                         SEQUENCE LISTING

<110>  Integral Molecular, Inc.
       Tucker, David F.
       Mattia, Kimberly-Anne
       Fisher, Christine R.
       Doranz, Benjamin J.
       Rucker, Joseph B.
 
<120>  GLUCOSE TRANSPORTER 4 ANTIBODIES, METHODS OF MAKING THE SAME, AND
        USES THEREOF

<130>  134088.01602

<150>  62/664,470
<151>  2018-04-30

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ser Gly Phe Gln Gln Ile Gly Ser Glu Asp Gly Glu Pro Pro 
1               5                   10                  15      


Gln Gln Arg Val Thr Gly Thr Leu Val Leu Ala Val Phe Ser Ala Val 
            20                  25                  30          


Leu Gly Ser Leu Gln Phe Gly Tyr Asn Ile Gly Val Ile Asn Ala Pro 
        35                  40                  45              


Gln Lys Val Ile Glu Gln Ser Tyr Asn Glu Thr Trp Leu Gly Arg Gln 
    50                  55                  60                  


Gly Pro Glu Gly Pro Ser Ser Ile Pro Pro Gly Thr Leu Thr Thr Leu 
65                  70                  75                  80  


Trp Ala Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Ser Ser 
                85                  90                  95      


Phe Leu Ile Gly Ile Ile Ser Gln Trp Leu Gly Arg Lys Arg Ala Met 
            100                 105                 110         


Leu Val Asn Asn Val Leu Ala Val Leu Gly Gly Ser Leu Met Gly Leu 
        115                 120                 125             


Ala Asn Ala Ala Ala Ser Tyr Glu Met Leu Ile Leu Gly Arg Phe Leu 
    130                 135                 140                 


Ile Gly Ala Tyr Ser Gly Leu Thr Ser Gly Leu Val Pro Met Tyr Val 
145                 150                 155                 160 


Gly Glu Ile Ala Pro Thr His Leu Arg Gly Ala Leu Gly Thr Leu Asn 
                165                 170                 175     


Gln Leu Ala Ile Val Ile Gly Ile Leu Ile Ala Gln Val Leu Gly Leu 
            180                 185                 190         


Glu Ser Leu Leu Gly Thr Ala Ser Leu Trp Pro Leu Leu Leu Gly Leu 
        195                 200                 205             


Thr Val Leu Pro Ala Leu Leu Gln Leu Val Leu Leu Pro Phe Cys Pro 
    210                 215                 220                 


Glu Ser Pro Arg Tyr Leu Tyr Ile Ile Gln Asn Leu Glu Gly Pro Ala 
225                 230                 235                 240 


Arg Lys Ser Leu Lys Arg Leu Thr Gly Trp Ala Asp Val Ser Gly Val 
                245                 250                 255     


Leu Ala Glu Leu Lys Asp Glu Lys Arg Lys Leu Glu Arg Glu Arg Pro 
            260                 265                 270         


Leu Ser Leu Leu Gln Leu Leu Gly Ser Arg Thr His Arg Gln Pro Leu 
        275                 280                 285             


Ile Ile Ala Val Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn 
    290                 295                 300                 


Ala Val Phe Tyr Tyr Ser Thr Ser Ile Phe Glu Thr Ala Gly Val Gly 
305                 310                 315                 320 


Gln Pro Ala Tyr Ala Thr Ile Gly Ala Gly Val Val Asn Thr Val Phe 
                325                 330                 335     


Thr Leu Val Ser Val Leu Leu Val Glu Arg Ala Gly Arg Arg Thr Leu 
            340                 345                 350         


His Leu Leu Gly Leu Ala Gly Met Cys Gly Cys Ala Ile Leu Met Thr 
        355                 360                 365             


Val Ala Leu Leu Leu Leu Glu Arg Val Pro Ala Met Ser Tyr Val Ser 
    370                 375                 380                 


Ile Val Ala Ile Phe Gly Phe Val Ala Phe Phe Glu Ile Gly Pro Gly 
385                 390                 395                 400 


