                               SEQUENCE LISTING

<110> AMICUS THERAPEUTICS, INC.
 
<120> GENE THERAPY CONSTRUCTS AND METHODS OF USE

<130> 36003-701.601

<140> PCT/US2019/030076
<141> 2019-04-30

<150> 62/744,068
<151> 2018-10-10

<150> 62/688,640
<151> 2018-06-22

<150> 62/664,741
<151> 2018-04-30

<160> 48    

<170> PatentIn version 3.5

<210> 1
<211> 67
<212> PRT
<213> Homo sapiens

<400> 1
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 2
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Ser Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 3
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 4
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 5
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Thr 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 6
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Ser Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 7
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ile Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 8
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Arg Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 9
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Arg Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 10
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Ser Leu Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Leu Glu Glu Cys Cys Thr 
        35                  40                  45              


Ser Ile Cys Asp Leu Arg Arg Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 11
<211> 61
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly 
1               5                   10                  15      


Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg 
            20                  25                  30          


Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala 
        35                  40                  45              


Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60      


<210> 12
<211> 190
<212> DNA
<213> Cripavirus sp.

<400> 12
aaaaatgtga tcttgcttgt aaatacaatt ttgagaggtt aataaattac aagtagtgct       60

atttttgtat ttaggttagc tatttagctt tacgttccag gatgcctagt ggcagcccca      120

caatatccag gaagccctct ctgcggtttt tcagattagg tagtcgaaaa acctaagaaa      180

tttacctgct                                                             190


<210> 13
<211> 18
<212> PRT
<213> Homo sapiens

<400> 13
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala 
        


<210> 14
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Leu Val 
1               5                   10                  15      


Ala Ala Met Leu Leu Leu Leu Ser Ala Ala Arg Ala 
            20                  25              


<210> 15
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Trp Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ala Arg Ala 
            20                  25  


<210> 16
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Leu Val 
1               5                   10                  15      


Ala Leu Leu Leu Leu Ser Ala Ala Arg Ala 
            20                  25      


<210> 17
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 17
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Ala Leu Leu Leu Leu Ser Ala Ala Arg Ala 
            20                  25      


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   


<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Gly Gly Gly Gly Ser 
1               5   


<210> 20
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210> 22
<211> 952
<212> PRT
<213> Homo sapiens

<400> 22
Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210> 23
<211> 982
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln 
            20                  25                  30          


Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg 
        35                  40                  45              


Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser 
    50                  55                  60                  


Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser 
65                  70                  75                  80  


Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Gly Pro Arg 
                85                  90                  95      


Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys 
            100                 105                 110         


Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile 
        115                 120                 125             


Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys 
    130                 135                 140                 


Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro 
145                 150                 155                 160 


Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met 
                165                 170                 175     


Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys 
            180                 185                 190         


Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg 
        195                 200                 205             


Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro 
    210                 215                 220                 


Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser 
225                 230                 235                 240 


Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu 
                245                 250                 255     


Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala 
            260                 265                 270         


Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr 
        275                 280                 285             


Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr 
    290                 295                 300                 


Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn 
305                 310                 315                 320 


Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser 
                325                 330                 335     


Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu 
            340                 345                 350         


Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp 
        355                 360                 365             


Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr 
    370                 375                 380                 


Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly 
385                 390                 395                 400 


Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln 
                405                 410                 415     


Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp 
            420                 425                 430         


Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys 
        435                 440                 445             


Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly 
    450                 455                 460                 


Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly 
465                 470                 475                 480 


Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val 
                485                 490                 495     


Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro 
            500                 505                 510         


Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp 
        515                 520                 525             


Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly 
    530                 535                 540                 


Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu 
545                 550                 555                 560 


Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly 
                565                 570                 575     


Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His 
            580                 585                 590         


Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr 
        595                 600                 605             


Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg 
    610                 615                 620                 


Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala 
625                 630                 635                 640 


Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser 
                645                 650                 655     


Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val 
            660                 665                 670         


Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys 
        675                 680                 685             


Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His 
    690                 695                 700                 


Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro 
705                 710                 715                 720 


Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu 
                725                 730                 735     


Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr 
            740                 745                 750         


Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp 
        755                 760                 765             


Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro 
    770                 775                 780                 


Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly 
785                 790                 795                 800 


Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu 
                805                 810                 815     


Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly 
            820                 825                 830         


Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu 
        835                 840                 845             


Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr 
    850                 855                 860                 


Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly 
865                 870                 875                 880 


Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu 
                885                 890                 895     


Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn 
            900                 905                 910         


Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly 
        915                 920                 925             


Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln 
    930                 935                 940                 


Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro 
945                 950                 955                 960 


Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln 
                965                 970                 975     


Phe Leu Val Ser Trp Cys 
            980         


<210> 24
<211> 306
<212> PRT
<213> Homo sapiens

<400> 24
Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly 
305     


<210> 25
<211> 387
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Ser Arg Thr Leu Cys 
            20                  25                  30          


Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly 
        35                  40                  45              


Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg Gly 
    50                  55                  60                  


Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu 
65                  70                  75                  80  


Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Arg Pro Arg Ala Val Pro Thr Gln Asp Pro Pro Ala 
            100                 105                 110         


Pro Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn 
        115                 120                 125             


Pro Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro 
    130                 135                 140                 


Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp 
145                 150                 155                 160 


Val Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val 
                165                 170                 175     


Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala 
            180                 185                 190         


Met Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg 
        195                 200                 205             


Cys Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His 
    210                 215                 220                 


Gln Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile 
225                 230                 235                 240 


Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val 
                245                 250                 255     


Val Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys 
            260                 265                 270         


Glu Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln 
        275                 280                 285             


Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys 
    290                 295                 300                 


Lys Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val 
305                 310                 315                 320 


Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr 
                325                 330                 335     


Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu 
            340                 345                 350         


Lys Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly 
        355                 360                 365             


Asp His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro 
    370                 375                 380                 


Phe Leu Gly 
385         


<210> 26
<211> 387
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Trp Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ala Arg Ala Ala Ala Ser Arg Thr Leu Cys 
            20                  25                  30          


Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly 
        35                  40                  45              


Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg Gly 
    50                  55                  60                  


Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu 
65                  70                  75                  80  


Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Arg Pro Arg Ala Val Pro Thr Gln Asp Pro Pro Ala 
            100                 105                 110         


Pro Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn 
        115                 120                 125             


Pro Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro 
    130                 135                 140                 


Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp 
145                 150                 155                 160 


Val Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val 
                165                 170                 175     


Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala 
            180                 185                 190         


Met Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg 
        195                 200                 205             


Cys Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His 
    210                 215                 220                 


Gln Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile 
225                 230                 235                 240 


Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val 
                245                 250                 255     


Val Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys 
            260                 265                 270         


Glu Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln 
        275                 280                 285             


Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys 
    290                 295                 300                 


Lys Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val 
305                 310                 315                 320 


Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr 
                325                 330                 335     


Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu 
            340                 345                 350         


Lys Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly 
        355                 360                 365             


Asp His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro 
    370                 375                 380                 


Phe Leu Gly 
385         


<210> 27
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 27
gccrccatgg                                                              10


<210> 28
<211> 7
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (2)..(3)
<223> a, c, t, g, unknown or other

<400> 28
annatga                                                                  7


<210> 29
<211> 7
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 29
aagatga                                                                  7


<210> 30
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp 
1               5                   10                  15      


Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser 
            20                  25                  30          


Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu 
        35                  40                  45              


Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60  


<210> 31
<211> 63
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210> 32
<211> 17
<212> PRT
<213> Gaussia princeps

<400> 32
Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Gly Gly Ser Gly Ser Gly Ser Thr Ser 
1               5                   


<210> 34
<211> 63
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu 
    50                  55                  60              


<210> 35
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Ala Tyr Arg Pro Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 36
<211> 189
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 36
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210> 37
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 38
<211> 2954
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (869)..(869)
<223> a, c, t, g, unknown or other

