                         SEQUENCE LISTING

<110>  CRISPR THERAPEUTICS AG
 
<120>  METHODS AND COMPOSITIONS FOR TREATING CANCER

<130>  AC1992 PCT S3

<140>  PCT/IB2019/000500
<141>  2019-05-10

<150>  US 62/670,417
<151>  2018-05-11

<150>  US 62/701,340
<151>  2018-07-20

<150>  US 62/756,643
<151>  2018-11-07

<150>  US 62/773,658
<151>  2018-11-30

<150>  US 62/826,600
<151>  2019-03-29

<160>  180   

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC Indel

<400>  1
aagagcaaca aatctgact                                                    19


<210>  2
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC Indel

<400>  2
aagagcaaca gtgctgtgcc tggagcaaca aatctgacta agagcaacaa atctgact         58


<210>  3
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC Indel

<400>  3
aagagcaaca gtgctggagc aacaaatctg actaagagca acaaatctga ct               52


<210>  4
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC Indel

<400>  4
aagagcaaca gtgcctggag caacaaatct gactaagagc aacaaatctg act              53


<210>  5
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC Indel

<400>  5
aagagcaaca gtgctgacta agagcaacaa atctgact                               38


<210>  6
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC Indel

<400>  6
aagagcaaca gtgctgtggg cctggagcaa caaatctgac taagagcaac aaatctgact       60


<210>  7
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC Indel

<400>  7
aagagcaaca gtgctggcct ggagcaacaa atctgactaa gagcaacaaa tctgact          57


<210>  8
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC Indel

<400>  8
aagagcaaca gtgctgtgtg cctggagcaa caaatctgac taagagcaac aaatctgact       60


<210>  9
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: B2M Indel

<400>  9
cgtggcctta gctgtgctcg cgctactctc tctttctgcc tggaggctat ccagcgtgag       60

tctctcctac cctcccgct                                                    79


<210>  10
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: B2M Indel

<400>  10
cgtggcctta gctgtgctcg cgctactctc tctttcgcct ggaggctatc cagcgtgagt       60

ctctcctacc ctcccgct                                                     78


<210>  11
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: B2M Indel

<400>  11
cgtggcctta gctgtgctcg cgctactctc tctttctgga ggctatccag cgtgagtctc       60

tcctaccctc ccgct                                                        75


<210>  12
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: B2M Indel

<400>  12
cgtggcctta gctgtgctcg cgctactctc tctttctgga tagcctggag gctatccagc       60

gtgagtctct cctaccctcc cgct                                              84


<210>  13
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: B2M Indel

<400>  13
cgtggcctta gctgtgctcg cgctatccag cgtgagtctc tcctaccctc ccgct            55


<210>  14
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: B2M Indel

<400>  14
cgtggcctta gctgtgctcg cgctactctc tctttctgtg gcctggaggc tatccagcgt       60

gagtctctcc taccctcccg ct                                                82


<210>  15
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: sgRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  15
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  16
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: sgRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  16
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210>  17
<211>  114
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: sgRNA


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (18)..(30)
<223>  n may be present or absent

<220>
<221>  misc_feature
<222>  (108)..(114)
<223>  u may be present or absent

<400>  17
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau       60

aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu uuuu            114


<210>  18
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4-1BB nucleotide sequence

<400>  18
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  19
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4-1BB amino acid sequence

<400>  19

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  20
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD28 amino acid sequence

<400>  20

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  21
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD3-z nucleotide sequence

<400>  21
cgagtgaagt tttcccgaag cgcagacgct ccggcatatc agcaaggaca gaatcagctg       60

tataacgaac tgaatttggg acgccgcgag gagtatgacg tgcttgataa acgccggggg      120

agagacccgg aaatgggggg taaaccccga agaaagaatc cccaagaagg actctacaat      180

gaactccaga aggataagat ggcggaggcc tactcagaaa taggtatgaa gggcgaacga      240

cgacggggaa aaggtcacga tggcctctac caagggttga gtacggcaac caaagatacg      300

tacgatgcac tgcatatgca ggccctgcct cccaga                                336


<210>  22
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD3-z amino acid sequence

<400>  22

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  23
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T1)

<400>  23
ucaccaagcc cgcgaccaau guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  24
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T3)

<400>  24
aucaccaagc ccgcgaccaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  25
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T4)

<400>  25
cggugcggcg caggcccuau guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  26
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T7)

<400>  26
gcuuuggucc cauuggucgc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  27
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T8)

<400>  27
gcccgcagga cgcacccaua guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  28
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T10)

<400>  28
gugcauccag cgcuucgcac guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  29
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E3_T1)

<400>  29
cagcuacgua uccaucguga guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  30
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC sgRNA

<400>  30
agagcaacag ugcuguggcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  31
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: b2M sgRNA

<400>  31
gcuacucucu cuuucuggcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  32
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: PD-1 sgRNA

<400>  32
cugcagcuuc uccaacacau guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  33
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T1)


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  2'-O-methyl phosphorothioate

<400>  33
ucaccaagcc cgcgaccaau guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  34
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T3)


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  2'-O-methyl phosphorothioate

<400>  34
aucaccaagc ccgcgaccaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  35
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T4)


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  2'-O-methyl phosphorothioate

<400>  35
cggugcggcg caggcccuau guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  36
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T7)


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  2'-O-methyl phosphorothioate

<400>  36
gcuuuggucc cauuggucgc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  37
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T8)


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  2'-O-methyl phosphorothioate

<400>  37
gcccgcagga cgcacccaua guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  38
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T10)


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  2'-O-methyl phosphorothioate

<400>  38
gugcauccag cgcuucgcac guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  39
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E3_T1)


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  2'-O-methyl phosphorothioate

<400>  39
cagcuacgua uccaucguga guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  40
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC sgRNA


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  2'-O-methyl phosphorothioate

<400>  40
agagcaacag ugcuguggcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  41
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: b2M sgRNA


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  2'-O-methyl phosphorothioate

<400>  41
gcuacucucu cuuucuggcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  42
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: PD-1 sgRNA


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  2'-O-methyl phosphorothioate

<400>  42
cugcagcuuc uccaacacau guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  43
<211>  4688
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 rAAV  (CD70B scFV with 41BB)

<400>  43
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgagatg taaggagctg ctgtgacttg ctcaaggcct      180

tatatcgagt aaacggtagt gctggggctt agacgcaggt gttctgattt atagttcaaa      240

acctctatca atgagagagc aatctcctgg taatgtgata gatttcccaa cttaatgcca      300

acataccata aacctcccat tctgctaatg cccagcctaa gttggggaga ccactccaga      360

ttccaagatg tacagtttgc tttgctgggc ctttttccca tgcctgcctt tactctgcca      420

gagttatatt gctggggttt tgaagaagat cctattaaat aaaagaataa gcagtattat      480

taagtagccc tgcatttcag gtttccttga gtggcaggcc aggcctggcc gtgaacgttc      540

actgaaatca tggcctcttg gccaagattg atagcttgtg cctgtccctg agtcccagtc      600

catcacgagc agctggtttc taagatgcta tttcccgtat aaagcatgag accgtgactt      660

gccagcccca cagagccccg cccttgtcca tcactggcat ctggactcca gcctgggttg      720

gggcaaagag ggaaatgaga tcatgtccta accctgatcc tcttgtccca cagatatcca      780

gaaccctgac cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg      840

cctattcacc gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta      900

tatcacagac aaaactgtgc tagacatgag gtctatggac ttcaggctcc ggtgcccgtc      960

agtgggcaga gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt     1020

gaaccggtgc ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc     1080

tccgcctttt tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg     1140

ttctttttcg caacgggttt gccgccagaa cacaggtaag tgccgtgtgt ggttcccgcg     1200

ggcctggcct ctttacgggt tatggccctt gcgtgccttg aattacttcc actggctgca     1260

gtacgtgatt cttgatcccg agcttcgggt tggaagtggg tgggagagtt cgaggccttg     1320

cgcttaagga gccccttcgc ctcgtgcttg agttgaggcc tggcctgggc gctggggccg     1380

ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct gctttcgata agtctctagc     1440

catttaaaat ttttgatgac ctgctgcgac gctttttttc tggcaagata gtcttgtaaa     1500

tgcgggccaa gatctgcaca ctggtatttc ggtttttggg gccgcgggcg gcgacggggc     1560

ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg cgagcgcggc caccgagaat     1620

cggacggggg tagtctcaag ctggccggcc tgctctggtg cctggcctcg cgccgccgtg     1680

tatcgccccg ccctgggcgg caaggctggc ccggtcggca ccagttgcgt gagcggaaag     1740

atggccgctt cccggccctg ctgcagggag ctcaaaatgg aggacgcggc gctcgggaga     1800

gcgggcgggt gagtcaccca cacaaaggaa aagggccttt ccgtcctcag ccgtcgcttc     1860

atgtgactcc acggagtacc gggcgccgtc caggcacctc gattagttct cgagcttttg     1920

gagtacgtcg tctttaggtt ggggggaggg gttttatgcg atggagtttc cccacactga     1980

gtgggtggag actgaagtta ggccagcttg gcacttgatg taattctcct tggaatttgc     2040

cctttttgag tttggatctt ggttcattct caagcctcag acagtggttc aaagtttttt     2100

tcttccattt caggtgtcgt gaccaccatg gcgcttccgg tgacagcact gctcctcccc     2160

ttggcgctgt tgctccacgc agcaaggccg caggtccagt tggtgcaaag cggggcggag     2220

gtgaaaaaac ccggcgcttc cgtgaaggtg tcctgtaagg cgtccggtta tacgttcacg     2280

aactacggga tgaattgggt tcgccaagcg ccggggcagg gactgaaatg gatggggtgg     2340

ataaatacct acaccggcga acctacatac gccgacgctt ttaaagggcg agtcactatg     2400

acgcgcgata ccagcatatc caccgcatac atggagctgt cccgactccg gtcagacgac     2460

acggctgtct actattgtgc tcgggactat ggcgattatg gcatggacta ctggggtcag     2520

ggtacgactg taacagttag tagtggtgga ggcggcagtg gcgggggggg aagcggagga     2580

gggggttctg gtgacatagt tatgacccaa tccccagata gtttggcggt ttctctgggc     2640

gagagggcaa cgattaattg tcgcgcatca aagagcgttt caacgagcgg atattctttt     2700

atgcattggt accagcaaaa acccggacaa ccgccgaagc tgctgatcta cttggcttca     2760

aatcttgagt ctggggtgcc ggaccgattt tctggtagtg gaagcggaac tgactttacg     2820

ctcacgatca gttcactgca ggctgaggat gtagcggtct attattgcca gcacagtaga     2880

gaagtcccct ggaccttcgg tcaaggcacg aaagtagaaa ttaaaagtgc tgctgccttt     2940

gtcccggtat ttctcccagc caaaccgacc acgactcccg ccccgcgccc tccgacaccc     3000

gctcccacca tcgcctctca acctcttagt cttcgccccg aggcatgccg acccgccgcc     3060

gggggtgctg ttcatacgag gggcttggac ttcgcttgtg atatttacat ttgggctccg     3120

ttggcgggta cgtgcggcgt ccttttgttg tcactcgtta ttactttgta ttgtaatcac     3180

aggaatcgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     3240

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     3300

ggaggatgtg aactgcgagt gaagttttcc cgaagcgcag acgctccggc atatcagcaa     3360

ggacagaatc agctgtataa cgaactgaat ttgggacgcc gcgaggagta tgacgtgctt     3420

gataaacgcc gggggagaga cccggaaatg gggggtaaac cccgaagaaa gaatccccaa     3480

gaaggactct acaatgaact ccagaaggat aagatggcgg aggcctactc agaaataggt     3540

atgaagggcg aacgacgacg gggaaaaggt cacgatggcc tctaccaagg gttgagtacg     3600

gcaaccaaag atacgtacga tgcactgcat atgcaggccc tgcctcccag ataataataa     3660

aatcgctatc catcgaagat ggatgtgtgt tggttttttg tgtgtggagc aacaaatctg     3720

actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc ttcttcccca     3780

gcccaggtaa gggcagcttt ggtgccttcg caggctgttt ccttgcttca ggaatggcca     3840

ggttctgccc agagctctgg tcaatgatgt ctaaaactcc tctgattggt ggtctcggcc     3900

ttatccattg ccaccaaaac cctcttttta ctaagaaaca gtgagccttg ttctggcagt     3960

ccagagaatg acacgggaaa aaagcagatg aagagaaggt ggcaggagag ggcacgtggc     4020

ccagcctcag tctctccaac tgagttcctg cctgcctgcc tttgctcaga ctgtttgccc     4080

cttactgctc ttctaggcct cattctaagc cccttctcca agttgcctct ccttatttct     4140

ccctgtctgc caaaaaatct ttcccagctc actaagtcag tctcacgcag tcactcatta     4200

acccaccaat cactgattgt gccggcacat gaatgcacca ggtgttgaag tggaggaatt     4260

aaaaagtcag atgaggggtg tgcccagagg aagcaccatt ctagttgggg gagcccatct     4320

gtcagctggg aaaagtccaa ataacttcag attggaatgt gttttaactc agggttgaga     4380

aaacagctac cttcaggaca aaagtcaggg aagggctctc tgaagaaatg ctacttgaag     4440

ataccagccc taccaagggc agggagagga ccctatagag gcctgggaca ggagctcaat     4500

gagaaaggta accacgtgcg gaccgaggct gcagcgtcgt cctccctagg aacccctagt     4560

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     4620

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg     4680

cctgcagg                                                              4688


<210>  44
<211>  4364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 LHA to RHA  (CD70B scFV with 41BB)

