
                                SEQUENCE LISTING

<110> Rivella, Stefano
      Breda, Laura
      Dong, Alisa
      Lourenco, Silvia Pires
      Gonzalez, Amaliris

<120> Compositions and Methods for
  Hemoglobulin Production

<130> 3460-P06579WO00

<140> PCT/US2019/029787   
<141> 2019-04-30  

<150> 62/664,788          
<151> 2018-04-30  

<160> 6

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 14135
<212> DNA
<213> Artificial Sequence

<220> 
<223> ALS17

<400> 1
ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt 60
aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag 120
ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct 180
ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt 240
tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg 300
cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct 360
gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc 420
gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg 480
tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa 540
ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg 600
gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg 660
ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga 720
tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt 780
ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct 840
gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga 900
acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg 960
cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg 1020
aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta ggcaccccag 1080
gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt 1140
cacacaggaa acagctatga ccatgattac gccaagcgcg caattaaccc tcactaaagg 1200
gaacaaaagc tggagctgca agcttggcca ttgcatacgt tgtatccata tcataatatg 1260
tacatttata ttggctcatg tccaacatta ccgccatgtt gacattgatt attgactagt 1320
tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt 1380
acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg 1440
tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg 1500
gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt 1560
acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg 1620
accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg 1680
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt 1740
ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac 1800
tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg 1860
tgggaggtct atataagcag agctcgttta gtgaaccggg gtctctctgg ttagaccaga 1920
tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct 1980
tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat 2040
ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga acagggacct 2100
gaaagcgaaa gggaaaccag agctctctcg acgcaggact cggcttgctg aagcgcgcac 2160
ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta gcggaggcta 2220
gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta gatcgcgatg 2280
ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac atatagtatg 2340
ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa catcagaagg 2400
ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag aagaacttag 2460
atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag agataaaaga 2520
caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga ccaccgcaca 2580
gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat tggagaagtg 2640
aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc accaaggcaa 2700
agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt 2760
tcttgggagc agcaggaagc actatgggcg cagcctcaat gacgctgacg gtacaggcca 2820
gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc 2880
aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg 2940
ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac 3000
tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct ctggaacaga 3060
tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac acaagcttaa 3120
tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg 3180
aattagataa atgggcaagt ttgtggaatt ggtttaacat aacaaattgg ctgtggtata 3240
taaaattatt cataatgata gtaggaggct tggtaggttt aagaatagtt tttgctgtac 3300
tttctatagt gaatagagtt aggcagggat attcaccatt atcgtttcag acccacctcc 3360
