                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY 
      DISEASE OR DISORDER

<130> 043214-092230WOPT

<140> PCT/US2019/030546
<141> 2019-05-03

<150> 62/666,787
<151> 2018-05-04

<160> 47    

<170> PatentIn version 3.5

<210> 1
<211> 2235
<212> DNA
<213> Homo sapiens

<400> 1
atggagcagg atcccaagcc gccccgtctg cggctctggg ccctgatccc ctggcttccc       60

aggaagcagc ggcccaggat cagccagacc tctctgcctg tccctggccc tggctctggc      120

ccccagcggg actcggatga gggcgtcctc aaggagatct ccatcacgca ccacgtcaag      180

gctggctctg agaaggctga tccatcccat ttcgagctcc tcaaggttct gggccaggga      240

tcctttggca aagtcttcct ggtgcggaaa gtcacccggc ctgacagtgg gcacctgtat      300

gctatgaagg tgctgaagaa ggcaacgctg aaagtacgtg accgcgtccg gaccaagatg      360

gagagagaca tcctggctga tgtaaatcac ccattcgtgg tgaagctgca ctatgccttc      420

cagaccgagg gcaagctcta tctcattctg gacttcctgc gtggtgggga cctcttcacc      480

cggctctcaa aagaggtgat gttcacggag gaggatgtga agttttacct ggccgagctg      540

gctctgggcc tggatcacct gcacagcctg ggtatcattt acagagacct caagcctgag      600

aacatccttc tggatgagga gggccacatc aaactcactg actttggcct gagcaaagag      660

gccattgacc acgagaagaa ggcctattct ttctgcggga cagtggagta catggcccct      720

gaggtcgtca accgccaggg ccactcccat agtgcggact ggtggtccta tggggtgttg      780

atgtttgaga tgctgacggg ctccctgccc ttccagggga aggaccggaa ggagaccatg      840

acactgattc tgaaggcgaa gctaggcatg ccccagtttc tgagcactga agcccagagc      900

ctcttgcggg ccctgttcaa gcggaatcct gccaaccggc tcggctccgg ccctgatggg      960

gcagaggaaa tcaagcggca tgtcttctac tccaccattg actggaataa gctataccgt     1020

cgtgagatca agccaccctt caagccagca gtggctcagc ctgatgacac cttctacttt     1080

gacaccgagt tcacgtcccg cacacccaag gattccccag gcatcccccc cagcgctggg     1140

gcccatcagc tgttccgggg cttcagcttc gtggccaccg gcctgatgga agacgacggc     1200

aagcctcgtg ccccgcaggc acccctgcac tcggtggtac agcaactcca tgggaagaac     1260

ctggttttta gtgacggcta cgtggtaaag gagacaattg gtgtgggctc ctactctgag     1320

tgcaagcgct gtgtccacaa ggccaccaac atggagtatg ctgtcaaggt cattgataag     1380

agcaagcggg atccttcaga agagattgag attcttctgc ggtatggcca gcaccccaac     1440

atcatcactc tgaaagatgt gtatgatgat ggcaaacacg tgtacctggt gacagagctg     1500

atgcggggtg gggagctgct ggacaagatc ctgcggcaga agttcttctc agagcgggag     1560

gccagctttg tcctgcacac cattggcaaa actgtggagt atctgcactc acagggggtt     1620

gtgcacaggg acctgaagcc cagcaacatc ctgtatgtgg acgagtccgg gaatcccgag     1680

tgcctgcgca tctgtgactt tggttttgcc aaacagctgc gggctgagaa tgggctcctc     1740

atgacacctt gctacacagc caactttgtg gcgcctgagg tgctgaagcg ccagggctac     1800

gatgaaggct gcgacatctg gagcctgggc attctgctgt acaccatgct ggcaggatat     1860

actccatttg ccaacggtcc cagtgacaca ccagaggaaa tcctaacccg gatcggcagt     1920

gggaagttta ccctcagtgg gggaaattgg aacacagttt cagagacagc caaggacctg     1980

gtgtccaaga tgctacacgt ggatccccac cagcgcctca cagctaagca ggttctgcag     2040

catccatggg tcacccagaa agacaagctt ccccaaagcc agctgtccca ccaggaccta     2100

cagcttgtga agggagccat ggctgccacg tactccgcac tcaacagctc caagcccacc     2160

ccccagctga agcccatcga gtcatccatc ctggcccagc ggcgagtgag gaagttgcca     2220