<400>  44
gagatgtaag gagctgctgt gacttgctca aggccttata tcgagtaaac ggtagtgctg       60

gggcttagac gcaggtgttc tgatttatag ttcaaaacct ctatcaatga gagagcaatc      120

tcctggtaat gtgatagatt tcccaactta atgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg ccgtgtacca      660

gctgagagac tctaaatcca gtgacaagtc tgtctgccta ttcaccgatt ttgattctca      720

aacaaatgtg tcacaaagta aggattctga tgtgtatatc acagacaaaa ctgtgctaga      780

catgaggtct atggacttca ggctccggtg cccgtcagtg ggcagagcgc acatcgccca      840

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc      900

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg      960

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     1020

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     1080

gcccttgcgt gccttgaatt acttccactg gctgcagtac gtgattcttg atcccgagct     1140

tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc cttcgcctcg     1200

tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct     1260

tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacctgc     1320

tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc tgcacactgg     1380

tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc gcacatgttc     1440

ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg     1500

ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag     1560

gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc     1620

agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca     1680

aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc     1740

gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt taggttgggg     1800

ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc     1860

agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg gatcttggtt     1920

cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg tgtcgtgacc     1980

accatggcgc ttccggtgac agcactgctc ctccccttgg cgctgttgct ccacgcagca     2040

aggccgcagg tccagttggt gcaaagcggg gcggaggtga aaaaacccgg cgcttccgtg     2100

aaggtgtcct gtaaggcgtc cggttatacg ttcacgaact acgggatgaa ttgggttcgc     2160

caagcgccgg ggcagggact gaaatggatg gggtggataa atacctacac cggcgaacct     2220

acatacgccg acgcttttaa agggcgagtc actatgacgc gcgataccag catatccacc     2280

gcatacatgg agctgtcccg actccggtca gacgacacgg ctgtctacta ttgtgctcgg     2340

gactatggcg attatggcat ggactactgg ggtcagggta cgactgtaac agttagtagt     2400

ggtggaggcg gcagtggcgg ggggggaagc ggaggagggg gttctggtga catagttatg     2460

acccaatccc cagatagttt ggcggtttct ctgggcgaga gggcaacgat taattgtcgc     2520

gcatcaaaga gcgtttcaac gagcggatat tcttttatgc attggtacca gcaaaaaccc     2580

ggacaaccgc cgaagctgct gatctacttg gcttcaaatc ttgagtctgg ggtgccggac     2640

cgattttctg gtagtggaag cggaactgac tttacgctca cgatcagttc actgcaggct     2700

gaggatgtag cggtctatta ttgccagcac agtagagaag tcccctggac cttcggtcaa     2760

ggcacgaaag tagaaattaa aagtgctgct gcctttgtcc cggtatttct cccagccaaa     2820

ccgaccacga ctcccgcccc gcgccctccg acacccgctc ccaccatcgc ctctcaacct     2880

cttagtcttc gccccgaggc atgccgaccc gccgccgggg gtgctgttca tacgaggggc     2940

ttggacttcg cttgtgatat ttacatttgg gctccgttgg cgggtacgtg cggcgtcctt     3000

ttgttgtcac tcgttattac tttgtattgt aatcacagga atcgcaaacg gggcagaaag     3060

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     3120

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gcgagtgaag     3180

ttttcccgaa gcgcagacgc tccggcatat cagcaaggac agaatcagct gtataacgaa     3240

ctgaatttgg gacgccgcga ggagtatgac gtgcttgata aacgccgggg gagagacccg     3300

gaaatggggg gtaaaccccg aagaaagaat ccccaagaag gactctacaa tgaactccag     3360

aaggataaga tggcggaggc ctactcagaa ataggtatga agggcgaacg acgacgggga     3420

aaaggtcacg atggcctcta ccaagggttg agtacggcaa ccaaagatac gtacgatgca     3480

ctgcatatgc aggccctgcc tcccagataa taataaaatc gctatccatc gaagatggat     3540

gtgtgttggt tttttgtgtg tggagcaaca aatctgactt tgcatgtgca aacgccttca     3600

acaacagcat tattccagaa gacaccttct tccccagccc aggtaagggc agctttggtg     3660

ccttcgcagg ctgtttcctt gcttcaggaa tggccaggtt ctgcccagag ctctggtcaa     3720

tgatgtctaa aactcctctg attggtggtc tcggccttat ccattgccac caaaaccctc     3780

tttttactaa gaaacagtga gccttgttct ggcagtccag agaatgacac gggaaaaaag     3840

cagatgaaga gaaggtggca ggagagggca cgtggcccag cctcagtctc tccaactgag     3900

ttcctgcctg cctgcctttg ctcagactgt ttgcccctta ctgctcttct aggcctcatt     3960

ctaagcccct tctccaagtt gcctctcctt atttctccct gtctgccaaa aaatctttcc     4020

cagctcacta agtcagtctc acgcagtcac tcattaaccc accaatcact gattgtgccg     4080

gcacatgaat gcaccaggtg ttgaagtgga ggaattaaaa agtcagatga ggggtgtgcc     4140

cagaggaagc accattctag ttgggggagc ccatctgtca gctgggaaaa gtccaaataa     4200

cttcagattg gaatgtgttt taactcaggg ttgagaaaac agctaccttc aggacaaaag     4260

tcagggaagg gctctctgaa gaaatgctac ttgaagatac cagccctacc aagggcaggg     4320

agaggaccct atagaggcct gggacaggag ctcaatgaga aagg                      4364


<210>  45
<211>  1527
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 CAR nucleotide sequence  (CD70B scFV with 41BB)

<400>  45
atggcgcttc cggtgacagc actgctcctc cccttggcgc tgttgctcca cgcagcaagg       60

ccgcaggtcc agttggtgca aagcggggcg gaggtgaaaa aacccggcgc ttccgtgaag      120

gtgtcctgta aggcgtccgg ttatacgttc acgaactacg ggatgaattg ggttcgccaa      180

gcgccggggc agggactgaa atggatgggg tggataaata cctacaccgg cgaacctaca      240

tacgccgacg cttttaaagg gcgagtcact atgacgcgcg ataccagcat atccaccgca      300

tacatggagc tgtcccgact ccggtcagac gacacggctg tctactattg tgctcgggac      360

tatggcgatt atggcatgga ctactggggt cagggtacga ctgtaacagt tagtagtggt      420

ggaggcggca gtggcggggg gggaagcgga ggagggggtt ctggtgacat agttatgacc      480

caatccccag atagtttggc ggtttctctg ggcgagaggg caacgattaa ttgtcgcgca      540

tcaaagagcg tttcaacgag cggatattct tttatgcatt ggtaccagca aaaacccgga      600

caaccgccga agctgctgat ctacttggct tcaaatcttg agtctggggt gccggaccga      660

ttttctggta gtggaagcgg aactgacttt acgctcacga tcagttcact gcaggctgag      720

gatgtagcgg tctattattg ccagcacagt agagaagtcc cctggacctt cggtcaaggc      780

acgaaagtag aaattaaaag tgctgctgcc tttgtcccgg tatttctccc agccaaaccg      840

accacgactc ccgccccgcg ccctccgaca cccgctccca ccatcgcctc tcaacctctt      900

agtcttcgcc ccgaggcatg ccgacccgcc gccgggggtg ctgttcatac gaggggcttg      960

gacttcgctt gtgatattta catttgggct ccgttggcgg gtacgtgcgg cgtccttttg     1020

ttgtcactcg ttattacttt gtattgtaat cacaggaatc gcaaacgggg cagaaagaaa     1080

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1140

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgcg agtgaagttt     1200

tcccgaagcg cagacgctcc ggcatatcag caaggacaga atcagctgta taacgaactg     1260

aatttgggac gccgcgagga gtatgacgtg cttgataaac gccgggggag agacccggaa     1320

atggggggta aaccccgaag aaagaatccc caagaaggac tctacaatga actccagaag     1380

gataagatgg cggaggccta ctcagaaata ggtatgaagg gcgaacgacg acggggaaaa     1440

ggtcacgatg gcctctacca agggttgagt acggcaacca aagatacgta cgatgcactg     1500

catatgcagg ccctgcctcc cagataa                                         1527


<210>  46
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 CAR amino acid sequence  (CD70B scFV with 41BB)

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr 
65                  70                  75                  80  


Tyr Ala Asp Ala Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Gly Asp Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile 
                165                 170                 175     


Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Phe Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
225                 230                 235                 240 


Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg Glu Val Pro Trp Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ala Ala Ala Phe Val 
            260                 265                 270         


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        275                 280                 285             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    290                 295                 300                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
305                 310                 315                 320 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                325                 330                 335     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
            340                 345                 350         


Asn Arg Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        355                 360                 365             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    370                 375                 380                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
385                 390                 395                 400 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                405                 410                 415     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            420                 425                 430         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        435                 440                 445             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    450                 455                 460                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
465                 470                 475                 480 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                485                 490                 495     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505             


<210>  47
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70A scFv nucleotide sequence

<400>  47
gatatagtta tgacccaatc acccgatagt cttgcggtaa gcctggggga gcgagcaaca       60

ataaactgtc gggcatcaaa atccgtcagt acaagcgggt attcattcat gcactggtat      120

caacagaaac ccggtcagcc acccaagctc ctgatttatc ttgcgtctaa tcttgagtcc      180

ggcgtcccag accggttttc cggctccggg agcggcacgg attttactct tactatttct      240

agccttcagg ccgaagatgt ggcggtatac tactgccagc attcaaggga agttccttgg      300

acgttcggtc agggcacgaa agtggaaatt aaaggcgggg ggggatccgg cgggggaggg      360

tctggaggag gtggcagtgg tcaggtccaa ctggtgcagt ccggggcaga ggtaaaaaaa      420

cccggcgcgt ctgttaaggt ttcatgcaag gccagtggat atactttcac caattacgga      480

atgaactggg tgaggcaggc ccctggtcaa ggcctgaaat ggatgggatg gataaacacg      540

tacaccggtg aacctaccta tgccgatgcc tttaagggtc gggttacgat gacgagagac      600

acctccatat caacagccta catggagctc agcagattga ggagtgacga tacggcagtc      660

tattactgtg caagagacta cggcgattat ggcatggatt actggggcca gggcactaca      720

gtaaccgttt ccagc                                                       735


<210>  48
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70A scFv amino acid sequence

