               SEQUENCE LISTING

<110> Qiagen Beverly, LLC

<120> Thermostable viral reverse transcriptase

<130> QIA19027PCT

<160> 88

<170> BiSSAP 1.3.6

<210> 1
<211> 1734
<212> DNA
<213> Artificial Sequence


<220> 
<223> M66 DNA

<400> 1
atgaataccc cgaaaccgat tctgaaaccg cagagcaaag cactggttga accggtgctg      60

tgtaatagca ttgatgaaat tccggcaaaa tacaacgagc cgatctattt tgatctggca     120

accgatgaag atcgtccggt tctggcaagc atttatcagc cgcattttga acgtaaagtg     180

tattgtctga atctgctgaa agaaaacccg gaacgtttta aagaatggct gctgaaattt     240

agcgaaattc gtggttgggg cttagatttc gatctgcgtg ttctgggtta tacctatgaa     300

cagctgcgta acaaaaaaat cattgatgtt cagctggccc tgaaagtgca gcattatgaa     360

cgctttaaac agaatggtgc caaaggtgaa ggttttcgtc tggatgatgt tgcacgtgat     420

ctgctgggta ttgaatatcc gatgaacaaa acgaaaatcc gcaccacctt caagtataac     480

atgtatagca gcttttcgta cgagcaactg ctgtatgcaa gcctggatgc atatattccg     540

catctgctgt acgaacgtct gagcagcgat accctgaata gcctggttta tcagattgat     600

caagaggttc agaaagtggt gattgaaacc agccagcatg gtatgccggt taaactgaaa     660

gcactggaag aagaaattca tcgtctgacc cagctgcgta gcgaaatgca gaaacaaatt     720

ccgtttaact ataatagccc gaaacagacc gccaaattct ttggtgttaa tagcagcagc     780

aaagatgttc tgatggatct ggcactgcgt ggtaatgaag ttgccaaaaa agttctggaa     840

gcacgccaga ttgaaaaaag tctggcattc gccaaagatc tgtatgatat cgccaaaaaa     900

aacggtggtc gcatctatgg taactttttt accaccaccg caccgagcgg tcgtatgagc     960

tgtagcgata ttaacctgca gcaaattccg cgtcgtctgc gtccgtttat tggttttgaa    1020

accgaagata aaaagctgat caccgcagat tttccgcaga ttgaactgcg tctggcaggc    1080

gttatttggg atgaaccgaa atttatcgaa gcatttcgtc agggtatcga tctgcataaa    1140

ctgaccgcaa gcattctgtt cgataaaaac attgaagagg tgagcaaaga agaacgccag    1200

attggtaaaa gcgcaaattt tggtctgatt tatggtatca gcccgaaagg ttttgccgaa    1260

tattgtatta gcaacggcat taacatcacc gaagaaatgg caatcgagat cgtgaaaaaa    1320

tggaagaagt tctatcgcaa aatcgccgaa cagcatcagc tggcatatga acgtttcaaa    1380

tatgccgaat tcgtggataa tgaaacctgg ctgaatcgta cctatcgtgc atggaaaccg    1440

caagatctgc tgaattatca gattcaaggt agcggtgcag aactgttcaa aaaagcaatt    1500

atcctgctta aagaagccaa accggatctg aaaattgtga atctggtgca tgatgaaatt    1560

gtggttgaag ccgatagcaa agaagcacag gatctggcaa aactgattaa agaaaaaatg    1620

gaagaagcct gggattggtg tctggaaaaa gccgaagaat ttggtaatcg tgtggccaaa    1680

atcaaactgg aagttgagga gccgcatgtt ggtaatacct gggaaaaacc gtaa          1734


<210> 2
<211> 577
<212> PRT
<213> Artificial Sequence


<220> 
<223> M66 PRT

<400> 2
Met Asn Thr Pro Lys Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val 
1               5                   10                  15      
Glu Pro Val Leu Cys Asn Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn 
            20                  25                  30          
Glu Pro Ile Tyr Phe Asp Leu Ala Thr Asp Glu Asp Arg Pro Val Leu 
        35                  40                  45              
Ala Ser Ile Tyr Gln Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn 
    50                  55                  60                  
Leu Leu Lys Glu Asn Pro Glu Arg Phe Lys Glu Trp Leu Leu Lys Phe 
65                  70                  75                  80  
Ser Glu Ile Arg Gly Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly 
                85                  90                  95      
Tyr Thr Tyr Glu Gln Leu Arg Asn Lys Lys Ile Ile Asp Val Gln Leu 
            100                 105                 110         
Ala Leu Lys Val Gln His Tyr Glu Arg Phe Lys Gln Asn Gly Ala Lys 
        115                 120                 125             
Gly Glu Gly Phe Arg Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile 
    130                 135                 140                 
Glu Tyr Pro Met Asn Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn 
145                 150                 155                 160 
Met Tyr Ser Ser Phe Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp 
                165                 170                 175     
Ala Tyr Ile Pro His Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu 
            180                 185                 190         
Asn Ser Leu Val Tyr Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile 
        195                 200                 205             
Glu Thr Ser Gln His Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu 
    210                 215                 220                 
Glu Ile His Arg Leu Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile 
225                 230                 235                 240 
Pro Phe Asn Tyr Asn Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val 
                245                 250                 255     
Asn Ser Ser Ser Lys Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn 
            260                 265                 270         
Glu Val Ala Lys Lys Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu 
        275                 280                 285             
Ala Phe Ala Lys Asp Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg 
    290                 295                 300                 
Ile Tyr Gly Asn Phe Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser 
305                 310                 315                 320 
Cys Ser Asp Ile Asn Leu Gln Gln Ile Pro Arg Arg Leu Arg Pro Phe 
                325                 330                 335     
Ile Gly Phe Glu Thr Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro 
            340                 345                 350         
Gln Ile Glu Leu Arg Leu Ala Gly Val Ile Trp Asp Glu Pro Lys Phe 
        355                 360                 365             
Ile Glu Ala Phe Arg Gln Gly Ile Asp Leu His Lys Leu Thr Ala Ser 
    370                 375                 380                 
Ile Leu Phe Asp Lys Asn Ile Glu Glu Val Ser Lys Glu Glu Arg Gln 
385                 390                 395                 400 
Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys 
                405                 410                 415     
Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu 
            420                 425                 430         
Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile 
        435                 440                 445             
Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe 
    450                 455                 460                 
Val Asp Asn Glu Thr Trp Leu Asn Arg Thr Tyr Arg Ala Trp Lys Pro 
465                 470                 475                 480 
Gln Asp Leu Leu Asn Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe 
                485                 490                 495     
Lys Lys Ala Ile Ile Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile 
            500                 505                 510         
Val Asn Leu Val His Asp Glu Ile Val Val Glu Ala Asp Ser Lys Glu 
        515                 520                 525             
Ala Gln Asp Leu Ala Lys Leu Ile Lys Glu Lys Met Glu Glu Ala Trp 
    530                 535                 540                 
Asp Trp Cys Leu Glu Lys Ala Glu Glu Phe Gly Asn Arg Val Ala Lys 
545                 550                 555                 560 
Ile Lys Leu Glu Val Glu Glu Pro His Val Gly Asn Thr Trp Glu Lys 
                565                 570                 575     
Pro 
    

<210> 3
<211> 1734
<212> DNA
<213> Artificial Sequence


<220> 
<223> M160 DNA

<400> 3
atgaataccc cgaaaccgat tctgaaaccg cagagcaaag cactggttga acctgttctg      60

tgtgatagca ttgatgaaat tccggcaaaa tacaatgaac ctgtgtattt tgatctggca     120

accgatgaag atcgtccggt tctggcaagc atttatcagc cgcattttga acgtaaagtg     180

tattgtctga atctgctgcg tgaaaaactg gcacgtttta aagaatggct gctgaaattt     240

agcgaaattc gtggttgggg cttagatttc gatctgcgtg ttctgggtta tacctatgaa     300

cagctgcgca acaaaaaaat cgttgacgtc cagctggcca ttaaagtgca gcattatgaa     360

cgctttaaac aaggtggcac caaaggtgaa ggttttcgtc tggatgatgt tgcacgtgat     420

ctgctgggta ttgaatatcc gatgaacaaa acgaaaatcc gcaccacctt caagtataac     480

atgtatagca gcttttcgta cgagcaactg ctgtatgcaa gcctggatgc atatattccg     540

catctgctgt acgaacgtct gagcagcgat accctgaata gcctggttta tcagattgat     600

caagaggttc agaaagtggt gattgaaacc agccagcatg gtatgccggt taaactgaaa     660

gcactggaag aagaaattca tcgtctgacc cagctgcgta gcgaaatgca gaaacaaatt     720

ccgtttaact ataatagccc gaaacagacc gccaaattct ttggtgttaa tagcagcagc     780

aaagatgttc tgatggatct ggcactgcgt ggtaatgaag ttgccaaaaa agttctggaa     840

gcacgccaga ttgaaaaaag tctggcattc gccaaagatc tgtatgatat cgccaaaaaa     900

aacggtggtc gcatctatgg taactttttt accaccaccg caccgagcgg tcgtatgagc     960

tgtagcgata ttaacctgca gcaaattccg cgtcgtctgc gtccgtttat tggttttgaa    1020

accgaggaca aaaaactgat caccgcagat tttccgcaga ttgaactgcg tctggcaggc    1080

gttatgtgga atgaacctga atttctgaaa gcctttcgtg atggcattga tctgcacaaa    1140

ctgaccgcaa gtattctgtt cgataaaaag attaacgaag tgagcaaaga ggaacgccag    1200

atcggtaaaa gcgcaaattt tggtctgatt tatggtatca gcccgaaagg ttttgccgaa    1260

tattgtatta gcaacggcat taacatcacc gaagaaatgg caatcgagat cgtgaaaaaa    1320

tggaagaagt tctatcgcaa aatcgccgaa cagcatcagc tggcatatga acgtttcaaa    1380

tatgccgaat tcgtggataa tgaaacctgg ctgaatcgtc cgtatcgtgc atggaaaccg    1440

caagatctgc tgaactatca gattcaaggt agcggtgcag aactgttcaa aaaagcaatt    1500

gttctgctga aagaagccaa accggatctg aaaattgtga atctggttca cgatgaaatt    1560

gtggtggaaa ccagtaccga agaagcagaa gatattgcac tgctggtgaa acaaaagatg    1620

gaagaggcat gggattattg cctggaaaaa gcaaaagaat ttggcaataa cgtggccgac    1680

attaaactgg aagttgaaaa accgaatatt agcagcgtgt gggaaaaaga ataa          1734


<210> 4
<211> 577
<212> PRT
<213> Artificial Sequence


<220> 
<223> M160 PRT

<400> 4
Met Asn Thr Pro Lys Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val 
1               5                   10                  15      
Glu Pro Val Leu Cys Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn 
            20                  25                  30          
Glu Pro Val Tyr Phe Asp Leu Ala Thr Asp Glu Asp Arg Pro Val Leu 
        35                  40                  45              
Ala Ser Ile Tyr Gln Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn 
    50                  55                  60                  
Leu Leu Arg Glu Lys Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe 
65                  70                  75                  80  
Ser Glu Ile Arg Gly Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly 
                85                  90                  95      
Tyr Thr Tyr Glu Gln Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu 
            100                 105                 110         
Ala Ile Lys Val Gln His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys 
        115                 120                 125             
Gly Glu Gly Phe Arg Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile 
    130                 135                 140                 
Glu Tyr Pro Met Asn Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn 
145                 150                 155                 160 
Met Tyr Ser Ser Phe Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp 
                165                 170                 175     
Ala Tyr Ile Pro His Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu 
            180                 185                 190         
Asn Ser Leu Val Tyr Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile 
        195                 200                 205             
Glu Thr Ser Gln His Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu 
    210                 215                 220                 
Glu Ile His Arg Leu Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile 
225                 230                 235                 240 
Pro Phe Asn Tyr Asn Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val 
                245                 250                 255     
Asn Ser Ser Ser Lys Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn 
            260                 265                 270         
Glu Val Ala Lys Lys Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu 
        275                 280                 285             
Ala Phe Ala Lys Asp Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg 
    290                 295                 300                 
Ile Tyr Gly Asn Phe Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser 
305                 310                 315                 320 
Cys Ser Asp Ile Asn Leu Gln Gln Ile Pro Arg Arg Leu Arg Pro Phe 
                325                 330                 335     
Ile Gly Phe Glu Thr Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro 
            340                 345                 350         
Gln Ile Glu Leu Arg Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe 
        355                 360                 365             
Leu Lys Ala Phe Arg Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser 
    370                 375                 380                 
Ile Leu Phe Asp Lys Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln 
385                 390                 395                 400 
Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys 
                405                 410                 415     
Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu 
            420                 425                 430         
Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile 
        435                 440                 445             
Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe 
    450                 455                 460                 
Val Asp Asn Glu Thr Trp Leu Asn Arg Pro Tyr Arg Ala Trp Lys Pro 
465                 470                 475                 480 
Gln Asp Leu Leu Asn Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe 
                485                 490                 495     
Lys Lys Ala Ile Val Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile 
            500                 505                 510         
Val Asn Leu Val His Asp Glu Ile Val Val Glu Thr Ser Thr Glu Glu 
        515                 520                 525             
Ala Glu Asp Ile Ala Leu Leu Val Lys Gln Lys Met Glu Glu Ala Trp 
    530                 535                 540                 
Asp Tyr Cys Leu Glu Lys Ala Lys Glu Phe Gly Asn Asn Val Ala Asp 
545                 550                 555                 560 
Ile Lys Leu Glu Val Glu Lys Pro Asn Ile Ser Ser Val Trp Glu Lys 
                565                 570                 575     
Glu 
    

<210> 5
<211> 1734
<212> DNA
<213> Artificial Sequence


<220> 
<223> M180 DNA

<400> 5
atgaataccc cgaaaccgat tctgaaaccg cagccgaagg ccttggttga acctgttctg      60

tgtgatagca ttgatgaaat tccggcacgc tttgatgagg tgatctattt tgatctggca     120

accgatgaag atcgtccggt tctggcaagc atttatcagc cgcattttga acgtaaagtg     180

tattgtctga atctgctgcg tgaaaaactg gcacgtttta aagaatggct gctgaaattt     240

agcgaaattc gtggttgggg cttagatttc gatctgcgtg ttctgggttt tacctatgaa     300

cagctgaaga acaaaaaaat cattgatgtt cagctggccc tgaaagtgca gcattatgaa     360

cgctttaaac aaggtggcac caaaggtgaa ggttttcgtc tggatgatgt tgcacgtgat     420

ctgctgggta ttgaatatcc gatgaacaaa accaaaatcc gcgaaacctt caaaaacaac     480

atgtttcaca gctttagcaa cgagcaactg ctgtatgcaa gctttgatgc atatattccg     540

catctgctgt acgaacagct gaccagcagc accctgaata gcctggttta tcagctggat     600

cagcaggcac agaaaattgt tattgaaacc agccagcatg gtatgccggt taaactgaaa     660

gccctggaag aagaaattca tcgtctgacc cagctgcgtt cagaaatgca gcgtcagatt     720

ccgtttaact ataatagccc gaaacagacc gcaaaattct ttggtgttga tagcagcagc     780

aaagatgttc tgatggatct ggcactgcag ggtaatgaaa tggcaaaaaa agtactggaa     840

gcccgtcaga ttgaaaaaag cctggcattt gcaaaagacc tgtatgatat tgcaaaacgt     900

agcggtggtc gcatttatgg caactttttc accaccaccg caccgagcgg tcgtatgagc     960

tgtagcgata ttaatctgca gcaaattccg cgtcgtctgc gtagctttat tggttttgat    1020

accgaagata aaaaactgat taccgcagat tttccgcaga ttgaactgcg tctggcaggc    1080

gttatgtgga atgaacctga atttctgaaa gcctttcgtg atggcattga tctgcacaaa    1140

ctgaccgcaa gcattctgtt cgataaaaag attaacgaag tgagcaaaga ggaacgccag    1200

atcggtaaaa gcgcaaattt tggtctgatt tatggtatca gcccgaaagg ttttgccgaa    1260

tattgtatta gcaacggcat taacatcacc gaagaaatgg caatcgagat cgtgaaaaaa    1320

tggaagaagt tctatcgcaa aatcgccgaa cagcatcagc tggcatatga acgtttcaaa    1380

tatgccgaat tcgtggataa tgaaacctgg ctgaatcgtc cgtatcgtgc atataaaccg    1440

caggacctgc tgaactatca gattcaaggt agcggtgcag aactgttcaa aaaagcaatt    1500

gtgctgctga aagaaaccaa accggatctg aaaattgtga atctggtgca tgatgaaatt    1560

gtggttgaag ccgatagcaa agaagcacag gatctggcaa aactgattaa agaaaaaatg    1620

gaagaagcct gggattggtg tctggaaaaa gccgaagaat ttggtaatcg tgtggccaaa    1680

atcaaactgg aagttgagga gccgcatgtt ggtaatacct gggaaaaacc gtaa          1734


<210> 6
<211> 577
<212> PRT
<213> Artificial Sequence


<220> 
<223> M180 PRT

<400> 6
Met Asn Thr Pro Lys Pro Ile Leu Lys Pro Gln Pro Lys Ala Leu Val 
1               5                   10                  15      
Glu Pro Val Leu Cys Asp Ser Ile Asp Glu Ile Pro Ala Arg Phe Asp 
            20                  25                  30          
Glu Val Ile Tyr Phe Asp Leu Ala Thr Asp Glu Asp Arg Pro Val Leu 
        35                  40                  45              
Ala Ser Ile Tyr Gln Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn 
    50                  55                  60                  
Leu Leu Arg Glu Lys Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe 
65                  70                  75                  80  
Ser Glu Ile Arg Gly Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly 
                85                  90                  95      
Phe Thr Tyr Glu Gln Leu Lys Asn Lys Lys Ile Ile Asp Val Gln Leu 
            100                 105                 110         
Ala Leu Lys Val Gln His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys 
        115                 120                 125             
Gly Glu Gly Phe Arg Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile 
    130                 135                 140                 
Glu Tyr Pro Met Asn Lys Thr Lys Ile Arg Glu Thr Phe Lys Asn Asn 
145                 150                 155                 160 
Met Phe His Ser Phe Ser Asn Glu Gln Leu Leu Tyr Ala Ser Phe Asp 
                165                 170                 175     
Ala Tyr Ile Pro His Leu Leu Tyr Glu Gln Leu Thr Ser Ser Thr Leu 
            180                 185                 190         
Asn Ser Leu Val Tyr Gln Leu Asp Gln Gln Ala Gln Lys Ile Val Ile 
        195                 200                 205             
Glu Thr Ser Gln His Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu 
    210                 215                 220                 
Glu Ile His Arg Leu Thr Gln Leu Arg Ser Glu Met Gln Arg Gln Ile 
225                 230                 235                 240 
Pro Phe Asn Tyr Asn Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val 
                245                 250                 255     
Asp Ser Ser Ser Lys Asp Val Leu Met Asp Leu Ala Leu Gln Gly Asn 
            260                 265                 270         
Glu Met Ala Lys Lys Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu 
        275                 280                 285             
Ala Phe Ala Lys Asp Leu Tyr Asp Ile Ala Lys Arg Ser Gly Gly Arg 
    290                 295                 300                 
Ile Tyr Gly Asn Phe Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser 
305                 310                 315                 320 
Cys Ser Asp Ile Asn Leu Gln Gln Ile Pro Arg Arg Leu Arg Ser Phe 
                325                 330                 335     
Ile Gly Phe Asp Thr Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro 
            340                 345                 350         
Gln Ile Glu Leu Arg Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe 
        355                 360                 365             
Leu Lys Ala Phe Arg Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser 
    370                 375                 380                 
Ile Leu Phe Asp Lys Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln 
385                 390                 395                 400 
Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys 
                405                 410                 415     
Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu 
            420                 425                 430         
Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile 
        435                 440                 445             
Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe 
    450                 455                 460                 
Val Asp Asn Glu Thr Trp Leu Asn Arg Pro Tyr Arg Ala Tyr Lys Pro 
465                 470                 475                 480 
Gln Asp Leu Leu Asn Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe 
                485                 490                 495     
Lys Lys Ala Ile Val Leu Leu Lys Glu Thr Lys Pro Asp Leu Lys Ile 
            500                 505                 510         
Val Asn Leu Val His Asp Glu Ile Val Val Glu Ala Asp Ser Lys Glu 
        515                 520                 525             
Ala Gln Asp Leu Ala Lys Leu Ile Lys Glu Lys Met Glu Glu Ala Trp 
    530                 535                 540                 
Asp Trp Cys Leu Glu Lys Ala Glu Glu Phe Gly Asn Arg Val Ala Lys 
545                 550                 555                 560 
Ile Lys Leu Glu Val Glu Glu Pro His Val Gly Asn Thr Trp Glu Lys 
                565                 570                 575     
Pro 
    

