                         SEQUENCE LISTING

<110>  CSL Limited
       CSL Behring AG
 
<120>  SOLUBLE COMPLEMENT RECEPTOR TYPE 1 VARIANTS AND USES THEREOF

<130>  524790PCT

<150>  2018901703
<151>  2018-05-16

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  1971
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1

<400>  1

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Thr 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Thr Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Thr  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Thr Asp 
    1460                 1465                 1470             


Thr Gln  Phe Gly Ser Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Thr Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Thr Ser Phe His Asn  Gly Thr Val Val Thr  Tyr Gln Cys 
    1535                 1540                 1545             


His Thr  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Ser  Leu Thr Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Thr  Val Gln Cys Gln Thr  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Thr Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Thr  His Pro Asp Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Thr Ile Ser Tyr  Ile Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Thr Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg 
    1955                 1960                 1965             


Thr His  Asp 
    1970     


<210>  2
<211>  1930
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(1971)

<400>  2

Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn Leu 
1               5                   10                  15      


Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu Cys 
            20                  25                  30          


Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys Asn 
        35                  40                  45              


Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys Arg 
    50                  55                  60                  


Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg Leu 
                85                  90                  95      


Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val Ile 
            100                 105                 110         


Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu Pro 
        115                 120                 125             


Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe 
    130                 135                 140                 


His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly 
145                 150                 155                 160 


Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser 
                165                 170                 175     


Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile 
            180                 185                 190         


Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val 
        195                 200                 205             


Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg 
    210                 215                 220                 


Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln 
225                 230                 235                 240 


Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys 
                245                 250                 255     


Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys 
            260                 265                 270         


Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly 
        275                 280                 285             


Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp 
    290                 295                 300                 


Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe 
305                 310                 315                 320 


Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln 
                325                 330                 335     


Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys 
            340                 345                 350         


Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp 
        355                 360                 365             


Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro 
    370                 375                 380                 


Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro 
385                 390                 395                 400 


Phe Gly Lys Thr Val Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly 
                405                 410                 415     


Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp 
            420                 425                 430         


Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile 
        435                 440                 445             


Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys 
    450                 455                 460                 


Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr 
465                 470                 475                 480 


Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu 
                485                 490                 495     


Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser 
            500                 505                 510         


Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr 
        515                 520                 525             


Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His 
    530                 535                 540                 


Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala 
545                 550                 555                 560 


Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly 
                565                 570                 575     


Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu 
            580                 585                 590         


Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser 
        595                 600                 605             


Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys 
    610                 615                 620                 


Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln 
625                 630                 635                 640 


Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile 
                645                 650                 655     


Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu 
            660                 665                 670         


Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys 
        675                 680                 685             


Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg 
    690                 695                 700                 


Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg 
705                 710                 715                 720 


Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
                725                 730                 735     


Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln 
            740                 745                 750         


Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp 
        755                 760                 765             


Asp Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn 
    770                 775                 780                 


Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln 
785                 790                 795                 800 


Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser 
                805                 810                 815     


Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser 
            820                 825                 830         


Pro Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val 
        835                 840                 845             


Phe Pro Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro His Pro Asp 
    850                 855                 860                 


Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr 
865                 870                 875                 880 


Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
                885                 890                 895     


Gly Ile Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys 
            900                 905                 910         


Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu 
        915                 920                 925             


Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr 
    930                 935                 940                 


Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg 
945                 950                 955                 960 


Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val 
                965                 970                 975     


Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr 
            980                 985                 990         


Gly His Arg Leu Ile Gly His Ser  Ser Ala Glu Cys Ile  Leu Ser Gly 
        995                 1000                 1005             


Asn Thr  Ala His Trp Ser Thr  Lys Pro Pro Ile Cys  Gln Arg Ile 
    1010                 1015                 1020             


Pro Cys  Gly Leu Pro Pro Thr  Ile Ala Asn Gly Asp  Phe Ile Ser 
    1025                 1030                 1035             


Thr Asn  Arg Glu Asn Phe His  Tyr Gly Ser Val Val  Thr Tyr Arg 
    1040                 1045                 1050             


Cys Asn  Leu Gly Ser Arg Gly  Arg Lys Val Phe Glu  Leu Val Gly 
    1055                 1060                 1065             


Glu Pro  Ser Ile Tyr Cys Thr  Ser Asn Asp Asp Gln  Val Gly Ile 
    1070                 1075                 1080             


Trp Ser  Gly Pro Ala Pro Gln  Cys Ile Ile Pro Asn  Lys Cys Thr 
    1085                 1090                 1095             


Pro Pro  Asn Val Glu Asn Gly  Ile Leu Val Ser Asp  Asn Arg Ser 
    1100                 1105                 1110             


Leu Phe  Ser Leu Asn Glu Val  Val Glu Phe Arg Cys  Gln Pro Gly 
    1115                 1120                 1125             


Phe Val  Met Lys Gly Pro Arg  Arg Val Lys Cys Gln  Ala Leu Asn 
    1130                 1135                 1140             


Lys Trp  Glu Pro Glu Leu Pro  Ser Cys Ser Arg Val  Cys Gln Pro 
    1145                 1150                 1155             


Pro Pro  Glu Ile Leu His Gly  Glu His Thr Pro Ser  His Gln Asp 
    1160                 1165                 1170             


Asn Phe  Ser Pro Gly Gln Glu  Val Phe Tyr Ser Cys  Glu Pro Gly 
    1175                 1180                 1185             


Tyr Asp  Leu Arg Gly Ala Ala  Ser Leu His Cys Thr  Pro Gln Gly 
    1190                 1195                 1200             


Asp Trp  Ser Pro Glu Ala Pro  Arg Cys Ala Val Lys  Ser Cys Asp 
    1205                 1210                 1215             


Asp Phe  Leu Gly Gln Leu Pro  His Gly Arg Val Leu  Phe Pro Leu 
    1220                 1225                 1230             


Asn Leu  Gln Leu Gly Ala Lys  Val Ser Phe Val Cys  Asp Glu Gly 
    1235                 1240                 1245             


Phe Arg  Leu Lys Gly Ser Ser  Val Ser His Cys Val  Leu Val Gly 
    1250                 1255                 1260             


Met Arg  Ser Leu Trp Asn Asn  Ser Val Pro Val Cys  Glu His Ile 
    1265                 1270                 1275             


Phe Cys  Pro Asn Pro Pro Ala  Ile Leu Asn Gly Arg  His Thr Gly 
    1280                 1285                 1290             


Thr Pro  Ser Gly Asp Ile Pro  Tyr Gly Lys Glu Ile  Ser Tyr Thr 
    1295                 1300                 1305             


Cys Asp  Pro His Pro Asp Arg  Gly Met Thr Phe Asn  Leu Ile Gly 
    1310                 1315                 1320             


Glu Ser  Thr Ile Arg Cys Thr  Ser Asp Pro His Gly  Asn Gly Val 
    1325                 1330                 1335             


Trp Ser  Ser Pro Ala Pro Arg  Cys Glu Leu Ser Val  Arg Ala Gly 
    1340                 1345                 1350             


His Cys  Lys Thr Pro Glu Gln  Phe Pro Phe Ala Ser  Pro Thr Ile 
    1355                 1360                 1365             


Pro Ile  Asn Asp Phe Glu Phe  Pro Val Gly Thr Ser  Leu Asn Tyr 
    1370                 1375                 1380             


Glu Cys  Arg Pro Gly Tyr Phe  Gly Lys Met Phe Ser  Ile Ser Cys 
    1385                 1390                 1395             


Leu Glu  Asn Leu Val Trp Ser  Ser Val Glu Asp Asn  Cys Arg Arg 
    1400                 1405                 1410             


Lys Ser  Cys Gly Pro Pro Pro  Glu Pro Phe Asn Gly  Met Val His 
    1415                 1420                 1425             


Ile Asn  Thr Asp Thr Gln Phe  Gly Ser Thr Val Asn  Tyr Ser Cys 
    1430                 1435                 1440             


Asn Glu  Gly Phe Arg Leu Ile  Gly Ser Pro Ser Thr  Thr Cys Leu 
    1445                 1450                 1455             


Val Ser  Gly Asn Asn Val Thr  Trp Asp Lys Lys Ala  Pro Ile Cys 
    1460                 1465                 1470             


Glu Ile  Ile Ser Cys Glu Pro  Pro Pro Thr Ile Ser  Asn Gly Asp 
    1475                 1480                 1485             


Phe Tyr  Ser Asn Asn Arg Thr  Ser Phe His Asn Gly  Thr Val Val 
    1490                 1495                 1500             


Thr Tyr  Gln Cys His Thr Gly  Pro Asp Gly Glu Gln  Leu Phe Glu 
    1505                 1510                 1515             


Leu Val  Gly Glu Arg Ser Ile  Tyr Cys Thr Ser Lys  Asp Asp Gln 
    1520                 1525                 1530             


Val Gly  Val Trp Ser Ser Pro  Pro Pro Arg Cys Ile  Ser Thr Asn 
    1535                 1540                 1545             


Lys Cys  Thr Ala Pro Glu Val  Glu Asn Ala Ile Arg  Val Pro Gly 
    1550                 1555                 1560             


Asn Arg  Ser Phe Phe Ser Leu  Thr Glu Ile Ile Arg  Phe Arg Cys 
    1565                 1570                 1575             


Gln Pro  Gly Phe Val Met Val  Gly Ser His Thr Val  Gln Cys Gln 
    1580                 1585                 1590             


Thr Asn  Gly Arg Trp Gly Pro  Lys Leu Pro His Cys  Ser Arg Val 
    1595                 1600                 1605             


Cys Gln  Pro Pro Pro Glu Ile  Leu His Gly Glu His  Thr Leu Ser 
    1610                 1615                 1620             


His Gln  Asp Asn Phe Ser Pro  Gly Gln Glu Val Phe  Tyr Ser Cys 
    1625                 1630                 1635             


Glu Pro  Ser Tyr Asp Leu Arg  Gly Ala Ala Ser Leu  His Cys Thr 
    1640                 1645                 1650             


Pro Gln  Gly Asp Trp Ser Pro  Glu Ala Pro Arg Cys  Thr Val Lys 
    1655                 1660                 1665             


Ser Cys  Asp Asp Phe Leu Gly  Gln Leu Pro His Gly  Arg Val Leu 
    1670                 1675                 1680             


Leu Pro  Leu Asn Leu Gln Leu  Gly Ala Lys Val Ser  Phe Val Cys 
    1685                 1690                 1695             


Asp Glu  Gly Phe Arg Leu Lys  Gly Arg Ser Ala Ser  His Cys Val 
    1700                 1705                 1710             


Leu Ala  Gly Met Lys Ala Leu  Trp Asn Ser Ser Val  Pro Val Cys 
    1715                 1720                 1725             


Glu Gln  Ile Phe Cys Pro Asn  Pro Pro Ala Ile Leu  Asn Gly Arg 
    1730                 1735                 1740             


His Thr  Gly Thr Pro Phe Gly  Asp Ile Pro Tyr Gly  Lys Glu Ile 
    1745                 1750                 1755             


Ser Tyr  Ala Cys Asp Thr His  Pro Asp Arg Gly Met  Thr Phe Asn 
    1760                 1765                 1770             


Leu Ile  Gly Glu Ser Ser Ile  Arg Cys Thr Ser Asp  Pro Gln Gly 
    1775                 1780                 1785             


Asn Gly  Val Trp Ser Ser Pro  Ala Pro Arg Cys Glu  Leu Ser Val 
    1790                 1795                 1800             


Pro Ala  Ala Cys Pro His Pro  Pro Lys Ile Gln Asn  Gly His Tyr 
    1805                 1810                 1815             


Ile Gly  Gly His Val Ser Leu  Tyr Leu Pro Gly Met  Thr Ile Ser 
    1820                 1825                 1830             


Tyr Ile  Cys Asp Pro Gly Tyr  Leu Leu Val Gly Lys  Gly Phe Ile 
    1835                 1840                 1845             


Phe Cys  Thr Asp Gln Gly Ile  Trp Ser Gln Leu Asp  His Tyr Cys 
    1850                 1855                 1860             


Lys Glu  Val Asn Cys Ser Phe  Pro Leu Phe Met Asn  Gly Ile Ser 
    1865                 1870                 1875             


Lys Glu  Leu Glu Met Lys Lys  Val Tyr His Tyr Gly  Asp Tyr Val 
    1880                 1885                 1890             


Thr Leu  Lys Cys Glu Asp Gly  Tyr Thr Leu Glu Gly  Ser Pro Trp 
    1895                 1900                 1905             


Ser Gln  Cys Gln Ala Asp Asp  Arg Trp Asp Pro Pro  Leu Ala Lys 
    1910                 1915                 1920             


Cys Thr  Ser Arg Thr His Asp  
    1925                 1930 


<210>  3
<211>  1351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(1392)

<400>  3

Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn Leu 
1               5                   10                  15      


Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu Cys 
            20                  25                  30          


Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys Asn 
        35                  40                  45              


Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys Arg 
    50                  55                  60                  


Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg Leu 
                85                  90                  95      


Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val Ile 
            100                 105                 110         


Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu Pro 
        115                 120                 125             


Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe 
    130                 135                 140                 


His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly 
145                 150                 155                 160 


Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser 
                165                 170                 175     


Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile 
            180                 185                 190         


Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val 
        195                 200                 205             


Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg 
    210                 215                 220                 


Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln 
225                 230                 235                 240 


Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys 
                245                 250                 255     


Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys 
            260                 265                 270         


Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly 
        275                 280                 285             


Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp 
    290                 295                 300                 


Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe 
305                 310                 315                 320 


Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln 
                325                 330                 335     


Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys 
            340                 345                 350         


Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp 
        355                 360                 365             


Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro 
    370                 375                 380                 


Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro 
385                 390                 395                 400 


Phe Gly Lys Thr Val Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly 
                405                 410                 415     


Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp 
            420                 425                 430         


Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile 
        435                 440                 445             


Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys 
    450                 455                 460                 


Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr 
465                 470                 475                 480 


Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu 
                485                 490                 495     


Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser 
            500                 505                 510         


Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr 
        515                 520                 525             


Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His 
    530                 535                 540                 


Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala 
545                 550                 555                 560 


Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly 
                565                 570                 575     


Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu 
            580                 585                 590         


Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser 
        595                 600                 605             


Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys 
    610                 615                 620                 


Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln 
625                 630                 635                 640 


Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile 
                645                 650                 655     


Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu 
            660                 665                 670         


Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys 
        675                 680                 685             


Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg 
    690                 695                 700                 


Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg 
705                 710                 715                 720 


Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
                725                 730                 735     


Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln 
            740                 745                 750         


Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp 
        755                 760                 765             


Asp Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn 
    770                 775                 780                 


Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln 
785                 790                 795                 800 


Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser 
                805                 810                 815     


Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser 
            820                 825                 830         


Pro Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val 
        835                 840                 845             


Phe Pro Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro His Pro Asp 
    850                 855                 860                 


Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr 
865                 870                 875                 880 


Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
                885                 890                 895     


Gly Ile Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys 
            900                 905                 910         


Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu 
        915                 920                 925             


Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr 
    930                 935                 940                 


Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg 
945                 950                 955                 960 


Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val 
                965                 970                 975     


Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr 
            980                 985                 990         


Gly His Arg Leu Ile Gly His Ser  Ser Ala Glu Cys Ile  Leu Ser Gly 
        995                 1000                 1005             


Asn Thr  Ala His Trp Ser Thr  Lys Pro Pro Ile Cys  Gln Arg Ile 
    1010                 1015                 1020             


Pro Cys  Gly Leu Pro Pro Thr  Ile Ala Asn Gly Asp  Phe Ile Ser 
    1025                 1030                 1035             


Thr Asn  Arg Glu Asn Phe His  Tyr Gly Ser Val Val  Thr Tyr Arg 
    1040                 1045                 1050             


Cys Asn  Leu Gly Ser Arg Gly  Arg Lys Val Phe Glu  Leu Val Gly 
    1055                 1060                 1065             


Glu Pro  Ser Ile Tyr Cys Thr  Ser Asn Asp Asp Gln  Val Gly Ile 
    1070                 1075                 1080             


Trp Ser  Gly Pro Ala Pro Gln  Cys Ile Ile Pro Asn  Lys Cys Thr 
    1085                 1090                 1095             


Pro Pro  Asn Val Glu Asn Gly  Ile Leu Val Ser Asp  Asn Arg Ser 
    1100                 1105                 1110             


Leu Phe  Ser Leu Asn Glu Val  Val Glu Phe Arg Cys  Gln Pro Gly 
    1115                 1120                 1125             


Phe Val  Met Lys Gly Pro Arg  Arg Val Lys Cys Gln  Ala Leu Asn 
    1130                 1135                 1140             


Lys Trp  Glu Pro Glu Leu Pro  Ser Cys Ser Arg Val  Cys Gln Pro 
    1145                 1150                 1155             


Pro Pro  Glu Ile Leu His Gly  Glu His Thr Pro Ser  His Gln Asp 
    1160                 1165                 1170             


Asn Phe  Ser Pro Gly Gln Glu  Val Phe Tyr Ser Cys  Glu Pro Gly 
    1175                 1180                 1185             


Tyr Asp  Leu Arg Gly Ala Ala  Ser Leu His Cys Thr  Pro Gln Gly 
    1190                 1195                 1200             


Asp Trp  Ser Pro Glu Ala Pro  Arg Cys Ala Val Lys  Ser Cys Asp 
    1205                 1210                 1215             


Asp Phe  Leu Gly Gln Leu Pro  His Gly Arg Val Leu  Phe Pro Leu 
    1220                 1225                 1230             


Asn Leu  Gln Leu Gly Ala Lys  Val Ser Phe Val Cys  Asp Glu Gly 
    1235                 1240                 1245             


Phe Arg  Leu Lys Gly Ser Ser  Val Ser His Cys Val  Leu Val Gly 
    1250                 1255                 1260             


Met Arg  Ser Leu Trp Asn Asn  Ser Val Pro Val Cys  Glu His Ile 
    1265                 1270                 1275             


Phe Cys  Pro Asn Pro Pro Ala  Ile Leu Asn Gly Arg  His Thr Gly 
    1280                 1285                 1290             


Thr Pro  Ser Gly Asp Ile Pro  Tyr Gly Lys Glu Ile  Ser Tyr Thr 
    1295                 1300                 1305             


Cys Asp  Pro His Pro Asp Arg  Gly Met Thr Phe Asn  Leu Ile Gly 
    1310                 1315                 1320             