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly 
145                 150                 155                 160 


Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly 
                165                 170                 175     


Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Ala Phe Lys 
            180                 185                 190         


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asp Tyr Gly Asp Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Thr 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  49
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70B scFv nucleotide sequence

<400>  49
caggtccagt tggtgcaaag cggggcggag gtgaaaaaac ccggcgcttc cgtgaaggtg       60

tcctgtaagg cgtccggtta tacgttcacg aactacggga tgaattgggt tcgccaagcg      120

ccggggcagg gactgaaatg gatggggtgg ataaatacct acaccggcga acctacatac      180

gccgacgctt ttaaagggcg agtcactatg acgcgcgata ccagcatatc caccgcatac      240

atggagctgt cccgactccg gtcagacgac acggctgtct actattgtgc tcgggactat      300

ggcgattatg gcatggacta ctggggtcag ggtacgactg taacagttag tagtggtgga      360

ggcggcagtg gcgggggggg aagcggagga gggggttctg gtgacatagt tatgacccaa      420

tccccagata gtttggcggt ttctctgggc gagagggcaa cgattaattg tcgcgcatca      480

aagagcgttt caacgagcgg atattctttt atgcattggt accagcaaaa acccggacaa      540

ccgccgaagc tgctgatcta cttggcttca aatcttgagt ctggggtgcc ggaccgattt      600

tctggtagtg gaagcggaac tgactttacg ctcacgatca gttcactgca ggctgaggat      660

gtagcggtct attattgcca gcacagtaga gaagtcccct ggaccttcgg tcaaggcacg      720

aaagtagaaa ttaaa                                                       735


<210>  50
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70B scFv amino acid sequence

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Ala Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Asp Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser 
    130                 135                 140                 


Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser 
145                 150                 155                 160 


Lys Ser Val Ser Thr Ser Gly Tyr Ser Phe Met His Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Gln His Ser Arg Glu Val Pro Trp Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  51
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VH

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Ala Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Asp Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  52
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VL

<400>  52

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  53
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  53

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


<210>  54
<211>  4688
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA rAAV

<400>  54
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgagatg taaggagctg ctgtgacttg ctcaaggcct      180

tatatcgagt aaacggtagt gctggggctt agacgcaggt gttctgattt atagttcaaa      240

acctctatca atgagagagc aatctcctgg taatgtgata gatttcccaa cttaatgcca      300

acataccata aacctcccat tctgctaatg cccagcctaa gttggggaga ccactccaga      360

ttccaagatg tacagtttgc tttgctgggc ctttttccca tgcctgcctt tactctgcca      420

gagttatatt gctggggttt tgaagaagat cctattaaat aaaagaataa gcagtattat      480

taagtagccc tgcatttcag gtttccttga gtggcaggcc aggcctggcc gtgaacgttc      540

actgaaatca tggcctcttg gccaagattg atagcttgtg cctgtccctg agtcccagtc      600

catcacgagc agctggtttc taagatgcta tttcccgtat aaagcatgag accgtgactt      660

gccagcccca cagagccccg cccttgtcca tcactggcat ctggactcca gcctgggttg      720

gggcaaagag ggaaatgaga tcatgtccta accctgatcc tcttgtccca cagatatcca      780

gaaccctgac cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg      840

cctattcacc gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta      900

tatcacagac aaaactgtgc tagacatgag gtctatggac ttcaggctcc ggtgcccgtc      960

agtgggcaga gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt     1020

gaaccggtgc ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc     1080

tccgcctttt tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg     1140

ttctttttcg caacgggttt gccgccagaa cacaggtaag tgccgtgtgt ggttcccgcg     1200

ggcctggcct ctttacgggt tatggccctt gcgtgccttg aattacttcc actggctgca     1260

gtacgtgatt cttgatcccg agcttcgggt tggaagtggg tgggagagtt cgaggccttg     1320

cgcttaagga gccccttcgc ctcgtgcttg agttgaggcc tggcctgggc gctggggccg     1380

ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct gctttcgata agtctctagc     1440

catttaaaat ttttgatgac ctgctgcgac gctttttttc tggcaagata gtcttgtaaa     1500

tgcgggccaa gatctgcaca ctggtatttc ggtttttggg gccgcgggcg gcgacggggc     1560

ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg cgagcgcggc caccgagaat     1620

cggacggggg tagtctcaag ctggccggcc tgctctggtg cctggcctcg cgccgccgtg     1680

tatcgccccg ccctgggcgg caaggctggc ccggtcggca ccagttgcgt gagcggaaag     1740

atggccgctt cccggccctg ctgcagggag ctcaaaatgg aggacgcggc gctcgggaga     1800

gcgggcgggt gagtcaccca cacaaaggaa aagggccttt ccgtcctcag ccgtcgcttc     1860

atgtgactcc acggagtacc gggcgccgtc caggcacctc gattagttct cgagcttttg     1920

gagtacgtcg tctttaggtt ggggggaggg gttttatgcg atggagtttc cccacactga     1980

gtgggtggag actgaagtta ggccagcttg gcacttgatg taattctcct tggaatttgc     2040

cctttttgag tttggatctt ggttcattct caagcctcag acagtggttc aaagtttttt     2100

tcttccattt caggtgtcgt gaccaccatg gcgcttccgg tgacagcact gctcctcccc     2160

ttggcgctgt tgctccacgc agcaaggccg caggtgcagc tggtgcagag cggagccgag     2220

ctcaagaagc ccggagcctc cgtgaaggtg agctgcaagg ccagcggcaa caccctgacc     2280

aactacgtga tccactgggt gagacaagcc cccggccaaa ggctggagtg gatgggctac     2340

atcctgccct acaacgacct gaccaagtac agccagaagt tccagggcag ggtgaccatc     2400

accagggata agagcgcctc caccgcctat atggagctga gcagcctgag gagcgaggac     2460

accgctgtgt actactgtac aaggtgggac tgggacggct tctttgaccc ctggggccag     2520

ggcacaacag tgaccgtcag cagcggcggc ggaggcagcg gcggcggcgg cagcggcgga     2580

ggcggaagcg aaatcgtgat gacccagagc cccgccacac tgagcgtgag ccctggcgag     2640

agggccagca tctcctgcag ggctagccaa agcctggtgc acagcaacgg caacacccac     2700

ctgcactggt accagcagag acccggacag gctcccaggc tgctgatcta cagcgtgagc     2760

aacaggttct ccgaggtgcc tgccaggttt agcggcagcg gaagcggcac cgactttacc     2820

ctgaccatca gcagcgtgga gtccgaggac ttcgccgtgt attactgcag ccagaccagc     2880

cacatccctt acaccttcgg cggcggcacc aagctggaga tcaaaagtgc tgctgccttt     2940

gtcccggtat ttctcccagc caaaccgacc acgactcccg ccccgcgccc tccgacaccc     3000

gctcccacca tcgcctctca acctcttagt cttcgccccg aggcatgccg acccgccgcc     3060

gggggtgctg ttcatacgag gggcttggac ttcgcttgtg atatttacat ttgggctccg     3120

ttggcgggta cgtgcggcgt ccttttgttg tcactcgtta ttactttgta ttgtaatcac     3180

aggaatcgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     3240

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     3300

ggaggatgtg aactgcgagt gaagttttcc cgaagcgcag acgctccggc atatcagcaa     3360

ggacagaatc agctgtataa cgaactgaat ttgggacgcc gcgaggagta tgacgtgctt     3420

gataaacgcc gggggagaga cccggaaatg gggggtaaac cccgaagaaa gaatccccaa     3480

gaaggactct acaatgaact ccagaaggat aagatggcgg aggcctactc agaaataggt     3540

atgaagggcg aacgacgacg gggaaaaggt cacgatggcc tctaccaagg gttgagtacg     3600

gcaaccaaag atacgtacga tgcactgcat atgcaggccc tgcctcccag ataataataa     3660

aatcgctatc catcgaagat ggatgtgtgt tggttttttg tgtgtggagc aacaaatctg     3720

actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc ttcttcccca     3780

gcccaggtaa gggcagcttt ggtgccttcg caggctgttt ccttgcttca ggaatggcca     3840

ggttctgccc agagctctgg tcaatgatgt ctaaaactcc tctgattggt ggtctcggcc     3900

ttatccattg ccaccaaaac cctcttttta ctaagaaaca gtgagccttg ttctggcagt     3960

ccagagaatg acacgggaaa aaagcagatg aagagaaggt ggcaggagag ggcacgtggc     4020

ccagcctcag tctctccaac tgagttcctg cctgcctgcc tttgctcaga ctgtttgccc     4080

cttactgctc ttctaggcct cattctaagc cccttctcca agttgcctct ccttatttct     4140

ccctgtctgc caaaaaatct ttcccagctc actaagtcag tctcacgcag tcactcatta     4200

acccaccaat cactgattgt gccggcacat gaatgcacca ggtgttgaag tggaggaatt     4260

aaaaagtcag atgaggggtg tgcccagagg aagcaccatt ctagttgggg gagcccatct     4320

gtcagctggg aaaagtccaa ataacttcag attggaatgt gttttaactc agggttgaga     4380

aaacagctac cttcaggaca aaagtcaggg aagggctctc tgaagaaatg ctacttgaag     4440

ataccagccc taccaagggc agggagagga ccctatagag gcctgggaca ggagctcaat     4500

gagaaaggta accacgtgcg gaccgaggct gcagcgtcgt cctccctagg aacccctagt     4560

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     4620

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg     4680

cctgcagg                                                              4688


<210>  55
<211>  4364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA  RHA to LHA

<400>  55
gagatgtaag gagctgctgt gacttgctca aggccttata tcgagtaaac ggtagtgctg       60

gggcttagac gcaggtgttc tgatttatag ttcaaaacct ctatcaatga gagagcaatc      120

tcctggtaat gtgatagatt tcccaactta atgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg ccgtgtacca      660