<210> 7
<211> 1734
<212> DNA
<213> Artificial Sequence


<220> 
<223> M295 DNA

<400> 7
atgaataccc cgaaaccgat tctgaaaccg cagccgaagg ccttggttga acctgttctg      60

tgtgatagca ttgatgaaat tccggcaaaa tacaatgaac ctgtgtattt tgatctggca     120

accgatgaag atagaccggt tctggcaagc atttatcagc cgcattttga acgtaaagtg     180

tattgtctga atctgctgaa agaaaaagtg gcacgcttta aagattggct gctgaaattt     240

agcgaaattc gtggttgggg cttagatttc gatctgcgtg ttctgggtta tacctatgaa     300

cagctgcgca acaaaaaaat cgttgacgtc cagctggcca ttaaagtgca gcattatgaa     360

cgttttaaac agggtggcac caaaggtgaa ggttttcgtc tggatgatgt tgcacgtgat     420

ctgctgggta ttgaatatcc gatgaacaaa acgaaaatcc gcaccacctt caagtataac     480

atgtatagca gcttttcgta cgagcaactg ctgtatgcaa gcctggatgc atatattccg     540

catctgctgt acgaacgtct gagcagcgat accctgaata gcctggttta tcagattgat     600

caagaggttc agaaagtggt gattgaaacc agccagcatg gtatgccggt taaactgcag     660

gcactggaag aagaaattca tcgtctgatt cagctgcgtt cagaaatgca gcgtcagatt     720

ccgtttaact ataatagccc gaaacagacc gcaaaattct ttggtgttga tagcagcagc     780

aaagatgttc tgatggatct ggcactgcgt ggtaatgaag ttgccaaaaa agttctggaa     840

gcacgccaga ttgaaaaaag tctggcattc gccaaagatc tgtatgatat cgccaaaaaa     900

aacggtggtc gcatctatgg taactttttt accaccaccg caccgagcgg tcgtatgagc     960

tgtagcgata ttaacctgca gcaaattccg cgtcgtctgc gtagctttat tggttttgat    1020

accgaagata aaaaactgat taccgcagat tttccgcaga ttgaactgcg tctggcaggc    1080

gttatttgga atgaaccgaa attcattgaa gcctttcgcc agggtattga tctgcataaa    1140

ctgaccgcta gcattctgtt tgataaaaac attgaagaag tgagcaaaga agaacgccag    1200

attggtaaaa gcgcaaattt tggtctgatt tatggtatca gcccgaaagg ttttgccgaa    1260

tattgtatta gcaacggcat taacatcacc gaagaaatgg caatcgagat cgtgaaaaaa    1320

tggaagaagt tctatcgcaa aatcgccgaa cagcatcagc tggcatatga acgtttcaaa    1380

tatgccgaat tcgtggataa tgaaacctgg ctgaatcgtc cgtatcgtgc atataaaccg    1440

caggacctgc tgaactatca gattcagggt agcggtgcag aactgttcaa aaaagcaatt    1500

gttctgctga aagaagccaa accggatctg aaaattgtga atctggttca cgatgaaatt    1560

gtggtggaag cagatagtaa agaagcacag gatctggcca aactgatcaa agaaaagatg    1620

gaagaggcat gggattggtg tctggaaaaa gccgaagaat ttggtaatcg tgtggccaaa    1680

atcaaactgg aagttgaaga accgaatgtg ggtaatacct gggaaaaacc gtaa          1734


<210> 8
<211> 577
<212> PRT
<213> Artificial Sequence


<220> 
<223> M295 PRT

<400> 8
Met Asn Thr Pro Lys Pro Ile Leu Lys Pro Gln Pro Lys Ala Leu Val 
1               5                   10                  15      
Glu Pro Val Leu Cys Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn 
            20                  25                  30          
Glu Pro Val Tyr Phe Asp Leu Ala Thr Asp Glu Asp Arg Pro Val Leu 
        35                  40                  45              
Ala Ser Ile Tyr Gln Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn 
    50                  55                  60                  
Leu Leu Lys Glu Lys Val Ala Arg Phe Lys Asp Trp Leu Leu Lys Phe 
65                  70                  75                  80  
Ser Glu Ile Arg Gly Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly 
                85                  90                  95      
Tyr Thr Tyr Glu Gln Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu 
            100                 105                 110         
Ala Ile Lys Val Gln His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys 
        115                 120                 125             
Gly Glu Gly Phe Arg Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile 
    130                 135                 140                 
Glu Tyr Pro Met Asn Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn 
145                 150                 155                 160 
Met Tyr Ser Ser Phe Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp 
                165                 170                 175     
Ala Tyr Ile Pro His Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu 
            180                 185                 190         
Asn Ser Leu Val Tyr Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile 
        195                 200                 205             
Glu Thr Ser Gln His Gly Met Pro Val Lys Leu Gln Ala Leu Glu Glu 
    210                 215                 220                 
Glu Ile His Arg Leu Ile Gln Leu Arg Ser Glu Met Gln Arg Gln Ile 
225                 230                 235                 240 
Pro Phe Asn Tyr Asn Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val 
                245                 250                 255     
Asp Ser Ser Ser Lys Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn 
            260                 265                 270         
Glu Val Ala Lys Lys Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu 
        275                 280                 285             
Ala Phe Ala Lys Asp Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg 
    290                 295                 300                 
Ile Tyr Gly Asn Phe Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser 
305                 310                 315                 320 
Cys Ser Asp Ile Asn Leu Gln Gln Ile Pro Arg Arg Leu Arg Ser Phe 
                325                 330                 335     
Ile Gly Phe Asp Thr Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro 
            340                 345                 350         
Gln Ile Glu Leu Arg Leu Ala Gly Val Ile Trp Asn Glu Pro Lys Phe 
        355                 360                 365             
Ile Glu Ala Phe Arg Gln Gly Ile Asp Leu His Lys Leu Thr Ala Ser 
    370                 375                 380                 
Ile Leu Phe Asp Lys Asn Ile Glu Glu Val Ser Lys Glu Glu Arg Gln 
385                 390                 395                 400 
Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys 
                405                 410                 415     
Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu 
            420                 425                 430         
Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile 
        435                 440                 445             
Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe 
    450                 455                 460                 
Val Asp Asn Glu Thr Trp Leu Asn Arg Pro Tyr Arg Ala Tyr Lys Pro 
465                 470                 475                 480 
Gln Asp Leu Leu Asn Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe 
                485                 490                 495     
Lys Lys Ala Ile Val Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile 
            500                 505                 510         
Val Asn Leu Val His Asp Glu Ile Val Val Glu Ala Asp Ser Lys Glu 
        515                 520                 525             
Ala Gln Asp Leu Ala Lys Leu Ile Lys Glu Lys Met Glu Glu Ala Trp 
    530                 535                 540                 
Asp Trp Cys Leu Glu Lys Ala Glu Glu Phe Gly Asn Arg Val Ala Lys 
545                 550                 555                 560 
Ile Lys Leu Glu Val Glu Glu Pro Asn Val Gly Asn Thr Trp Glu Lys 
                565                 570                 575     
Pro 
    

<210> 9
<211> 1734
<212> DNA
<213> Artificial Sequence


<220> 
<223> M384 DNA

<400> 9
atgaatgccc cgaaaccgat tctgaaaccg cagccgaagg ccttggttga acctgttctg      60

tgtaatagca ttaatgaaat tccggcaaaa tacaacgagc cgatctattt tgatctggta     120

accgatgaaa atcgtccgac actggcaagc ctgtatcagc cgggctttgg tcgtaaagtt     180

tattgtctga atctgctgcg tgaaaaactg gcacgtttta aagaatggct gctgaaattt     240

agcgaaattc gtggttgggg cttagatttc gatctgcgtg ttctgggtta tacctatgaa     300

cagctgcgta acaaaaaaat cattgatgtt cagctggccc tgaaagtgca gcattatgaa     360

cgctttaaac aaggtggcac caaaggtgaa ggttttcgtc tggatgatgt tgcacgtgat     420

ctgctgggta ttgaatatcc gatgaacaaa accaaaatcc gcgaaacctt caaaaacaac     480

atgtttcaca gctttagcaa cgagcaactg ctgtatgcaa gctttgatgc atatattccg     540

catctgctgt acgaacagct gaccagcagc accctgaata gcctggttta tcagctggat     600

cagcaggcac agaaaattgt tattgaaacc agccagcatg gtatgccggt taaactgaaa     660

gcactggaag aagaaattca tcgtctgacc cagctgcgta gcgaaatgca gaaacaaatt     720

ccgtttaact ataatagccc gaaacagacc gccaaattct ttggtgttaa tagcagcagc     780

aaagatgtgc tgatggatct ggcactgcag ggtaatgaaa tggcaaaaaa agtactggaa     840

gcccgtcaga ttgaaaaaag cctggcattt gcaaaagacc tgtatgatat tgcaaaacgt     900

agcggtggtc gcatttatgg caactttttt accaccaccg caccaagtgg ccgtatgagc     960

tgtagcgata ttaatctgca gcaaattccg cgtcgtctgc gtagctttat tggttttgat    1020

accgaagata aaaaactgat taccgcagat tttccgcaga ttgaactgcg tctggcaggc    1080

gttatttgga atgaaccgaa attcattgaa gcctttcgcc agggtattga tctgcataaa    1140

ctgaccgcta gcattctgtt tgataaaaac attgaagaag tgagcaaaga agaacgccag    1200

attggtaaaa gcgcaaattt tggtctgatt tatggtatca gcccgaaagg ttttgccgaa    1260

tattgtatta gcaacggcat taacatcacc gaagaaatgg caatcgagat cgtgaaaaaa    1320

tggaagaagt tctatcgcaa aatcgccgaa cagcatcagc tggcatatga acgtttcaaa    1380

tatgccgaat tcgtggataa tgaaacctgg ctgaatcgtc cgtatcgtgc atataaaccg    1440

caggacctgc tgaactatca gattcaaggt agcggtgcag aactgttcaa aaaagcaatt    1500

gttctgctga aagaagccaa accggatctg aaaattgtga atctggttca cgatgaaatt    1560

gtggtggaag cagatagtaa agaagcacag gatctggcca aactgatcaa agaaaagatg    1620

gaagaggcat gggattggtg tctggaaaaa gccgaagaat ttggtaatcg tgtggccaaa    1680

atcaaactgg aagttgagga gccgcatgtt ggtaatacct gggaaaaacc gtaa          1734


<210> 10
<211> 577
<212> PRT
<213> Artificial Sequence


<220> 
<223> M384 PRT

<400> 10
Met Asn Ala Pro Lys Pro Ile Leu Lys Pro Gln Pro Lys Ala Leu Val 
1               5                   10                  15      
Glu Pro Val Leu Cys Asn Ser Ile Asn Glu Ile Pro Ala Lys Tyr Asn 
            20                  25                  30          
Glu Pro Ile Tyr Phe Asp Leu Val Thr Asp Glu Asn Arg Pro Thr Leu 
        35                  40                  45              
Ala Ser Leu Tyr Gln Pro Gly Phe Gly Arg Lys Val Tyr Cys Leu Asn 
    50                  55                  60                  
Leu Leu Arg Glu Lys Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe 
65                  70                  75                  80  
Ser Glu Ile Arg Gly Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly 
                85                  90                  95      
Tyr Thr Tyr Glu Gln Leu Arg Asn Lys Lys Ile Ile Asp Val Gln Leu 
            100                 105                 110         
Ala Leu Lys Val Gln His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys 
        115                 120                 125             
Gly Glu Gly Phe Arg Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile 
    130                 135                 140                 
Glu Tyr Pro Met Asn Lys Thr Lys Ile Arg Glu Thr Phe Lys Asn Asn 
145                 150                 155                 160 
Met Phe His Ser Phe Ser Asn Glu Gln Leu Leu Tyr Ala Ser Phe Asp 
                165                 170                 175     
Ala Tyr Ile Pro His Leu Leu Tyr Glu Gln Leu Thr Ser Ser Thr Leu 
            180                 185                 190         
Asn Ser Leu Val Tyr Gln Leu Asp Gln Gln Ala Gln Lys Ile Val Ile 
        195                 200                 205             
Glu Thr Ser Gln His Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu 
    210                 215                 220                 
Glu Ile His Arg Leu Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile 
225                 230                 235                 240 
Pro Phe Asn Tyr Asn Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val 
                245                 250                 255     
Asn Ser Ser Ser Lys Asp Val Leu Met Asp Leu Ala Leu Gln Gly Asn 
            260                 265                 270         
Glu Met Ala Lys Lys Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu 
        275                 280                 285             
Ala Phe Ala Lys Asp Leu Tyr Asp Ile Ala Lys Arg Ser Gly Gly Arg 
    290                 295                 300                 
Ile Tyr Gly Asn Phe Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser 
305                 310                 315                 320 
Cys Ser Asp Ile Asn Leu Gln Gln Ile Pro Arg Arg Leu Arg Ser Phe 
                325                 330                 335     
Ile Gly Phe Asp Thr Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro 
            340                 345                 350         
Gln Ile Glu Leu Arg Leu Ala Gly Val Ile Trp Asn Glu Pro Lys Phe 
        355                 360                 365             
Ile Glu Ala Phe Arg Gln Gly Ile Asp Leu His Lys Leu Thr Ala Ser 
    370                 375                 380                 
Ile Leu Phe Asp Lys Asn Ile Glu Glu Val Ser Lys Glu Glu Arg Gln 
385                 390                 395                 400 
Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys 
                405                 410                 415     
Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu 
            420                 425                 430         
Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile 
        435                 440                 445             
Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe 
    450                 455                 460                 
Val Asp Asn Glu Thr Trp Leu Asn Arg Pro Tyr Arg Ala Tyr Lys Pro 
465                 470                 475                 480 
Gln Asp Leu Leu Asn Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe 
                485                 490                 495     
Lys Lys Ala Ile Val Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile 
            500                 505                 510         
Val Asn Leu Val His Asp Glu Ile Val Val Glu Ala Asp Ser Lys Glu 
        515                 520                 525             
Ala Gln Asp Leu Ala Lys Leu Ile Lys Glu Lys Met Glu Glu Ala Trp 
    530                 535                 540                 
Asp Trp Cys Leu Glu Lys Ala Glu Glu Phe Gly Asn Arg Val Ala Lys 
545                 550                 555                 560 
Ile Lys Leu Glu Val Glu Glu Pro His Val Gly Asn Thr Trp Glu Lys 
                565                 570                 575     
Pro 
    

<210> 11
<211> 1734
<212> DNA
<213> Artificial Sequence


<220> 
<223> M392 DNA

<400> 11
atgaataccc cgaaaccgat tctgaaaccg caaccgaagg ccttggttga acctgttctg      60

tgtgatagca ttgatgaaat tccggcaaaa tacaatgaac ctgtgtattt tgatctggca     120

accgatgaag atagaccggt tctggcaagc atttatcagc cgcattttga acgtaaagtg     180

tattgtctga atctgctgaa agaaaaagtg gcacgcttta aagattggct gctgaaattt     240

agcgaaattc gtggttgggg cttagatttc gatctgcgtg ttctgggtta tacctatgaa     300

cagctgcgta acaaaaaaat cattgatgtt cagctggccc tgaaagtgca gcattatgaa     360

cgctttaaac aaggtggcac caaaggtgaa ggttttcgtc tggatgatgt tgcacgtgat     420

ctgctgggta ttgaatatcc gatgaataaa accaaaattc gcgaaacctt taaaaacaat     480

atgtttcata gctttagcaa tgaacagctg ctgtatgcaa gcctggatgc atacattccg     540

catctgctgt atgaacagct gaccagcagc accctgaata gcctggttta tcagctggat     600

cagcaggcac agaaagttgt tattgaaact agtcagcatg gtatgtcggt taaactgaaa     660

gccctggaag aagaaattca tcgtctgacc cagctgcgtt cagaaatgca gcgtcagatt     720

ccgtttaact ataatagccc gaaacagacc gcaaaattct ttggtgttga tagcagcagc     780

aaagatgttc tgatggatct ggcactgcgt ggtaatgaag ttgccaaaaa agttctggaa     840

gcacgccaga ttgaaaaaag tctggcattc gccaaagatc tgtatgatat cgccaaaaaa     900

aacggtggtc gcatctatgg taactttttt accaccaccg caccgagcgg tcgtatgagc     960

tgtagcgata ttaacctgca gcaaattccg cgtcgtctgc gtccgtttat tggttttgaa    1020

accgaagata aaaagctgat caccgcagat tttccgcaga ttgaactgcg tctggcaggc    1080

gttatttggg atgaaccgaa atttatcgaa gcatttcgtc agggtatcga tctgcataaa    1140

ctgaccgcaa gcattctgtt cgataaaaac attgaagagg tgagcaaaga agaacgccag    1200

attggtaaaa gcgcaaattt tggtctgatc tatggtatca gcccgaaagg ttttgccgaa    1260

tattgtatta gcaacggcat taacatcacc gaagaaatgg caatcgagat cgtgaaaaaa    1320

tggaagaagt tctatcgcaa aatcgccgaa cagcatcagc tggcatatga acgtttcaaa    1380

tatgccgaat tcgtggataa tgaaacctgg ctgaatcgtc cgtatcgtgc atataaaccg    1440

caggacctgc tgaactatca gattcaaggt agcggtgcag aactgttcaa aaaagcaatt    1500

gtgctgctga aagaaaccaa accggatctg aaaattgtga atctggtgca tgatgaaatt    1560

gtggttgaag ccgatagcaa agaagcacag gatctggcaa aactgattaa agaaaaaatg    1620

gaagaagcct gggattggtg tctggaaaaa gccgaagaat ttggtaatcg tgtggccaaa    1680

atcaaactgg aagttgagga gccgcatgtt ggtaatacct gggaaaaacc gtaa          1734


<210> 12
<211> 577
<212> PRT
<213> Artificial Sequence


<220> 
<223> M392 PRT

<400> 12
Met Asn Thr Pro Lys Pro Ile Leu Lys Pro Gln Pro Lys Ala Leu Val 
1               5                   10                  15      
Glu Pro Val Leu Cys Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn 
            20                  25                  30          
Glu Pro Val Tyr Phe Asp Leu Ala Thr Asp Glu Asp Arg Pro Val Leu 
        35                  40                  45              
Ala Ser Ile Tyr Gln Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn 
    50                  55                  60                  
Leu Leu Lys Glu Lys Val Ala Arg Phe Lys Asp Trp Leu Leu Lys Phe 
65                  70                  75                  80  
Ser Glu Ile Arg Gly Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly 
                85                  90                  95      
Tyr Thr Tyr Glu Gln Leu Arg Asn Lys Lys Ile Ile Asp Val Gln Leu 
            100                 105                 110         
Ala Leu Lys Val Gln His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys 
        115                 120                 125             
Gly Glu Gly Phe Arg Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile 
    130                 135                 140                 
Glu Tyr Pro Met Asn Lys Thr Lys Ile Arg Glu Thr Phe Lys Asn Asn 
145                 150                 155                 160 
Met Phe His Ser Phe Ser Asn Glu Gln Leu Leu Tyr Ala Ser Leu Asp 
                165                 170                 175     
Ala Tyr Ile Pro His Leu Leu Tyr Glu Gln Leu Thr Ser Ser Thr Leu 
            180                 185                 190         
Asn Ser Leu Val Tyr Gln Leu Asp Gln Gln Ala Gln Lys Val Val Ile 
        195                 200                 205             
Glu Thr Ser Gln His Gly Met Ser Val Lys Leu Lys Ala Leu Glu Glu 
    210                 215                 220                 
Glu Ile His Arg Leu Thr Gln Leu Arg Ser Glu Met Gln Arg Gln Ile 
225                 230                 235                 240 
Pro Phe Asn Tyr Asn Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val 
                245                 250                 255     
Asp Ser Ser Ser Lys Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn 
            260                 265                 270         
Glu Val Ala Lys Lys Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu 
        275                 280                 285             
Ala Phe Ala Lys Asp Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg 
    290                 295                 300                 
Ile Tyr Gly Asn Phe Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser 
305                 310                 315                 320 
Cys Ser Asp Ile Asn Leu Gln Gln Ile Pro Arg Arg Leu Arg Pro Phe 
                325                 330                 335     
Ile Gly Phe Glu Thr Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro 
            340                 345                 350         
Gln Ile Glu Leu Arg Leu Ala Gly Val Ile Trp Asp Glu Pro Lys Phe 
        355                 360                 365             
Ile Glu Ala Phe Arg Gln Gly Ile Asp Leu His Lys Leu Thr Ala Ser 
    370                 375                 380                 
Ile Leu Phe Asp Lys Asn Ile Glu Glu Val Ser Lys Glu Glu Arg Gln 
385                 390                 395                 400 
Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys 
                405                 410                 415     
Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu 
            420                 425                 430         
Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile 
        435                 440                 445             
Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe 
    450                 455                 460                 
Val Asp Asn Glu Thr Trp Leu Asn Arg Pro Tyr Arg Ala Tyr Lys Pro 
465                 470                 475                 480 
Gln Asp Leu Leu Asn Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe 
                485                 490                 495     
Lys Lys Ala Ile Val Leu Leu Lys Glu Thr Lys Pro Asp Leu Lys Ile 
            500                 505                 510         
Val Asn Leu Val His Asp Glu Ile Val Val Glu Ala Asp Ser Lys Glu 
        515                 520                 525             
Ala Gln Asp Leu Ala Lys Leu Ile Lys Glu Lys Met Glu Glu Ala Trp 
    530                 535                 540                 
Asp Trp Cys Leu Glu Lys Ala Glu Glu Phe Gly Asn Arg Val Ala Lys 
545                 550                 555                 560 
Ile Lys Leu Glu Val Glu Glu Pro His Val Gly Asn Thr Trp Glu Lys 
                565                 570                 575     
Pro 
    

<210> 13
<211> 2631
<212> DNA
<213> Artificial Sequence


<220> 
<223> M160-nuc DNA

<400> 13
atgcgtggta tgcttccact gtttgaaccg aaaggccgtg tgctgctggt tgatggccac      60

catctggcct atcgtacctt ccatgcgctg aaaggcctga cgaccagccg cggcgaaccg     120

gtgcaggcgg tgtatggctt tgcgaaaagc ctgctgaaag cgctgaaaga agatggcgat     180

gcggttattg tggtgtttga tgcgaaagcg ccgagctttc gtcatgaagc gtatggcggc     240

tataaagcgg gtcgtgcgcc gaccccggaa gattttccgc gtcagctggc cctgattaaa     300

gaactggtgg atctgctggg cctggcgcgt ctggaagtgc cgggctatga agcggatgat     360

gtgctggcca gcctggccaa aaaagcggaa aaagaaggct acgaagttcg tattctgacc     420

gccgataaag acctgtatca gctgctgtct gatcgtattc atgtgctgca tcctgagggt     480

tatctgatta ccccggcgtg gctgtgggaa aaatatggcc tgcgtccgga tcagtgggcg     540

gattatcgtg cgctgaccgg cgatgaaagc gataacctgc cgggcgtgaa aggcattggc     600

gaaaaaaccg cgcgtaaact gctggaagaa tggggcagcc tggaagcgct gctgaaaaac     660

ctggatcgtc tgaaaccggc gattcgtgaa aagatcttag cgcacatgga tgatctgaaa     720

ctgagctggg atctggccaa agtgcgtacc gatctgccgc tggaagtgga ttttgcgaaa     780

cgtcgtgaac cggatcgtga acgtctgcgt gcgtttctgg aacgtctgga atttggcagc     840

ctgctgcatg aatttggcct gctggaaagc ggtggcggcg gttctggcgg tggtggcagc     900

aataccccga aaccgattct gaaaccgcag agcaaagcac tggttgaacc tgttctgtgt     960

gatagcattg atgaaattcc ggcaaaatac aatgaacctg tgtattttga tctggcaacc    1020

gatgaagatc gtccggttct ggcaagcatt tatcagccgc attttgaacg taaagtgtat    1080

tgtctgaatc tgctgcgtga aaaactggca cgttttaaag aatggctgct gaaatttagc    1140

gaaattcgtg gttggggctt agatttcgat ctgcgtgttc tgggttatac ctatgaacag    1200

ctgcgcaaca aaaaaatcgt tgacgtccag ctggccatta aagtgcagca ttatgaacgc    1260

tttaaacaag gtggcaccaa aggtgaaggt tttcgtctgg atgatgttgc acgtgatctg    1320

ctgggtattg aatatccgat gaacaaaacg aaaatccgca ccaccttcaa gtataacatg    1380

tatagcagct tttcgtacga gcaactgctg tatgcaagcc tggatgcata tattccgcat    1440

ctgctgtacg aacgtctgag cagcgatacc ctgaatagcc tggtttatca gattgatcaa    1500

gaggttcaga aagtggtgat tgaaaccagc cagcatggta tgccggttaa actgaaagca    1560

ctggaagaag aaattcatcg tctgacccag ctgcgtagcg aaatgcagaa acaaattccg    1620

tttaactata atagcccgaa acagaccgcc aaattctttg gtgttaatag cagcagcaaa    1680

gatgttctga tggatctggc actgcgtggt aatgaagttg ccaaaaaagt tctggaagca    1740

cgccagattg aaaaaagtct ggcattcgcc aaagatctgt atgatatcgc caaaaaaaac    1800

ggtggtcgca tctatggtaa cttttttacc accaccgcac cgagcggtcg tatgagctgt    1860

agcgatatta acctgcagca aattccgcgt cgtctgcgtc cgtttattgg ttttgaaacc    1920

gaggacaaaa aactgatcac cgcagatttt ccgcagattg aactgcgtct ggcaggcgtt    1980

atgtggaatg aacctgaatt tctgaaagcc tttcgtgatg gcattgatct gcacaaactg    2040

accgcaagta ttctgttcga taaaaagatt aacgaagtga gcaaagagga acgccagatc    2100

ggtaaaagcg caaattttgg tctgatttat ggtatcagcc cgaaaggttt tgccgaatat    2160

tgtattagca acggcattaa catcaccgaa gaaatggcaa tcgagatcgt gaaaaaatgg    2220

aagaagttct atcgcaaaat cgccgaacag catcagctgg catatgaacg tttcaaatat    2280

gccgaattcg tggataatga aacctggctg aatcgtccgt atcgtgcatg gaaaccgcaa    2340

gatctgctga actatcagat tcaaggtagc ggtgcagaac tgttcaaaaa agcaattgtt    2400

ctgctgaaag aagccaaacc ggatctgaaa attgtgaatc tggttcacga tgaaattgtg    2460

gtggaaacca gtaccgaaga agcagaagat attgcactgc tggtgaaaca aaagatggaa    2520

gaggcatggg attattgcct ggaaaaagca aaagaatttg gcaataacgt ggccgacatt    2580

aaactggaag ttgaaaaacc gaatattagc agcgtgtggg aaaaagaata a             2631


<210> 14
<211> 876
<212> PRT
<213> Artificial Sequence


<220> 
<223> M160-nuc PRT

<400> 14
Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      
Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          
Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              
Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  
Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  
Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      
Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         
Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             
Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 
Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 
Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     
Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         
Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             
Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 
Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 
Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     
Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         
Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             
Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Thr Pro Lys 
    290                 295                 300                 
Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val Glu Pro Val Leu Cys 
305                 310                 315                 320 
Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn Glu Pro Val Tyr Phe 
                325                 330                 335     
Asp Leu Ala Thr Asp Glu Asp Arg Pro Val Leu Ala Ser Ile Tyr Gln 
            340                 345                 350         
Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn Leu Leu Arg Glu Lys 
        355                 360                 365             
Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe Ser Glu Ile Arg Gly 
    370                 375                 380                 
Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly Tyr Thr Tyr Glu Gln 
385                 390                 395                 400 
Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu Ala Ile Lys Val Gln 
                405                 410                 415     
His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys Gly Glu Gly Phe Arg 
            420                 425                 430         
Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile Glu Tyr Pro Met Asn 
        435                 440                 445             
Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn Met Tyr Ser Ser Phe 
    450                 455                 460                 
Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp Ala Tyr Ile Pro His 
465                 470                 475                 480 
Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu Asn Ser Leu Val Tyr 
                485                 490                 495     
Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile Glu Thr Ser Gln His 
            500                 505                 510         
Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu Glu Ile His Arg Leu 
        515                 520                 525             
Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn 
    530                 535                 540                 
Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser Lys 
545                 550                 555                 560 
Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn Glu Val Ala Lys Lys 
                565                 570                 575     
Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu Ala Phe Ala Lys Asp 
            580                 585                 590         
Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg Ile Tyr Gly Asn Phe 
        595                 600                 605             
Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser Cys Ser Asp Ile Asn 
    610                 615                 620                 
Leu Gln Gln Ile Pro Arg Arg Leu Arg Pro Phe Ile Gly Phe Glu Thr 
625                 630                 635                 640 
Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro Gln Ile Glu Leu Arg 
                645                 650                 655     
Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe Leu Lys Ala Phe Arg 
            660                 665                 670         
Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser Ile Leu Phe Asp Lys 
        675                 680                 685             
Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln Ile Gly Lys Ser Ala 
    690                 695                 700                 
Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys Gly Phe Ala Glu Tyr 
705                 710                 715                 720 
Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu Met Ala Ile Glu Ile 
                725                 730                 735     
Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile Ala Glu Gln His Gln 
            740                 745                 750         
Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe Val Asp Asn Glu Thr 
        755                 760                 765             
Trp Leu Asn Arg Pro Tyr Arg Ala Trp Lys Pro Gln Asp Leu Leu Asn 
    770                 775                 780                 
Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe Lys Lys Ala Ile Val 
785                 790                 795                 800 
Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile Val Asn Leu Val His 
                805                 810                 815     
Asp Glu Ile Val Val Glu Thr Ser Thr Glu Glu Ala Glu Asp Ile Ala 
            820                 825                 830         
Leu Leu Val Lys Gln Lys Met Glu Glu Ala Trp Asp Tyr Cys Leu Glu 
        835                 840                 845             
Lys Ala Lys Glu Phe Gly Asn Asn Val Ala Asp Ile Lys Leu Glu Val 
    850                 855                 860                 
Glu Lys Pro Asn Ile Ser Ser Val Trp Glu Lys Glu 
865                 870                 875     