caaccccgag gggacccgac aggcccgaag gaatagaaga agaaggtgga gagagagaca 3420
gagacagatc cattcgatta gtgaacggat ctcgacggta tcggttaact tttaaaagaa 3480
aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca 3540
tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttatc gataagcttg 3600
ggagttccgc gtgttggggg tggaccatcc tctaggtatt gaataagaaa aatgaagtta 3660
aggtggttga tggtaacact atgctaataa ctgcagagcc agaagcacca taagggacat 3720
gataagggag ccagcagacc tctgatctct tcctgaatgc taatcttaaa catcctgagg 3780
aagaatggga cttccatttg gggtgggcct atgatagggt aataagacag tagtgaatat 3840
caagctacaa aaagccccct ttcaaattct tctcagtcct aacttttcat actaagccca 3900
gtccttccaa agcagactgt gaaagagtga tagttccggg agactagcac tgcagattcc 3960
gggtcactgt gagtggggga ggcagggaag aagggctcac aggacagtca aaccatgccc 4020
cctgtttttc cttcttcaag tagacctcta taagacaaca gagacaacta aggctgagtg 4080
gccaggcgag gagaaaccat ctcgccgtaa aacatggaag gaacacttca ggggaaaggt 4140
ggtatctcta agcaagagaa ctgagtggag tcaaggctga gagatgcagg ataagcaaat 4200
gggtagtgaa aagacattca tgaggacagc taaaacaata agtaatgtaa aatacagcat 4260
agcaaaactt taacctccaa atcaagcctc tacttgaatc cttttctgag ggatgaataa 4320
ggcataggca tcaggggctg ttgccaatgt gcattagctg tttgcagcct caccttcttt 4380
catggagttt aagatatagt gtattttccc aaggtttgaa ctagctcttc atttctttat 4440
gttttaaatg cactgacctc ccacattccc tttttagtaa aatattcaga aataatttaa 4500
atacatcatt gcaatgaaaa taaatgtttt ttattaggca gaatccagat gctcaaggcc 4560
cttcataata tcccccagtt tagtagttgg acttagggaa caaaggaacc tttaatagaa 4620
attggacagc aagaaagcga gcttagtgat acttgtgggc cagggcatta gccacaccag 4680
ccaccacttt ctgataggca gcctgcactg gtggggtgaa ttctttgcca aagtgatggg 4740
ccagcacaca gaccagcacg ttgcccagga gctgtgggag gaagataaga ggtatgaaca 4800
tgattagcaa aagggcctag cttggactca gaataatcca gccttatccc aaccataaaa 4860
taaaagcaga atggtagctg gattgtagct gctattagca atatgaaacc tcttacatca 4920
gttacaattt atatgcagaa atatttatat gcagaaatat tgctattgcc ttaacccaga 4980
aattatcact gttattcttt agaatggtgc aaagaggcat gatacattgt atcattattg 5040
ccctgaaaga aagagattag ggaaagtatt agaaataaga taaacaaaaa agtatattaa 5100
aagaagaaag cattttttaa aattacaaat gcaaaattac cctgatttgg tcaatatgtg 5160
tacacatatt aaaacattac actttaaccc ataaatatgt ataatgatta tgtatcaatt 5220
aaaaataaaa gaaaataaag tagggagatt atgaatatgc aaataagcac acatatattc 5280
caaatagtaa tgtactaggc agactgtgta aagttttttt ttaagttact taatgtatct 5340
cagagatatt tccttttgtt atacacaatg ttaaggcatt aagtataata gtaaaaattg 5400
cggagaagaa aaaaaaagaa agcaagaatt aaacaaaaga aaacaattgt tatgaacagc 5460
aaataaaaga aactaaaacg atcctgagac ttccacactg atgcaatcat tcgtctgttt 5520
cccattctaa actgtaccct gttacttctc cccttcctat gacatgaact taaccataga 5580
aaagaagggg aaagaaaaca tcaagggtcc catagactca ccctgaagtt ctcaggatcc 5640
acgtgcagct tgtcacagtg cagctcactc actgtggcaa aggtgccctt gaggttgtcc 5700
aggtgagcca ggccatcact aaaggcaccg agcactttct tgccatgagc cttcacctta 5760
gggttgccca taacagcatc aggagtggac agatccccaa aggactcaaa gaacctctgg 5820
gtccaagggt agaccaccag cagcctaagg gtgggaaaat agaccaatag gcagagagag 5880
tcagtgccta tcagaaaccc aagagtcttc tctgtctcca catgcccagt ttctattggt 5940
ctccttaaac ctgtcttgta accttgatac caacctgccc agggcctcac caccaacttc 6000
atccacgttc accttgcccc acagggcagt aacggcagac ttctcctcag gagtcaggtg 6060
caccatggtg tctgtttgag gttgctagtg aacacagttg tgtcagaagc aaatgtaagc 6120
aatagatggc tctgccctga cttttatgcc cagccctggc tcctgccctc cctgctcctg 6180
ggagtagatt ggccaaccct agggtgtggc tccacagggt gaggtctaag tgatgacagc 6240
cgtacctgtc cttggctctt ctggcactgg cttaggagtt ggacttcaaa ccctcagccc 6300
tccctctaag atatatctct tggccccata ccatcagtac aaattgctac taaaaacatc 6360
ctcctttgca agtgtattta cgtaatattt ggaatcacag cttggtaagc atattgaaga 6420
tcgttttccc aattttctta ttacacaaat aagaaattga tgcactaaaa gtggaagagt 6480
tttgtctacc ataattcagc tttgggatat gtagatggat ctcttcctgc gtctccagaa 6540
tatgcaaaat acttacagga cagaatggat gaaaactcta cctcagttct aagcatatct 6600
tctccttatt tggattaaaa ccttctggta agaaaagaaa aaaaatatat atatatatgt 6660
gtatatatac acacatacat atacatatat atgcattcat ttgttgttgt ttttcttaat 6720
ttgctcatgg tatatgtgta tatatatata tatatattca ggaaataata tattctagac 6780
tcaagcctca ttcagacact agtgtcacca gtctcctcat atacctattg tattttcttc 6840
ttcttgctgg tttagtcatg ttttctggga gcttaggggc ttattttatt ttgttttgtt 6900