gctgagagac tctaaatcca gtgacaagtc tgtctgccta ttcaccgatt ttgattctca      720

aacaaatgtg tcacaaagta aggattctga tgtgtatatc acagacaaaa ctgtgctaga      780

catgaggtct atggacttca ggctccggtg cccgtcagtg ggcagagcgc acatcgccca      840

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc      900

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg      960

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     1020

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     1080

gcccttgcgt gccttgaatt acttccactg gctgcagtac gtgattcttg atcccgagct     1140

tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc cttcgcctcg     1200

tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct     1260

tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacctgc     1320

tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc tgcacactgg     1380

tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc gcacatgttc     1440

ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg     1500

ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag     1560

gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc     1620

agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca     1680

aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc     1740

gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt taggttgggg     1800

ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc     1860

agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg gatcttggtt     1920

cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg tgtcgtgacc     1980

accatggcgc ttccggtgac agcactgctc ctccccttgg cgctgttgct ccacgcagca     2040

aggccgcagg tgcagctggt gcagagcgga gccgagctca agaagcccgg agcctccgtg     2100

aaggtgagct gcaaggccag cggcaacacc ctgaccaact acgtgatcca ctgggtgaga     2160

caagcccccg gccaaaggct ggagtggatg ggctacatcc tgccctacaa cgacctgacc     2220

aagtacagcc agaagttcca gggcagggtg accatcacca gggataagag cgcctccacc     2280

gcctatatgg agctgagcag cctgaggagc gaggacaccg ctgtgtacta ctgtacaagg     2340

tgggactggg acggcttctt tgacccctgg ggccagggca caacagtgac cgtcagcagc     2400

ggcggcggag gcagcggcgg cggcggcagc ggcggaggcg gaagcgaaat cgtgatgacc     2460

cagagccccg ccacactgag cgtgagccct ggcgagaggg ccagcatctc ctgcagggct     2520

agccaaagcc tggtgcacag caacggcaac acccacctgc actggtacca gcagagaccc     2580

ggacaggctc ccaggctgct gatctacagc gtgagcaaca ggttctccga ggtgcctgcc     2640

aggtttagcg gcagcggaag cggcaccgac tttaccctga ccatcagcag cgtggagtcc     2700

gaggacttcg ccgtgtatta ctgcagccag accagccaca tcccttacac cttcggcggc     2760

ggcaccaagc tggagatcaa aagtgctgct gcctttgtcc cggtatttct cccagccaaa     2820

ccgaccacga ctcccgcccc gcgccctccg acacccgctc ccaccatcgc ctctcaacct     2880

cttagtcttc gccccgaggc atgccgaccc gccgccgggg gtgctgttca tacgaggggc     2940

ttggacttcg cttgtgatat ttacatttgg gctccgttgg cgggtacgtg cggcgtcctt     3000

ttgttgtcac tcgttattac tttgtattgt aatcacagga atcgcaaacg gggcagaaag     3060

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     3120

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gcgagtgaag     3180

ttttcccgaa gcgcagacgc tccggcatat cagcaaggac agaatcagct gtataacgaa     3240

ctgaatttgg gacgccgcga ggagtatgac gtgcttgata aacgccgggg gagagacccg     3300

gaaatggggg gtaaaccccg aagaaagaat ccccaagaag gactctacaa tgaactccag     3360

aaggataaga tggcggaggc ctactcagaa ataggtatga agggcgaacg acgacgggga     3420

aaaggtcacg atggcctcta ccaagggttg agtacggcaa ccaaagatac gtacgatgca     3480

ctgcatatgc aggccctgcc tcccagataa taataaaatc gctatccatc gaagatggat     3540

gtgtgttggt tttttgtgtg tggagcaaca aatctgactt tgcatgtgca aacgccttca     3600

acaacagcat tattccagaa gacaccttct tccccagccc aggtaagggc agctttggtg     3660

ccttcgcagg ctgtttcctt gcttcaggaa tggccaggtt ctgcccagag ctctggtcaa     3720

tgatgtctaa aactcctctg attggtggtc tcggccttat ccattgccac caaaaccctc     3780

tttttactaa gaaacagtga gccttgttct ggcagtccag agaatgacac gggaaaaaag     3840

cagatgaaga gaaggtggca ggagagggca cgtggcccag cctcagtctc tccaactgag     3900

ttcctgcctg cctgcctttg ctcagactgt ttgcccctta ctgctcttct aggcctcatt     3960

ctaagcccct tctccaagtt gcctctcctt atttctccct gtctgccaaa aaatctttcc     4020

cagctcacta agtcagtctc acgcagtcac tcattaaccc accaatcact gattgtgccg     4080

gcacatgaat gcaccaggtg ttgaagtgga ggaattaaaa agtcagatga ggggtgtgcc     4140

cagaggaagc accattctag ttgggggagc ccatctgtca gctgggaaaa gtccaaataa     4200

cttcagattg gaatgtgttt taactcaggg ttgagaaaac agctaccttc aggacaaaag     4260

tcagggaagg gctctctgaa gaaatgctac ttgaagatac cagccctacc aagggcaggg     4320

agaggaccct atagaggcct gggacaggag ctcaatgaga aagg                      4364


<210>  56
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA CAR nucleotide sequence

<400>  56
atggcgcttc cggtgacagc actgctcctc cccttggcgc tgttgctcca cgcagcaagg       60

ccgcaggtgc agctggtgca gagcggagcc gagctcaaga agcccggagc ctccgtgaag      120

gtgagctgca aggccagcgg caacaccctg accaactacg tgatccactg ggtgagacaa      180

gcccccggcc aaaggctgga gtggatgggc tacatcctgc cctacaacga cctgaccaag      240

tacagccaga agttccaggg cagggtgacc atcaccaggg ataagagcgc ctccaccgcc      300

tatatggagc tgagcagcct gaggagcgag gacaccgctg tgtactactg tacaaggtgg      360

gactgggacg gcttctttga cccctggggc cagggcacaa cagtgaccgt cagcagcggc      420

ggcggaggca gcggcggcgg cggcagcggc ggaggcggaa gcgaaatcgt gatgacccag      480

agccccgcca cactgagcgt gagccctggc gagagggcca gcatctcctg cagggctagc      540

caaagcctgg tgcacagcaa cggcaacacc cacctgcact ggtaccagca gagacccgga      600

caggctccca ggctgctgat ctacagcgtg agcaacaggt tctccgaggt gcctgccagg      660

tttagcggca gcggaagcgg caccgacttt accctgacca tcagcagcgt ggagtccgag      720

gacttcgccg tgtattactg cagccagacc agccacatcc cttacacctt cggcggcggc      780

accaagctgg agatcaaaag tgctgctgcc tttgtcccgg tatttctccc agccaaaccg      840

accacgactc ccgccccgcg ccctccgaca cccgctccca ccatcgcctc tcaacctctt      900

agtcttcgcc ccgaggcatg ccgacccgcc gccgggggtg ctgttcatac gaggggcttg      960

gacttcgctt gtgatattta catttgggct ccgttggcgg gtacgtgcgg cgtccttttg     1020

ttgtcactcg ttattacttt gtattgtaat cacaggaatc gcaaacgggg cagaaagaaa     1080

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1140

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgcg agtgaagttt     1200

tcccgaagcg cagacgctcc ggcatatcag caaggacaga atcagctgta taacgaactg     1260

aatttgggac gccgcgagga gtatgacgtg cttgataaac gccgggggag agacccggaa     1320

atggggggta aaccccgaag aaagaatccc caagaaggac tctacaatga actccagaag     1380

gataagatgg cggaggccta ctcagaaata ggtatgaagg gcgaacgacg acggggaaaa     1440

ggtcacgatg gcctctacca agggttgagt acggcaacca aagatacgta cgatgcactg     1500

catatgcagg ccctgcctcc caga                                            1524


<210>  57
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA CAR amino acid sequence

<400>  57

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asn 
        35                  40                  45              


Thr Leu Thr Asn Tyr Val Ile His Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Arg Leu Glu Trp Met Gly Tyr Ile Leu Pro Tyr Asn Asp Leu Thr Lys 
65                  70                  75                  80  


Tyr Ser Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Lys Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Trp Asp Trp Asp Gly Phe Phe Asp Pro 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Ser Ile Ser 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr His Leu 
            180                 185                 190         


His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        195                 200                 205             


Ser Val Ser Asn Arg Phe Ser Glu Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Glu Ser Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Ser Gln Thr Ser His Ile Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Ala Ala Ala Phe Val 
            260                 265                 270         


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        275                 280                 285             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    290                 295                 300                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
305                 310                 315                 320 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                325                 330                 335     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
            340                 345                 350         


Asn Arg Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        355                 360                 365             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    370                 375                 380                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
385                 390                 395                 400 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                405                 410                 415     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            420                 425                 430         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        435                 440                 445             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    450                 455                 460                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
465                 470                 475                 480 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                485                 490                 495     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505             


<210>  58
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA scFv nucleotide sequence

<400>  58
caggtgcagc tggtgcagag cggagccgag ctcaagaagc ccggagcctc cgtgaaggtg       60

agctgcaagg ccagcggcaa caccctgacc aactacgtga tccactgggt gagacaagcc      120

cccggccaaa ggctggagtg gatgggctac atcctgccct acaacgacct gaccaagtac      180

agccagaagt tccagggcag ggtgaccatc accagggata agagcgcctc caccgcctat      240

atggagctga gcagcctgag gagcgaggac accgctgtgt actactgtac aaggtgggac      300

tgggacggct tctttgaccc ctggggccag ggcacaacag tgaccgtcag cagcggcggc      360

ggaggcagcg gcggcggcgg cagcggcgga ggcggaagcg aaatcgtgat gacccagagc      420

cccgccacac tgagcgtgag ccctggcgag agggccagca tctcctgcag ggctagccaa      480

agcctggtgc acagcaacgg caacacccac ctgcactggt accagcagag acccggacag      540

gctcccaggc tgctgatcta cagcgtgagc aacaggttct ccgaggtgcc tgccaggttt      600

agcggcagcg gaagcggcac cgactttacc ctgaccatca gcagcgtgga gtccgaggac      660

ttcgccgtgt attactgcag ccagaccagc cacatccctt acaccttcgg cggcggcacc      720

aagctggaga tcaaa                                                       735


<210>  59
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA scFv amino acid sequence

<400>  59

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asn Thr Leu Thr Asn Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Leu Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Asp Trp Asp Gly Phe Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Val Ser Pro Gly Glu Arg Ala Ser Ile Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Leu Val His Ser Asn Gly Asn Thr His Leu His Trp Tyr Gln Gln 
                165                 170                 175     


Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ser Val Ser Asn Arg 
            180                 185                 190         


Phe Ser Glu Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Val Glu Ser Glu Asp Phe Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ser Gln Thr Ser His Ile Pro Tyr Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys 
                245 


<210>  60
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VH

<400>  60

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asn Thr Leu Thr Asn Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Leu Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Asp Trp Asp Gly Phe Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  61
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VL

<400>  61

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Ser Ile Ser Cys Arg Ala Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr His Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Ser Val Ser Asn Arg Phe Ser Glu Val Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Val Glu Ser Glu Asp Phe Ala Val Tyr Tyr Cys Ser Gln Thr 
                85                  90                  95      


Ser His Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VL CDR1 (Kabat)

<400>  62

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Phe Met His 
1               5                   10                  15  


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VL CDR1 (Chothia)

<400>  63

Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Phe 
1               5                   10      


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VL CDR2 (Kabat)

<400>  64

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  65
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VL CDR2 (Chothia)

<400>  65

Leu Ala Ser 
1           


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VL CDR3 (Kabat)

<400>  66

Gln His Ser Arg Glu Val Pro Trp Thr 
1               5                   


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VL CDR3 (Chothia)

<400>  67

Ser Arg Glu Val Pro Trp 
1               5       


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VH CDR1 (Kabat)

<400>  68

Asn Tyr Gly Met Asn 
1               5   


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VH CDR1 (Chothia)

<400>  69

Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   10  


<210>  70
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VH CDR2 (Kabat)

<400>  70

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Ala Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VH CDR2 (Chothia)

<400>  71

Asn Thr Tyr Thr Gly Glu 
1               5       


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VH CDR3 (Kabat)

<400>  72

Asp Tyr Gly Asp Tyr Gly Met Asp Tyr 
1               5                   


<210>  73
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 VH CDR3 (Chothia)

<400>  73

Cys Ala Arg Asp Tyr Gly Asp Tyr Gly Met Asp Tyr Trp Gly 
1               5                   10                  


<210>  74
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VL CDR1 (Kabat)

<400>  74

Arg Ala Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr His Leu His 
1               5                   10                  15      


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VL CDR1 (Chothia)

<400>  75

Arg Ala Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr His Leu His 
1               5                   10                  15      


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VL CDR2 (Kabat)

<400>  76

Ser Val Ser Asn Arg 
1               5   


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VL CDR2 (Chothia)

<400>  77

Ser Val Ser Asn Arg 
1               5   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VL CDR3 (Kabat)

<400>  78

Ser Gln Thr Ser His Ile Pro Tyr Thr 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VL CDR3 (Chothia)

<400>  79

Ser Gln Thr Ser His Ile Pro Tyr Thr 
1               5                   


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VH CDR1 (Kabat)

<400>  80

Asn Tyr Val Ile His 
1               5   


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VH CDR1 (Chothia)

<400>  81

Gly Asn Thr Leu Thr Asn Tyr 
1               5           


<210>  82
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VH CDR2 (Kabat)

<400>  82

Tyr Ile Leu Pro Tyr Asn Asp Leu Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VH CDR2 (Chothia)

<400>  83

Leu Pro Tyr Asn Asp Leu 
1               5       


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VH CDR3 (Kabat)

<400>  84

Trp Asp Trp Asp Gly Phe Phe Asp Pro 
1               5                   


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA VH CDR3 (Chothia)

<400>  85

Trp Asp Trp Asp Gly Phe Phe Asp Pro 
1               5                   


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC target sequence

<400>  86
agagcaacag tgctgtggcc                                                   20