Glu Ser  Thr Ile Arg Cys Thr  Ser Asp Pro His Gly  Asn Gly Val 
    1325                 1330                 1335             


Trp Ser  Ser Pro Ala Pro Arg  Cys Glu Leu Ser Val  Arg 
    1340                 1345                 1350     


<210>  4
<211>  898
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(939)

<400>  4

Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn Leu 
1               5                   10                  15      


Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu Cys 
            20                  25                  30          


Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys Asn 
        35                  40                  45              


Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys Arg 
    50                  55                  60                  


Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg Leu 
                85                  90                  95      


Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val Ile 
            100                 105                 110         


Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu Pro 
        115                 120                 125             


Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe 
    130                 135                 140                 


His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly 
145                 150                 155                 160 


Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser 
                165                 170                 175     


Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile 
            180                 185                 190         


Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val 
        195                 200                 205             


Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg 
    210                 215                 220                 


Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln 
225                 230                 235                 240 


Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys 
                245                 250                 255     


Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys 
            260                 265                 270         


Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly 
        275                 280                 285             


Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp 
    290                 295                 300                 


Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe 
305                 310                 315                 320 


Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln 
                325                 330                 335     


Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys 
            340                 345                 350         


Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp 
        355                 360                 365             


Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro 
    370                 375                 380                 


Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro 
385                 390                 395                 400 


Phe Gly Lys Thr Val Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly 
                405                 410                 415     


Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp 
            420                 425                 430         


Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile 
        435                 440                 445             


Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys 
    450                 455                 460                 


Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr 
465                 470                 475                 480 


Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu 
                485                 490                 495     


Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser 
            500                 505                 510         


Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr 
        515                 520                 525             


Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His 
    530                 535                 540                 


Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala 
545                 550                 555                 560 


Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly 
                565                 570                 575     


Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu 
            580                 585                 590         


Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser 
        595                 600                 605             


Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys 
    610                 615                 620                 


Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln 
625                 630                 635                 640 


Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile 
                645                 650                 655     


Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu 
            660                 665                 670         


Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys 
        675                 680                 685             


Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg 
    690                 695                 700                 


Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg 
705                 710                 715                 720 


Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
                725                 730                 735     


Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln 
            740                 745                 750         


Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp 
        755                 760                 765             


Asp Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn 
    770                 775                 780                 


Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln 
785                 790                 795                 800 


Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser 
                805                 810                 815     


Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser 
            820                 825                 830         


Pro Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val 
        835                 840                 845             


Phe Pro Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro His Pro Asp 
    850                 855                 860                 


Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr 
865                 870                 875                 880 


Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
                885                 890                 895     


Gly Ile 
        


<210>  5
<211>  903
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(490-1392)

<400>  5

Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys 
1               5                   10                  15      


Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr 
            20                  25                  30          


Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu 
        35                  40                  45              


Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser 
    50                  55                  60                  


Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr 
65                  70                  75                  80  


Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His 
                85                  90                  95      


Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala 
            100                 105                 110         


Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly 
        115                 120                 125             


Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu 
    130                 135                 140                 


Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser 
145                 150                 155                 160 


Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys 
                165                 170                 175     


Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln 
            180                 185                 190         


Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile 
        195                 200                 205             


Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu 
    210                 215                 220                 


Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys 
225                 230                 235                 240 


Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg 
                245                 250                 255     


Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg 
            260                 265                 270         


Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
        275                 280                 285             


Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln 
    290                 295                 300                 


Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp 
305                 310                 315                 320 


Asp Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn 
                325                 330                 335     


Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln 
            340                 345                 350         


Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser 
        355                 360                 365             


Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser 
    370                 375                 380                 


Pro Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val 
385                 390                 395                 400 


Phe Pro Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro His Pro Asp 
                405                 410                 415     


Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr 
            420                 425                 430         


Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
        435                 440                 445             


Gly Ile Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys 
    450                 455                 460                 


Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu 
465                 470                 475                 480 


Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr 
                485                 490                 495     


Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg 
            500                 505                 510         


Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val 
        515                 520                 525             


Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr 
    530                 535                 540                 


Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly 
545                 550                 555                 560 


Asn Thr Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro 
                565                 570                 575     


Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn 
            580                 585                 590         


Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu 
        595                 600                 605             


Gly Ser Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile 
    610                 615                 620                 


Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala 
625                 630                 635                 640 


Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn 
                645                 650                 655     


Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val 
            660                 665                 670         


Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg 
        675                 680                 685             


Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys 
    690                 695                 700                 


Ser Arg Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His Thr 
705                 710                 715                 720 


Pro Ser His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser 
                725                 730                 735     


Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr 
            740                 745                 750         


Pro Gln Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Ala Val Lys Ser 
        755                 760                 765             


Cys Asp Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Phe Pro 
    770                 775                 780                 


Leu Asn Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly 
785                 790                 795                 800 


Phe Arg Leu Lys Gly Ser Ser Val Ser His Cys Val Leu Val Gly Met 
                805                 810                 815     


Arg Ser Leu Trp Asn Asn Ser Val Pro Val Cys Glu His Ile Phe Cys 
            820                 825                 830         


Pro Asn Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Ser 
        835                 840                 845             


Gly Asp Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Thr Cys Asp Pro His 
    850                 855                 860                 


Pro Asp Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Thr Ile Arg 
865                 870                 875                 880 


Cys Thr Ser Asp Pro His Gly Asn Gly Val Trp Ser Ser Pro Ala Pro 
                885                 890                 895     


Arg Cys Glu Leu Ser Val Arg 
            900             


<210>  6
<211>  1482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(490-1971)

<400>  6

Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys 
1               5                   10                  15      


Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr 
            20                  25                  30          


Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu 
        35                  40                  45              


Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser 
    50                  55                  60                  


Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr 
65                  70                  75                  80  


Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His 
                85                  90                  95      


Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala 
            100                 105                 110         


Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly 
        115                 120                 125             


Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu 
    130                 135                 140                 


Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser 
145                 150                 155                 160 


Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys 
                165                 170                 175     


Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln 
            180                 185                 190         


Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile 
        195                 200                 205             


Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu 
    210                 215                 220                 


Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys 
225                 230                 235                 240 


Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg 
                245                 250                 255     


Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg 
            260                 265                 270         


Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
        275                 280                 285             


Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln 
    290                 295                 300                 


Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp 
305                 310                 315                 320 


Asp Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn 
                325                 330                 335     


Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln 
            340                 345                 350         


Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser 
        355                 360                 365             


Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser 
    370                 375                 380                 


Pro Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val 
385                 390                 395                 400 


Phe Pro Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro His Pro Asp 
                405                 410                 415     


Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr 
            420                 425                 430         


Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
        435                 440                 445             


Gly Ile Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys 
    450                 455                 460                 


Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu 
465                 470                 475                 480 


Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr 
                485                 490                 495     


Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg 
            500                 505                 510         


Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val 
        515                 520                 525             


Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr 
    530                 535                 540                 


Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly 
545                 550                 555                 560 


Asn Thr Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro 
                565                 570                 575     


Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn 
            580                 585                 590         


Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu 
        595                 600                 605             


Gly Ser Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile 
    610                 615                 620                 


Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala 
625                 630                 635                 640 


Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn 
                645                 650                 655     


Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val 
            660                 665                 670         


Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg 
        675                 680                 685             


Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys 
    690                 695                 700                 


Ser Arg Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His Thr 
705                 710                 715                 720 


Pro Ser His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser 
                725                 730                 735     


Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr 
            740                 745                 750         


Pro Gln Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Ala Val Lys Ser 
        755                 760                 765             


Cys Asp Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Phe Pro 
    770                 775                 780                 


Leu Asn Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly 
785                 790                 795                 800 


Phe Arg Leu Lys Gly Ser Ser Val Ser His Cys Val Leu Val Gly Met 
                805                 810                 815     


Arg Ser Leu Trp Asn Asn Ser Val Pro Val Cys Glu His Ile Phe Cys 
            820                 825                 830         


Pro Asn Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Ser 
        835                 840                 845             


Gly Asp Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Thr Cys Asp Pro His 
    850                 855                 860                 


Pro Asp Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Thr Ile Arg 
865                 870                 875                 880 


Cys Thr Ser Asp Pro His Gly Asn Gly Val Trp Ser Ser Pro Ala Pro 
                885                 890                 895     


Arg Cys Glu Leu Ser Val Arg Ala Gly His Cys Lys Thr Pro Glu Gln 
            900                 905                 910         


Phe Pro Phe Ala Ser Pro Thr Ile Pro Ile Asn Asp Phe Glu Phe Pro 
        915                 920                 925             


Val Gly Thr Ser Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Phe Gly Lys 
    930                 935                 940                 


Met Phe Ser Ile Ser Cys Leu Glu Asn Leu Val Trp Ser Ser Val Glu 
945                 950                 955                 960 


Asp Asn Cys Arg Arg Lys Ser Cys Gly Pro Pro Pro Glu Pro Phe Asn 
                965                 970                 975     


Gly Met Val His Ile Asn Thr Asp Thr Gln Phe Gly Ser Thr Val Asn 
            980                 985                 990         


Tyr Ser Cys Asn Glu Gly Phe Arg  Leu Ile Gly Ser Pro  Ser Thr Thr 
        995                 1000                 1005             


Cys Leu  Val Ser Gly Asn Asn  Val Thr Trp Asp Lys  Lys Ala Pro 
    1010                 1015                 1020             


Ile Cys  Glu Ile Ile Ser Cys  Glu Pro Pro Pro Thr  Ile Ser Asn 
    1025                 1030                 1035             


Gly Asp  Phe Tyr Ser Asn Asn  Arg Thr Ser Phe His  Asn Gly Thr 
    1040                 1045                 1050             


Val Val  Thr Tyr Gln Cys His  Thr Gly Pro Asp Gly  Glu Gln Leu 
    1055                 1060                 1065             


Phe Glu  Leu Val Gly Glu Arg  Ser Ile Tyr Cys Thr  Ser Lys Asp 
    1070                 1075                 1080             


Asp Gln  Val Gly Val Trp Ser  Ser Pro Pro Pro Arg  Cys Ile Ser 
    1085                 1090                 1095             


Thr Asn  Lys Cys Thr Ala Pro  Glu Val Glu Asn Ala  Ile Arg Val 
    1100                 1105                 1110             


Pro Gly  Asn Arg Ser Phe Phe  Ser Leu Thr Glu Ile  Ile Arg Phe 
    1115                 1120                 1125             


Arg Cys  Gln Pro Gly Phe Val  Met Val Gly Ser His  Thr Val Gln 
    1130                 1135                 1140             


Cys Gln  Thr Asn Gly Arg Trp  Gly Pro Lys Leu Pro  His Cys Ser 
    1145                 1150                 1155             


Arg Val  Cys Gln Pro Pro Pro  Glu Ile Leu His Gly  Glu His Thr 
    1160                 1165                 1170             


Leu Ser  His Gln Asp Asn Phe  Ser Pro Gly Gln Glu  Val Phe Tyr 
    1175                 1180                 1185             


Ser Cys  Glu Pro Ser Tyr Asp  Leu Arg Gly Ala Ala  Ser Leu His 
    1190                 1195                 1200             


Cys Thr  Pro Gln Gly Asp Trp  Ser Pro Glu Ala Pro  Arg Cys Thr 
    1205                 1210                 1215             


Val Lys  Ser Cys Asp Asp Phe  Leu Gly Gln Leu Pro  His Gly Arg 
    1220                 1225                 1230             


Val Leu  Leu Pro Leu Asn Leu  Gln Leu Gly Ala Lys  Val Ser Phe 
    1235                 1240                 1245             


Val Cys  Asp Glu Gly Phe Arg  Leu Lys Gly Arg Ser  Ala Ser His 
    1250                 1255                 1260             


Cys Val  Leu Ala Gly Met Lys  Ala Leu Trp Asn Ser  Ser Val Pro 
    1265                 1270                 1275             


Val Cys  Glu Gln Ile Phe Cys  Pro Asn Pro Pro Ala  Ile Leu Asn 
    1280                 1285                 1290             


Gly Arg  His Thr Gly Thr Pro  Phe Gly Asp Ile Pro  Tyr Gly Lys 
    1295                 1300                 1305             


Glu Ile  Ser Tyr Ala Cys Asp  Thr His Pro Asp Arg  Gly Met Thr 
    1310                 1315                 1320             


Phe Asn  Leu Ile Gly Glu Ser  Ser Ile Arg Cys Thr  Ser Asp Pro 
    1325                 1330                 1335             


Gln Gly  Asn Gly Val Trp Ser  Ser Pro Ala Pro Arg  Cys Glu Leu 
    1340                 1345                 1350             


Ser Val  Pro Ala Ala Cys Pro  His Pro Pro Lys Ile  Gln Asn Gly 
    1355                 1360                 1365             


His Tyr  Ile Gly Gly His Val  Ser Leu Tyr Leu Pro  Gly Met Thr 
    1370                 1375                 1380             


Ile Ser  Tyr Ile Cys Asp Pro  Gly Tyr Leu Leu Val  Gly Lys Gly 
    1385                 1390                 1395             


Phe Ile  Phe Cys Thr Asp Gln  Gly Ile Trp Ser Gln  Leu Asp His 
    1400                 1405                 1410             


Tyr Cys  Lys Glu Val Asn Cys  Ser Phe Pro Leu Phe  Met Asn Gly 
    1415                 1420                 1425             


Ile Ser  Lys Glu Leu Glu Met  Lys Lys Val Tyr His  Tyr Gly Asp 
    1430                 1435                 1440             


Tyr Val  Thr Leu Lys Cys Glu  Asp Gly Tyr Thr Leu  Glu Gly Ser 
    1445                 1450                 1455             


Pro Trp  Ser Gln Cys Gln Ala  Asp Asp Arg Trp Asp  Pro Pro Leu 
    1460                 1465                 1470             


Ala Lys  Cys Thr Ser Arg Thr  His Asp 
    1475                 1480         


<210>  7
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(234)

<400>  7

Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn Leu 
1               5                   10                  15      


Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu Cys 
            20                  25                  30          


Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys Asn 
        35                  40                  45              


Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys Arg 
    50                  55                  60                  


Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg Leu 
                85                  90                  95      


Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val Ile 
            100                 105                 110         


Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu Pro 
        115                 120                 125             


Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe 
    130                 135                 140                 


His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly 
145                 150                 155                 160 


Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser 
                165                 170                 175     


Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile 
            180                 185                 190         


Ile 
    


<210>  8
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(489)

<400>  8

Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn Leu 
1               5                   10                  15      


Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu Cys 
            20                  25                  30          


Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys Asn 
        35                  40                  45              


Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys Arg 
    50                  55                  60                  


Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg Leu 
                85                  90                  95      


Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val Ile 
            100                 105                 110         


Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu Pro 
        115                 120                 125             


Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe 
    130                 135                 140                 


His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly 
145                 150                 155                 160 


Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser 
                165                 170                 175     


Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile 
            180                 185                 190         


Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val 
        195                 200                 205             


Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg 
    210                 215                 220                 


Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln 
225                 230                 235                 240 


Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys 
                245                 250                 255     


Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys 
            260                 265                 270         


Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly 
        275                 280                 285             


Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp 
    290                 295                 300                 


Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe 
305                 310                 315                 320 


Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln 
                325                 330                 335     


Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys 
            340                 345                 350         


Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp 
        355                 360                 365             


Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro 
    370                 375                 380                 


Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro 
385                 390                 395                 400 


Phe Gly Lys Thr Val Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly 
                405                 410                 415     


Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp 
            420                 425                 430         


Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile 
        435                 440                 445             


<210>  9
<211>  1482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(940-1971)

<400>  9

Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys 
1               5                   10                  15      


Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr 
            20                  25                  30          


Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu 
        35                  40                  45              


Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser 
    50                  55                  60                  


Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr 
65                  70                  75                  80  


Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His 
                85                  90                  95      


Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala 
            100                 105                 110         


Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly 
        115                 120                 125             


Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu 
    130                 135                 140                 


Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser 
145                 150                 155                 160 


Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys 
                165                 170                 175     


Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln 
            180                 185                 190         


Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile 
        195                 200                 205             


Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu 
    210                 215                 220                 


Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys 
225                 230                 235                 240 


Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg 
                245                 250                 255     


Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg 
            260                 265                 270         


Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
        275                 280                 285             


Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln 
    290                 295                 300                 


Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp 
305                 310                 315                 320 


Asp Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn 
                325                 330                 335     


Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln 
            340                 345                 350         


Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser 
        355                 360                 365             


Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser 
    370                 375                 380                 


Pro Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val 
385                 390                 395                 400 


Phe Pro Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro His Pro Asp 
                405                 410                 415     


Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr 
            420                 425                 430         


Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
        435                 440                 445             


Gly Ile Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys 
    450                 455                 460                 


Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu 
465                 470                 475                 480 


Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr 
                485                 490                 495     


Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg 
            500                 505                 510         


Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val 
        515                 520                 525             


Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr 
    530                 535                 540                 


Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly 
545                 550                 555                 560 


Asn Thr Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro 
                565                 570                 575     


Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn 
            580                 585                 590         


Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu 
        595                 600                 605             


Gly Ser Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile 
    610                 615                 620                 


Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala 
625                 630                 635                 640 


Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn 
                645                 650                 655     


Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val 
            660                 665                 670         


Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg 
        675                 680                 685             


Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys 
    690                 695                 700                 


Ser Arg Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His Thr 
705                 710                 715                 720 


Pro Ser His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser 
                725                 730                 735     


Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr 
            740                 745                 750         


Pro Gln Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Ala Val Lys Ser 
        755                 760                 765             


Cys Asp Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Phe Pro 
    770                 775                 780                 


Leu Asn Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly 
785                 790                 795                 800 


Phe Arg Leu Lys Gly Ser Ser Val Ser His Cys Val Leu Val Gly Met 
                805                 810                 815     


Arg Ser Leu Trp Asn Asn Ser Val Pro Val Cys Glu His Ile Phe Cys 
            820                 825                 830         


Pro Asn Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Ser 
        835                 840                 845             


Gly Asp Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Thr Cys Asp Pro His 
    850                 855                 860                 


Pro Asp Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Thr Ile Arg 
865                 870                 875                 880 


Cys Thr Ser Asp Pro His Gly Asn Gly Val Trp Ser Ser Pro Ala Pro 
                885                 890                 895     


Arg Cys Glu Leu Ser Val Arg Ala Gly His Cys Lys Thr Pro Glu Gln 
            900                 905                 910         


Phe Pro Phe Ala Ser Pro Thr Ile Pro Ile Asn Asp Phe Glu Phe Pro 
        915                 920                 925             


Val Gly Thr Ser Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Phe Gly Lys 
    930                 935                 940                 


