                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> REAGENT TO LABEL PROTEINS VIA LYSINE ISOPEPTIDE BONDS

<130> 30435.0352WOU1

<140> PCT/US2019/030206
<141> 2019-05-01

<150> 62/665,076
<151> 2018-05-01

<160> 41    

<170> PatentIn version 3.5

<210> 1
<211> 221
<212> PRT
<213> Corynebacterium diphtheriae

<400> 1
Asn Asn Ala Arg Gln Ala Arg Val Ala Gln Ser Tyr Glu Asn Ser Tyr 
1               5                   10                  15      


Glu Val Asp Ser Pro Ala Val Arg Asp Ser Val Leu Glu Ala Ala Arg 
            20                  25                  30          


Gln Tyr Asn Thr Ser Val Val Gly Phe Pro Ile Leu Asp Pro Trp Leu 
        35                  40                  45              


Asn Arg Ala Ser Lys Asn Ser Gly Pro Tyr Leu Asp Tyr Leu Gln Gln 
    50                  55                  60                  


Leu Asn Pro Gln Arg Ala Glu Arg Pro Val Ile Ala Ser Ile Ser Ile 
65                  70                  75                  80  


Pro Thr Ile Asp Ala His Leu Pro Ile Tyr His Gly Thr Asp Thr Ala 
                85                  90                  95      


Thr Leu Glu His Gly Leu Gly His Leu Tyr Gly Ser Ala Leu Pro Val 
            100                 105                 110         


Gly Gly Thr Gly Thr His Pro Val Ile Thr Gly His Ser Gly Leu Ala 
        115                 120                 125             


Asn Ala Thr Leu Phe Asp Asn Leu Glu Asp Val Lys Glu His Asp Pro 
    130                 135                 140                 


Ile Tyr Ile Thr Val Gln Gly Glu Thr Leu Lys Tyr Glu Val Asp Ala 
145                 150                 155                 160 


Ile Asn Val Val Leu Pro Glu Asp Thr Lys Leu Leu Ala Pro Asp Pro 
                165                 170                 175     


Asn Lys Asp Gln Ile Thr Leu Ile Thr Cys Thr Pro Tyr Ala Val Asn 
            180                 185                 190         


Ser His Arg Leu Leu Val Arg Ala His Arg Val Asp Leu Asp Pro Asn 
        195                 200                 205             


Asp Pro Asn Leu Thr Gln Thr Gly Thr Lys Ile Trp Gln 
    210                 215                 220     


<210> 2
<211> 206
<212> PRT
<213> Staphylococcus aureus

<400> 2
Met Lys Lys Trp Thr Asn Arg Leu Met Thr Ile Ala Gly Val Val Leu 
1               5                   10                  15      


Ile Leu Val Ala Ala Tyr Leu Phe Ala Lys Pro His Ile Asp Asn Tyr 
            20                  25                  30          


Leu His Asp Lys Asp Lys Asp Glu Lys Ile Glu Gln Tyr Asp Lys Asn 
        35                  40                  45              


Val Lys Glu Gln Ala Ser Lys Asp Lys Lys Gln Gln Ala Lys Pro Gln 
    50                  55                  60                  


Ile Pro Lys Asp Lys Ser Lys Val Ala Gly Tyr Ile Glu Ile Pro Asp 
65                  70                  75                  80  


Ala Asp Ile Lys Glu Pro Val Tyr Pro Gly Pro Ala Thr Pro Glu Gln 
                85                  90                  95      


Leu Asn Arg Gly Val Ser Phe Ala Glu Glu Asn Glu Ser Leu Asp Asp 
            100                 105                 110         


Gln Asn Ile Ser Ile Ala Gly His Thr Phe Ile Asp Arg Pro Asn Tyr 
        115                 120                 125             


Gln Phe Thr Asn Leu Lys Ala Ala Lys Lys Gly Ser Met Val Tyr Phe 
    130                 135                 140                 


Lys Val Gly Asn Glu Thr Arg Lys Tyr Lys Met Thr Ser Ile Arg Asp 
145                 150                 155                 160 


Val Lys Pro Thr Asp Val Gly Val Leu Asp Glu Gln Lys Gly Lys Asp 
                165                 170                 175     