<400> 38
gcaagatgaa gctctccctg gtggccgcga tgctgctgct gctcagcgcg gcgcgggcct       60

ctagaacact gtgcggaggg gagcttgtag acactcttca gttcgtgtgt ggagatcgcg      120

ggttcctctt ctctcgcccc gcttccagag tttcacggag gtctaggggt atagtagagg      180

agtgttgttt caggtcctgt gacttggcgc tcctcgagac ctattgcgcg acgccagcca      240

ggtccgaagg gggcggtggc tcaggtggtg gaggtagcag accagggccc cgggatgccc      300

aggcacaccc cggccgtccc agagcagtgc ccacacagtg cgacgtcccc cccaacagcc      360

gcttcgattg cgcccctgac aaggccatca cccaggaaca gtgcgaggcc cgcggctgtt      420

gctacatccc tgcaaagcag gggctgcagg gagcccagat ggggcagccc tggtgcttct      480

tcccacccag ctaccccagc tacaagctgg agaacctgag ctcctctgaa atgggctaca      540

cggccaccct gacccgtacc acccccacct tcttccccaa ggacatcctg accctgcggc      600

tggacgtgat gatggagact gagaaccgcc tccacttcac gatcaaagat ccagctaaca      660

ggcgctacga ggtgcccttg gagaccccgc atgtccacag ccgggcaccg tccccactct      720

acagcgtgga gttctccgag gagcccttcg gggtgatcgt gcgccggcag ctggacggcc      780

gcgtgctgct gaacacgacg gtggcgcccc tgttctttgc ggaccagttc cttcagctgt      840

ccacctcgct gccctcgcag tatatcacng gcctcgccga gcacctcagt cccctgatgc      900

tcagcaccag ctggaccagg atcaccctgt ggaaccggga ccttgcgccc acgcccggtg      960

cgaacctcta cgggtctcac cctttctacc tggcgctgga ggacggcggg tcggcacacg     1020

gggtgttcct gctaaacagc aatgccatgg atgtggtcct gcagccgagc cctgccctta     1080

gctggaggtc gacaggtggg atcctggatg tctacatctt cctgggccca gagcccaaga     1140

gcgtggtgca gcagtacctg gacgttgtgg gatacccgtt catgccgcca tactggggcc     1200

tgggcttcca cctgtgccgc tggggctact cctccaccgc tatcacccgc caggtggtgg     1260

agaacatgac cagggcccac ttccccctgg acgtccagtg gaacgacctg gactacatgg     1320

actcccggag ggacttcacg ttcaacaagg atggcttccg ggacttcccg gccatggtgc     1380

aggagctgca ccagggcggc cggcgctaca tgatgatcgt ggatcctgcc atcagcagct     1440

cgggccctgc cgggagctac aggccctacg acgagggtct gcggaggggg gttttcatca     1500

ccaacgagac cggccagccg ctgattggga aggtatggcc cgggtccact gccttccccg     1560

acttcaccaa ccccacagcc ctggcctggt gggaggacat ggtggctgag ttccatgacc     1620

aggtgccctt cgacggcatg tggattgaca tgaacgagcc ttccaacttc atcaggggct     1680

ctgaggacgg ctgccccaac aatgagctgg agaacccacc ctacgtgcct ggggtggttg     1740

gggggaccct ccaggcggcc accatctgtg cctccagcca ccagtttctc tccacacact     1800

acaacctgca caacctctac ggcctgaccg aagccatcgc ctcccacagg gcgctggtga     1860

aggctcgggg gacacgccca tttgtgatct cccgctcgac ctttgctggc cacggccgat     1920

acgccggcca ctggacgggg gacgtgtgga gctcctggga gcagctcgcc tcctccgtgc     1980

cagaaatcct gcagtttaac ctgctggggg tgcctctggt cggggccgac gtctgcggct     2040

tcctgggcaa cacctcagag gagctgtgtg tgcgctggac ccagctgggg gccttctacc     2100

ccttcatgcg gaaccacaac agcctgctca gtctgcccca ggagccgtac agcttcagcg     2160

agccggccca gcaggccatg aggaaggccc tcaccctgcg ctacgcactc ctcccccacc     2220

tctacacact gttccaccag gcccacgtcg cgggggagac cgtggcccgg cccctcttcc     2280

tggagttccc caaggactct agcacctgga ctgtggacca ccagctcctg tggggggagg     2340

ccctgctcat caccccagtg ctccaggccg ggaaggccga agtgactggc tacttcccct     2400

tgggcacatg gtacgacctg cagacggtgc cagtagaggc ccttggcagc ctcccacccc     2460

cacctgcagc tccccgtgag ccagccatcc acagcgaggg gcagtgggtg acgctgccgg     2520

cccccctgga caccatcaac gtccacctcc gggctgggta catcatcccc ctgcagggcc     2580

ctggcctcac aaccacagag tcccgccagc agcccatggc cctggctgtg gccctgacca     2640

agggtgggga ggcccgaggg gagctgttct gggacgatgg agagagcctg gaagtgctgg     2700

agcgaggggc ctacacacag gtcatcttcc tggccaggaa taacacgatc gtgaatgagc     2760

tggtacgtgt gaccagtgag ggagctggcc tgcagctgca gaaggtgact gtcctgggcg     2820

tggccacggc gccccagcag gtcctctcca acggtgtccc tgtctccaac ttcacctaca     2880

gccccgacac caaggtcctg gacatctgtg tctcgctgtt gatgggagag cagtttctcg     2940

tcagctggtg ttag                                                       2954


<210> 39
<211> 3139
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 39
aaaaatgtga tcttgcttgt aaatacaatt ttgagaggtt aataaattac aagtagtgct       60