Pro Ile Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg 
                405                 410                 415     


Pro Ala Ala Met Ala Val Ala Gly Phe Ser Asn Trp Thr Ser Asn Phe 
            420                 425                 430         


Ile Ile Gly Met Gly Phe Gln Tyr Val Ala Glu Ala Met Gly Pro Tyr 
        435                 440                 445             


Val Phe Leu Leu Phe Ala Val Leu Leu Leu Gly Phe Phe Ile Phe Thr 
    450                 455                 460                 


Phe Leu Arg Val Pro Glu Thr Arg Gly Arg Thr Phe Asp Gln Ile Ser 
465                 470                 475                 480 


Ala Ala Phe His Arg Thr Pro Ser Leu Leu Glu Gln Glu Val Lys Pro 
                485                 490                 495     


Ser Thr Glu Leu Glu Tyr Leu Gly Pro Asp Glu Asn Asp 
            500                 505                 


<210>  2
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  2

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Ser Ser Asn Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Asp Ser 
    50                  55                  60                  


Thr His Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Tyr Asp Ser Thr Tyr Val Gly Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg Ser Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr Leu Asp Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Gln Thr Pro Gly Gly Thr Leu Ser Leu Val Cys Lys 
    130                 135                 140                 


Ala Ser Gly Phe Thr Phe Ser Ser Asn Ala Met Gly Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Gly Ile Ser Ser Asp Gly 
                165                 170                 175     


Arg Tyr Thr Lys Tyr Gly Ser Ala Val Lys Gly Arg Ala Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Gly Gln Ser Thr Val Arg Leu Gln Leu Asn Asn Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Gly Thr Tyr Phe Cys Ala Lys Ala Phe Gly Asn Asn 
    210                 215                 220                 


Tyr Arg Arg Ile Tyr Ala Gly Gln Ile Asp Ala Trp Gly His Gly Thr 
225                 230                 235                 240 


Glu Val Ile Val Ser Ser 
                245     


<210>  3
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  3

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Gly Tyr Gly Trp Tyr Gln 
            20                  25                  30          


Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Ser Asn Asp 
        35                  40                  45              


Gln Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Ile Tyr Tyr Cys Gly Ser Thr Asp Ser Asp Tyr Val Gly Ile Phe Gly 
                85                  90                  95      


Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg Ser Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr Leu Asp Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Thr Leu Ser Leu Val Cys 
    130                 135                 140                 


Lys Ala Ser Gly Phe Asp Phe Ser Ser Tyr Ala Thr Ile Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Gly Ile Ser Gly Thr 
                165                 170                 175     


Gly Thr Gly Ser Ser Thr Gly Tyr Ala Pro Ala Val Lys Gly Arg Ala 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg Leu Gln Leu Asn 
        195                 200                 205             


Asn Leu Arg Ala Glu Asp Thr Gly Ser Tyr Phe Cys Ala Lys Ser Thr 
    210                 215                 220                 


Gly Tyr Gly Asp Ser Trp Ile Tyr Pro Asp Ser Ile Asp Ala Trp Gly 
225                 230                 235                 240 


His Gly Thr Glu Val Ile Val Ser Ser 
                245                 


<210>  4
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  4

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Asp Ser Ser Tyr Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Ala Asn Thr Asn 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Ser Ala Asp Ser Thr Tyr Ala Gly Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg Ser Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr Leu Asp Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Ser Leu Ile Cys Lys 
    130                 135                 140                 


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met Asn Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Val Ile Ser Asn Ser Gly 
                165                 170                 175     


Arg Thr Thr Asn Tyr Gly Ala Ala Val Gln Gly Arg Ala Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Gly Gln Ser Thr Val Arg Leu Gln Leu Asn Asn Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Ala Lys Ser Ser Ala Ser Ala 
    210                 215                 220                 


Ser Cys Ala Trp Trp Ala Gly Arg Ser Tyr Pro Cys Ser Ala Asn Arg 
225                 230                 235                 240 


Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250                 


<210>  5
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  5

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Ser Ser Gly Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ala Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Arg Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Gly Tyr Asp Ser Ser Ala Gly Tyr Ala Ala Phe Gly 
                85                  90                  95      


Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg Ser Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr Leu Asp Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Ser Leu Val Cys 
    130                 135                 140                 


Lys Ala Ser Gly Phe Thr Phe Ser Ser His Gly Met Gly Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Ser Ile Ser Thr Gly 
                165                 170                 175     


Arg Tyr Thr Phe Tyr Ala Pro Ala Val Lys Gly Arg Ala Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Gly Gln Ser Thr Leu Arg Leu Gln Leu Asn Asn Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Thr Lys Cys Ala Gly Leu Asn 
    210                 215                 220                 


Gly Cys Gly Gly Gly Glu Ile Asp Ala Trp Gly His Gly Thr Glu Val 
225                 230                 235                 240 


Ile Val Ser Ser 
                


<210>  6
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  6

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Ser Gly Ser Trp Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Ser Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ser Thr Leu Thr Ile Thr Gly Val Gln Val Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Asn Trp Asp Ile Phe Gly Ala Gly Thr Thr Leu Thr 
                85                  90                  95      


Val Leu Gly Gln Ser Ser Arg Ser Ser Gly Gly Gly Gly Ser Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln 
        115                 120                 125             


Thr Pro Gly Gly Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr 
    130                 135                 140                 


Phe Ser Ser His Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly 
145                 150                 155                 160 


Leu Glu Trp Val Ala Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala 
                165                 170                 175     


Pro Ala Val Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser 
            180                 185                 190         


Thr Val Arg Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr 
        195                 200                 205             


Tyr Tyr Cys Thr Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu 
    210                 215                 220                 


Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
225                 230                 235             


<210>  7

<400>  7
000

<210>  8
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  8

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Ser Ser Asn Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Asp Ser 
    50                  55                  60                  


Thr His Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Tyr Asp Ser Thr Tyr Val Gly Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  9
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  9

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Gly Tyr Gly Trp Tyr Gln 
            20                  25                  30          


Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Ser Asn Asp 
        35                  40                  45              


Gln Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Ile Tyr Tyr Cys Gly Ser Thr Asp Ser Asp Tyr Val Gly Ile Phe Gly 
                85                  90                  95      


Ala Gly Thr Thr Leu Thr Val Leu 
            100                 


<210>  10
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  10

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Asp Ser Ser Tyr Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Ala Asn Thr Asn 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Ser Ala Asp Ser Thr Tyr Ala Gly Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  11
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  11

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Ser Ser Gly Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ala Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Arg Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Gly Tyr Asp Ser Ser Ala Gly Tyr Ala Ala Phe Gly 
                85                  90                  95      


Ala Gly Thr Thr Leu Thr Val Leu 
            100                 


<210>  12
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  12

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Ser Gly Ser Trp Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Ser Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ser Thr Leu Thr Ile Thr Gly Val Gln Val Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Asn Trp Asp Ile Phe Gly Ala Gly Thr Thr Leu Thr 
                85                  90                  95      


Val Leu 
        


<210>  13
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  13

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Ser Asp Gly Arg Tyr Thr Lys Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Ala Lys Ala Phe Gly Asn Asn Tyr Arg Arg Ile Tyr Ala Gly Gln Ile 
            100                 105                 110         


Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  14
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  14

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Ala Thr Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Gly Thr Gly Thr Gly Ser Ser Thr Gly Tyr Ala Pro 
    50                  55                  60                  


Ala Val Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr 
65                  70                  75                  80  


Val Arg Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Ser Tyr 
                85                  90                  95      


Phe Cys Ala Lys Ser Thr Gly Tyr Gly Asp Ser Trp Ile Tyr Pro Asp 
            100                 105                 110         


Ser Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125         


<210>  15
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  15

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Ile Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Ser Asn Ser Gly Arg Thr Thr Asn Tyr Gly Ala Ala Val 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Ser Ala Ser Ala Ser Cys Ala Trp Trp Ala Gly Arg Ser 
            100                 105                 110         