Lys Gln Leu Thr Leu Ile Thr Cys Asp Asp Tyr Asn Glu Lys Thr Gly 
            180                 185                 190         


Val Trp Glu Lys Arg Lys Ile Phe Val Ala Thr Glu Val Lys 
        195                 200                 205     


<210> 3
<211> 436
<212> PRT
<213> Corynebacterium diphtheriae

<400> 3
Gly Pro Glu Arg Thr Ser Ile Ala Val His Ala Leu Met Gly Leu Pro 
1               5                   10                  15      


Thr Gly Gln Pro Ala Asn Gly Thr Lys Leu Asp Ser Ile Gly Leu Pro 
            20                  25                  30          


Lys Val Asp Gly Met Ser Phe Thr Leu Tyr Arg Val Asn Glu Ile Asp 
        35                  40                  45              


Leu Thr Thr Gln Ala Gly Trp Asp Ala Ala Ser Lys Ile Lys Leu Glu 
    50                  55                  60                  


Glu Leu Tyr Thr Asn Gly His Pro Thr Asp Lys Val Thr Lys Val Ala 
65                  70                  75                  80  


Thr Lys Lys Thr Glu Gly Gly Val Ala Lys Phe Asp Asn Leu Thr Pro 
                85                  90                  95      


Ala Leu Tyr Leu Val Val Gln Glu Leu Asn Gly Ala Glu Ala Val Val 
            100                 105                 110         


Arg Ser Gln Pro Phe Leu Val Ala Ala Pro Gln Thr Asn Pro Thr Gly 
        115                 120                 125             


Asp Gly Trp Leu Gln Asp Val His Val Tyr Pro Lys His Gln Ala Leu 
    130                 135                 140                 


Ser Glu Pro Val Lys Thr Ala Val Asp Pro Asp Ala Thr Gln Pro Gly 
145                 150                 155                 160 


Phe Ser Val Gly Glu Asn Val Lys Tyr Arg Val Ala Thr Lys Ile Pro 
                165                 170                 175     


Glu Ile Ala Ser Asn Thr Lys Phe Glu Gly Phe Thr Val Ala Asp Lys 
            180                 185                 190         


Leu Pro Ala Glu Leu Gly Lys Pro Asp Thr Asn Lys Ile Thr Val Thr 
        195                 200                 205             


Leu Gly Gly Lys Pro Ile Asn Ser Thr Asp Val Ser Val Gln Thr Tyr 
    210                 215                 220                 


Gln Val Gly Asp Arg Thr Val Leu Ser Val Gln Leu Ala Gly Ala Thr 
225                 230                 235                 240 


Leu Gln Ser Leu Asp Gln His Lys Asp Gln Glu Leu Val Val Glu Phe 
                245                 250                 255     


Glu Ala Pro Val Thr Lys Gln Pro Glu Asn Gly Gln Leu Asp Asn Gln 
            260                 265                 270         


Ala Trp Val Leu Pro Ser Asn Pro Thr Ala Gln Trp Asp Pro Glu Glu 
        275                 280                 285             


Ser Gly Asp Ala Ala Leu Arg Gly Met Pro Ser Ser Arg Val Ser Ser 
    290                 295                 300                 


Lys Phe Gly Gln Ile Thr Ile Glu Lys Ser Phe Asp Gly Asn Thr Pro 
305                 310                 315                 320 


Gly Ala Asp Arg Thr Ala Thr Phe Gln Leu His Arg Cys Glu Ala Asp 
                325                 330                 335     


Gly Ser Leu Val Lys Ser Asp Pro Pro Ile Ser Leu Asp Gly Lys Gln 
            340                 345                 350         


Glu Phe Val Thr Gly Gln Asp Gly Lys Ala Val Leu Ser Gly Ile His 
        355                 360                 365             


Leu Gly Thr Leu Gln Leu Glu Ser Asn Val Met Lys Tyr Thr Asp Ala 
    370                 375                 380                 


Trp Ala Gly Lys Gly Thr Glu Phe Cys Leu Val Glu Thr Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Tyr Glu Leu Leu Pro Lys Pro Val Ile Val Lys Leu Glu Ala 
                405                 410                 415     


Asn Glu Ser Thr Asn Val Leu Val Glu Gln Lys Val Lys Ile Asp Asn 
            420                 425                 430         


