Asn Val Asp Lys Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  235
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab513 light chain CDR2 sequence

<400>  235

Arg Ala Ser Glu Leu Gln Trp 
1               5           


<210>  236
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab513 light chain CDR3 sequence

<400>  236

Gln Arg Ser Asn Glu Val Pro Trp Thr 
1               5                   