<210> 15
<211> 588
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of GenBank AFN99405.1

<400> 15
Met Gly Glu Asp Gly Leu Ser Leu Pro Lys Met Met Asn Thr Pro Lys 
1               5                   10                  15      
Pro Ile Leu Lys Pro Gln Pro Lys Ala Leu Val Glu Pro Val Leu Cys 
            20                  25                  30          
Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn Glu Pro Val Tyr Phe 
        35                  40                  45              
Asp Leu Ala Thr Asp Glu Asp Arg Pro Val Leu Ala Ser Ile Tyr Gln 
    50                  55                  60                  
Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn Leu Leu Lys Glu Lys 
65                  70                  75                  80  
Val Ala Arg Phe Lys Asp Trp Leu Leu Lys Phe Ser Glu Ile Arg Gly 
                85                  90                  95      
Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly Tyr Thr Tyr Glu Gln 
            100                 105                 110         
Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu Ala Ile Lys Val Gln 
        115                 120                 125             
His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys Gly Glu Gly Phe Arg 
    130                 135                 140                 
Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile Glu Tyr Pro Met Asn 
145                 150                 155                 160 
Lys Thr Lys Ile Arg Glu Thr Phe Lys Asn Asn Met Phe His Ser Phe 
                165                 170                 175     
Ser Asn Glu Gln Leu Leu Tyr Ala Ser Leu Asp Ala Tyr Ile Pro His 
            180                 185                 190         
Leu Leu Tyr Glu Gln Leu Thr Ser Ser Thr Leu Asn Ser Leu Val Tyr 
        195                 200                 205             
Gln Leu Asp Gln Gln Ala Gln Lys Val Val Ile Glu Thr Ser Gln His 
    210                 215                 220                 
Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu Glu Ile His Arg Leu 
225                 230                 235                 240 
Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn 
                245                 250                 255     
Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser Lys 
            260                 265                 270         
Asp Val Leu Met Asp Leu Ala Leu Gln Gly Asn Glu Met Ala Lys Lys 
        275                 280                 285             
Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu Ala Phe Ala Lys Asp 
    290                 295                 300                 
Leu Tyr Asp Ile Ala Lys Arg Ser Gly Gly Arg Ile Tyr Gly Asn Phe 
305                 310                 315                 320 
Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser Cys Ser Asp Ile Asn 
                325                 330                 335     
Leu Gln Gln Ile Pro Arg Arg Leu Arg Ser Phe Ile Gly Phe Asp Thr 
            340                 345                 350         
Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro Gln Ile Glu Leu Arg 
        355                 360                 365             
Leu Ala Gly Val Ile Trp Asn Glu Pro Lys Phe Ile Glu Ala Phe Arg 
    370                 375                 380                 
Gln Gly Ile Asp Leu His Lys Leu Thr Ala Ser Ile Leu Phe Asp Lys 
385                 390                 395                 400 
Asn Ile Glu Glu Val Ser Lys Glu Glu Arg Gln Ile Gly Lys Ser Ala 
                405                 410                 415     
Asn Phe Gly Leu Ile Tyr Gly Ile Ala Pro Lys Gly Phe Ala Glu Tyr 
            420                 425                 430         
Cys Ile Ala Asn Gly Ile Asn Met Thr Glu Glu Gln Ala Tyr Glu Ile 
        435                 440                 445             
Val Arg Lys Trp Lys Lys Tyr Tyr Thr Lys Ile Ala Glu Gln His Gln 
    450                 455                 460                 
Val Ala Tyr Glu Arg Phe Lys Tyr Asn Glu Tyr Val Asp Asn Glu Thr 
465                 470                 475                 480 
Trp Leu Asn Arg Thr Tyr Arg Ala Trp Lys Pro Gln Asp Leu Leu Asn 
                485                 490                 495     
Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe Lys Lys Ala Ile Val 
            500                 505                 510         
Leu Leu Lys Glu Thr Lys Pro Asp Leu Lys Ile Val Asn Leu Val His 
        515                 520                 525             
Asp Glu Ile Val Val Glu Ala Asp Ser Lys Glu Ala Gln Asp Leu Ala 
    530                 535                 540                 
Lys Leu Ile Lys Glu Lys Met Glu Glu Ala Trp Asp Trp Cys Leu Glu 
545                 550                 555                 560 
Lys Ala Glu Glu Phe Gly Asn Arg Val Ala Lys Ile Lys Leu Glu Val 
                565                 570                 575     
Glu Glu Pro His Val Gly Asn Thr Trp Glu Lys Pro 
            580                 585             

<210> 16
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> 231-260 region

<400> 16
Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn Ser 
1               5                   10                  15      
Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser 
            20                  25                  30  

<210> 17
<211> 73
<212> PRT
<213> Artificial Sequence


<220> 
<223> 400-472 region

<400> 17
Gln Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro 
1               5                   10                  15      
Lys Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu 
            20                  25                  30          
Glu Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys 
        35                  40                  45              
Ile Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu 
    50                  55                  60                  
Phe Val Asp Asn Glu Thr Trp Leu Asn 
65                  70              

<210> 18
<211> 577
<212> PRT
<213> Artificial Sequence


<220> 
<223> Parent 1

<400> 18
Met Asn Thr Pro Lys Pro Ile Leu Lys Pro Gln Pro Lys Ala Leu Val 
1               5                   10                  15      
Glu Pro Val Leu Cys Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn 
            20                  25                  30          
Glu Pro Val Tyr Phe Asp Leu Ala Thr Asp Glu Asp Arg Pro Val Leu 
        35                  40                  45              
Ala Ser Ile Tyr Gln Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn 
    50                  55                  60                  
Leu Leu Lys Glu Lys Val Ala Arg Phe Lys Asp Trp Leu Leu Lys Phe 
65                  70                  75                  80  
Ser Glu Ile Arg Gly Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly 
                85                  90                  95      
Tyr Thr Tyr Glu Gln Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu 
            100                 105                 110         
Ala Ile Lys Val Gln His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys 
        115                 120                 125             
Gly Glu Gly Phe Arg Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile 
    130                 135                 140                 
Glu Tyr Pro Met Asn Lys Thr Lys Ile Arg Glu Thr Phe Lys Asn Asn 
145                 150                 155                 160 
Met Phe His Ser Phe Ser Asn Glu Gln Leu Leu Tyr Ala Ser Leu Asp 
                165                 170                 175     
Ala Tyr Ile Pro His Leu Leu Tyr Glu Gln Leu Thr Ser Ser Thr Leu 
            180                 185                 190         
Asn Ser Leu Val Tyr Gln Leu Asp Gln Gln Ala Gln Lys Val Val Ile 
        195                 200                 205             
Glu Thr Ser Gln His Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu 
    210                 215                 220                 
Glu Ile His Arg Leu Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile 
225                 230                 235                 240 
Pro Phe Asn Tyr Asn Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val 
                245                 250                 255     
Asn Ser Ser Ser Lys Asp Val Leu Met Asp Leu Ala Leu Gln Gly Asn 
            260                 265                 270         
Glu Met Ala Lys Lys Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu 
        275                 280                 285             
Ala Phe Ala Lys Asp Leu Tyr Asp Ile Ala Lys Arg Ser Gly Gly Arg 
    290                 295                 300                 
Ile Tyr Gly Asn Phe Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser 
305                 310                 315                 320 
Cys Ser Asp Ile Asn Leu Gln Gln Ile Pro Arg Arg Leu Arg Ser Phe 
                325                 330                 335     
Ile Gly Phe Asp Thr Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro 
            340                 345                 350         
Gln Ile Glu Leu Arg Leu Ala Gly Val Ile Trp Asn Glu Pro Lys Phe 
        355                 360                 365             
Ile Glu Ala Phe Arg Gln Gly Ile Asp Leu His Lys Leu Thr Ala Ser 
    370                 375                 380                 
Ile Leu Phe Asp Lys Asn Ile Glu Glu Val Ser Lys Glu Glu Arg Gln 
385                 390                 395                 400 
Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ala Pro Lys 
                405                 410                 415     
Gly Phe Ala Glu Tyr Cys Ile Ala Asn Gly Ile Asn Met Thr Glu Glu 
            420                 425                 430         
Gln Ala Tyr Glu Ile Val Arg Lys Trp Lys Lys Tyr Tyr Thr Lys Ile 
        435                 440                 445             
Ala Glu Gln His Gln Val Ala Tyr Glu Arg Phe Lys Tyr Asn Glu Tyr 
    450                 455                 460                 
Val Asp Asn Glu Thr Trp Leu Asn Arg Thr Tyr Arg Ala Trp Lys Pro 
465                 470                 475                 480 
Gln Asp Leu Leu Asn Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe 
                485                 490                 495     
Lys Lys Ala Ile Val Leu Leu Lys Glu Thr Lys Pro Asp Leu Lys Ile 
            500                 505                 510         
Val Asn Leu Val His Asp Glu Ile Val Val Glu Ala Asp Ser Lys Glu 
        515                 520                 525             
Ala Gln Asp Leu Ala Lys Leu Ile Lys Glu Lys Met Glu Glu Ala Trp 
    530                 535                 540                 
Asp Trp Cys Leu Glu Lys Ala Glu Glu Phe Gly Asn Arg Val Ala Lys 
545                 550                 555                 560 
Ile Lys Leu Glu Val Glu Glu Pro His Val Gly Asn Thr Trp Glu Lys 
                565                 570                 575     
Pro 
    

<210> 19
<211> 577
<212> PRT
<213> Artificial Sequence


<220> 
<223> Parent 2

<400> 19
Met Asn Thr Phe Ser Val Lys Thr Lys Ser Glu Pro Lys Ser Leu Val 
1               5                   10                  15      
Glu Pro Val Leu Cys Asn Ser Ile Asn Glu Ile Pro Ala Arg Phe Asp 
            20                  25                  30          
Glu Val Ile Tyr Phe Asp Leu Ala Thr Asp Glu Asn Arg Pro Thr Leu 
        35                  40                  45              
Ala Ser Leu Tyr Gln Pro Ser Phe Gly Arg Lys Val Tyr Cys Leu Asn 
    50                  55                  60                  
Leu Leu Lys Glu Asn Pro Glu Arg Phe Lys Glu Trp Leu Leu Lys Phe 
65                  70                  75                  80  
Pro Glu Ile Arg Gly Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly 
                85                  90                  95      
Phe Thr Tyr Glu Gln Leu Lys Asn Lys Lys Ile Val Asp Val Gln Leu 
            100                 105                 110         
Ala Ile Lys Val Gln Tyr Tyr Glu Arg Phe Lys Gln Asn Gly Ala Lys 
        115                 120                 125             
Gly Glu Gly Phe Arg Leu Asp Asp Val Ala Lys Asp Leu Leu Gly Ile 
    130                 135                 140                 
Glu Tyr Pro Met Asn Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn 
145                 150                 155                 160 
Met Tyr Ser Ser Phe Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp 
                165                 170                 175     
Ala Tyr Ile Pro His Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu 
            180                 185                 190         
Asn Ser Leu Val Tyr Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile 
        195                 200                 205             
Glu Thr Ser Gln His Gly Met Pro Val Lys Leu Gln Ala Leu Glu Glu 
    210                 215                 220                 
Glu Ile His Arg Leu Ile Gln Leu Arg Asn Gln Met Gln Lys Glu Ile 
225                 230                 235                 240 
Pro Phe Asn Tyr Asn Ser Pro Lys Gln Thr Ala Lys Leu Phe Gly Ile 
                245                 250                 255     
Asp Ser Ser Ser Lys Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn 
            260                 265                 270         
Glu Val Ala Lys Lys Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu 
        275                 280                 285             
Ala Phe Ala Lys Asp Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg 
    290                 295                 300                 
Ile Tyr Gly Asn Phe Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser 
305                 310                 315                 320 
Cys Ser Asp Ile Asn Leu Gln Gln Ile Pro Arg Arg Leu Arg Gln Phe 
                325                 330                 335     
Ile Gly Phe Glu Thr Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro 
            340                 345                 350         
Gln Ile Glu Leu Arg Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe 
        355                 360                 365             
Leu Lys Ala Phe Arg Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser 
    370                 375                 380                 
Ile Leu Phe Asp Lys Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln 
385                 390                 395                 400 
Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys 
                405                 410                 415     
Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu 
            420                 425                 430         
Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile 
        435                 440                 445             
Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe 
    450                 455                 460                 
Val Asp Asn Glu Thr Trp Leu Asn Arg Pro Tyr Arg Ala Tyr Lys Pro 
465                 470                 475                 480 
Gln Asp Leu Leu Asn Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe 
                485                 490                 495     
Lys Lys Ala Ile Ile Leu Leu Lys Glu Thr Lys Pro Asp Leu Lys Leu 
            500                 505                 510         
Val Asn Leu Val His Asp Glu Ile Val Val Glu Thr Ser Thr Glu Glu 
        515                 520                 525             
Ala Glu Asp Ile Ala Leu Leu Val Lys Gln Lys Met Glu Glu Ala Trp 
    530                 535                 540                 
Asp Tyr Cys Leu Glu Lys Ala Lys Glu Phe Gly Asn Asn Val Ala Asp 
545                 550                 555                 560 
Ile Lys Leu Glu Val Glu Lys Pro Asn Ile Ser Ser Val Trp Glu Lys 
                565                 570                 575     
Glu 
    

<210> 20
<211> 576
<212> PRT
<213> Artificial Sequence


<220> 
<223> Parent 3

<400> 20
Met Asn Thr Pro Lys Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val 
1               5                   10                  15      
Glu Pro Val Leu Cys Asn Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn 
            20                  25                  30          
Glu Pro Ile Tyr Phe Asp Leu Ala Thr Asp Glu Asp Arg Pro Val Leu 
        35                  40                  45              
Ala Ser Ile Tyr Gln Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn 
    50                  55                  60                  
Leu Leu Arg Glu Lys Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe 
65                  70                  75                  80  
Ser Glu Ile Arg Gly Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly 
                85                  90                  95      
Tyr Thr Tyr Glu Gln Leu Arg Asn Lys Lys Ile Ile Asp Val Gln Leu 
            100                 105                 110         
Ala Leu Lys Val Gln His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys 
        115                 120                 125             
Gly Glu Gly Phe Arg Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile 
    130                 135                 140                 
Glu Tyr Pro Met Asn Lys Thr Lys Ile Arg Glu Thr Phe Lys Asn Asn 
145                 150                 155                 160 
Met Phe His Ser Phe Ser Asn Glu Gln Leu Leu Tyr Ala Ser Phe Asp 
                165                 170                 175     
Ala Tyr Ile Pro His Leu Leu Tyr Glu Gln Leu Thr Ser Ser Thr Leu 
            180                 185                 190         
Asn Ser Leu Val Tyr Gln Leu Asp Gln Gln Ala Gln Lys Ile Val Ile 
        195                 200                 205             
Glu Thr Ser Gln His Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu 
    210                 215                 220                 
Glu Ile His Arg Leu Thr Gln Leu Arg Ser Glu Met Gln Arg Gln Ile 
225                 230                 235                 240 
Pro Phe Asn Tyr Asn Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val 
                245                 250                 255     
Asp Ser Ser Ser Lys Asp Val Leu Met Asp Leu Ala Leu Gln Gly Asn 
            260                 265                 270         
Glu Met Ala Lys Lys Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu 
        275                 280                 285             
Thr Phe Ala Lys Glu Leu Tyr Asp Leu Ala Lys Lys Asn Gly Arg Ile 
    290                 295                 300                 
Tyr Gly Asn Phe Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser Cys 
305                 310                 315                 320 
Ser Asp Ile Asn Leu Gln Gln Ile Pro Arg Arg Leu Arg Pro Phe Ile 
                325                 330                 335     
Gly Phe Glu Thr Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro Gln 
            340                 345                 350         
Ile Glu Leu Arg Leu Ala Gly Val Ile Trp Asp Glu Pro Lys Phe Ile 
        355                 360                 365             
Glu Ala Phe Arg Gln Gly Ile Asp Leu His Lys Leu Thr Ala Ser Ile 
    370                 375                 380                 
Leu Phe Asp Lys Asn Ile Glu Glu Val Ser Lys Glu Glu Arg Gln Ile 
385                 390                 395                 400 
Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ala Pro Lys Gly 
                405                 410                 415     
Phe Ala Glu Tyr Cys Ile Thr Asn Gly Ile Asn Met Thr Glu Glu Gln 
            420                 425                 430         
Ala Tyr Glu Ile Val Lys Lys Trp Lys Arg Tyr Tyr Thr Lys Ile Thr 
        435                 440                 445             
Glu Gln His Gln Val Ala Tyr Glu Arg Phe Lys Tyr Asn Glu Tyr Val 
    450                 455                 460                 
Asp Asn Glu Thr Trp Leu Ala Arg Thr Tyr Arg Ala Tyr Lys Pro Gln 
465                 470                 475                 480 
Asp Leu Leu Asn Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe Lys 
                485                 490                 495     
Lys Ala Ile Val Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile Val 
            500                 505                 510         
Asn Leu Val His Asp Glu Ile Val Val Glu Ala Asp Ser Lys Glu Ala 
        515                 520                 525             
Gln Asp Leu Ala Lys Leu Ile Lys Glu Lys Met Glu Glu Ala Trp Asp 
    530                 535                 540                 
Trp Cys Leu Glu Lys Ala Glu Glu Phe Gly Asn Arg Val Ala Lys Ile 
545                 550                 555                 560 
Lys Leu Glu Val Glu Glu Pro Asn Val Gly Asn Thr Trp Glu Lys Pro 
                565                 570                 575     



<210> 21
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino terminus

<220> 
<221> VARIANT
<222> 3
<223> Xaa is Ala or Thr

<220> 
<221> VARIANT
<222> 12
<223> Xaa is Pro or Ser

<220> 
<221> VARIANT
<222> 22
<223> Xaa is Asn or Asp

<220> 
<221> VARIANT
<222> 25
<223> Xaa is Asn or Asp

<400> 21
Met Asn Xaa Pro Lys Pro Ile Leu Lys Pro Gln Xaa Lys Ala Leu Val 
1               5                   10                  15      
Glu Pro Val Leu Cys Xaa Ser Ile Xaa Glu Ile Pro Ala 
            20                  25                  

<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 22
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  

<210> 23
<211> 3569
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of GenBank V00642.1