Tyr Pro Cys Ser Ala Asn Arg Ile Asp Ala Trp Gly His Gly Thr Glu 
        115                 120                 125             


Val Ile Val Ser Ser 
    130             


<210>  16
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  16

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala Pro Ala Val Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp Ala Trp 
            100                 105                 110         


Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120         


<210>  17
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  17

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala Pro Ala Val Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp Ala Trp 
            100                 105                 110         


Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120         


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  18

Cys Ser Gly Ser Ser Asn Ser Tyr Gly 
1               5                   


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  19

Ile Tyr Tyr Asn Asp Lys Arg Pro 
1               5               


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  20

Cys Gly Ser Tyr Asp Ser Thr Tyr Val Gly Ile Phe 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  21

Gly Phe Thr Phe Ser Ser Asn Ala Met Gly Trp Val 
1               5                   10          


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  22

Val Ala Gly Ile Ser Ser Asp Gly Arg Tyr Thr Lys Tyr Gly 
1               5                   10                  


<210>  23
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  23

Cys Ala Lys Ala Phe Gly Asn Asn Tyr Arg Arg Ile Tyr Ala Gly Gln 
1               5                   10                  15      


Ile Asp Ala 
            


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  24

Cys Ser Gly Gly Gly Ser Tyr Gly Tyr Gly 
1               5                   10  


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  25

Ile Tyr Ser Asn Asp Gln Arg Pro 
1               5               


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  26

Cys Gly Ser Thr Asp Ser Asp Tyr Val Gly Ile Phe 
1               5                   10          


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  r

<400>  27

Gly Phe Asp Phe Ser Ser Tyr Ala Thr Ile Trp Val 
1               5                   10          


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  28

Val Ala Gly Ile Ser Gly Thr Gly Thr Gly Ser Ser Thr Gly Tyr Ala 
1               5                   10                  15      


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  29

Cys Ala Lys Ser Thr Gly Tyr Gly Asp Ser Trp Ile Tyr Pro Asp Ser 
1               5                   10                  15      


Ile Asp Ala 
            


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  30

Cys Ser Gly Ser Ser Ser Gly Tyr Gly 
1               5                   


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  31

Ile Tyr Asn Ser Asn Lys Arg Pro 
1               5               


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  32

Cys Gly Asn Arg Asp Ser Thr Asn Ser Ala Gly Ile Phe 
1               5                   10              


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  33

Gly Phe Thr Phe Ser Asp Tyr Gly Met Gly Trp Val 
1               5                   10          


<210>  34
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  34

Val Ala Ala Ile Thr Ser Ser Gly Arg Tyr Thr Tyr Tyr Gly 
1               5                   10                  


<210>  35
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  35

Cys Ala Lys Thr Thr Ser Thr Cys Ala Ser Cys Val Ala Tyr Ser Ile 
1               5                   10                  15      


Asp Ala 
        


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  r

<400>  36

Cys Ser Gly Gly Gly Ser Tyr Tyr Gly 
1               5                   


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  37

Ile Tyr Tyr Asn Asp Lys Arg Pro 
1               5               


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  38

Cys Gly Ser Trp Asp Ser Ser Thr Asn Thr Ala Phe 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  39

Gly Phe Thr Phe Ser Ser His Gly Met Gly Trp Val 
1               5                   10          


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  40

Val Ala Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala 
1               5                   10              


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  41

Cys Thr Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp 
1               5                   10                  15      


Ala 
    


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  42

Cys Ser Gly Asp Ser Ser Tyr Tyr Gly 
1               5                   


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  43

Ile Tyr Ala Asn Thr Asn Arg Pro 
1               5               


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  44

Cys Gly Ser Ala Asp Ser Thr Tyr Ala Gly Ile Phe 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  45

Gly Phe Thr Phe Ser Ser Tyr Thr Met Asn Trp Val 
1               5                   10          


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  46

Val Gly Val Ile Ser Asn Ser Gly Arg Thr Thr Asn Tyr Gly 
1               5                   10                  


