                         SEQUENCE LISTING

<110>  Tropic Biosciences UK Limited
       MAORI, Eyal
       PIGNOCCHI, Cristina
       SIWOSZEK, Agnieszka
       GALANTY, Yaron
       KNEVITT, Daniel
       CHAPARRO GARCIA, Angela
       MEIR, Ofir
 
<120>  COMPOSITIONS AND METHODS FOR REDUCING CAFFEINE CONTENT IN COFFEE 
       BEANS

<130>  73882

<150>  1807192.8
<151>  2018-05-01

<160>  86    

<170>  PatentIn version 3.5

<210>  1
<211>  1137
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MXMT - Monomethylxanthine methyltransferase 1 nucleic acid 
       sequence

<400>  1
atggagctcc aagaagtcct gcatatgaat gaaggtgaag gcgatacaag ctacgccaag       60

aatgcatcct acaatctggc tcttgccaag gtgaaacctt tccttgaaca atgcatacga      120

gaattgttgc gggccaactt gcccaacatc aacaagtgca ttaaagttgc ggatttggga      180

tgcgcttctg gaccaaacac acttttaaca gtgcgggaca ttgtgcaaag tattgacaaa      240

gttggccagg aagagaagaa tgaattagaa cgtcccacca ttcagatttt tctgaatgat      300

cttttccaaa atgatttcaa ttcggttttc aagttgctgc caagcttcta ccgcaaactc      360

gagaaagaaa atggacgcaa gataggatcg tgcctaataa gcgcaatgcc tggctctttc      420

tacggcagac tcttccccga ggagtccatg cattttttgc actcttgtta cagtgttcat      480

tggttatctc aggttcccag cggtttggtg attgaattgg ggattggtgc aaacaaaggg      540

agtatttact cttccaaagg atgtcgtccg cccgtccaga aggcatattt ggatcaattt      600

acgaaagatt ttaccacatt tctaaggatt cattcgaaag agttgttttc acgtggccga      660

atgctcctta cttgcatttg taaagtagat gaattcgacg aaccgaatcc cctagactta      720

cttgacatgg caataaacga cttgattgtt gagggacttc tggaggaaga aaaattggat      780

agtttcaata ttccattctt tacaccttca gcagaagaag taaagtgcat agttgaggag      840

gaaggttctt gcgaaatttt atatctggag acttttaagg cccattatga tgctgccttc      900

tctattgatg atgattaccc agtaacatcc catgaacaaa ttaaagcaga gtatgtggca      960

tcattaatta gatcagttta cgaacccatc ctcgcaagtc attttggaga agctattatg     1020

cctgacttat tccacaggct tgcgaagcat gcagcaaagg ttctccacat gggcaaaggc     1080

tgctataata atcttatcat ttctctcgcc aaaaagccag agaagtcaga cgtgtaa        1137


<210>  2
<211>  378
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MXMT - Monomethylxanthine methyltransferase 1  amino acid 
       sequence

<400>  2

Met Glu Leu Gln Glu Val Leu His Met Asn Glu Gly Glu Gly Asp Thr 
1               5                   10                  15      


Ser Tyr Ala Lys Asn Ala Ser Tyr Asn Leu Ala Leu Ala Lys Val Lys 
            20                  25                  30          


Pro Phe Leu Glu Gln Cys Ile Arg Glu Leu Leu Arg Ala Asn Leu Pro 
        35                  40                  45              


Asn Ile Asn Lys Cys Ile Lys Val Ala Asp Leu Gly Cys Ala Ser Gly 
    50                  55                  60                  


Pro Asn Thr Leu Leu Thr Val Arg Asp Ile Val Gln Ser Ile Asp Lys 
65                  70                  75                  80  


Val Gly Gln Glu Glu Lys Asn Glu Leu Glu Arg Pro Thr Ile Gln Ile 
                85                  90                  95      


Phe Leu Asn Asp Leu Phe Gln Asn Asp Phe Asn Ser Val Phe Lys Leu 
            100                 105                 110         


Leu Pro Ser Phe Tyr Arg Lys Leu Glu Lys Glu Asn Gly Arg Lys Ile 
        115                 120                 125             


Gly Ser Cys Leu Ile Ser Ala Met Pro Gly Ser Phe Tyr Gly Arg Leu 
    130                 135                 140                 


Phe Pro Glu Glu Ser Met His Phe Leu His Ser Cys Tyr Ser Val His 
145                 150                 155                 160 


Trp Leu Ser Gln Val Pro Ser Gly Leu Val Ile Glu Leu Gly Ile Gly 
                165                 170                 175     


Ala Asn Lys Gly Ser Ile Tyr Ser Ser Lys Gly Cys Arg Pro Pro Val 
            180                 185                 190         


Gln Lys Ala Tyr Leu Asp Gln Phe Thr Lys Asp Phe Thr Thr Phe Leu 
        195                 200                 205             


Arg Ile His Ser Lys Glu Leu Phe Ser Arg Gly Arg Met Leu Leu Thr 
    210                 215                 220                 


Cys Ile Cys Lys Val Asp Glu Phe Asp Glu Pro Asn Pro Leu Asp Leu 
225                 230                 235                 240 


Leu Asp Met Ala Ile Asn Asp Leu Ile Val Glu Gly Leu Leu Glu Glu 
                245                 250                 255     


Glu Lys Leu Asp Ser Phe Asn Ile Pro Phe Phe Thr Pro Ser Ala Glu 
            260                 265                 270         


Glu Val Lys Cys Ile Val Glu Glu Glu Gly Ser Cys Glu Ile Leu Tyr 
        275                 280                 285             


Leu Glu Thr Phe Lys Ala His Tyr Asp Ala Ala Phe Ser Ile Asp Asp 
    290                 295                 300                 


Asp Tyr Pro Val Thr Ser His Glu Gln Ile Lys Ala Glu Tyr Val Ala 
305                 310                 315                 320 


Ser Leu Ile Arg Ser Val Tyr Glu Pro Ile Leu Ala Ser His Phe Gly 
                325                 330                 335     


Glu Ala Ile Met Pro Asp Leu Phe His Arg Leu Ala Lys His Ala Ala 
            340                 345                 350         


Lys Val Leu His Met Gly Lys Gly Cys Tyr Asn Asn Leu Ile Ile Ser 
        355                 360                 365             


Leu Ala Lys Lys Pro Glu Lys Ser Asp Val 
    370                 375             


<210>  3
<211>  1155
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DXMT - 3,7-dimethylxanthine N-methyltransferase nucleic acid 
       seuence

<400>  3
atggagctcc aagaagtcct gcatatgaat ggaggcgaag gcgatacaag ctacgccaag       60

aactcatcct acaatctgtt tctcatcagg gtgaaacctg tccttgaaca atgcatacaa      120

gaattgttgc gggccaactt gcccaacatc aacaagtgct ttaaagttgg ggatttggga      180

tgcgcttctg gaccaaacac attttcaaca gttcgggaca ttgtacaaag tattgacaaa      240

gttggccagg aaaagaagaa tgaattagaa cgtcccacca ttcagatttt tctgaatgat      300

cttttccaaa atgatttcaa ttcggttttc aagttgctgc caagcttcta ccgcaatctt      360

gagaaagaaa atggacgcaa aataggatcg tgcctgatag gcgcaatgcc cggctctttc      420

tacagcagac tcttccccga ggagtccatg cattttttac actcttgtta ctgtttgcat      480

tggttatctc aggttcccag cggtttggtg actgaattgg ggatcagtgt gaacaaaggg      540

tgcatttact cttccaaagc aagtcgtccg cccatccaga aggcatattt ggatcaattt      600

acgaaagatt ttaccacatt tctgaggatt cattcggaag agttgatttc acgtggccga      660

atgctcctta ctttcatttg taaagaagat gaattcgacc acccgaattc catggacttg      720

cttgagatgt caataaacga cttggttgtt gagggacatc tggaggaaga aaaattggat      780

agtttcaatg ttccaatcta tgcaccttca acagaagaag taaagcgcat agttgaggag      840

gaaggttctt ttgaaatttt atacctggag actttttatg ccccttatga tgctggcttc      900

tctattgatg atgattacca aggaagatcc cattcccctg tatcctgcga tgaacatgct      960

agagcagcgc atgtggcatc tgtcgttaga tcaatttacg aacccatcct cgcaagtcat     1020

tttggagaag ctattttacc tgacttatcc cacaggattg cgaagaatgc agcaaaggtt     1080

ctccgctcgg gcaaaggctt ctatgatagt gttatcattt ctctcgccaa aaagccggag     1140

aaggcagaca tgtaa                                                      1155


<210>  4
<211>  384
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DXMT - 3,7-dimethylxanthine N-methyltransferase amino acid 
       sequence

<400>  4

Met Glu Leu Gln Glu Val Leu His Met Asn Gly Gly Glu Gly Asp Thr 
1               5                   10                  15      


Ser Tyr Ala Lys Asn Ser Ser Tyr Asn Leu Phe Leu Ile Arg Val Lys 
            20                  25                  30          


Pro Val Leu Glu Gln Cys Ile Gln Glu Leu Leu Arg Ala Asn Leu Pro 
        35                  40                  45              


Asn Ile Asn Lys Cys Phe Lys Val Gly Asp Leu Gly Cys Ala Ser Gly 
    50                  55                  60                  


Pro Asn Thr Phe Ser Thr Val Arg Asp Ile Val Gln Ser Ile Asp Lys 
65                  70                  75                  80  


Val Gly Gln Glu Lys Lys Asn Glu Leu Glu Arg Pro Thr Ile Gln Ile 
                85                  90                  95      


Phe Leu Asn Asp Leu Phe Gln Asn Asp Phe Asn Ser Val Phe Lys Leu 
            100                 105                 110         


Leu Pro Ser Phe Tyr Arg Asn Leu Glu Lys Glu Asn Gly Arg Lys Ile 
        115                 120                 125             


Gly Ser Cys Leu Ile Gly Ala Met Pro Gly Ser Phe Tyr Ser Arg Leu 
    130                 135                 140                 


Phe Pro Glu Glu Ser Met His Phe Leu His Ser Cys Tyr Cys Leu His 
145                 150                 155                 160 


Trp Leu Ser Gln Val Pro Ser Gly Leu Val Thr Glu Leu Gly Ile Ser 
                165                 170                 175     


Val Asn Lys Gly Cys Ile Tyr Ser Ser Lys Ala Ser Arg Pro Pro Ile 
            180                 185                 190         


Gln Lys Ala Tyr Leu Asp Gln Phe Thr Lys Asp Phe Thr Thr Phe Leu 
        195                 200                 205             


Arg Ile His Ser Glu Glu Leu Ile Ser Arg Gly Arg Met Leu Leu Thr 
    210                 215                 220                 


Phe Ile Cys Lys Glu Asp Glu Phe Asp His Pro Asn Ser Met Asp Leu 
225                 230                 235                 240 


Leu Glu Met Ser Ile Asn Asp Leu Val Val Glu Gly His Leu Glu Glu 
                245                 250                 255     


Glu Lys Leu Asp Ser Phe Asn Val Pro Ile Tyr Ala Pro Ser Thr Glu 
            260                 265                 270         


Glu Val Lys Arg Ile Val Glu Glu Glu Gly Ser Phe Glu Ile Leu Tyr 
        275                 280                 285             


Leu Glu Thr Phe Tyr Ala Pro Tyr Asp Ala Gly Phe Ser Ile Asp Asp 
    290                 295                 300                 


Asp Tyr Gln Gly Arg Ser His Ser Pro Val Ser Cys Asp Glu His Ala 
305                 310                 315                 320 


Arg Ala Ala His Val Ala Ser Val Val Arg Ser Ile Tyr Glu Pro Ile 
                325                 330                 335     


Leu Ala Ser His Phe Gly Glu Ala Ile Leu Pro Asp Leu Ser His Arg 
            340                 345                 350         


Ile Ala Lys Asn Ala Ala Lys Val Leu Arg Ser Gly Lys Gly Phe Tyr 
        355                 360                 365             


Asp Ser Val Ile Ile Ser Leu Ala Lys Lys Pro Glu Lys Ala Asp Met 
    370                 375                 380                 


<210>  5
<211>  1158
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DXMT - Probable caffeine synthase 4 nucleic acid sequence