Met Phe Ser Ile Ser Cys Leu Glu Asn Leu Val Trp Ser Ser Val Glu 
945                 950                 955                 960 


Asp Asn Cys Arg Arg Lys Ser Cys Gly Pro Pro Pro Glu Pro Phe Asn 
                965                 970                 975     


Gly Met Val His Ile Asn Thr Asp Thr Gln Phe Gly Ser Thr Val Asn 
            980                 985                 990         


Tyr Ser Cys Asn Glu Gly Phe Arg  Leu Ile Gly Ser Pro  Ser Thr Thr 
        995                 1000                 1005             


Cys Leu  Val Ser Gly Asn Asn  Val Thr Trp Asp Lys  Lys Ala Pro 
    1010                 1015                 1020             


Ile Cys  Glu Ile Ile Ser Cys  Glu Pro Pro Pro Thr  Ile Ser Asn 
    1025                 1030                 1035             


Gly Asp  Phe Tyr Ser Asn Asn  Arg Thr Ser Phe His  Asn Gly Thr 
    1040                 1045                 1050             


Val Val  Thr Tyr Gln Cys His  Thr Gly Pro Asp Gly  Glu Gln Leu 
    1055                 1060                 1065             


Phe Glu  Leu Val Gly Glu Arg  Ser Ile Tyr Cys Thr  Ser Lys Asp 
    1070                 1075                 1080             


Asp Gln  Val Gly Val Trp Ser  Ser Pro Pro Pro Arg  Cys Ile Ser 
    1085                 1090                 1095             


Thr Asn  Lys Cys Thr Ala Pro  Glu Val Glu Asn Ala  Ile Arg Val 
    1100                 1105                 1110             


Pro Gly  Asn Arg Ser Phe Phe  Ser Leu Thr Glu Ile  Ile Arg Phe 
    1115                 1120                 1125             


Arg Cys  Gln Pro Gly Phe Val  Met Val Gly Ser His  Thr Val Gln 
    1130                 1135                 1140             


Cys Gln  Thr Asn Gly Arg Trp  Gly Pro Lys Leu Pro  His Cys Ser 
    1145                 1150                 1155             


Arg Val  Cys Gln Pro Pro Pro  Glu Ile Leu His Gly  Glu His Thr 
    1160                 1165                 1170             


Leu Ser  His Gln Asp Asn Phe  Ser Pro Gly Gln Glu  Val Phe Tyr 
    1175                 1180                 1185             


Ser Cys  Glu Pro Ser Tyr Asp  Leu Arg Gly Ala Ala  Ser Leu His 
    1190                 1195                 1200             


Cys Thr  Pro Gln Gly Asp Trp  Ser Pro Glu Ala Pro  Arg Cys Thr 
    1205                 1210                 1215             


Val Lys  Ser Cys Asp Asp Phe  Leu Gly Gln Leu Pro  His Gly Arg 
    1220                 1225                 1230             


Val Leu  Leu Pro Leu Asn Leu  Gln Leu Gly Ala Lys  Val Ser Phe 
    1235                 1240                 1245             


Val Cys  Asp Glu Gly Phe Arg  Leu Lys Gly Arg Ser  Ala Ser His 
    1250                 1255                 1260             


Cys Val  Leu Ala Gly Met Lys  Ala Leu Trp Asn Ser  Ser Val Pro 
    1265                 1270                 1275             


Val Cys  Glu Gln Ile Phe Cys  Pro Asn Pro Pro Ala  Ile Leu Asn 
    1280                 1285                 1290             


Gly Arg  His Thr Gly Thr Pro  Phe Gly Asp Ile Pro  Tyr Gly Lys 
    1295                 1300                 1305             


Glu Ile  Ser Tyr Ala Cys Asp  Thr His Pro Asp Arg  Gly Met Thr 
    1310                 1315                 1320             


Phe Asn  Leu Ile Gly Glu Ser  Ser Ile Arg Cys Thr  Ser Asp Pro 
    1325                 1330                 1335             


Gln Gly  Asn Gly Val Trp Ser  Ser Pro Ala Pro Arg  Cys Glu Leu 
    1340                 1345                 1350             


Ser Val  Pro Ala Ala Cys Pro  His Pro Pro Lys Ile  Gln Asn Gly 
    1355                 1360                 1365             


His Tyr  Ile Gly Gly His Val  Ser Leu Tyr Leu Pro  Gly Met Thr 
    1370                 1375                 1380             


Ile Ser  Tyr Ile Cys Asp Pro  Gly Tyr Leu Leu Val  Gly Lys Gly 
    1385                 1390                 1395             


Phe Ile  Phe Cys Thr Asp Gln  Gly Ile Trp Ser Gln  Leu Asp His 
    1400                 1405                 1410             


Tyr Cys  Lys Glu Val Asn Cys  Ser Phe Pro Leu Phe  Met Asn Gly 
    1415                 1420                 1425             


Ile Ser  Lys Glu Leu Glu Met  Lys Lys Val Tyr His  Tyr Gly Asp 
    1430                 1435                 1440             


Tyr Val  Thr Leu Lys Cys Glu  Asp Gly Tyr Thr Leu  Glu Gly Ser 
    1445                 1450                 1455             


Pro Trp  Ser Gln Cys Gln Ala  Asp Asp Arg Trp Asp  Pro Pro Leu 
    1460                 1465                 1470             


Ala Lys  Cys Thr Ser Arg Thr  His Asp 
    1475                 1480         


<210>  10
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(490-939)

<400>  10

Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys 
1               5                   10                  15      


Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr 
            20                  25                  30          


Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu 
        35                  40                  45              


Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser 
    50                  55                  60                  


Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr 
65                  70                  75                  80  


Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His 
                85                  90                  95      


Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala 
            100                 105                 110         


Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly 
        115                 120                 125             


Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu 
    130                 135                 140                 


Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser 
145                 150                 155                 160 


Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys 
                165                 170                 175     


Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln 
            180                 185                 190         


Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile 
        195                 200                 205             


Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu 
    210                 215                 220                 


Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys 
225                 230                 235                 240 


Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg 
                245                 250                 255     


Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg 
            260                 265                 270         


Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
        275                 280                 285             


Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln 
    290                 295                 300                 


Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp 
305                 310                 315                 320 


Asp Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn 
                325                 330                 335     


Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln 
            340                 345                 350         


Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser 
        355                 360                 365             


Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser 
    370                 375                 380                 


Pro Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val 
385                 390                 395                 400 


Phe Pro Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro His Pro Asp 
                405                 410                 415     


Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr 
            420                 425                 430         


Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
        435                 440                 445             


Gly Ile 
    450 


<210>  11
<211>  903
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(940-1392)

<400>  11

Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys 
1               5                   10                  15      


Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr 
            20                  25                  30          


Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu 
        35                  40                  45              


Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser 
    50                  55                  60                  


Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr 
65                  70                  75                  80  


Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His 
                85                  90                  95      


Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala 
            100                 105                 110         


Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly 
        115                 120                 125             


Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu 
    130                 135                 140                 


Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser 
145                 150                 155                 160 


Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys 
                165                 170                 175     


Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln 
            180                 185                 190         


Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile 
        195                 200                 205             


Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu 
    210                 215                 220                 


Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys 
225                 230                 235                 240 


Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg 
                245                 250                 255     


Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg 
            260                 265                 270         


Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
        275                 280                 285             


Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln 
    290                 295                 300                 


Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp 
305                 310                 315                 320 


Asp Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn 
                325                 330                 335     


Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln 
            340                 345                 350         


Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser 
        355                 360                 365             


Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser 
    370                 375                 380                 


Pro Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val 
385                 390                 395                 400 


Phe Pro Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro His Pro Asp 
                405                 410                 415     


Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr 
            420                 425                 430         


Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
        435                 440                 445             


Gly Ile Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys 
    450                 455                 460                 


Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu 
465                 470                 475                 480 


Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr 
                485                 490                 495     


Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg 
            500                 505                 510         


Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val 
        515                 520                 525             


Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr 
    530                 535                 540                 


Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly 
545                 550                 555                 560 


Asn Thr Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro 
                565                 570                 575     


Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn 
            580                 585                 590         


Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu 
        595                 600                 605             


Gly Ser Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile 
    610                 615                 620                 


Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala 
625                 630                 635                 640 


Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn 
                645                 650                 655     


Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val 
            660                 665                 670         


Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg 
        675                 680                 685             


Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys 
    690                 695                 700                 


Ser Arg Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His Thr 
705                 710                 715                 720 


Pro Ser His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser 
                725                 730                 735     


Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr 
            740                 745                 750         


Pro Gln Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Ala Val Lys Ser 
        755                 760                 765             


Cys Asp Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Phe Pro 
    770                 775                 780                 


Leu Asn Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly 
785                 790                 795                 800 


Phe Arg Leu Lys Gly Ser Ser Val Ser His Cys Val Leu Val Gly Met 
                805                 810                 815     


Arg Ser Leu Trp Asn Asn Ser Val Pro Val Cys Glu His Ile Phe Cys 
            820                 825                 830         


Pro Asn Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Ser 
        835                 840                 845             


Gly Asp Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Thr Cys Asp Pro His 
    850                 855                 860                 


Pro Asp Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Thr Ile Arg 
865                 870                 875                 880 


Cys Thr Ser Asp Pro His Gly Asn Gly Val Trp Ser Ser Pro Ala Pro 
                885                 890                 895     


Arg Cys Glu Leu Ser Val Arg 
            900             


<210>  12
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(1393-1971)

<400>  12

Ala Gly His Cys Lys Thr Pro Glu Gln Phe Pro Phe Ala Ser Pro Thr 
1               5                   10                  15      


Ile Pro Ile Asn Asp Phe Glu Phe Pro Val Gly Thr Ser Leu Asn Tyr 
            20                  25                  30          


Glu Cys Arg Pro Gly Tyr Phe Gly Lys Met Phe Ser Ile Ser Cys Leu 
        35                  40                  45              


Glu Asn Leu Val Trp Ser Ser Val Glu Asp Asn Cys Arg Arg Lys Ser 
    50                  55                  60                  


Cys Gly Pro Pro Pro Glu Pro Phe Asn Gly Met Val His Ile Asn Thr 
65                  70                  75                  80  


Asp Thr Gln Phe Gly Ser Thr Val Asn Tyr Ser Cys Asn Glu Gly Phe 
                85                  90                  95      


Arg Leu Ile Gly Ser Pro Ser Thr Thr Cys Leu Val Ser Gly Asn Asn 
            100                 105                 110         


Val Thr Trp Asp Lys Lys Ala Pro Ile Cys Glu Ile Ile Ser Cys Glu 
        115                 120                 125             


Pro Pro Pro Thr Ile Ser Asn Gly Asp Phe Tyr Ser Asn Asn Arg Thr 
    130                 135                 140                 


Ser Phe His Asn Gly Thr Val Val Thr Tyr Gln Cys His Thr Gly Pro 
145                 150                 155                 160 


Asp Gly Glu Gln Leu Phe Glu Leu Val Gly Glu Arg Ser Ile Tyr Cys 
                165                 170                 175     


Thr Ser Lys Asp Asp Gln Val Gly Val Trp Ser Ser Pro Pro Pro Arg 
            180                 185                 190         


Cys Ile Ser Thr Asn Lys Cys Thr Ala Pro Glu Val Glu Asn Ala Ile 
        195                 200                 205             


Arg Val Pro Gly Asn Arg Ser Phe Phe Ser Leu Thr Glu Ile Ile Arg 
    210                 215                 220                 


Phe Arg Cys Gln Pro Gly Phe Val Met Val Gly Ser His Thr Val Gln 
225                 230                 235                 240 


Cys Gln Thr Asn Gly Arg Trp Gly Pro Lys Leu Pro His Cys Ser Arg 
                245                 250                 255     


Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His Thr Leu Ser 
            260                 265                 270         


His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
        275                 280                 285             


Pro Ser Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr Pro Gln 
    290                 295                 300                 


Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Thr Val Lys Ser Cys Asp 
305                 310                 315                 320 


Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Leu Pro Leu Asn 
                325                 330                 335     


Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly Phe Arg 
            340                 345                 350         


Leu Lys Gly Arg Ser Ala Ser His Cys Val Leu Ala Gly Met Lys Ala 
        355                 360                 365             


Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Asn 
    370                 375                 380                 


Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Phe Gly Asp 
385                 390                 395                 400 


Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Ala Cys Asp Thr His Pro Asp 
                405                 410                 415     


Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Ser Ile Arg Cys Thr 
            420                 425                 430         


Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
        435                 440                 445             


Glu Leu Ser Val Pro Ala Ala Cys Pro His Pro Pro Lys Ile Gln Asn 
    450                 455                 460                 


Gly His Tyr Ile Gly Gly His Val Ser Leu Tyr Leu Pro Gly Met Thr 
465                 470                 475                 480 


Ile Ser Tyr Ile Cys Asp Pro Gly Tyr Leu Leu Val Gly Lys Gly Phe 
                485                 490                 495     


Ile Phe Cys Thr Asp Gln Gly Ile Trp Ser Gln Leu Asp His Tyr Cys 
            500                 505                 510         


Lys Glu Val Asn Cys Ser Phe Pro Leu Phe Met Asn Gly Ile Ser Lys 
        515                 520                 525             


Glu Leu Glu Met Lys Lys Val Tyr His Tyr Gly Asp Tyr Val Thr Leu 
    530                 535                 540                 


Lys Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Pro Trp Ser Gln Cys 
545                 550                 555                 560 


Gln Ala Asp Asp Arg Trp Asp Pro Pro Leu Ala Lys Cys Thr Ser Arg 
                565                 570                 575     


Thr His Asp 
            


<210>  13
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1 LHR-A

<400>  13

Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn Leu 
1               5                   10                  15      


Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu Cys 
            20                  25                  30          


Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys Asn 
        35                  40                  45              


Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys Arg 
    50                  55                  60                  


Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg Leu 
                85                  90                  95      


Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val Ile 
            100                 105                 110         


Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu Pro 
        115                 120                 125             


Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe 
    130                 135                 140                 


His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly 
145                 150                 155                 160 


Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser 
                165                 170                 175     


Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile 
            180                 185                 190         


Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val 
        195                 200                 205             


Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg 
    210                 215                 220                 


Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln 
225                 230                 235                 240 


Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys 
                245                 250                 255     


Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys 
            260                 265                 270         


Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly 
        275                 280                 285             


Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp 
    290                 295                 300                 


Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe 
305                 310                 315                 320 


Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln 
                325                 330                 335     


Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys 
            340                 345                 350         


Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp 
        355                 360                 365             


Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro 
    370                 375                 380                 


Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro 
385                 390                 395                 400 


Phe Gly Lys Thr Val Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly 
                405                 410                 415     


Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp 
            420                 425                 430         


Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile 
        435                 440                 445             


<210>  14
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1 LHR-B

<400>  14

Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys 
1               5                   10                  15      


Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr 
            20                  25                  30          


Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu 
        35                  40                  45              


Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser 
    50                  55                  60                  


Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr 
65                  70                  75                  80  


Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His 
                85                  90                  95      


Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala 
            100                 105                 110         


Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly 
        115                 120                 125             


Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu 
    130                 135                 140                 


Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser 
145                 150                 155                 160 


Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys 
                165                 170                 175     


Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln 
            180                 185                 190         


Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile 
        195                 200                 205             


Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu 
    210                 215                 220                 


Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys 
225                 230                 235                 240 


Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg 
                245                 250                 255     


Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg 
            260                 265                 270         


Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
        275                 280                 285             


Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln 
    290                 295                 300                 


Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp 
305                 310                 315                 320 


Asp Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn 
                325                 330                 335     


Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln 
            340                 345                 350         


Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser 
        355                 360                 365             


Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser 
    370                 375                 380                 


Pro Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val 
385                 390                 395                 400 


Phe Pro Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro His Pro Asp 
                405                 410                 415     


Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr 
            420                 425                 430         


Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
        435                 440                 445             


Gly Ile 
    450 


<210>  15
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1 LHR-C

<400>  15

Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys 
1               5                   10                  15      


Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr 
            20                  25                  30          


Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu 
        35                  40                  45              


Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser 
    50                  55                  60                  


Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr 
65                  70                  75                  80  


Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His 
                85                  90                  95      


Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr 
            100                 105                 110         


Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly 
        115                 120                 125             


Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu 
    130                 135                 140                 


Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser 
145                 150                 155                 160 


Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys 
                165                 170                 175     


Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln 
            180                 185                 190         


Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile 
        195                 200                 205             


Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu 
    210                 215                 220                 


Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys 
225                 230                 235                 240 


Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg 
                245                 250                 255     


Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His Thr Pro Ser 
            260                 265                 270         


His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
        275                 280                 285             


Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr Pro Gln 
    290                 295                 300                 


Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Ala Val Lys Ser Cys Asp 
305                 310                 315                 320 


Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Phe Pro Leu Asn 
                325                 330                 335     


Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly Phe Arg 
            340                 345                 350         


Leu Lys Gly Ser Ser Val Ser His Cys Val Leu Val Gly Met Arg Ser 
        355                 360                 365             


Leu Trp Asn Asn Ser Val Pro Val Cys Glu His Ile Phe Cys Pro Asn 
    370                 375                 380                 


Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Ser Gly Asp 
385                 390                 395                 400 


Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Thr Cys Asp Pro His Pro Asp 
                405                 410                 415     


Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr 
            420                 425                 430         


Ser Asp Pro His Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
        435                 440                 445             


Glu Leu Ser Val Arg 
    450             


<210>  16
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1 LHR-D

<400>  16

Ala Gly His Cys Lys Thr Pro Glu Gln Phe Pro Phe Ala Ser Pro Thr 
1               5                   10                  15      


Ile Pro Ile Asn Asp Phe Glu Phe Pro Val Gly Thr Ser Leu Asn Tyr 
            20                  25                  30          


Glu Cys Arg Pro Gly Tyr Phe Gly Lys Met Phe Ser Ile Ser Cys Leu 
        35                  40                  45              


Glu Asn Leu Val Trp Ser Ser Val Glu Asp Asn Cys Arg Arg Lys Ser 
    50                  55                  60                  


Cys Gly Pro Pro Pro Glu Pro Phe Asn Gly Met Val His Ile Asn Thr 
65                  70                  75                  80  


Asp Thr Gln Phe Gly Ser Thr Val Asn Tyr Ser Cys Asn Glu Gly Phe 
                85                  90                  95      


Arg Leu Ile Gly Ser Pro Ser Thr Thr Cys Leu Val Ser Gly Asn Asn 
            100                 105                 110         