atttttgtat ttaggttagc tatttagctt tacgttccag gatgcctagt ggcagcccca      120

caatatccag gaagccctct ctgcggtttt tcagattagg tagtcgaaaa acctaagaaa      180

tttacctgct atgaagctct ccctggtggc cgcgatgctg ctgctgctca gcgcggcgcg      240

ggcctctaga acactgtgcg gaggggagct tgtagacact cttcagttcg tgtgtggaga      300

tcgcgggttc ctcttctctc gccccgcttc cagagtttca cggaggtcta ggggtatagt      360

agaggagtgt tgtttcaggt cctgtgactt ggcgctcctc gagacctatt gcgcgacgcc      420

agccaggtcc gaagggggcg gtggctcagg tggtggaggt agcagaccag ggccccggga      480

tgcccaggca caccccggcc gtcccagagc agtgcccaca cagtgcgacg tcccccccaa      540

cagccgcttc gattgcgccc ctgacaaggc catcacccag gaacagtgcg aggcccgcgg      600

ctgttgctac atccctgcaa agcaggggct gcagggagcc cagatggggc agccctggtg      660

cttcttccca cccagctacc ccagctacaa gctggagaac ctgagctcct ctgaaatggg      720

ctacacggcc accctgaccc gtaccacccc caccttcttc cccaaggaca tcctgaccct      780

gcggctggac gtgatgatgg agactgagaa ccgcctccac ttcacgatca aagatccagc      840

taacaggcgc tacgaggtgc ccttggagac cccgcatgtc cacagccggg caccgtcccc      900

actctacagc gtggagttct ccgaggagcc cttcggggtg atcgtgcgcc ggcagctgga      960

cggccgcgtg ctgctgaaca cgacggtggc gcccctgttc tttgcggacc agttccttca     1020

gctgtccacc tcgctgccct cgcagtatat cacaggcctc gccgagcacc tcagtcccct     1080

gatgctcagc accagctgga ccaggatcac cctgtggaac cgggaccttg cgcccacgcc     1140

cggtgcgaac ctctacgggt ctcacccttt ctacctggcg ctggaggacg gcgggtcggc     1200

acacggggtg ttcctgctaa acagcaatgc catggatgtg gtcctgcagc cgagccctgc     1260

ccttagctgg aggtcgacag gtgggatcct ggatgtctac atcttcctgg gcccagagcc     1320

caagagcgtg gtgcagcagt acctggacgt tgtgggatac ccgttcatgc cgccatactg     1380

gggcctgggc ttccacctgt gccgctgggg ctactcctcc accgctatca cccgccaggt     1440

ggtggagaac atgaccaggg cccacttccc cctggacgtc cagtggaacg acctggacta     1500

catggactcc cggagggact tcacgttcaa caaggatggc ttccgggact tcccggccat     1560

ggtgcaggag ctgcaccagg gcggccggcg ctacatgatg atcgtggatc ctgccatcag     1620

cagctcgggc cctgccggga gctacaggcc ctacgacgag ggtctgcgga ggggggtttt     1680

catcaccaac gagaccggcc agccgctgat tgggaaggta tggcccgggt ccactgcctt     1740

ccccgacttc accaacccca cagccctggc ctggtgggag gacatggtgg ctgagttcca     1800

tgaccaggtg cccttcgacg gcatgtggat tgacatgaac gagccttcca acttcatcag     1860

gggctctgag gacggctgcc ccaacaatga gctggagaac ccaccctacg tgcctggggt     1920

ggttgggggg accctccagg cggccaccat ctgtgcctcc agccaccagt ttctctccac     1980

acactacaac ctgcacaacc tctacggcct gaccgaagcc atcgcctccc acagggcgct     2040

ggtgaaggct cgggggacac gcccatttgt gatctcccgc tcgacctttg ctggccacgg     2100

ccgatacgcc ggccactgga cgggggacgt gtggagctcc tgggagcagc tcgcctcctc     2160

cgtgccagaa atcctgcagt ttaacctgct gggggtgcct ctggtcgggg ccgacgtctg     2220