<400>  5
atggagctcc aagaagtcct gcatatgaat ggaggcgaag gcgaagcaag ctacgccaag       60

aattcatcct tcaatcaact ggttctcgcc aaggtgaaac ctgtccttga acaatgcgta      120

cgggaattgt tgcgggccaa cttgcccaac atcaacaagt gcattaaagt tgcagatttg      180

ggatgcgctt ccggaccaaa cacactttta accgttcggg acactgtaca aagtattgac      240

aaagttaggc aagaaatgaa gaatgaatta gaacgtccca ccattcaggt ttttctgact      300

gatcttttcc aaaatgattt caattcggtt ttcatgctgc tgccaagctt ctaccgcaaa      360

cttgagaaag aaaatggacg caaaatagga tcgtgcctaa tagccgcaat gcctggctct      420

ttccacggca gactcttccc cgaggagtcc atgcattttt tacactcttc ttacagtctt      480

cagtttttat cccaggttcc cagcggtttg gtgactgaat tggggatcac tgcgaacaaa      540

aggagcattt actcttccaa agcaagtcct ccgcccgtcc agaaggcata tttggatcaa      600

tttacgaaag attttaccac atttttaagg atgcgttcgg aagagttgct ttcacgtggc      660

cgaatgctcc ttacttgcat ttgtaaagga gatgaatgcg acggcccgaa taccatggac      720

ttacttgaga tggcaataaa cgacttggtt gttgagggac gtctggggga agaaaaattg      780

gacagtttca atgttccaat ctatacagct tcagtagaag aagtaaagtg catggttgag      840

gaggaaggtt cttttgaaat tttatacttg cagactttta agctccgtta tgatgctggc      900

ttctctattg atgatgattg ccaagtaaga tcccattccc cagaatacag cgatgaacat      960

gctagagcag cgcatgtggc atcattaatt agatcagttt acgaacccat cctagcaagt     1020

cattttggag aagctattat acctgacata ttccacaggt ttgcgacgaa tgcagcaaag     1080

gttatccgct tgggcaaagg cttctataat aatcttatca tttctcttgc caaaaaacca     1140

gagaagtcag acatataa                                                   1158


<210>  6
<211>  385
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DXMT - Probable caffeine synthase 4 amino acid sequence

<400>  6

Met Glu Leu Gln Glu Val Leu His Met Asn Gly Gly Glu Gly Glu Ala 
1               5                   10                  15      


Ser Tyr Ala Lys Asn Ser Ser Phe Asn Gln Leu Val Leu Ala Lys Val 
            20                  25                  30          


Lys Pro Val Leu Glu Gln Cys Val Arg Glu Leu Leu Arg Ala Asn Leu 
        35                  40                  45              


Pro Asn Ile Asn Lys Cys Ile Lys Val Ala Asp Leu Gly Cys Ala Ser 
    50                  55                  60                  


Gly Pro Asn Thr Leu Leu Thr Val Arg Asp Thr Val Gln Ser Ile Asp 
65                  70                  75                  80  


Lys Val Arg Gln Glu Met Lys Asn Glu Leu Glu Arg Pro Thr Ile Gln 
                85                  90                  95      


Val Phe Leu Thr Asp Leu Phe Gln Asn Asp Phe Asn Ser Val Phe Met 
            100                 105                 110         


Leu Leu Pro Ser Phe Tyr Arg Lys Leu Glu Lys Glu Asn Gly Arg Lys 
        115                 120                 125             


Ile Gly Ser Cys Leu Ile Ala Ala Met Pro Gly Ser Phe His Gly Arg 
    130                 135                 140                 


Leu Phe Pro Glu Glu Ser Met His Phe Leu His Ser Ser Tyr Ser Leu 
145                 150                 155                 160 


Gln Phe Leu Ser Gln Val Pro Ser Gly Leu Val Thr Glu Leu Gly Ile 
                165                 170                 175     


Thr Ala Asn Lys Arg Ser Ile Tyr Ser Ser Lys Ala Ser Pro Pro Pro 
            180                 185                 190         


Val Gln Lys Ala Tyr Leu Asp Gln Phe Thr Lys Asp Phe Thr Thr Phe 
        195                 200                 205             


Leu Arg Met Arg Ser Glu Glu Leu Leu Ser Arg Gly Arg Met Leu Leu 
    210                 215                 220                 


Thr Cys Ile Cys Lys Gly Asp Glu Cys Asp Gly Pro Asn Thr Met Asp 
225                 230                 235                 240 


Leu Leu Glu Met Ala Ile Asn Asp Leu Val Val Glu Gly Arg Leu Gly 
                245                 250                 255     


Glu Glu Lys Leu Asp Ser Phe Asn Val Pro Ile Tyr Thr Ala Ser Val 
            260                 265                 270         


Glu Glu Val Lys Cys Met Val Glu Glu Glu Gly Ser Phe Glu Ile Leu 
        275                 280                 285             


Tyr Leu Gln Thr Phe Lys Leu Arg Tyr Asp Ala Gly Phe Ser Ile Asp 
    290                 295                 300                 


Asp Asp Cys Gln Val Arg Ser His Ser Pro Glu Tyr Ser Asp Glu His 
305                 310                 315                 320 


Ala Arg Ala Ala His Val Ala Ser Leu Ile Arg Ser Val Tyr Glu Pro 
                325                 330                 335     


Ile Leu Ala Ser His Phe Gly Glu Ala Ile Ile Pro Asp Ile Phe His 
            340                 345                 350         


Arg Phe Ala Thr Asn Ala Ala Lys Val Ile Arg Leu Gly Lys Gly Phe 
        355                 360                 365             


Tyr Asn Asn Leu Ile Ile Ser Leu Ala Lys Lys Pro Glu Lys Ser Asp 
    370                 375                 380                 


Ile 
385 


<210>  7
<211>  1158
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MXMT - Theobromine synthase 2 nucleic acid sequence

<400>  7
atggagctcc aagaagtcct gcatatgaat ggaggcgaag gcgatacaag ctacgccaag       60

aattcatcgt acaatcaact ggttctcacc aaggtgaaac ctgtccttga acaatgcata      120

cgagaattgt tgcgggccaa cttgcccaac atcaacaagt gcattaaagt tgcggatttg      180

ggatgcgctt ctggaccaaa cacactttta acagttcggg acattgtgca aagtattgac      240

aaagttggcc aggaagagaa gaatgaatta gaacatccca ccattcaaat ttttctgaat      300

gatcttttcc aaaatgattt caattcagtt ttcaagttgc tgccaagctt ctaccgcaaa      360

ctcgagaaag aaaatggacg caaaatagga tcgtgcctaa taagcgcaat gcctggctct      420

ttctacggca gactcttccc cgaggagtcc atgcattttt tgcactcttg ttacagtgtt      480

cattggttat ctcaggttcc cagcggattg gtgactgaac tggggatcag tgcgaacaaa      540

gggatcattt actcttccaa agcaagtcct ccgcccgtcc agaaggcata tttggaccaa      600

tttacaaaag attttaccac atttctgagg attcattcgg aagagttgct ttcaggtggc      660

cgaatgctcc ttacttgcat ttgtaaagga gatgaatccg atggcctgaa taccatagac      720

ttacttgaga gagcaataaa cgacttggtt gttgagggac ttctggagga agaaaaattg      780

gatagtttca atcttccact ctatacacct tcactagaag tagtaaagtg catagttgag      840

gaggaaggtt cttttgaaat tttatacctg gagactttta aggtccgtta tgatgctggc      900

ttctctattg atgatgatta ccaagtaaga tcccttttcc aagtatactg cgatgaacat      960

gttaaagcag cgtatgtgac attcttcttt agagcagttt tcgaacccat cctcgcaagt     1020

cattttggag aagctattat gcctgactta ttccacaggt ttgcgaagaa tgcagcaaag     1080

gctctccgct tgggcaacgg cttctataat agtcttatca tttctcttgc caaaaaacca     1140

gagaagtcag acatgtaa                                                   1158


<210>  8
<211>  385
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MXMT - Theobromine synthase 2 amino acid sequence

<400>  8

Met Glu Leu Gln Glu Val Leu His Met Asn Gly Gly Glu Gly Asp Thr 
1               5                   10                  15      


Ser Tyr Ala Lys Asn Ser Ser Tyr Asn Gln Leu Val Leu Thr Lys Val 
            20                  25                  30          


Lys Pro Val Leu Glu Gln Cys Ile Arg Glu Leu Leu Arg Ala Asn Leu 
        35                  40                  45              


Pro Asn Ile Asn Lys Cys Ile Lys Val Ala Asp Leu Gly Cys Ala Ser 
    50                  55                  60                  


Gly Pro Asn Thr Leu Leu Thr Val Arg Asp Ile Val Gln Ser Ile Asp 
65                  70                  75                  80  


Lys Val Gly Gln Glu Glu Lys Asn Glu Leu Glu His Pro Thr Ile Gln 
                85                  90                  95      


Ile Phe Leu Asn Asp Leu Phe Gln Asn Asp Phe Asn Ser Val Phe Lys 
            100                 105                 110         


Leu Leu Pro Ser Phe Tyr Arg Lys Leu Glu Lys Glu Asn Gly Arg Lys 
        115                 120                 125             


Ile Gly Ser Cys Leu Ile Ser Ala Met Pro Gly Ser Phe Tyr Gly Arg 
    130                 135                 140                 


Leu Phe Pro Glu Glu Ser Met His Phe Leu His Ser Cys Tyr Ser Val 
145                 150                 155                 160 


His Trp Leu Ser Gln Val Pro Ser Gly Leu Val Thr Glu Leu Gly Ile 
                165                 170                 175     


Ser Ala Asn Lys Gly Ile Ile Tyr Ser Ser Lys Ala Ser Pro Pro Pro 
            180                 185                 190         


Val Gln Lys Ala Tyr Leu Asp Gln Phe Thr Lys Asp Phe Thr Thr Phe 
        195                 200                 205             


Leu Arg Ile His Ser Glu Glu Leu Leu Ser Gly Gly Arg Met Leu Leu 
    210                 215                 220                 


Thr Cys Ile Cys Lys Gly Asp Glu Ser Asp Gly Leu Asn Thr Ile Asp 
225                 230                 235                 240 


Leu Leu Glu Arg Ala Ile Asn Asp Leu Val Val Glu Gly Leu Leu Glu 
                245                 250                 255     


Glu Glu Lys Leu Asp Ser Phe Asn Leu Pro Leu Tyr Thr Pro Ser Leu 
            260                 265                 270         


Glu Val Val Lys Cys Ile Val Glu Glu Glu Gly Ser Phe Glu Ile Leu 
        275                 280                 285             


Tyr Leu Glu Thr Phe Lys Val Arg Tyr Asp Ala Gly Phe Ser Ile Asp 
    290                 295                 300                 


Asp Asp Tyr Gln Val Arg Ser Leu Phe Gln Val Tyr Cys Asp Glu His 
305                 310                 315                 320 


Val Lys Ala Ala Tyr Val Thr Phe Phe Phe Arg Ala Val Phe Glu Pro 
                325                 330                 335     


Ile Leu Ala Ser His Phe Gly Glu Ala Ile Met Pro Asp Leu Phe His 
            340                 345                 350         


Arg Phe Ala Lys Asn Ala Ala Lys Ala Leu Arg Leu Gly Asn Gly Phe 
        355                 360                 365             


Tyr Asn Ser Leu Ile Ile Ser Leu Ala Lys Lys Pro Glu Lys Ser Asp 
    370                 375                 380                 


Met 
385 


<210>  9
<211>  1119
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT - 7-methylxanthosine synthase 1 nucleic acid sequence

<400>  9
atggagctcc aagaagtcct gcggatgaat ggaggcgaag gcgatacaag ctacgccaag       60

aattcagcct acaatcaact ggttctcgcc aaggtgaaac ctgtccttga acaatgcgta      120

cgggaattgt tgcgggccaa cttgcccaac atcaacaagt gcattaaagt tgcggatttg      180

ggatgcgctt ctggaccaaa cacactttta acagttcggg acattgtcca aagtattgac      240

aaagttggcc aggaaaagaa gaatgaatta gaacgtccca ccattcagat ttttctgaat      300

gatcttttcc caaatgattt caattcggtt ttcaagttgc tgccaagctt ctaccgcaaa      360

cttgagaaag aaaatggacg caaaatagga tcgtgcctaa taggggcaat gcccggctct      420

ttctacagca gactcttccc cgaggagtcc atgcattttt tacactcttg ttactgtctt      480

caatggttat ctcaggttcc tagcggtttg gtgactgaat cggggatcag tacgaacaaa      540

gggagcattt actcttccaa agcaagtcgt ctgcccgtcc agaaggcata tttggatcaa      600

tttacgaaag attttaccac atttctaagg attcattcgg aagagttgtt ttcacatggc      660

cgaatgctcc ttacttgcat ttgtaaagga gttgaattag acgcccggaa tgccatagac      720

ttacttgaga tggcaataaa cgacttggtt gttgagggac atctggagga agaaaaattg      780

gatagtttca atcttccagt ctatatacct tcagcagaag aagtaaagtg catagttgag      840

gaggaaggtt cttttgaaat tttatacctg gagactttta aggtccttta cgatgctggc      900

ttctctattg acgatgaaca tattaaagca gagtatgttg catcttccgt tagagcagtt      960

tacgaaccca tcctcgcaag tcattttgga gaagctatta tacctgacat attccacagg     1020

tttgcgaagc atgcagcaaa ggttctcccc ttgggcaaag gcttctataa taatcttatc     1080

atttctctcg ccaaaaagcc agagaagtca gacgtgtaa                            1119


<210>  10
<211>  372
<212>  PRT
<213>  Artificial sequence

<220>
<223>  XMT - 7-methylxanthosine synthase 1 amino acid sequence

<400>  10

Met Glu Leu Gln Glu Val Leu Arg Met Asn Gly Gly Glu Gly Asp Thr 
1               5                   10                  15      