<400> 23
gggtgggacc cctttcgggg tcctgctcaa cttcctgtcg agctaatgcc atttttaatg       60

tctttagcga gacgctacca tggctatcgc tgtaggtagc cggaattcca ttcctaggag      120

gtttgacctg tgcgagcttt tagtaccctt gatagggaga acgagacctt cgtcccctcc      180

gttcgcgttt acgcggacgg tgagactgaa gataactcat tctctttaaa atatcgttcg      240

aactggactc ccggtcgttt taactcgact ggggccaaaa cgaaacagtg gcactacccc      300

tctccgtatt cacggggggc gttaagtgtc acatcgatag atcaaggtgc ctacaagcga      360

agtgggtcat cgtggggtcg cccgtacgag gagaaagccg gtttcggctt ctccctcgac      420

gcacgctcct gctacagcct cttccctgta agccaaaact tgacttacat cgaagtgccg      480

cagaacgttg cgaaccgggc gtcgaccgaa gtcctgcaaa aggtcaccca gggtaatttt      540

aaccttggtg ttgctttagc agaggccagg tcgacagcct cacaactcgc gacgcaaacc      600

attgcgctcg tgaaggcgta cactgccgct cgtcgcggta attggcgcca ggcgctccgc      660

taccttgccc taaacgaaga tcgaaagttt cgatcaaaac acgtggccgg caggtggttg      720

gagttgcagt tcggttggtt accactaatg agtgatatcc agggtgcata tgagatgctt      780

acgaaggttc accttcaaga gtttcttcct atgagagccg tacgtcaggt cggtactaac      840

atcaagttag atggccgtct gtcgtatcca gctgcaaact tccagacaac gtgcaacata      900

tcgcgacgta tcgtgatatg gttttacata aacgatgcac gtttggcatg gttgtcgtct      960

ctaggtatct tgaacccact aggtatagtg tgggaaaagg tgcctttctc attcgttgtc     1020

gactggctcc tacctgtagg taacatgctc gagggcctta cggcccccgt gggatgctcc     1080

tacatgtcag gaacagttac tgacgtaata acgggtgagt ccatcataag cgttgacgct     1140

ccctacgggt ggactgtgga gagacagggc actgctaagg cccaaatctc agccatgcat     1200

cgaggggtac aatccgtatg gccaacaact ggcgcgtacg taaagtctcc tttctcgatg     1260

gtccatacct tagatgcgtt agcattaatc aggcaacggc tctctagata gagccctcaa     1320

ccggagtttg aagcatggct tctaacttta ctcagttcgt tctcgtcgac aatggcggaa     1380

ctggcgacgt gactgtcgcc ccaagcaact tcgctaacgg ggtcgctgaa tggatcagct     1440

ctaactcgcg ttcacaggct tacaaagtaa cctgtagcgt tcgtcagagc tctgcgcaga     1500

atcgcaaata caccatcaaa gtcgaggtgc ctaaagtggc aacccagact gttggtggtg     1560

tagagcttcc tgtagccgca tggcgttcgt acttaaatat ggaactaacc attccaattt     1620

tcgctacgaa ttccgactgc gagcttattg ttaaggcaat gcaaggtctc ctaaaagatg     1680

gaaacccgat tccctcagca atcgcagcaa actccggcat ctactaatag acgccggcca     1740

ttcaaacatg aggattaccc atgtcgaaga caacaaagaa gttcaactct ttatgtattg     1800

atcttcctcg cgatctttct ctcgaaattt accaatcaat tgcttctgtc gctactggaa     1860

gcggtgatcc gcacagtgac gactttacag caattgctta cttaagggac gaattgctca     1920

caaagcatcc gaccttaggt tctggtaatg acgaggcgac ccgtcgtacc ttagctatcg     1980

ctaagctacg ggaggcgaat ggtgatcgcg gtcagataaa tagagaaggt ttcttacatg     2040

acaaatcctt gtcatgggat ccggatgttt tacaaaccag catccgtagc cttattggca     2100

acctcctctc tggctaccga tcgtcgttgt ttgggcaatg cacgttctcc aacggtgctc     2160

ctatggggca caagttgcag gatgcagcgc cttacaagaa gttcgctgaa caagcaaccg     2220

ttaccccccg cgctctgaga gcggctctat tggtccgaga ccaatgtgcg ccgtggatca     2280

gacacgcggt ccgctataac gagtcatatg aatttaggct cgttgtaggg aacggagtgt     2340

ttacagttcc gaagaataat aaaatagatc gggctgcctg taaggagcct gatatgaata     2400

tgtacctcca gaaaggggtc ggtgctttca tcagacgccg gctcaaatcc gttggtatag     2460

acctgaatga tcaatcgatc aaccagcgtc tggctcagca gggcagcgta gatggttcgc     2520

ttgcgacgat agacttatcg tctgcatccg attccatctc cgatcgcctg gtgtggagtt     2580

ttctcccacc agagctatat tcatatctcg atcgtatccg ctcacactac ggaatcgtag     2640

atggcgagac gatacgatgg gaactatttt ccacaatggg aaatgggttc acatttgagc     2700

tagagtccat gatattctgg gcaatagtca aagcgaccca aatccatttt ggtaacgccg     2760

gaaccatagg catctacggg gacgatatta tatgtcccag tgagattgca ccccgtgtgc     2820

tagaggcact tgcctactac ggttttaaac cgaatcttcg taaaacgttc gtgtccgggc     2880

tctttcgcga gagctgcggc gcgcactttt accgtggtgt cgatgtcaaa ccgttttaca     2940

tcaagaaacc tgttgacaat ctcttcgccc tgatgctgat attaaatcgg ctacggggtt     3000

ggggagttgt cggaggtatg tcagatccac gcctctataa ggtgtgggta cggctctcct     3060

cccaggtgcc ttcgatgttc ttcggtggga cggacctcgc tgccgactac tacgtagtca     3120

gcccgcctac ggcagtctcg gtatacacca agactccgta cgggcggctg ctcgcggata     3180

cccgtacctc gggtttccgt cttgctcgta tcgctcgaga acgcaagttc ttcagcgaaa     3240

agcacgacag tggtcgctac atagcgtggt tccatactgg aggtgaaatc accgacagca     3300

tgaagtccgc cggcgtgcgc gttatacgca cttcggagtg gctaacgccg gttcccacat     3360

tccctcagga gtgtgggcca gcgagctctc ctcggtagct gaccgaggga cccccgtaaa     3420

cggggtgggt gtgctcgaaa gagcacgggt gcgaaagcgg tccggctcca ccgaaaggtg     3480

ggcgggcttc ggcccaggga cctcccccta aagagaggac ccgggattct cccgatttgg     3540

taactagctg cttggctagt taccaccca                                       3569


<210> 24
<211> 2226
<212> DNA
<213> Homo sapiens


<220> 
<223> Sequence of GenBank NM_005566.3

<400> 24
gtctgccggt cggttgtctg gctgcgcgcg ccacccgggc ctctccagtg ccccgcctgg      60

ctcggcatcc acccccagcc cgactcacac gtgggttccc gcacgtccgc cggccccccc     120

cgctgacgtc agcatagctg ttccacttaa ggcccctccc gcgcccagct cagagtgctg     180

cagccgctgc cgccgattcc ggatctcatt gccacgcgcc cccgacgacc gcccgacgtg     240

cattcccgat tccttttggt tccaagtcca atatggcaac tctaaaggat cagctgattt     300

ataatcttct aaaggaagaa cagacccccc agaataagat tacagttgtt ggggttggtg     360

ctgttggcat ggcctgtgcc atcagtatct taatgaagga cttggcagat gaacttgctc     420

ttgttgatgt catcgaagac aaattgaagg gagagatgat ggatctccaa catggcagcc     480

ttttccttag aacaccaaag attgtctctg gcaaagacta taatgtaact gcaaactcca     540

agctggtcat tatcacggct ggggcacgtc agcaagaggg agaaagccgt cttaatttgg     600

tccagcgtaa cgtgaacatc tttaaattca tcattcctaa tgttgtaaaa tacagcccga     660

actgcaagtt gcttattgtt tcaaatccag tggatatctt gacctacgtg gcttggaaga     720

taagtggttt tcccaaaaac cgtgttattg gaagcggttg caatctggat tcagcccgat     780

tccgttacct aatgggggaa aggctgggag ttcacccatt aagctgtcat gggtgggtcc     840

ttggggaaca tggagattcc agtgtgcctg tatggagtgg aatgaatgtt gctggtgtct     900

ctctgaagac tctgcaccca gatttaggga ctgataaaga taaggaacag tggaaagagg     960

ttcacaagca ggtggttgag agtgcttatg aggtgatcaa actcaaaggc tacacatcct    1020

gggctattgg actctctgta gcagatttgg cagagagtat aatgaagaat cttaggcggg    1080

tgcacccagt ttccaccatg attaagggtc tttacggaat aaaggatgat gtcttcctta    1140

gtgttccttg cattttggga cagaatggaa tctcagacct tgtgaaggtg actctgactt    1200

ctgaggaaga ggcccgtttg aagaagagtg cagatacact ttgggggatc caaaaggagc    1260

tgcaatttta aagtcttctg atgtcatatc atttcactgt ctaggctaca acaggattct    1320

aggtggaggt tgtgcatgtt gtccttttta tctgatctgt gattaaagca gtaatatttt    1380

aagatggact gggaaaaaca tcaactcctg aagttagaaa taagaatggt ttgtaaaatc    1440

cacagctata tcctgatgct ggatggtatt aatcttgtgt agtcttcaac tggttagtgt    1500

gaaatagttc tgccacctct gacgcaccac tgccaatgct gtacgtactg catttgcccc    1560

ttgagccagg tggatgttta ccgtgtgtta tataacttcc tggctccttc actgaacatg    1620

cctagtccaa cattttttcc cagtgagtca catcctggga tccagtgtat aaatccaata    1680

tcatgtcttg tgcataattc ttccaaagga tcttattttg tgaactatat cagtagtgta    1740

cattaccata taatgtaaaa agatctacat acaaacaatg caaccaacta tccaagtgtt    1800

ataccaacta aaacccccaa taaaccttga acagtgacta ctttggttaa ttcattatat    1860

taagatataa agtcataaag ctgctagtta ttatattaat ttggaaatat taggctattc    1920

ttgggcaacc ctgcaacgat tttttctaac agggatatta ttgactaata gcagaggatg    1980

taatagtcaa ctgagttgta ttggtaccac ttccattgta agtcccaaag tattatatat    2040

ttgataataa tgctaatcat aattggaaag taacattcta tatgtaaatg taaaatttat    2100

ttgccaactg aatataggca atgatagtgt gtcactatag ggaacacaga tttttgagat    2160

cttgtcctct ggaagctggt aacaattaaa aacaatctta aggcagggaa aaaaaaaaaa    2220

aaaaaa                                                               2226


<210> 25
<211> 1471
<212> DNA
<213> Vibrio natriegens


<220> 
<223> Sequence of GenBank NR_117890.1

<400> 25
attgaacgct ggcggcaggc ctaacacatg caagtcgagc ggaaacgagt taactgaacc      60

ttcgggggac gttaacggcg tcgagcggcg gacgggtgag taatgcctag gaaattgccc     120

tgatgtgggg gataaccatt ggaaacgatg gctaataccg catgatgcct acgggccaaa     180

gagggggacc ttcgggcctc tcgcgtcagg atatgcctag gtgggattag ctagttggtg     240

aggtaagggc tcaccaaggc gacgatccct agctggtctg agaggatgat cagccacact     300

ggaactgaga cacggtccag actcctacgg gaggcagcag tggggaatat tgcacaatgg     360

gcgcaagcct gatgcagcca tgccgcgtgt gtgaagaagg ccttcgggtt gtaaagcact     420

ttcagtcgtg aggaaggtag tgtagttaat agctgcatta tttgacgtta gcgacagaag     480

aagcaccggc taactccgtg ccagcagccg cggtaatacg gagggtgcga gcgttaatcg     540

gaattactgg gcgtaaagcg catgcaggtg gtttgttaag tcagatgtga aagcccgggg     600

ctcaacctcg gaatagcatt tgaaactggc agactagagt actgtagagg ggggtagaat     660

ttcaggtgta gcggtgaaat gcgtagagat ctgaaggaat accggtggcg aaggcggccc     720

cctggacaga tactgacact cagatgcgaa agcgtgggga gcaaacagga ttagataccc     780

tggtagtcca cgccgtaaac gatgtctact tggaggttgt ggccttgagc cgtggctttc     840

ggagctaacg cgttaagtag accgcctggg gagtacggtc gcaagattaa aactcaaatg     900

aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgatgc aacgcgaaga     960

accttaccta ctcttgacat ccagagaact ttccagagat ggattggtgc cttcgggaac    1020

tctgagacag gtgctgcatg gctgtcgtca gctcgtgttg tgaaatgttg ggttaagtcc    1080

cgcaacgagc gcaaccctta tccttgtttg ccagcgagta atgtcgggaa ctccagggag    1140

actgccggtg ataaaccgga ggaaggtggg gacgacgtca agtcatcatg gcccttacga    1200

gtagggctac acacgtgcta caatggcgca tacagagggc ggccaacttg cgaaagtgag    1260

cgaatcccaa aaagtgcgtc gtagtccgga ttggagtctg caactcgact ccatgaagtc    1320

ggaatcgcta gtaatcgtgg atcagaatgc cacggtgaat acgttcccgg gccttgtaca    1380

caccgcccgt cacaccatgg gagtgggctg caaaagaagt aggtagttta accttcgggg    1440

ggacgcttac cactttgtgg ttcatgactg g                                   1471


<210> 26
<211> 73
<212> PRT
<213> Artificial Sequence


<220> 
<223> Parent 1 of Figure 2A

<400> 26
Gln Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ala Pro 
1               5                   10                  15      
Lys Gly Phe Ala Glu Tyr Cys Ile Ala Asn Gly Ile Asn Met Thr Glu 
            20                  25                  30          
Glu Gln Ala Tyr Glu Ile Val Arg Lys Trp Lys Lys Tyr Tyr Thr Lys 
        35                  40                  45              
Ile Ala Glu Gln His Gln Val Ala Tyr Glu Arg Phe Lys Tyr Asn Glu 
    50                  55                  60                  
Tyr Val Asp Asn Glu Thr Trp Leu Asn 
65                  70              

<210> 27
<211> 73
<212> PRT
<213> Artificial Sequence


<220> 
<223> Parent 2 of Figure 2A

<400> 27
Gln Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro 
1               5                   10                  15      
Lys Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu 
            20                  25                  30          
Glu Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys 
        35                  40                  45              
Ile Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu 
    50                  55                  60                  
Phe Val Asp Asn Glu Thr Trp Leu Asn 
65                  70              

<210> 28
<211> 73
<212> PRT
<213> Artificial Sequence


<220> 
<223> Parent 3 of Figure 2A

<400> 28
Gln Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ala Pro 
1               5                   10                  15      
Lys Gly Phe Ala Glu Tyr Cys Ile Thr Asn Gly Ile Asn Met Thr Glu 
            20                  25                  30          
Glu Gln Ala Tyr Glu Ile Val Lys Lys Trp Lys Arg Tyr Tyr Thr Lys 
        35                  40                  45              
Ile Thr Glu Gln His Gln Val Ala Tyr Glu Arg Phe Lys Tyr Asn Glu 
    50                  55                  60                  
Tyr Val Asp Asn Glu Thr Trp Leu Ala 
65                  70              

<210> 29
<211> 73
<212> PRT
<213> Artificial Sequence


<220> 
<223> M180_PRT of Figure 2A

<400> 29
Gln Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro 
1               5                   10                  15      
Lys Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu 
            20                  25                  30          
Glu Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys 
        35                  40                  45              
Ile Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu 
    50                  55                  60                  
Phe Val Asp Asn Glu Thr Trp Leu Asn 
65                  70              

<210> 30
<211> 73
<212> PRT
<213> Artificial Sequence


<220> 
<223> M384_PRT of Figure 2A

<400> 30
Gln Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro 
1               5                   10                  15      
Lys Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu 
            20                  25                  30          
Glu Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys 
        35                  40                  45              
Ile Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu 
    50                  55                  60                  
Phe Val Asp Asn Glu Thr Trp Leu Asn 
65                  70              

<210> 31
<211> 73
<212> PRT
<213> Artificial Sequence


<220> 
<223> M392_PRT of Figure 2A

<400> 31
Gln Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro 
1               5                   10                  15      
Lys Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu 
            20                  25                  30          
Glu Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys 
        35                  40                  45              
Ile Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu 
    50                  55                  60                  
Phe Val Asp Asn Glu Thr Trp Leu Asn 
65                  70              

<210> 32
<211> 73
<212> PRT
<213> Artificial Sequence


<220> 
<223> M295_PRT of Figure 2A

<400> 32
Gln Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro 
1               5                   10                  15      
Lys Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu 
            20                  25                  30          
Glu Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys 
        35                  40                  45              
Ile Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu 
    50                  55                  60                  
Phe Val Asp Asn Glu Thr Trp Leu Asn 
65                  70              

<210> 33
<211> 73
<212> PRT
<213> Artificial Sequence


<220> 
<223> M66_PRT of Figure 2A

<400> 33
Gln Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro 
1               5                   10                  15      
Lys Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu 
            20                  25                  30          
Glu Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys 
        35                  40                  45              
Ile Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu 
    50                  55                  60                  
Phe Val Asp Asn Glu Thr Trp Leu Asn 
65                  70              

<210> 34
<211> 73
<212> PRT
<213> Artificial Sequence


<220> 
<223> M160_PRT of Figure 2A

<400> 34
Gln Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro 
1               5                   10                  15      
Lys Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu 
            20                  25                  30          
Glu Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys 
        35                  40                  45              
Ile Ala Glu Gln His Gln Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu 
    50                  55                  60                  
Phe Val Asp Asn Glu Thr Trp Leu Asn 
65                  70              

<210> 35
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> Parent 1 of Figure 2B

<400> 35
Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn Ser 
1               5                   10                  15      
Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser 
            20                  25                  30  

<210> 36
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> Parent 2 of Figure 2B

<400> 36
Gln Leu Arg Asn Gln Met Gln Lys Glu Ile Pro Phe Asn Tyr Asn Ser 
1               5                   10                  15      
Pro Lys Gln Thr Ala Lys Leu Phe Gly Ile Asp Ser Ser Ser 
            20                  25                  30  

<210> 37
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> Parent 3 of Figure 2B

<400> 37
Gln Leu Arg Ser Glu Met Gln Arg Gln Ile Pro Phe Asn Tyr Asn Ser 
1               5                   10                  15      
Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asp Ser Ser Ser 
            20                  25                  30  

<210> 38
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> M180_PRT of Figure 2B

<400> 38
Gln Leu Arg Ser Glu Met Gln Arg Gln Ile Pro Phe Asn Tyr Asn Ser 
1               5                   10                  15      
Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asp Ser Ser Ser 
            20                  25                  30  

<210> 39
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> M384_PRT of Figure 2B

<400> 39
Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn Ser 
1               5                   10                  15      
Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser 
            20                  25                  30  

<210> 40
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> M392_PRT of Figure 2B

<400> 40
Gln Leu Arg Ser Glu Met Gln Arg Gln Ile Pro Phe Asn Tyr Asn Ser 
1               5                   10                  15      
Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asp Ser Ser Ser 
            20                  25                  30  

<210> 41
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> M295_PRT of Figure 2B

<400> 41
Gln Leu Arg Ser Glu Met Gln Arg Gln Ile Pro Phe Asn Tyr Asn Ser 
1               5                   10                  15      
Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asp Ser Ser Ser 
            20                  25                  30  

<210> 42
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> M66_PRT of Figure 2B

<400> 42
Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn Ser 
1               5                   10                  15      
Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser 
            20                  25                  30  

<210> 43
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> M160_PRT of Figure 2B

<400> 43
Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn Ser 
1               5                   10                  15      
Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser 
            20                  25                  30  

<210> 44
<211> 2628
<212> DNA
<213> Artificial Sequence


<220> 
<223> M401 DNA

<400> 44
atgcgtggta tgcttccact gtttgaaccg aaaggccgtg tgctgctggt tgatggccac      60

catctggcct atcgtacctt ccatgcgctg aaaggcctga cgaccagccg cggcgaaccg     120

gtgcaggcgg tgtatggctt tgcgaaaagc ctgctgaaag cgctgaaaga agatggcgat     180

gcggttattg tggtgtttga tgcgaaagcg ccgagctttc gtcatgaagc gtatggcggc     240

tataaagcgg gtcgtgcgcc gaccccggaa gattttccgc gtcagctggc cctgattaaa     300

gaactggtgg atctgctggg cctggcgcgt ctggaagtgc cgggctatga agcggatgat     360

gtgctggcca gcctggccaa aaaagcggaa aaagaaggct acgaagttcg tattctgacc     420

gccgataaag acctgtatca gctgctgtct gatcgtattc atgtgctgca tcctgagggt     480

tatctgatta ccccggcgtg gctgtgggaa aaatatggcc tgcgtccgga tcagtgggcg     540

gattatcgtg cgctgaccgg cgatgaaagc gataacctgc cgggcgtgaa aggcattggc     600

gaaaaaaccg cgcgtaaact gctggaagaa tggggcagcc tggaagcgct gctgaaaaac     660

ctggatcgtc tgaaaccggc gattcgtgaa aagatcttag cgcacatgga tgatctgaaa     720

ctgagctggg atctggccaa agtgcgtacc gatctgccgc tggaagtgga ttttgcgaaa     780

cgtcgtgaac cggatcgtga acgtctgcgt gcgtttctgg aacgtctgga atttggcagc     840

ctgctgcatg aatttggcct gctggaaagc ggtggcggcg gttctggcgg tggtggcagc     900

aataccccga aaccgattct gaaaccgcag agcaaagcac tggttgaacc tgttctgtgt     960

gatagcattg atgaaattcc ggcaaaatac aatgaacctg tgtattttga tctggaaacc    1020

gatgaagatc gtccggttct ggcaagcatt tatcagccgc attttgaacg taaagtgtat    1080

tgtctgaatc tgctgcgtga aaaactggca cgttttaaag aatggctgct gaaatttagc    1140

gaaattcgtg gttggggctt agatttcgat ctgcgtgttc tgggttatac ctatgaacag    1200

ctgcgcaaca aaaaaatcgt tgacgtccag ctggccatta aagtgcagca ttatgaacgc    1260

tttaaacaag gtggcaccaa aggtgaaggt tttcgtctgg atgatgttgc acgtgatctg    1320

ctgggtattg aatatccgat gaacaaaacg aaaatccgca ccaccttcaa gtataacatg    1380

tatagcagct tttcgtacga gcaactgctg tatgcaagcc tggatgcata tattccgcat    1440

ctgctgtacg aacgtctgag cagcgatacc ctgaatagcc tggtttatca gattgatcaa    1500

gaggttcaga aagtggtgat tgaaaccagc cagcatggta tgccggttaa actgaaagca    1560

ctggaagaag aaattcatcg tctgacccag ctgcgtagcg aaatgcagaa acaaattccg    1620

tttaactata atagcccgaa acagaccgcc aaattctttg gtgttaatag cagcagcaaa    1680

gatgttctga tggatctggc actgcgtggt aatgaagttg ccaaaaaagt tctggaagca    1740

cgccagattg aaaaaagtct ggcattcgcc aaagatctgt atgatatcgc caaaaaaaac    1800

ggtggtcgca tctatggtaa cttttttacc accaccgcac cgagcggtcg tatgagctgt    1860

agcgatatta acctgcagca aattccgcgt cgtctgcgtc cgtttattgg ttttgaaacc    1920

gaggacaaaa aactgatcac cgcagatttt ccgcagattg aactgcgtct ggcaggcgtt    1980

atgtggaatg aacctgaatt tctgaaagcc tttcgtgatg gcattgatct gcacaaactg    2040

accgcaagta ttctgttcga taaaaagatt aacgaagtga gcaaagagga acgccagatc    2100

ggtaaaagcg caaattttgg tctgatttat ggtatcagcc cgaaaggttt tgccgaatat    2160

tgtattagca acggcattaa catcaccgaa gaaatggcaa tcgagatcgt gaaaaaatgg    2220

aagaagttct atcgcaaaat cgccgaacag catcagctgg catatgaacg tttcaaatat    2280

gccgaattcg tggataatga aacctggctg aatcgtccgt atcgtgcatg gaaaccgcaa    2340

gatctgctga actatcagat tcaaggtagc ggtgcagaac tgttcaaaaa agcaattgtt    2400

ctgctgaaag aagccaaacc ggatctgaaa attgtgaatc tggttcacga tgaaattgtg    2460

gtggaaacca gtaccgaaga agcagaagat attgcactgc tggtgaaaca aaagatggaa    2520

gaggcatggg attattgcct ggaaaaagca aaagaatttg gcaataacgt ggccgacatt    2580

aaactggaag ttgaaaaacc gaatattagc agcgtgtggg aaaaagaa                 2628


<210> 45
<211> 876
<212> PRT
<213> Artificial Sequence


<220> 
<223> M401 PRT

<400> 45
Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      
Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          
Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              
Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  
Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  
Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      
Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         
Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             
Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 
Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 
Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     
Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         
Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             
Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 
Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 
Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     
Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         
Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             
Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Thr Pro Lys 
    290                 295                 300                 
Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val Glu Pro Val Leu Cys 
305                 310                 315                 320 
Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn Glu Pro Val Tyr Phe 
                325                 330                 335     
Asp Leu Glu Thr Asp Glu Asp Arg Pro Val Leu Ala Ser Ile Tyr Gln 
            340                 345                 350         
Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn Leu Leu Arg Glu Lys 
        355                 360                 365             
Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe Ser Glu Ile Arg Gly 
    370                 375                 380                 
Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly Tyr Thr Tyr Glu Gln 
385                 390                 395                 400 
Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu Ala Ile Lys Val Gln 
                405                 410                 415     
His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys Gly Glu Gly Phe Arg 
            420                 425                 430         
Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile Glu Tyr Pro Met Asn 
        435                 440                 445             
Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn Met Tyr Ser Ser Phe 
    450                 455                 460                 
Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp Ala Tyr Ile Pro His 
465                 470                 475                 480 
Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu Asn Ser Leu Val Tyr 
                485                 490                 495     
Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile Glu Thr Ser Gln His 
            500                 505                 510         
Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu Glu Ile His Arg Leu 
        515                 520                 525             
Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn 
    530                 535                 540                 
Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser Lys 
545                 550                 555                 560 
Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn Glu Val Ala Lys Lys 
                565                 570                 575     
Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu Ala Phe Ala Lys Asp 
            580                 585                 590         
Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg Ile Tyr Gly Asn Phe 
        595                 600                 605             
Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser Cys Ser Asp Ile Asn 
    610                 615                 620                 
Leu Gln Gln Ile Pro Arg Arg Leu Arg Pro Phe Ile Gly Phe Glu Thr 
625                 630                 635                 640 
Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro Gln Ile Glu Leu Arg 
                645                 650                 655     
Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe Leu Lys Ala Phe Arg 
            660                 665                 670         
Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser Ile Leu Phe Asp Lys 
        675                 680                 685             
Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln Ile Gly Lys Ser Ala 
    690                 695                 700                 
Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys Gly Phe Ala Glu Tyr 
705                 710                 715                 720 
Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu Met Ala Ile Glu Ile 
                725                 730                 735     
Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile Ala Glu Gln His Gln 
            740                 745                 750         
Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe Val Asp Asn Glu Thr 
        755                 760                 765             
Trp Leu Asn Arg Pro Tyr Arg Ala Trp Lys Pro Gln Asp Leu Leu Asn 
    770                 775                 780                 
Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe Lys Lys Ala Ile Val 
785                 790                 795                 800 
Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile Val Asn Leu Val His 
                805                 810                 815     
Asp Glu Ile Val Val Glu Thr Ser Thr Glu Glu Ala Glu Asp Ile Ala 
            820                 825                 830         
Leu Leu Val Lys Gln Lys Met Glu Glu Ala Trp Asp Tyr Cys Leu Glu 
        835                 840                 845             
Lys Ala Lys Glu Phe Gly Asn Asn Val Ala Asp Ile Lys Leu Glu Val 
    850                 855                 860                 
Glu Lys Pro Asn Ile Ser Ser Val Trp Glu Lys Glu 
865                 870                 875     