Lys Lys Lys Asn 
        435     


<210> 4
<211> 209
<212> PRT
<213> Corynebacterium diphtheriae

<400> 4
Met Lys Asn Asn Ala Ile Asn Ala Thr Val Leu Ser Phe Ala Leu Ile 
1               5                   10                  15      


Ile Gly Thr Thr Pro Ala His Ala Gln Glu Thr Asn Thr Leu Val Ile 
            20                  25                  30          


Asp Leu Glu Pro Pro Ala Ala Phe Ala Asp Asp Gln Pro Gln Gly His 
        35                  40                  45              


Asn Ile Asp Val Thr Val Thr Arg Leu His Asn Ile Asp Pro Gln Asp 
    50                  55                  60                  


His Glu Arg Ile Arg Asp Leu Gln Arg Asn Gly Val Pro Asn Thr Ile 
65                  70                  75                  80  


Ser Glu Glu Gln Leu His Thr Ala Arg Thr Asp Ala Thr Gly Thr Ala 
                85                  90                  95      


Thr Ile Thr Asn Leu Pro Pro Gly Ala Tyr Val Ile Arg Asp Ser Asn 
            100                 105                 110         


Thr Thr Lys Pro Arg Phe Ser Pro Leu Val Ile Pro Leu Gly Ile Asp 
        115                 120                 125             


Thr Thr Ser Pro Thr Met Thr Leu Arg Pro Lys Leu Ile Asp Val Thr 
    130                 135                 140                 


Pro Gly Ala Pro Asn Val Pro Ser Thr Pro Ser Val Pro Ser Pro Pro 
145                 150                 155                 160 


Ser Ala Thr Ala Ser Ala Pro Ala Lys Lys Thr Pro Pro Arg Leu Ala 
                165                 170                 175     


Phe Thr Gly Ala Ser Ile Leu Gly Leu Leu Ala Ile Ala Thr Ile Ser 
            180                 185                 190         


Thr Leu Ile Gly Ile Ala Leu Ile Arg Thr Arg Arg Ala Glu Asn Lys 
        195                 200                 205             


Gly 
    


<210> 5
<211> 5
<212> PRT
<213> Corynebacterium diphtheriae


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 5
Leu Pro Xaa Thr Gly 
1               5   


<210> 6
<211> 4
<212> PRT
<213> Corynebacterium diphtheriae

<400> 6
Tyr Pro Lys Asn 
1               


<210> 7
<211> 4
<212> PRT
<213> Corynebacterium diphtheriae

<400> 7
Leu Pro Leu Thr 
1               


<210> 8
<211> 4
<212> PRT
<213> Corynebacterium diphtheriae


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 8
Leu Pro Xaa Thr 
1               


<210> 9
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Lys Asn Ala Gly Phe Glu Leu Pro Leu Thr Gly Gly Ser Gly Arg Ile 
1               5                   10                  15      


<210> 10
<211> 8
<212> PRT
<213> Corynebacterium diphtheriae


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Tyr or Leu

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ser or Thr

<400> 10
Thr Pro Xaa Xaa Ile Asn Xaa His 
1               5               


<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Asp Gly Trp Leu Gln Asp Val His Val Tyr Pro Lys His Gln Ala Leu 
1               5                   10                  15      


Ser 
    


<210> 12
<211> 11
<212> PRT
<213> Corynebacterium diphtheriae


<220>
<221> MOD_RES
<222> (2)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<400> 12
Trp Xaa Xaa Xaa Val Xaa Val Tyr Pro Lys His 
1               5                   10      


<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Lys Asn Ala Gly Phe Glu Leu Pro Leu Thr Gly 
1               5                   10      


<210> 14
<211> 3
<212> PRT
<213> Corynebacterium diphtheriae

<400> 14
Gly Pro Gly 
1           


<210> 15
<211> 10
<212> PRT
<213> Corynebacterium diphtheriae

<400> 15
Leu Pro Leu Thr Gly Gly Ser Gly Arg Ile 
1               5                   10  


<210> 16
<211> 10
<212> PRT
<213> Corynebacterium diphtheriae


<220>
<221> MOD_RES
<222> (2)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<400> 16
Trp Xaa Xaa Xaa Val Xaa Val Tyr Pro Lys 
1               5                   10  