Val Thr Trp Asp Lys Lys Ala Pro Ile Cys Glu Ile Ile Ser Cys Glu 
        115                 120                 125             


Pro Pro Pro Thr Ile Ser Asn Gly Asp Phe Tyr Ser Asn Asn Arg Thr 
    130                 135                 140                 


Ser Phe His Asn Gly Thr Val Val Thr Tyr Gln Cys His Thr Gly Pro 
145                 150                 155                 160 


Asp Gly Glu Gln Leu Phe Glu Leu Val Gly Glu Arg Ser Ile Tyr Cys 
                165                 170                 175     


Thr Ser Lys Asp Asp Gln Val Gly Val Trp Ser Ser Pro Pro Pro Arg 
            180                 185                 190         


Cys Ile Ser Thr Asn Lys Cys Thr Ala Pro Glu Val Glu Asn Ala Ile 
        195                 200                 205             


Arg Val Pro Gly Asn Arg Ser Phe Phe Ser Leu Thr Glu Ile Ile Arg 
    210                 215                 220                 


Phe Arg Cys Gln Pro Gly Phe Val Met Val Gly Ser His Thr Val Gln 
225                 230                 235                 240 


Cys Gln Thr Asn Gly Arg Trp Gly Pro Lys Leu Pro His Cys Ser Arg 
                245                 250                 255     


Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His Thr Leu Ser 
            260                 265                 270         


His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
        275                 280                 285             


Pro Ser Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr Pro Gln 
    290                 295                 300                 


Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Thr Val Lys Ser Cys Asp 
305                 310                 315                 320 


Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Leu Pro Leu Asn 
                325                 330                 335     


Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly Phe Arg 
            340                 345                 350         


Leu Lys Gly Arg Ser Ala Ser His Cys Val Leu Ala Gly Met Lys Ala 
        355                 360                 365             


Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Asn 
    370                 375                 380                 


Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Phe Gly Asp 
385                 390                 395                 400 


Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Ala Cys Asp Thr His Pro Asp 
                405                 410                 415     


Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Ser Ile Arg Cys Thr 
            420                 425                 430         


Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
        435                 440                 445             


Glu Leu Ser Val Pro Ala Ala Cys Pro His Pro Pro Lys Ile Gln Asn 
    450                 455                 460                 


Gly His Tyr Ile Gly Gly His Val Ser Leu Tyr Leu Pro Gly Met Thr 
465                 470                 475                 480 


Ile Ser Tyr Ile Cys Asp Pro Gly Tyr Leu Leu Val Gly Lys Gly Phe 
                485                 490                 495     


Ile Phe Cys Thr Asp Gln Gly Ile Trp Ser Gln Leu Asp His Tyr Cys 
            500                 505                 510         


Lys Glu Val Asn Cys Ser Phe Pro Leu Phe Met Asn Gly Ile Ser Lys 
        515                 520                 525             


Glu Leu Glu Met Lys Lys Val Tyr His Tyr Gly Asp Tyr Val Thr Leu 
    530                 535                 540                 


Lys Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Pro Trp Ser Gln Cys 
545                 550                 555                 560 


Gln Ala Asp Asp Arg Trp Asp Pro Pro Leu Ala Lys Cys Thr Ser Arg 
                565                 570                 575     


Thr His Asp 
            


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8xHis Tag

<400>  17

His His His His His His His His 
1               5               


<210>  18
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endogenous signal peptide

<400>  18

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly 
        35                  40      


<210>  19
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exogenous signal peptide

<400>  19

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
1               5                   10                  15      


Ala Trp Ala 
            


<210>  20
<211>  1979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(1971)-8His

<400>  20

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Thr 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Thr Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Thr  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Thr Asp 
    1460                 1465                 1470             


Thr Gln  Phe Gly Ser Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Thr Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Thr Ser Phe His Asn  Gly Thr Val Val Thr  Tyr Gln Cys 
    1535                 1540                 1545             


His Thr  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Ser  Leu Thr Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Thr  Val Gln Cys Gln Thr  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Thr Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Thr  His Pro Asp Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Thr Ile Ser Tyr  Ile Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Thr Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg 
    1955                 1960                 1965             


Thr His  Asp His His His His  His His His His 
    1970                 1975                 


<210>  21
<211>  1400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(1392)-8His

<400>  21

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg His His His  His His His 
    1385                 1390                 1395             


His His  
    1400 


<210>  22
<211>  947
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(939)-8His

<400>  22

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile His His His His His 
    930                 935                 940                 


His His His 
945         


<210>  23
<211>  930
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(490-1392)-8His

<400>  23

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
1               5                   10                  15      


Ala Trp Ala Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala 
            20                  25                  30          


Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser 
        35                  40                  45              


Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile 
    50                  55                  60                  


Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys 
65                  70                  75                  80  


Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His 
                85                  90                  95      


Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr 
            100                 105                 110         


Thr Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser 
        115                 120                 125             


Gly Asn Ala Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile 
    130                 135                 140                 


Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr 
145                 150                 155                 160 


Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn 
                165                 170                 175     


Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser 
            180                 185                 190         


Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro 
        195                 200                 205             


Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu 
    210                 215                 220                 


Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu 
225                 230                 235                 240 


Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg 
                245                 250                 255     


Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser 
            260                 265                 270         


Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg 
        275                 280                 285             


Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr 
    290                 295                 300                 


Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys 
305                 310                 315                 320 


Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys 
                325                 330                 335     


Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe 
            340                 345                 350         


Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu 
        355                 360                 365             


Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly 
    370                 375                 380                 


Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe 
385                 390                 395                 400 


Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro 
                405                 410                 415     


Leu Glu Val Phe Pro Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro 
            420                 425                 430         


His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile 
        435                 440                 445             


Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala 
    450                 455                 460                 


Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro Asp His Phe Leu 
465                 470                 475                 480 


Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly 
                485                 490                 495     


Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe 
            500                 505                 510         


Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val 
        515                 520                 525             


Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met 
    530                 535                 540                 


Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser 
545                 550                 555                 560 


Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile 
                565                 570                 575     


Leu Ser Gly Asn Thr Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln 
            580                 585                 590         


Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile 
        595                 600                 605             


Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg 
    610                 615                 620                 


Cys Asn Leu Gly Ser Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu 
625                 630                 635                 640 


Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser 
                645                 650                 655     


Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn 
            660                 665                 670         


Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu 
        675                 680                 685             


Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly 
    690                 695                 700                 


Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu 
705                 710                 715                 720 


Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly 
                725                 730                 735     


Glu His Thr Pro Ser His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val 
            740                 745                 750         


Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Leu 
        755                 760                 765             


His Cys Thr Pro Gln Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Ala 
    770                 775                 780                 


Val Lys Ser Cys Asp Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val 
785                 790                 795                 800 


Leu Phe Pro Leu Asn Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys 
                805                 810                 815     


Asp Glu Gly Phe Arg Leu Lys Gly Ser Ser Val Ser His Cys Val Leu 
            820                 825                 830         


Val Gly Met Arg Ser Leu Trp Asn Asn Ser Val Pro Val Cys Glu His 
        835                 840                 845             


Ile Phe Cys Pro Asn Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly 
    850                 855                 860                 


Thr Pro Ser Gly Asp Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Thr Cys 
865                 870                 875                 880 


Asp Pro His Pro Asp Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser 
                885                 890                 895     


Thr Ile Arg Cys Thr Ser Asp Pro His Gly Asn Gly Val Trp Ser Ser 
            900                 905                 910         


Pro Ala Pro Arg Cys Glu Leu Ser Val Arg His His His His His His 
        915                 920                 925             


His His 
    930 


<210>  24
<211>  1509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(490-1971)-8His

<400>  24

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
1               5                   10                  15      


Ala Trp Ala Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala 
            20                  25                  30          


Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser 
        35                  40                  45              


Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile 
    50                  55                  60                  


Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys 
65                  70                  75                  80  


Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His 
                85                  90                  95      


Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr 
            100                 105                 110         


Thr Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser 
        115                 120                 125             


Gly Asn Ala Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile 
    130                 135                 140                 


Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr 
145                 150                 155                 160 


Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn 
                165                 170                 175     


Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser 
            180                 185                 190         


Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro 
        195                 200                 205             


Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu 
    210                 215                 220                 


Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu 
225                 230                 235                 240 


Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg 
                245                 250                 255     


Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser 
            260                 265                 270         


Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg 
        275                 280                 285             


Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr 
    290                 295                 300                 


Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys 
305                 310                 315                 320 


Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys 
                325                 330                 335     


Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe 
            340                 345                 350         


Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu 
        355                 360                 365             


Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly 
    370                 375                 380                 


Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe 
385                 390                 395                 400 


Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro 
                405                 410                 415     


Leu Glu Val Phe Pro Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro 
            420                 425                 430         


His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile 
        435                 440                 445             


Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala 
    450                 455                 460                 


Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro Asp His Phe Leu 
465                 470                 475                 480 


Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly 
                485                 490                 495     


Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe 
            500                 505                 510         


Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val 
        515                 520                 525             


Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met 
    530                 535                 540                 


Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser 
545                 550                 555                 560 


Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile 
                565                 570                 575     


Leu Ser Gly Asn Thr Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln 
            580                 585                 590         


Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile 
        595                 600                 605             


Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg 
    610                 615                 620                 


Cys Asn Leu Gly Ser Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu 
625                 630                 635                 640 


Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser 
                645                 650                 655     


Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn 
            660                 665                 670         


Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu 
        675                 680                 685             


Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly 
    690                 695                 700                 


Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu 
705                 710                 715                 720 


Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly 
                725                 730                 735     


Glu His Thr Pro Ser His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val 
            740                 745                 750         


Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Leu 
        755                 760                 765             


His Cys Thr Pro Gln Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Ala 
    770                 775                 780                 


Val Lys Ser Cys Asp Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val 
785                 790                 795                 800 


Leu Phe Pro Leu Asn Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys 
                805                 810                 815     


Asp Glu Gly Phe Arg Leu Lys Gly Ser Ser Val Ser His Cys Val Leu 
            820                 825                 830         


Val Gly Met Arg Ser Leu Trp Asn Asn Ser Val Pro Val Cys Glu His 
        835                 840                 845             


Ile Phe Cys Pro Asn Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly 
    850                 855                 860                 


Thr Pro Ser Gly Asp Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Thr Cys 
865                 870                 875                 880 


Asp Pro His Pro Asp Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser 
                885                 890                 895     


Thr Ile Arg Cys Thr Ser Asp Pro His Gly Asn Gly Val Trp Ser Ser 
            900                 905                 910         


Pro Ala Pro Arg Cys Glu Leu Ser Val Arg Ala Gly His Cys Lys Thr 
        915                 920                 925             


Pro Glu Gln Phe Pro Phe Ala Ser Pro Thr Ile Pro Ile Asn Asp Phe 
    930                 935                 940                 


Glu Phe Pro Val Gly Thr Ser Leu Asn Tyr Glu Cys Arg Pro Gly Tyr 
945                 950                 955                 960 


Phe Gly Lys Met Phe Ser Ile Ser Cys Leu Glu Asn Leu Val Trp Ser 
                965                 970                 975     


Ser Val Glu Asp Asn Cys Arg Arg Lys Ser Cys Gly Pro Pro Pro Glu 
            980                 985                 990         


Pro Phe Asn Gly Met Val His Ile  Asn Thr Asp Thr Gln  Phe Gly Ser 
        995                 1000                 1005             


Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe Arg Leu  Ile Gly Ser 
    1010                 1015                 1020             


Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn Asn Val  Thr Trp Asp 
    1025                 1030                 1035             


Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser Cys Glu  Pro Pro Pro 
    1040                 1045                 1050             


Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn Asn Arg  Thr Ser Phe 
    1055                 1060                 1065             


His Asn  Gly Thr Val Val Thr  Tyr Gln Cys His Thr  Gly Pro Asp 
    1070                 1075                 1080             


Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu Arg Ser  Ile Tyr Cys 
    1085                 1090                 1095             


Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp Ser Ser  Pro Pro Pro 
    1100                 1105                 1110             


Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala Pro Glu  Val Glu Asn 
    1115                 1120                 1125             


Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe Phe Ser  Leu Thr Glu 
    1130                 1135                 1140             


Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe Val Met  Val Gly Ser 
    1145                 1150                 1155             


His Thr  Val Gln Cys Gln Thr  Asn Gly Arg Trp Gly  Pro Lys Leu 
    1160                 1165                 1170             


Pro His  Cys Ser Arg Val Cys  Gln Pro Pro Pro Glu  Ile Leu His 
    1175                 1180                 1185             


Gly Glu  His Thr Leu Ser His  Gln Asp Asn Phe Ser  Pro Gly Gln 
    1190                 1195                 1200             


Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr Asp Leu  Arg Gly Ala 
    1205                 1210                 1215             


Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp Trp Ser  Pro Glu Ala 
    1220                 1225                 1230             


Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp Phe Leu  Gly Gln Leu 
    1235                 1240                 1245             


Pro His  Gly Arg Val Leu Leu  Pro Leu Asn Leu Gln  Leu Gly Ala 
    1250                 1255                 1260             


Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe Arg Leu  Lys Gly Arg 
    1265                 1270                 1275             


Ser Ala  Ser His Cys Val Leu  Ala Gly Met Lys Ala  Leu Trp Asn 
    1280                 1285                 1290             


Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe Cys Pro  Asn Pro Pro 
    1295                 1300                 1305             


Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr Pro Phe  Gly Asp Ile 
    1310                 1315                 1320             


Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys Asp Thr  His Pro Asp 
    1325                 1330                 1335             


Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu Ser Ser  Ile Arg Cys 
    1340                 1345                 1350             


Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp Ser Ser  Pro Ala Pro 
    1355                 1360                 1365             


Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys Pro His  Pro Pro Lys 
    1370                 1375                 1380             


Ile Gln  Asn Gly His Tyr Ile  Gly Gly His Val Ser  Leu Tyr Leu 
    1385                 1390                 1395             


Pro Gly  Met Thr Ile Ser Tyr  Ile Cys Asp Pro Gly  Tyr Leu Leu 
    1400                 1405                 1410             


Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp Gln Gly  Ile Trp Ser 
    1415                 1420                 1425             


Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn Cys Ser  Phe Pro Leu 
    1430                 1435                 1440             


Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu Met Lys  Lys Val Tyr 
    1445                 1450                 1455             


His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys Glu Asp  Gly Tyr Thr 
    1460                 1465                 1470             


Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln Ala Asp  Asp Arg Trp 
    1475                 1480                 1485             


Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg Thr His  Asp His His 
    1490                 1495                 1500             


His His  His His His His 
    1505                 


<210>  25
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(234)-8His

<400>  25

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile His His His His His His 
225                 230                 235                 240 


His His 
        


<210>  26
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(489)-8His

<400>  26

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile His His His His His His His 
                485                 490                 495     


His 
    


<210>  27
<211>  1059
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(940-1971)-8His

<400>  27

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
1               5                   10                  15      


Ala Trp Ala Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala 
            20                  25                  30          


Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser 
        35                  40                  45              


Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile 
    50                  55                  60                  


Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys 
65                  70                  75                  80  


Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His 
                85                  90                  95      


Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr 
            100                 105                 110         


Thr Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser 
        115                 120                 125             


Gly Asn Thr Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile 
    130                 135                 140                 


Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr 
145                 150                 155                 160 


Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn 
                165                 170                 175     


Leu Gly Ser Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser 
            180                 185                 190         


Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro 
        195                 200                 205             


Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu 
    210                 215                 220                 


Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu 
225                 230                 235                 240 


Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg 
                245                 250                 255     


Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser 
            260                 265                 270         


Cys Ser Arg Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His 
        275                 280                 285             


Thr Pro Ser His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr 
    290                 295                 300                 


Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys 
305                 310                 315                 320 


Thr Pro Gln Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Ala Val Lys 
                325                 330                 335     


Ser Cys Asp Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Phe 
            340                 345                 350         


Pro Leu Asn Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu 
        355                 360                 365             


Gly Phe Arg Leu Lys Gly Ser Ser Val Ser His Cys Val Leu Val Gly 
    370                 375                 380                 


Met Arg Ser Leu Trp Asn Asn Ser Val Pro Val Cys Glu His Ile Phe 
385                 390                 395                 400 


Cys Pro Asn Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro 
                405                 410                 415     


Ser Gly Asp Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Thr Cys Asp Pro 
            420                 425                 430         


His Pro Asp Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Thr Ile 
        435                 440                 445             


Arg Cys Thr Ser Asp Pro His Gly Asn Gly Val Trp Ser Ser Pro Ala 
    450                 455                 460                 


Pro Arg Cys Glu Leu Ser Val Arg Ala Gly His Cys Lys Thr Pro Glu 
465                 470                 475                 480 


Gln Phe Pro Phe Ala Ser Pro Thr Ile Pro Ile Asn Asp Phe Glu Phe 
                485                 490                 495     


Pro Val Gly Thr Ser Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Phe Gly 
            500                 505                 510         


Lys Met Phe Ser Ile Ser Cys Leu Glu Asn Leu Val Trp Ser Ser Val 
        515                 520                 525             


Glu Asp Asn Cys Arg Arg Lys Ser Cys Gly Pro Pro Pro Glu Pro Phe 
    530                 535                 540                 


Asn Gly Met Val His Ile Asn Thr Asp Thr Gln Phe Gly Ser Thr Val 
545                 550                 555                 560 


Asn Tyr Ser Cys Asn Glu Gly Phe Arg Leu Ile Gly Ser Pro Ser Thr 
                565                 570                 575     


Thr Cys Leu Val Ser Gly Asn Asn Val Thr Trp Asp Lys Lys Ala Pro 
            580                 585                 590         


Ile Cys Glu Ile Ile Ser Cys Glu Pro Pro Pro Thr Ile Ser Asn Gly 
        595                 600                 605             


Asp Phe Tyr Ser Asn Asn Arg Thr Ser Phe His Asn Gly Thr Val Val 
    610                 615                 620                 


Thr Tyr Gln Cys His Thr Gly Pro Asp Gly Glu Gln Leu Phe Glu Leu 
625                 630                 635                 640 


Val Gly Glu Arg Ser Ile Tyr Cys Thr Ser Lys Asp Asp Gln Val Gly 
                645                 650                 655     


Val Trp Ser Ser Pro Pro Pro Arg Cys Ile Ser Thr Asn Lys Cys Thr 
            660                 665                 670         


Ala Pro Glu Val Glu Asn Ala Ile Arg Val Pro Gly Asn Arg Ser Phe 
        675                 680                 685             


Phe Ser Leu Thr Glu Ile Ile Arg Phe Arg Cys Gln Pro Gly Phe Val 
    690                 695                 700                 