Ser Tyr Ala Lys Asn Ser Ala Tyr Asn Gln Leu Val Leu Ala Lys Val 
            20                  25                  30          


Lys Pro Val Leu Glu Gln Cys Val Arg Glu Leu Leu Arg Ala Asn Leu 
        35                  40                  45              


Pro Asn Ile Asn Lys Cys Ile Lys Val Ala Asp Leu Gly Cys Ala Ser 
    50                  55                  60                  


Gly Pro Asn Thr Leu Leu Thr Val Arg Asp Ile Val Gln Ser Ile Asp 
65                  70                  75                  80  


Lys Val Gly Gln Glu Lys Lys Asn Glu Leu Glu Arg Pro Thr Ile Gln 
                85                  90                  95      


Ile Phe Leu Asn Asp Leu Phe Pro Asn Asp Phe Asn Ser Val Phe Lys 
            100                 105                 110         


Leu Leu Pro Ser Phe Tyr Arg Lys Leu Glu Lys Glu Asn Gly Arg Lys 
        115                 120                 125             


Ile Gly Ser Cys Leu Ile Gly Ala Met Pro Gly Ser Phe Tyr Ser Arg 
    130                 135                 140                 


Leu Phe Pro Glu Glu Ser Met His Phe Leu His Ser Cys Tyr Cys Leu 
145                 150                 155                 160 


Gln Trp Leu Ser Gln Val Pro Ser Gly Leu Val Thr Glu Ser Gly Ile 
                165                 170                 175     


Ser Thr Asn Lys Gly Ser Ile Tyr Ser Ser Lys Ala Ser Arg Leu Pro 
            180                 185                 190         


Val Gln Lys Ala Tyr Leu Asp Gln Phe Thr Lys Asp Phe Thr Thr Phe 
        195                 200                 205             


Leu Arg Ile His Ser Glu Glu Leu Phe Ser His Gly Arg Met Leu Leu 
    210                 215                 220                 


Thr Cys Ile Cys Lys Gly Val Glu Leu Asp Ala Arg Asn Ala Ile Asp 
225                 230                 235                 240 


Leu Leu Glu Met Ala Ile Asn Asp Leu Val Val Glu Gly His Leu Glu 
                245                 250                 255     


Glu Glu Lys Leu Asp Ser Phe Asn Leu Pro Val Tyr Ile Pro Ser Ala 
            260                 265                 270         


Glu Glu Val Lys Cys Ile Val Glu Glu Glu Gly Ser Phe Glu Ile Leu 
        275                 280                 285             


Tyr Leu Glu Thr Phe Lys Val Leu Tyr Asp Ala Gly Phe Ser Ile Asp 
    290                 295                 300                 


Asp Glu His Ile Lys Ala Glu Tyr Val Ala Ser Ser Val Arg Ala Val 
305                 310                 315                 320 


Tyr Glu Pro Ile Leu Ala Ser His Phe Gly Glu Ala Ile Ile Pro Asp 
                325                 330                 335     


Ile Phe His Arg Phe Ala Lys His Ala Ala Lys Val Leu Pro Leu Gly 
            340                 345                 350         


Lys Gly Phe Tyr Asn Asn Leu Ile Ile Ser Leu Ala Lys Lys Pro Glu 
        355                 360                 365             


Lys Ser Asp Val 
    370         


<210>  11
<211>  1119
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DXMT - Probable caffeine synthase 3 nucleic acid sequence

<400>  11
atggaactcc aacgagtcct gcacatgagt ggaggcgaag gcgatacaag ctacgccaaa       60

aattcatcct accaagtgaa gcctgtactt gaacaatgca tacaagaatt gttgcggacc      120

aacttaccct acgacgagaa gtgcattaga gttgctgatt tgggatgctc ttcaggacca      180

aacacactat taacagtttc ggacatcata caaagtattg acaaagttag ccaggaaatg      240

gacaatgaat ttgcactgcc cacgattcag gtttttctga atgatctttt cgaaaatgat      300

ttcaatacgg ttatcaagtc gctgccaagc ttctaccgca aacttgaaaa agaaaatgga      360

cgcaaaatag gatcgtgcct gatagcagca atgcctggct ctttctacgg cagactcttc      420

cccgagcagt ccgtccattt tttacactct tcttacagtc tccattggtt atctcaggtt      480

cccaatggtt tggtgactga atcggggatc agtgcgaata aagggagcat ttactcttcc      540

aaagcaagtc ctccggccat ccagaaggca tatttggatc aatttacgaa agattttacc      600

acatttctca ggatgcattc ggaagagttg gtttcacatg gccgaatcct cctcactttc      660

atgtgtaaag gagatgaatt cgacggccca aatatcttag acttacttga ggtggcaata      720

aacgacttgg ttgtcgaggg aagtctggag gaagaaaaac tggacagttt caatgttcca      780

atctatgcgc cttcagtaga agaagtcagg cacataattg aggaggaacg ttcttttgaa      840

attgtatacc tggagacgtt taagctccgt catgatgctg gcttctccat tgatgataac      900

caagcagccc atgtggcatc attcgttaga gcagcttggg aacctatcct agcaagccat      960

tttggagaag ctattatagc cgacttattc cacaggtttg ccaagaatgc agcaacgcct     1020

ctccgcatgg gcaaaggctt ctttaataat ctcatcattt ctctcgccaa gaaaccacac     1080

aagtcagaga catgtaaata tttgttttta gatatgtag                            1119


<210>  12
<211>  387
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DXMT - Probable caffeine synthase 3 amino acid sequence

<400>  12

Met Glu Leu Gln Arg Val Leu His Met Ser Gly Gly Glu Gly Asp Thr 
1               5                   10                  15      


Ser Tyr Ala Lys Asn Ser Ser Tyr Gln Val Lys Pro Val Leu Glu Gln 
            20                  25                  30          


Cys Ile Gln Glu Leu Leu Arg Thr Asn Leu Pro Tyr Asp Glu Lys Cys 
        35                  40                  45              


Ile Arg Val Ala Asp Leu Gly Cys Ser Ser Gly Pro Asn Thr Leu Leu 
    50                  55                  60                  


Thr Val Ser Asp Ile Ile Gln Ser Ile Asp Lys Val Ser Gln Glu Met 
65                  70                  75                  80  


Asp Asn Glu Phe Ala Leu Pro Thr Ile Gln Val Phe Leu Asn Asp Leu 
                85                  90                  95      


Phe Glu Asn Asp Phe Asn Thr Val Ile Lys Ser Leu Pro Ser Phe Tyr 
            100                 105                 110         


Arg Lys Leu Glu Lys Glu Asn Gly Arg Lys Ile Gly Ser Cys Leu Ile 
        115                 120                 125             


Ala Ala Met Pro Gly Ser Phe Tyr Gly Arg Leu Phe Pro Glu Gln Ser 
    130                 135                 140                 


Val His Phe Leu His Ser Ser Tyr Ser Leu His Trp Leu Ser Gln Val 
145                 150                 155                 160 


Pro Asn Gly Leu Val Thr Glu Ser Gly Ile Ser Ala Asn Lys Gly Ser 
                165                 170                 175     


Ile Tyr Ser Ser Lys Ala Ser Pro Pro Ala Ile Gln Lys Ala Tyr Leu 
            180                 185                 190         


Asp Gln Phe Thr Lys Asp Phe Thr Thr Phe Leu Arg Met His Ser Glu 
        195                 200                 205             


Glu Leu Val Ser His Gly Arg Ile Leu Leu Thr Phe Met Cys Lys Gly 
    210                 215                 220                 


Asp Glu Phe Asp Gly Pro Asn Ile Leu Asp Leu Leu Glu Val Ala Ile 
225                 230                 235                 240 


Asn Asp Leu Val Val Glu Gly Ser Leu Glu Glu Glu Lys Leu Asp Ser 
                245                 250                 255     


Phe Asn Val Pro Ile Tyr Ala Pro Ser Val Glu Glu Val Arg His Ile 
            260                 265                 270         


Ile Glu Glu Glu Arg Ser Phe Glu Ile Val Tyr Leu Glu Thr Phe Lys 
        275                 280                 285             


Leu Arg His Asp Ala Gly Phe Ser Ile Asp Asp Asn Gln Leu Gly Ser 
    290                 295                 300                 


His Ser Gln Val Arg Phe Cys Asp Glu His Val Arg Ala Ala His Val 
305                 310                 315                 320 


Ala Ser Phe Val Arg Ala Ala Trp Glu Pro Ile Leu Ala Ser His Phe 
                325                 330                 335     


Gly Glu Ala Ile Ile Ala Asp Leu Phe His Arg Phe Ala Lys Asn Ala 
            340                 345                 350         


Ala Thr Pro Leu Arg Met Gly Lys Gly Phe Phe Asn Asn Leu Ile Ile 
        355                 360                 365             


Ser Leu Ala Lys Lys Pro His Lys Ser Glu Thr Cys Lys Tyr Leu Phe 
    370                 375                 380                 


Leu Asp Met 
385         


<210>  13
<211>  1155
<212>  DNA
<213>  Coffea arabica

<400>  13
atggagctcc aagaagtcct gcatatgaat ggaggcgaag gcgatacaag ctacgccaag       60

aactcattct acaatctgtt tctcatcagg gtgaaaccta tccttgaaca atgcatacaa      120

gaattgttgc gggccaactt gcccaacatc aacaagtgca ttaaagttgc ggatttggga      180

tgcgcttctg gaccaaacac acttttaaca gttcgggaca ttgtacaaag tattgacaaa      240

gttggccagg aaaagaagaa tgaattagaa cgtcccacca ttcagatttt tctgaatgat      300

cttttccaaa atgatttcaa ttcggttttc aagtcgctgc caagcttcta ccgcaaactt      360

gagaaagaaa atggacgcaa aataggatca tgcctgatag gcgcaatgcc tggctctttc      420

tacggcagac tcttccccga ggagtccatg cattttttac actcttgtta ctgtttgcat      480

tggttatctc aggttcccag cggtttggtg actgaattgg ggatcagtgc gaacaaaggg      540

tgcatttact cttccaaagc aagtcgtccg cccatccaga aggcatattt ggatcaattt      600

acgaaagatt ttaccacatt tcttaggatt cattcggaag agttgatttc acgtggccga      660

atgctcctta cttggatttg caaagaagat gaattcgaga acccgaattc catagactta      720

cttgagatgt caataaacga cttggttatt gagggacatc tggaggaaga aaaattggac      780

agtttcaatg ttccaatcta tgcaccttca acagaagaag taaagtgcat agttgaggag      840

gaaggttctt ttgaaatttt atacctggag acttttaagg tcccttatga tgctggcttc      900

tctattgatg atgattacca aggaagatcc cattccccag tatcctgcga tgaacatgct      960

agagcagcgc atgtggcatc tgtcgttaga tcaattttcg aacccatcgt cgcaagtcat     1020

tttggagaag ctatcatgcc tgacttatcc cacaggattg cgaagaatgc agcaaaggtt     1080

cttcgctccg gcaaaggctt ctatgatagt cttatcattt ctctcgccaa aaagccagag     1140

aagtcagacg tgtaa                                                      1155


<210>  14
<211>  384
<212>  PRT
<213>  Coffea arabica

<400>  14

Met Glu Leu Gln Glu Val Leu His Met Asn Gly Gly Glu Gly Asp Thr 
1               5                   10                  15      


Ser Tyr Ala Lys Asn Ser Phe Tyr Asn Leu Phe Leu Ile Arg Val Lys 
            20                  25                  30          


Pro Ile Leu Glu Gln Cys Ile Gln Glu Leu Leu Arg Ala Asn Leu Pro 
        35                  40                  45              


Asn Ile Asn Lys Cys Ile Lys Val Ala Asp Leu Gly Cys Ala Ser Gly 
    50                  55                  60                  


Pro Asn Thr Leu Leu Thr Val Arg Asp Ile Val Gln Ser Ile Asp Lys 
65                  70                  75                  80  


Val Gly Gln Glu Lys Lys Asn Glu Leu Glu Arg Pro Thr Ile Gln Ile 
                85                  90                  95      


Phe Leu Asn Asp Leu Phe Gln Asn Asp Phe Asn Ser Val Phe Lys Ser 
            100                 105                 110         


Leu Pro Ser Phe Tyr Arg Lys Leu Glu Lys Glu Asn Gly Arg Lys Ile 
        115                 120                 125             


Gly Ser Cys Leu Ile Gly Ala Met Pro Gly Ser Phe Tyr Gly Arg Leu 
    130                 135                 140                 