ttctaatcaa cagagatggg caaacccatt atttttttct ttagacttgg gatggtgata 6960
gctgggcagc gtcagaaact gtgtgtggat atagataaga gctcaggact atgctgagct 7020
gtgatgaggg aggggcctag ctaaaggcag tgagagtcag aatgctcctg ctattgcctt 7080
ctcagtcccc acgcttggtt tctacacaag tagatacata gaaaaggcta taggttagtg 7140
tttgagagtc ctgcatgatt agttgctcag aaatgcccga taaatatgtt atgtgtgttt 7200
atgtatatat atgttttata tatatatata tgtgtgtgtg tgtgtgtgtg tgtgttgtgt 7260
ttacaaatat gtgattatca tcaaaacgtg agggctaaag tgaccagata acttgcaagt 7320
cctaggatac caggaaatct agaatatgtc acattctgtc tcaggcatcc attttcttta 7380
tgatgccgtt tgaggtggag ttttagtcag gtggtcagct tctccttttt tttgccatct 7440
gccctgtaag catcctgctg gggacccaga taggagtcat cactctaggc tgagaacatc 7500
tgggcacaca ccctaagcct cagcatgact catcatgact cagcattgct gtgcttgagc 7560
cagaaggttt gcttagaagg ttacacagaa ccagaaggcg ggggtggggc actgaccccg 7620
acaggggcct ggccagaact gctcatgctt ggactatggg aggtcactaa tggagacaca 7680
cagaaatgta acaggaacta aggaaaaact gaagcttatt taatcagaga tgagatgctg 7740
gaagggatag agggagctga gcttgtaaaa agtatagtaa tcattcagca aatggttttg 7800
aagcacctgc tggatgctaa acactatttt cagtgcttga atcataaata agaataaaac 7860
atgtatctta ttccccacaa gagtccaagt aaaaaataac agttaattat aatgtgctct 7920
gtcccccagg ctggagtgca gtggcacgat ctcagctcac tgcaacctcc gcctcccggg 7980
ttcaagcaat tctcctgcct cagccaccct aatagctggg attacaggtg cacaccacca 8040
tgccaggcta atttttgtac tttttgtaga ggcagggtat caccatgttg tccaagatgg 8100
tcttgaactc ctgagctcca agcagtccac ccacctcagc ctcccaaagt gctatctgcg 8160
gccgcctatc tgtaccacta gtctcgagaa gctttcatta aaaaaagtct aaccagctgc 8220
attcgacttt gactgcagca gctggttaga aggttctact ggaggagggt cccagcccat 8280
tgctaaatta acatcaggct ctgagactgg cagtatatct ctaacagtgg ttgatgctat 8340
cttctggaac ttgcctgcta cattgagacc actgacccat acataggaag cccatagctc 8400
tgtcctgaac tgttaggcca ctggtccaga gagtgtgcat ctcctttgat cctcataata 8460
accctatgag atagacacaa ttattactct tactttatag atgatgatcc tgaaaacata 8520
ggagtcaagg cacttgcccc tagctggggg tataggggag cagtcccatg tagtagtaga 8580
atgaaaaatg ctgctatgct gtgcctcccc cacctttccc atgtctgccc tctactcatg 8640
gtctatctct cctggctcct gggagtcatg gactccaccc agcaccacca acctgaccta 8700
accacctatc tgagcctgcc agcctataac ccatctgggc cctgatagct ggtggccagc 8760
cctgacccca ccccaccctc cctggaacct ctgatagaca catctggcac accagctcgc 8820
aaagtcaccg tgagggtctt gtgtttgctg agtcaaaatt ccttgaaatc caagtcctta 8880
gagactcctg ctcccaaatt tacagtcata gacttcttca tggctgtctc ctttatccac 8940
agaatgattc ctttgcttca ttgccccatc catctgatcc tcctcatcag tgcagcacag 9000
ggcccatgag cagtagctgc agagtctcac ataggtctgg cactgcctct gacatgtccg 9060
accttaggca aatgcttgac tcttctgagc tcagtcttgt catggcaaaa taaagataat 9120
aatagtgttt ttttatggag ttagcgtgag gatggaaaac aatagcaaaa ttgattagac 9180
tataaaaggt ctcaacaaat agtagtagat tttatcatcc attaatcctt ccctctcctc 9240
tcttactcat cccatcacgt atgcctctta attttccctt acctataata agagttattc 9300
ctcttattat attcttctta tagtgattct ggatattaaa gtgggaatga ggggcaggcc 9360
actaacgaag aagatgtttc tcaaagaagc cattctcccc acatagatca tctcagcagg 9420
gttcaggaag ataaaggagg atcaaggtcg aaggtaggaa ctaaggaaga acactgggac 9480
cggtactagt gcatgcaaat ctgacactca gtgggcctgg gtgaaggtga gaattttatt 9540
gctgaatgag agcctctggg gacatcttgc cagtcaatga gtctcaggtt caatttcctt 9600
ctcagtcttg gagtaacaga agctcatgca tttaataaac ggaaattttg tattgaaatg 9660
agagccattg gaaatcattt actccagact cctacttata aaaagagaaa ctgaggctca 9720
gagaagggtg gggactttct cagtatgaca tggaaatgat caggcttgga ttcaaagctc 9780
ctgactttct gtctagtgta tgtgcagtga gccccttttc ctctaactga aagaaggaaa 9840
aaaaaatgga acccaaaata ttctacatag tttccatgtc acagccaggg ctgggcagtc 9900
tcctgttatt tcttttaaaa taaatatatc atttaaatgc ataaataagc aaaccctgct 9960
cgggaatggg agggagagtc tctggagtcc accccttctc ggccctggct ctgcagatag 10020
tgctatcaaa gccctgacag agccctgccc attgctgggc cttggagtga gtcagcctag 10080
tagagaggca gggcaagcca tctcatagct gctgagtggg agagagaaaa gggctcattg 10140
tctataaact caggtcatgg ctattcttat tctcacacta agaaaaagaa tgagatgtct 10200
acatataccc tgcgtcccct cttgtgtact ggggtcccca agagctctct aaaagtgatg 10260
gcaaagtcat tgcgctagat gccatcccat ctattataaa cctgcatttg tctccacaca 10320
ccagtcatgg acaataaccc tcctcccagg tccacgtgct tgtctttgta taatactcaa 10380