<210>  87
<211>  4691
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD33 CAR rAAV

<400>  87
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgagatg taaggagctg ctgtgacttg ctcaaggcct      180

tatatcgagt aaacggtagt gctggggctt agacgcaggt gttctgattt atagttcaaa      240

acctctatca atgagagagc aatctcctgg taatgtgata gatttcccaa cttaatgcca      300

acataccata aacctcccat tctgctaatg cccagcctaa gttggggaga ccactccaga      360

ttccaagatg tacagtttgc tttgctgggc ctttttccca tgcctgcctt tactctgcca      420

gagttatatt gctggggttt tgaagaagat cctattaaat aaaagaataa gcagtattat      480

taagtagccc tgcatttcag gtttccttga gtggcaggcc aggcctggcc gtgaacgttc      540

actgaaatca tggcctcttg gccaagattg atagcttgtg cctgtccctg agtcccagtc      600

catcacgagc agctggtttc taagatgcta tttcccgtat aaagcatgag accgtgactt      660

gccagcccca cagagccccg cccttgtcca tcactggcat ctggactcca gcctgggttg      720

gggcaaagag ggaaatgaga tcatgtccta accctgatcc tcttgtccca cagatatcca      780

gaaccctgac cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg      840

cctattcacc gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta      900

tatcacagac aaaactgtgc tagacatgag gtctatggac ttcaggctcc ggtgcccgtc      960

agtgggcaga gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt     1020

gaaccggtgc ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc     1080

tccgcctttt tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg     1140

ttctttttcg caacgggttt gccgccagaa cacaggtaag tgccgtgtgt ggttcccgcg     1200

ggcctggcct ctttacgggt tatggccctt gcgtgccttg aattacttcc actggctgca     1260

gtacgtgatt cttgatcccg agcttcgggt tggaagtggg tgggagagtt cgaggccttg     1320

cgcttaagga gccccttcgc ctcgtgcttg agttgaggcc tggcctgggc gctggggccg     1380

ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct gctttcgata agtctctagc     1440

catttaaaat ttttgatgac ctgctgcgac gctttttttc tggcaagata gtcttgtaaa     1500

tgcgggccaa gatctgcaca ctggtatttc ggtttttggg gccgcgggcg gcgacggggc     1560

ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg cgagcgcggc caccgagaat     1620

cggacggggg tagtctcaag ctggccggcc tgctctggtg cctggcctcg cgccgccgtg     1680

tatcgccccg ccctgggcgg caaggctggc ccggtcggca ccagttgcgt gagcggaaag     1740

atggccgctt cccggccctg ctgcagggag ctcaaaatgg aggacgcggc gctcgggaga     1800

gcgggcgggt gagtcaccca cacaaaggaa aagggccttt ccgtcctcag ccgtcgcttc     1860

atgtgactcc acggagtacc gggcgccgtc caggcacctc gattagttct cgagcttttg     1920

gagtacgtcg tctttaggtt ggggggaggg gttttatgcg atggagtttc cccacactga     1980

gtgggtggag actgaagtta ggccagcttg gcacttgatg taattctcct tggaatttgc     2040

cctttttgag tttggatctt ggttcattct caagcctcag acagtggttc aaagtttttt     2100

tcttccattt caggtgtcgt gaccaccatg gcgcttccgg tgacagcact gctcctcccc     2160

ttggcgctgt tgctccacgc agcaaggccg gaaatcgtcc tcacacaatc cccggggagc     2220

ctcgcagtca gtcctgggga acgagtcact atgagctgca aatccagtca gagtgttttt     2280

ttctcaagta gccagaagaa ctacctcgca tggtaccaac aaataccggg gcaatctccc     2340

cgcttgctta tatactgggc aagtacccgc gaatccggcg taccggatcg attcacggga     2400

tctgggtcag gtactgattt cactttgact atcagctctg ttcagcctga agatttggca     2460

atttactact gtcaccaata cttgagtagc cgaactttcg gccagggcac gaagctcgaa     2520

atcaagggcg gagggggagg ttctggtggg ggcggttctg gcggtggagg aagccaagta     2580

cagttgcaac agccaggggc ggaggtcgta aaacctgggg cgtctgtcaa gatgagctgt     2640

aaagcaagtg gatacacctt cacctcctac tatatacatt ggattaagca aactccgggt     2700

caggggctgg aatgggttgg cgttatatac cccgggaacg atgatatatc atacaaccaa     2760

aaatttcaag gcaaggcgac tctgactgcc gataagagta gcacaacagc ttacatgcag     2820

ctttcttccc tgaccagcga agattcagca gtttactact gcgctcggga agtgcgcctg     2880

cgatactttg atgtctgggg tcaaggaact acagttactg tatcaagcag tgctgctgcc     2940

tttgtcccgg tatttctccc agccaaaccg accacgactc ccgccccgcg ccctccgaca     3000

cccgctccca ccatcgcctc tcaacctctt agtcttcgcc ccgaggcatg ccgacccgcc     3060

gccgggggtg ctgttcatac gaggggcttg gacttcgctt gtgatattta catttgggct     3120

ccgttggcgg gtacgtgcgg cgtccttttg ttgtcactcg ttattacttt gtattgtaat     3180

cacaggaatc gcaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     3240

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     3300

gaaggaggat gtgaactgcg agtgaagttt tcccgaagcg cagacgctcc ggcatatcag     3360

caaggacaga atcagctgta taacgaactg aatttgggac gccgcgagga gtatgacgtg     3420

cttgataaac gccgggggag agacccggaa atggggggta aaccccgaag aaagaatccc     3480

caagaaggac tctacaatga actccagaag gataagatgg cggaggccta ctcagaaata     3540

ggtatgaagg gcgaacgacg acggggaaaa ggtcacgatg gcctctacca agggttgagt     3600

acggcaacca aagatacgta cgatgcactg catatgcagg ccctgcctcc cagataataa     3660

taaaatcgct atccatcgaa gatggatgtg tgttggtttt ttgtgtgtgg agcaacaaat     3720

ctgactttgc atgtgcaaac gccttcaaca acagcattat tccagaagac accttcttcc     3780

ccagcccagg taagggcagc tttggtgcct tcgcaggctg tttccttgct tcaggaatgg     3840

ccaggttctg cccagagctc tggtcaatga tgtctaaaac tcctctgatt ggtggtctcg     3900

gccttatcca ttgccaccaa aaccctcttt ttactaagaa acagtgagcc ttgttctggc     3960

agtccagaga atgacacggg aaaaaagcag atgaagagaa ggtggcagga gagggcacgt     4020

ggcccagcct cagtctctcc aactgagttc ctgcctgcct gcctttgctc agactgtttg     4080

ccccttactg ctcttctagg cctcattcta agccccttct ccaagttgcc tctccttatt     4140

tctccctgtc tgccaaaaaa tctttcccag ctcactaagt cagtctcacg cagtcactca     4200

ttaacccacc aatcactgat tgtgccggca catgaatgca ccaggtgttg aagtggagga     4260

attaaaaagt cagatgaggg gtgtgcccag aggaagcacc attctagttg ggggagccca     4320

tctgtcagct gggaaaagtc caaataactt cagattggaa tgtgttttaa ctcagggttg     4380

agaaaacagc taccttcagg acaaaagtca gggaagggct ctctgaagaa atgctacttg     4440

aagataccag ccctaccaag ggcagggaga ggaccctata gaggcctggg acaggagctc     4500

aatgagaaag gtaaccacgt gcggaccgag gctgcagcgt cgtcctccct aggaacccct     4560

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     4620

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag     4680

ctgcctgcag g                                                          4691


<210>  88
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: signal peptide

<400>  88

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  89
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: signal peptide

<400>  89

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  90
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD8a transmembrane domain

<400>  90

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Arg 
                


<210>  91
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T1) spacer

<400>  91
ucaccaagcc cgcgaccaau                                                   20


<210>  92
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T3) spacer

<400>  92
aucaccaagc ccgcgaccaa                                                   20


<210>  93
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T4) spacer

<400>  93
cggugcggcg caggcccuau                                                   20


<210>  94
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T7) spacer

<400>  94
gcuuuggucc cauuggucgc                                                   20


<210>  95
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T8) spacer

<400>  95
gcccgcagga cgcacccaua                                                   20


<210>  96
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T10) spacer

<400>  96
gugcauccag cgcuucgcac                                                   20


<210>  97
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E3_T1) spacer

<400>  97
cagcuacgua uccaucguga                                                   20


<210>  98
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC spacer

<400>  98
agagcaacag ugcuguggcc                                                   20


<210>  99
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: b2M sgRNA spacer

<400>  99
gcuacucucu cuuucuggcc                                                   20


<210>  100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: PD-1 sgRNA spacer

<400>  100
cugcagcuuc uccaacacau                                                   20


<210>  101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T3) spacer


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<400>  101
ucaccaagcc cgcgaccaau                                                   20


<210>  102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T4) spacer


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<400>  102
aucaccaagc ccgcgaccaa                                                   20


<210>  103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T7) spacer


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<400>  103
cggugcggcg caggcccuau                                                   20


<210>  104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T8) spacer


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<400>  104
gcuuuggucc cauuggucgc                                                   20


<210>  105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T10) spacer


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<400>  105
gcccgcagga cgcacccaua                                                   20


<210>  106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E3_T10) spacer


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<400>  106
gugcauccag cgcuucgcac                                                   20


<210>  107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T3) spacer


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<400>  107
cagcuacgua uccaucguga                                                   20


<210>  108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC spacer


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<400>  108
agagcaacag ugcuguggcc                                                   20


<210>  109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: b2M sgRNA spacer


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<400>  109
gcuacucucu cuuucuggcc                                                   20


<210>  110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: PD-1 sgRNA spacer


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-methyl phosphorothioate

<400>  110
cugcagcuuc uccaacacau                                                   20


<210>  111
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T1) with PAM

<400>  111
tcaccaagcc cgcgaccaat ggg                                               23


<210>  112
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T3) with PAM

<400>  112
atcaccaagc ccgcgaccaa tgg                                               23


<210>  113
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T4) with PAM

<400>  113
cggtgcggcg caggccctat ggg                                               23


<210>  114
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T7) with PAM

<400>  114
gctttggtcc cattggtcgc ggg                                               23


<210>  115
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T8) with PAM

<400>  115
gcccgcagga cgcacccata ggg                                               23


<210>  116
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T10) with PAM

<400>  116
gtgcatccag cgcttcgcac agg                                               23


<210>  117
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E3_T1) with PAM

<400>  117
cagctacgta tccatcgtga tgg                                               23


<210>  118
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC sgRNA with PAM

<400>  118
agagcaacag tgctgtggcc tgg                                               23


<210>  119
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: b2M sgRNA with PAM

<400>  119
gctactctct ctttctggcc tgg                                               23


<210>  120
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: PD-1 sgRNA with PAM

<400>  120
ctgcagcttc tccaacacat cgg                                               23


<210>  121
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD28 nucleotide sequence

<400>  121
tcaaagcgga gtaggttgtt gcattccgat tacatgaata tgactcctcg ccggcctggg       60

ccgacaagaa aacattacca accctatgcc cccccacgag acttcgctgc gtacaggtcc      120


<210>  122
<211>  800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC-LHA

<400>  122
gagatgtaag gagctgctgt gacttgctca aggccttata tcgagtaaac ggtagtgctg       60

gggcttagac gcaggtgttc tgatttatag ttcaaaacct ctatcaatga gagagcaatc      120

tcctggtaat gtgatagatt tcccaactta atgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg ccgtgtacca      660

gctgagagac tctaaatcca gtgacaagtc tgtctgccta ttcaccgatt ttgattctca      720

aacaaatgtg tcacaaagta aggattctga tgtgtatatc acagacaaaa ctgtgctaga      780

catgaggtct atggacttca                                                  800


<210>  123
<211>  1178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: EF1-alpha promoter