Met Val Gly Ser His Thr Val Gln Cys Gln Thr Asn Gly Arg Trp Gly 
705                 710                 715                 720 


Pro Lys Leu Pro His Cys Ser Arg Val Cys Gln Pro Pro Pro Glu Ile 
                725                 730                 735     


Leu His Gly Glu His Thr Leu Ser His Gln Asp Asn Phe Ser Pro Gly 
            740                 745                 750         


Gln Glu Val Phe Tyr Ser Cys Glu Pro Ser Tyr Asp Leu Arg Gly Ala 
        755                 760                 765             


Ala Ser Leu His Cys Thr Pro Gln Gly Asp Trp Ser Pro Glu Ala Pro 
    770                 775                 780                 


Arg Cys Thr Val Lys Ser Cys Asp Asp Phe Leu Gly Gln Leu Pro His 
785                 790                 795                 800 


Gly Arg Val Leu Leu Pro Leu Asn Leu Gln Leu Gly Ala Lys Val Ser 
                805                 810                 815     


Phe Val Cys Asp Glu Gly Phe Arg Leu Lys Gly Arg Ser Ala Ser His 
            820                 825                 830         


Cys Val Leu Ala Gly Met Lys Ala Leu Trp Asn Ser Ser Val Pro Val 
        835                 840                 845             


Cys Glu Gln Ile Phe Cys Pro Asn Pro Pro Ala Ile Leu Asn Gly Arg 
    850                 855                 860                 


His Thr Gly Thr Pro Phe Gly Asp Ile Pro Tyr Gly Lys Glu Ile Ser 
865                 870                 875                 880 


Tyr Ala Cys Asp Thr His Pro Asp Arg Gly Met Thr Phe Asn Leu Ile 
                885                 890                 895     


Gly Glu Ser Ser Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val 
            900                 905                 910         


Trp Ser Ser Pro Ala Pro Arg Cys Glu Leu Ser Val Pro Ala Ala Cys 
        915                 920                 925             


Pro His Pro Pro Lys Ile Gln Asn Gly His Tyr Ile Gly Gly His Val 
    930                 935                 940                 


Ser Leu Tyr Leu Pro Gly Met Thr Ile Ser Tyr Ile Cys Asp Pro Gly 
945                 950                 955                 960 


Tyr Leu Leu Val Gly Lys Gly Phe Ile Phe Cys Thr Asp Gln Gly Ile 
                965                 970                 975     


Trp Ser Gln Leu Asp His Tyr Cys Lys Glu Val Asn Cys Ser Phe Pro 
            980                 985                 990         


Leu Phe Met Asn Gly Ile Ser Lys  Glu Leu Glu Met Lys  Lys Val Tyr 
        995                 1000                 1005             


His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys Glu Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln Ala Asp  Asp Arg Trp 
    1025                 1030                 1035             


Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg Thr His  Asp His His 
    1040                 1045                 1050             


His His  His His His His 
    1055                 


<210>  28
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(490-939)-8His

<400>  28

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
1               5                   10                  15      


Ala Trp Ala Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala 
            20                  25                  30          


Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser 
        35                  40                  45              


Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile 
    50                  55                  60                  


Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys 
65                  70                  75                  80  


Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His 
                85                  90                  95      


Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr 
            100                 105                 110         


Thr Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser 
        115                 120                 125             


Gly Asn Ala Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile 
    130                 135                 140                 


Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr 
145                 150                 155                 160 


Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn 
                165                 170                 175     


Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser 
            180                 185                 190         


Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro 
        195                 200                 205             


Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu 
    210                 215                 220                 


Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu 
225                 230                 235                 240 


Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg 
                245                 250                 255     


Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser 
            260                 265                 270         


Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg 
        275                 280                 285             


Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr 
    290                 295                 300                 


Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys 
305                 310                 315                 320 


Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys 
                325                 330                 335     


Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe 
            340                 345                 350         


Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu 
        355                 360                 365             


Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly 
    370                 375                 380                 


Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe 
385                 390                 395                 400 


Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro 
                405                 410                 415     


Leu Glu Val Phe Pro Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro 
            420                 425                 430         


His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile 
        435                 440                 445             


Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala 
    450                 455                 460                 


Pro Arg Cys Gly Ile His His His His His His His His 
465                 470                 475         


<210>  29
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(940-1392)-8His

<400>  29

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
1               5                   10                  15      


Ala Trp Ala Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala 
            20                  25                  30          


Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser 
        35                  40                  45              


Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile 
    50                  55                  60                  


Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys 
65                  70                  75                  80  


Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His 
                85                  90                  95      


Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr 
            100                 105                 110         


Thr Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser 
        115                 120                 125             


Gly Asn Thr Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile 
    130                 135                 140                 


Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr 
145                 150                 155                 160 


Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn 
                165                 170                 175     


Leu Gly Ser Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser 
            180                 185                 190         


Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro 
        195                 200                 205             


Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu 
    210                 215                 220                 


Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu 
225                 230                 235                 240 


Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg 
                245                 250                 255     


Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser 
            260                 265                 270         


Cys Ser Arg Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His 
        275                 280                 285             


Thr Pro Ser His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr 
    290                 295                 300                 


Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys 
305                 310                 315                 320 


Thr Pro Gln Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Ala Val Lys 
                325                 330                 335     


Ser Cys Asp Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Phe 
            340                 345                 350         


Pro Leu Asn Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu 
        355                 360                 365             


Gly Phe Arg Leu Lys Gly Ser Ser Val Ser His Cys Val Leu Val Gly 
    370                 375                 380                 


Met Arg Ser Leu Trp Asn Asn Ser Val Pro Val Cys Glu His Ile Phe 
385                 390                 395                 400 


Cys Pro Asn Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro 
                405                 410                 415     


Ser Gly Asp Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Thr Cys Asp Pro 
            420                 425                 430         


His Pro Asp Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Thr Ile 
        435                 440                 445             


Arg Cys Thr Ser Asp Pro His Gly Asn Gly Val Trp Ser Ser Pro Ala 
    450                 455                 460                 


Pro Arg Cys Glu Leu Ser Val Arg His His His His His His His His 
465                 470                 475                 480 


<210>  30
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(1393-1971)-8His

<400>  30

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
1               5                   10                  15      


Ala Trp Ala Ala Gly His Cys Lys Thr Pro Glu Gln Phe Pro Phe Ala 
            20                  25                  30          


Ser Pro Thr Ile Pro Ile Asn Asp Phe Glu Phe Pro Val Gly Thr Ser 
        35                  40                  45              


Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Phe Gly Lys Met Phe Ser Ile 
    50                  55                  60                  


Ser Cys Leu Glu Asn Leu Val Trp Ser Ser Val Glu Asp Asn Cys Arg 
65                  70                  75                  80  


Arg Lys Ser Cys Gly Pro Pro Pro Glu Pro Phe Asn Gly Met Val His 
                85                  90                  95      


Ile Asn Thr Asp Thr Gln Phe Gly Ser Thr Val Asn Tyr Ser Cys Asn 
            100                 105                 110         


Glu Gly Phe Arg Leu Ile Gly Ser Pro Ser Thr Thr Cys Leu Val Ser 
        115                 120                 125             


Gly Asn Asn Val Thr Trp Asp Lys Lys Ala Pro Ile Cys Glu Ile Ile 
    130                 135                 140                 


Ser Cys Glu Pro Pro Pro Thr Ile Ser Asn Gly Asp Phe Tyr Ser Asn 
145                 150                 155                 160 


Asn Arg Thr Ser Phe His Asn Gly Thr Val Val Thr Tyr Gln Cys His 
                165                 170                 175     


Thr Gly Pro Asp Gly Glu Gln Leu Phe Glu Leu Val Gly Glu Arg Ser 
            180                 185                 190         


Ile Tyr Cys Thr Ser Lys Asp Asp Gln Val Gly Val Trp Ser Ser Pro 
        195                 200                 205             


Pro Pro Arg Cys Ile Ser Thr Asn Lys Cys Thr Ala Pro Glu Val Glu 
    210                 215                 220                 


Asn Ala Ile Arg Val Pro Gly Asn Arg Ser Phe Phe Ser Leu Thr Glu 
225                 230                 235                 240 


Ile Ile Arg Phe Arg Cys Gln Pro Gly Phe Val Met Val Gly Ser His 
                245                 250                 255     


Thr Val Gln Cys Gln Thr Asn Gly Arg Trp Gly Pro Lys Leu Pro His 
            260                 265                 270         


Cys Ser Arg Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His 
        275                 280                 285             


Thr Leu Ser His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr 
    290                 295                 300                 


Ser Cys Glu Pro Ser Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys 
305                 310                 315                 320 


Thr Pro Gln Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Thr Val Lys 
                325                 330                 335     


Ser Cys Asp Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Leu 
            340                 345                 350         


Pro Leu Asn Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu 
        355                 360                 365             


Gly Phe Arg Leu Lys Gly Arg Ser Ala Ser His Cys Val Leu Ala Gly 
    370                 375                 380                 


Met Lys Ala Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe 
385                 390                 395                 400 


Cys Pro Asn Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro 
                405                 410                 415     


Phe Gly Asp Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Ala Cys Asp Thr 
            420                 425                 430         


His Pro Asp Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Ser Ile 
        435                 440                 445             


Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala 
    450                 455                 460                 


Pro Arg Cys Glu Leu Ser Val Pro Ala Ala Cys Pro His Pro Pro Lys 
465                 470                 475                 480 


Ile Gln Asn Gly His Tyr Ile Gly Gly His Val Ser Leu Tyr Leu Pro 
                485                 490                 495     


Gly Met Thr Ile Ser Tyr Ile Cys Asp Pro Gly Tyr Leu Leu Val Gly 
            500                 505                 510         


Lys Gly Phe Ile Phe Cys Thr Asp Gln Gly Ile Trp Ser Gln Leu Asp 
        515                 520                 525             


His Tyr Cys Lys Glu Val Asn Cys Ser Phe Pro Leu Phe Met Asn Gly 
    530                 535                 540                 


Ile Ser Lys Glu Leu Glu Met Lys Lys Val Tyr His Tyr Gly Asp Tyr 
545                 550                 555                 560 


Val Thr Leu Lys Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Pro Trp 
                565                 570                 575     


Ser Gln Cys Gln Ala Asp Asp Arg Trp Asp Pro Pro Leu Ala Lys Cys 
            580                 585                 590         


Thr Ser Arg Thr His Asp His His His His His His His His 
        595                 600                 605     


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  31

Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser 
1               5                   10              


<210>  32
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human serum albumin

<400>  32

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  33
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc

<400>  33

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ala Ile 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  34
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc

<400>  34

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  35
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS30 peptide linker

<400>  35

Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser 
            20                  25                  30  


<210>  36
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exogenous signal peptide

<400>  36

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  37
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exogenous signal peptide

<400>  37

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  38
<211>  2569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of soluble complement receptor 1 conjugated 
       to HSA (sCR1(1971)-GS13-HSA) with N-terminal endogenous signal 
       peptide

<400>  38

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Thr 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Thr Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Thr  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Thr Asp 
    1460                 1465                 1470             


Thr Gln  Phe Gly Ser Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Thr Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Thr Ser Phe His Asn  Gly Thr Val Val Thr  Tyr Gln Cys 
    1535                 1540                 1545             


His Thr  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Ser  Leu Thr Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Thr  Val Gln Cys Gln Thr  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Thr Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Thr  His Pro Asp Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Thr Ile Ser Tyr  Ile Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Thr Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg 
    1955                 1960                 1965             


Thr His  Asp Gly Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1970                 1975                 1980             


Ser Asp  Ala His Lys Ser Glu  Val Ala His Arg Phe  Lys Asp Leu 
    1985                 1990                 1995             


Gly Glu  Glu Asn Phe Lys Ala  Leu Val Leu Ile Ala  Phe Ala Gln 
    2000                 2005                 2010             


Tyr Leu  Gln Gln Cys Pro Phe  Glu Asp His Val Lys  Leu Val Asn 
    2015                 2020                 2025             


Glu Val  Thr Glu Phe Ala Lys  Thr Cys Val Ala Asp  Glu Ser Ala 
    2030                 2035                 2040             


Glu Asn  Cys Asp Lys Ser Leu  His Thr Leu Phe Gly  Asp Lys Leu 
    2045                 2050                 2055             


Cys Thr  Val Ala Thr Leu Arg  Glu Thr Tyr Gly Glu  Met Ala Asp 
    2060                 2065                 2070             


Cys Cys  Ala Lys Gln Glu Pro  Glu Arg Asn Glu Cys  Phe Leu Gln 
    2075                 2080                 2085             


His Lys  Asp Asp Asn Pro Asn  Leu Pro Arg Leu Val  Arg Pro Glu 
    2090                 2095                 2100             


Val Asp  Val Met Cys Thr Ala  Phe His Asp Asn Glu  Glu Thr Phe 
    2105                 2110                 2115             


Leu Lys  Lys Tyr Leu Tyr Glu  Ile Ala Arg Arg His  Pro Tyr Phe 
    2120                 2125                 2130             


Tyr Ala  Pro Glu Leu Leu Phe  Phe Ala Lys Arg Tyr  Lys Ala Ala 
    2135                 2140                 2145             


Phe Thr  Glu Cys Cys Gln Ala  Ala Asp Lys Ala Ala  Cys Leu Leu 
    2150                 2155                 2160             


Pro Lys  Leu Asp Glu Leu Arg  Asp Glu Gly Lys Ala  Ser Ser Ala 
    2165                 2170                 2175             


Lys Gln  Arg Leu Lys Cys Ala  Ser Leu Gln Lys Phe  Gly Glu Arg 
    2180                 2185                 2190             


Ala Phe  Lys Ala Trp Ala Val  Ala Arg Leu Ser Gln  Arg Phe Pro 
    2195                 2200                 2205             


Lys Ala  Glu Phe Ala Glu Val  Ser Lys Leu Val Thr  Asp Leu Thr 
    2210                 2215                 2220             


Lys Val  His Thr Glu Cys Cys  His Gly Asp Leu Leu  Glu Cys Ala 
    2225                 2230                 2235             


Asp Asp  Arg Ala Asp Leu Ala  Lys Tyr Ile Cys Glu  Asn Gln Asp 
    2240                 2245                 2250             


Ser Ile  Ser Ser Lys Leu Lys  Glu Cys Cys Glu Lys  Pro Leu Leu 
    2255                 2260                 2265             


Glu Lys  Ser His Cys Ile Ala  Glu Val Glu Asn Asp  Glu Met Pro 
    2270                 2275                 2280             


Ala Asp  Leu Pro Ser Leu Ala  Ala Asp Phe Val Glu  Ser Lys Asp 
    2285                 2290                 2295             


Val Cys  Lys Asn Tyr Ala Glu  Ala Lys Asp Val Phe  Leu Gly Met 
    2300                 2305                 2310             


Phe Leu  Tyr Glu Tyr Ala Arg  Arg His Pro Asp Tyr  Ser Val Val 
    2315                 2320                 2325             


Leu Leu  Leu Arg Leu Ala Lys  Thr Tyr Glu Thr Thr  Leu Glu Lys 
    2330                 2335                 2340             


Cys Cys  Ala Ala Ala Asp Pro  His Glu Cys Tyr Ala  Lys Val Phe 
    2345                 2350                 2355             


Asp Glu  Phe Lys Pro Leu Val  Glu Glu Pro Gln Asn  Leu Ile Lys 
    2360                 2365                 2370             


Gln Asn  Cys Glu Leu Phe Glu  Gln Leu Gly Glu Tyr  Lys Phe Gln 
    2375                 2380                 2385             


Asn Ala  Leu Leu Val Arg Tyr  Thr Lys Lys Val Pro  Gln Val Ser 
    2390                 2395                 2400             


Thr Pro  Thr Leu Val Glu Val  Ser Arg Asn Leu Gly  Lys Val Gly 
    2405                 2410                 2415             


Ser Lys  Cys Cys Lys His Pro  Glu Ala Lys Arg Met  Pro Cys Ala 
    2420                 2425                 2430             


Glu Asp  Tyr Leu Ser Val Val  Leu Asn Gln Leu Cys  Val Leu His 
    2435                 2440                 2445             


Glu Lys  Thr Pro Val Ser Asp  Arg Val Thr Lys Cys  Cys Thr Glu 
    2450                 2455                 2460             


Ser Leu  Val Asn Arg Arg Pro  Cys Phe Ser Ala Leu  Glu Val Asp 
    2465                 2470                 2475             


Glu Thr  Tyr Val Pro Lys Glu  Phe Asn Ala Glu Thr  Phe Thr Phe 
    2480                 2485                 2490             


His Ala  Asp Ile Cys Thr Leu  Ser Glu Lys Glu Arg  Gln Ile Lys 
    2495                 2500                 2505             


Lys Gln  Thr Ala Leu Val Glu  Leu Val Lys His Lys  Pro Lys Ala 
    2510                 2515                 2520             


Thr Lys  Glu Gln Leu Lys Ala  Val Met Asp Asp Phe  Ala Ala Phe 
    2525                 2530                 2535             


Val Glu  Lys Cys Cys Lys Ala  Asp Asp Lys Glu Thr  Cys Phe Ala 
    2540                 2545                 2550             


Glu Glu  Gly Lys Lys Leu Val  Ala Ala Ser Gln Ala  Ala Leu Gly 
    2555                 2560                 2565             


Leu 
    


<210>  39
<211>  2552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of soluble complement receptor 1 conjugated 
       to HSA (HSA-GS13-sCR1(42-1971)) with N-terminal HSA signal 
       peptide and pro-peptide

<400>  39

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Gln Cys 
    610                 615                 620                 


Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp 
625                 630                 635                 640 


Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro 
                645                 650                 655     


Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val 
            660                 665                 670         


Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro 
        675                 680                 685             


Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly Ile Gln Phe 
    690                 695                 700                 


Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly 
705                 710                 715                 720 


Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp 
                725                 730                 735     


Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr 
            740                 745                 750         


Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr 
        755                 760                 765             


Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys 
    770                 775                 780                 


Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp 
785                 790                 795                 800 


Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro 
                805                 810                 815     


Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp 
            820                 825                 830         


Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln 
        835                 840                 845             


Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu 
    850                 855                 860                 


Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro 
865                 870                 875                 880 


Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn 
                885                 890                 895     


Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp 
            900                 905                 910         


Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser 
        915                 920                 925             


Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly 
    930                 935                 940                 


Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly 
945                 950                 955                 960 


Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser 
                965                 970                 975     


Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser 
            980                 985                 990         


