                         SEQUENCE LISTING

<110>  The Brigham and Women's Hospital, Inc.
 
<120>  COMPOSITIONS AND THERAPEUTIC METHODS OF MICRORNA GENE DELIVERY

<130>  51377-002WO2

<150>  US 62/664,362
<151>  2018-04-30

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
cttttcaatt tgaagagagt gcttcctctg ttcttaaggg gctagggaac caaattaggt       60

tgtttcaata tcgtgctaaa agatactgcc tttagaagaa ggctattgac aatccagcgt      120

gtctcggtgg aactctgact ccatggttca ctttcatgat ggccacatgc ctcctgccca      180

gagcccggca gccagtccag tgggaagggg ggccgataca ctgtacgaga gtgagtagca      240

ggtctcacag tgaaccggtc tctttcccta ctggacagct gcctcgggaa gccaagttgg      300

gctttaaagt gcagggcctg ctgatgttga gtgctttttg ttggcctctc tctccgtgtt      360

cacagcggac cttgatttaa atgtccatac aattaaggca cgcggtgaat gccaagaatg      420

gggctggcaa cactcctaat ggaatgccgt tatccaaaga gcagcacgaa cccgacaggg      480

ctgagtggct tgtgctaggg agaggtttgt gtcattcctg ctgaccaaac tgcaggaaaa      540

actgctaatt gtcatgctga agactgcctg acggggagac tctgccttct gtaagtaggt      600

catgtaaaga gcacgtgctc cttgctgct                                        629


<210>  2
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2
cttttcaatt tgaagagagt gcttcctctg ttcttaaggg gctagggaac caaattaggt       60

tgtttcaata tcgtgctaaa agatactgcc tttagaagaa ggctattgac aatccagcgt      120

gtctcggtgg aactctgact ccatggttca ctttcatgat ggccacatgc ctcctgccca      180

gagcccggca gccagtccag tgggaagggg ggccgataca ctgtacgaga gtgagtagca      240

ggtctcacag tgaaccggtc tctttcccta ctggacagct gcctcgggaa gccaagttgg      300

gctttaaagt gcagggcctg ctgatgttga gtgctttttg ttggcctctc tctccgtgtt      360

cacagcggac cttgatttaa atgtccatac aattaaggca cgcggtgaat gccaagaatg      420

gggctggcat aagaagttat gtattcatcc aataattcaa gccaagcaag tatataggtg      480

ttttaatagt ttttgtttgc actgactctc ttcggtgacg ggtattcttg ggtggataat      540

acggattacg ttgttattgc ttaagaatac gcgtagtcga ggagagtacc agtgcacact      600

cctaatggaa tgccgttatc caaagagcag cacgaacccg acagggctga gtggcttgtg      660

ctagggagag gtttgtgtca ttcctgctga ccaaactgca ggaaaaactg ctaattgtca      720

tgctgaagac tgcctgacgg ggagactctg ccttctgtaa gtaggtcatg taaagagcac      780

gtgctccttg ctgct                                                       795


<210>  3
<211>  1168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3
cttttcaatt tgaagagagt gcttcctctg ttcttaaggc tagggaacca aattaggttg       60

tttcaatatc gtgctaaaag atactgcctt tagaagaagg ctattgacaa tccagcgtgt      120

ctcggtggaa ctctgactcc atggttcact ttcatgatgg ccacatgcct cctgcccaga      180

gcccggcagc cagtccagtg ggaagggggg ccgatacact gtacgagagt gagtagcagg      240

tctcacagtg aaccggtctc tttccctact ggacagctgc ctcgggaagc caagttgggc      300

tttaaagtgc agggcctgct gatgttgagt gctttttgtt ggcctctctc tccgtgttca      360

cagcggacct tgatttaaat gtccatacaa ttaaggcacg cggtgaatgc caagaatggg      420

gctggcataa gaagttatgt attcatccaa taattcaagc caagcaagta tataggtgtt      480

ttaatagttt ttgtttgcac tgactctctt cggtgacggg tattcttggg tggataatac      540

ggattacgtt gttattgctt aagaatacgc gtagtcgagg agagtaccag tgctatttcc      600

ttcaaatgaa tgatttttac taattttgtg tacttttatt gtgtcgatgt agaatctgcc      660

tggtctatct gatgtgacag cttctgtagt ggaccggctg gccccatctg gaagactagt      720

gattttgttg ttgtcttact gcgctcaaca acaaatccca gtctacctaa tggtgccagc      780

catcgctgct agctgtagaa ctccagcttc ggcctgtcgc ccaatcaaac tgtcctgtta      840

ctgaacacgt gataatgtag cgagattttc tgttgtgctt gatctaacca tgtggttgcg      900

aggtatgagt aaaacatggt tccgtcaagc accatggaac gtcacgcagc tttctacgtg      960

acactcctaa tggaatgccg ttatccaaag agcagcacga acccgacagg gctgagtggc     1020

ttgtgctagg gagaggtttg tgtcattcct gctgaccaaa ctgcaggaaa aactgctaat     1080

tgtcatgctg aagactgcct gacggggaga ctctgccttc tgtaagtagg tcatgtaaag     1140

agcacgtgct ccttgctgct gcggccgc                                        1168


<210>  4
<211>  1314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4
cttttcaatt tgaagagagt gcttcctctg ttcttaaggg gctagggaac caaattaggt       60