<400>  123
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg       60

ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt      120

gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca      180

gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc      240

gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt      300

acttccactg gctgcagtac gtgattcttg atcccgagct tcgggttgga agtgggtggg      360

agagttcgag gccttgcgct taaggagccc cttcgcctcg tgcttgagtt gaggcctggc      420

ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt      480

tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt tttttctggc      540

aagatagtct tgtaaatgcg ggccaagatc tgcacactgg tatttcggtt tttggggccg      600

cgggcggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag      660

cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg      720

gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg tcggcaccag      780

ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc agggagctca aaatggagga      840

cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg gcctttccgt      900

cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg cacctcgatt      960

agttctcgag cttttggagt acgtcgtctt taggttgggg ggaggggttt tatgcgatgg     1020

agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac ttgatgtaat     1080

tctccttgga atttgccctt tttgagtttg gatcttggtt cattctcaag cctcagacag     1140

tggttcaaag tttttttctt ccatttcagg tgtcgtga                             1178


<210>  124
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Synthetic poly(A) signal

<400>  124
aataaaatcg ctatccatcg aagatggatg tgtgttggtt ttttgtgtg                   49


<210>  125
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRACRHA

<400>  125
tggagcaaca aatctgactt tgcatgtgca aacgccttca acaacagcat tattccagaa       60

gacaccttct tccccagccc aggtaagggc agctttggtg ccttcgcagg ctgtttcctt      120

gcttcaggaa tggccaggtt ctgcccagag ctctggtcaa tgatgtctaa aactcctctg      180

attggtggtc tcggccttat ccattgccac caaaaccctc tttttactaa gaaacagtga      240

gccttgttct ggcagtccag agaatgacac gggaaaaaag cagatgaaga gaaggtggca      300

ggagagggca cgtggcccag cctcagtctc tccaactgag ttcctgcctg cctgcctttg      360

ctcagactgt ttgcccctta ctgctcttct aggcctcatt ctaagcccct tctccaagtt      420

gcctctcctt atttctccct gtctgccaaa aaatctttcc cagctcacta agtcagtctc      480

acgcagtcac tcattaaccc accaatcact gattgtgccg gcacatgaat gcaccaggtg      540

ttgaagtgga ggaattaaaa agtcagatga ggggtgtgcc cagaggaagc accattctag      600

ttgggggagc ccatctgtca gctgggaaaa gtccaaataa cttcagattg gaatgtgttt      660

taactcaggg ttgagaaaac agctaccttc aggacaaaag tcagggaagg gctctctgaa      720

gaaatgctac ttgaagatac cagccctacc aagggcaggg agaggaccct atagaggcct      780

gggacaggag ctcaatgaga aagg                                             804


<210>  126
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD8a transmembrane

<400>  126

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr 
            20              


<210>  127
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 forward primer

<400>  127
tcgtcggcag cgtcagatgt gtataagaga cagcccaact tttccatctc aactcacccc       60

aagtg                                                                   65


<210>  128
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 reverse primer

<400>  128
gtctcgtggg ctcggagatg tgtataagag acagcccctc ctgcgctagc gga              53


<210>  129
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 Indel

<400>  129
cacaccacga ggcagatcac caagcccgcg caatgggacc aaagcagccc gcaggacg         58


<210>  130
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 Indel

<400>  130
cacaccacga ggcagatcac caagcccgcg aaccaatggg accaaagcag cccgcaggac       60

g                                                                       61


<210>  131
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 Indel

<400>  131
cacaccacga ggcagatcac caatgggacc aaagcagccc gcaggacg                    48


<210>  132
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 Indel

<400>  132
cacaccacga ggcagatcac caagcccgcg ccaatgggac caaagcagcc cgcaggacg        59


<210>  133
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 Indel

<400>  133
cacaccacga ggcagatcac caagcccgca ccaatgggac caaagcagcc cgcaggacg        59


<210>  134
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 Indel

<400>  134
cacaccacga ggcagatcac caagcccgca ggacg                                  35


<210>  135
<211>  4367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD33 CAR Donor LHA to RHA 41BB costim.

<400>  135
gagatgtaag gagctgctgt gacttgctca aggccttata tcgagtaaac ggtagtgctg       60

gggcttagac gcaggtgttc tgatttatag ttcaaaacct ctatcaatga gagagcaatc      120

tcctggtaat gtgatagatt tcccaactta atgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg ccgtgtacca      660

gctgagagac tctaaatcca gtgacaagtc tgtctgccta ttcaccgatt ttgattctca      720

aacaaatgtg tcacaaagta aggattctga tgtgtatatc acagacaaaa ctgtgctaga      780

catgaggtct atggacttca ggctccggtg cccgtcagtg ggcagagcgc acatcgccca      840

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc      900

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg      960

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     1020

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     1080

gcccttgcgt gccttgaatt acttccactg gctgcagtac gtgattcttg atcccgagct     1140

tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc cttcgcctcg     1200

tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct     1260

tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacctgc     1320

tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc tgcacactgg     1380

tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc gcacatgttc     1440

ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg     1500

ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag     1560

gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc     1620

agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca     1680

aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc     1740

gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt taggttgggg     1800

ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc     1860

agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg gatcttggtt     1920

cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg tgtcgtgacc     1980

accatggcgc ttccggtgac agcactgctc ctccccttgg cgctgttgct ccacgcagca     2040

aggccggaaa tcgtcctcac acaatccccg gggagcctcg cagtcagtcc tggggaacga     2100

gtcactatga gctgcaaatc cagtcagagt gtttttttct caagtagcca gaagaactac     2160

ctcgcatggt accaacaaat accggggcaa tctccccgct tgcttatata ctgggcaagt     2220

acccgcgaat ccggcgtacc ggatcgattc acgggatctg ggtcaggtac tgatttcact     2280

ttgactatca gctctgttca gcctgaagat ttggcaattt actactgtca ccaatacttg     2340

agtagccgaa ctttcggcca gggcacgaag ctcgaaatca agggcggagg gggaggttct     2400

ggtgggggcg gttctggcgg tggaggaagc caagtacagt tgcaacagcc aggggcggag     2460

gtcgtaaaac ctggggcgtc tgtcaagatg agctgtaaag caagtggata caccttcacc     2520

tcctactata tacattggat taagcaaact ccgggtcagg ggctggaatg ggttggcgtt     2580

atataccccg ggaacgatga tatatcatac aaccaaaaat ttcaaggcaa ggcgactctg     2640

actgccgata agagtagcac aacagcttac atgcagcttt cttccctgac cagcgaagat     2700

tcagcagttt actactgcgc tcgggaagtg cgcctgcgat actttgatgt ctggggtcaa     2760

ggaactacag ttactgtatc aagcagtgct gctgcctttg tcccggtatt tctcccagcc     2820

aaaccgacca cgactcccgc cccgcgccct ccgacacccg ctcccaccat cgcctctcaa     2880

cctcttagtc ttcgccccga ggcatgccga cccgccgccg ggggtgctgt tcatacgagg     2940

ggcttggact tcgcttgtga tatttacatt tgggctccgt tggcgggtac gtgcggcgtc     3000

cttttgttgt cactcgttat tactttgtat tgtaatcaca ggaatcgcaa acggggcaga     3060

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     3120

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgcgagtg     3180

aagttttccc gaagcgcaga cgctccggca tatcagcaag gacagaatca gctgtataac     3240

gaactgaatt tgggacgccg cgaggagtat gacgtgcttg ataaacgccg ggggagagac     3300

ccggaaatgg ggggtaaacc ccgaagaaag aatccccaag aaggactcta caatgaactc     3360

cagaaggata agatggcgga ggcctactca gaaataggta tgaagggcga acgacgacgg     3420

ggaaaaggtc acgatggcct ctaccaaggg ttgagtacgg caaccaaaga tacgtacgat     3480

gcactgcata tgcaggccct gcctcccaga taataataaa atcgctatcc atcgaagatg     3540

gatgtgtgtt ggttttttgt gtgtggagca acaaatctga ctttgcatgt gcaaacgcct     3600

tcaacaacag cattattcca gaagacacct tcttccccag cccaggtaag ggcagctttg     3660

gtgccttcgc aggctgtttc cttgcttcag gaatggccag gttctgccca gagctctggt     3720

caatgatgtc taaaactcct ctgattggtg gtctcggcct tatccattgc caccaaaacc     3780

ctctttttac taagaaacag tgagccttgt tctggcagtc cagagaatga cacgggaaaa     3840

aagcagatga agagaaggtg gcaggagagg gcacgtggcc cagcctcagt ctctccaact     3900

gagttcctgc ctgcctgcct ttgctcagac tgtttgcccc ttactgctct tctaggcctc     3960

attctaagcc ccttctccaa gttgcctctc cttatttctc cctgtctgcc aaaaaatctt     4020

tcccagctca ctaagtcagt ctcacgcagt cactcattaa cccaccaatc actgattgtg     4080

ccggcacatg aatgcaccag gtgttgaagt ggaggaatta aaaagtcaga tgaggggtgt     4140

gcccagagga agcaccattc tagttggggg agcccatctg tcagctggga aaagtccaaa     4200

taacttcaga ttggaatgtg ttttaactca gggttgagaa aacagctacc ttcaggacaa     4260

aagtcaggga agggctctct gaagaaatgc tacttgaaga taccagccct accaagggca     4320

gggagaggac cctatagagg cctgggacag gagctcaatg agaaagg                   4367


<210>  136
<211>  1585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD33 CAR 41BB costim

<400>  136
ccaccatggc gcttccggtg acagcactgc tcctcccctt ggcgctgttg ctccacgcag       60

caaggccgga aatcgtcctc acacaatccc cggggagcct cgcagtcagt cctggggaac      120

gagtcactat gagctgcaaa tccagtcaga gtgttttttt ctcaagtagc cagaagaact      180

acctcgcatg gtaccaacaa ataccggggc aatctccccg cttgcttata tactgggcaa      240

gtacccgcga atccggcgta ccggatcgat tcacgggatc tgggtcaggt actgatttca      300

ctttgactat cagctctgtt cagcctgaag atttggcaat ttactactgt caccaatact      360

tgagtagccg aactttcggc cagggcacga agctcgaaat caagggcgga gggggaggtt      420

ctggtggggg cggttctggc ggtggaggaa gccaagtaca gttgcaacag ccaggggcgg      480

aggtcgtaaa acctggggcg tctgtcaaga tgagctgtaa agcaagtgga tacaccttca      540

cctcctacta tatacattgg attaagcaaa ctccgggtca ggggctggaa tgggttggcg      600

ttatataccc cgggaacgat gatatatcat acaaccaaaa atttcaaggc aaggcgactc      660

tgactgccga taagagtagc acaacagctt acatgcagct ttcttccctg accagcgaag      720

attcagcagt ttactactgc gctcgggaag tgcgcctgcg atactttgat gtctggggtc      780

aaggaactac agttactgta tcaagcagtg ctgctgcctt tgtcccggta tttctcccag      840

ccaaaccgac cacgactccc gccccgcgcc ctccgacacc cgctcccacc atcgcctctc      900

aacctcttag tcttcgcccc gaggcatgcc gacccgccgc cgggggtgct gttcatacga      960

ggggcttgga cttcgcttgt gatatttaca tttgggctcc gttggcgggt acgtgcggcg     1020

tccttttgtt gtcactcgtt attactttgt attgtaatca caggaatcgc aaacggggca     1080

gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa actactcaag     1140

aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt gaactgcgag     1200

tgaagttttc ccgaagcgca gacgctccgg catatcagca aggacagaat cagctgtata     1260

acgaactgaa tttgggacgc cgcgaggagt atgacgtgct tgataaacgc cgggggagag     1320

acccggaaat ggggggtaaa ccccgaagaa agaatcccca agaaggactc tacaatgaac     1380

tccagaagga taagatggcg gaggcctact cagaaatagg tatgaagggc gaacgacgac     1440

ggggaaaagg tcacgatggc ctctaccaag ggttgagtac ggcaaccaaa gatacgtacg     1500

atgcactgca tatgcaggcc ctgcctccca gataataata aaatcgctat ccatcgaaga     1560

tggatgtgtg ttggtttttt gtgtg                                           1585


<210>  137
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD33  scFv Linker

<400>  137

Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe Ser 
            20                  25                  30          


Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
145                 150                 155                 160 


Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val 
                165                 170                 175     


Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe 
            180                 185                 190         


Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
        195                 200                 205             


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Thr Val Thr Val Ser Ser 
                245     


<210>  138
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD33  scFv

<400>  138
gaaatcgtcc tcacacaatc cccggggagc ctcgcagtca gtcctgggga acgagtcact       60

atgagctgca aatccagtca gagtgttttt ttctcaagta gccagaagaa ctacctcgca      120

tggtaccaac aaataccggg gcaatctccc cgcttgctta tatactgggc aagtacccgc      180

gaatccggcg taccggatcg attcacggga tctgggtcag gtactgattt cactttgact      240

atcagctctg ttcagcctga agatttggca atttactact gtcaccaata cttgagtagc      300

cgaactttcg gccagggcac gaagctcgaa atcaagggcg gagggggagg ttctggtggg      360

ggcggttctg gcggtggagg aagccaagta cagttgcaac agccaggggc ggaggtcgta      420

aaacctgggg cgtctgtcaa gatgagctgt aaagcaagtg gatacacctt cacctcctac      480

tatatacatt ggattaagca aactccgggt caggggctgg aatgggttgg cgttatatac      540

cccgggaacg atgatatatc atacaaccaa aaatttcaag gcaaggcgac tctgactgcc      600

gataagagta gcacaacagc ttacatgcag ctttcttccc tgaccagcga agattcagca      660

gtttactact gcgctcggga agtgcgcctg cgatactttg atgtctgggg tcaaggaact      720

acagttactg tatcaagc                                                    738


<210>  139
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD33 CAR 41BB costim.

