                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120>  METHODS AND COMPOSITIONS FOR SKELETAL AND NEUROLOGICAL DISORDERS

<130>  74578-2140

<140>  PCT/US2019/029161
<141>  2019-04-25

<150>  62/662,435
<151>  2018-04-25

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: Mouse Alp primer

<400>  1
actgatgtgg aatacgaact ggatgagaag g                                      31


<210>  2
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence:  Art-Mouse Alp primer

<400>  2
cagtcaggtt gttccgattc aattcatact gc                                     32


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: Mouse Collagen I Alpha 1 primer

<400>  3
ctggcggttc aggtccaat                                                    19


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: Mouse Collagen I Alpha 1 primer


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, or t

<400>  4
ttccaggcaa tccacgagcs dn                                                22


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: Mouse Collagen I Alpha 2 primer

<400>  5
aagggtgcta ctggactccc                                                   20


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: Mouse Collagen I Alpha 2 primer

<400>  6
ttgttaccgg attctccttt gg                                                22


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: mouse Ocn

<400>  7
ctgccctaaa gcccaaactc t                                                 21


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: mouse Ocn

<400>  8
gagaggacag ggaggatcaa                                                   20


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: mouse  Opn

<400>  9
agcaagaaac tcttccaagc aa                                                22


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: mouse  Opn

<400>  10
gtgagattcg tcagattcat ccg                                               23


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: mouse Bsp

<400>  11
atggagacgg cgatagttcc                                                   20


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: mouse Bsp

<400>  12
ctagctgtta cacccgagag t                                                 21


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: NFact2 primer forward primer

<400>  13
ctttcagatg ggaataaacg tc                                                22


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: NFact2 primer reverse primer

<400>  14
tcctactcac atagcaacag aa                                                22


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: Gapdh primer,  forward primer

<400>  15
attcaacggc acatgcaagg                                                   20


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: Gapdh primer, reverse primer


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is a, c, g, or t

<400>  16
gatgttagtg gggtctcgct csdn                                              24


<210>  17
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: Phage Display Protein

<400>  17

Ala Arg Gly Ser Glu Phe Asn Leu Met Asn Leu Asp Tyr Glu Ile Ser 
1               5                   10                  15      


Phe Gly Gly Ile Pro Ala Pro Gly Lys Ser Val Ser Phe Pro His Arg 
            20                  25                  30          


Asn Phe His Gly Cys Leu Glu Asn Leu Tyr Tyr Asn Gly Val Asp Ile 
        35                  40                  45              


Ile Asp Leu Ala Lys Gln Gln Lys Pro Gln Ile Ile Ala Met Gly Asn 
    50                  55                  60                  


Val Ser Phe Ser Cys Ser Gln Pro Gln Ser Met Pro Val Thr Phe Leu 
65                  70                  75                  80  


Ser Ser Arg Ser Tyr Leu Ala Leu Pro Asp Phe Ser Gly Glu Glu Glu 
                85                  90                  95      


Val Ser Ala Thr Phe Gln Phe Arg Thr Trp Asn Lys Ala Gly Leu Leu 
            100                 105                 110         


Leu Phe Ser Glu Leu Gln Leu Ile Ser Gly Gly Ile Leu Leu Phe Leu 
        115                 120                 125             


Ser Asp Gly Lys Leu Lys Ser Asn Leu Tyr Gln Pro Gly Lys Leu Pro 
    130                 135                 140                 


Ser Asp Ile Thr Ala Gly Val Glu Leu Asn Asp Gly Gln Trp His Ser 
145                 150                 155                 160 


Val Ser Leu Ser Ala Lys Lys Asn His Leu Ser Val Ala Val Asp Gly 
                165                 170                 175     


Gln Met Ala Ser Ala Ala Pro Leu Leu Gly Pro Glu Gln Ile Tyr Ser 
            180                 185                 190         


Gly Gly Thr Tyr Tyr Phe Gly Gly Cys Pro Asp Lys Ser Leu 
        195                 200                 205     


<210>  18
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: BLAST search consensus sequence