tgtttcaata tcgtgctaaa agatactgcc tttagaagaa ggctattgac aatccagcgt      120

gtctcggtgg aactctgact ccatggttca ctttcatgat ggccacatgc ctcctgccca      180

gagcccggca gccagtccag tgggaagggg ggccgataca ctgtacgaga gtgagtagca      240

ggtctcacag tgaaccggtc tctttcccta ctggacagct gcctcgggaa gccaagttgg      300

gctttaaagt gcagggcctg ctgatgttga gtgctttttg ttggcctctc tctccgtgtt      360

cacagcggac cttgatttaa atgtccatac aattaaggca cgcggtgaat gccaagaatg      420

gggctggcat aagaagttat gtattcatcc aataattcaa gccaagcaag tatataggtg      480

ttttaatagt ttttgtttgc actgactctc ttcggtgacg ggtattcttg ggtggataat      540

acggattacg ttgttattgc ttaagaatac gcgtagtcga ggagagtacc agtgctattt      600

ccttcaaatg aatgattttt actaattttg tgtactttta ttgtgtcgat gtagaatctg      660

cctggtctat ctgatgtgac agcttctgta gtggaccggc tggccccatc tggaagacta      720

gtgattttgt tgttgtctta ctgcgctcaa caacaaatcc cagtctacct aatggtgcca      780

gccatcgctg ctagctgtag aactccagct tcggcctgtc gcccaatcaa actgtcctgt      840

tactgaacac gtgataatgt agcgagattt tctgttgtgc ttgatctaac catgtggttg      900

cgaggtatga gtaaaacatg gttccgtcaa gcaccatgga acgtcacgca gctttctacg      960

tgaaaagtct gtagaaaagt aagggaaact caaacccctt tcggccagcg tgagtgtttc     1020

tttggcagtg tcttagctgg ttgttgtgag caatagtaag gaagcaatca gcaagtatac     1080

tgccctagaa gtgctgcacg ttgtggggcc cgagacactc ctaatggaat gccgttatcc     1140

aaagagcagc acgaacccga cagggctgag tggcttgtgc tagggagagg tttgtgtcat     1200

tcctgctgac caaactgcag gaaaaactgc taattgtcat gctgaagact gcctgacggg     1260

gagactctgc cttctgtaag taggtcatgt aaagagcacg tgctccttgc tgct           1314


<210>  5
<211>  797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5
cttttcaatt tgaagagagt gcttcctctg ttcttaaggc tagggaacca aattaggttg       60

tttcaatatc gtggacggcg ctaggatcaa ctcaacatca gtcaatgtga taagctacaa      120

gtattctggt cacagaatac aactcaacat cagtcaatgt gataagctac aagatgatcc      180

tagcgccgtc ttgtcggcag tgggaagggg ggccgataca ctgtacgaga gtgagtagca      240

ggtctcacag tgaaccggtc tctttcccta ctgccgacag ctgcctcggg aagccaagtt      300

gggctttaaa gtgcagggcc tgctgatgtt gagtgctttt tgttggcctc tctctccgtg      360

ttcacagcgg accttgattt aaatgtccat acaattaagg cacgcggtga atgccaagaa      420

tggggctggc ataagaagtt atgtattcat ccaataattc aagccaagca agtatatagg      480

tgttttaata gtttttgttt gcactgactc tcttcggtga cgggtattct tgggtggata      540

atacggatta cgttgttatt gcttaagaat acgcgtagtc gaggagagta ccagtgcaca      600

ctcctaatgg aatgccgtta tccaaagagc agcacgaacc cgacagggct gagtggcttg      660

tgctagggag aggtttgtgt cattcctgct gaccaaactg caggaaaaac tgctaattgt      720

catgctgaag actgcctgac ggggagactc tgccttctgt aagtaggtca tgtaaagagc      780

acgtgctcct tgctgct                                                     797


<210>  6
<211>  811
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6
cttttcaatt tgaagagagt gcttcctctg ttcttaaggc tagggaacca aattaggttg       60