Ser Val Pro Val Cys Glu Gln Ile  Phe Cys Pro Ser Pro  Pro Val Ile 
        995                 1000                 1005             


Pro Asn  Gly Arg His Thr Gly  Lys Pro Leu Glu Val  Phe Pro Phe 
    1010                 1015                 1020             


Gly Lys  Thr Val Asn Tyr Thr  Cys Asp Pro His Pro  Asp Arg Gly 
    1025                 1030                 1035             


Thr Ser  Phe Asp Leu Ile Gly  Glu Ser Thr Ile Arg  Cys Thr Ser 
    1040                 1045                 1050             


Asp Pro  Gln Gly Asn Gly Val  Trp Ser Ser Pro Ala  Pro Arg Cys 
    1055                 1060                 1065             


Gly Ile  Leu Gly His Cys Gln  Ala Pro Asp His Phe  Leu Phe Ala 
    1070                 1075                 1080             


Lys Leu  Lys Thr Gln Thr Asn  Ala Ser Asp Phe Pro  Ile Gly Thr 
    1085                 1090                 1095             


Ser Leu  Lys Tyr Glu Cys Arg  Pro Glu Tyr Tyr Gly  Arg Pro Phe 
    1100                 1105                 1110             


Ser Ile  Thr Cys Leu Asp Asn  Leu Val Trp Ser Ser  Pro Lys Asp 
    1115                 1120                 1125             


Val Cys  Lys Arg Lys Ser Cys  Lys Thr Pro Pro Asp  Pro Val Asn 
    1130                 1135                 1140             


Gly Met  Val His Val Ile Thr  Asp Ile Gln Val Gly  Ser Arg Ile 
    1145                 1150                 1155             


Asn Tyr  Ser Cys Thr Thr Gly  His Arg Leu Ile Gly  His Ser Ser 
    1160                 1165                 1170             


Ala Glu  Cys Ile Leu Ser Gly  Asn Ala Ala His Trp  Ser Thr Lys 
    1175                 1180                 1185             


Pro Pro  Ile Cys Gln Arg Ile  Pro Cys Gly Leu Pro  Pro Thr Ile 
    1190                 1195                 1200             


Ala Asn  Gly Asp Phe Ile Ser  Thr Asn Arg Glu Asn  Phe His Tyr 
    1205                 1210                 1215             


Gly Ser  Val Val Thr Tyr Arg  Cys Asn Pro Gly Ser  Gly Gly Arg 
    1220                 1225                 1230             


Lys Val  Phe Glu Leu Val Gly  Glu Pro Ser Ile Tyr  Cys Thr Ser 
    1235                 1240                 1245             


Asn Asp  Asp Gln Val Gly Ile  Trp Ser Gly Pro Ala  Pro Gln Cys 
    1250                 1255                 1260             


Ile Ile  Pro Asn Lys Cys Thr  Pro Pro Asn Val Glu  Asn Gly Ile 
    1265                 1270                 1275             


Leu Val  Ser Asp Asn Arg Ser  Leu Phe Ser Leu Asn  Glu Val Val 
    1280                 1285                 1290             


Glu Phe  Arg Cys Gln Pro Gly  Phe Val Met Lys Gly  Pro Arg Arg 
    1295                 1300                 1305             


Val Lys  Cys Gln Ala Leu Asn  Lys Trp Glu Pro Glu  Leu Pro Ser 
    1310                 1315                 1320             


Cys Ser  Arg Val Cys Gln Pro  Pro Pro Asp Val Leu  His Ala Glu 
    1325                 1330                 1335             


Arg Thr  Gln Arg Asp Lys Asp  Asn Phe Ser Pro Gly  Gln Glu Val 
    1340                 1345                 1350             


Phe Tyr  Ser Cys Glu Pro Gly  Tyr Asp Leu Arg Gly  Ala Ala Ser 
    1355                 1360                 1365             


Met Arg  Cys Thr Pro Gln Gly  Asp Trp Ser Pro Ala  Ala Pro Thr 
    1370                 1375                 1380             


Cys Glu  Val Lys Ser Cys Asp  Asp Phe Met Gly Gln  Leu Leu Asn 
    1385                 1390                 1395             


Gly Arg  Val Leu Phe Pro Val  Asn Leu Gln Leu Gly  Ala Lys Val 
    1400                 1405                 1410             


Asp Phe  Val Cys Asp Glu Gly  Phe Gln Leu Lys Gly  Ser Ser Ala 
    1415                 1420                 1425             


Ser Tyr  Cys Val Leu Ala Gly  Met Glu Ser Leu Trp  Asn Ser Ser 
    1430                 1435                 1440             


Val Pro  Val Cys Glu Gln Ile  Phe Cys Pro Ser Pro  Pro Val Ile 
    1445                 1450                 1455             


Pro Asn  Gly Arg His Thr Gly  Lys Pro Leu Glu Val  Phe Pro Phe 
    1460                 1465                 1470             


Gly Lys  Ala Val Asn Tyr Thr  Cys Asp Pro His Pro  Asp Arg Gly 
    1475                 1480                 1485             


Thr Ser  Phe Asp Leu Ile Gly  Glu Ser Thr Ile Arg  Cys Thr Ser 
    1490                 1495                 1500             


Asp Pro  Gln Gly Asn Gly Val  Trp Ser Ser Pro Ala  Pro Arg Cys 
    1505                 1510                 1515             


Gly Ile  Leu Gly His Cys Gln  Ala Pro Asp His Phe  Leu Phe Ala 
    1520                 1525                 1530             


Lys Leu  Lys Thr Gln Thr Asn  Ala Ser Asp Phe Pro  Ile Gly Thr 
    1535                 1540                 1545             


Ser Leu  Lys Tyr Glu Cys Arg  Pro Glu Tyr Tyr Gly  Arg Pro Phe 
    1550                 1555                 1560             


Ser Ile  Thr Cys Leu Asp Asn  Leu Val Trp Ser Ser  Pro Lys Asp 
    1565                 1570                 1575             


Val Cys  Lys Arg Lys Ser Cys  Lys Thr Pro Pro Asp  Pro Val Asn 
    1580                 1585                 1590             


Gly Met  Val His Val Ile Thr  Asp Ile Gln Val Gly  Ser Arg Ile 
    1595                 1600                 1605             


Asn Tyr  Ser Cys Thr Thr Gly  His Arg Leu Ile Gly  His Ser Ser 
    1610                 1615                 1620             


Ala Glu  Cys Ile Leu Ser Gly  Asn Thr Ala His Trp  Ser Thr Lys 
    1625                 1630                 1635             


Pro Pro  Ile Cys Gln Arg Ile  Pro Cys Gly Leu Pro  Pro Thr Ile 
    1640                 1645                 1650             


Ala Asn  Gly Asp Phe Ile Ser  Thr Asn Arg Glu Asn  Phe His Tyr 
    1655                 1660                 1665             


Gly Ser  Val Val Thr Tyr Arg  Cys Asn Leu Gly Ser  Arg Gly Arg 
    1670                 1675                 1680             


Lys Val  Phe Glu Leu Val Gly  Glu Pro Ser Ile Tyr  Cys Thr Ser 
    1685                 1690                 1695             


Asn Asp  Asp Gln Val Gly Ile  Trp Ser Gly Pro Ala  Pro Gln Cys 
    1700                 1705                 1710             


Ile Ile  Pro Asn Lys Cys Thr  Pro Pro Asn Val Glu  Asn Gly Ile 
    1715                 1720                 1725             


Leu Val  Ser Asp Asn Arg Ser  Leu Phe Ser Leu Asn  Glu Val Val 
    1730                 1735                 1740             


Glu Phe  Arg Cys Gln Pro Gly  Phe Val Met Lys Gly  Pro Arg Arg 
    1745                 1750                 1755             


Val Lys  Cys Gln Ala Leu Asn  Lys Trp Glu Pro Glu  Leu Pro Ser 
    1760                 1765                 1770             


Cys Ser  Arg Val Cys Gln Pro  Pro Pro Glu Ile Leu  His Gly Glu 
    1775                 1780                 1785             


His Thr  Pro Ser His Gln Asp  Asn Phe Ser Pro Gly  Gln Glu Val 
    1790                 1795                 1800             


Phe Tyr  Ser Cys Glu Pro Gly  Tyr Asp Leu Arg Gly  Ala Ala Ser 
    1805                 1810                 1815             


Leu His  Cys Thr Pro Gln Gly  Asp Trp Ser Pro Glu  Ala Pro Arg 
    1820                 1825                 1830             


Cys Ala  Val Lys Ser Cys Asp  Asp Phe Leu Gly Gln  Leu Pro His 
    1835                 1840                 1845             


Gly Arg  Val Leu Phe Pro Leu  Asn Leu Gln Leu Gly  Ala Lys Val 
    1850                 1855                 1860             


Ser Phe  Val Cys Asp Glu Gly  Phe Arg Leu Lys Gly  Ser Ser Val 
    1865                 1870                 1875             


Ser His  Cys Val Leu Val Gly  Met Arg Ser Leu Trp  Asn Asn Ser 
    1880                 1885                 1890             


Val Pro  Val Cys Glu His Ile  Phe Cys Pro Asn Pro  Pro Ala Ile 
    1895                 1900                 1905             


Leu Asn  Gly Arg His Thr Gly  Thr Pro Ser Gly Asp  Ile Pro Tyr 
    1910                 1915                 1920             


Gly Lys  Glu Ile Ser Tyr Thr  Cys Asp Pro His Pro  Asp Arg Gly 
    1925                 1930                 1935             


Met Thr  Phe Asn Leu Ile Gly  Glu Ser Thr Ile Arg  Cys Thr Ser 
    1940                 1945                 1950             


Asp Pro  His Gly Asn Gly Val  Trp Ser Ser Pro Ala  Pro Arg Cys 
    1955                 1960                 1965             


Glu Leu  Ser Val Arg Ala Gly  His Cys Lys Thr Pro  Glu Gln Phe 
    1970                 1975                 1980             


Pro Phe  Ala Ser Pro Thr Ile  Pro Ile Asn Asp Phe  Glu Phe Pro 
    1985                 1990                 1995             


Val Gly  Thr Ser Leu Asn Tyr  Glu Cys Arg Pro Gly  Tyr Phe Gly 
    2000                 2005                 2010             


Lys Met  Phe Ser Ile Ser Cys  Leu Glu Asn Leu Val  Trp Ser Ser 
    2015                 2020                 2025             


Val Glu  Asp Asn Cys Arg Arg  Lys Ser Cys Gly Pro  Pro Pro Glu 
    2030                 2035                 2040             


Pro Phe  Asn Gly Met Val His  Ile Asn Thr Asp Thr  Gln Phe Gly 
    2045                 2050                 2055             


Ser Thr  Val Asn Tyr Ser Cys  Asn Glu Gly Phe Arg  Leu Ile Gly 
    2060                 2065                 2070             


Ser Pro  Ser Thr Thr Cys Leu  Val Ser Gly Asn Asn  Val Thr Trp 
    2075                 2080                 2085             


Asp Lys  Lys Ala Pro Ile Cys  Glu Ile Ile Ser Cys  Glu Pro Pro 
    2090                 2095                 2100             


Pro Thr  Ile Ser Asn Gly Asp  Phe Tyr Ser Asn Asn  Arg Thr Ser 
    2105                 2110                 2115             


Phe His  Asn Gly Thr Val Val  Thr Tyr Gln Cys His  Thr Gly Pro 
    2120                 2125                 2130             


Asp Gly  Glu Gln Leu Phe Glu  Leu Val Gly Glu Arg  Ser Ile Tyr 
    2135                 2140                 2145             


Cys Thr  Ser Lys Asp Asp Gln  Val Gly Val Trp Ser  Ser Pro Pro 
    2150                 2155                 2160             


Pro Arg  Cys Ile Ser Thr Asn  Lys Cys Thr Ala Pro  Glu Val Glu 
    2165                 2170                 2175             


Asn Ala  Ile Arg Val Pro Gly  Asn Arg Ser Phe Phe  Ser Leu Thr 
    2180                 2185                 2190             


Glu Ile  Ile Arg Phe Arg Cys  Gln Pro Gly Phe Val  Met Val Gly 
    2195                 2200                 2205             


Ser His  Thr Val Gln Cys Gln  Thr Asn Gly Arg Trp  Gly Pro Lys 
    2210                 2215                 2220             


Leu Pro  His Cys Ser Arg Val  Cys Gln Pro Pro Pro  Glu Ile Leu 
    2225                 2230                 2235             


His Gly  Glu His Thr Leu Ser  His Gln Asp Asn Phe  Ser Pro Gly 
    2240                 2245                 2250             


Gln Glu  Val Phe Tyr Ser Cys  Glu Pro Ser Tyr Asp  Leu Arg Gly 
    2255                 2260                 2265             


Ala Ala  Ser Leu His Cys Thr  Pro Gln Gly Asp Trp  Ser Pro Glu 
    2270                 2275                 2280             


Ala Pro  Arg Cys Thr Val Lys  Ser Cys Asp Asp Phe  Leu Gly Gln 
    2285                 2290                 2295             


Leu Pro  His Gly Arg Val Leu  Leu Pro Leu Asn Leu  Gln Leu Gly 
    2300                 2305                 2310             


Ala Lys  Val Ser Phe Val Cys  Asp Glu Gly Phe Arg  Leu Lys Gly 
    2315                 2320                 2325             


Arg Ser  Ala Ser His Cys Val  Leu Ala Gly Met Lys  Ala Leu Trp 
    2330                 2335                 2340             


Asn Ser  Ser Val Pro Val Cys  Glu Gln Ile Phe Cys  Pro Asn Pro 
    2345                 2350                 2355             


Pro Ala  Ile Leu Asn Gly Arg  His Thr Gly Thr Pro  Phe Gly Asp 
    2360                 2365                 2370             


Ile Pro  Tyr Gly Lys Glu Ile  Ser Tyr Ala Cys Asp  Thr His Pro 
    2375                 2380                 2385             


Asp Arg  Gly Met Thr Phe Asn  Leu Ile Gly Glu Ser  Ser Ile Arg 
    2390                 2395                 2400             


Cys Thr  Ser Asp Pro Gln Gly  Asn Gly Val Trp Ser  Ser Pro Ala 
    2405                 2410                 2415             


Pro Arg  Cys Glu Leu Ser Val  Pro Ala Ala Cys Pro  His Pro Pro 
    2420                 2425                 2430             


Lys Ile  Gln Asn Gly His Tyr  Ile Gly Gly His Val  Ser Leu Tyr 
    2435                 2440                 2445             


Leu Pro  Gly Met Thr Ile Ser  Tyr Ile Cys Asp Pro  Gly Tyr Leu 
    2450                 2455                 2460             


Leu Val  Gly Lys Gly Phe Ile  Phe Cys Thr Asp Gln  Gly Ile Trp 
    2465                 2470                 2475             


Ser Gln  Leu Asp His Tyr Cys  Lys Glu Val Asn Cys  Ser Phe Pro 
    2480                 2485                 2490             


Leu Phe  Met Asn Gly Ile Ser  Lys Glu Leu Glu Met  Lys Lys Val 
    2495                 2500                 2505             


Tyr His  Tyr Gly Asp Tyr Val  Thr Leu Lys Cys Glu  Asp Gly Tyr 
    2510                 2515                 2520             


Thr Leu  Glu Gly Ser Pro Trp  Ser Gln Cys Gln Ala  Asp Asp Arg 
    2525                 2530                 2535             


Trp Asp  Pro Pro Leu Ala Lys  Cys Thr Ser Arg Thr  His Asp 
    2540                 2545                 2550         


<210>  40
<211>  2200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(1971)-IgG4 Fc

<400>  40

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Thr 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Thr Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Thr  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Thr Asp 
    1460                 1465                 1470             


Thr Gln  Phe Gly Ser Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Thr Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Thr Ser Phe His Asn  Gly Thr Val Val Thr  Tyr Gln Cys 
    1535                 1540                 1545             


His Thr  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Ser  Leu Thr Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Thr  Val Gln Cys Gln Thr  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Thr Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Thr  His Pro Asp Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Thr Ile Ser Tyr  Ile Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Thr Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg 
    1955                 1960                 1965             


Thr His  Asp Glu Ser Lys Tyr  Gly Pro Pro Cys Pro  Pro Cys Pro 
    1970                 1975                 1980             


Ala Pro  Glu Phe Leu Gly Gly  Pro Ser Val Phe Leu  Phe Pro Pro 
    1985                 1990                 1995             


Lys Pro  Lys Asp Thr Leu Met  Ile Ser Arg Thr Pro  Glu Val Thr 
    2000                 2005                 2010             


Cys Val  Val Val Asp Val Ser  Gln Glu Asp Pro Glu  Val Gln Phe 
    2015                 2020                 2025             


Asn Trp  Tyr Val Asp Gly Val  Glu Val His Asn Ala  Lys Thr Lys 
    2030                 2035                 2040             


Pro Arg  Glu Glu Gln Phe Asn  Ser Thr Tyr Arg Val  Val Ser Val 
    2045                 2050                 2055             


Leu Thr  Val Leu His Gln Asp  Trp Leu Asn Gly Lys  Glu Tyr Lys 
    2060                 2065                 2070             


Cys Lys  Val Ser Asn Lys Gly  Leu Pro Ser Ser Ile  Glu Lys Thr 
    2075                 2080                 2085             


Ile Ser  Lys Ala Lys Gly Gln  Pro Arg Glu Pro Gln  Val Tyr Thr 
    2090                 2095                 2100             


Leu Pro  Pro Ser Gln Glu Glu  Met Thr Lys Asn Gln  Val Ser Leu 
    2105                 2110                 2115             


Thr Cys  Leu Val Lys Gly Phe  Tyr Pro Ser Asp Ala  Ile Val Glu 
    2120                 2125                 2130             


Trp Glu  Ser Asn Gly Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro 
    2135                 2140                 2145             


Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe Leu Tyr  Ser Arg Leu 
    2150                 2155                 2160             


Thr Val  Asp Lys Ser Arg Trp  Gln Glu Gly Asn Val  Phe Ser Cys 
    2165                 2170                 2175             


Ser Val  Met His Glu Ala Leu  His Asn His Tyr Thr  Gln Lys Ser 
    2180                 2185                 2190             


Leu Ser  Leu Ser Leu Gly Lys  
    2195                 2200 


<210>  41
<211>  2178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc-sCR1(1971)