<400>  139

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu 
            20                  25                  30          


Ala Val Ser Pro Gly Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Val Phe Phe Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Ile Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile 
            100                 105                 110         


Tyr Tyr Cys His Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Ser Tyr Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Val Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser 
        195                 200                 205             


Tyr Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
    210                 215                 220                 


Ser Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val 
                245                 250                 255     


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ser Ala Ala Ala Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Asn Arg Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  140
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD33 antibody VH CDRs

<400>  140

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  141
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: antiCD33 antibody VL CDRs

<400>  141

Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe Ser 
            20                  25                  30          


Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  142
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD33 antibody  VH CDR1 (Kabat)

<400>  142

Ser Tyr Tyr Ile His 
1               5   


<210>  143
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD33 antibody  VH CDR2 (Kabat)

<400>  143

Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  144
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD33 antibody  VH CDR3 (Kabat)

<400>  144

Glu Val Arg Leu Arg Tyr Phe Asp Val 
1               5                   


<210>  145
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD33 antibody  VL CDR1 (Kabat & Chothia)

<400>  145

Lys Ser Ser Gln Ser Val Phe Phe Ser Ser Ser Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD33 antibody  VL CDR2 (Kabat & Chothia

<400>  146

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  147
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD33 antibody  VL CDR3 (Kabat & Chothia)

<400>  147

His Gln Tyr Leu Ser Ser Arg Thr 
1               5               


<210>  148
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD19 CAR  CD8[tm]-CD28[co-stimulatory 
       domain]-CD3z)

<400>  148
atgcttcttt tggttacgtc tctgttgctt tgcgaacttc ctcatccagc gttcttgctg       60

atccccgata ttcagatgac tcagaccacc agtagcttgt ctgcctcact gggagaccga      120

gtaacaatct cctgcagggc aagtcaagac attagcaaat acctcaattg gtaccagcag      180

aagcccgacg gaacggtaaa actcctcatc tatcatacgt caaggttgca ttccggagta      240

ccgtcacgat tttcaggttc tgggagcgga actgactatt ccttgactat ttcaaacctc      300

gagcaggagg acattgcgac atatttttgt caacaaggta ataccctccc ttacactttc      360

ggaggaggaa ccaaactcga aattaccggg tccaccagtg gctctgggaa gcctggcagt      420

ggagaaggtt ccactaaagg cgaggtgaag ctccaggaga gcggccccgg tctcgttgcc      480

cccagtcaaa gcctctctgt aacgtgcaca gtgagtggtg tatcattgcc tgattatggc      540

gtctcctgga taaggcagcc cccgcgaaag ggtcttgaat ggcttggggt aatatggggc      600

tcagagacaa cgtattataa ctccgctctc aaaagtcgct tgacgataat aaaagataac      660

tccaagagtc aagttttcct taaaatgaac agtttgcaga ctgacgatac cgctatatat      720

tattgtgcta aacattatta ctacggcggt agttacgcga tggattattg ggggcagggg      780

acttctgtca cagtcagtag tgctgctgcc tttgtcccgg tatttctccc agccaaaccg      840

accacgactc ccgccccgcg ccctccgaca cccgctccca ccatcgcctc tcaacctctt      900

agtcttcgcc ccgaggcatg ccgacccgcc gccgggggtg ctgttcatac gaggggcttg      960

gacttcgctt gtgatattta catttgggct ccgttggcgg gtacgtgcgg cgtccttttg     1020

ttgtcactcg ttattacttt gtattgtaat cacaggaatc gctcaaagcg gagtaggttg     1080

ttgcattccg attacatgaa tatgactcct cgccggcctg ggccgacaag aaaacattac     1140

caaccctatg cccccccacg agacttcgct gcgtacaggt cccgagtgaa gttttcccga     1200

agcgcagacg ctccggcata tcagcaagga cagaatcagc tgtataacga actgaatttg     1260

ggacgccgcg aggagtatga cgtgcttgat aaacgccggg ggagagaccc ggaaatgggg     1320

ggtaaacccc gaagaaagaa tccccaagaa ggactctaca atgaactcca gaaggataag     1380

atggcggagg cctactcaga aataggtatg aagggcgaac gacgacgggg aaaaggtcac     1440

gatggcctct accaagggtt gagtacggca accaaagata cgtacgatgc actgcatatg     1500

caggccctgc ctcccaga                                                   1518


<210>  149
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD19 CAR  CD8[tm]-CD28[co-stimulatory 
       domain]-CD3z) Amino Acid

<400>  149

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Phe Val 
            260                 265                 270         


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        275                 280                 285             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    290                 295                 300                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
305                 310                 315                 320 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                325                 330                 335     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
            340                 345                 350         


Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        355                 360                 365             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    370                 375                 380                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
385                 390                 395                 400 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                405                 410                 415     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            420                 425                 430         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        435                 440                 445             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    450                 455                 460                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
465                 470                 475                 480 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                485                 490                 495     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505     


<210>  150
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD19 scFv

<400>  150
gatattcaga tgactcagac caccagtagc ttgtctgcct cactgggaga ccgagtaaca       60

atctcctgca gggcaagtca agacattagc aaatacctca attggtacca gcagaagccc      120

gacggaacgg taaaactcct catctatcat acgtcaaggt tgcattccgg agtaccgtca      180

cgattttcag gttctgggag cggaactgac tattccttga ctatttcaaa cctcgagcag      240

gaggacattg cgacatattt ttgtcaacaa ggtaataccc tcccttacac tttcggagga      300

ggaaccaaac tcgaaattac cgggtccacc agtggctctg ggaagcctgg cagtggagaa      360

ggttccacta aaggcgaggt gaagctccag gagagcggcc ccggtctcgt tgcccccagt      420

caaagcctct ctgtaacgtg cacagtgagt ggtgtatcat tgcctgatta tggcgtctcc      480

tggataaggc agcccccgcg aaagggtctt gaatggcttg gggtaatatg gggctcagag      540

acaacgtatt ataactccgc tctcaaaagt cgcttgacga taataaaaga taactccaag      600

agtcaagttt tccttaaaat gaacagtttg cagactgacg ataccgctat atattattgt      660

gctaaacatt attactacgg cggtagttac gcgatggatt attgggggca ggggacttct      720

gtcacagtca gtagt                                                       735


<210>  151
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD19 scFv amino acid sequence Linker

<400>  151

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  152
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD19 VH

<400>  152

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  153
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD19 VL

<400>  153

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  154
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD19 scFv linker

<400>  154

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  155
<211>  4682
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD19 CAR rAAV

<400>  155
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgagatg taaggagctg ctgtgacttg ctcaaggcct      180

tatatcgagt aaacggtagt gctggggctt agacgcaggt gttctgattt atagttcaaa      240

acctctatca atgagagagc aatctcctgg taatgtgata gatttcccaa cttaatgcca      300

acataccata aacctcccat tctgctaatg cccagcctaa gttggggaga ccactccaga      360

ttccaagatg tacagtttgc tttgctgggc ctttttccca tgcctgcctt tactctgcca      420

gagttatatt gctggggttt tgaagaagat cctattaaat aaaagaataa gcagtattat      480

taagtagccc tgcatttcag gtttccttga gtggcaggcc aggcctggcc gtgaacgttc      540

actgaaatca tggcctcttg gccaagattg atagcttgtg cctgtccctg agtcccagtc      600

catcacgagc agctggtttc taagatgcta tttcccgtat aaagcatgag accgtgactt      660

gccagcccca cagagccccg cccttgtcca tcactggcat ctggactcca gcctgggttg      720

gggcaaagag ggaaatgaga tcatgtccta accctgatcc tcttgtccca cagatatcca      780

gaaccctgac cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg      840

cctattcacc gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta      900

tatcacagac aaaactgtgc tagacatgag gtctatggac ttcaggctcc ggtgcccgtc      960

agtgggcaga gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt     1020

gaaccggtgc ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc     1080

tccgcctttt tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg     1140

ttctttttcg caacgggttt gccgccagaa cacaggtaag tgccgtgtgt ggttcccgcg     1200

ggcctggcct ctttacgggt tatggccctt gcgtgccttg aattacttcc actggctgca     1260

gtacgtgatt cttgatcccg agcttcgggt tggaagtggg tgggagagtt cgaggccttg     1320

cgcttaagga gccccttcgc ctcgtgcttg agttgaggcc tggcctgggc gctggggccg     1380

ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct gctttcgata agtctctagc     1440

catttaaaat ttttgatgac ctgctgcgac gctttttttc tggcaagata gtcttgtaaa     1500

tgcgggccaa gatctgcaca ctggtatttc ggtttttggg gccgcgggcg gcgacggggc     1560

ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg cgagcgcggc caccgagaat     1620