tttcaatatc gtggacggcg ctaggatcaa ctcaacatca gtcaatgtga taagctacaa      120

gtattctggt cacagaatac aactcaacat cagtcaatgt gataagctac aagatgatcc      180

tagcgccgtc tttcttatgt ctcgggatat cccagggggg ccgatacact gtacgagagt      240

gagtagcagg tctcacagtg aaccggtctc tttctgggat atcctcgaga cataagaaac      300

aagatagatc ctgaaactgt tttaaggttg gccgatcttc tgctcgagaa tgcatgaagc      360

gttccatatt ttttccgtgt tcacagcgga ccttgattta aatgtccata caattaaggc      420

acgcggtgaa tgccaagaat aatatggaac gcttatgtat tcatccaata attcaagcca      480

agcaagtata taggtgtttt aatagttttt gtttgcactg actctcttcg gtgacgggta      540

ttcttgggtg gataatacgg attacgttgt tattgcttaa gaatacgcgt agtcgaggag      600

agtaccagtg cacactccta atggaatgcc gttatccaaa gagcagcacg aacccgacag      660

ggctgagtgg cttgtgctag ggagaggttt gtgtcattcc tgctgaccaa actgcaggaa      720

aaactgctaa ttgtcatgct gaagactgcc tgacggggag actctgcctt ctgtaagtag      780

gtcatgtaaa gagcacgtgc tccttgctgc t                                     811


<210>  7
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
cagtgggaag gggggccgat acactgtacg agagtgagta gcaggtctca cagtgaaccg       60

gtctctttcc ctactg                                                       76


<210>  8
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
ggcctctctc tccgtgttca cagcggacct tgatttaaat gtccatacaa ttaaggcacg       60

cggtgaatgc caagaatggg gct                                               83


<210>  9
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
ctgactctct tcggtgacgg gtattcttgg gtggataata cggattacgt tgttattgct       60

taagaatacg cgtagtcgag gagagtacca g                                      91


<210>  10
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
gtggaccggc tggccccatc tggaagacta gtgattttgt tgttgtctta ctgcgctcaa       60

caacaaatcc cagtctacct aatggtgcca gccatcgc                               98


<210>  11
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
gtgataatgt agcgagattt tctgttgtgc ttgatctaac catgtggttg cgaggtatga       60

gtaaaacatg gttccgtcaa gcaccatgga acgtcacgca gctttctac                  109


<210>  12
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
ggccagcgtg agtgtttctt tggcagtgtc ttagctggtt gttgtgagca atagtaagga       60

agcaatcagc aagtatactg ccctagaagt gctgcacgtt gtggggccc                  109


<210>  13
<211>  194
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
cttttcaatt tgaagagagt gcttcctctg ttcttaaggg gctagggaac caaattaggt       60

tgtttcaata tcgtgctaaa agatactgcc tttagaagaa ggctattgac aatccagcgt      120

gtctcggtgg aactctgact ccatggttca ctttcatgat ggccacatgc ctcctgccca      180

gagcccggca gcca                                                        194


<210>  14
<211>  192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
cttttcaatt tgaagagagt gcttcctctg ttcttaaggc tagggaacca aattaggttg       60

tttcaatatc gtggacggcg ctaggatcaa ctcaacatca gtcaatgtga taagctacaa      120

gtattctggt cacagaatac aactcaacat cagtcaatgt gataagctac aagatgatcc      180

tagcgccgtc tt                                                          192


<210>  15
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
acactcctaa tggaatgccg ttatccaaag agcagcacga acccgacagg gctgagtggc       60

ttgtgctagg gagaggtttg tgtcattcct gctgaccaaa ctgcaggaaa aactgctaat      120

tgtcatgctg aagactgcct gacggggaga ctctgccttc tgtaagtagg tcatgtaaag      180

agcacgtgct ccttgctgct                                                  200


<210>  16
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
agctgcctcg ggaagccaag ttgggcttta aagtgcaggg cctgctgatg ttgagtgctt       60

tt                                                                      62


<210>  17
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
taagaagtta tgtattcatc caataattca agccaagcaa gtatataggt gttttaatag       60

tttttgttt                                                               69


<210>  18
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
tatttccttc aaatgaatga tttttactaa ttttgtgtac ttttattgtg tcgatgtaga       60

atctgcctgg tctatctgat gtgacagctt ct                                     92


<210>  19
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19
tagctgtaga actccagctt cggcctgtcg cccaatcaaa ctgtcctgtt actgaa           56


<210>  20
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
aaaagtctgt agaaaagtaa gggaaactca aacccct                                37


<210>  21
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21
gggatatcct cgagacataa gaaacaagat agatcctgaa actgttttaa ggttggccga       60

tcttctgctc gagaatgcat gaagcgttcc atattttt                               98