<210> 17
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Lys Asn Ala Gly Phe Glu Leu Pro Ala Thr Gly Gly Ser Gly Arg Ile 
1               5                   10                  15      


<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Cys Asn Ala Gly Phe Glu Leu Pro Ala Thr Gly Gly Ser Arg Ile 
1               5                   10                  15  


<210> 19
<211> 4
<212> PRT
<213> Corynebacterium diphtheriae

<400> 19
Cys Trp Ser Ser 
1               


<210> 20
<211> 31
<212> PRT
<213> Corynebacterium diphtheriae

<400> 20
Asp Pro Asn Lys Asp Gln Ile Thr Leu Ile Thr Cys Thr Pro Tyr Ala 
1               5                   10                  15      


Val Asn Ser His Arg Leu Leu Val Arg Ala His Arg Val Asp Leu 
            20                  25                  30      


<210> 21
<211> 31
<212> PRT
<213> Corynebacterium diphtheriae

<400> 21
Glu Gln Gly Lys Asp Tyr Ile Thr Leu Ile Thr Cys Thr Pro Tyr Gly 
1               5                   10                  15      


Ile Asn Thr His Arg Leu Met Val Arg Gly His Gln Val Pro Leu 
            20                  25                  30      


<210> 22
<211> 31
<212> PRT
<213> Corynebacterium diphtheriae

<400> 22
Thr Ser Asn Lys Asp Gln Val Thr Leu Ile Thr Cys Thr Pro Tyr Gly 
1               5                   10                  15      


Ile Asn Thr His Arg Leu Ile Ile Thr Ala Glu Arg Val Pro Met 
            20                  25                  30      


<210> 23
<211> 31
<212> PRT
<213> Corynebacterium diphtheriae

<400> 23
Gln Asp Asp Arg Asp Leu Val Thr Leu Val Thr Cys Thr Pro Leu Gly 
1               5                   10                  15      


Ile Asn Thr His Arg Ile Leu Val Thr Ala Glu Arg Ile Thr Pro 
            20                  25                  30      


<210> 24
<211> 31
<212> PRT
<213> Corynebacterium diphtheriae

<400> 24
Ile Pro Asp Arg Asp Leu Ile Thr Leu Val Thr Cys Thr Pro Tyr Gly 
1               5                   10                  15      


Ile Asn Thr His Arg Leu Leu Val Thr Ala Glu Arg Val Pro Met 
            20                  25                  30      


<210> 25
<211> 31
<212> PRT
<213> Lactobacillus rhamnosus

<400> 25
Val Pro Gly Gln Asp Leu Val Thr Leu Met Thr Cys Thr Pro Tyr Met 
1               5                   10                  15      


Ile Asn Ser His Arg Leu Leu Ile Thr Gly Arg Arg Ile Pro Tyr 
            20                  25                  30      


<210> 26
<211> 31
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      faecium class C sortase 1 sequence

<400> 26
Ser Glu Gly Glu Asp Leu Val Thr Leu Leu Thr Cys Thr Pro Tyr Met 
1               5                   10                  15      


Ile Asn Thr His Arg Leu Leu Val Thr Gly His Arg Ile Pro Tyr 
            20                  25                  30      


<210> 27
<211> 31
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      faecium class C sortase 2 sequence

<400> 27
Glu Lys Gly Gln Asp Phe Val Thr Leu Leu Thr Cys Thr Pro Tyr Met 
1               5                   10                  15      


Val Asn Ser His Arg Leu Leu Val Arg Gly His Arg Val Pro Tyr 
            20                  25                  30      


<210> 28
<211> 31
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      SrtC1 sequence

<400> 28
Glu Glu Gly Lys Asp Leu Leu Thr Leu Val Thr Cys Thr Pro Leu Gly 
1               5                   10                  15      


Ile Asn Thr His Arg Ile Leu Leu Thr Gly Glu Arg Ile Tyr Pro 
            20                  25                  30      


<210> 29
<211> 31
<212> PRT
<213> Actinomyces oris

<400> 29
Val Pro Gly Arg Asp Leu Val Thr Leu Ile Thr Cys Thr Pro Tyr Gly 
1               5                   10                  15      


Val Asn Ser His Arg Leu Leu Val Thr Gly Glu Arg Val Pro Met 
            20                  25                  30      