Phe Pro Glu Glu Ser Met His Phe Leu His Ser Cys Tyr Cys Leu His 
145                 150                 155                 160 


Trp Leu Ser Gln Val Pro Ser Gly Leu Val Thr Glu Leu Gly Ile Ser 
                165                 170                 175     


Ala Asn Lys Gly Cys Ile Tyr Ser Ser Lys Ala Ser Arg Pro Pro Ile 
            180                 185                 190         


Gln Lys Ala Tyr Leu Asp Gln Phe Thr Lys Asp Phe Thr Thr Phe Leu 
        195                 200                 205             


Arg Ile His Ser Glu Glu Leu Ile Ser Arg Gly Arg Met Leu Leu Thr 
    210                 215                 220                 


Trp Ile Cys Lys Glu Asp Glu Phe Glu Asn Pro Asn Ser Ile Asp Leu 
225                 230                 235                 240 


Leu Glu Met Ser Ile Asn Asp Leu Val Ile Glu Gly His Leu Glu Glu 
                245                 250                 255     


Glu Lys Leu Asp Ser Phe Asn Val Pro Ile Tyr Ala Pro Ser Thr Glu 
            260                 265                 270         


Glu Val Lys Cys Ile Val Glu Glu Glu Gly Ser Phe Glu Ile Leu Tyr 
        275                 280                 285             


Leu Glu Thr Phe Lys Val Pro Tyr Asp Ala Gly Phe Ser Ile Asp Asp 
    290                 295                 300                 


Asp Tyr Gln Gly Arg Ser His Ser Pro Val Ser Cys Asp Glu His Ala 
305                 310                 315                 320 


Arg Ala Ala His Val Ala Ser Val Val Arg Ser Ile Phe Glu Pro Ile 
                325                 330                 335     


Val Ala Ser His Phe Gly Glu Ala Ile Met Pro Asp Leu Ser His Arg 
            340                 345                 350         


Ile Ala Lys Asn Ala Ala Lys Val Leu Arg Ser Gly Lys Gly Phe Tyr 
        355                 360                 365             


Asp Ser Leu Ile Ile Ser Leu Ala Lys Lys Pro Glu Lys Ser Asp Val 
    370                 375                 380                 


<210>  15
<211>  1155
<212>  DNA
<213>  Coffea canephora

<400>  15
atggagctcc aagaagtcct gcatatgaat ggaggcgaag gcgatacaag ctacgccaag       60

aactcatcct acaatctgtt tctcatcagg gtgaaacctg tccttgaaca atgcatacaa      120

gaattgttgc gggccaactt gcccaacatc aacaagtgct ttaaagttgg ggatttggga      180

tgcgcttctg gaccaaacac attttcaaca gttcgggaca ttgtacaaag tattgacaaa      240

gttggccagg aaaagaagaa tgaattagaa cgtcccacca ttcagatttt tctgaatgat      300

cttttccaaa atgatttcaa ttcggttttc aagttgctgc caagcttcta ccgcaatctt      360

gagaaagaaa atggacgcaa aataggatcg tgcctgatag gcgcaatgcc cggctctttc      420

tacagcagac tcttccccga ggagtccatg cattttttac actcttgtta ctgtttgcat      480

tggttatctc aggttcccag cggtttggtg actgaattgg ggatcagtgt gaacaaaggg      540

tgcatttact cttccaaagc aagtcgtccg cccatccaga aggcatattt ggatcaattt      600

acgaaagatt ttaccacatt tcttaggatt cattcggaag agttgatttc acgtggccga      660

atgctcctta ctttcatttg taaagaagat gaattcgacc acccgaattc catggacttg      720

cttgagatgt caataaacga cttggttatt gagggacatc tggaggaaga aaaattggat      780

agcttcaatg ttccaatcta tgcaccttca acagaagaag taaagcgcat agttgaggag      840

gaaggttctt ttgaaatttt atacctggag acttttaatg ccccttatga tgctggcttc      900

tctattgatg atgattacca aggaagatcc cattcccctg tatcctgcga tgaacatgct      960

agagcagcgc atgtggcatc tgtcgttaga tcaatttacg aacccatcct cgcgagtcat     1020

tttggagaag ctattttacc tgacttatcc cacaggattg cgaagaatgc agcaaaggtt     1080

ctccgctcgg gcaaaggctt ctatgatagt gttatcattt ctctcgccaa aaagccggag     1140

aaggcagaca tgtaa                                                      1155


<210>  16
<211>  384
<212>  PRT
<213>  Coffea canephora

<400>  16

Met Glu Leu Gln Glu Val Leu His Met Asn Gly Gly Glu Gly Asp Thr 
1               5                   10                  15      


Ser Tyr Ala Lys Asn Ser Ser Tyr Asn Leu Phe Leu Ile Arg Val Lys 
            20                  25                  30          


Pro Val Leu Glu Gln Cys Ile Gln Glu Leu Leu Arg Ala Asn Leu Pro 
        35                  40                  45              


Asn Ile Asn Lys Cys Phe Lys Val Gly Asp Leu Gly Cys Ala Ser Gly 
    50                  55                  60                  


Pro Asn Thr Phe Ser Thr Val Arg Asp Ile Val Gln Ser Ile Asp Lys 
65                  70                  75                  80  


Val Gly Gln Glu Lys Lys Asn Glu Leu Glu Arg Pro Thr Ile Gln Ile 
                85                  90                  95      


Phe Leu Asn Asp Leu Phe Gln Asn Asp Phe Asn Ser Val Phe Lys Leu 
            100                 105                 110         


Leu Pro Ser Phe Tyr Arg Asn Leu Glu Lys Glu Asn Gly Arg Lys Ile 
        115                 120                 125             


Gly Ser Cys Leu Ile Gly Ala Met Pro Gly Ser Phe Tyr Ser Arg Leu 
    130                 135                 140                 


Phe Pro Glu Glu Ser Met His Phe Leu His Ser Cys Tyr Cys Leu His 
145                 150                 155                 160 


Trp Leu Ser Gln Val Pro Ser Gly Leu Val Thr Glu Leu Gly Ile Ser 
                165                 170                 175     


Val Asn Lys Gly Cys Ile Tyr Ser Ser Lys Ala Ser Arg Pro Pro Ile 
            180                 185                 190         


Gln Lys Ala Tyr Leu Asp Gln Phe Thr Lys Asp Phe Thr Thr Phe Leu 
        195                 200                 205             


Arg Ile His Ser Glu Glu Leu Ile Ser Arg Gly Arg Met Leu Leu Thr 
    210                 215                 220                 


Phe Ile Cys Lys Glu Asp Glu Phe Asp His Pro Asn Ser Met Asp Leu 
225                 230                 235                 240 


Leu Glu Met Ser Ile Asn Asp Leu Val Ile Glu Gly His Leu Glu Glu 
                245                 250                 255     


Glu Lys Leu Asp Ser Phe Asn Val Pro Ile Tyr Ala Pro Ser Thr Glu 
            260                 265                 270         


Glu Val Lys Arg Ile Val Glu Glu Glu Gly Ser Phe Glu Ile Leu Tyr 
        275                 280                 285             


Leu Glu Thr Phe Asn Ala Pro Tyr Asp Ala Gly Phe Ser Ile Asp Asp 
    290                 295                 300                 


Asp Tyr Gln Gly Arg Ser His Ser Pro Val Ser Cys Asp Glu His Ala 
305                 310                 315                 320 


Arg Ala Ala His Val Ala Ser Val Val Arg Ser Ile Tyr Glu Pro Ile 
                325                 330                 335     


Leu Ala Ser His Phe Gly Glu Ala Ile Leu Pro Asp Leu Ser His Arg 
            340                 345                 350         


Ile Ala Lys Asn Ala Ala Lys Val Leu Arg Ser Gly Lys Gly Phe Tyr 
        355                 360                 365             


Asp Ser Val Ile Ile Ser Leu Ala Lys Lys Pro Glu Lys Ala Asp Met 
    370                 375                 380                 


<210>  17
<211>  1119
<212>  DNA
<213>  Coffea arabica

<400>  17
atggagctcc aagaagtcct gcggatgaat ggaggcgaag gcgatacaag ctacgccaag       60

aattcagcct acaatcaact ggttctcgcc aaggtgaaac ctgtccttga acaatgcgta      120

cgggaattgt tgcgggccaa cttgcccaac atcaacaagt gcattaaagt tgcggatttg      180

ggatgcgctt ctggaccaaa cacactttta acagttcggg acattgtcca aagtattgac      240

aaagttggcc aggaaaagaa gaatgaatta gaacgtccca ccattcagat ttttctgaat      300

gatcttttcc caaatgattt caattcggtt ttcaagttgc tgccaagctt ctaccgcaaa      360

cttgagaaag aaaatggacg caaaatagga tcgtgcctaa taggggcaat gcccggctct      420

ttctacagca gactcttccc cgaggagtcc atgcattttt tacactcttg ttactgtctt      480

caatggttat ctcaggttcc tagcggtttg gtgactgaat tggggatcag tacgaacaaa      540

gggagcattt actcttccaa agcaagtcgt ctgcccgtcc agaaggcata tttggatcaa      600

tttacgaaag attttaccac atttctaagg attcattcgg aagagttgtt ttcacatggc      660

cgaatgctcc ttacttgcat ttgtaaagga gttgaattag acgcccggaa tgccatagac      720

ttacttgaga tggcaataaa cgacttggtt gttgagggac atctggagga agaaaaattg      780

gatagtttca atcttccagt ctatatacct tcagcagaag aagtaaagtg catagttgag      840

gaggaaggtt cttttgaaat tttatacctg gagactttta aggtccttta cgatgctggc      900

ttctctattg acgatgaaca tattaaagca gagtatgttg catcttccgt tagagcagtt      960

tacgaaccca tcctcgcaag tcattttgga gaagctatta tacctgacat attccacagg     1020

tttgcgaagc atgcagcaaa ggttctcccc ttgggcaaag gcttctataa taatcttatc     1080

atttctctcg ccaaaaagcc agagaagtca gacgtgtaa                            1119


<210>  18
<211>  372
<212>  PRT
<213>  Coffea arabica

<400>  18

Met Glu Leu Gln Glu Val Leu Arg Met Asn Gly Gly Glu Gly Asp Thr 
1               5                   10                  15      


Ser Tyr Ala Lys Asn Ser Ala Tyr Asn Gln Leu Val Leu Ala Lys Val 
            20                  25                  30          


Lys Pro Val Leu Glu Gln Cys Val Arg Glu Leu Leu Arg Ala Asn Leu 
        35                  40                  45              


Pro Asn Ile Asn Lys Cys Ile Lys Val Ala Asp Leu Gly Cys Ala Ser 
    50                  55                  60                  


Gly Pro Asn Thr Leu Leu Thr Val Arg Asp Ile Val Gln Ser Ile Asp 
65                  70                  75                  80  


Lys Val Gly Gln Glu Lys Lys Asn Glu Leu Glu Arg Pro Thr Ile Gln 
                85                  90                  95      


Ile Phe Leu Asn Asp Leu Phe Pro Asn Asp Phe Asn Ser Val Phe Lys 
            100                 105                 110         


Leu Leu Pro Ser Phe Tyr Arg Lys Leu Glu Lys Glu Asn Gly Arg Lys 
        115                 120                 125             


Ile Gly Ser Cys Leu Ile Gly Ala Met Pro Gly Ser Phe Tyr Ser Arg 
    130                 135                 140                 


Leu Phe Pro Glu Glu Ser Met His Phe Leu His Ser Cys Tyr Cys Leu 
145                 150                 155                 160 


Gln Trp Leu Ser Gln Val Pro Ser Gly Leu Val Thr Glu Leu Gly Ile 
                165                 170                 175     


Ser Thr Asn Lys Gly Ser Ile Tyr Ser Ser Lys Ala Ser Arg Leu Pro 
            180                 185                 190         


Val Gln Lys Ala Tyr Leu Asp Gln Phe Thr Lys Asp Phe Thr Thr Phe 
        195                 200                 205             


Leu Arg Ile His Ser Glu Glu Leu Phe Ser His Gly Arg Met Leu Leu 
    210                 215                 220                 


Thr Cys Ile Cys Lys Gly Val Glu Leu Asp Ala Arg Asn Ala Ile Asp 
225                 230                 235                 240 


Leu Leu Glu Met Ala Ile Asn Asp Leu Val Val Glu Gly His Leu Glu 
                245                 250                 255     


Glu Glu Lys Leu Asp Ser Phe Asn Leu Pro Val Tyr Ile Pro Ser Ala 
            260                 265                 270         


Glu Glu Val Lys Cys Ile Val Glu Glu Glu Gly Ser Phe Glu Ile Leu 
        275                 280                 285             


Tyr Leu Glu Thr Phe Lys Val Leu Tyr Asp Ala Gly Phe Ser Ile Asp 
    290                 295                 300                 


Asp Glu His Ile Lys Ala Glu Tyr Val Ala Ser Ser Val Arg Ala Val 
305                 310                 315                 320 