gtaatttcgg aaaatgtatt ctttcaatct tgttctgtta ttcctgtttc aatggcttag 10440
tagaaaaagt acatacttgt tttcccataa attgacaata gacaatttca catcaatgtc 10500
tatatgggtc gttgtgtttg ctgtgtttgc aaaaactcac aataacttta tattgttact 10560
actctaagaa agttacaaca tggtgaatac aagagaaagc tattacaagt ccagaaaata 10620
aaagttatca tcttgaggcc tcctgcaggg tacctttaag accaatgact tacaaggcag 10680
ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta attcactccc 10740
aacgaagaca agatctgctt tttgctgtgc gggccaggcc cccgagggcc ttatcggccc 10800
cagaggcgct tgctgtcggg ccgggcgctc ccggcacggg cgggcggagg ggtggcgccc 10860
gcctggggac cgcagattac aagagcacct cctcccccaa ccccaggagg ccccgctccc 10920
caggcctcgg ccggcgcgga cccctggttg ccccggactg ggtctctctg gttagaccag 10980
atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc 11040
ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga 11100
tccctcagac ccttttagtc agtgtggaaa atctctagca ggctagcaaa caaaagacgt 11160
acgagctatg ctttaattaa agctatgctg tcgacaatca acctctggat tacaaaattt 11220
gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg 11280
ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt 11340
ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg 11400
tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc 11460
agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg 11520
cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt 11580
tgtcggggaa gctgacgtcc tttccatggc tgctcgcctg tgttgccacc tggattctgc 11640
gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg 11700
gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga 11760
tctccctttg ggccgcctcc ccgcctggaa ttcgagctcg gtacctgatc agcctcgact 11820
gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg 11880
gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg 11940
agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg 12000
gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga ggaaagaacc 12060
agctggggct cgagatccac tagttctagc ctcgaggcta gagcggccgc caccgcggta 12120
gtagttcatg tcatcttatt attcagtatt tataacttgc aaagaaatga atatcagaga 12180
gtgagaggaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 12240
atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 12300
atgtatctta tcatgtctgg ctctagctat cccgccccta actccgccca gttccgccca 12360
ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc 12420
ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcgtcga 12480
gacgtaccca attcgcccta tagtgagtcg tattacgcgc gctcactggc cgtcgtttta 12540
caacgtcgtg actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc 12600
cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg 12660
cgcagcctga atggcgaatg gcgcgacgcg ccctgtagcg gcgcattaag cgcggcgggt 12720
gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc 12780
gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg 12840
gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat 12900
tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg 12960
ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct 13020
atctcggtct attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa 13080
aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt 13140
tcccaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa 13200
tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt 13260
gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg 13320
cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag 13380
atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg 13440
agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg 13500
gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt 13560
ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga 13620
cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac 13680
ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc 13740
atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc 13800
gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac 13860
tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag 13920
gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg 13980
gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta 14040
tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg 14100
ctgagatagg tgcctcactg attaagcatt ggtaa                            14135