<210> 46
<211> 2628
<212> DNA
<213> Artificial Sequence


<220> 
<223> M402 DNA

<400> 46
atgcgtggta tgcttccact gtttgaaccg aaaggccgtg tgctgctggt tgatggccac      60

catctggcct atcgtacctt ccatgcgctg aaaggcctga cgaccagccg cggcgaaccg     120

gtgcaggcgg tgtatgactt tgcgaaaagc ctgctgaaag cgctgaaaga agatggcgat     180

gcggttattg tggtgtttga tgcgaaagcg ccgagctttc gtcatgaagc gtatggcggc     240

tataaagcgg gtcgtgcgcc gaccccggaa gattttccgc gtcagctggc cctgattaaa     300

gaactggtgg atctgctggg cctggcgcgt ctggaagtgc cgggctatga agcggatgat     360

gtgctggcca gcctggccaa aaaagcggaa aaagaaggct acgaagttcg tattctgacc     420

gccgataaag acctgtatca gctgctgtct gatcgtattc atgtgctgca tcctgagggt     480

tatctgatta ccccggcgtg gctgtgggaa aaatatggcc tgcgtccgga tcagtgggcg     540

gattatcgtg cgctgaccgg cgatgaaagc gataacctgc cgggcgtgaa aggcattggc     600

gaaaaaaccg cgcgtaaact gctggaagaa tggggcagcc tggaagcgct gctgaaaaac     660

ctggatcgtc tgaaaccggc gattcgtgaa aagatcttag cgcacatgga tgatctgaaa     720

ctgagctggg atctggccaa agtgcgtacc gatctgccgc tggaagtgga ttttgcgaaa     780

cgtcgtgaac cggatcgtga acgtctgcgt gcgtttctgg aacgtctgga atttggcagc     840

ctgctgcatg aatttggcct gctggaaagc ggtggcggcg gttctggcgg tggtggcagc     900

aataccccga aaccgattct gaaaccgcag agcaaagcac tggttgaacc tgttctgtgt     960

gatagcattg atgaaattcc ggcaaaatac aatgaacctg tgtattttga tctggaaacc    1020

gatgaagatc gtccggttct ggcaagcatt tatcagccgc attttgaacg taaagtgtat    1080

tgtctgaatc tgctgcgtga aaaactggca cgttttaaag aatggctgct gaaatttagc    1140

gaaattcgtg gttggggctt agatttcgat ctgcgtgttc tgggttatac ctatgaacag    1200

ctgcgcaaca aaaaaatcgt tgacgtccag ctggccatta aagtgcagca ttatgaacgc    1260

tttaaacaag gtggcaccaa aggtgaaggt tttcgtctgg atgatgttgc acgtgatctg    1320

ctgggtattg aatatccgat gaacaaaacg aaaatccgca ccaccttcaa gtataacatg    1380

tatagcagct tttcgtacga gcaactgctg tatgcaagcc tggatgcata tattccgcat    1440

ctgctgtacg aacgtctgag cagcgatacc ctgaatagcc tggtttatca gattgatcaa    1500

gaggttcaga aagtggtgat tgaaaccagc cagcatggta tgccggttaa actgaaagca    1560

ctggaagaag aaattcatcg tctgacccag ctgcgtagcg aaatgcagaa acaaattccg    1620

tttaactata atagcccgaa acagaccgcc aaattctttg gtgttaatag cagcagcaaa    1680

gatgttctga tggatctggc actgcgtggt aatgaagttg ccaaaaaagt tctggaagca    1740

cgccagattg aaaaaagtct ggcattcgcc aaagatctgt atgatatcgc caaaaaaaac    1800

ggtggtcgca tctatggtaa cttttttacc accaccgcac cgagcggtcg tatgagctgt    1860

agcgatatta acctgcagca aattccgcgt cgtctgcgtc cgtttattgg ttttgaaacc    1920

gaggacaaaa aactgatcac cgcagatttt ccgcagattg aactgcgtct ggcaggcgtt    1980

atgtggaatg aacctgaatt tctgaaagcc tttcgtgatg gcattgatct gcacaaactg    2040

accgcaagta ttctgttcga taaaaagatt aacgaagtga gcaaagagga acgccagatc    2100

ggtaaaagcg caaattttgg tctgatttat ggtatcagcc cgaaaggttt tgccgaatat    2160

tgtattagca acggcattaa catcaccgaa gaaatggcaa tcgagatcgt gaaaaaatgg    2220

aagaagttct atcgcaaaat cgccgaacag catcagctgg catatgaacg tttcaaatat    2280

gccgaattcg tggataatga aacctggctg aatcgtccgt atcgtgcatg gaaaccgcaa    2340

gatctgctga actatcagat tcaaggtagc ggtgcagaac tgttcaaaaa agcaattgtt    2400

ctgctgaaag aagccaaacc ggatctgaaa attgtgaatc tggttcacga tgaaattgtg    2460

gtggaaacca gtaccgaaga agcagaagat attgcactgc tggtgaaaca aaagatggaa    2520

gaggcatggg attattgcct ggaaaaagca aaagaatttg gcaataacgt ggccgacatt    2580

aaactggaag ttgaaaaacc gaatattagc agcgtgtggg aaaaagaa                 2628


<210> 47
<211> 876
<212> PRT
<213> Artificial Sequence


<220> 
<223> M402 PRT

<400> 47
Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      
Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          
Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Asp Phe Ala 
        35                  40                  45              
Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  
Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  
Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      
Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         
Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             
Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 
Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 
Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     
Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         
Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             
Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 
Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 
Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     
Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         
Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             
Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Thr Pro Lys 
    290                 295                 300                 
Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val Glu Pro Val Leu Cys 
305                 310                 315                 320 
Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn Glu Pro Val Tyr Phe 
                325                 330                 335     
Asp Leu Glu Thr Asp Glu Asp Arg Pro Val Leu Ala Ser Ile Tyr Gln 
            340                 345                 350         
Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn Leu Leu Arg Glu Lys 
        355                 360                 365             
Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe Ser Glu Ile Arg Gly 
    370                 375                 380                 
Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly Tyr Thr Tyr Glu Gln 
385                 390                 395                 400 
Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu Ala Ile Lys Val Gln 
                405                 410                 415     
His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys Gly Glu Gly Phe Arg 
            420                 425                 430         
Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile Glu Tyr Pro Met Asn 
        435                 440                 445             
Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn Met Tyr Ser Ser Phe 
    450                 455                 460                 
Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp Ala Tyr Ile Pro His 
465                 470                 475                 480 
Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu Asn Ser Leu Val Tyr 
                485                 490                 495     
Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile Glu Thr Ser Gln His 
            500                 505                 510         
Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu Glu Ile His Arg Leu 
        515                 520                 525             
Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn 
    530                 535                 540                 
Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser Lys 
545                 550                 555                 560 
Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn Glu Val Ala Lys Lys 
                565                 570                 575     
Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu Ala Phe Ala Lys Asp 
            580                 585                 590         
Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg Ile Tyr Gly Asn Phe 
        595                 600                 605             
Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser Cys Ser Asp Ile Asn 
    610                 615                 620                 
Leu Gln Gln Ile Pro Arg Arg Leu Arg Pro Phe Ile Gly Phe Glu Thr 
625                 630                 635                 640 
Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro Gln Ile Glu Leu Arg 
                645                 650                 655     
Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe Leu Lys Ala Phe Arg 
            660                 665                 670         
Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser Ile Leu Phe Asp Lys 
        675                 680                 685             
Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln Ile Gly Lys Ser Ala 
    690                 695                 700                 
Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys Gly Phe Ala Glu Tyr 
705                 710                 715                 720 
Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu Met Ala Ile Glu Ile 
                725                 730                 735     
Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile Ala Glu Gln His Gln 
            740                 745                 750         
Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe Val Asp Asn Glu Thr 
        755                 760                 765             
Trp Leu Asn Arg Pro Tyr Arg Ala Trp Lys Pro Gln Asp Leu Leu Asn 
    770                 775                 780                 
Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe Lys Lys Ala Ile Val 
785                 790                 795                 800 
Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile Val Asn Leu Val His 
                805                 810                 815     
Asp Glu Ile Val Val Glu Thr Ser Thr Glu Glu Ala Glu Asp Ile Ala 
            820                 825                 830         
Leu Leu Val Lys Gln Lys Met Glu Glu Ala Trp Asp Tyr Cys Leu Glu 
        835                 840                 845             
Lys Ala Lys Glu Phe Gly Asn Asn Val Ala Asp Ile Lys Leu Glu Val 
    850                 855                 860                 
Glu Lys Pro Asn Ile Ser Ser Val Trp Glu Lys Glu 
865                 870                 875     

<210> 48
<211> 2628
<212> DNA
<213> Artificial Sequence


<220> 
<223> M403 DNA

<400> 48
atgcgtggta tgcttccact gtttgaaccg aaaggccgtg tgctgctggt tgatggccac      60

catctggcct atcgtacctt ccatgcgctg aaaggcctga cgaccagccg cggcgaaccg     120

gtgcaggcgg tgtatgactt tgcgaaaagc ctgctgaaag cgctgaaaga agatggcgat     180

gcggttattg tggtgtttga tgcgaaagcg ccgagctttc gtcatgaagc gtatggcggc     240

tataaagcgg gtcgtgcgcc gaccccggaa gattttccgc gtcagctggc cctgattaaa     300

gaactggtgg atctgctggg cctggcgcgt ctggaagtgc cgggctatga agcggatgat     360

gtgctggcca gcctggccaa aaaagcggaa aaagaaggct acgaagttcg tattctgacc     420

gccgataaag acctgtatca gctgctgtct gatcgtattc atgtgctgca tcctgagggt     480

tatctgatta ccccggcgtg gctgtgggaa aaatatggcc tgcgtccgga tcagtgggcg     540

gattatcgtg cgctgaccgg cgatgaaagc gataacctgc cgggcgtgaa aggcattggc     600

gaaaaaaccg cgcgtaaact gctggaagaa tggggcagcc tggaagcgct gctgaaaaac     660

ctggatcgtc tgaaaccggc gattcgtgaa aagatcttag cgcacatgga tgatctgaaa     720

ctgagctggg atctggccaa agtgcgtacc gatctgccgc tggaagtgga ttttgcgaaa     780

cgtcgtgaac cggatcgtga acgtctgcgt gcgtttctgg aacgtctgga atttggcagc     840

ctgctgcatg aatttggcct gctggaaagc ggtggcggcg gttctggcgg tggtggcagc     900

aataccccga aaccgattct gaaaccgcag agcaaagcac tggttgaacc tgttctgtgt     960

gatagcattg atgaaattcc ggcaaaatac aatgaacctg tgtattttga tctggcaacc    1020

gatgaagatc gtccggttct ggcaagcatt tatcagccgc attttgaacg taaagtgtat    1080

tgtctgaatc tgctgcgtga aaaactggca cgttttaaag aatggctgct gaaatttagc    1140

gaaattcgtg gttggggctt agatttcgat ctgcgtgttc tgggttatac ctatgaacag    1200

ctgcgcaaca aaaaaatcgt tgacgtccag ctggccatta aagtgcagca ttatgaacgc    1260

tttaaacaag gtggcaccaa aggtgaaggt tttcgtctgg atgatgttgc acgtgatctg    1320

ctgggtattg aatatccgat gaacaaaacg aaaatccgca ccaccttcaa gtataacatg    1380

tatagcagct tttcgtacga gcaactgctg tatgcaagcc tggatgcata tattccgcat    1440

ctgctgtacg aacgtctgag cagcgatacc ctgaatagcc tggtttatca gattgatcaa    1500

gaggttcaga aagtggtgat tgaaaccagc cagcatggta tgccggttaa actgaaagca    1560

ctggaagaag aaattcatcg tctgacccag ctgcgtagcg aaatgcagaa acaaattccg    1620

tttaactata atagcccgaa acagaccgcc aaattctttg gtgttaatag cagcagcaaa    1680

gatgttctga tggatctggc actgcgtggt aatgaagttg ccaaaaaagt tctggaagca    1740

cgccagattg aaaaaagtct ggcattcgcc aaagatctgt atgatatcgc caaaaaaaac    1800

ggtggtcgca tctatggtaa cttttttacc accaccgcac cgagcggtcg tatgagctgt    1860

agcgatatta acctgcagca aattccgcgt cgtctgcgtc cgtttattgg ttttgaaacc    1920

gaggacaaaa aactgatcac cgcagatttt ccgcagattg aactgcgtct ggcaggcgtt    1980

atgtggaatg aacctgaatt tctgaaagcc tttcgtgatg gcattgatct gcacaaactg    2040

accgcaagta ttctgttcga taaaaagatt aacgaagtga gcaaagagga acgccagatc    2100

ggtaaaagcg caaattttgg tctgatttat ggtatcagcc cgaaaggttt tgccgaatat    2160

tgtattagca acggcattaa catcaccgaa gaaatggcaa tcgagatcgt gaaaaaatgg    2220

aagaagttct atcgcaaaat cgccgaacag catcagctgg catatgaacg tttcaaatat    2280

gccgaattcg tggataatga aacctggctg aatcgtccgt atcgtgcatg gaaaccgcaa    2340

gatctgctga actatcagat tcaaggtagc ggtgcagaac tgttcaaaaa agcaattgtt    2400

ctgctgaaag aagccaaacc ggatctgaaa attgtgaatc tggttcacga tgaaattgtg    2460

gtggaaacca gtaccgaaga agcagaagat attgcactgc tggtgaaaca aaagatggaa    2520

gaggcatggg attattgcct ggaaaaagca aaagaatttg gcaataacgt ggccgacatt    2580

aaactggaag ttgaaaaacc gaatattagc agcgtgtggg aaaaagaa                 2628


<210> 49
<211> 876
<212> PRT
<213> Artificial Sequence


<220> 
<223> M403 PRT

<400> 49
Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      
Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          
Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Asp Phe Ala 
        35                  40                  45              
Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  
Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  
Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      
Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         
Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             
Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 
Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 
Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     
Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         
Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             
Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 
Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 
Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     
Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         
Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             
Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Thr Pro Lys 
    290                 295                 300                 
Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val Glu Pro Val Leu Cys 
305                 310                 315                 320 
Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn Glu Pro Val Tyr Phe 
                325                 330                 335     
Asp Leu Ala Thr Asp Glu Asp Arg Pro Val Leu Ala Ser Ile Tyr Gln 
            340                 345                 350         
Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn Leu Leu Arg Glu Lys 
        355                 360                 365             
Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe Ser Glu Ile Arg Gly 
    370                 375                 380                 
Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly Tyr Thr Tyr Glu Gln 
385                 390                 395                 400 
Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu Ala Ile Lys Val Gln 
                405                 410                 415     
His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys Gly Glu Gly Phe Arg 
            420                 425                 430         
Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile Glu Tyr Pro Met Asn 
        435                 440                 445             
Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn Met Tyr Ser Ser Phe 
    450                 455                 460                 
Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp Ala Tyr Ile Pro His 
465                 470                 475                 480 
Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu Asn Ser Leu Val Tyr 
                485                 490                 495     
Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile Glu Thr Ser Gln His 
            500                 505                 510         
Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu Glu Ile His Arg Leu 
        515                 520                 525             
Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn 
    530                 535                 540                 
Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser Lys 
545                 550                 555                 560 
Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn Glu Val Ala Lys Lys 
                565                 570                 575     
Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu Ala Phe Ala Lys Asp 
            580                 585                 590         
Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg Ile Tyr Gly Asn Phe 
        595                 600                 605             
Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser Cys Ser Asp Ile Asn 
    610                 615                 620                 
Leu Gln Gln Ile Pro Arg Arg Leu Arg Pro Phe Ile Gly Phe Glu Thr 
625                 630                 635                 640 
Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro Gln Ile Glu Leu Arg 
                645                 650                 655     
Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe Leu Lys Ala Phe Arg 
            660                 665                 670         
Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser Ile Leu Phe Asp Lys 
        675                 680                 685             
Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln Ile Gly Lys Ser Ala 
    690                 695                 700                 
Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys Gly Phe Ala Glu Tyr 
705                 710                 715                 720 
Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu Met Ala Ile Glu Ile 
                725                 730                 735     
Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile Ala Glu Gln His Gln 
            740                 745                 750         
Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe Val Asp Asn Glu Thr 
        755                 760                 765             
Trp Leu Asn Arg Pro Tyr Arg Ala Trp Lys Pro Gln Asp Leu Leu Asn 
    770                 775                 780                 
Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe Lys Lys Ala Ile Val 
785                 790                 795                 800 
Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile Val Asn Leu Val His 
                805                 810                 815     
Asp Glu Ile Val Val Glu Thr Ser Thr Glu Glu Ala Glu Asp Ile Ala 
            820                 825                 830         
Leu Leu Val Lys Gln Lys Met Glu Glu Ala Trp Asp Tyr Cys Leu Glu 
        835                 840                 845             
Lys Ala Lys Glu Phe Gly Asn Asn Val Ala Asp Ile Lys Leu Glu Val 
    850                 855                 860                 
Glu Lys Pro Asn Ile Ser Ser Val Trp Glu Lys Glu 
865                 870                 875     

<210> 50
<211> 2628
<212> DNA
<213> Artificial Sequence


<220> 
<223> M501 DNA

<400> 50
atgcgtggta tgcttccact gtttgaaccg aaaggccgtg tgctgctggt tgatggccac      60

catctggcct atcgtacctt ccatgcgctg aaaggcctga cgaccagccg cggcgaaccg     120

gtgcaggcgg tgtatggctt tgcgaaaagc ctgctgaaag cgctgaaaga agatggcgat     180

gcggttattg tggtgtttga tgcgaaagcg ccgagctttc gtcatgaagc gtatggcggc     240

tataaagcgg gtcgtgcgcc gaccccggaa gattttccgc gtcagctggc cctgattaaa     300

gaactggtgg atctgctggg cctggcgcgt ctggaagtgc cgggctatga agcggatgat     360

gtgctggcca gcctggccaa aaaagcggaa aaagaaggct acgaagttcg tattctgacc     420

gccgataaag acctgtatca gctgctgtct gatcgtattc atgtgctgca tcctgagggt     480

tatctgatta ccccggcgtg gctgtgggaa aaatatggcc tgcgtccgga tcagtgggcg     540

gattatcgtg cgctgaccgg cgatgaaagc gataacctgc cgggcgtgaa aggcattggc     600

gaaaaaaccg cgcgtaaact gctggaagaa tggggcagcc tggaagcgct gctgaaaaac     660

ctggatcgtc tgaaaccggc gattcgtgaa aagatcttag cgcacatgga tgatctgaaa     720

ctgagctggg atctggccaa agtgcgtacc gatctgccgc tggaagtgga ttttgcgaaa     780

cgtcgtgaac cggatcgtga acgtctgcgt gcgtttctgg aacgtctgga atttggcagc     840

ctgctgcatg aatttggcct gctggaaagc ggtggcggcg gttctggcgg tggtggcagc     900

aataccccga aaccgattct gaaaccgcag agcaaagcac tggttgaacc tgttctgtgt     960

gatagcattg atgaaattcc ggcaaaatac aatgaacctg tgtattttga tctggcaacc    1020

gatgaagatc gtccggttct ggcaagcatt tatcagccgc attttgaacg taaagtgtat    1080

tgtctgaatc tgctgcgtga aaaactggca cgttttaaag aatggctgct gaaatttagc    1140

gaaattcgtg gttggggctt agatttcgat ctgcgtgttc tgggttatac ctatgaacag    1200

ctgcgcaaca aaaaaatcgt tgacgtccag ctggccatta aagtgcagca ttatgaacgc    1260

tttaaacaag gtggcaccaa aggtgaaggt tttcgtctgg atgatgttgc acgtgatctg    1320

ctgggtattg aatatccgat gaacaaaacg aaaatccgca ccaccttcaa gtataacatg    1380

tatagcagct tttcgtacga gcaactgctg tatgcaagcc tggatgcata tattccgcat    1440

ctgctgtacg aacgtctgag cagcgatacc ctgaatagcc tggtttatca gattgatcaa    1500

gaggttcaga aagtggtgat tgaaaccagc cagcatggta tgccggttaa actgaaagca    1560

ctggaagaag aaattcatcg tctgacccag ctgcgtagcg aaatgcagaa acaaattccg    1620

tttaactata atagcccgaa acagaccgcc aaattctttg gtgttaatag cagcagcaaa    1680

gatgttctga tggatctggc actgcgtggt aatgaagttg ccaaaaaagt tctggaagca    1740

cgccagattg aaaaaagtct ggcattcgcc aaagatctgt atgatatcgc caaaaaaaac    1800

ggtggtcgca tctatggtaa cttttttacc accaccgcac cgagcggtcg tatgagctgt    1860

agcgatatta acctgcagca aattccgcgt cgtctgcgtc cgtttattgg ttttgaaacc    1920

gaggacaaaa aactgatcac cgcagatttt ccgcagattg aactgcgtct ggcaggcgtt    1980

atgtggaatg aacctgaatt tctgaaagcc tttcgtgatg gcattgatct gcacaaactg    2040

accgcaagta ttctgttcga taaaaagatt aacgaagtga gcaaagagga acgccagatc    2100

ggtaaaagcg caaattttgg tctgatttat ggtatcagcc cgaaaggttt tgccgaatat    2160

tgtattagca acggcattaa catcaccgaa gaaatggcaa tcgagatcgt gaaaaaatgg    2220

aagaagttct atcgcaaaat cgccgaacag cagaagaagg catatgaacg tttcaaatat    2280

gccgaattcg tggataatga aacctggctg aatcgtccgt atcgtgcatg gaaaccgcaa    2340

gatctgctga actatcagat tcaaggtagc ggtgcagaac tgttcaaaaa agcaattgtt    2400

ctgctgaaag aagccaaacc ggatctgaaa attgtgaatc tagttcacga tgaaattgtg    2460

gtggaaacca gtaccgaaga agcagaagat attgcactgc tggtgaaaca aaagatggaa    2520

gaggcatggg attattgcct ggaaaaagca aaagaatttg gcaataacgt ggccgacatt    2580

aaactggaag ttgaaaaacc gaatattagc agcgtgtggg aaaaagaa                 2628


<210> 51
<211> 876
<212> PRT
<213> Artificial Sequence


<220> 
<223> M501 PRT

<400> 51
Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      
Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          
Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              
Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  
Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  
Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      
Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         
Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             
Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 
Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 
Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     
Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         
Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             
Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 
Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 
Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     
Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         
Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             
Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Thr Pro Lys 
    290                 295                 300                 
Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val Glu Pro Val Leu Cys 
305                 310                 315                 320 
Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn Glu Pro Val Tyr Phe 
                325                 330                 335     
Asp Leu Ala Thr Asp Glu Asp Arg Pro Val Leu Ala Ser Ile Tyr Gln 
            340                 345                 350         
Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn Leu Leu Arg Glu Lys 
        355                 360                 365             
Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe Ser Glu Ile Arg Gly 
    370                 375                 380                 
Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly Tyr Thr Tyr Glu Gln 
385                 390                 395                 400 
Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu Ala Ile Lys Val Gln 
                405                 410                 415     
His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys Gly Glu Gly Phe Arg 
            420                 425                 430         
Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile Glu Tyr Pro Met Asn 
        435                 440                 445             
Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn Met Tyr Ser Ser Phe 
    450                 455                 460                 
Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp Ala Tyr Ile Pro His 
465                 470                 475                 480 
Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu Asn Ser Leu Val Tyr 
                485                 490                 495     
Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile Glu Thr Ser Gln His 
            500                 505                 510         
Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu Glu Ile His Arg Leu 
        515                 520                 525             
Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn 
    530                 535                 540                 
Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser Lys 
545                 550                 555                 560 
Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn Glu Val Ala Lys Lys 
                565                 570                 575     
Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu Ala Phe Ala Lys Asp 
            580                 585                 590         
Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg Ile Tyr Gly Asn Phe 
        595                 600                 605             
Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser Cys Ser Asp Ile Asn 
    610                 615                 620                 
Leu Gln Gln Ile Pro Arg Arg Leu Arg Pro Phe Ile Gly Phe Glu Thr 
625                 630                 635                 640 
Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro Gln Ile Glu Leu Arg 
                645                 650                 655     
Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe Leu Lys Ala Phe Arg 
            660                 665                 670         
Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser Ile Leu Phe Asp Lys 
        675                 680                 685             
Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln Ile Gly Lys Ser Ala 
    690                 695                 700                 
Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys Gly Phe Ala Glu Tyr 
705                 710                 715                 720 
Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu Met Ala Ile Glu Ile 
                725                 730                 735     
Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile Ala Glu Gln Gln Lys 
            740                 745                 750         
Lys Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe Val Asp Asn Glu Thr 
        755                 760                 765             
Trp Leu Asn Arg Pro Tyr Arg Ala Trp Lys Pro Gln Asp Leu Leu Asn 
    770                 775                 780                 
Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe Lys Lys Ala Ile Val 
785                 790                 795                 800 
Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile Val Asn Leu Val His 
                805                 810                 815     
Asp Glu Ile Val Val Glu Thr Ser Thr Glu Glu Ala Glu Asp Ile Ala 
            820                 825                 830         
Leu Leu Val Lys Gln Lys Met Glu Glu Ala Trp Asp Tyr Cys Leu Glu 
        835                 840                 845             
Lys Ala Lys Glu Phe Gly Asn Asn Val Ala Asp Ile Lys Leu Glu Val 
    850                 855                 860                 
Glu Lys Pro Asn Ile Ser Ser Val Trp Glu Lys Glu 
865                 870                 875     