Tyr Glu Pro Ile Leu Ala Ser His Phe Gly Glu Ala Ile Ile Pro Asp 
                325                 330                 335     


Ile Phe His Arg Phe Ala Lys His Ala Ala Lys Val Leu Pro Leu Gly 
            340                 345                 350         


Lys Gly Phe Tyr Asn Asn Leu Ile Ile Ser Leu Ala Lys Lys Pro Glu 
        355                 360                 365             


Lys Ser Asp Val 
    370         


<210>  19
<211>  1119
<212>  DNA
<213>  Coffea canephora

<400>  19
atggagctcc aagaagtcct gcggatgaat ggaggcgaag gcgatacaag ctacgccaag       60

aattcagcct acaatcaact ggttctcgcc aaggtgaaac ctgtccttga acaatgcgta      120

cgggaattgt tgcgggccaa cttgcccaac atcaacaagt gcattaaagt tgcggatttg      180

ggatgcgctt ctggaccaaa cacactttta acggttcggg acattgtcca aagtattgac      240

aaagttggcc aggaaaagaa gaatgaatta gaacgtccca ccattcagat ttttctgaat      300

gatcttttcc caaatgattt caattcggtt ttcaagttgc tgccaagctt ctaccgcaaa      360

cttgagaaag aaaatggacg caaaatagga tcgtgcctaa taggggcaat gcccggctct      420

ttctacagca gactcttccc cgaggagtcc atgcattttt tacactcttg ttactgtctt      480

caatggttat ctcaggttcc tagcggtttg gtgactgaat tggggatcgg cacgaacaaa      540

gggagcattt actcttccaa agcaagtcgt ctgcccgtcc agaaggcata tttggatcaa      600

tttacgaaag attttaccac atttctaagg attcattcgg aagagttgtt ttcacatggc      660

cgaatgctcc ttacttgcat ttgtaaagga gttgaattag acgcccggaa tgccatagac      720

ttacttgaga tggcaataaa cgacttggtt gttgagggac atctggagga agaaaaattg      780

gatagtttca atcttccagt ctatatacct tcagcagaag aagtaaagtg catagttgag      840

gaggaaggtt cttttgaaat tttatacctg gagactttta aggtccttta cgatgctggc      900

ttctctattg acgatgaaca tattaaagca gagtatgttg catcttccgt tagagcagtt      960

tacgaaccca tcctcgcaag tcattttgga gaagctatta tacctgacat attccacagg     1020

tttgcgaagc atgcagcaaa ggttctcccc ttgggcaaag gcttctataa taatcttatc     1080

atttctctcg ccaaaaagcc agagaagtca gacatgtaa                            1119


<210>  20
<211>  372
<212>  PRT
<213>  Coffea canephora

<400>  20

Met Glu Leu Gln Glu Val Leu Arg Met Asn Gly Gly Glu Gly Asp Thr 
1               5                   10                  15      


Ser Tyr Ala Lys Asn Ser Ala Tyr Asn Gln Leu Val Leu Ala Lys Val 
            20                  25                  30          


Lys Pro Val Leu Glu Gln Cys Val Arg Glu Leu Leu Arg Ala Asn Leu 
        35                  40                  45              


Pro Asn Ile Asn Lys Cys Ile Lys Val Ala Asp Leu Gly Cys Ala Ser 
    50                  55                  60                  


Gly Pro Asn Thr Leu Leu Thr Val Arg Asp Ile Val Gln Ser Ile Asp 
65                  70                  75                  80  


Lys Val Gly Gln Glu Lys Lys Asn Glu Leu Glu Arg Pro Thr Ile Gln 
                85                  90                  95      


Ile Phe Leu Asn Asp Leu Phe Pro Asn Asp Phe Asn Ser Val Phe Lys 
            100                 105                 110         


Leu Leu Pro Ser Phe Tyr Arg Lys Leu Glu Lys Glu Asn Gly Arg Lys 
        115                 120                 125             


Ile Gly Ser Cys Leu Ile Gly Ala Met Pro Gly Ser Phe Tyr Ser Arg 
    130                 135                 140                 


Leu Phe Pro Glu Glu Ser Met His Phe Leu His Ser Cys Tyr Cys Leu 
145                 150                 155                 160 


Gln Trp Leu Ser Gln Val Pro Ser Gly Leu Val Thr Glu Leu Gly Ile 
                165                 170                 175     


Gly Thr Asn Lys Gly Ser Ile Tyr Ser Ser Lys Ala Ser Arg Leu Pro 
            180                 185                 190         


Val Gln Lys Ala Tyr Leu Asp Gln Phe Thr Lys Asp Phe Thr Thr Phe 
        195                 200                 205             


Leu Arg Ile His Ser Glu Glu Leu Phe Ser His Gly Arg Met Leu Leu 
    210                 215                 220                 


Thr Cys Ile Cys Lys Gly Val Glu Leu Asp Ala Arg Asn Ala Ile Asp 
225                 230                 235                 240 


Leu Leu Glu Met Ala Ile Asn Asp Leu Val Val Glu Gly His Leu Glu 
                245                 250                 255     


Glu Glu Lys Leu Asp Ser Phe Asn Leu Pro Val Tyr Ile Pro Ser Ala 
            260                 265                 270         


Glu Glu Val Lys Cys Ile Val Glu Glu Glu Gly Ser Phe Glu Ile Leu 
        275                 280                 285             


Tyr Leu Glu Thr Phe Lys Val Leu Tyr Asp Ala Gly Phe Ser Ile Asp 
    290                 295                 300                 


Asp Glu His Ile Lys Ala Glu Tyr Val Ala Ser Ser Val Arg Ala Val 
305                 310                 315                 320 


Tyr Glu Pro Ile Leu Ala Ser His Phe Gly Glu Ala Ile Ile Pro Asp 
                325                 330                 335     


Ile Phe His Arg Phe Ala Lys His Ala Ala Lys Val Leu Pro Leu Gly 
            340                 345                 350         


Lys Gly Phe Tyr Asn Asn Leu Ile Ile Ser Leu Ala Lys Lys Pro Glu 
        355                 360                 365             


Lys Ser Asp Met 
    370         


<210>  21
<211>  1137
<212>  DNA
<213>  Coffea arabica

<400>  21
atggagctcc aagaagtcct gcatatgaat gaaggtgaag gcgatacaag ctacgccaag       60

aatgcatcct acaatctggc tcttgccaag gtgaaacctt tccttgaaca atgcatacga      120

gaattgttgc gggccaactt gcccaacatc aacaagtgca ttaaagttgc ggatttggga      180

tgcgcttctg gaccaaacac acttttaaca gtgcgggaca ttgtgcaaag tattgacaaa      240

gttggccagg aagagaagaa tgaattagaa cgtcccacca ttcagatttt tctgaatgat      300

cttttccaaa atgatttcaa ttcggttttc aagttgctgc caagcttcta ccgcaaactc      360

gagaaagaaa atggacgcaa gataggatcg tgcctaataa gcgcaatgcc tggctctttc      420

tacggcagac tcttccccga ggagtccatg cattttttgc actcttgtta cagtgttcat      480

tggttatctc aggttcccag cggtttggtg attgaattgg ggattggtgc aaacaaaggg      540

agtatttact cttccaaagg atgtcgtccg cccgtccaga aggcatattt ggatcaattt      600

acgaaagatt ttaccacatt tctaaggatt cattcgaaag agttgttttc acgtggccga      660

atgctcctta cctgcatttg taaagtagat gaattcgacg aaccgaatcc cctagactta      720

cttgacatgg caataaacga cttgattgtt gagggacttc tggaggaaga aaaattggat      780

agtttcaata ttccattctt tacaccttca gcagaagaag taaagtgcat agttgaggag      840

gaaggttctt gcgaaatttt atatctggag acttttaagg cccattatga tgctgccttc      900

tctattgatg atgattaccc agtaagatcc catgaacaaa ttaaagcaga gtatgtggca      960

tcattaatta gatcagttta cgaacccatc ctcgcaagtc attttggaga agctattatg     1020

cctgacttat tccacaggct tgcgaagcat gcagcaaagg ttctccacat gggcaaaggc     1080

tgctataata atcttatcat ttctctcgcc aaaaagccag agaagtcaga cgtgtaa        1137


<210>  22
<211>  378
<212>  PRT
<213>  Coffea arabica

<400>  22

Met Glu Leu Gln Glu Val Leu His Met Asn Glu Gly Glu Gly Asp Thr 
1               5                   10                  15      


Ser Tyr Ala Lys Asn Ala Ser Tyr Asn Leu Ala Leu Ala Lys Val Lys 
            20                  25                  30          


Pro Phe Leu Glu Gln Cys Ile Arg Glu Leu Leu Arg Ala Asn Leu Pro 
        35                  40                  45              


Asn Ile Asn Lys Cys Ile Lys Val Ala Asp Leu Gly Cys Ala Ser Gly 
    50                  55                  60                  


Pro Asn Thr Leu Leu Thr Val Arg Asp Ile Val Gln Ser Ile Asp Lys 
65                  70                  75                  80  


Val Gly Gln Glu Glu Lys Asn Glu Leu Glu Arg Pro Thr Ile Gln Ile 
                85                  90                  95      


Phe Leu Asn Asp Leu Phe Gln Asn Asp Phe Asn Ser Val Phe Lys Leu 
            100                 105                 110         


Leu Pro Ser Phe Tyr Arg Lys Leu Glu Lys Glu Asn Gly Arg Lys Ile 
        115                 120                 125             


Gly Ser Cys Leu Ile Ser Ala Met Pro Gly Ser Phe Tyr Gly Arg Leu 
    130                 135                 140                 


Phe Pro Glu Glu Ser Met His Phe Leu His Ser Cys Tyr Ser Val His 
145                 150                 155                 160 


Trp Leu Ser Gln Val Pro Ser Gly Leu Val Ile Glu Leu Gly Ile Gly 
                165                 170                 175     


Ala Asn Lys Gly Ser Ile Tyr Ser Ser Lys Gly Cys Arg Pro Pro Val 
            180                 185                 190         


Gln Lys Ala Tyr Leu Asp Gln Phe Thr Lys Asp Phe Thr Thr Phe Leu 
        195                 200                 205             


Arg Ile His Ser Lys Glu Leu Phe Ser Arg Gly Arg Met Leu Leu Thr 
    210                 215                 220                 


Cys Ile Cys Lys Val Asp Glu Phe Asp Glu Pro Asn Pro Leu Asp Leu 
225                 230                 235                 240 


Leu Asp Met Ala Ile Asn Asp Leu Ile Val Glu Gly Leu Leu Glu Glu 
                245                 250                 255     


Glu Lys Leu Asp Ser Phe Asn Ile Pro Phe Phe Thr Pro Ser Ala Glu 
            260                 265                 270         


Glu Val Lys Cys Ile Val Glu Glu Glu Gly Ser Cys Glu Ile Leu Tyr 
        275                 280                 285             


Leu Glu Thr Phe Lys Ala His Tyr Asp Ala Ala Phe Ser Ile Asp Asp 
    290                 295                 300                 


Asp Tyr Pro Val Arg Ser His Glu Gln Ile Lys Ala Glu Tyr Val Ala 
305                 310                 315                 320 


Ser Leu Ile Arg Ser Val Tyr Glu Pro Ile Leu Ala Ser His Phe Gly 
                325                 330                 335     


Glu Ala Ile Met Pro Asp Leu Phe His Arg Leu Ala Lys His Ala Ala 
            340                 345                 350         


Lys Val Leu His Met Gly Lys Gly Cys Tyr Asn Asn Leu Ile Ile Ser 
        355                 360                 365             


Leu Ala Lys Lys Pro Glu Lys Ser Asp Val 
    370                 375             


<210>  23
<211>  1155
<212>  DNA
<213>  Coffea arabica

<400>  23
atggagctcc aagaagtcct gcatatgaat gaaggtgaag gcgatacaag ctacgccaag       60

aatgcatcct acaatctggc tcttgccaag gtgaaacctt tccttgaaca atgcatacga      120

gaattgttgc gggccaactt gcccaacatc aacaagtgca ttaaagttgc ggatttggga      180

tgcgcttctg gaccaaacac acttttaaca gtgcgggaca ttgtgcaaag tattgacaaa      240

gttggccagg aagagaagaa tgaattagaa cgtcccacca ttcagatttt tctgaatgat      300

cttttccaaa atgatttcaa ttcggttttc aagttgctgc caagcttcta ccgcaaactc      360

gagaaagaaa atggacgcaa gataggatcg tgcctaataa gcgcaatgcc tggctctttc      420

tacggcagac tcttccccga ggagtccatg cattttttgc actcttgtta cagtgttcat      480

tggttatctc aggttcccag cggtttggtg attgaattgg ggattggtgc aaacaaaggg      540

agtatttact cttccaaagc aagtcgtccg cccgtccaga aggcatattt ggatcaattt      600

acgaaagatt ttaccacatt tctaaggatt cattcgaaag agttgttttc acgtggccga      660

atgctcctta cttgcatttg taaagtagat gaatacgacg aaccgaatcc cctagactta      720

cttgacatgg caataaacga cttgattgtt gagggacatc tggaggaaga aaaattggct      780

agtttcaatc ttccattctt tacaccttca gcagaagaag taaagtgcat agttgaggag      840

gaaggttctt ttgaaatttt atacctggag acttttaagg cccattatga tgctggcttc      900

tctattgatg atgattaccc agtaagatcc catttccaag tatacggcga tgaacatatt      960

aaagcagagt atgtggcatc attaattaga tcagtttacg aacccatcct cgcaagtcat     1020

tttggagaag ctattatgcc tgacttattc cacaggcttg cgaagcatgc agcaaaggtt     1080

ctccacttgg gcaaaggctg ctataataat cttatcattt ctctcgccaa aaagccagag     1140

aagtcagacg tgtaa                                                      1155


<210>  24
<211>  384
<212>  PRT
<213>  Coffea arabica

<400>  24

Met Glu Leu Gln Glu Val Leu His Met Asn Glu Gly Glu Gly Asp Thr 
1               5                   10                  15      