<210>  47
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  47

Cys Ala Lys Ser Ser Ala Ser Ala Ser Cys Ala Trp Trp Ala Gly Arg 
1               5                   10                  15      


Ser Tyr Pro Cys Ser Ala Asn Arg Ile Asp Ala 
            20                  25          


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  48

Cys Ser Gly Gly Gly Ser Tyr Gly 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  49

Ile Tyr Gly Asn Asp Lys Arg Pro 
1               5               


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  50

Cys Gly Ser Tyr Glu Asp Ser Ser Ala 
1               5                   


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  51

Gly Phe Thr Phe Ser Ser His Gly Met Gly Trp Val 
1               5                   10          


<210>  52
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  52

Val Ala Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala 
1               5                   10              


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  53

Cys Thr Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp 
1               5                   10                  15      


Ala 
    


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  54

Cys Ser Gly Gly Tyr Ser Gly Cys Gly Tyr Gly 
1               5                   10      


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  55

Ile Tyr Asp Asn Thr Asn Arg Pro 
1               5               


<210>  56
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  56

Cys Gly Ser Ala Asp Ser Ile Ser Tyr Asn Asp Tyr Val Gly 
1               5                   10                  


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  57

Gly Phe Ser Phe Ser Gly Tyr Gly Met Gly Trp Val 
1               5                   10          


<210>  58
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  58

Val Ala Gly Ile Asp Tyr Ser Gly Gly Gly Thr Glu Tyr Gly 
1               5                   10                  


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  59

Cys Thr Lys Cys Ala Tyr Ser Ser Gly Trp Cys Gly Asp Ser Ile Asp 
1               5                   10                  15      


Ala 
    


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  60

Cys Ser Gly Ser Ser Gly Ser Tyr Gly 
1               5                   


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  61

Ile Tyr Arg Asn Asp Lys Arg Pro 
1               5               


<210>  62
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  62

Cys Gly Gly Tyr Asp Ser Ser Ala Gly Tyr Ala Ala Phe 
1               5                   10              


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  63

Gly Phe Thr Phe Ser Ser His Gly Met Gly Trp Val 
1               5                   10          


<210>  64
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  64

Val Gly Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala 
1               5                   10              


<210>  65
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  65

Cys Thr Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp 
1               5                   10                  15      


Ala 
    


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  66

Cys Ser Gly Gly Gly Ser Trp Tyr Gly 
1               5                   


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  67

Ile Tyr Ser Asn Asn Lys Arg Pro 
1               5               


<210>  68
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  68

Cys Gly Ser Arg Asp Ser Ser Thr Tyr Val Gly Ile Phe 
1               5                   10              


<210>  69
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  69

Gly Phe Thr Phe Ser Ser Tyr Thr Met Gln Trp Val 
1               5                   10          


<210>  70
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  70

Val Ala Ala Ile Thr Ser Ser Gly Arg Tyr Thr Gly Tyr Gly 
1               5                   10                  


<210>  71
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  71

Cys Ala Arg Gly Gly Ser Val Asp Lys Ile Asp Ala 
1               5                   10          


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  72

Cys Ser Gly Ser Ser Ser Gly Ser Tyr Gly 
1               5                   10  


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  73

Ile Tyr Tyr Asn Asp Lys Arg Pro 
1               5               


<210>  74
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  74

Cys Gly Ser Tyr Asp Ser Ser Ala Gly Tyr Val Gly Ile Phe 
1               5                   10                  


<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  75

Gly Phe Thr Phe Ser Ser Tyr Thr Met Gln Trp Val 
1               5                   10          


<210>  76
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  76

Val Ala Gly Ile Gly Ser Ser Ser Tyr Thr Tyr Phe Gly 
1               5                   10              


<210>  77
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  77

Cys Ala Lys Gly Ala Ser Ala Thr Trp Ser Tyr Ala Tyr Ile Ala Ser 
1               5                   10                  15      