<400>  41

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala 
            20                  25                  30          


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        35                  40                  45              


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    50                  55                  60                  


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
65                  70                  75                  80  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                85                  90                  95      


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            100                 105                 110         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
        115                 120                 125             


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    130                 135                 140                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
145                 150                 155                 160 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                165                 170                 175     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            180                 185                 190         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        195                 200                 205             


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
    210                 215                 220                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
225                 230                 235                 240 


Ser Leu Ser Leu Ser Leu Gly Lys Gln Cys Asn Ala Pro Glu Trp Leu 
                245                 250                 255     


Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro Ile 
            260                 265                 270         


Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg Pro 
        275                 280                 285             


Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys Asp 
    290                 295                 300                 


Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn Gly 
305                 310                 315                 320 


Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys Tyr 
                325                 330                 335     


Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr Cys 
            340                 345                 350         


Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile Cys 
        355                 360                 365             


Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp Phe 
    370                 375                 380                 


Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr 
385                 390                 395                 400 


Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly 
                405                 410                 415     


Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp 
            420                 425                 430         


Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro 
        435                 440                 445             


Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser 
    450                 455                 460                 


Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys 
465                 470                 475                 480 


Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu 
                485                 490                 495     


Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu His 
            500                 505                 510         


Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu 
        515                 520                 525             


Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser 
    530                 535                 540                 


Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys 
545                 550                 555                 560 


Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly Arg 
                565                 570                 575     


Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe Val 
            580                 585                 590         


Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val 
        595                 600                 605             


Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys Glu 
    610                 615                 620                 


Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His Thr 
625                 630                 635                 640 


Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr Thr 
                645                 650                 655     


Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu 
            660                 665                 670         


Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp Ser 
        675                 680                 685             


Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro Asp 
    690                 695                 700                 


His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe 
705                 710                 715                 720 


Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly 
                725                 730                 735     


Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro 
            740                 745                 750         


Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val 
        755                 760                 765             


Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile 
    770                 775                 780                 


Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser Ala 
785                 790                 795                 800 


Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro Pro 
                805                 810                 815     


Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly 
            820                 825                 830         


Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val 
        835                 840                 845             


Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu 
    850                 855                 860                 


Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly 
865                 870                 875                 880 


Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr 
                885                 890                 895     


Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu 
            900                 905                 910         


Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val 
        915                 920                 925             


Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu 
    930                 935                 940                 


Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val 
945                 950                 955                 960 


Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly 
                965                 970                 975     


Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala 
            980                 985                 990         


Ala Ser Met Arg Cys Thr Pro Gln  Gly Asp Trp Ser Pro  Ala Ala Pro 
        995                 1000                 1005             


Thr Cys  Glu Val Lys Ser Cys  Asp Asp Phe Met Gly  Gln Leu Leu 
    1010                 1015                 1020             


Asn Gly  Arg Val Leu Phe Pro  Val Asn Leu Gln Leu  Gly Ala Lys 
    1025                 1030                 1035             


Val Asp  Phe Val Cys Asp Glu  Gly Phe Gln Leu Lys  Gly Ser Ser 
    1040                 1045                 1050             


Ala Ser  Tyr Cys Val Leu Ala  Gly Met Glu Ser Leu  Trp Asn Ser 
    1055                 1060                 1065             


Ser Val  Pro Val Cys Glu Gln  Ile Phe Cys Pro Ser  Pro Pro Val 
    1070                 1075                 1080             


Ile Pro  Asn Gly Arg His Thr  Gly Lys Pro Leu Glu  Val Phe Pro 
    1085                 1090                 1095             


Phe Gly  Lys Ala Val Asn Tyr  Thr Cys Asp Pro His  Pro Asp Arg 
    1100                 1105                 1110             


Gly Thr  Ser Phe Asp Leu Ile  Gly Glu Ser Thr Ile  Arg Cys Thr 
    1115                 1120                 1125             


Ser Asp  Pro Gln Gly Asn Gly  Val Trp Ser Ser Pro  Ala Pro Arg 
    1130                 1135                 1140             


Cys Gly  Ile Leu Gly His Cys  Gln Ala Pro Asp His  Phe Leu Phe 
    1145                 1150                 1155             


Ala Lys  Leu Lys Thr Gln Thr  Asn Ala Ser Asp Phe  Pro Ile Gly 
    1160                 1165                 1170             


Thr Ser  Leu Lys Tyr Glu Cys  Arg Pro Glu Tyr Tyr  Gly Arg Pro 
    1175                 1180                 1185             


Phe Ser  Ile Thr Cys Leu Asp  Asn Leu Val Trp Ser  Ser Pro Lys 
    1190                 1195                 1200             


Asp Val  Cys Lys Arg Lys Ser  Cys Lys Thr Pro Pro  Asp Pro Val 
    1205                 1210                 1215             


Asn Gly  Met Val His Val Ile  Thr Asp Ile Gln Val  Gly Ser Arg 
    1220                 1225                 1230             


Ile Asn  Tyr Ser Cys Thr Thr  Gly His Arg Leu Ile  Gly His Ser 
    1235                 1240                 1245             


Ser Ala  Glu Cys Ile Leu Ser  Gly Asn Thr Ala His  Trp Ser Thr 
    1250                 1255                 1260             


Lys Pro  Pro Ile Cys Gln Arg  Ile Pro Cys Gly Leu  Pro Pro Thr 
    1265                 1270                 1275             


Ile Ala  Asn Gly Asp Phe Ile  Ser Thr Asn Arg Glu  Asn Phe His 
    1280                 1285                 1290             


Tyr Gly  Ser Val Val Thr Tyr  Arg Cys Asn Leu Gly  Ser Arg Gly 
    1295                 1300                 1305             


Arg Lys  Val Phe Glu Leu Val  Gly Glu Pro Ser Ile  Tyr Cys Thr 
    1310                 1315                 1320             


Ser Asn  Asp Asp Gln Val Gly  Ile Trp Ser Gly Pro  Ala Pro Gln 
    1325                 1330                 1335             


Cys Ile  Ile Pro Asn Lys Cys  Thr Pro Pro Asn Val  Glu Asn Gly 
    1340                 1345                 1350             


Ile Leu  Val Ser Asp Asn Arg  Ser Leu Phe Ser Leu  Asn Glu Val 
    1355                 1360                 1365             


Val Glu  Phe Arg Cys Gln Pro  Gly Phe Val Met Lys  Gly Pro Arg 
    1370                 1375                 1380             


Arg Val  Lys Cys Gln Ala Leu  Asn Lys Trp Glu Pro  Glu Leu Pro 
    1385                 1390                 1395             


Ser Cys  Ser Arg Val Cys Gln  Pro Pro Pro Glu Ile  Leu His Gly 
    1400                 1405                 1410             


Glu His  Thr Pro Ser His Gln  Asp Asn Phe Ser Pro  Gly Gln Glu 
    1415                 1420                 1425             


Val Phe  Tyr Ser Cys Glu Pro  Gly Tyr Asp Leu Arg  Gly Ala Ala 
    1430                 1435                 1440             


Ser Leu  His Cys Thr Pro Gln  Gly Asp Trp Ser Pro  Glu Ala Pro 
    1445                 1450                 1455             


Arg Cys  Ala Val Lys Ser Cys  Asp Asp Phe Leu Gly  Gln Leu Pro 
    1460                 1465                 1470             


His Gly  Arg Val Leu Phe Pro  Leu Asn Leu Gln Leu  Gly Ala Lys 
    1475                 1480                 1485             


Val Ser  Phe Val Cys Asp Glu  Gly Phe Arg Leu Lys  Gly Ser Ser 
    1490                 1495                 1500             


Val Ser  His Cys Val Leu Val  Gly Met Arg Ser Leu  Trp Asn Asn 
    1505                 1510                 1515             


Ser Val  Pro Val Cys Glu His  Ile Phe Cys Pro Asn  Pro Pro Ala 
    1520                 1525                 1530             


Ile Leu  Asn Gly Arg His Thr  Gly Thr Pro Ser Gly  Asp Ile Pro 
    1535                 1540                 1545             


Tyr Gly  Lys Glu Ile Ser Tyr  Thr Cys Asp Pro His  Pro Asp Arg 
    1550                 1555                 1560             


Gly Met  Thr Phe Asn Leu Ile  Gly Glu Ser Thr Ile  Arg Cys Thr 
    1565                 1570                 1575             


Ser Asp  Pro His Gly Asn Gly  Val Trp Ser Ser Pro  Ala Pro Arg 
    1580                 1585                 1590             


Cys Glu  Leu Ser Val Arg Ala  Gly His Cys Lys Thr  Pro Glu Gln 
    1595                 1600                 1605             


Phe Pro  Phe Ala Ser Pro Thr  Ile Pro Ile Asn Asp  Phe Glu Phe 
    1610                 1615                 1620             


Pro Val  Gly Thr Ser Leu Asn  Tyr Glu Cys Arg Pro  Gly Tyr Phe 
    1625                 1630                 1635             


Gly Lys  Met Phe Ser Ile Ser  Cys Leu Glu Asn Leu  Val Trp Ser 
    1640                 1645                 1650             


Ser Val  Glu Asp Asn Cys Arg  Arg Lys Ser Cys Gly  Pro Pro Pro 
    1655                 1660                 1665             


Glu Pro  Phe Asn Gly Met Val  His Ile Asn Thr Asp  Thr Gln Phe 
    1670                 1675                 1680             


Gly Ser  Thr Val Asn Tyr Ser  Cys Asn Glu Gly Phe  Arg Leu Ile 
    1685                 1690                 1695             


Gly Ser  Pro Ser Thr Thr Cys  Leu Val Ser Gly Asn  Asn Val Thr 
    1700                 1705                 1710             


Trp Asp  Lys Lys Ala Pro Ile  Cys Glu Ile Ile Ser  Cys Glu Pro 
    1715                 1720                 1725             


Pro Pro  Thr Ile Ser Asn Gly  Asp Phe Tyr Ser Asn  Asn Arg Thr 
    1730                 1735                 1740             


Ser Phe  His Asn Gly Thr Val  Val Thr Tyr Gln Cys  His Thr Gly 
    1745                 1750                 1755             


Pro Asp  Gly Glu Gln Leu Phe  Glu Leu Val Gly Glu  Arg Ser Ile 
    1760                 1765                 1770             


Tyr Cys  Thr Ser Lys Asp Asp  Gln Val Gly Val Trp  Ser Ser Pro 
    1775                 1780                 1785             


Pro Pro  Arg Cys Ile Ser Thr  Asn Lys Cys Thr Ala  Pro Glu Val 
    1790                 1795                 1800             


Glu Asn  Ala Ile Arg Val Pro  Gly Asn Arg Ser Phe  Phe Ser Leu 
    1805                 1810                 1815             


Thr Glu  Ile Ile Arg Phe Arg  Cys Gln Pro Gly Phe  Val Met Val 
    1820                 1825                 1830             


Gly Ser  His Thr Val Gln Cys  Gln Thr Asn Gly Arg  Trp Gly Pro 
    1835                 1840                 1845             


Lys Leu  Pro His Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1850                 1855                 1860             


Leu His  Gly Glu His Thr Leu  Ser His Gln Asp Asn  Phe Ser Pro 
    1865                 1870                 1875             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Ser Tyr  Asp Leu Arg 
    1880                 1885                 1890             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1895                 1900                 1905             


Glu Ala  Pro Arg Cys Thr Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1910                 1915                 1920             


Gln Leu  Pro His Gly Arg Val  Leu Leu Pro Leu Asn  Leu Gln Leu 
    1925                 1930                 1935             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1940                 1945                 1950             


Gly Arg  Ser Ala Ser His Cys  Val Leu Ala Gly Met  Lys Ala Leu 
    1955                 1960                 1965             


Trp Asn  Ser Ser Val Pro Val  Cys Glu Gln Ile Phe  Cys Pro Asn 
    1970                 1975                 1980             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Phe Gly 
    1985                 1990                 1995             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Ala Cys  Asp Thr His 
    2000                 2005                 2010             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Ser Ile 
    2015                 2020                 2025             


Arg Cys  Thr Ser Asp Pro Gln  Gly Asn Gly Val Trp  Ser Ser Pro 
    2030                 2035                 2040             


Ala Pro  Arg Cys Glu Leu Ser  Val Pro Ala Ala Cys  Pro His Pro 
    2045                 2050                 2055             


Pro Lys  Ile Gln Asn Gly His  Tyr Ile Gly Gly His  Val Ser Leu 
    2060                 2065                 2070             


Tyr Leu  Pro Gly Met Thr Ile  Ser Tyr Ile Cys Asp  Pro Gly Tyr 
    2075                 2080                 2085             


Leu Leu  Val Gly Lys Gly Phe  Ile Phe Cys Thr Asp  Gln Gly Ile 
    2090                 2095                 2100             


Trp Ser  Gln Leu Asp His Tyr  Cys Lys Glu Val Asn  Cys Ser Phe 
    2105                 2110                 2115             


Pro Leu  Phe Met Asn Gly Ile  Ser Lys Glu Leu Glu  Met Lys Lys 
    2120                 2125                 2130             


Val Tyr  His Tyr Gly Asp Tyr  Val Thr Leu Lys Cys  Glu Asp Gly 
    2135                 2140                 2145             


Tyr Thr  Leu Glu Gly Ser Pro  Trp Ser Gln Cys Gln  Ala Asp Asp 
    2150                 2155                 2160             


Arg Trp  Asp Pro Pro Leu Ala  Lys Cys Thr Ser Arg  Thr His Asp 
    2165                 2170                 2175             


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of HSA pro-peptide

<400>  42

Arg Gly Val Phe Arg Arg 
1               5       


<210>  43
<211>  1990
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(1392)-GS-HSA

<400>  43

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Gly Ser Gly  Gly Ser Gly 
    1385                 1390                 1395             


Gly Ser  Gly Gly Ser Gly Ser  Asp Ala His Lys Ser  Glu Val Ala 
    1400                 1405                 1410             


His Arg  Phe Lys Asp Leu Gly  Glu Glu Asn Phe Lys  Ala Leu Val 
    1415                 1420                 1425             


Leu Ile  Ala Phe Ala Gln Tyr  Leu Gln Gln Cys Pro  Phe Glu Asp 
    1430                 1435                 1440             


His Val  Lys Leu Val Asn Glu  Val Thr Glu Phe Ala  Lys Thr Cys 
    1445                 1450                 1455             


Val Ala  Asp Glu Ser Ala Glu  Asn Cys Asp Lys Ser  Leu His Thr 
    1460                 1465                 1470             


Leu Phe  Gly Asp Lys Leu Cys  Thr Val Ala Thr Leu  Arg Glu Thr 
    1475                 1480                 1485             


Tyr Gly  Glu Met Ala Asp Cys  Cys Ala Lys Gln Glu  Pro Glu Arg 
    1490                 1495                 1500             


Asn Glu  Cys Phe Leu Gln His  Lys Asp Asp Asn Pro  Asn Leu Pro 
    1505                 1510                 1515             


Arg Leu  Val Arg Pro Glu Val  Asp Val Met Cys Thr  Ala Phe His 
    1520                 1525                 1530             


Asp Asn  Glu Glu Thr Phe Leu  Lys Lys Tyr Leu Tyr  Glu Ile Ala 
    1535                 1540                 1545             


Arg Arg  His Pro Tyr Phe Tyr  Ala Pro Glu Leu Leu  Phe Phe Ala 
    1550                 1555                 1560             


Lys Arg  Tyr Lys Ala Ala Phe  Thr Glu Cys Cys Gln  Ala Ala Asp 
    1565                 1570                 1575             


Lys Ala  Ala Cys Leu Leu Pro  Lys Leu Asp Glu Leu  Arg Asp Glu 
    1580                 1585                 1590             


Gly Lys  Ala Ser Ser Ala Lys  Gln Arg Leu Lys Cys  Ala Ser Leu 
    1595                 1600                 1605             


Gln Lys  Phe Gly Glu Arg Ala  Phe Lys Ala Trp Ala  Val Ala Arg 
    1610                 1615                 1620             


Leu Ser  Gln Arg Phe Pro Lys  Ala Glu Phe Ala Glu  Val Ser Lys 
    1625                 1630                 1635             


Leu Val  Thr Asp Leu Thr Lys  Val His Thr Glu Cys  Cys His Gly 
    1640                 1645                 1650             


Asp Leu  Leu Glu Cys Ala Asp  Asp Arg Ala Asp Leu  Ala Lys Tyr 
    1655                 1660                 1665             


Ile Cys  Glu Asn Gln Asp Ser  Ile Ser Ser Lys Leu  Lys Glu Cys 
    1670                 1675                 1680             


Cys Glu  Lys Pro Leu Leu Glu  Lys Ser His Cys Ile  Ala Glu Val 
    1685                 1690                 1695             


Glu Asn  Asp Glu Met Pro Ala  Asp Leu Pro Ser Leu  Ala Ala Asp 
    1700                 1705                 1710             


Phe Val  Glu Ser Lys Asp Val  Cys Lys Asn Tyr Ala  Glu Ala Lys 
    1715                 1720                 1725             


Asp Val  Phe Leu Gly Met Phe  Leu Tyr Glu Tyr Ala  Arg Arg His 
    1730                 1735                 1740             


Pro Asp  Tyr Ser Val Val Leu  Leu Leu Arg Leu Ala  Lys Thr Tyr 
    1745                 1750                 1755             


Glu Thr  Thr Leu Glu Lys Cys  Cys Ala Ala Ala Asp  Pro His Glu 
    1760                 1765                 1770             


Cys Tyr  Ala Lys Val Phe Asp  Glu Phe Lys Pro Leu  Val Glu Glu 
    1775                 1780                 1785             


Pro Gln  Asn Leu Ile Lys Gln  Asn Cys Glu Leu Phe  Glu Gln Leu 
    1790                 1795                 1800             


Gly Glu  Tyr Lys Phe Gln Asn  Ala Leu Leu Val Arg  Tyr Thr Lys 
    1805                 1810                 1815             


Lys Val  Pro Gln Val Ser Thr  Pro Thr Leu Val Glu  Val Ser Arg 
    1820                 1825                 1830             


Asn Leu  Gly Lys Val Gly Ser  Lys Cys Cys Lys His  Pro Glu Ala 
    1835                 1840                 1845             


Lys Arg  Met Pro Cys Ala Glu  Asp Tyr Leu Ser Val  Val Leu Asn 
    1850                 1855                 1860             