<210> 52
<211> 2628
<212> DNA
<213> Artificial Sequence


<220> 
<223> M502 DNA

<400> 52
atgcgtggta tgcttccact gtttgaaccg aaaggccgtg tgctgctggt tgatggccac      60

catctggcct atcgtacctt ccatgcgctg aaaggcctga cgaccagccg cggcgaaccg     120

gtgcaggcgg tgtatggctt tgcgaaaagc ctgctgaaag cgctgaaaga agatggcgat     180

gcggttattg tggtgtttga tgcgaaagcg ccgagctttc gtcatgaagc gtatggcggc     240

tataaagcgg gtcgtgcgcc gaccccggaa gattttccgc gtcagctggc cctgattaaa     300

gaactggtgg atctgctggg cctggcgcgt ctggaagtgc cgggctatga agcggatgat     360

gtgctggcca gcctggccaa aaaagcggaa aaagaaggct acgaagttcg tattctgacc     420

gccgataaag acctgtatca gctgctgtct gatcgtattc atgtgctgca tcctgagggt     480

tatctgatta ccccggcgtg gctgtgggaa aaatatggcc tgcgtccgga tcagtgggcg     540

gattatcgtg cgctgaccgg cgatgaaagc gataacctgc cgggcgtgaa aggcattggc     600

gaaaaaaccg cgcgtaaact gctggaagaa tggggcagcc tggaagcgct gctgaaaaac     660

ctggatcgtc tgaaaccggc gattcgtgaa aagatcttag cgcacatgga tgatctgaaa     720

ctgagctggg atctggccaa agtgcgtacc gatctgccgc tggaagtgga ttttgcgaaa     780

cgtcgtgaac cggatcgtga acgtctgcgt gcgtttctgg aacgtctgga atttggcagc     840

ctgctgcatg aatttggcct gctggaaagc ggtggcggcg gttctggcgg tggtggcagc     900

aataccccga aaccgattct gaaaccgcag agcaaagcac tggttgaacc tgttctgtgt     960

gatagcattg atgaaattcc ggcaaaatac aatgaacctg tgtattttga tctggcaacc    1020

gatgaagatc gtccggttct ggcaagcatt tatcagccgc attttgaacg taaagtgtat    1080

tgtctgaatc tgctgcgtga aaaactggca cgttttaaag aatggctgct gaaatttagc    1140

gaaattcgtg gttggggctt agatttcgat ctgcgtgttc tgggttatac ctatgaacag    1200

ctgcgcaaca aaaaaatcgt tgacgtccag ctggccatta aagtgcagca ttatgaacgc    1260

tttaaacaag gtggcaccaa aggtgaaggt tttcgtctgg atgatgttgc acgtgatctg    1320

ctgggtattg aatatccgat gaacaaaacg aaaatccgca ccaccttcaa gtataacatg    1380

tatagcagct tttcgtacga gcaactgctg tatgcaagcc tggatgcata tattccgcat    1440

ctgctgtacg aacgtctgag cagcgatacc ctgaatagcc tggtttatca gattgatcaa    1500

gaggttcaga aagtggtgat tgaaaccagc cagcatggta tgccggttaa actgaaagca    1560

ctggaagaag aaattcatcg tctgacccag ctgcgtagcg aaatgcagaa acaaattccg    1620

tttaactata atagcccgaa acagaccgcc aaattctttg gtgttaatag cagcagcaaa    1680

gatgttctga tggatctggc actgcgtggt aatgaagttg ccaaaaaagt tctggaagca    1740

cgccagattg aaaaaagtct ggcattcgcc aaagatctgt atgatatcgc caaaaaaaac    1800

ggtggtcgca tctatggtaa cttttttacc accaccgcac cgagcggtcg tatgagctgt    1860

agcaatatta acctgcagaa cattccgcgt cgtctgcgtc cgtttattgg ttttgaaacc    1920

gaggacaaaa aactgatcac cgcagatttt ccgcagattg aactgcgtct ggcaggcgtt    1980

atgtggaatg aacctgaatt tctgaaagcc tttcgtgatg gcattgatct gcacaaactg    2040

accgcaagta ttctgttcga taaaaagatt aacgaagtga gcaaagagga acgccagatc    2100

ggtaaaagcg caaattttgg tctgatttat ggtatcagcc cgaaaggttt tgccgaatat    2160

tgtattagca acggcattaa catcaccgaa gaaatggcaa tcgagatcgt gaaaaaatgg    2220

aagaagttct atcgcaaaat cgccgaacag catcagctgg catatgaacg tttcaaatat    2280

gccgaattcg tggataatga aacctggctg aatcgtccgt atcgtgcttg caaaccgcaa    2340

gccctgctta actatcagat tcaaggtagc ggtgcagaac tgttcaaaaa agcaattgtt    2400

ctgctgaaag aagccaaacc ggatctgaaa attgtgaatc tggttcacga tgaaattgtg    2460

gtggaaacca gtaccgaaga agcagaagat attgcactgc tggtgaaaca aaagatggaa    2520

gaggcatggg attattgcct ggaaaaagca aaagaatttg gcaataacgt ggccgacatt    2580

aaactggaag ttgaaaaacc gaatattagc agcgtgtggg aaaaagaa                 2628


<210> 53
<211> 876
<212> PRT
<213> Artificial Sequence


<220> 
<223> M502 PRT

<400> 53
Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      
Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          
Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              
Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  
Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  
Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      
Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         
Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             
Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 
Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 
Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     
Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         
Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             
Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 
Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 
Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     
Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         
Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             
Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Thr Pro Lys 
    290                 295                 300                 
Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val Glu Pro Val Leu Cys 
305                 310                 315                 320 
Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn Glu Pro Val Tyr Phe 
                325                 330                 335     
Asp Leu Ala Thr Asp Glu Asp Arg Pro Val Leu Ala Ser Ile Tyr Gln 
            340                 345                 350         
Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn Leu Leu Arg Glu Lys 
        355                 360                 365             
Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe Ser Glu Ile Arg Gly 
    370                 375                 380                 
Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly Tyr Thr Tyr Glu Gln 
385                 390                 395                 400 
Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu Ala Ile Lys Val Gln 
                405                 410                 415     
His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys Gly Glu Gly Phe Arg 
            420                 425                 430         
Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile Glu Tyr Pro Met Asn 
        435                 440                 445             
Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn Met Tyr Ser Ser Phe 
    450                 455                 460                 
Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp Ala Tyr Ile Pro His 
465                 470                 475                 480 
Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu Asn Ser Leu Val Tyr 
                485                 490                 495     
Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile Glu Thr Ser Gln His 
            500                 505                 510         
Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu Glu Ile His Arg Leu 
        515                 520                 525             
Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn 
    530                 535                 540                 
Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser Lys 
545                 550                 555                 560 
Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn Glu Val Ala Lys Lys 
                565                 570                 575     
Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu Ala Phe Ala Lys Asp 
            580                 585                 590         
Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg Ile Tyr Gly Asn Phe 
        595                 600                 605             
Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser Cys Ser Asn Ile Asn 
    610                 615                 620                 
Leu Gln Asn Ile Pro Arg Arg Leu Arg Pro Phe Ile Gly Phe Glu Thr 
625                 630                 635                 640 
Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro Gln Ile Glu Leu Arg 
                645                 650                 655     
Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe Leu Lys Ala Phe Arg 
            660                 665                 670         
Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser Ile Leu Phe Asp Lys 
        675                 680                 685             
Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln Ile Gly Lys Ser Ala 
    690                 695                 700                 
Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys Gly Phe Ala Glu Tyr 
705                 710                 715                 720 
Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu Met Ala Ile Glu Ile 
                725                 730                 735     
Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile Ala Glu Gln His Gln 
            740                 745                 750         
Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe Val Asp Asn Glu Thr 
        755                 760                 765             
Trp Leu Asn Arg Pro Tyr Arg Ala Cys Lys Pro Gln Ala Leu Leu Asn 
    770                 775                 780                 
Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe Lys Lys Ala Ile Val 
785                 790                 795                 800 
Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile Val Asn Leu Val His 
                805                 810                 815     
Asp Glu Ile Val Val Glu Thr Ser Thr Glu Glu Ala Glu Asp Ile Ala 
            820                 825                 830         
Leu Leu Val Lys Gln Lys Met Glu Glu Ala Trp Asp Tyr Cys Leu Glu 
        835                 840                 845             
Lys Ala Lys Glu Phe Gly Asn Asn Val Ala Asp Ile Lys Leu Glu Val 
    850                 855                 860                 
Glu Lys Pro Asn Ile Ser Ser Val Trp Glu Lys Glu 
865                 870                 875     

<210> 54
<211> 2628
<212> DNA
<213> Artificial Sequence


<220> 
<223> M503 DNA

<400> 54
atgcgtggta tgcttccact gtttgaaccg aaaggccgtg tgctgctggt tgatggccac      60

catctggcct atcgtacctt ccatgcgctg aaaggcctga cgaccagccg cggcgaaccg     120

gtgcaggcgg tgtatggctt tgcgaaaagc ctgctgaaag cgctgaaaga agatggcgat     180

gcggttattg tggtgtttga tgcgaaagcg ccgagctttc gtcatgaagc gtatggcggc     240

tataaagcgg gtcgtgcgcc gaccccggaa gattttccgc gtcagctggc cctgattaaa     300

gaactggtgg atctgctggg cctggcgcgt ctggaagtgc cgggctatga agcggatgat     360

gtgctggcca gcctggccaa aaaagcggaa aaagaaggct acgaagttcg tattctgacc     420

gccgataaag acctgtatca gctgctgtct gatcgtattc atgtgctgca tcctgagggt     480

tatctgatta ccccggcgtg gctgtgggaa aaatatggcc tgcgtccgga tcagtgggcg     540

gattatcgtg cgctgaccgg cgatgaaagc gataacctgc cgggcgtgaa aggcattggc     600

gaaaaaaccg cgcgtaaact gctggaagaa tggggcagcc tggaagcgct gctgaaaaac     660

ctggatcgtc tgaaaccggc gattcgtgaa aagatcttag cgcacatgga tgatctgaaa     720

ctgagctggg atctggccaa agtgcgtacc gatctgccgc tggaagtgga ttttgcgaaa     780

cgtcgtgaac cggatcgtga acgtctgcgt gcgtttctgg aacgtctgga atttggcagc     840

ctgctgcatg aatttggcct gctggaaagc ggtggcggcg gttctggcgg tggtggcagc     900

aataccccga aaccgattct gaaaccgcag agcaaagcac tggttgaacc tgttctgtgt     960

gatagcattg atgaaattcc ggcaaaatac aatgaacctg tgtattttga tctggcaacc    1020

gatgaagatc gtccggttct ggcaagcatt tatcagccgc attttgaacg taaagtgtat    1080

tgtctgaatc tgctgcgtga aaaactggca cgttttaaag aatggctgct gaaatttagc    1140

gaaattcgtg gttggggctt agatttcgat ctgcgtgttc tgggttatac ctatgaacag    1200

ctgcgcaaca aaaaaatcgt tgacgtccag ctggccatta aagtgcagca ttatgaacgc    1260

tttaaacaag gtggcaccaa aggtgaaggt tttcgtctgg atgatgttgc acgtgatctg    1320

ctgggtattg aatatccgat gaacaaaacg aaaatccgca ccaccttcaa gtataacatg    1380

tatagcagct tttcgtacga gcaactgctg tatgcaagcc tggatgcata tattccgcat    1440

ctgctgtacg aacgtctgag cagcgatacc ctgaatagcc tggtttatca gattgatcaa    1500

gaggttcaga aagtggtgat tgaaaccagc cagcatggta tgccggttaa actgaaagca    1560

ctggaagaag aaattcatcg tctgacccag ctgcgtagcg aaatgcagaa acaaattccg    1620

tttaactata atagcccgaa acagaccgcc aaattctttg gtgttaatag cagcagcaaa    1680

gatgttctga tggatctggc actgcgtggt aatgaagttg ccaaaaaagt tctggaagca    1740

cgccagattg aaaaaagtct ggcattcgcc aaagatctgt atgatatcgc caaaaaaaac    1800

ggtggtcgca tctatggtaa cttttttacc accaccgcac cgagcggtcg tatgagctgt    1860

agcgatatta acctgcagaa cattccgcgt cgtctgcgtc cgtttattgg ttttgaaacc    1920

gaggacaaaa aactgatcac cgcagatttt ccgcagattg aactgcgtct ggcaggcgtt    1980

atgtggaatg aacctgaatt tctgaaagcc tttcgtgatg gcattgatct gcacaaactg    2040

accgcaagta ttctgttcga taaaaagatt aacgaagtga gcaaagagga acgccagatc    2100

ggtaaaagcg caaattttgg tctgatttat ggtatcagcc cgaaaggttt tgccgaatat    2160

tgtattagca acggcattaa catcaccgaa gaaatggcaa tcgagatcgt gaaaaaatgg    2220

aagaagttct atcgcaaaat cgccgaacag cagaagaagg catatgaacg tttcaaatat    2280

gccgaattcg tggataatga aacctggctg aatcgtccgt atcgtgcatg gaaaccgcaa    2340

gatctgctga actatcagat tcaaggtagc ggtgcagaac tgttcaaaaa agcaattgtt    2400

ctgctgaaag aagccaaacc ggatctgaaa attgtgaatc tggttcacga tgaaattgtg    2460

gtggaaacca gtaccgaaga agcagaagat attgcactgc tggtgaaaca aaagatggaa    2520

gaggcatggg attattgcct ggaaaaagca aaagaatttg gcaataacgt ggccgacatt    2580

aaactggaag ttgaaaaacc gaatattagc agcgtgtggg aaaaagaa                 2628


<210> 55
<211> 876
<212> PRT
<213> Artificial Sequence


<220> 
<223> M503 PRT

<400> 55
Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      
Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          
Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              
Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  
Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  
Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      
Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         
Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             
Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 
Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 
Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     
Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         
Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             
Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 
Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 
Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     
Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         
Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             
Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Thr Pro Lys 
    290                 295                 300                 
Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val Glu Pro Val Leu Cys 
305                 310                 315                 320 
Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn Glu Pro Val Tyr Phe 
                325                 330                 335     
Asp Leu Ala Thr Asp Glu Asp Arg Pro Val Leu Ala Ser Ile Tyr Gln 
            340                 345                 350         
Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn Leu Leu Arg Glu Lys 
        355                 360                 365             
Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe Ser Glu Ile Arg Gly 
    370                 375                 380                 
Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly Tyr Thr Tyr Glu Gln 
385                 390                 395                 400 
Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu Ala Ile Lys Val Gln 
                405                 410                 415     
His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys Gly Glu Gly Phe Arg 
            420                 425                 430         
Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile Glu Tyr Pro Met Asn 
        435                 440                 445             
Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn Met Tyr Ser Ser Phe 
    450                 455                 460                 
Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp Ala Tyr Ile Pro His 
465                 470                 475                 480 
Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu Asn Ser Leu Val Tyr 
                485                 490                 495     
Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile Glu Thr Ser Gln His 
            500                 505                 510         
Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu Glu Ile His Arg Leu 
        515                 520                 525             
Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn 
    530                 535                 540                 
Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser Lys 
545                 550                 555                 560 
Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn Glu Val Ala Lys Lys 
                565                 570                 575     
Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu Ala Phe Ala Lys Asp 
            580                 585                 590         
Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg Ile Tyr Gly Asn Phe 
        595                 600                 605             
Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser Cys Ser Asp Ile Asn 
    610                 615                 620                 
Leu Gln Asn Ile Pro Arg Arg Leu Arg Pro Phe Ile Gly Phe Glu Thr 
625                 630                 635                 640 
Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro Gln Ile Glu Leu Arg 
                645                 650                 655     
Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe Leu Lys Ala Phe Arg 
            660                 665                 670         
Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser Ile Leu Phe Asp Lys 
        675                 680                 685             
Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln Ile Gly Lys Ser Ala 
    690                 695                 700                 
Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys Gly Phe Ala Glu Tyr 
705                 710                 715                 720 
Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu Met Ala Ile Glu Ile 
                725                 730                 735     
Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile Ala Glu Gln Gln Lys 
            740                 745                 750         
Lys Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe Val Asp Asn Glu Thr 
        755                 760                 765             
Trp Leu Asn Arg Pro Tyr Arg Ala Trp Lys Pro Gln Asp Leu Leu Asn 
    770                 775                 780                 
Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe Lys Lys Ala Ile Val 
785                 790                 795                 800 
Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile Val Asn Leu Val His 
                805                 810                 815     
Asp Glu Ile Val Val Glu Thr Ser Thr Glu Glu Ala Glu Asp Ile Ala 
            820                 825                 830         
Leu Leu Val Lys Gln Lys Met Glu Glu Ala Trp Asp Tyr Cys Leu Glu 
        835                 840                 845             
Lys Ala Lys Glu Phe Gly Asn Asn Val Ala Asp Ile Lys Leu Glu Val 
    850                 855                 860                 
Glu Lys Pro Asn Ile Ser Ser Val Trp Glu Lys Glu 
865                 870                 875     

<210> 56
<211> 1940
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACTB plasmid

<400> 56
gagtgagcgg cgcggggcca atcagcgtgc gccgttccga aagttgcctt ttatggctcg      60

agcggccgcg gcggcgccct ataaaaccca gcggcgcgac gcgccaccac cgccgagacc     120

gcgtccgccc cgcgagcaca gagcctcgcc tttgccgatc cgccgcccgt ccacacccgc     180

cgccagctca ccatggatga tgatatcgcc gcgctcgtcg tcgacaacgg ctccggcatg     240

tgcaaggccg gcttcgcggg cgacgatgcc ccccgggccg tcttcccctc catcgtgggg     300

cgccccaggc accagggcgt gatggtgggc atgggtcaga aggattccta tgtgggcgac     360

gaggcccaga gcaagagagg catcctcacc ctgaagtacc ccatcgagca cggcatcgtc     420

accaactggg acgacatgga gaaaatctgg caccacacct tctacaatga gctgcgtgtg     480

gctcccgagg agcaccccgt gctgctgacc gaggcccccc tgaaccccaa ggccaaccgc     540

gagaagatga cccagatcat gtttgagacc ttcaacaccc cagccatgta cgttgctatc     600

caggctgtgc tatccctgta cgcctctggc cgtaccactg gcatcgtgat ggactccggt     660

gacggggtca cccacactgt gcccatctac gaggggtatg ccctccccca tgccatcctg     720

cgtctggacc tggctggccg ggacctgact gactacctca tgaagatcct caccgagcgc     780

ggctacagct tcaccaccac ggccgagcgg gaaatcgtgc gtgacattaa ggagaagctg     840

tgctacgtcg ccctggactt cgagcaagag atggccacgg ctgcttccag ctcctccctg     900

gagaagagct acgagctgcc tgacggccag gtcatcacca ttggcaatga gcggttccgc     960

tgccctgagg cactcttcca gccttccttc ctgggcatgg agtcctgtgg catccacgaa    1020

actaccttca actccatcat gaagtgtgac gtggacatcc gcaaagacct gtacgccaac    1080

acagtgctgt ctggcggcac caccatgtac cctggcattg ccgacaggat gcagaaggag    1140

atcactgccc tggcacccag cacaatgaag atcaagatca ttgctcctcc tgagcgcaag    1200

tactccgtgt ggatcggcgg ctccatcctg gcctcgctgt ccaccttcca gcagatgtgg    1260

atcagcaagc aggagtatga cgagtccggc ccctccatcg tccaccgcaa atgcttctag    1320

gcggactatg acttagttgc gttacaccct ttcttgacaa aacctaactt gcgcagaaaa    1380

caagatgaga ttggcatggc tttatttgtt ttttttgttt tgttttggtt tttttttttt    1440

ttttggcttg actcaggatt taaaaactgg aacggtgaag gtgacagcag tcggttggag    1500

cgagcatccc ccaaagttca caatgtggcc gaggactttg attgcacatt gttgtttttt    1560

taatagtcat tccaaatatg agatgcgttg ttacaggaag tcccttgcca tcctaaaagc    1620

caccccactt ctctctaagg agaatggccc agtcctctcc caagtccaca caggggaggt    1680

gatagcattg ctttcgtgta aattatgtaa tgcaaaattt ttttaatctt cgccttaata    1740

cttttttatt ttgttttatt ttgaatgatg agccttcgtg cccccccttc cccctttttt    1800

gtcccccaac ttgagatgta tgaaggcttt tggtctccct gggagtgggt ggaggcagcc    1860

agggcttacc tgtacactga cttgagacca gttgaataaa agtgcacacc ttaaaaatga    1920

ggaaaaaaaa aaaaaaaaaa                                                1940


<210> 57
<211> 1242
<212> DNA
<213> Artificial Sequence


<220> 
<223> GAPDH plasmid

<400> 57
gacagccgca tcttcttgtg cagtgccagc ctcgtcccgt agacaaaatg gtgaaggtcg      60