<210> 2
<211> 400
<212> DNA
<213> Artificial Sequence

<220> 
<223> shRNAmiR5mod within intron 1

<400> 2
ataatgatta tgtatcaatt aaaaataaaa gaaaataaag tagggagatt atgaatatgc 60
aaataagcac acatatattc caaatagtaa tgtactaggc agactgtgta aagttttttt 120
ttaagttact taatgtatct cagagatatt tccttttgtt atacacaatg ttaaggcatt 180
aagtataata gtaaaaattg cggagaagaa aaaaaaagaa agcaagaatt aaacaaaaga 240
aaacaattgt tatgaacagc aaataaaaga aactaaaacg atcctgagac ttccacactg 300
atgcaatcat tcgtctgttt cccattctaa actgtaccct gttacttctc cccttcctat 360
gacatgaact taaccataga aaagaagggg aaagaaaaca                       400

<210> 3
<211> 92
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding region within the beta-globin gene

<400> 3
ctgcccaggg cctcaccacc aacttcatcc acgttcacct tgccccacag ggcagtaacg 60
gcagacttct cctcaggagt cagatgcacc at                               92

<210> 4
<211> 92
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding region within the beta-globin gene

<400> 4
ctgcccaggg cctcgccgcc gacttcatcc acgttcacct tgccccacag ggcagtaacg 60
gcagacttct cctcaggagt cagatgcacc at                               92

<210> 5
<211> 100
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding region within the beta-globin gene

<400> 5
actcagtgtg gcaaaggtgc ccttgaggtt gtccaggtga gccaggccat cactaaaggc 60
accgagcact ttcttgccat gagccttcac cttagggttg                       100

<210> 6
<211> 100
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding region within the beta-globin gene

<400> 6
actcagtgtg gcaaaggtgc ccttgaggtt gtccaggtga gccaggccat cggagaaggc 60
accgagcact ttcttgccat gagccttcac cttagggttg                       100