Arg Ile Gly Ala 
            20  


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  78

Cys Ser Gly Ser Gly Ser Trp Tyr Gly 
1               5                   


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  79

Ile Tyr Ser Asn Asp Lys Arg Pro 
1               5               


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  80

Cys Gly Asn Trp Asp Ile Phe 
1               5           


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  81

Gly Phe Thr Phe Ser Ser His Gly Met Gly Trp Val 
1               5                   10          


<210>  82
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  82

Val Ala Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala 
1               5                   10              


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  83

Cys Thr Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp 
1               5                   10                  15      


Ala 
    


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  84

Cys Ser Gly Gly Ser Asn Asn Tyr Gly 
1               5                   


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  r

<400>  85

Ile Tyr Arg Asn Asp Lys Arg Pro 
1               5               


<210>  86
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  86

Cys Gly Gly Tyr Asp Ser Ser Asn Tyr Val Ala Val Phe 
1               5                   10              


<210>  87
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  87

Gly Phe Thr Phe Ser Ser His Gly Met Gly Trp Val 
1               5                   10          


<210>  88
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  88

Val Ala Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala 
1               5                   10              


<210>  89
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  89

Cys Thr Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp 
1               5                   10                  15      


Ala 
    


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  90

Cys Ser Gly Ser Ser Gly Ser Ser Tyr Gly 
1               5                   10  


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  91

Ile Tyr Arg Asn Thr Gln Arg Pro 
1               5               


<210>  92
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  92

Cys Gly Ala Val Asp Ser Thr Gly Gly Ala Phe 
1               5                   10      


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  93

Gly Phe Thr Phe Asn Asp Tyr Gly Met Ala Trp Val 
1               5                   10          


<210>  94
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  94

Val Ala Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala 
1               5                   10              


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  95

Cys Thr Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp 
1               5                   10                  15      


Ala 
    


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  96

Cys Ser Gly Gly Ser Asn Asn Tyr Gly 
1               5                   


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  97

Ile Tyr Ala Asn Thr Lys Arg Pro 
1               5               


<210>  98
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  98

Cys Gly Ser Ala Asp Ser Arg Ala Gly Ile Phe 
1               5                   10      


<210>  99
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  99

Gly Phe Thr Phe Ser Ser His Gly Met Gly Trp Val 
1               5                   10          


<210>  100
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  100

Val Ala Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala 
1               5                   10              


<210>  101
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  101

Cys Thr Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp 
1               5                   10                  15      


Val 
    


<210>  102
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  102

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Ser Ser Ser Gly Tyr Gly Tyr Gly Trp Tyr 
            20                  25                  30          


Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Asn Ser 
        35                  40                  45              


Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser 
    50                  55                  60                  


Gly Ser Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Val Tyr Phe Cys Gly Asn Arg Asp Ser Thr Asn Ser Ala Gly Ile 
                85                  90                  95      


Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105     


<210>  103
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  103

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Ser Gly Arg Tyr Thr Tyr Tyr Gly Ala Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Lys Thr Thr Ser Thr Cys Ala Ser Cys Val Ala Tyr Ser Ile Asp 
            100                 105                 110         


Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 


<210>  104
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  104

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asn Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Ser Trp Asp Ser Ser Thr Asn Thr Ala Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  105
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  105

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala Pro Ala Val Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp Ala Trp 
            100                 105                 110         


Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120         


<210>  106
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  106

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Gly Trp Tyr Gln Gln Lys 
            20                  25                  30          


Ser Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Gly Asn Asp Lys Arg 
        35                  40                  45              


Pro Ser Asn Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser Thr 
    50                  55                  60                  


His Thr Leu Thr Ile Thr Gly Val Gln Ala Asp Asp Glu Ala Val Tyr 
65                  70                  75                  80  


Phe Cys Gly Ser Tyr Glu Asp Ser Ser Ala Gly Tyr Val Gly Ile Phe 
                85                  90                  95      


Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  107
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  107

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala Pro Ala Val Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp Ala Trp 
            100                 105                 110         


Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120         


<210>  108
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  108

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Gly Tyr Ser Gly Cys Gly Tyr Gly Trp Tyr 
            20                  25                  30          


Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Asp Asn 
        35                  40                  45              


Thr Asn Arg Pro Ser Asn Ile Pro Ser Arg Phe Ser Gly Ser Thr Ser 
    50                  55                  60                  


Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Val Tyr Tyr Cys Gly Ser Ala Asp Ser Ile Ser Tyr Asn Asp Tyr 
                85                  90                  95      


Val Gly Ile Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105                 


<210>  109
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  109

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Ser Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Tyr Ser Gly Gly Gly Thr Glu Tyr Gly Pro Ala Val 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Thr Lys Cys Ala Tyr Ser Ser Gly Trp Cys Gly Asp Ser Ile Asp Ala 
            100                 105                 110         


Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120             


<210>  110
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  110

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Trp Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Ser Asn Asn Lys 
        35                  40                  45              


Arg Pro Ser Asn Ile Pro Ser Arg Phe Ser Gly Ser Thr Ser Gly Ser 
    50                  55                  60                  


Thr Ser Thr Leu Thr Ile Thr Gly Val Gln Ala Asp Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Arg Asp Ser Ser Thr Tyr Val Gly Ile Phe Gly 
                85                  90                  95      


Ala Gly Thr Thr Leu Thr Val Leu 
            100                 


<210>  111
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  111

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Ser Gly Arg Tyr Thr Gly Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Val Asp Lys Ile Asp Ala Trp Gly His Gly Thr 
            100                 105                 110         


Glu Val Ile Val Ser Ser 
        115             


<210>  112
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  112

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Ser Ser Ser Gly Ser Tyr Gly Trp Tyr Gln 
            20                  25                  30          


Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp 
        35                  40                  45              


Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Ser Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Val Glu Asp Glu Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Gly Ser Tyr Asp Ser Ser Ala Gly Tyr Val Gly Ile 
                85                  90                  95      


Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105     


<210>  113
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  113

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Gly Ser Ser Ser Tyr Thr Tyr Phe Gly Pro Ala Val Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Phe Cys Ala 
                85                  90                  95      


Lys Gly Ala Ser Ala Thr Trp Ser Tyr Ala Tyr Ile Ala Ser Arg Ile 
            100                 105                 110         


Gly Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  114
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  114

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Gly Ser Asn Asn Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Arg Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ala Gly Ser Thr Ser Gly Ser 
    50                  55                  60                  


Ala Asn Thr Leu Thr Ile Thr Gly Val Gln Gly Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Gly Tyr Asp Ser Ser Asn Tyr Val Ala Val Phe Gly 
                85                  90                  95      


Ala Gly Thr Thr Leu Thr Val Leu 
            100                 


<210>  115
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  115

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala Pro Ala Val Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp Ala Trp 
            100                 105                 110         


Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120         


<210>  116
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  116

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Ser Ser Gly Ser Ser Tyr Gly Trp Tyr Gln 
            20                  25                  30          


Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Arg Asn Thr 
        35                  40                  45              


Gln Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Ser Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Val Glu Asp Glu Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Gly Ala Val Asp Ser Thr Gly Gly Ala Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  117
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  117

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala Pro Ala Val Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp Ala Trp 
            100                 105                 110         


Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120         


<210>  118
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  118

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Gly Ser Asn Asn Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Ala Asn Thr Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Ala Asp Ser Arg Ala Gly Ile Phe Gly Ala Gly 
                85                  90                  95      


Thr Thr Leu Thr Val Leu 
            100         


<210>  119
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  119

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Arg Tyr Thr Phe Tyr Ala Pro Ala Val Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Thr Thr Val Arg Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Cys Ala Gly Leu Asn Gly Cys Gly Gly Gly Glu Ile Asp Val Trp 
            100                 105                 110         


Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120         


<210>  120
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment

<400>  120

Gly Gln Ser Ser Arg Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Repeat from 1 to 5 times.

<400>  121

Gly Gly Gly Gly Ser 
1               5   


<210>  122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody fragment


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Repeat from 1 to 5 times.

<400>  122

Gly Gly Gly Gly Ala 
1               5   