tccaccaccc tgtga                                                      2235


<210> 2
<211> 744
<212> PRT
<213> Homo sapiens

<400> 2
Met Glu Gln Asp Pro Lys Pro Pro Arg Leu Arg Leu Trp Ala Leu Ile 
1               5                   10                  15      


Pro Trp Leu Pro Arg Lys Gln Arg Pro Arg Ile Ser Gln Thr Ser Leu 
            20                  25                  30          


Pro Val Pro Gly Pro Gly Ser Gly Pro Gln Arg Asp Ser Asp Glu Gly 
        35                  40                  45              


Val Leu Lys Glu Ile Ser Ile Thr His His Val Lys Ala Gly Ser Glu 
    50                  55                  60                  


Lys Ala Asp Pro Ser His Phe Glu Leu Leu Lys Val Leu Gly Gln Gly 
65                  70                  75                  80  


Ser Phe Gly Lys Val Phe Leu Val Arg Lys Val Thr Arg Pro Asp Ser 
                85                  90                  95      


Gly His Leu Tyr Ala Met Lys Val Leu Lys Lys Ala Thr Leu Lys Val 
            100                 105                 110         


Arg Asp Arg Val Arg Thr Lys Met Glu Arg Asp Ile Leu Ala Asp Val 
        115                 120                 125             


Asn His Pro Phe Val Val Lys Leu His Tyr Ala Phe Gln Thr Glu Gly 
    130                 135                 140                 


Lys Leu Tyr Leu Ile Leu Asp Phe Leu Arg Gly Gly Asp Leu Phe Thr 
145                 150                 155                 160 


Arg Leu Ser Lys Glu Val Met Phe Thr Glu Glu Asp Val Lys Phe Tyr 
                165                 170                 175     


Leu Ala Glu Leu Ala Leu Gly Leu Asp His Leu His Ser Leu Gly Ile 
            180                 185                 190         


Ile Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp Glu Glu Gly 
        195                 200                 205             


His Ile Lys Leu Thr Asp Phe Gly Leu Ser Lys Glu Ala Ile Asp His 
    210                 215                 220                 


Glu Lys Lys Ala Tyr Ser Phe Cys Gly Thr Val Glu Tyr Met Ala Pro 
225                 230                 235                 240 


Glu Val Val Asn Arg Gln Gly His Ser His Ser Ala Asp Trp Trp Ser 
                245                 250                 255     


Tyr Gly Val Leu Met Phe Glu Met Leu Thr Gly Ser Leu Pro Phe Gln 
            260                 265                 270         


Gly Lys Asp Arg Lys Glu Thr Met Thr Leu Ile Leu Lys Ala Lys Leu 
        275                 280                 285             


Gly Met Pro Gln Phe Leu Ser Thr Glu Ala Gln Ser Leu Leu Arg Ala 
    290                 295                 300                 


Leu Phe Lys Arg Asn Pro Ala Asn Arg Leu Gly Ser Gly Pro Asp Gly 
305                 310                 315                 320 


Ala Glu Glu Ile Lys Arg His Val Phe Tyr Ser Thr Ile Asp Trp Asn 
                325                 330                 335     


Lys Leu Tyr Arg Arg Glu Ile Lys Pro Pro Phe Lys Pro Ala Val Ala 
            340                 345                 350         