gtgtgaacgg atttggccgt attgggcgcc tggtcaccag ggctgccatt tgcagtggca     120

aagtggagat tgttgccatc aacgacccct tcattgacct caactacatg gtctacatgt     180

tccagtatga ctccactcac ggcaaattca acggcacagt caaggccgag aatgggaagc     240

ttgtcatcaa cgggaagccc atcaccatct tccaggagcg agaccccact aacatcaaat     300

ggggtgaggc cggtgctgag tatgtcgtgg agtctactgg tgtcttcacc accatggaga     360

aggccggggc ccacttgaag ggtggagcca aacgggtcat catctccgcc ccttctgccg     420

atgcccccat gtttgtgatg ggtgtgaacc acgagaaata tgacaactca ctcaagattg     480

tcagcaatgc atcctgcacc accaactgct tagcccccct ggccaaggtc atccatgaca     540

actttggcat tgtggaaggg ctcatgacca cagtccatgc catcactgcc acccagaaga     600

ctgtggatgg cccctctgga aagctgtggc gtgatggccg tggggctgcc cagaacatca     660

tccctgcatc cactggtgct gccaaggctg tgggcaaggt catcccagag ctgaacggga     720

agctcactgg catggccttc cgtgttccta cccccaatgt gtccgtcgtg gatctgacgt     780

gccgcctgga gaaacctgcc aagtatgatg acatcaagaa ggtggtgaag caggcatctg     840

agggcccact gaagggcatc ttgggctaca ctgaggacca ggttgtctcc tgcgacttca     900

acagcaactc ccactcttcc accttcgatg ccggggctgg cattgctctc aatgacaact     960

ttgtcaagct catttcctgg tatgacaatg aatacggcta cagcaacagg gtggtggacc    1020

tcatggccta catggcctcc aaggagtaag aaaccctgga ccacccaccc cagcaaggac    1080

actgagcaag agaggcccta tcccaactcg gcccccaaca ctgagcatct ccctcacaat    1140

ttccatccca gacccccata ataacaggag gggcctaggg agccctccct actctcttga    1200

ataccatcaa taaagttcgc tgcacccaaa aaaaaaaaaa aa                       1242


<210> 58
<211> 1497
<212> DNA
<213> Artificial Sequence


<220> 
<223> ILB1 Plasmid

<400> 58
accaacctct tcgaggcaca aggcacaaca ggctgctctg ggattctctt cagccaatct      60

tcattgctca agtgtctgaa gcagccatgg cagaagtacc tgagctcgcc agtgaaatga     120

tggcttatta cagtggcaat gaggatgact tgttctttga agctgatggc cctaaacaga     180

tgaagtgctc cttccaggac ctggacctct gccctctgga tggcggcatc cagctacgaa     240

tctccgacca ccactacagc aagggcttca ggcaggccgc gtcagttgtt gtggccatgg     300

acaagctgag gaagatgctg gttccctgcc cacagacctt ccaggagaat gacctgagca     360

ccttctttcc cttcatcttt gaagaagaac ctatcttctt cgacacatgg gataacgagg     420

cttatgtgca cgatgcacct gtacgatcac tgaactgcac gctccgggac tcacagcaaa     480

aaagcttggt gatgtctggt ccatatgaac tgaaagctct ccacctccag ggacaggata     540

tggagcaaca agtggtgttc tccatgtcct ttgtacaagg agaagaaagt aatgacaaaa     600

tacctgtggc cttgggcctc aaggaaaaga atctgtacct gtcctgcgtg ttgaaagatg     660

ataagcccac tctacagctg gagagtgtag atcccaaaaa ttacccaaag aagaagatgg     720

aaaagcgatt tgtcttcaac aagatagaaa tcaataacaa gctggaattt gagtctgccc     780

agttccccaa ctggtacatc agcacctctc aagcagaaaa catgcccgtc ttcctgggag     840

ggaccaaagg cggccaggat ataactgact tcaccatgca atttgtgtct tcctaaagag     900

agctgtaccc agagagtcct gtgctgaatg tggactcaat ccctagggct ggcagaaagg     960

gaacagaaag gtttttgagt acggctatag cctggacttt cctgttgtct acaccaatgc    1020

ccaactgcct gccttagggt agtgctaaga ggatctcctg tccatcagcc aggacagtca    1080

gctctctcct ttcagggcca atccccagcc cttttgttga gccaggcctc tctcacctct    1140

cctactcact taaagcccgc ctgacagaaa ccacggccac atttggttct aagaaaccct    1200

ctgtcattcg ctcccacatt ctgatgagca accgcttccc tatttattta tttatttgtt    1260

tgtttgtttt attcattggt ctaatttatt caaagggggc aagaagtagc agtgtctgta    1320

aaagagccta gtttttaata gctatggaat caattcaatt tggactggtg tgctctcttt    1380

aaatcaagtc ctttaattaa gactgaaaat atataagctc agattattta aatgggaata    1440

tttataaatg agcaaatatc atactgttca atggttctga aataaacttc tctgaag       1497


<210> 59
<211> 1707
<212> DNA
<213> Artificial Sequence


<220> 
<223> TUBA Plasmid

<400> 59
aagtgaacaa tgggcgccca gctctaaaat gacagcctgg ttcaatgggg tggaggagct      60

agggagggat gagtgctttg tgtgcttgga attagatcct tcaaatggat cctttctgaa     120

tgcaaaactg tacatctcta actggattct tatttacttc accaggactc ttcagctccc     180

tgcgcctttt aacacatgca catccagcaa aagcagagga gaacctggct gtgattcaaa     240

gcgtgagtgc atctccatcc acgttggcca ggctggtgtc cagattggca atgcctgctg     300

ggagctctac tgcctggaac acggcatcca gcccgatggc cagatgccaa gtgacaagac     360

cattggggga ggagatgatt ccttcaacac cttcttcagt gaaacgggtg ctggcaagca     420

tgtgccccgg gcagtgtttg tagacttgga acccacagtc attgatgaag ttcgcactgg     480

cacttaccgc cagctcttcc accctgagca actcatcaca ggcaaggaag atgctgccaa     540

taactatgcc cgagggcact acaccattgg caaggagatc attgacctcg tgttggaccg     600

aattcgcaag ctggctgacc agtgcaccgg tcttcagggc ttcttggttt tccacagctt     660

tggtggggga actggttctg ggttcacctc gctgctcatg gaacgtctct cagttgatta     720

tggcaagaag tccaagctgg agttctccat ttacccggcg ccccaggttt ccacagctgt     780

agttgagccc tacaactcca tcctcaccac ccacaccacc ctggagcact ctgattgtgc     840

cttcatggta gacaatgagg ccatctatga catctgtcgt agaaacctcg atatcgagcg     900

cccaacctac actaacctta accgccttat tagccagatt gtgtcctcca tcactgcttc     960

cctgagattt gatggagccc tgaatgttga cctgacagaa ttccagacca acctggtgcc    1020

ctacccccgc atccacttcc ctctggccac atatgcccct gtcatctctg ctgagaaagc    1080

ctaccacgaa cagcttactg tagcagagat caccaatgct tgctttgagc cagccaacca    1140

gatggtgaaa tgtgaccctc gccatggtaa atacatggct tgctgcctgt tataccgtgg    1200

tgacgtggtt cccaaagatg tcaatgctgc cattgccacc atcaaaacca agcgtaccat    1260

ccagtttgtg gattggtgcc ccactggctt caaggttggc attaattacc agcctcccac    1320

tgtggtgcct ggcggagacc tggccaaggt acagagagct gtgtgcatgc tgagcaatac    1380

cacagctgtt gccgaggcct gggctcgcct ggaccacaag tttgacctga tgtatgccaa    1440

gcgtgccttt gttcactggt acgtgggtga ggggatggag gaaggcgagt tttcagaggc    1500

ccgtgaggac atggctgccc ttgagaagga ttatgaggag gttggagcag atagtgctga    1560

cggagaggat gagggtgaag agtattaacc tgtgtgctgt acttttacac tcctttgtct    1620

tggaactgtc ttatttttgt tctgtaaatg tctattgccg taaattgtta ataaaattga    1680

agtttccatt ttaaatgtca aaaaaaa                                        1707


<210> 60
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> GAPDH Fwd

<400> 60
caactacatg gtctacatgt tc                                             22


<210> 61
<211> 17
<212> DNA
<213> Artificial Sequence


<220> 
<223> GAPDH Rev

<400> 61
ctcgctcctg gaagatg                                                   17


<210> 62
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> GAPDH Probe

<400> 62
cggcacagtc aaggccgaga a                                              21


<210> 63
<211> 15
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACTB Fwd

<400> 63
cttcaccacc acggc                                                     15


<210> 64
<211> 17
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACTB Rev

<400> 64
ccatctcttg ctcgaag                                                   17


<210> 65
<211> 26
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACTB Probe

<400> 65
tcgtgcgtga cattaaggag aagctg                                         26


<210> 66
<211> 17
<212> DNA
<213> Artificial Sequence


<220> 
<223> IL1-B Fwd

<400> 66
tgctccttcc aggacct                                                   17


<210> 67
<211> 17
<212> DNA
<213> Artificial Sequence


<220> 
<223> IL1-B Rev

<400> 67
gtggtggtcg gagattc                                                   17


<210> 68
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Il1-B Probe

<400> 68
ctctgccctc tggatggcgg c                                              21


<210> 69
<211> 16
<212> DNA
<213> Artificial Sequence


<220> 
<223> TUBA Fwd

<400> 69
tcgcaagctg gctgac                                                    16


<210> 70
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> TUBA Rev

<400> 70
aggtgaaccc agaaccagtt                                                20


<210> 71
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> TUBA Probe

<400> 71
caccggtctt cagggcttct tg                                             22


<210> 72
<211> 73
<212> PRT
<213> Artificial Sequence


<220> 
<223> 400-472 region of M501 and M503

<400> 72
Gln Ile Gly Lys Ser Ala Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro 
1               5                   10                  15      
Lys Gly Phe Ala Glu Tyr Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu 
            20                  25                  30          
Glu Met Ala Ile Glu Ile Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys 
        35                  40                  45              
Ile Ala Glu Gln Gln Lys Lys Ala Tyr Glu Arg Phe Lys Tyr Ala Glu 
    50                  55                  60                  
Phe Val Asp Asn Glu Thr Trp Leu Asn 
65                  70              

<210> 73
<211> 2628
<212> DNA
<213> Artificial Sequence


<220> 
<223> M601

<400> 73
atgcgtggta tgcttccact gtttgaaccg aaaggccgtg tgctgctggt tgatggccac      60

catctggcct atcgtacctt ccatgcgctg aaaggcctga cgaccagccg cggcgaaccg     120

gtgcaggcgg tgtatggctt tgcgaaaagc ctgctgaaag cgctgaaaga agatggcgat     180

gcggttattg tggtgtttga tgcgaaagcg ccgagctttc gtcatgaagc gtatggcggc     240

tataaagcgg gtcgtgcgcc gaccccggaa gattttccgc gtcagctggc cctgattaaa     300

gaactggtgg atctgctggg cctggcgcgt ctggaagtgc cgggctatga agcggatgat     360

gtgctggcca gcctggccaa aaaagcggaa aaagaaggct acgaagttcg tattctgacc     420

gccgataaag acctgtatca gctgctgtct gatcgtattc atgtgctgca tcctgagggt     480

tatctgatta ccccggcgtg gctgtgggaa aaatatggcc tgcgtccgga tcagtgggcg     540

gattatcgtg cgctgaccgg cgatgaaagc gataacctgc cgggcgtgaa aggcattggc     600

gaaaaaaccg cgcgtaaact gctggaagaa tggggcagcc tggaagcgct gctgaaaaac     660

ctggatcgtc tgaaaccggc gattcgtgaa aagatcttag cgcacatgga tgatctgaaa     720

ctgagctggg atctggccaa agtgcgtacc gatctgccgc tggaagtgga ttttgcgaaa     780

cgtcgtgaac cggatcgtga acgtctgcgt gcgtttctgg aacgtctgga atttggcagc     840

ctgctgcatg aatttggcct gctggaaagc ggtggcggcg gttctggcgg tggtggcagc     900

aataccccga aaccgattct gaaaccgcag agcaaagcac tggttgaacc tgttctgtgt     960

gatagcattg atgaaattcc ggcaaaatac aatgaacctg tgtattttga tctggaaacc    1020

gatgaagatc gtccggttct ggcaagcatt tatcagccgc attttgaacg taaagtgtat    1080

tgtctgaatc tgctgcgtga aaaactggca cgttttaaag aatggctgct gaaatttagc    1140

gaaattcgtg gttggggctt agatttcgat ctgcgtgttc tgggttatac ctatgaacag    1200

ctgcgcaaca aaaaaatcgt tgacgtccag ctggccatta aagtgcagca ttatgaacgc    1260

tttaaacaag gtggcaccaa aggtgaaggt tttcgtctgg atgatgttgc acgtgatctg    1320

ctgggtattg aatatccgat gaacaaaacg aaaatccgca ccaccttcaa gtataacatg    1380

tatagcagct tttcgtacga gcaactgctg tatgcaagcc tggatgcata tattccgcat    1440

ctgctgtacg aacgtctgag cagcgatacc ctgaatagcc tggtttatca gattgatcaa    1500

gaggttcaga aagtggtgat tgaaaccagc cagcatggta tgccggttaa actgaaagca    1560

ctggaagaag aaattcatcg tctgacccag ctgcgtagcg aaatgcagaa acaaattccg    1620

tttaactata atagcccgaa acagaccgcc aaattctttg gtgttaatag cagcagcaaa    1680

gatgttctga tggatctggc actgcgtggt aatgaagttg ccaaaaaagt tctggaagca    1740

cgccagattg aaaaaagtct ggcattcgcc aaagatctgt atgatatcgc caaaaaaaac    1800

ggtggtcgca tctatggtaa cttttttacc accaccgcac cgagcggtcg tatgagctgt    1860

agcaatatta acctgcagaa cattccgcgt cgtctgcgtc cgtttattgg ttttgaaacc    1920

gaggacaaaa aactgatcac cgcagatttt ccgcagattg aactgcgtct ggcaggcgtt    1980

atgtggaatg aacctgaatt tctgaaagcc tttcgtgatg gcattgatct gcacaaactg    2040

accgcaagta ttctgttcga taaaaagatt aacgaagtga gcaaagagga acgccagatc    2100

ggtaaaagcg caaattttgg tctgatttat ggtatcagcc cgaaaggttt tgccgaatat    2160

tgtattagca acggcattaa catcaccgaa gaaatggcaa tcgagatcgt gaaaaaatgg    2220

aagaagttct atcgcaaaat cgccgaacag catcagctgg catatgaacg tttcaaatat    2280

gccgaattcg tggataatga aacctggctg aatcgtccgt atcgtgcttg caaaccgcaa    2340

gccctgctta actatcagat tcaaggtagc ggtgcagaac tgttcaaaaa agcaattgtt    2400

ctgctgaaag aagccaaacc ggatctgaaa attgtgaatc tggttcacga tgaaattgtg    2460

gtggaaacca gtaccgaaga agcagaagat attgcactgc tggtgaaaca aaagatggaa    2520

gaggcatggg attattgcct ggaaaaagca aaagaatttg gcaataacgt ggccgacatt    2580

aaactggaag ttgaaaaacc gaatattagc agcgtgtggg aaaaagaa                 2628


<210> 74
<211> 876
<212> PRT
<213> Artificial Sequence


<220> 
<223> M601

<400> 74
Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      
Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          
Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              
Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  
Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  
Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      
Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         
Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             
Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 
Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 
Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     
Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         
Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             
Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 
Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 
Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     
Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         
Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             
Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Thr Pro Lys 
    290                 295                 300                 
Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val Glu Pro Val Leu Cys 
305                 310                 315                 320 
Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn Glu Pro Val Tyr Phe 
                325                 330                 335     
Asp Leu Glu Thr Asp Glu Asp Arg Pro Val Leu Ala Ser Ile Tyr Gln 
            340                 345                 350         
Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn Leu Leu Arg Glu Lys 
        355                 360                 365             
Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe Ser Glu Ile Arg Gly 
    370                 375                 380                 
Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly Tyr Thr Tyr Glu Gln 
385                 390                 395                 400 
Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu Ala Ile Lys Val Gln 
                405                 410                 415     
His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys Gly Glu Gly Phe Arg 
            420                 425                 430         
Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile Glu Tyr Pro Met Asn 
        435                 440                 445             
Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn Met Tyr Ser Ser Phe 
    450                 455                 460                 
Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp Ala Tyr Ile Pro His 
465                 470                 475                 480 
Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu Asn Ser Leu Val Tyr 
                485                 490                 495     
Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile Glu Thr Ser Gln His 
            500                 505                 510         
Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu Glu Ile His Arg Leu 
        515                 520                 525             
Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn 
    530                 535                 540                 
Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser Lys 
545                 550                 555                 560 
Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn Glu Val Ala Lys Lys 
                565                 570                 575     
Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu Ala Phe Ala Lys Asp 
            580                 585                 590         
Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg Ile Tyr Gly Asn Phe 
        595                 600                 605             
Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser Cys Ser Asn Ile Asn 
    610                 615                 620                 
Leu Gln Asn Ile Pro Arg Arg Leu Arg Pro Phe Ile Gly Phe Glu Thr 
625                 630                 635                 640 
Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro Gln Ile Glu Leu Arg 
                645                 650                 655     
Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe Leu Lys Ala Phe Arg 
            660                 665                 670         
Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser Ile Leu Phe Asp Lys 
        675                 680                 685             
Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln Ile Gly Lys Ser Ala 
    690                 695                 700                 
Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys Gly Phe Ala Glu Tyr 
705                 710                 715                 720 
Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu Met Ala Ile Glu Ile 
                725                 730                 735     
Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile Ala Glu Gln His Gln 
            740                 745                 750         
Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe Val Asp Asn Glu Thr 
        755                 760                 765             
Trp Leu Asn Arg Pro Tyr Arg Ala Cys Lys Pro Gln Ala Leu Leu Asn 
    770                 775                 780                 
Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe Lys Lys Ala Ile Val 
785                 790                 795                 800 
Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile Val Asn Leu Val His 
                805                 810                 815     
Asp Glu Ile Val Val Glu Thr Ser Thr Glu Glu Ala Glu Asp Ile Ala 
            820                 825                 830         
Leu Leu Val Lys Gln Lys Met Glu Glu Ala Trp Asp Tyr Cys Leu Glu 
        835                 840                 845             
Lys Ala Lys Glu Phe Gly Asn Asn Val Ala Asp Ile Lys Leu Glu Val 
    850                 855                 860                 
Glu Lys Pro Asn Ile Ser Ser Val Trp Glu Lys Glu 
865                 870                 875     

<210> 75
<211> 2628
<212> DNA
<213> Artificial Sequence


<220> 
<223> M602

<400> 75
atgcgtggta tgcttccact gtttgaaccg aaaggccgtg tgctgctggt tgatggccac      60

catctggcct atcgtacctt ccatgcgctg aaaggcctga cgaccagccg cggcgaaccg     120

gtgcaggcgg tgtatgactt tgcgaaaagc ctgctgaaag cgctgaaaga agatggcgat     180

gcggttattg tggtgtttga tgcgaaagcg ccgagctttc gtcatgaagc gtatggcggc     240

tataaagcgg gtcgtgcgcc gaccccggaa gattttccgc gtcagctggc cctgattaaa     300

gaactggtgg atctgctggg cctggcgcgt ctggaagtgc cgggctatga agcggatgat     360

gtgctggcca gcctggccaa aaaagcggaa aaagaaggct acgaagttcg tattctgacc     420

gccgataaag acctgtatca gctgctgtct gatcgtattc atgtgctgca tcctgagggt     480

tatctgatta ccccggcgtg gctgtgggaa aaatatggcc tgcgtccgga tcagtgggcg     540

gattatcgtg cgctgaccgg cgatgaaagc gataacctgc cgggcgtgaa aggcattggc     600

gaaaaaaccg cgcgtaaact gctggaagaa tggggcagcc tggaagcgct gctgaaaaac     660

ctggatcgtc tgaaaccggc gattcgtgaa aagatcttag cgcacatgga tgatctgaaa     720

ctgagctggg atctggccaa agtgcgtacc gatctgccgc tggaagtgga ttttgcgaaa     780

cgtcgtgaac cggatcgtga acgtctgcgt gcgtttctgg aacgtctgga atttggcagc     840

ctgctgcatg aatttggcct gctggaaagc ggtggcggcg gttctggcgg tggtggcagc     900

aataccccga aaccgattct gaaaccgcag agcaaagcac tggttgaacc tgttctgtgt     960

gatagcattg atgaaattcc ggcaaaatac aatgaacctg tgtattttga tctggaaacc    1020

gatgaagatc gtccggttct ggcaagcatt tatcagccgc attttgaacg taaagtgtat    1080

tgtctgaatc tgctgcgtga aaaactggca cgttttaaag aatggctgct gaaatttagc    1140

gaaattcgtg gttggggctt agatttcgat ctgcgtgttc tgggttatac ctatgaacag    1200

ctgcgcaaca aaaaaatcgt tgacgtccag ctggccatta aagtgcagca ttatgaacgc    1260

tttaaacaag gtggcaccaa aggtgaaggt tttcgtctgg atgatgttgc acgtgatctg    1320

ctgggtattg aatatccgat gaacaaaacg aaaatccgca ccaccttcaa gtataacatg    1380

tatagcagct tttcgtacga gcaactgctg tatgcaagcc tggatgcata tattccgcat    1440

ctgctgtacg aacgtctgag cagcgatacc ctgaatagcc tggtttatca gattgatcaa    1500

gaggttcaga aagtggtgat tgaaaccagc cagcatggta tgccggttaa actgaaagca    1560

ctggaagaag aaattcatcg tctgacccag ctgcgtagcg aaatgcagaa acaaattccg    1620

tttaactata atagcccgaa acagaccgcc aaattctttg gtgttaatag cagcagcaaa    1680

gatgttctga tggatctggc actgcgtggt aatgaagttg ccaaaaaagt tctggaagca    1740

cgccagattg aaaaaagtct ggcattcgcc aaagatctgt atgatatcgc caaaaaaaac    1800

ggtggtcgca tctatggtaa cttttttacc accaccgcac cgagcggtcg tatgagctgt    1860

agcaatatta acctgcagaa cattccgcgt cgtctgcgtc cgtttattgg ttttgaaacc    1920

gaggacaaaa aactgatcac cgcagatttt ccgcagattg aactgcgtct ggcaggcgtt    1980

atgtggaatg aacctgaatt tctgaaagcc tttcgtgatg gcattgatct gcacaaactg    2040

accgcaagta ttctgttcga taaaaagatt aacgaagtga gcaaagagga acgccagatc    2100

ggtaaaagcg caaattttgg tctgatttat ggtatcagcc cgaaaggttt tgccgaatat    2160

tgtattagca acggcattaa catcaccgaa gaaatggcaa tcgagatcgt gaaaaaatgg    2220

aagaagttct atcgcaaaat cgccgaacag catcagctgg catatgaacg tttcaaatat    2280

gccgaattcg tggataatga aacctggctg aatcgtccgt atcgtgcttg caaaccgcaa    2340

gccctgctta actatcagat tcaaggtagc ggtgcagaac tgttcaaaaa agcaattgtt    2400

ctgctgaaag aagccaaacc ggatctgaaa attgtgaatc tggttcacga tgaaattgtg    2460

gtggaaacca gtaccgaaga agcagaagat attgcactgc tggtgaaaca aaagatggaa    2520

gaggcatggg attattgcct ggaaaaagca aaagaatttg gcaataacgt ggccgacatt    2580

aaactggaag ttgaaaaacc gaatattagc agcgtgtggg aaaaagaa                 2628


<210> 76
<211> 876
<212> PRT
<213> Artificial Sequence


<220> 
<223> M602

<400> 76
Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      
Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          
Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Asp Phe Ala 
        35                  40                  45              
Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  
Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  
Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      
Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         
Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             
Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 
Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 
Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     
Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         
Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             
Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 
Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 
Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     
Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         
Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             
Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Thr Pro Lys 
    290                 295                 300                 
Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val Glu Pro Val Leu Cys 
305                 310                 315                 320 
Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn Glu Pro Val Tyr Phe 
                325                 330                 335     
Asp Leu Glu Thr Asp Glu Asp Arg Pro Val Leu Ala Ser Ile Tyr Gln 
            340                 345                 350         
Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn Leu Leu Arg Glu Lys 
        355                 360                 365             
Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe Ser Glu Ile Arg Gly 
    370                 375                 380                 
Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly Tyr Thr Tyr Glu Gln 
385                 390                 395                 400 
Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu Ala Ile Lys Val Gln 
                405                 410                 415     
His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys Gly Glu Gly Phe Arg 
            420                 425                 430         
Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile Glu Tyr Pro Met Asn 
        435                 440                 445             
Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn Met Tyr Ser Ser Phe 
    450                 455                 460                 
Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp Ala Tyr Ile Pro His 
465                 470                 475                 480 
Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu Asn Ser Leu Val Tyr 
                485                 490                 495     
Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile Glu Thr Ser Gln His 
            500                 505                 510         
Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu Glu Ile His Arg Leu 
        515                 520                 525             
Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn 
    530                 535                 540                 
Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser Lys 
545                 550                 555                 560 
Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn Glu Val Ala Lys Lys 
                565                 570                 575     
Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu Ala Phe Ala Lys Asp 
            580                 585                 590         
Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg Ile Tyr Gly Asn Phe 
        595                 600                 605             
Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser Cys Ser Asn Ile Asn 
    610                 615                 620                 
Leu Gln Asn Ile Pro Arg Arg Leu Arg Pro Phe Ile Gly Phe Glu Thr 
625                 630                 635                 640 
Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro Gln Ile Glu Leu Arg 
                645                 650                 655     
Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe Leu Lys Ala Phe Arg 
            660                 665                 670         
Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser Ile Leu Phe Asp Lys 
        675                 680                 685             
Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln Ile Gly Lys Ser Ala 
    690                 695                 700                 
Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys Gly Phe Ala Glu Tyr 
705                 710                 715                 720 
Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu Met Ala Ile Glu Ile 
                725                 730                 735     
Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile Ala Glu Gln His Gln 
            740                 745                 750         
Leu Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe Val Asp Asn Glu Thr 
        755                 760                 765             
Trp Leu Asn Arg Pro Tyr Arg Ala Cys Lys Pro Gln Ala Leu Leu Asn 
    770                 775                 780                 
Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe Lys Lys Ala Ile Val 
785                 790                 795                 800 
Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile Val Asn Leu Val His 
                805                 810                 815     
Asp Glu Ile Val Val Glu Thr Ser Thr Glu Glu Ala Glu Asp Ile Ala 
            820                 825                 830         
Leu Leu Val Lys Gln Lys Met Glu Glu Ala Trp Asp Tyr Cys Leu Glu 
        835                 840                 845             
Lys Ala Lys Glu Phe Gly Asn Asn Val Ala Asp Ile Lys Leu Glu Val 
    850                 855                 860                 
Glu Lys Pro Asn Ile Ser Ser Val Trp Glu Lys Glu 
865                 870                 875     