<210> 30
<211> 31
<212> PRT
<213> Streptococcus pneumoniae

<400> 30
Gln His Gly Glu Asp Tyr Ala Thr Leu Leu Thr Cys Thr Pro Tyr Met 
1               5                   10                  15      


Ile Asn Ser His Arg Leu Leu Val Arg Gly Lys Arg Ile Pro Tyr 
            20                  25                  30      


<210> 31
<211> 31
<212> PRT
<213> Streptococcus agalactiae

<400> 31
Ile Gln Gly Glu Asp His Val Thr Leu Leu Thr Cys Thr Pro Tyr Met 
1               5                   10                  15      


Ile Asn Ser His Arg Leu Leu Val Arg Gly Lys Arg Ile Pro Tyr 
            20                  25                  30      


<210> 32
<211> 31
<212> PRT
<213> Streptococcus agalactiae

<400> 32
Val Asn Gly Lys Asp Tyr Ile Thr Leu Leu Thr Cys Thr Pro Tyr Met 
1               5                   10                  15      


Ile Asn Ser His Arg Leu Leu Val Lys Gly Glu Arg Ile Pro Tyr 
            20                  25                  30      


<210> 33
<211> 31
<212> PRT
<213> Bacillus cereus

<400> 33
Val Gln Asn Lys Asp Tyr Thr Thr Leu Ile Thr Cys Thr Pro Tyr Gly 
1               5                   10                  15      


Ile Asn Thr Asn Arg Leu Leu Val Arg Gly Glu Arg Val Glu Leu 
            20                  25                  30      


<210> 34
<211> 31
<212> PRT
<213> Ruminococcus albus

<400> 34
Ile Pro Asn Glu Asp Glu Val Thr Leu Met Thr Cys Thr Pro Tyr Gly 
1               5                   10                  15      


Ile Asn Thr His Arg Leu Leu Ile Arg Ala His Arg Ile Lys Ser 
            20                  25                  30      


<210> 35
<211> 35
<212> PRT
<213> Staphylococcus aureus

<400> 35
Gln Lys Gly Lys Asp Lys Gln Leu Thr Leu Ile Thr Cys Asp Asp Tyr 
1               5                   10                  15      


Asn Glu Lys Thr Gly Val Trp Glu Lys Arg Lys Ile Phe Val Ala Thr 
            20                  25                  30          


Glu Val Lys 
        35  


<210> 36
<211> 30
<212> PRT
<213> Streptococcus pyogenes

<400> 36
Lys His His Thr Lys Phe Val Ala Phe Ser Thr Cys Glu Asn Phe Ser 
1               5                   10                  15      


Thr Asp Asn Arg Val Ile Val Val Gly Thr Ile Gln Glu Ile 
            20                  25                  30  


<210> 37
<211> 24
<212> PRT
<213> Clostridium perfringens

<400> 37
Lys Thr Met Thr Ile Val Thr Cys Thr Asn Arg Gly Lys Asp Arg Tyr 
1               5                   10                  15      


Ile Val Lys Ala Lys Leu Ile Gly 
            20                  


<210> 38
<211> 32
<212> PRT
<213> Streptomyces coelicolor

<400> 38
Phe Lys Gly Pro Gly Arg Tyr Ile Thr Leu Thr Thr Cys Thr Pro Glu 
1               5                   10                  15      


Phe Thr Ser Lys Tyr Arg Met Ile Val Trp Gly Lys Met Val Glu Glu 
            20                  25                  30          


<210> 39
<211> 32
<212> PRT
<213> Corynebacterium diphtheriae

<400> 39
Asp Pro Gly Met Glu Gly Ile Met Thr Met Thr Thr Cys His Pro Gln 
1               5                   10                  15      


Phe Ser Asn Ala Glu Arg Met Ile Val His Ala Met Leu Thr Glu His 
            20                  25                  30          


<210> 40
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Asn Asn Ala Arg Gln Ala Arg Val Ala Gln Ser Tyr Glu Asn Ser Tyr 
1               5                   10                  15      


Glu Val Asp Ser Pro Ala Val Arg Asp Ser Val Leu Glu Ala Ala Arg 
            20                  25                  30          


Gln Tyr Asn Thr Ser Val Val Gly Phe Pro Ser Lys Asn Ser Gly Pro 
        35                  40                  45              