Gln Pro Asp Asp Thr Phe Tyr Phe Asp Thr Glu Phe Thr Ser Arg Thr 
        355                 360                 365             


Pro Lys Asp Ser Pro Gly Ile Pro Pro Ser Ala Gly Ala His Gln Leu 
    370                 375                 380                 


Phe Arg Gly Phe Ser Phe Val Ala Thr Gly Leu Met Glu Asp Asp Gly 
385                 390                 395                 400 


Lys Pro Arg Ala Pro Gln Ala Pro Leu His Ser Val Val Gln Gln Leu 
                405                 410                 415     


His Gly Lys Asn Leu Val Phe Ser Asp Gly Tyr Val Val Lys Glu Thr 
            420                 425                 430         


Ile Gly Val Gly Ser Tyr Ser Glu Cys Lys Arg Cys Val His Lys Ala 
        435                 440                 445             


Thr Asn Met Glu Tyr Ala Val Lys Val Ile Asp Lys Ser Lys Arg Asp 
    450                 455                 460                 


Pro Ser Glu Glu Ile Glu Ile Leu Leu Arg Tyr Gly Gln His Pro Asn 
465                 470                 475                 480 


Ile Ile Thr Leu Lys Asp Val Tyr Asp Asp Gly Lys His Val Tyr Leu 
                485                 490                 495     


Val Thr Glu Leu Met Arg Gly Gly Glu Leu Leu Asp Lys Ile Leu Arg 
            500                 505                 510         


Gln Lys Phe Phe Ser Glu Arg Glu Ala Ser Phe Val Leu His Thr Ile 
        515                 520                 525             


Gly Lys Thr Val Glu Tyr Leu His Ser Gln Gly Val Val His Arg Asp 
    530                 535                 540                 


Leu Lys Pro Ser Asn Ile Leu Tyr Val Asp Glu Ser Gly Asn Pro Glu 
545                 550                 555                 560 


Cys Leu Arg Ile Cys Asp Phe Gly Phe Ala Lys Gln Leu Arg Ala Glu 
                565                 570                 575     


Asn Gly Leu Leu Met Thr Pro Cys Tyr Thr Ala Asn Phe Val Ala Pro 
            580                 585                 590         


Glu Val Leu Lys Arg Gln Gly Tyr Asp Glu Gly Cys Asp Ile Trp Ser 
        595                 600                 605             


Leu Gly Ile Leu Leu Tyr Thr Met Leu Ala Gly Tyr Thr Pro Phe Ala 
    610                 615                 620                 


Asn Gly Pro Ser Asp Thr Pro Glu Glu Ile Leu Thr Arg Ile Gly Ser 
625                 630                 635                 640 


Gly Lys Phe Thr Leu Ser Gly Gly Asn Trp Asn Thr Val Ser Glu Thr 
                645                 650                 655     


Ala Lys Asp Leu Val Ser Lys Met Leu His Val Asp Pro His Gln Arg 
            660                 665                 670         


Leu Thr Ala Lys Gln Val Leu Gln His Pro Trp Val Thr Gln Lys Asp 
        675                 680                 685             


Lys Leu Pro Gln Ser Gln Leu Ser His Gln Asp Leu Gln Leu Val Lys 
    690                 695                 700                 


Gly Ala Met Ala Ala Thr Tyr Ser Ala Leu Asn Ser Ser Lys Pro Thr 
705                 710                 715                 720 


Pro Gln Leu Lys Pro Ile Glu Ser Ser Ile Leu Ala Gln Arg Arg Val 
                725                 730                 735     