cggcttcctg ggcaacacct cagaggagct gtgtgtgcgc tggacccagc tgggggcctt     2280

ctaccccttc atgcggaacc acaacagcct gctcagtctg ccccaggagc cgtacagctt     2340

cagcgagccg gcccagcagg ccatgaggaa ggccctcacc ctgcgctacg cactcctccc     2400

ccacctctac acactgttcc accaggccca cgtcgcgggg gagaccgtgg cccggcccct     2460

cttcctggag ttccccaagg actctagcac ctggactgtg gaccaccagc tcctgtgggg     2520

ggaggccctg ctcatcaccc cagtgctcca ggccgggaag gccgaagtga ctggctactt     2580

ccccttgggc acatggtacg acctgcagac ggtgccagta gaggcccttg gcagcctccc     2640

acccccacct gcagctcccc gtgagccagc catccacagc gaggggcagt gggtgacgct     2700

gccggccccc ctggacacca tcaacgtcca cctccgggct gggtacatca tccccctgca     2760

gggccctggc ctcacaacca cagagtcccg ccagcagccc atggccctgg ctgtggccct     2820

gaccaagggt ggggaggccc gaggggagct gttctgggac gatggagaga gcctggaagt     2880

gctggagcga ggggcctaca cacaggtcat cttcctggcc aggaataaca cgatcgtgaa     2940

tgagctggta cgtgtgacca gtgagggagc tggcctgcag ctgcagaagg tgactgtcct     3000

gggcgtggcc acggcgcccc agcaggtcct ctccaacggt gtccctgtct ccaacttcac     3060

ctacagcccc gacaccaagg tcctggacat ctgtgtctcg ctgttgatgg gagagcagtt     3120

tctcgtcagc tggtgttag                                                  3139


<210> 40
<211> 921
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 40
atggcatcac cgggttgcct ctggttgttg gccgttgcgt tgcttccgtg gacatgtgca       60

tcaagagctc ttcaacatct ggatccccca gctcccctgc cgctcgtaat ctggcacggg      120

atgggggatt catgttgtaa cccgttgtca atgggcgcga taaaaaagat ggttgaaaag      180

aagattccag gcatctacgt tctgtccctg gaaatcggta agacactgat ggaagacgtg      240

gagaactcct tctttctcaa cgtcaatagt caggtcacta ccgtctgtca agcattggca      300

aaggacccta aacttcagca ggggtacaat gcgatggggt ttagccaggg cggacagttt      360

cttagagccg tcgcacagcg ctgtccatct cccccgatga ttaaccttat atctgtcggg      420

ggacaacacc agggtgtttt tggtcttcct cgctgtcctg gtgaaagctc ccacatctgt      480

gatttcatac gcaaaacgtt gaacgcagga gcttatagta aagtcgtcca agaacggctt      540

gttcaagcgg agtattggca tgacccaata aaagaagacg tttataggaa tcactctatc      600

ttcttggccg atatcaacca agaacgcgga atcaacgaaa gctacaaaaa gaatcttatg      660

gctctcaaga aatttgttat ggtgaaattc cttaatgact ctatagtaga tcctgtcgat      720

tcagaatggt tcgggttcta caggtctggc caggcgaagg agactattcc cctccaagaa      780

acgtctctct atacacaaga cagactcgga ctgaaagaga tggataatgc gggccagttg      840

gtcttcttgg ctacggaagg cgatcatctc caactctccg aagagtggtt ctatgcccat      900

ataatcccgt tcctgggcta a                                                921


<210> 41
<211> 1164
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 41
atggcatccc ccggatgttt gtggctgctg gcggttgcgc ttctgccatg gacgtgcgcc       60