cggacggggg tagtctcaag ctggccggcc tgctctggtg cctggcctcg cgccgccgtg     1680

tatcgccccg ccctgggcgg caaggctggc ccggtcggca ccagttgcgt gagcggaaag     1740

atggccgctt cccggccctg ctgcagggag ctcaaaatgg aggacgcggc gctcgggaga     1800

gcgggcgggt gagtcaccca cacaaaggaa aagggccttt ccgtcctcag ccgtcgcttc     1860

atgtgactcc acggagtacc gggcgccgtc caggcacctc gattagttct cgagcttttg     1920

gagtacgtcg tctttaggtt ggggggaggg gttttatgcg atggagtttc cccacactga     1980

gtgggtggag actgaagtta ggccagcttg gcacttgatg taattctcct tggaatttgc     2040

cctttttgag tttggatctt ggttcattct caagcctcag acagtggttc aaagtttttt     2100

tcttccattt caggtgtcgt gaccaccatg cttcttttgg ttacgtctct gttgctttgc     2160

gaacttcctc atccagcgtt cttgctgatc cccgatattc agatgactca gaccaccagt     2220

agcttgtctg cctcactggg agaccgagta acaatctcct gcagggcaag tcaagacatt     2280

agcaaatacc tcaattggta ccagcagaag cccgacggaa cggtaaaact cctcatctat     2340

catacgtcaa ggttgcattc cggagtaccg tcacgatttt caggttctgg gagcggaact     2400

gactattcct tgactatttc aaacctcgag caggaggaca ttgcgacata tttttgtcaa     2460

caaggtaata ccctccctta cactttcgga ggaggaacca aactcgaaat taccgggtcc     2520

accagtggct ctgggaagcc tggcagtgga gaaggttcca ctaaaggcga ggtgaagctc     2580

caggagagcg gccccggtct cgttgccccc agtcaaagcc tctctgtaac gtgcacagtg     2640

agtggtgtat cattgcctga ttatggcgtc tcctggataa ggcagccccc gcgaaagggt     2700

cttgaatggc ttggggtaat atggggctca gagacaacgt attataactc cgctctcaaa     2760

agtcgcttga cgataataaa agataactcc aagagtcaag ttttccttaa aatgaacagt     2820

ttgcagactg acgataccgc tatatattat tgtgctaaac attattacta cggcggtagt     2880

tacgcgatgg attattgggg gcaggggact tctgtcacag tcagtagtgc tgctgccttt     2940

gtcccggtat ttctcccagc caaaccgacc acgactcccg ccccgcgccc tccgacaccc     3000

gctcccacca tcgcctctca acctcttagt cttcgccccg aggcatgccg acccgccgcc     3060

gggggtgctg ttcatacgag gggcttggac ttcgcttgtg atatttacat ttgggctccg     3120

ttggcgggta cgtgcggcgt ccttttgttg tcactcgtta ttactttgta ttgtaatcac     3180

aggaatcgct caaagcggag taggttgttg cattccgatt acatgaatat gactcctcgc     3240

cggcctgggc cgacaagaaa acattaccaa ccctatgccc ccccacgaga cttcgctgcg     3300

tacaggtccc gagtgaagtt ttcccgaagc gcagacgctc cggcatatca gcaaggacag     3360

aatcagctgt ataacgaact gaatttggga cgccgcgagg agtatgacgt gcttgataaa     3420

cgccggggga gagacccgga aatggggggt aaaccccgaa gaaagaatcc ccaagaagga     3480

ctctacaatg aactccagaa ggataagatg gcggaggcct actcagaaat aggtatgaag     3540

ggcgaacgac gacggggaaa aggtcacgat ggcctctacc aagggttgag tacggcaacc     3600

aaagatacgt acgatgcact gcatatgcag gccctgcctc ccagataata ataaaatcgc     3660

tatccatcga agatggatgt gtgttggttt tttgtgtgtg gagcaacaaa tctgactttg     3720

catgtgcaaa cgccttcaac aacagcatta ttccagaaga caccttcttc cccagcccag     3780

gtaagggcag ctttggtgcc ttcgcaggct gtttccttgc ttcaggaatg gccaggttct     3840

gcccagagct ctggtcaatg atgtctaaaa ctcctctgat tggtggtctc ggccttatcc     3900

attgccacca aaaccctctt tttactaaga aacagtgagc cttgttctgg cagtccagag     3960

aatgacacgg gaaaaaagca gatgaagaga aggtggcagg agagggcacg tggcccagcc     4020

tcagtctctc caactgagtt cctgcctgcc tgcctttgct cagactgttt gccccttact     4080

gctcttctag gcctcattct aagccccttc tccaagttgc ctctccttat ttctccctgt     4140

ctgccaaaaa atctttccca gctcactaag tcagtctcac gcagtcactc attaacccac     4200

caatcactga ttgtgccggc acatgaatgc accaggtgtt gaagtggagg aattaaaaag     4260

tcagatgagg ggtgtgccca gaggaagcac cattctagtt gggggagccc atctgtcagc     4320

tgggaaaagt ccaaataact tcagattgga atgtgtttta actcagggtt gagaaaacag     4380

ctaccttcag gacaaaagtc agggaagggc tctctgaaga aatgctactt gaagatacca     4440

gccctaccaa gggcagggag aggaccctat agaggcctgg gacaggagct caatgagaaa     4500

ggtaaccacg tgcggaccga ggctgcagcg tcgtcctccc taggaacccc tagtgatgga     4560

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4620

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcctgca     4680

gg                                                                    4682


<210>  156
<211>  4358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD19 CAR LHA to RHA

<400>  156
gagatgtaag gagctgctgt gacttgctca aggccttata tcgagtaaac ggtagtgctg       60

gggcttagac gcaggtgttc tgatttatag ttcaaaacct ctatcaatga gagagcaatc      120

tcctggtaat gtgatagatt tcccaactta atgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg ccgtgtacca      660

gctgagagac tctaaatcca gtgacaagtc tgtctgccta ttcaccgatt ttgattctca      720

aacaaatgtg tcacaaagta aggattctga tgtgtatatc acagacaaaa ctgtgctaga      780

catgaggtct atggacttca ggctccggtg cccgtcagtg ggcagagcgc acatcgccca      840

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc      900

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg      960

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     1020

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     1080

gcccttgcgt gccttgaatt acttccactg gctgcagtac gtgattcttg atcccgagct     1140

tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc cttcgcctcg     1200

tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct     1260

tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacctgc     1320

tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc tgcacactgg     1380

tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc gcacatgttc     1440

ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg     1500

ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag     1560

gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc     1620

agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca     1680

aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc     1740

gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt taggttgggg     1800

ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc     1860

agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg gatcttggtt     1920

cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg tgtcgtgacc     1980

accatgcttc ttttggttac gtctctgttg ctttgcgaac ttcctcatcc agcgttcttg     2040

ctgatccccg atattcagat gactcagacc accagtagct tgtctgcctc actgggagac     2100

cgagtaacaa tctcctgcag ggcaagtcaa gacattagca aatacctcaa ttggtaccag     2160

cagaagcccg acggaacggt aaaactcctc atctatcata cgtcaaggtt gcattccgga     2220

gtaccgtcac gattttcagg ttctgggagc ggaactgact attccttgac tatttcaaac     2280

ctcgagcagg aggacattgc gacatatttt tgtcaacaag gtaataccct cccttacact     2340

ttcggaggag gaaccaaact cgaaattacc gggtccacca gtggctctgg gaagcctggc     2400

agtggagaag gttccactaa aggcgaggtg aagctccagg agagcggccc cggtctcgtt     2460

gcccccagtc aaagcctctc tgtaacgtgc acagtgagtg gtgtatcatt gcctgattat     2520

ggcgtctcct ggataaggca gcccccgcga aagggtcttg aatggcttgg ggtaatatgg     2580

ggctcagaga caacgtatta taactccgct ctcaaaagtc gcttgacgat aataaaagat     2640

aactccaaga gtcaagtttt ccttaaaatg aacagtttgc agactgacga taccgctata     2700

tattattgtg ctaaacatta ttactacggc ggtagttacg cgatggatta ttgggggcag     2760

gggacttctg tcacagtcag tagtgctgct gcctttgtcc cggtatttct cccagccaaa     2820

ccgaccacga ctcccgcccc gcgccctccg acacccgctc ccaccatcgc ctctcaacct     2880

cttagtcttc gccccgaggc atgccgaccc gccgccgggg gtgctgttca tacgaggggc     2940

ttggacttcg cttgtgatat ttacatttgg gctccgttgg cgggtacgtg cggcgtcctt     3000

ttgttgtcac tcgttattac tttgtattgt aatcacagga atcgctcaaa gcggagtagg     3060

ttgttgcatt ccgattacat gaatatgact cctcgccggc ctgggccgac aagaaaacat     3120

taccaaccct atgccccccc acgagacttc gctgcgtaca ggtcccgagt gaagttttcc     3180

cgaagcgcag acgctccggc atatcagcaa ggacagaatc agctgtataa cgaactgaat     3240

ttgggacgcc gcgaggagta tgacgtgctt gataaacgcc gggggagaga cccggaaatg     3300

gggggtaaac cccgaagaaa gaatccccaa gaaggactct acaatgaact ccagaaggat     3360

aagatggcgg aggcctactc agaaataggt atgaagggcg aacgacgacg gggaaaaggt     3420

cacgatggcc tctaccaagg gttgagtacg gcaaccaaag atacgtacga tgcactgcat     3480

atgcaggccc tgcctcccag ataataataa aatcgctatc catcgaagat ggatgtgtgt     3540

tggttttttg tgtgtggagc aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca     3600

gcattattcc agaagacacc ttcttcccca gcccaggtaa gggcagcttt ggtgccttcg     3660

caggctgttt ccttgcttca ggaatggcca ggttctgccc agagctctgg tcaatgatgt     3720

ctaaaactcc tctgattggt ggtctcggcc ttatccattg ccaccaaaac cctcttttta     3780

ctaagaaaca gtgagccttg ttctggcagt ccagagaatg acacgggaaa aaagcagatg     3840

aagagaaggt ggcaggagag ggcacgtggc ccagcctcag tctctccaac tgagttcctg     3900

cctgcctgcc tttgctcaga ctgtttgccc cttactgctc ttctaggcct cattctaagc     3960

cccttctcca agttgcctct ccttatttct ccctgtctgc caaaaaatct ttcccagctc     4020

actaagtcag tctcacgcag tcactcatta acccaccaat cactgattgt gccggcacat     4080

gaatgcacca ggtgttgaag tggaggaatt aaaaagtcag atgaggggtg tgcccagagg     4140

aagcaccatt ctagttgggg gagcccatct gtcagctggg aaaagtccaa ataacttcag     4200

attggaatgt gttttaactc agggttgaga aaacagctac cttcaggaca aaagtcaggg     4260

aagggctctc tgaagaaatg ctacttgaag ataccagccc taccaagggc agggagagga     4320

ccctatagag gcctgggaca ggagctcaat gagaaagg                             4358


<210>  157
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T1)

<400>  157
tcaccaagcc cgcgaccaat                                                   20


<210>  158
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T3)

<400>  158
atcaccaagc ccgcgaccaa                                                   20


<210>  159
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T4)

<400>  159
cggtgcggcg caggccctat                                                   20


<210>  160
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T7)

<400>  160
gctttggtcc cattggtcgc                                                   20


<210>  161
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T8)

<400>  161
gcccgcagga cgcacccata                                                   20


<210>  162
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E1_T10)

<400>  162
gtgcatccag cgcttcgcac                                                   20


<210>  163
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD70 sgRNA (E3_T1)

<400>  163
cagctacgta tccatcgtga                                                   20


<210>  164
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: b2M sgRNA

<400>  164
gctactctct ctttctggcc                                                   20


<210>  165
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: PD-1 sgRNA

<400>  165
ctgcagcttc tccaacacat                                                   20


<210>  166
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD19 VL CDR1 (Kabat)

<400>  166

Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
1               5                   10      


<210>  167
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD19 VL CDR2 (Kabat)

<400>  167

His Thr Ser Arg Leu His Ser 
1               5           


<210>  168
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD19 VL CDR3 (Kabat)

<400>  168

Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
1               5                   


<210>  169
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD19 VH CDR1 (Kabat)

<400>  169

Asp Tyr Gly Val Ser 
1               5   


<210>  170
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD19 VH CDR2 (Kabat)

<400>  170

Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  171
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD19 VH CDR3 (Kabat)

<400>  171

His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  172
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD19 VL CDR1 (Chothia)

<400>  172

Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
1               5                   10      


<210>  173
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD19 VL CDR2 (Chothia)

<400>  173

His Thr Ser Arg Leu His Ser 
1               5           


<210>  174
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD19 VL CDR3 (Chothia)

<400>  174

Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
1               5                   


<210>  175
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD19 VH CDR1 (Chothia)

<400>  175

Gly Val Ser Leu Pro Asp Tyr 
1               5           


<210>  176
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD19 VH CDR2 (Chothia)

<400>  176

Trp Gly Ser Glu Thr 
1               5   


<210>  177
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD19 VH CDR3 (Chothia)

<400>  177

His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  178
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD33 VH CDR1 (Chothia)

<400>  178

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  179
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD33 VH CDR2 (Chothia)

<400>  179

Tyr Pro Gly Asn Asp Asp 
1               5       


<210>  180
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: anti-CD33 VH CDR3 (Chothia)

<400>  180

Glu Val Arg Leu Arg Tyr Phe Asp Val 
1               5                   