Ser Tyr Ala Lys Asn Ala Ser Tyr Asn Leu Ala Leu Ala Lys Val Lys 
            20                  25                  30          


Pro Phe Leu Glu Gln Cys Ile Arg Glu Leu Leu Arg Ala Asn Leu Pro 
        35                  40                  45              


Asn Ile Asn Lys Cys Ile Lys Val Ala Asp Leu Gly Cys Ala Ser Gly 
    50                  55                  60                  


Pro Asn Thr Leu Leu Thr Val Arg Asp Ile Val Gln Ser Ile Asp Lys 
65                  70                  75                  80  


Val Gly Gln Glu Glu Lys Asn Glu Leu Glu Arg Pro Thr Ile Gln Ile 
                85                  90                  95      


Phe Leu Asn Asp Leu Phe Gln Asn Asp Phe Asn Ser Val Phe Lys Leu 
            100                 105                 110         


Leu Pro Ser Phe Tyr Arg Lys Leu Glu Lys Glu Asn Gly Arg Lys Ile 
        115                 120                 125             


Gly Ser Cys Leu Ile Ser Ala Met Pro Gly Ser Phe Tyr Gly Arg Leu 
    130                 135                 140                 


Phe Pro Glu Glu Ser Met His Phe Leu His Ser Cys Tyr Ser Val His 
145                 150                 155                 160 


Trp Leu Ser Gln Val Pro Ser Gly Leu Val Ile Glu Leu Gly Ile Gly 
                165                 170                 175     


Ala Asn Lys Gly Ser Ile Tyr Ser Ser Lys Ala Ser Arg Pro Pro Val 
            180                 185                 190         


Gln Lys Ala Tyr Leu Asp Gln Phe Thr Lys Asp Phe Thr Thr Phe Leu 
        195                 200                 205             


Arg Ile His Ser Lys Glu Leu Phe Ser Arg Gly Arg Met Leu Leu Thr 
    210                 215                 220                 


Cys Ile Cys Lys Val Asp Glu Tyr Asp Glu Pro Asn Pro Leu Asp Leu 
225                 230                 235                 240 


Leu Asp Met Ala Ile Asn Asp Leu Ile Val Glu Gly His Leu Glu Glu 
                245                 250                 255     


Glu Lys Leu Ala Ser Phe Asn Leu Pro Phe Phe Thr Pro Ser Ala Glu 
            260                 265                 270         


Glu Val Lys Cys Ile Val Glu Glu Glu Gly Ser Phe Glu Ile Leu Tyr 
        275                 280                 285             


Leu Glu Thr Phe Lys Ala His Tyr Asp Ala Gly Phe Ser Ile Asp Asp 
    290                 295                 300                 


Asp Tyr Pro Val Arg Ser His Phe Gln Val Tyr Gly Asp Glu His Ile 
305                 310                 315                 320 


Lys Ala Glu Tyr Val Ala Ser Leu Ile Arg Ser Val Tyr Glu Pro Ile 
                325                 330                 335     


Leu Ala Ser His Phe Gly Glu Ala Ile Met Pro Asp Leu Phe His Arg 
            340                 345                 350         


Leu Ala Lys His Ala Ala Lys Val Leu His Leu Gly Lys Gly Cys Tyr 
        355                 360                 365             


Asn Asn Leu Ile Ile Ser Leu Ala Lys Lys Pro Glu Lys Ser Asp Val 
    370                 375                 380                 


<210>  25
<211>  1024
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT Cc09_g06970 - partial nucleic acid sequence

<400>  25
atggagctcc aagaagtcct gcggatgaat ggaggcgaag gcgatacaag ctacgccaag       60

aattcagcct acaatgtctg tctgtctctc tatctctctt taacacacac acacacagag      120

tagtagtaaa tcatgctatg atacgtcgat ctctaactta gtatgtcttt tttcccccct      180

taacatttgt attttggagt ggtatgtgta gcaactggtt ctcgccaagg tgaaacctgt      240

ccttgaacaa tgcgtacggg aattgttgcg ggccaacttg cccaacatca acaagtgcat      300

taaagttgcg gatttgggat gcgcttctgg accaaacaca cttttaacag ttcgggacat      360

tgtccaaagt attgacaaag ttggccagga aaagaagaat gaattagaac gtcccaccat      420

tcagattttt ctgaatgatc ttttcccaaa tgatttcaat tcggttttca agttgctgcc      480

aagcttctac cgcaaacttg agaaagaaaa tggacgcaaa ataggatcgt gcctaatagg      540

ggcaatgccc ggctctttct acagcagact cttccccgag gagtccatgc attttttaca      600

ctcttgttac tgtcttcaat ggttatctca ggtctttgag ttaatccctt ttatcttttt      660

aatttttctt gtagcaaaaa tagttcatga ttttcattca acacattagt aactatgcac      720

ggaaatttct ttaataattc tcaagatatc cacaggaatc caagaaagag atttctgaag      780

aaactaataa catattttat tcaagtcgtg gctcatgatt tatattccca catgcaacac      840

taacaaaatg atccaactat ataagttacc agctctggac gtgcaggttc ctagcggttt      900

ggtgactgaa tcggggatca gtacgaacaa agggagcatt tactcttcca aagcaagtcg      960

tctgcccgtc cagaaggcat atttggatca atttacgaaa gattttacca catttctaag     1020

gatt                                                                  1024


<210>  26
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT Cc09_g06970 target sequence

<400>  26
ccaaggtgaa acctgtcctt gaa                                               23


<210>  27
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT Cc09_g06970 target sequence

<400>  27
caagtgcatt aaagttgcgg                                                   20


<210>  28
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT Cc09_g06970 target sequence

<400>  28
ccaaatgatt tcaattcggt ttt                                               23


<210>  29
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT Cc09_g06970 target sequence

<400>  29
aaagaaaatg gacgcaaaat agg                                               23


<210>  30
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT Cc09_g06970 target sequence

<400>  30
tgcctaatag gggcaatgcc cgg                                               23


<210>  31
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT Cc09_g06970 target sequence

<400>  31
cccgaggagt ccatgcattt ttt                                               23


<210>  32
<211>  1400
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MXMT Cc09_g06960 - partial nucleic acid sequence

<400>  32
tcattcgtgt ctggttccca ttggctgtgc gctttctttc tgacccattg acagactttt       60

ctacgcacgt aactagctgg ttagcatacg catctatgaa attttcgcta tttaagcccg      120

aaattttgca caattaatca ttaacagaca ccttctttag ccgtcgcaat tcgattgtcc      180

tgtatatgaa tggagctcca agaagtcctg catatgaatg gaggcgaagg cgatacaagc      240

tacgccaaga attcatcgta caatgtctgt ctgtctatct ctctctttaa cacacacaca      300

cacacagagt agtagtaaat tatgctatga tacgttgatc tctgacttag tatgtctttt      360

ttcgcccctt aacatttgta ttttggagtg gtatgtgtag caactggttc tcaccaaggt      420

gaaacctgtc cttgaacaat gcatacgaga attgttgcgg gccaacttgc ccaacatcaa      480

caagtgcatt aaagttgcgg atttgggatg cgcttctgga ccaaacacac ttttaacagt      540

tcgggacatt gtgcaaagta ttgacaaagt tggccaggaa gagaagaatg aattagaaca      600

tcccaccatt caaatttttc tgaatgatct tttccaaaat gatttcaatt cagttttcaa      660

gttgctgcca agcttctacc gcaaactcga gaaagaaaat ggacgcaaaa taggatcgtg      720

cctaataagc gcaatgcctg gctctttcta cggcagactc ttccccgagg agtccatgca      780

ttttttgcac tcttgttaca gtgttcattg gttatctcag gtctttgagt taatcccttt      840

tatcttttta ctttttcttg tagcaaaaat agttcatgat tttcattcaa cacattagta      900

actatgcatg gaaatttctt taataattct aaagacatcc acaggaatcc aagaaagaga      960

tttctgaaga aactaataac atattttatt taagtcgtgg ctcatgattt atattcccac     1020

atgcaacact aacaaaatga tccaactata taagttacca gttctagacg tgcaggttcc     1080

cagcggattg gtgactgaac tggggatcag tgcgaacaaa gggatcattt actcttccaa     1140

agcaagtcct ccgcccgtcc agaaggcata tttggaccaa tttacaaaag attttaccac     1200

atttctgagg attcattcgg aagagttgct ttcaggtggc cgaatgctcc ttacttgcat     1260

ttgtaaagga gatgaatccg atggcctgaa taccatagac ttacttgaga gagcaataaa     1320

cgacttggtt gttgaggtta tcatttctct gtctctttga taatcagatg ctcattgctt     1380

gttatctgaa ataaactaga                                                 1400


<210>  33
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MXMT Cc09_g06960 target sequence

<400>  33
ccaaggtgaa acctgtcctt gaa                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MXMT Cc09_g06960 target sequence

<400>  34
caacaagtgc attaaagttg cgg                                               23


<210>  35
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MXMT Cc09_g06960 target sequence

<400>  35
aaagaaaatg gacgcaaaat agg                                               23


<210>  36
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MXMT Cc09_g06960 target sequence

<400>  36
cccgaggagt ccatgcattt ttt                                               23


<210>  37
<211>  1105
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MXMT Cc00_g24720 - partial nucleic acid sequence

<400>  37
gtgcgctttc tttctgacga attgacagac ttttctacgc acggaggtag ctggctagca       60

tacgcatcta tgaaattttc gctacttaag cccgaaattt tgcacaatta atcattaaca      120

gacaccttct ttagcagtcg caattcgatt gtcctgcata tgaatggagc tccaagaagt      180

cctgcatatg aatgaaggtg aaggcgatac aagctacgcc aagaatgcat cctacaatgt      240

ctgtctgtct ctctatctct ctttaacaca cacacacaca gagaatagtg gtaaatcatg      300

ctatgatacg tcgatctcta acttcacatt tgtattttgg actggtatgt gtaacagctg      360

gctcttgcca aggtgaaacc tttccttgaa caatgcatac gagaattgtt gcgggccaac      420

ttgcccaaca tcaacaagtg cattaaagtt gcggatttgg gatgcgcttc tggaccaaac      480

acacttttaa cagtgcggga cattgtgcaa agtattgaca aagttggcca ggaagagaag      540

aatgaattag aacgtcccac cattcagatt tttctgaatg atcttttcca aaatgatttc      600

aattcggttt tcaagttgct gccaagcttc taccgcaaac tcgagaaaga aaatggacgc      660

aagataggat cgtgcctaat aagcgcaatg cctggctctt tctacggcag actcttcccc      720

gaggagtcca tgcatttttt gcactcttgt tacagtgttc attggttatc tcaggtcttt      780

gagttaatcc cttttatctt tttacttttt cttgtagcaa aaatggttcg tgattttcat      840

tcaacacatt agtaactatg catggaaatt tctttaataa ttctaaagat atccacagga      900

atccaagaaa gagatttctg aagaaactaa taacatattt tatctaagtc gtggctcatg      960

atttacattc ccacatgcaa cactaacaaa atgatccaac tatataagtt accagttctg     1020

gacgtgcagg ttcccagcgg tttggtgatt gaattgggga ttggtgcaaa caaagggagt     1080

atttactctt ccaaaggatg tcgtc                                           1105


<210>  38
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MXMT Cc00_g24720 target sequence

<400>  38
cctttccttg aacaatgcat acg                                               23


<210>  39
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MXMT Cc00_g24720 target sequence

<400>  39
caacaagtgc attaaagttg cgg                                               23


<210>  40
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MXMT Cc00_g24720 target sequence

<400>  40
aaagaaaatg gacgcaagat agg                                               23


<210>  41
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MXMT Cc00_g24720 target sequence

<400>  41
cccgaggagt ccatgcattt ttt                                               23