<210> 77
<211> 2628
<212> DNA
<213> Artificial Sequence


<220> 
<223> M603

<400> 77
atgcgtggta tgcttccact gtttgaaccg aaaggccgtg tgctgctggt tgatggccac      60

catctggcct atcgtacctt ccatgcgctg aaaggcctga cgaccagccg cggcgaaccg     120

gtgcaggcgg tgtatggctt tgcgaaaagc ctgctgaaag cgctgaaaga agatggcgat     180

gcggttattg tggtgtttga tgcgaaagcg ccgagctttc gtcatgaagc gtatggcggc     240

tataaagcgg gtcgtgcgcc gaccccggaa gattttccgc gtcagctggc cctgattaaa     300

gaactggtgg atctgctggg cctggcgcgt ctggaagtgc cgggctatga agcggatgat     360

gtgctggcca gcctggccaa aaaagcggaa aaagaaggct acgaagttcg tattctgacc     420

gccgataaag acctgtatca gctgctgtct gatcgtattc atgtgctgca tcctgagggt     480

tatctgatta ccccggcgtg gctgtgggaa aaatatggcc tgcgtccgga tcagtgggcg     540

gattatcgtg cgctgaccgg cgatgaaagc gataacctgc cgggcgtgaa aggcattggc     600

gaaaaaaccg cgcgtaaact gctggaagaa tggggcagcc tggaagcgct gctgaaaaac     660

ctggatcgtc tgaaaccggc gattcgtgaa aagatcttag cgcacatgga tgatctgaaa     720

ctgagctggg atctggccaa agtgcgtacc gatctgccgc tggaagtgga ttttgcgaaa     780

cgtcgtgaac cggatcgtga acgtctgcgt gcgtttctgg aacgtctgga atttggcagc     840

ctgctgcatg aatttggcct gctggaaagc ggtggcggcg gttctggcgg tggtggcagc     900

aataccccga aaccgattct gaaaccgcag agcaaagcac tggttgaacc tgttctgtgt     960

gatagcattg atgaaattcc ggcaaaatac aatgaacctg tgtattttga tctggaaacc    1020

gatgaagatc gtccggttct ggcaagcatt tatcagccgc attttgaacg taaagtgtat    1080

tgtctgaatc tgctgcgtga aaaactggca cgttttaaag aatggctgct gaaatttagc    1140

gaaattcgtg gttggggctt agatttcgat ctgcgtgttc tgggttatac ctatgaacag    1200

ctgcgcaaca aaaaaatcgt tgacgtccag ctggccatta aagtgcagca ttatgaacgc    1260

tttaaacaag gtggcaccaa aggtgaaggt tttcgtctgg atgatgttgc acgtgatctg    1320

ctgggtattg aatatccgat gaacaaaacg aaaatccgca ccaccttcaa gtataacatg    1380

tatagcagct tttcgtacga gcaactgctg tatgcaagcc tggatgcata tattccgcat    1440

ctgctgtacg aacgtctgag cagcgatacc ctgaatagcc tggtttatca gattgatcaa    1500

gaggttcaga aagtggtgat tgaaaccagc cagcatggta tgccggttaa actgaaagca    1560

ctggaagaag aaattcatcg tctgacccag ctgcgtagcg aaatgcagaa acaaattccg    1620

tttaactata atagcccgaa acagaccgcc aaattctttg gtgttaatag cagcagcaaa    1680

gatgttctga tggatctggc actgcgtggt aatgaagttg ccaaaaaagt tctggaagca    1740

cgccagattg aaaaaagtct ggcattcgcc aaagatctgt atgatatcgc caaaaaaaac    1800

ggtggtcgca tctatggtaa cttttttacc accaccgcac cgagcggtcg tatgagctgt    1860

agcgatatta acctgcagaa cattccgcgt cgtctgcgtc cgtttattgg ttttgaaacc    1920

gaggacaaaa aactgatcac cgcagatttt ccgcagattg aactgcgtct ggcaggcgtt    1980

atgtggaatg aacctgaatt tctgaaagcc tttcgtgatg gcattgatct gcacaaactg    2040

accgcaagta ttctgttcga taaaaagatt aacgaagtga gcaaagagga acgccagatc    2100

ggtaaaagcg caaattttgg tctgatttat ggtatcagcc cgaaaggttt tgccgaatat    2160

tgtattagca acggcattaa catcaccgaa gaaatggcaa tcgagatcgt gaaaaaatgg    2220

aagaagttct atcgcaaaat cgccgaacag cagaagaagg catatgaacg tttcaaatat    2280

gccgaattcg tggataatga aacctggctg aatcgtccgt atcgtgcatg gaaaccgcaa    2340

gatctgctga actatcagat tcaaggtagc ggtgcagaac tgttcaaaaa agcaattgtt    2400

ctgctgaaag aagccaaacc ggatctgaaa attgtgaatc tggttcacga tgaaattgtg    2460

gtggaaacca gtaccgaaga agcagaagat attgcactgc tggtgaaaca aaagatggaa    2520

gaggcatggg attattgcct ggaaaaagca aaagaatttg gcaataacgt ggccgacatt    2580

aaactggaag ttgaaaaacc gaatattagc agcgtgtggg aaaaagaa                 2628


<210> 78
<211> 876
<212> PRT
<213> Artificial Sequence


<220> 
<223> M603

<400> 78
Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      
Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          
Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              
Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  
Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  
Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      
Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         
Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             
Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 
Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 
Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     
Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         
Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             
Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 
Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 
Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     
Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         
Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             
Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Thr Pro Lys 
    290                 295                 300                 
Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val Glu Pro Val Leu Cys 
305                 310                 315                 320 
Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn Glu Pro Val Tyr Phe 
                325                 330                 335     
Asp Leu Glu Thr Asp Glu Asp Arg Pro Val Leu Ala Ser Ile Tyr Gln 
            340                 345                 350         
Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn Leu Leu Arg Glu Lys 
        355                 360                 365             
Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe Ser Glu Ile Arg Gly 
    370                 375                 380                 
Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly Tyr Thr Tyr Glu Gln 
385                 390                 395                 400 
Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu Ala Ile Lys Val Gln 
                405                 410                 415     
His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys Gly Glu Gly Phe Arg 
            420                 425                 430         
Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile Glu Tyr Pro Met Asn 
        435                 440                 445             
Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn Met Tyr Ser Ser Phe 
    450                 455                 460                 
Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp Ala Tyr Ile Pro His 
465                 470                 475                 480 
Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu Asn Ser Leu Val Tyr 
                485                 490                 495     
Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile Glu Thr Ser Gln His 
            500                 505                 510         
Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu Glu Ile His Arg Leu 
        515                 520                 525             
Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn 
    530                 535                 540                 
Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser Lys 
545                 550                 555                 560 
Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn Glu Val Ala Lys Lys 
                565                 570                 575     
Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu Ala Phe Ala Lys Asp 
            580                 585                 590         
Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg Ile Tyr Gly Asn Phe 
        595                 600                 605             
Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser Cys Ser Asp Ile Asn 
    610                 615                 620                 
Leu Gln Asn Ile Pro Arg Arg Leu Arg Pro Phe Ile Gly Phe Glu Thr 
625                 630                 635                 640 
Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro Gln Ile Glu Leu Arg 
                645                 650                 655     
Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe Leu Lys Ala Phe Arg 
            660                 665                 670         
Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser Ile Leu Phe Asp Lys 
        675                 680                 685             
Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln Ile Gly Lys Ser Ala 
    690                 695                 700                 
Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys Gly Phe Ala Glu Tyr 
705                 710                 715                 720 
Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu Met Ala Ile Glu Ile 
                725                 730                 735     
Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile Ala Glu Gln Gln Lys 
            740                 745                 750         
Lys Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe Val Asp Asn Glu Thr 
        755                 760                 765             
Trp Leu Asn Arg Pro Tyr Arg Ala Trp Lys Pro Gln Asp Leu Leu Asn 
    770                 775                 780                 
Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe Lys Lys Ala Ile Val 
785                 790                 795                 800 
Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile Val Asn Leu Val His 
                805                 810                 815     
Asp Glu Ile Val Val Glu Thr Ser Thr Glu Glu Ala Glu Asp Ile Ala 
            820                 825                 830         
Leu Leu Val Lys Gln Lys Met Glu Glu Ala Trp Asp Tyr Cys Leu Glu 
        835                 840                 845             
Lys Ala Lys Glu Phe Gly Asn Asn Val Ala Asp Ile Lys Leu Glu Val 
    850                 855                 860                 
Glu Lys Pro Asn Ile Ser Ser Val Trp Glu Lys Glu 
865                 870                 875     

<210> 79
<211> 2628
<212> DNA
<213> Artificial Sequence


<220> 
<223> M604

<400> 79
atgcgtggta tgcttccact gtttgaaccg aaaggccgtg tgctgctggt tgatggccac      60

catctggcct atcgtacctt ccatgcgctg aaaggcctga cgaccagccg cggcgaaccg     120

gtgcaggcgg tgtatgactt tgcgaaaagc ctgctgaaag cgctgaaaga agatggcgat     180

gcggttattg tggtgtttga tgcgaaagcg ccgagctttc gtcatgaagc gtatggcggc     240

tataaagcgg gtcgtgcgcc gaccccggaa gattttccgc gtcagctggc cctgattaaa     300

gaactggtgg atctgctggg cctggcgcgt ctggaagtgc cgggctatga agcggatgat     360

gtgctggcca gcctggccaa aaaagcggaa aaagaaggct acgaagttcg tattctgacc     420

gccgataaag acctgtatca gctgctgtct gatcgtattc atgtgctgca tcctgagggt     480

tatctgatta ccccggcgtg gctgtgggaa aaatatggcc tgcgtccgga tcagtgggcg     540

gattatcgtg cgctgaccgg cgatgaaagc gataacctgc cgggcgtgaa aggcattggc     600

gaaaaaaccg cgcgtaaact gctggaagaa tggggcagcc tggaagcgct gctgaaaaac     660

ctggatcgtc tgaaaccggc gattcgtgaa aagatcttag cgcacatgga tgatctgaaa     720

ctgagctggg atctggccaa agtgcgtacc gatctgccgc tggaagtgga ttttgcgaaa     780

cgtcgtgaac cggatcgtga acgtctgcgt gcgtttctgg aacgtctgga atttggcagc     840

ctgctgcatg aatttggcct gctggaaagc ggtggcggcg gttctggcgg tggtggcagc     900

aataccccga aaccgattct gaaaccgcag agcaaagcac tggttgaacc tgttctgtgt     960

gatagcattg atgaaattcc ggcaaaatac aatgaacctg tgtattttga tctggaaacc    1020

gatgaagatc gtccggttct ggcaagcatt tatcagccgc attttgaacg taaagtgtat    1080

tgtctgaatc tgctgcgtga aaaactggca cgttttaaag aatggctgct gaaatttagc    1140

gaaattcgtg gttggggctt agatttcgat ctgcgtgttc tgggttatac ctatgaacag    1200

ctgcgcaaca aaaaaatcgt tgacgtccag ctggccatta aagtgcagca ttatgaacgc    1260

tttaaacaag gtggcaccaa aggtgaaggt tttcgtctgg atgatgttgc acgtgatctg    1320

ctgggtattg aatatccgat gaacaaaacg aaaatccgca ccaccttcaa gtataacatg    1380

tatagcagct tttcgtacga gcaactgctg tatgcaagcc tggatgcata tattccgcat    1440

ctgctgtacg aacgtctgag cagcgatacc ctgaatagcc tggtttatca gattgatcaa    1500

gaggttcaga aagtggtgat tgaaaccagc cagcatggta tgccggttaa actgaaagca    1560

ctggaagaag aaattcatcg tctgacccag ctgcgtagcg aaatgcagaa acaaattccg    1620

tttaactata atagcccgaa acagaccgcc aaattctttg gtgttaatag cagcagcaaa    1680

gatgttctga tggatctggc actgcgtggt aatgaagttg ccaaaaaagt tctggaagca    1740

cgccagattg aaaaaagtct ggcattcgcc aaagatctgt atgatatcgc caaaaaaaac    1800

ggtggtcgca tctatggtaa cttttttacc accaccgcac cgagcggtcg tatgagctgt    1860

agcgatatta acctgcagaa cattccgcgt cgtctgcgtc cgtttattgg ttttgaaacc    1920

gaggacaaaa aactgatcac cgcagatttt ccgcagattg aactgcgtct ggcaggcgtt    1980

atgtggaatg aacctgaatt tctgaaagcc tttcgtgatg gcattgatct gcacaaactg    2040

accgcaagta ttctgttcga taaaaagatt aacgaagtga gcaaagagga acgccagatc    2100

ggtaaaagcg caaattttgg tctgatttat ggtatcagcc cgaaaggttt tgccgaatat    2160

tgtattagca acggcattaa catcaccgaa gaaatggcaa tcgagatcgt gaaaaaatgg    2220

aagaagttct atcgcaaaat cgccgaacag cagaagaagg catatgaacg tttcaaatat    2280

gccgaattcg tggataatga aacctggctg aatcgtccgt atcgtgcatg gaaaccgcaa    2340

gatctgctga actatcagat tcaaggtagc ggtgcagaac tgttcaaaaa agcaattgtt    2400

ctgctgaaag aagccaaacc ggatctgaaa attgtgaatc tggttcacga tgaaattgtg    2460

gtggaaacca gtaccgaaga agcagaagat attgcactgc tggtgaaaca aaagatggaa    2520

gaggcatggg attattgcct ggaaaaagca aaagaatttg gcaataacgt ggccgacatt    2580

aaactggaag ttgaaaaacc gaatattagc agcgtgtggg aaaaagaa                 2628


<210> 80
<211> 876
<212> PRT
<213> Artificial Sequence


<220> 
<223> M604

<400> 80
Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      
Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          
Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Asp Phe Ala 
        35                  40                  45              
Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  
Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  
Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      
Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         
Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             
Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 
Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 
Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     
Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         
Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             
Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 
Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 
Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     
Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         
Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             
Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Thr Pro Lys 
    290                 295                 300                 
Pro Ile Leu Lys Pro Gln Ser Lys Ala Leu Val Glu Pro Val Leu Cys 
305                 310                 315                 320 
Asp Ser Ile Asp Glu Ile Pro Ala Lys Tyr Asn Glu Pro Val Tyr Phe 
                325                 330                 335     
Asp Leu Glu Thr Asp Glu Asp Arg Pro Val Leu Ala Ser Ile Tyr Gln 
            340                 345                 350         
Pro His Phe Glu Arg Lys Val Tyr Cys Leu Asn Leu Leu Arg Glu Lys 
        355                 360                 365             
Leu Ala Arg Phe Lys Glu Trp Leu Leu Lys Phe Ser Glu Ile Arg Gly 
    370                 375                 380                 
Trp Gly Leu Asp Phe Asp Leu Arg Val Leu Gly Tyr Thr Tyr Glu Gln 
385                 390                 395                 400 
Leu Arg Asn Lys Lys Ile Val Asp Val Gln Leu Ala Ile Lys Val Gln 
                405                 410                 415     
His Tyr Glu Arg Phe Lys Gln Gly Gly Thr Lys Gly Glu Gly Phe Arg 
            420                 425                 430         
Leu Asp Asp Val Ala Arg Asp Leu Leu Gly Ile Glu Tyr Pro Met Asn 
        435                 440                 445             
Lys Thr Lys Ile Arg Thr Thr Phe Lys Tyr Asn Met Tyr Ser Ser Phe 
    450                 455                 460                 
Ser Tyr Glu Gln Leu Leu Tyr Ala Ser Leu Asp Ala Tyr Ile Pro His 
465                 470                 475                 480 
Leu Leu Tyr Glu Arg Leu Ser Ser Asp Thr Leu Asn Ser Leu Val Tyr 
                485                 490                 495     
Gln Ile Asp Gln Glu Val Gln Lys Val Val Ile Glu Thr Ser Gln His 
            500                 505                 510         
Gly Met Pro Val Lys Leu Lys Ala Leu Glu Glu Glu Ile His Arg Leu 
        515                 520                 525             
Thr Gln Leu Arg Ser Glu Met Gln Lys Gln Ile Pro Phe Asn Tyr Asn 
    530                 535                 540                 
Ser Pro Lys Gln Thr Ala Lys Phe Phe Gly Val Asn Ser Ser Ser Lys 
545                 550                 555                 560 
Asp Val Leu Met Asp Leu Ala Leu Arg Gly Asn Glu Val Ala Lys Lys 
                565                 570                 575     
Val Leu Glu Ala Arg Gln Ile Glu Lys Ser Leu Ala Phe Ala Lys Asp 
            580                 585                 590         
Leu Tyr Asp Ile Ala Lys Lys Asn Gly Gly Arg Ile Tyr Gly Asn Phe 
        595                 600                 605             
Phe Thr Thr Thr Ala Pro Ser Gly Arg Met Ser Cys Ser Asp Ile Asn 
    610                 615                 620                 
Leu Gln Asn Ile Pro Arg Arg Leu Arg Pro Phe Ile Gly Phe Glu Thr 
625                 630                 635                 640 
Glu Asp Lys Lys Leu Ile Thr Ala Asp Phe Pro Gln Ile Glu Leu Arg 
                645                 650                 655     
Leu Ala Gly Val Met Trp Asn Glu Pro Glu Phe Leu Lys Ala Phe Arg 
            660                 665                 670         
Asp Gly Ile Asp Leu His Lys Leu Thr Ala Ser Ile Leu Phe Asp Lys 
        675                 680                 685             
Lys Ile Asn Glu Val Ser Lys Glu Glu Arg Gln Ile Gly Lys Ser Ala 
    690                 695                 700                 
Asn Phe Gly Leu Ile Tyr Gly Ile Ser Pro Lys Gly Phe Ala Glu Tyr 
705                 710                 715                 720 
Cys Ile Ser Asn Gly Ile Asn Ile Thr Glu Glu Met Ala Ile Glu Ile 
                725                 730                 735     
Val Lys Lys Trp Lys Lys Phe Tyr Arg Lys Ile Ala Glu Gln Gln Lys 
            740                 745                 750         
Lys Ala Tyr Glu Arg Phe Lys Tyr Ala Glu Phe Val Asp Asn Glu Thr 
        755                 760                 765             
Trp Leu Asn Arg Pro Tyr Arg Ala Trp Lys Pro Gln Asp Leu Leu Asn 
    770                 775                 780                 
Tyr Gln Ile Gln Gly Ser Gly Ala Glu Leu Phe Lys Lys Ala Ile Val 
785                 790                 795                 800 
Leu Leu Lys Glu Ala Lys Pro Asp Leu Lys Ile Val Asn Leu Val His 
                805                 810                 815     
Asp Glu Ile Val Val Glu Thr Ser Thr Glu Glu Ala Glu Asp Ile Ala 
            820                 825                 830         
Leu Leu Val Lys Gln Lys Met Glu Glu Ala Trp Asp Tyr Cys Leu Glu 
        835                 840                 845             
Lys Ala Lys Glu Phe Gly Asn Asn Val Ala Asp Ile Lys Leu Glu Val 
    850                 855                 860                 
Glu Lys Pro Asn Ile Ser Ser Val Trp Glu Lys Glu 
865                 870                 875     

<210> 81
<211> 112
<212> RNA
<213> Artificial Sequence


<220> 
<223> template RNA

<400> 81
rurargrgrc rgrurcrgrg rurgrarcra rararcrgrg rcrcrargrc rgrururgru     60

rurgrurcru rcrurcrurg rururcrura rgrcrurura rurcrgrgru rc            112


<210> 82
<211> 74
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA primer strand containing a 3'-terminal nucleotide match

<400> 82
gccgatatcg gacaacggcc gaactgggaa ggcgagactg accgaccgat aagctagaac     60

agagagacaa caac                                                       74


<210> 83
<211> 75
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA primer strand containing a 3'-terminal dC mismatch

<400> 83
gccgatatcg gacaacggcc gaactgggaa ggcgagactg accgaccgat aagctagaac     60

agagagacaa caacc                                                      75


<210> 84
<211> 75
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA primer strand containing a 3'-terminal dA mismatch

<400> 84
gccgatatcg gacaacggcc gaactgggaa ggcgagactg accgaccgat aagctagaac     60

agagagacaa caaca                                                      75


<210> 85
<211> 75
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA primer strand containing a 3'-terminal dT mismatch

<400> 85
gccgatatcg gacaacggcc gaactgggaa ggcgagactg accgaccgat aagctagaac     60

agagagacaa caact                                                      75


<210> 86
<211> 25
<212> DNA
<213> Artificial Sequence


<220> 
<223> forward primer

<400> 86
ggacaacggc cgaactggga aggcg                                          25


<210> 87
<211> 25
<212> DNA
<213> Artificial Sequence


<220> 
<223> reverse primer

<400> 87
taggcgtcgg tgacaaacgg ccagc                                          25


<210> 88
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> probe

<220> 
<221> misc_structure
<222> 5'
<223> /note="5' FAM, ZEN quencher between base 9 and 10, 3'-Iowa Black"

<400> 88
actgaccgac cgataagcta gaacagagag                                     30