Arg Lys Leu Pro Ser Thr Thr Leu 
            740                 


<210> 3
<211> 2253
<212> DNA
<213> Homo sapiens

<400> 3
atgtctcagt ggtacgaact tcagcagctt gactcaaaat tcctggagca ggttcaccag       60

ctttatgatg acagttttcc catggaaatc agacagtacc tggcacagtg gttagaaaag      120

caagactggg agcacgctgc caatgatgtt tcatttgcca ccatccgttt tcatgacctc      180

ctgtcacagc tggatgatca atatagtcgc ttttctttgg agaataactt cttgctacag      240

cataacataa ggaaaagcaa gcgtaatctt caggataatt ttcaggaaga cccaatccag      300

atgtctatga tcatttacag ctgtctgaag gaagaaagga aaattctgga aaacgcccag      360

agatttaatc aggctcagtc ggggaatatt cagagcacag tgatgttaga caaacagaaa      420

gagcttgaca gtaaagtcag aaatgtgaag gacaaggtta tgtgtataga gcatgaaatc      480

aagagcctgg aagatttaca agatgaatat gacttcaaat gcaaaacctt gcagaacaga      540

gaacacgaga ccaatggtgt ggcaaagagt gatcagaaac aagaacagct gttactcaag      600

aagatgtatt taatgcttga caataagaga aaggaagtag ttcacaaaat aatagagttg      660

ctgaatgtca ctgaacttac ccagaatgcc ctgattaatg atgaactagt ggagtggaag      720

cggagacagc agagcgcctg tattgggggg ccgcccaatg cttgcttgga tcagctgcag      780

aactggttca ctatagttgc ggagagtctg cagcaagttc ggcagcagct taaaaagttg      840

gaggaattgg aacagaaata cacctacgaa catgacccta tcacaaaaaa caaacaagtg      900

ttatgggacc gcaccttcag tcttttccag cagctcattc agagctcgtt tgtggtggaa      960

agacagccct gcatgccaac gcaccctcag aggccgctgg tcttgaagac aggggtccag     1020

ttcactgtga agttgagact gttggtgaaa ttgcaagagc tgaattataa tttgaaagtc     1080

aaagtcttat ttgataaaga tgtgaatgag agaaatacag taaaaggatt taggaagttc     1140

aacattttgg gcacgcacac aaaagtgatg aacatggagg agtccaccaa tggcagtctg     1200

gcggctgaat ttcggcacct gcaattgaaa gaacagaaaa atgctggcac cagaacgaat     1260

gagggtcctc tcatcgttac tgaagagctt cactccctta gttttgaaac ccaattgtgc     1320

cagcctggtt tggtaattga cctcgagacg acctctctgc ccgttgtggt gatctccaac     1380

gtcagccagc tcccgagcgg ttgggcctcc atcctttggt acaacatgct ggtggcggaa     1440

cccaggaatc tgtccttctt cctgactcca ccatgtgcac gatgggctca gctttcagaa     1500

gtgctgagtt ggcagttttc ttctgtcacc aaaagaggtc tcaatgtgga ccagctgaac     1560

atgttgggag agaagcttct tggtcctaac gccagccccg atggtctcat tccgtggacg     1620

aggttttgta aggaaaatat aaatgataaa aattttccct tctggctttg gattgaaagc     1680

atcctagaac tcattaaaaa acacctgctc cctctctgga atgatgggtg catcatgggc     1740

ttcatcagca aggagcgaga gcgtgccctg ttgaaggacc agcagccggg gaccttcctg     1800

ctgcggttca gtgagagctc ccgggaaggg gccatcacat tcacatgggt ggagcggtcc     1860

cagaacggag gcgaacctga cttccatgcg gttgaaccct acacgaagaa agaactttct     1920

gctgttactt tccctgacat cattcgcaat tacaaagtca tggctgctga gaatattcct     1980

gagaatcccc tgaagtatct gtatccaaat attgacaaag accatgcctt tggaaagtat     2040

tactccaggc caaaggaagc accagagcca atggaacttg atggccctaa aggaactgga     2100

tatatcaaga ctgagttgat ttctgtgtct gaagttcacc cttctagact tcagaccaca     2160

gacaacctgc tccccatgtc tcctgaggag tttgacgagg tgtctcggat agtgggctct     2220

gtagaattcg acagtatgat gaacacagta tag                                  2253


<210> 4
<211> 750
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 
                725                 730                 735     


Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val 
            740                 745                 750 


<210> 5
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Met-oxide

<220>
<221> MOD_RES
<222> (11)..(11)
<223> PhosphoSer

<400> 5
Leu Gln Thr Thr Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp 
1               5                   10                  15      


Glu Val Ser Arg 
            20  


<210> 6
<211> 19
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      non-targeting control pool sequence

<400> 6
ugguuuacau gucgacuaa                                                    19


<210> 7
<211> 19
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      non-targeting control pool sequence

<400> 7
ugguuuacau guuguguga                                                    19


<210> 8
<211> 19
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      non-targeting control pool sequence

<400> 8
ugguuuacau guuuucuga                                                    19


<210> 9
<211> 19
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      non-targeting control pool sequence

<400> 9
ugguuuacau guuuuccua                                                    19


<210> 10
<211> 19
<212> RNA
<213> Homo sapiens

<400> 10
gugggcaccu guaugcuau                                                    19


<210> 11
<211> 19
<212> RNA
<213> Homo sapiens

<400> 11
gauaagagca agcgggauc                                                    19


<210> 12
<211> 19
<212> RNA
<213> Homo sapiens

<400> 12
gaaaguacgu gaccgcguc                                                    19


<210> 13
<211> 19
<212> RNA
<213> Homo sapiens

<400> 13
gaacacaguu ucagagaca                                                    19


<210> 14
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> PhosphoThr

<400> 14
Arg Arg Ala Glu Thr Phe Gly Gly Phe Asp Ser His Gln Met Asn Ala 
1               5                   10                  15      


Ser Lys Gly 
            


<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoThr

<400> 15
Arg Leu Asn Thr Ser Asp Phe Gln Lys Leu 
1               5                   10  


<210> 16
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoThr

<400> 16
Arg Ser Lys Thr Glu Glu Asp Ile Leu Arg Ala 
1               5                   10      


<210> 17
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoThr

<400> 17
Arg Ala Ser Thr Leu Leu Arg Asp Glu Glu Leu Glu Glu Ile Lys Lys 
1               5                   10                  15      


Glu 
    


<210> 18
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 18
Arg Arg Gln Ser Ser Gly Ser Ala Thr Asn Val Ala Ser Thr Pro Asp 
1               5                   10                  15      


Asn Arg Gly 
            


<210> 19
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 19
Arg Arg Lys Ser Gln Val Asn Gly Glu Ala Gly Ser Tyr Glu Met Thr 
1               5                   10                  15      


Asn Gln His Val Lys Gln 
            20          


<210> 20
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> PhosphoSer

<400> 20
Arg Leu Arg Arg Pro Ser Val Asn Gly Glu Pro Gly Ser Val Pro Pro 
1               5                   10                  15      


Pro Arg Ala 
            


<210> 21
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 21
Arg Thr Gly Ser Glu Ser Ser Gln Thr Gly Thr Ser Thr Thr Ser Ser 
1               5                   10                  15      


Arg Ser Asn 
            


<210> 22
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> PhosphoSer

<400> 22
Arg Arg Ala Pro Ser Val Ala Asn Val Gly Ser His Cys Asp Leu Ser 
1               5                   10                  15      


Leu Lys Ile 
            


<210> 23
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> PhosphoSer

<400> 23
Arg Arg His Asn Ser Ser Asp Gly Phe Asp Ser Ala Ile Gly Arg Pro 
1               5                   10                  15      


Asn Gly Gly Asn Phe Gly Arg Lys 
            20                  


<210> 24
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 24
Arg His Asn Ser Ser Asp Gly Phe Asp Ser Ala Ile Gly Arg Pro Asn 
1               5                   10                  15      