tcccgagccc tccaacacct gtccaggaca ctttgcggcg gagagttggt cgatacgctt      120

caattcgtgt gtggggatag aggcttcctt ttttctcggc ccgctagccg cgtgtcccga      180

aggtcccggg gtatcgttga ggaatgctgt ttccggtcct gcgatcttgc actgttggag      240

acatactgtg ctacgcctgc gagaagcgag ggtggagggg gttctggagg tggagggagc      300

cggcctcggg cggttcccac ccaggatcct ccagctcctc tgcctctggt catctggcat      360

gggatggggg actcatgttg taacccgctg agtatggggg caattaaaaa aatggttgaa      420

aagaaaattc caggtattta tgtcctctct cttgaaatcg gtaagacact tatggaggat      480

gtggaaaact cctttttcct taatgtcaat tctcaggtca caacagtttg tcaggctctg      540

gcgaaggatc ctaagctgca gcaaggctac aacgccatgg gtttttccca gggaggccaa      600

tttctcagag cggtagctca gcgatgtcca tcaccaccga tgataaatct gatcagtgtc      660

ggcggacaac accagggagt tttcgggctg cccaggtgtc cgggggaatc tagtcacata      720

tgtgacttca ttcgcaagac ccttaacgcc ggcgcttact caaaggtggt tcaagaacgg      780

cttgtgcagg ctgaatactg gcacgatccc atcaaggaag atgtatatag gaaccacagt      840

atctttctgg cagacataaa tcaggaaagg ggtattaacg aaagctacaa gaaaaatctc      900

atggccctga agaaatttgt aatggttaag tttttgaacg attctatagt agatcctgtt      960

gactccgagt ggttcgggtt ctatcgatct ggtcaagcca aggagacgat tccgcttcag     1020

gaaacttcac tgtacacaca ggatcggctg ggactcaagg agatggacaa tgcgggccag     1080

ttggtgtttc tggctacaga gggagaccat ctccagttga gtgaagaatg gttctatgca     1140

catattatcc cattcctcgg ctaa                                            1164


<210> 42
<211> 1164
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 42
atgaagctct ccctggtggc cgcgatgctg ctgctgctct gggtggcact gctgctgctc       60

agcgcggcga gggccgccgc gagtcgcacg ttgtgtggag gtgaactcgt cgacaccctt      120

cagttcgtat gtggagatcg cggtttcctc ttctcacgcc cagcttccag agtttcccga      180

agatcacgag gaatagttga ggagtgctgt tttcggtctt gtgatctggc tctcctcgag      240

acttattgtg ctacgccggc ccgctctgaa ggaggtggtg gcagtggagg aggagggagt      300

cggcctaggg cagtcccaac ccaggacccg ccggcgccgc tgccgttggt gatctggcat      360

gggatgggag acagctgttg caatccctta agcatgggtg ctattaaaaa aatggtggag      420

aagaaaatac ctggaattta cgtcttatct ttagagattg ggaagaccct gatggaggac      480

gtggagaaca gcttcttctt gaatgtcaat tcccaagtaa caacagtgtg tcaggcactt      540

gctaaggatc ctaaattgca gcaaggctac aatgctatgg gattctccca gggaggccaa      600

tttctgaggg cagtggctca gagatgccct tcacctccca tgatcaatct gatctcggtt      660

gggggacaac atcaaggtgt ttttggactc cctcgatgcc caggagagag ctctcacatc      720

tgtgacttca tccgaaaaac actgaatgct ggggcgtact ccaaagttgt tcaggaacgc      780

ctcgtgcaag ccgaatactg gcatgacccc ataaaggagg atgtgtatcg caaccacagc      840

atcttcttgg cagatataaa tcaggagcgg ggtatcaatg agtcctacaa gaaaaacctg      900

atggccctga agaagtttgt gatggtgaaa ttcctcaatg attccattgt ggaccctgta      960

gattcggagt ggtttggatt ttacagaagt ggccaagcca aggaaaccat tcccttacag     1020

gagacctccc tgtacacaca ggaccgcctg gggctaaagg aaatggacaa tgcaggacag     1080

ctagtgtttc tggctacaga aggggaccat cttcagttgt ctgaagaatg gttttatgcc     1140

cacatcatac cattccttgg atga                                            1164


<210> 43
<211> 72
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 43
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr Leu Cys Gly Gly 
1               5                   10                  15      


Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu 
            20                  25                  30          


Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val 
        35                  40                  45              


Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr 
    50                  55                  60                  


Cys Ala Thr Pro Ala Arg Ser Glu 
65                  70          


<210> 44
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 44
gcaagatg                                                                 8


<210> 45
<211> 2864
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 45
gcaagatggg agtgaggcac ccgccctgct cccaccggct cctggccgtc tgcgccctcg       60

tgtccttggc aaccgctgca ctcctggggc acatcctact ccatgatttc ctgctggttc      120

cccgagagct gagtggctcc tccccagtcc tggaggagac tcacccagct caccagcagg      180

gagccagtag accagggccc cgggatgccc aggcacaccc cggccgtccc agagcagtgc      240

ccacacagtg cgacgtcccc cccaacagcc gcttcgattg cgcccctgac aaggccatca      300

cccaggaaca gtgcgaggcc cgcggctgtt gctacatccc tgcaaagcag gggctgcagg      360

gagcccagat ggggcagccc tggtgcttct tcccacccag ctaccccagc tacaagctgg      420

agaacctgag ctcctctgaa atgggctaca cggccaccct gacccgtacc acccccacct      480

tcttccccaa ggacatcctg accctgcggc tggacgtgat gatggagact gagaaccgcc      540

tccacttcac gatcaaagat ccagctaaca ggcgctacga ggtgcccttg gagaccccgc      600

atgtccacag ccgggcaccg tccccactct acagcgtgga gttctccgag gagcccttcg      660

gggtgatcgt gcgccggcag ctggacggcc gcgtgctgct gaacacgacg gtggcgcccc      720

tgttctttgc ggaccagttc cttcagctgt ccacctcgct gccctcgcag tatatcacag      780

gcctcgccga gcacctcagt cccctgatgc tcagcaccag ctggaccagg atcaccctgt      840

ggaaccggga ccttgcgccc acgcccggtg cgaacctcta cgggtctcac cctttctacc      900

tggcgctgga ggacggcggg tcggcacacg gggtgttcct gctaaacagc aatgccatgg      960

atgtggtcct gcagccgagc cctgccctta gctggaggtc gacaggtggg atcctggatg     1020

tctacatctt cctgggccca gagcccaaga gcgtggtgca gcagtacctg gacgttgtgg     1080

gatacccgtt catgccgcca tactggggcc tgggcttcca cctgtgccgc tggggctact     1140

cctccaccgc tatcacccgc caggtggtgg agaacatgac cagggcccac ttccccctgg     1200

acgtccagtg gaacgacctg gactacatgg actcccggag ggacttcacg ttcaacaagg     1260

atggcttccg ggacttcccg gccatggtgc aggagctgca ccagggcggc cggcgctaca     1320

tgatgatcgt ggatcctgcc atcagcagct cgggccctgc cgggagctac aggccctacg     1380

acgagggtct gcggaggggg gttttcatca ccaacgagac cggccagccg ctgattggga     1440

aggtatggcc cgggtccact gccttccccg acttcaccaa ccccacagcc ctggcctggt     1500

gggaggacat ggtggctgag ttccatgacc aggtgccctt cgacggcatg tggattgaca     1560

tgaacgagcc ttccaacttc atcaggggct ctgaggacgg ctgccccaac aatgagctgg     1620

agaacccacc ctacgtgcct ggggtggttg gggggaccct ccaggcggcc accatctgtg     1680

cctccagcca ccagtttctc tccacacact acaacctgca caacctctac ggcctgaccg     1740

aagccatcgc ctcccacagg gcgctggtga aggctcgggg gacacgccca tttgtgatct     1800

cccgctcgac ctttgctggc cacggccgat acgccggcca ctggacgggg gacgtgtgga     1860

gctcctggga gcagctcgcc tcctccgtgc cagaaatcct gcagtttaac ctgctggggg     1920

tgcctctggt cggggccgac gtctgcggct tcctgggcaa cacctcagag gagctgtgtg     1980

tgcgctggac ccagctgggg gccttctacc ccttcatgcg gaaccacaac agcctgctca     2040

gtctgcccca ggagccgtac agcttcagcg agccggccca gcaggccatg aggaaggccc     2100

tcaccctgcg ctacgcactc ctcccccacc tctacacact gttccaccag gcccacgtcg     2160

cgggggagac cgtggcccgg cccctcttcc tggagttccc caaggactct agcacctgga     2220

ctgtggacca ccagctcctg tggggggagg ccctgctcat caccccagtg ctccaggccg     2280

ggaaggccga agtgactggc tacttcccct tgggcacatg gtacgacctg cagacggtgc     2340

cagtagaggc ccttggcagc ctcccacccc cacctgcagc tccccgtgag ccagccatcc     2400

acagcgaggg gcagtgggtg acgctgccgg cccccctgga caccatcaac gtccacctcc     2460

gggctgggta catcatcccc ctgcagggcc ctggcctcac aaccacagag tcccgccagc     2520

agcccatggc cctggctgtg gccctgacca agggtgggga ggcccgaggg gagcttttct     2580

gggacgatgg agagagcctg gaagtgctgg agcgaggggc ctacacacag gtcatcttcc     2640

tggccaggaa taacacgatc gtgaatgagc tggtacgtgt gaccagtgag ggagctggcc     2700

tgcagctgca gaaggtgact gtcctgggcg tggccacggc gccccagcag gtcctctcca     2760

acggtgtccc tgtctccaac ttcacctaca gccccgacac caaggtcctg gacatctgtg     2820

tctcgctgtt gatgggagag cagtttctcg tcagctggtg ttag                      2864


<210> 46
<211> 892
<212> PRT
<213> Homo sapiens

<400> 46
Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg 
1               5                   10                  15      


Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys 
            20                  25                  30          


Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys 
        35                  40                  45              


Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln 
    50                  55                  60                  


Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn 
65                  70                  75                  80  


Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr 
                85                  90                  95      


Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met 
            100                 105                 110         


Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn 
        115                 120                 125             


Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala 
    130                 135                 140                 


Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val 
145                 150                 155                 160 


Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val 
                165                 170                 175     


Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu 
            180                 185                 190         


Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met 