Tyr Leu Asp Tyr Leu Gln Gln Leu Asn Pro Gln Arg Ala Glu Arg Pro 
    50                  55                  60                  


Val Ile Ala Ser Ile Ser Ile Pro Thr Ile Asp Ala His Leu Pro Ile 
65                  70                  75                  80  


Tyr His Gly Thr Asp Thr Ala Thr Leu Glu His Gly Leu Gly His Leu 
                85                  90                  95      


Tyr Gly Ser Ala Leu Pro Val Gly Gly Thr Gly Thr His Pro Val Ile 
            100                 105                 110         


Thr Gly His Ser Gly Leu Ala Asn Ala Thr Leu Phe Asp Asn Leu Glu 
        115                 120                 125             


Asp Val Lys Glu His Asp Pro Ile Tyr Ile Thr Val Gln Gly Glu Thr 
    130                 135                 140                 


Leu Lys Tyr Glu Val Asp Ala Ile Asn Val Val Leu Pro Glu Asp Thr 
145                 150                 155                 160 


Lys Leu Leu Ala Pro Asp Pro Asn Lys Asp Gln Ile Thr Leu Ile Thr 
                165                 170                 175     


Cys Thr Pro Tyr Ala Val Asn Ser His Arg Leu Leu Val Arg Ala His 
            180                 185                 190         


Arg Val Asp Leu Asp Pro Asn Asp Pro Asn Leu Thr Gln Thr Gly Thr 
        195                 200                 205             


Lys Ile Trp Gln 
    210         


<210> 41
<211> 289
<212> PRT
<213> Corynebacterium diphtheriae

<400> 41
Met Arg His Arg Ala Gly Glu His Arg Asn Val Phe Ala Ile Leu Ala 
1               5                   10                  15      


Phe Val Ile Ala Ile Val Ser Val Gly Phe Leu Leu Tyr Pro Val Ala 
            20                  25                  30          


Ala Thr Ala Trp Asn Asn Ala Arg Gln Ala Arg Val Ala Gln Ser Tyr 
        35                  40                  45              


Glu Asn Ser Tyr Glu Val Asp Ser Pro Ala Val Arg Asp Ser Val Leu 
    50                  55                  60                  


Glu Ala Ala Arg Gln Tyr Asn Thr Ser Val Val Gly Phe Pro Ile Leu 
65                  70                  75                  80  


Asp Pro Trp Leu Asn Arg Ala Ser Lys Asn Ser Gly Pro Tyr Leu Asp 
                85                  90                  95      


Tyr Leu Gln Gln Leu Asn Pro Gln Arg Ala Glu Arg Pro Val Ile Ala 
            100                 105                 110         


Ser Ile Ser Ile Pro Thr Ile Asp Ala His Leu Pro Ile Tyr His Gly 
        115                 120                 125             


Thr Asp Thr Ala Thr Leu Glu His Gly Leu Gly His Leu Tyr Gly Ser 
    130                 135                 140                 


Ala Leu Pro Val Gly Gly Thr Gly Thr His Pro Val Ile Thr Gly His 
145                 150                 155                 160 


Ser Gly Leu Ala Asn Ala Thr Leu Phe Asp Asn Leu Glu Asp Val Lys 
                165                 170                 175     


Glu His Asp Pro Ile Tyr Ile Thr Val Gln Gly Glu Thr Leu Lys Tyr 
            180                 185                 190         


Glu Val Asp Ala Ile Asn Val Val Leu Pro Glu Asp Thr Lys Leu Leu 
        195                 200                 205             


Ala Pro Asp Pro Asn Lys Asp Gln Ile Thr Leu Ile Thr Cys Thr Pro 
    210                 215                 220                 


Tyr Ala Val Asn Ser His Arg Leu Leu Val Arg Ala His Arg Val Asp 
225                 230                 235                 240 


Leu Asp Pro Asn Asp Pro Asn Leu Thr Gln Thr Gly Thr Lys Ile Trp 
                245                 250                 255     


Gln Pro Trp Met Leu Trp Thr Ala Ala Leu Ala Leu Thr Ala Ile Ala 
            260                 265                 270         


Ile Ile Ile Thr Leu Val Leu Arg Arg Lys Arg Thr Thr Thr His Glu 
        275                 280                 285             


Lys 
    