<400>  18

Ala Arg Gly Glu Phe Asn Leu Met Asn Leu Asp Tyr Glu Ile Ser Phe 
1               5                   10                  15      


Gly Gly Ile Pro Ala Pro Gly Lys Ser Val Ser Phe Pro His Arg Asn 
            20                  25                  30          


Phe His Gly Cys Leu Glu Asn Leu Tyr Tyr Asn Gly Val Asp Ile Ile 
        35                  40                  45              


Asp Leu Ala Lys Gln Gln Lys Pro Gln Ile Ile Ala Met Gly Asn Val 
    50                  55                  60                  


Ser Phe Ser Cys Ser Gln Pro Gln Ser Met Pro Val Thr Phe Leu Ser 
65                  70                  75                  80  


Ser Arg Ser Tyr Leu Ala Leu Pro Asp Phe Ser Gly Glu Glu Glu Val 
                85                  90                  95      


Ser Ala Thr Phe Gln Phe Arg Thr Trp Asn Lys Ala Gly Leu Leu Leu 
            100                 105                 110         


Phe Ser Glu Leu Gln Leu Ile Ser Gly Gly Ile Leu Leu Phe Leu Ser 
        115                 120                 125             


Asp Gly Lys Leu Lys Ser Asn Leu Tyr Gln Pro Gly Lys Leu Pro Ser 
    130                 135                 140                 


Asp Ile Thr Ala Gly Val Glu Leu Asn Asp Gly Gln Trp His Ser Val 
145                 150                 155                 160 


Ser Leu Ser Ala Lys Lys Asn His Leu Ser Val Ala Val Asp Gly Gln 
                165                 170                 175     


Met Ala Ser Ala Ala Pro Leu Leu Gly Pro Glu Gln Ile Tyr Ser Gly 
            180                 185                 190         


Gly Thr Tyr Tyr Phe Gly Gly Cys Pro Asp Lys Ser 
        195                 200                 


<210>  19
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  19

Ala Arg Gly Glu Phe Asn Leu Met Asn Leu Asp Tyr Glu Ile Ser Phe 
1               5                   10                  15      


Gly Gly Ile Pro Ala Pro Gly Lys Ser Val Ser Phe Pro His Arg Asn 
            20                  25                  30          


Phe His Gly Cys Leu Glu Asn Leu Tyr Tyr Asn Gly Val Asp Ile Ile 
        35                  40                  45              


Asp Leu Ala Lys Gln Gln Lys Pro Gln Ile Ile Ala Met Gly Asn Val 
    50                  55                  60                  


Ser Phe Ser Cys Ser Gln Pro Gln Ser Met Pro Val Thr Phe Leu Ser 
65                  70                  75                  80  


Ser Arg Ser Tyr Leu Ala Leu Pro Asp Phe Ser Gly Glu Glu Glu Val 
                85                  90                  95      


Ser Ala Thr Phe Gln Phe Arg Thr Trp Asn Lys Ala Gly Leu Leu Leu 
            100                 105                 110         


Phe Ser Glu Leu Gln Leu Ile Ser Gly Gly Ile Leu Leu Phe Leu Ser 
        115                 120                 125             


Asp Gly Lys Leu Lys Ser Asn Leu Tyr Gln Pro Gly Lys Leu Pro Ser 
    130                 135                 140                 


Asp Ile Thr Ala Gly Val Glu Leu Asn Asp Gly Gln Trp His Ser Val 
145                 150                 155                 160 


Ser Leu Ser Ala Lys Lys Asn His Leu Ser Val Ala Val Asp Gly Gln 
                165                 170                 175     


Met Ala Ser Ala Ala Pro Leu Leu Gly Pro Glu Gln Ile Tyr Ser Gly 
            180                 185                 190         


Gly Thr Tyr Tyr Phe Gly Gly Cys Pro Asp Lys Ser 
        195                 200                 


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: Primer

<400>  20
cacggtacct gggaattcct at                                                22


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: Primer

<400>  21
ttactcgagc tgcagagtca ctt                                               23