        195                 200                 205             


Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala 
    210                 215                 220                 


Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala 
225                 230                 235                 240 


Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn 
                245                 250                 255     


Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser 
            260                 265                 270         


Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys 
        275                 280                 285             


Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro 
    290                 295                 300                 


Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser 
305                 310                 315                 320 


Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe 
                325                 330                 335     


Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg 
            340                 345                 350         


Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val 
        355                 360                 365             


Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro 
    370                 375                 380                 


Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu 
385                 390                 395                 400 


Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu 
                405                 410                 415     


Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn 
            420                 425                 430         


Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp 
        435                 440                 445             


Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn 
    450                 455                 460                 


Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn 
465                 470                 475                 480 


Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr 
                485                 490                 495     


Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His 
            500                 505                 510         


Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val 
        515                 520                 525             


Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala 
    530                 535                 540                 


Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser 
545                 550                 555                 560 


Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu 
                565                 570                 575     


Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn 
            580                 585                 590         


Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr 
        595                 600                 605             


Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro 
    610                 615                 620                 


Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr 
625                 630                 635                 640 


Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala 
                645                 650                 655     


His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro 
            660                 665                 670         


Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu 
        675                 680                 685             


Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr 
    690                 695                 700                 


Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val 
705                 710                 715                 720 


Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro 
                725                 730                 735     


Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp 
            740                 745                 750         


Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly 
        755                 760                 765             


Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala 
    770                 775                 780                 


Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp 
785                 790                 795                 800 


Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val 
                805                 810                 815     


Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val 
            820                 825                 830         


Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly 
        835                 840                 845             


Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser 
    850                 855                 860                 


Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser 
865                 870                 875                 880 


Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
                885                 890         


<210> 47
<211> 7
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 47
caccatg                                                                  7


<210> 48
<211> 201
<212> DNA
<213> Homo sapiens

<400> 48
gcttaccgcc ccagtgagac cctgtgcggc ggggagctgg tggacaccct ccagttcgtc       60

tgtggggacc gcggcttcta cttcagcagg cccgcaagcc gtgtgagccg tcgcagccgt      120

ggcatcgttg aggagtgctg tttccgcagc tgtgacctgg ccctcctgga gacgtactgt      180

gctacccccg ccaagtccga g                                                201