<210>  42
<211>  1315
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DXMT Cc09_g06950 - partial nucleic acid sequence

<400>  42
tttatcccaa ttgtgtgtgg ttcccattgg ctgtgctctt tctctctgac caattgacag       60

atttttctac gcacgtagtt agccggttag catacgcatc taagaaattt tcgccattta      120

agtccgaaat ttcgcacagt taatcattaa cagacacctt ccttagcagt cccaattcga      180

tttatgtaca agtcctgcat atgaatggag ctccaagaag tcctgcatat gaatggaggc      240

gaaggcgaag caagctacgc caagaattca tccttcaatg tctgtctatc tgtctatctc      300

tctctttaac acacacacac acacacacag agtagtagta aatcatgcta tgatacgtcg      360

atctctaact tagtatgtct tttttcgccc cttaacattt gtattttgga gtggtatgtg      420

tagcaactgg ttctcgccaa ggtgaaacct gtccttgaac aatgcgtacg ggaattgttg      480

cgggccaact tgcccaacat caacaagtgc attaaagttg cagatttggg atgcgcttcc      540

ggaccaaaca cacttttaac cgttcgggac actgtacaaa gtattgacaa agttaggcaa      600

gaaatgaaga atgaattaga acgtcccacc attcaggttt ttctgactga tcttttccaa      660

aatgatttca attcggtttt catgctgctg ccaagcttct accgcaaact tgagaaagaa      720

aatggacgca aaataggatc gtgcctaata gccgcaatgc ctggctcttt ccacggcaga      780

ctcttccccg aggagtccat gcatttttta cactcttctt acagtcttca gtttttatcc      840

caggtctttg aattactccc ttttatcttt ttactttttc ttgtagcaaa aatagttcat      900

gattttcatt caacacatta gttactatgc atggaaattt ctttaataat tctcaagata      960

tccacaggaa tccaagaaag agatttctaa agggaaccag ctttagactg caggttccca     1020

gcggtttggt gactgaattg gggatcactg cgaacaaaag gagcatttac tcttccaaag     1080

caagtcctcc gcccgtccag aaggcatatt tggatcaatt tacgaaagat tttaccacat     1140

ttttaaggat gcgttcggaa gagttgcttt cacgtggccg aatgctcctt acttgcattt     1200

gtaaaggaga tgaatgcgac ggcccgaata ccatggactt acttgagatg gcaataaacg     1260

acttggttgt tgaggttaat catttctctg tctctttgat gatcagatgc tcatt          1315


<210>  43
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DXMT Cc09_g06950 target sequence

<400>  43
ccaaggtgaa acctgtcctt gaa                                               23


<210>  44
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DXMT Cc09_g06950 target sequence

<400>  44
aaagaaaatg gacgcaaaat agg                                               23


<210>  45
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DXMT Cc09_g06950 target sequence

<400>  45
cccgaggagt ccatgcattt ttt                                               23


<210>  46
<211>  1270
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DXMT Cc01_g00720 - partial nucleic acid sequence

<400>  46
aaaacaaacg aaagtgactt cattatctct aacctccgat ttttatcatt agtggcttgt       60

tcccattggc tgtgcgcttc ctttctgact aattgataga ctttctacgc acgtaggtag      120

gcagctagca tacgcatcta tgaaattttc gctatttaag cccgaaattt cgcacaatta      180

atcattaaca gataccttct ttagcagtcc caattcgatt tatgcacaag tcctgcgtat      240

gaatggagct ccaagaagtc ctgcatatga atggaggcga aggcgataca agctacgcca      300

agaactcatc ctacaatgtc tgtctgtctc tctatctctc tctttaacac acacacacac      360

acacacagag tagtagtaaa tcatgctatg atacgtcgat ctctaactta gtatgtcttt      420

tttccccctt aacatttgta ttttggagtg gtatgtgttg cagctgtttc tcatcagggt      480

gaaacctgtc cttgaacaat gcatacaaga attgttgcgg gccaacttgc ccaacatcaa      540

caagtgcttt aaagttgggg atttgggatg cgcttctgga ccaaacacat tttcaacagt      600

tcgggacatt gtacaaagta ttgacaaagt tggccaggaa aagaagaatg aattagaacg      660

tcccaccatt cagatttttc tgaatgatct tttccaaaat gatttcaatt cggttttcaa      720

gttgctgcca agcttctacc gcaatcttga gaaagaaaat ggacgcaaaa taggatcgtg      780

cctgataggc gcaatgcccg gctctttcta cagcagactc ttccccgagg agtccatgca      840

ttttttacac tcttgttact gtttgcattg gttatctcag gtctttgagt taatcccttc      900

tatcttgttt actttttctt gtagcaaaaa taagttcacg atttttattc aacacattag      960

taactatgca tggaaatttc tttaataatt ctcaagatat ccacaggaat ccaagaaaga     1020

gatttctgac gaaactaata acacatttta tttaattcgt ggctcatgat ttatattccc     1080

acatgcaaca ctaacaaaat gatccaacta tataagttac cagctctaga cgtgcaggtt     1140

cccagcggtt tggtgactga attggggatc agtgtgaaca aagggtgcat ttactcttcc     1200

aaagcaagtc gtccgcccat ccagaaggca tatttggatc aatttacgaa agattttacc     1260

acatttctga                                                            1270


<210>  47
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DXMT Cc01_g00720 target sequence

<400>  47
aaagaaaatg gacgcaaaat agg                                               23


<210>  48
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DXMT Cc01_g00720 target sequence

<400>  48
cccgaggagt ccatgcattt ttt                                               23


<210>  49
<211>  1319
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DXMT Cc02_g09350 - partial nucleic acid sequence

<400>  49
gagtatgtaa atatgtgatt gaaaaaaagt actcagatta tgtttaacaa atttgccaaa       60

aaaggcaata catgctgatt atattcgaac attccacttt tttggaccgg aaagagaagg      120

gatatgggca tttattgagg atcgtttgga ggatgagcag taatggcatc tctgaaagct      180

gtccaatact gacacttgga ttgattattt gttgaagatg atgattgatg atgatgatga      240

tgataccgat acttggacac ttggattgat gatgatgagg aaaggataaa tactcctata      300

caagattgtc gaaaattcga ttaagtaaga gatcagaaat ggaactccaa cgagtcctgc      360

acatgagtgg aggcgaaggc gatacaagct acgccaaaaa ttcatcctac caagtctgtc      420

tatccctctt tgacaaacac acacgcacgc gcccgcagtc acaggagtgg taacacaaga      480

ctgtgatacg ttgatctcta acatagcgta cccttttttt ggctttaact tttttttttt      540

tttttttgag tggtgtatgt agaagttggt actgacctag gtgaagcctg tacttgaaca      600

atgcatacaa gaattgttgc ggaccaactt accctacgac gagaagtgca ttagagttgc      660

tgatttggga tgctcttcag gaccaaacac actattaaca gtttcggaca tcatacaaag      720

tattgacaaa gttagccagg aaatggacaa tgaatttgca ctgcccacga ttcaggtttt      780

tctgaatgat cttttcgaaa atgatttcaa tacggttatc aagtcgctgc caagcttcta      840

ccgcaaactt gaaaaagaaa atggacgcaa aataggatcg tgcctgatag cagcaatgcc      900

tggctctttc tacggcagac tcttccccga gcagtccgtc cattttttac actcttctta      960

cagtctccat tggttatctc aggtttttga atcaatccct ctaatcattt tccattttct     1020

tgcagcaaag atagttcatg catgattttc attcaacaca ttagtaacta tgcatggaag     1080

gcttctttaa caattctcaa gacatcccca agaacccaac ccaagaaaag atttctcaag     1140

aaatcaacaa cctttttttt cttttttttt tggtgtggtc gcggctcatg atttgtagta     1200

ttcccacatg caattgaccc taacaaaatg ctccaacaat gtaacaagtt accagcttga     1260

gacgcgtcac gttgacaggt tcccaatggt ttggtgactg aatcggggat cagtgcgaa      1319


<210>  50
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DXMT Cc02_g09350 target sequence

<400>  50
aaagaaaatg gacgcaaaat agg                                               23


<210>  51
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  51
aaaaccgaat tgaaatcatt                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  52
tgcctaatag gggcaatgcc                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  53
ttcaaggaca ggtttcacct                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  54
caacaagtgc attaaagttg                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  55
aaagaaaatg gacgcaaaat                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  56
aaaaaatgca tggactcctc                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  57
cgtatgcatt gttcaaggaa                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  58
aaagaaaatg gacgcaagat                                                   20


<210>  59
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  59
tttgcacaat taatcattaa ggg                                               23


<210>  60
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  60
caagaagtcc tgcggatgaa tgg                                               23


<210>  61
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  61
acttgtacat aaatcaaatt ggg                                               23


<210>  62
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  62
caaattggga ctgccaaaga agg                                               23


<210>  63
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  63
gaagtcctgc atatgaatga agg                                               23


<210>  64
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  64
gacgggcgga cgacatcctt tgg                                               23


<210>  65
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  65
ttggtgattg aattggggat tgg                                               23


<210>  66
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  66
gggagtattt actcttccaa agg                                               23


<210>  67
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  67
tcaacaagtg ctttaaagtt ggg                                               23


<210>  68
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  68
tgctttaaag ttggggattt ggg                                               23


<210>  69
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  69
aaaataggat cgtgcctgat agg                                               23


<210>  70
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  70
cgaactgttg aaaatgtgtt tgg                                               23


<210>  71
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  71
cctcggggaa gagtctgccg tgg                                               23


<210>  72
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  72
actttgtaca gtgtcccgaa cgg                                               23


<210>  73
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  73
attagaacgt cccaccattc agg                                               23


<210>  74
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  74
atgcgacggc ccgaatacca tgg                                               23


<210>  75
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  75
cattcggaag agttgctttc agg                                               23


<210>  76
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  76
gtctatggta ttcaggccat cgg                                               23


<210>  77
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  77
agcggattgg tgactgaact ggg                                               23


<210>  78
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  78
tcggaagagt tgctttcagg tgg                                               23


<210>  79
<211>  1399
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT/MXMT/DXMT mutant seq 2023-3

<400>  79
tcattcgtgt ctggttccca ttggctgtgc gctttctttc tgacccattg acagactttt       60

ctacgcacgt aactagctgg ttagcatacg catctatgaa attttcgcta tttaagcccg      120

aaattttgca caattaatca ttaacagaca ccttctttag ccgtcgcaat tcgattgtcc      180

tgtatatgaa tggagctcca agaagtcctg catatgaatg gaggcgaagg cgatacaagc      240

tacgccaaga attcatcgta caatgtctgt ctgtctatct ctctctttaa cacacacaca      300

cacacagagt agtagtaaat tatgctatga tacgttgatc tctgacttag tatgtctttt      360

ttcgcccctt aacatttgta ttttggagtg gtatgtgtag caactggttc tcaccaaggg      420

aaacctgtcc ttgaacaatg catacgagaa ttgttgcggg ccaacttgcc caacatcaac      480

aagtgcatta aagttgcgga tttgggatgc gcttctggac caaacacact tttaacagtt      540

cgggacattg tgcaaagtat tgacaaagtt ggccaggaag agaagaatga attagaacat      600

cccaccattc aaatttttct gaatgatctt ttccaaaatg atttcaattc agttttcaag      660

ttgctgccaa gcttctaccg caaactcgag aaagaaaatg gacgcaaaat aggatcgtgc      720

ctaataagcg caatgcctgg ctctttctac ggcagactct tccccgagga gtccatgcat      780

tttttgcact cttgttacag tgttcattgg ttatctcagg tctttgagtt aatccctttt      840

atctttttac tttttcttgt agcaaaaata gttcatgatt ttcattcaac acattagtaa      900

ctatgcatgg aaatttcttt aataattcta aagacatcca caggaatcca agaaagagat      960

ttctgaagaa actaataaca tattttattt aagtcgtggc tcatgattta tattcccaca     1020

tgcaacacta acaaaatgat ccaactatat aagttaccag ttctagacgt gcaggttccc     1080

agcggattgg tgactgaact ggggatcagt gcgaacaaag ggatcattta ctcttccaaa     1140

gcaagtcctc cgcccgtcca gaaggcatat ttggaccaat ttacaaaaga ttttaccaca     1200

tttctgagga ttcattcgga agagttgctt tcaggtggcc gaatgctcct tacttgcatt     1260

tgtaaaggag atgaatccga tggcctgaat accatagact tacttgagag agcaataaac     1320

gacttggttg ttgaggttat catttctctg tctctttgat aatcagatgc tcattgcttg     1380

ttatctgaaa taaactaga                                                  1399


<210>  80
<211>  1399
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT/MXMT/DXMT mutant seq 2023-6