Gly Gly Asn Phe Gly Arg Lys 
            20              


<210> 25
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoThr

<400> 25
Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr 
1               5                   10              


<210> 26
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoThr

<400> 26
Arg Leu Thr Thr Leu Ala Leu Asn Gly Asn Arg Leu Thr Arg Ala Val 
1               5                   10                  15      


Leu Arg Asp 
            


<210> 27
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoThr

<400> 27
Arg Lys Arg Thr Glu Glu Pro Asp Arg Asp Glu Arg Leu 
1               5                   10              


<210> 28
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoThr

<400> 28
Arg Arg Asn Thr Thr Gln Asn Thr Gly Tyr Ser Ser Gly Thr Gln Asn 
1               5                   10                  15      


Ala Asn Tyr Pro Val Arg Ala 
            20              


<210> 29
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 29
Arg Thr Ala Ser Gly Ser Ser Val Thr Ser Leu Asp Gly Thr Arg Ser 
1               5                   10                  15      


<210> 30
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 30
Arg Thr His Ser Thr Ser Ser Ser Leu Gly Ser Gly Glu Ser Pro Phe 
1               5                   10                  15      


Ser Arg Ser 
            


<210> 31
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> PhosphoSer

<400> 31
Arg Arg Leu Lys Ser Glu Asp Glu Leu Arg Pro Glu Val Asp Glu His 
1               5                   10                  15      


Thr Gln Lys Thr 
            20  


<210> 32
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 32
Arg Leu Lys Ser Glu Asp Glu Leu Arg Pro Glu Val Asp Glu His Thr 
1               5                   10                  15      


Gln Lys Thr 
            


<210> 33
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> PhosphoSer

<400> 33
Lys Arg Arg Arg Leu Ser Ser Leu Arg Ala Ser Thr Ser Lys Ser 
1               5                   10                  15  


<210> 34
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(5)
<223> PhosphoSer

<400> 34
Arg Arg Leu Ser Ser Leu Arg Ala Ser Thr Ser Lys Ser 
1               5                   10              


<210> 35
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> PhosphoSer

<400> 35
Arg Glu Arg Leu Pro Ser Val Asp Leu Lys Glu 
1               5                   10      


<210> 36
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 36
Arg Glu Asn Ser Thr Val Asp Phe Ser Lys Val Glu Gly 
1               5                   10              


<210> 37
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 37
Arg Arg Ser Ser Thr Ser Ser Glu Pro Thr Pro Thr Val Lys Thr 
1               5                   10                  15  


<210> 38
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 38
Arg Arg Ala Ser Ile Ser Glu Pro Ser Asp Thr Asp Pro Glu Pro Arg 
1               5                   10                  15      


Thr 
    


<210> 39
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 39
Arg Ala Ser Ser Arg Val Ser Gly Ser Phe Pro Glu Asp Ser Ser Lys 
1               5                   10                  15      


Glu 
    


<210> 40
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 40
Arg Arg Pro Ser Thr Glu Asp Thr His Glu Val Asp Ser Lys Ala 
1               5                   10                  15  


<210> 41
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer or PhosphoThr

<400> 41
Arg Xaa Xaa Xaa 
1               


<210> 42
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ser or Thr

<400> 42
Arg Xaa Xaa Xaa 
1               


<210> 43
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 43
Leu Pro Met Ser 
1               


<210> 44
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 44
Tyr Leu Arg Ser 
1               


<210> 45
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 45
Met Gln Pro Ser 
1               


<210> 46
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> PhosphoSer

<400> 46
Pro Asn Arg Ser 
1               


<210> 47
<211> 19
<212> PRT
<213> Homo sapiens

<400> 47
Lys Ala Tyr Ser Phe Cys Gly Thr Val Glu Tyr Met Ala Pro Glu Val 
1               5                   10                  15      


Val Asn Arg 
            