<400>  80
tcattcgtgt ctggttccca ttggctgtgc gctttctttc tgacccattg acagactttt       60

ctacgcacgt aactagctgg ttagcatacg catctatgaa attttcgcta tttaagcccg      120

aaattttgca caattaatca ttaacagaca ccttctttag ccgtcgcaat tcgattgtcc      180

tgtatatgaa tggagctcca agaagtcctg catatgaatg gaggcgaagg cgatacaagc      240

tacgccaaga attcatcgta caatgtctgt ctgtctatct ctctctttaa cacacacaca      300

cacacagagt agtagtaaat tatgctatga tacgttgatc tctgacttag tatgtctttt      360

ttcgcccctt aacatttgta ttttggagtg gtatgtgtag caactggttc tcaccaaggg      420

aaacctgtcc ttgaacaatg catacgagaa ttgttgcggg ccaacttgcc caacatcaac      480

aagtgcatta aagttgcgga tttgggatgc gcttctggac caaacacact tttaacagtt      540

cgggacattg tgcaaagtat tgacaaagtt ggccaggaag agaagaatga attagaacat      600

cccaccattc aaatttttct gaatgatctt ttccaaaatg atttcaattc agttttcaag      660

ttgctgccaa gcttctaccg caaactcgag aaagaaaatg gacgcaaaat aggatcgtgc      720

ctaataagcg caatgcctgg ctctttctac ggcagactct tccccgagga gtccatgcat      780

tttttgcact cttgttacag tgttcattgg ttatctcagg tctttgagtt aatccctttt      840

atctttttac tttttcttgt agcaaaaata gttcatgatt ttcattcaac acattagtaa      900

ctatgcatgg aaatttcttt aataattcta aagacatcca caggaatcca agaaagagat      960

ttctgaagaa actaataaca tattttattt aagtcgtggc tcatgattta tattcccaca     1020

tgcaacacta acaaaatgat ccaactatat aagttaccag ttctagacgt gcaggttccc     1080

agcggattgg tgactgaact ggggatcagt gcgaacaaag ggatcattta ctcttccaaa     1140

gcaagtcctc cgcccgtcca gaaggcatat ttggaccaat ttacaaaaga ttttaccaca     1200

tttctgagga ttcattcgga agagttgctt tcaggtggcc gaatgctcct tacttgcatt     1260

tgtaaaggag atgaatccga tggcctgaat accatagact tacttgagag agcaataaac     1320

gacttggttg ttgaggttat catttctctg tctctttgat aatcagatgc tcattgcttg     1380

ttatctgaaa taaactaga                                                  1399


<210>  81
<211>  1022
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT mutant seq 2023-2

<400>  81
atggagctcc aagaagtcct gcggatgaat ggaggcgaag gcgatacaag ctacgccaag       60

aattcagcct acaatgtctg tctgtctctc tatctctctt taacacacac acacagagta      120

gtagtaaatc atgctatgat acgtcgatct ctaacttagt atgtcttttt tcccccctta      180

acatttgtat tttggagtgg tatgtgtagc aactggttct cgccaaggtg aaacctgtcc      240

ttgaacaatg cgtacgggaa ttgttgcggg ccaacttgcc caacatcaac aagtgcatta      300

aagttgcgga tttgggatgc gcttctggac caaacacact tttaacagtt cgggacattg      360

tccaaagtat tgacaaagtt ggccaggaaa agaagaatga attagaacgt cccaccattc      420

agatttttct gaatgatctt ttcccaaatg atttcaattc ggttttcaag ttgctgccaa      480

gcttctaccg caaacttgag aaagaaaatg gacgcaaaat aggatcgtgc ctaatagggg      540

caatgcccgg ctctttctac agcagactct tccccgagga gtccatgcat tttttacact      600

cttgttactg tcttcaatgg ttatctcagg tctttgagtt aatccctttt atctttttaa      660

tttttcttgt agcaaaaata gttcatgatt ttcattcaac acattagtaa ctatgcacgg      720

aaatttcttt aataattctc aagatatcca caggaatcca agaaagagat ttctgaagaa      780

actaataaca tattttattc aagtcgtggc tcatgattta tattcccaca tgcaacacta      840

acaaaatgat ccaactatat aagttaccag ctctggacgt gcaggttcct agcggtttgg      900

tgactgaatc ggggatcagt acgaacaaag ggagcattta ctcttccaaa gcaagtcgtc      960

tgcccgtcca gaaggcatat ttggatcaat ttacgaaaga ttttaccaca tttctaagga     1020

tt                                                                    1022


<210>  82
<211>  1025
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT mutant seq 2023-3

<400>  82
atggagctcc aagaagtcct gcggatgaat ggaggcgaag gcgatacaag ctacgccaag       60

aattcagcct acaatgtctg tctgtctctc tatctctctt taacacacac acacacagag      120

tagtagtaaa tcatgctatg atacgtcgat ctctaactta gtatgtcttt tttcccccct      180

taacatttgt attttggagt ggtatgtgta gcaactggtt ctcgccaagg atgaaacctg      240

tccttgaaca atgcgtacgg gaattgttgc gggccaactt gcccaacatc aacaagtgca      300

ttaaagttgc ggatttggga tgcgcttctg gaccaaacac acttttaaca gttcgggaca      360

ttgtccaaag tattgacaaa gttggccagg aaaagaagaa tgaattagaa cgtcccacca      420

ttcagatttt tctgaatgat cttttcccaa atgatttcaa ttcggttttc aagttgctgc      480

caagcttcta ccgcaaactt gagaaagaaa atggacgcaa aataggatcg tgcctaatag      540

gggcaatgcc cggctctttc tacagcagac tcttccccga ggagtccatg cattttttac      600

actcttgtta ctgtcttcaa tggttatctc aggtctttga gttaatccct tttatctttt      660

taatttttct tgtagcaaaa atagttcatg attttcattc aacacattag taactatgca      720

cggaaatttc tttaataatt ctcaagatat ccacaggaat ccaagaaaga gatttctgaa      780

gaaactaata acatatttta ttcaagtcgt ggctcatgat ttatattccc acatgcaaca      840

ctaacaaaat gatccaacta tataagttac cagctctgga cgtgcaggtt cctagcggtt      900

tggtgactga atcggggatc agtacgaaca aagggagcat ttactcttcc aaagcaagtc      960

gtctgcccgt ccagaaggca tatttggatc aatttacgaa agattttacc acatttctaa     1020

ggatt                                                                 1025


<210>  83
<211>  1025
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT mutant seq 2023-4

<400>  83
atggagctcc aagaagtcct gcggatgaat ggaggcgaag gcgatacaag ctacgccaag       60

aattcagcct acaatgtctg tctgtctctc tatctctctt taacacacac acacacagag      120

tagtagtaaa tcatgctatg atacgtcgat ctctaactta gtatgtcttt tttcccccct      180

taacatttgt attttggagt ggtatgtgta gcaactggtt ctcgccaagg atgaaacctg      240

tccttgaaca atgcgtacgg gaattgttgc gggccaactt gcccaacatc aacaagtgca      300

ttaaagttgc ggatttggga tgcgcttctg gaccaaacac acttttaaca gttcgggaca      360

ttgtccaaag tattgacaaa gttggccagg aaaagaagaa tgaattagaa cgtcccacca      420

ttcagatttt tctgaatgat cttttcccaa atgatttcaa ttcggttttc aagttgctgc      480

caagcttcta ccgcaaactt gagaaagaaa atggacgcaa aataggatcg tgcctaatag      540

gggcaatgcc cggctctttc tacagcagac tcttccccga ggagtccatg cattttttac      600

actcttgtta ctgtcttcaa tggttatctc aggtctttga gttaatccct tttatctttt      660

taatttttct tgtagcaaaa atagttcatg attttcattc aacacattag taactatgca      720

cggaaatttc tttaataatt ctcaagatat ccacaggaat ccaagaaaga gatttctgaa      780

gaaactaata acatatttta ttcaagtcgt ggctcatgat ttatattccc acatgcaaca      840

ctaacaaaat gatccaacta tataagttac cagctctgga cgtgcaggtt cctagcggtt      900

tggtgactga atcggggatc agtacgaaca aagggagcat ttactcttcc aaagcaagtc      960

gtctgcccgt ccagaaggca tatttggatc aatttacgaa agattttacc acatttctaa     1020

ggatt                                                                 1025


<210>  84
<211>  1022
<212>  DNA
<213>  Artificial sequence

<220>
<223>  XMT mutant seq 2023-6

<400>  84
atggagctcc aagaagtcct gcggatgaat ggaggcgaag gcgatacaag ctacgccaag       60

aattcagcct acaatgtctg tctgtctctc tatctctctt taacacacac acacagagta      120

gtagtaaatc atgctatgat acgtcgatct ctaacttagt atgtcttttt tcccccctta      180

acatttgtat tttggagtgg tatgtgtagc aactggttct cgccaaggtg aaacctgtcc      240

ttgaacaatg cgtacgggaa ttgttgcggg ccaacttgcc caacatcaac aagtgcatta      300

aagttgcgga tttgggatgc gcttctggac caaacacact tttaacagtt cgggacattg      360

tccaaagtat tgacaaagtt ggccaggaaa agaagaatga attagaacgt cccaccattc      420

agatttttct gaatgatctt ttcccaaatg atttcaattc ggttttcaag ttgctgccaa      480

gcttctaccg caaacttgag aaagaaaatg gacgcaaaat aggatcgtgc ctaatagggg      540

caatgcccgg ctctttctac agcagactct tccccgagga gtccatgcat tttttacact      600

cttgttactg tcttcaatgg ttatctcagg tctttgagtt aatccctttt atctttttaa      660

tttttcttgt agcaaaaata gttcatgatt ttcattcaac acattagtaa ctatgcacgg      720

aaatttcttt aataattctc aagatatcca caggaatcca agaaagagat ttctgaagaa      780

actaataaca tattttattc aagtcgtggc tcatgattta tattcccaca tgcaacacta      840

acaaaatgat ccaactatat aagttaccag ctctggacgt gcaggttcct agcggtttgg      900

tgactgaatc ggggatcagt acgaacaaag ggagcattta ctcttccaaa gcaagtcgtc      960

tgcccgtcca gaaggcatat ttggatcaat ttacgaaaga ttttaccaca tttctaagga     1020

tt                                                                    1022


<210>  85
<211>  894
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cc09_g06950_2025 nucleic acid sequence

<400>  85
ccattggctg tgctctttct ctctgaccaa ttgacagatt tttctacgca cgtagttagc       60

cggttagcat acgcatctaa gaaattttcg ccatttaagt ccgaaatttc gcacagttaa      120

tcattaacag acaccttcct tagcagtccc aattcgattt atgtacaagt cctgcatatg      180

aatggagctc caagaagtcc tgcatatgaa tggaggcgaa ggcgaagcaa gctacgccaa      240

gaattcatcc ttcaatgtct gtctatctgt ctatctctct ctttaacaca cacacacaca      300

cacacagagt agtagtaaat catgctatga tacgtcgatc tctaacttag tatgtctttt      360

ttcgcccctt aacatttgta ttttggagtg gtatgtgtag caactggttc tcgccaagga      420

ataggatcgt gcctaatagc cgcaatgcct ggctctttcc acggcagact cttccccgag      480

gagtccatgc attttttaca ctcttcttac agtcttcagt ttttatccca ggtctttgaa      540

ttactccctt ttatcttttt actttttctt gtagcaaaaa tagttcatga ttttcattca      600

acacattagt tactatgcat ggaaatttct ttaataattc tcaagatatc cacaggaatc      660

caagaaagag atttctaaag ggaaccagct ttagactgca ggttcccagc ggtttggtga      720

ctgaattggg gatcactgcg aacaaaagga gcatttactc ttccaaagca agtcctccgc      780

ccgtccagaa ggcatatttg gatcaattta cgaaagattt taccacattt ttaaggatgc      840

gttcggaaga gttgctttca cgtggccgaa tgctccttac ttgcatttgt aaag            894


<210>  86
<211>  622
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cc09_g06970_2025 nucleic acid sequence

<400>  86
atggagctcc aagaagtcct gcggatgaat ggaggcgaag gcgatacaag ctacgccaag       60

aattcagcct acaatgtctg tctgtctctc tatctctctt taacacacac acacacacac      120

acacacacac acagagtagt agtaaatcat gctatgatac gtcgatctct aacttagtat      180

gtcttttttc cccccttaac atttgtattt tggagtggta tgtgtagcaa ctggttctcg      240

ccaaggtggg ataccttcta gttaacagtc acaccattca tgacatatcc atggaatagg      300

atcgtgccta ataggggcaa tgcccggctc tttctacagc agactcttcc ccgaggagtc      360

catgcatttt ttacactctt gttactgtct tcaatggtta tctcaggtct ttgagttaat      420

cccttttatc tttttaattt ttcttgtagc aaaaatagtt catgattttc attcaacaca      480

ttagtaacta tgcacggaaa tttctttaat aattctcaag atatccacag gaatccaaga      540

aagagatttc tgaagaaact aataacatat tttattcaag tcgtggctca tgatttatat      600

tcccacatgc aacactaaca aa                                               622