Gln Leu  Cys Val Leu His Glu  Lys Thr Pro Val Ser  Asp Arg Val 
    1865                 1870                 1875             


Thr Lys  Cys Cys Thr Glu Ser  Leu Val Asn Arg Arg  Pro Cys Phe 
    1880                 1885                 1890             


Ser Ala  Leu Glu Val Asp Glu  Thr Tyr Val Pro Lys  Glu Phe Asn 
    1895                 1900                 1905             


Ala Glu  Thr Phe Thr Phe His  Ala Asp Ile Cys Thr  Leu Ser Glu 
    1910                 1915                 1920             


Lys Glu  Arg Gln Ile Lys Lys  Gln Thr Ala Leu Val  Glu Leu Val 
    1925                 1930                 1935             


Lys His  Lys Pro Lys Ala Thr  Lys Glu Gln Leu Lys  Ala Val Met 
    1940                 1945                 1950             


Asp Asp  Phe Ala Ala Phe Val  Glu Lys Cys Cys Lys  Ala Asp Asp 
    1955                 1960                 1965             


Lys Glu  Thr Cys Phe Ala Glu  Glu Gly Lys Lys Leu  Val Ala Ala 
    1970                 1975                 1980             


Ser Gln  Ala Ala Leu Gly Leu  
    1985                 1990 


<210>  44
<211>  1973
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA-GS-sCR1(1392)

<400>  44

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Gln Cys 
    610                 615                 620                 


Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp 
625                 630                 635                 640 


Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro 
                645                 650                 655     


Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val 
            660                 665                 670         


Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro 
        675                 680                 685             


Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly Ile Gln Phe 
    690                 695                 700                 


Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly 
705                 710                 715                 720 


Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp 
                725                 730                 735     


Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr 
            740                 745                 750         


Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr 
        755                 760                 765             


Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys 
    770                 775                 780                 


Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp 
785                 790                 795                 800 


Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro 
                805                 810                 815     


Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp 
            820                 825                 830         


Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln 
        835                 840                 845             


Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu 
    850                 855                 860                 


Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro 
865                 870                 875                 880 


Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn 
                885                 890                 895     


Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp 
            900                 905                 910         


Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser 
        915                 920                 925             


Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly 
    930                 935                 940                 


Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly 
945                 950                 955                 960 


Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser 
                965                 970                 975     


Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser 
            980                 985                 990         


Ser Val Pro Val Cys Glu Gln Ile  Phe Cys Pro Ser Pro  Pro Val Ile 
        995                 1000                 1005             


Pro Asn  Gly Arg His Thr Gly  Lys Pro Leu Glu Val  Phe Pro Phe 
    1010                 1015                 1020             


Gly Lys  Thr Val Asn Tyr Thr  Cys Asp Pro His Pro  Asp Arg Gly 
    1025                 1030                 1035             


Thr Ser  Phe Asp Leu Ile Gly  Glu Ser Thr Ile Arg  Cys Thr Ser 
    1040                 1045                 1050             


Asp Pro  Gln Gly Asn Gly Val  Trp Ser Ser Pro Ala  Pro Arg Cys 
    1055                 1060                 1065             


Gly Ile  Leu Gly His Cys Gln  Ala Pro Asp His Phe  Leu Phe Ala 
    1070                 1075                 1080             


Lys Leu  Lys Thr Gln Thr Asn  Ala Ser Asp Phe Pro  Ile Gly Thr 
    1085                 1090                 1095             


Ser Leu  Lys Tyr Glu Cys Arg  Pro Glu Tyr Tyr Gly  Arg Pro Phe 
    1100                 1105                 1110             


Ser Ile  Thr Cys Leu Asp Asn  Leu Val Trp Ser Ser  Pro Lys Asp 
    1115                 1120                 1125             


Val Cys  Lys Arg Lys Ser Cys  Lys Thr Pro Pro Asp  Pro Val Asn 
    1130                 1135                 1140             


Gly Met  Val His Val Ile Thr  Asp Ile Gln Val Gly  Ser Arg Ile 
    1145                 1150                 1155             


Asn Tyr  Ser Cys Thr Thr Gly  His Arg Leu Ile Gly  His Ser Ser 
    1160                 1165                 1170             


Ala Glu  Cys Ile Leu Ser Gly  Asn Ala Ala His Trp  Ser Thr Lys 
    1175                 1180                 1185             


Pro Pro  Ile Cys Gln Arg Ile  Pro Cys Gly Leu Pro  Pro Thr Ile 
    1190                 1195                 1200             


Ala Asn  Gly Asp Phe Ile Ser  Thr Asn Arg Glu Asn  Phe His Tyr 
    1205                 1210                 1215             


Gly Ser  Val Val Thr Tyr Arg  Cys Asn Pro Gly Ser  Gly Gly Arg 
    1220                 1225                 1230             


Lys Val  Phe Glu Leu Val Gly  Glu Pro Ser Ile Tyr  Cys Thr Ser 
    1235                 1240                 1245             


Asn Asp  Asp Gln Val Gly Ile  Trp Ser Gly Pro Ala  Pro Gln Cys 
    1250                 1255                 1260             


Ile Ile  Pro Asn Lys Cys Thr  Pro Pro Asn Val Glu  Asn Gly Ile 
    1265                 1270                 1275             


Leu Val  Ser Asp Asn Arg Ser  Leu Phe Ser Leu Asn  Glu Val Val 
    1280                 1285                 1290             


Glu Phe  Arg Cys Gln Pro Gly  Phe Val Met Lys Gly  Pro Arg Arg 
    1295                 1300                 1305             


Val Lys  Cys Gln Ala Leu Asn  Lys Trp Glu Pro Glu  Leu Pro Ser 
    1310                 1315                 1320             


Cys Ser  Arg Val Cys Gln Pro  Pro Pro Asp Val Leu  His Ala Glu 
    1325                 1330                 1335             


Arg Thr  Gln Arg Asp Lys Asp  Asn Phe Ser Pro Gly  Gln Glu Val 
    1340                 1345                 1350             


Phe Tyr  Ser Cys Glu Pro Gly  Tyr Asp Leu Arg Gly  Ala Ala Ser 
    1355                 1360                 1365             


Met Arg  Cys Thr Pro Gln Gly  Asp Trp Ser Pro Ala  Ala Pro Thr 
    1370                 1375                 1380             


Cys Glu  Val Lys Ser Cys Asp  Asp Phe Met Gly Gln  Leu Leu Asn 
    1385                 1390                 1395             


Gly Arg  Val Leu Phe Pro Val  Asn Leu Gln Leu Gly  Ala Lys Val 
    1400                 1405                 1410             


Asp Phe  Val Cys Asp Glu Gly  Phe Gln Leu Lys Gly  Ser Ser Ala 
    1415                 1420                 1425             


Ser Tyr  Cys Val Leu Ala Gly  Met Glu Ser Leu Trp  Asn Ser Ser 
    1430                 1435                 1440             


Val Pro  Val Cys Glu Gln Ile  Phe Cys Pro Ser Pro  Pro Val Ile 
    1445                 1450                 1455             


Pro Asn  Gly Arg His Thr Gly  Lys Pro Leu Glu Val  Phe Pro Phe 
    1460                 1465                 1470             


Gly Lys  Ala Val Asn Tyr Thr  Cys Asp Pro His Pro  Asp Arg Gly 
    1475                 1480                 1485             


Thr Ser  Phe Asp Leu Ile Gly  Glu Ser Thr Ile Arg  Cys Thr Ser 
    1490                 1495                 1500             


Asp Pro  Gln Gly Asn Gly Val  Trp Ser Ser Pro Ala  Pro Arg Cys 
    1505                 1510                 1515             


Gly Ile  Leu Gly His Cys Gln  Ala Pro Asp His Phe  Leu Phe Ala 
    1520                 1525                 1530             


Lys Leu  Lys Thr Gln Thr Asn  Ala Ser Asp Phe Pro  Ile Gly Thr 
    1535                 1540                 1545             


Ser Leu  Lys Tyr Glu Cys Arg  Pro Glu Tyr Tyr Gly  Arg Pro Phe 
    1550                 1555                 1560             


Ser Ile  Thr Cys Leu Asp Asn  Leu Val Trp Ser Ser  Pro Lys Asp 
    1565                 1570                 1575             


Val Cys  Lys Arg Lys Ser Cys  Lys Thr Pro Pro Asp  Pro Val Asn 
    1580                 1585                 1590             


Gly Met  Val His Val Ile Thr  Asp Ile Gln Val Gly  Ser Arg Ile 
    1595                 1600                 1605             


Asn Tyr  Ser Cys Thr Thr Gly  His Arg Leu Ile Gly  His Ser Ser 
    1610                 1615                 1620             


Ala Glu  Cys Ile Leu Ser Gly  Asn Thr Ala His Trp  Ser Thr Lys 
    1625                 1630                 1635             


Pro Pro  Ile Cys Gln Arg Ile  Pro Cys Gly Leu Pro  Pro Thr Ile 
    1640                 1645                 1650             


Ala Asn  Gly Asp Phe Ile Ser  Thr Asn Arg Glu Asn  Phe His Tyr 
    1655                 1660                 1665             


Gly Ser  Val Val Thr Tyr Arg  Cys Asn Leu Gly Ser  Arg Gly Arg 
    1670                 1675                 1680             


Lys Val  Phe Glu Leu Val Gly  Glu Pro Ser Ile Tyr  Cys Thr Ser 
    1685                 1690                 1695             


Asn Asp  Asp Gln Val Gly Ile  Trp Ser Gly Pro Ala  Pro Gln Cys 
    1700                 1705                 1710             


Ile Ile  Pro Asn Lys Cys Thr  Pro Pro Asn Val Glu  Asn Gly Ile 
    1715                 1720                 1725             


Leu Val  Ser Asp Asn Arg Ser  Leu Phe Ser Leu Asn  Glu Val Val 
    1730                 1735                 1740             


Glu Phe  Arg Cys Gln Pro Gly  Phe Val Met Lys Gly  Pro Arg Arg 
    1745                 1750                 1755             


Val Lys  Cys Gln Ala Leu Asn  Lys Trp Glu Pro Glu  Leu Pro Ser 
    1760                 1765                 1770             


Cys Ser  Arg Val Cys Gln Pro  Pro Pro Glu Ile Leu  His Gly Glu 
    1775                 1780                 1785             


His Thr  Pro Ser His Gln Asp  Asn Phe Ser Pro Gly  Gln Glu Val 
    1790                 1795                 1800             


Phe Tyr  Ser Cys Glu Pro Gly  Tyr Asp Leu Arg Gly  Ala Ala Ser 
    1805                 1810                 1815             


Leu His  Cys Thr Pro Gln Gly  Asp Trp Ser Pro Glu  Ala Pro Arg 
    1820                 1825                 1830             


Cys Ala  Val Lys Ser Cys Asp  Asp Phe Leu Gly Gln  Leu Pro His 
    1835                 1840                 1845             


Gly Arg  Val Leu Phe Pro Leu  Asn Leu Gln Leu Gly  Ala Lys Val 
    1850                 1855                 1860             


Ser Phe  Val Cys Asp Glu Gly  Phe Arg Leu Lys Gly  Ser Ser Val 
    1865                 1870                 1875             


Ser His  Cys Val Leu Val Gly  Met Arg Ser Leu Trp  Asn Asn Ser 
    1880                 1885                 1890             


Val Pro  Val Cys Glu His Ile  Phe Cys Pro Asn Pro  Pro Ala Ile 
    1895                 1900                 1905             


Leu Asn  Gly Arg His Thr Gly  Thr Pro Ser Gly Asp  Ile Pro Tyr 
    1910                 1915                 1920             


Gly Lys  Glu Ile Ser Tyr Thr  Cys Asp Pro His Pro  Asp Arg Gly 
    1925                 1930                 1935             


Met Thr  Phe Asn Leu Ile Gly  Glu Ser Thr Ile Arg  Cys Thr Ser 
    1940                 1945                 1950             


Asp Pro  His Gly Asn Gly Val  Trp Ser Ser Pro Ala  Pro Arg Cys 
    1955                 1960                 1965             


Glu Leu  Ser Val Arg 
    1970             


<210>  45
<211>  1621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCR1(1392)-IgG1 Fc

<400>  45

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Glu Ser Lys  Tyr Gly Pro 
    1385                 1390                 1395             


Pro Cys  Pro Pro Cys Pro Ala  Pro Glu Phe Leu Gly  Gly Pro Ser 
    1400                 1405                 1410             


Val Phe  Leu Phe Pro Pro Lys  Pro Lys Asp Thr Leu  Met Ile Ser 
    1415                 1420                 1425             


Arg Thr  Pro Glu Val Thr Cys  Val Val Val Asp Val  Ser Gln Glu 
    1430                 1435                 1440             


Asp Pro  Glu Val Gln Phe Asn  Trp Tyr Val Asp Gly  Val Glu Val 
    1445                 1450                 1455             


His Asn  Ala Lys Thr Lys Pro  Arg Glu Glu Gln Phe  Asn Ser Thr 
    1460                 1465                 1470             


Tyr Arg  Val Val Ser Val Leu  Thr Val Leu His Gln  Asp Trp Leu 
    1475                 1480                 1485             


Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser Asn Lys  Gly Leu Pro 
    1490                 1495                 1500             


Ser Ser  Ile Glu Lys Thr Ile  Ser Lys Ala Lys Gly  Gln Pro Arg 
    1505                 1510                 1515             


Glu Pro  Gln Val Tyr Thr Leu  Pro Pro Ser Gln Glu  Glu Met Thr 
    1520                 1525                 1530             


Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val Lys Gly  Phe Tyr Pro 
    1535                 1540                 1545             


Ser Asp  Ala Ile Val Glu Trp  Glu Ser Asn Gly Gln  Pro Glu Asn 
    1550                 1555                 1560             


Asn Tyr  Lys Thr Thr Pro Pro  Val Leu Asp Ser Asp  Gly Ser Phe 
    1565                 1570                 1575             


Phe Leu  Tyr Ser Arg Leu Thr  Val Asp Lys Ser Arg  Trp Gln Glu 
    1580                 1585                 1590             


Gly Asn  Val Phe Ser Cys Ser  Val Met His Glu Ala  Leu His Asn 
    1595                 1600                 1605             


His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser Leu Gly  Lys 
    1610                 1615                 1620     


<210>  46
<211>  1621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of truncated mature soluble complement 
       receptor 1 conjugated to IgG4 Fc (sCR1(1392)-IgG4 Fc) with 
       N-terminal endogenous signal peptide

<400>  46

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Glu Ser Lys  Tyr Gly Pro 
    1385                 1390                 1395             


Pro Cys  Pro Pro Cys Pro Ala  Pro Glu Phe Leu Gly  Gly Pro Ser 
    1400                 1405                 1410             


Val Phe  Leu Phe Pro Pro Lys  Pro Lys Asp Thr Leu  Met Ile Ser 
    1415                 1420                 1425             


Arg Thr  Pro Glu Val Thr Cys  Val Val Val Asp Val  Ser Gln Glu 
    1430                 1435                 1440             


Asp Pro  Glu Val Gln Phe Asn  Trp Tyr Val Asp Gly  Val Glu Val 
    1445                 1450                 1455             


His Asn  Ala Lys Thr Lys Pro  Arg Glu Glu Gln Phe  Asn Ser Thr 
    1460                 1465                 1470             


Tyr Arg  Val Val Ser Val Leu  Thr Val Leu His Gln  Asp Trp Leu 
    1475                 1480                 1485             


Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser Asn Lys  Gly Leu Pro 
    1490                 1495                 1500             


Ser Ser  Ile Glu Lys Thr Ile  Ser Lys Ala Lys Gly  Gln Pro Arg 
    1505                 1510                 1515             


Glu Pro  Gln Val Tyr Thr Leu  Pro Pro Ser Gln Glu  Glu Met Thr 
    1520                 1525                 1530             


Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val Lys Gly  Phe Tyr Pro 
    1535                 1540                 1545             


Ser Asp  Ala Ile Val Glu Trp  Glu Ser Asn Gly Gln  Pro Glu Asn 
    1550                 1555                 1560             


Asn Tyr  Lys Thr Thr Pro Pro  Val Leu Asp Ser Asp  Gly Ser Phe 
    1565                 1570                 1575             


Phe Leu  Tyr Ser Arg Leu Thr  Val Asp Lys Ser Arg  Trp Gln Glu 
    1580                 1585                 1590             


Gly Asn  Val Phe Ser Cys Ser  Val Met His Glu Ala  Leu His Asn 
    1595                 1600                 1605             


His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser Leu Gly  Lys 
    1610                 1615                 1620     


<210>  47
<211>  1599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc-sCR1(1392)

<400>  47

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala 
            20                  25                  30          


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        35                  40                  45              


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    50                  55                  60                  


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
65                  70                  75                  80  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                85                  90                  95      


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            100                 105                 110         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
        115                 120                 125             


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    130                 135                 140                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
145                 150                 155                 160 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                165                 170                 175     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            180                 185                 190         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        195                 200                 205             


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
    210                 215                 220                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
225                 230                 235                 240 


Ser Leu Ser Leu Ser Leu Gly Lys Gln Cys Asn Ala Pro Glu Trp Leu 
                245                 250                 255     


Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro Ile 
            260                 265                 270         


Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg Pro 
        275                 280                 285             


Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys Asp 
    290                 295                 300                 


Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn Gly 
305                 310                 315                 320 


Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys Tyr 
                325                 330                 335     


Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr Cys 
            340                 345                 350         


Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile Cys 
        355                 360                 365             


Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp Phe 
    370                 375                 380                 


Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr 
385                 390                 395                 400 


Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly 
                405                 410                 415     


Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp 
            420                 425                 430         


Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro 
        435                 440                 445             


Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser 
    450                 455                 460                 


Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys 
465                 470                 475                 480 


Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu 
                485                 490                 495     


Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu His 
            500                 505                 510         


Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu 
        515                 520                 525             


Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser 
    530                 535                 540                 


Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys 
545                 550                 555                 560 


Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly Arg 
                565                 570                 575     


Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe Val 
            580                 585                 590         


Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val 
        595                 600                 605             


Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys Glu 
    610                 615                 620                 


Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His Thr 
625                 630                 635                 640 


Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr Thr 
                645                 650                 655     


Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu 
            660                 665                 670         


Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp Ser 
        675                 680                 685             


Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro Asp 
    690                 695                 700                 


His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe 
705                 710                 715                 720 


Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly 
                725                 730                 735     


Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro 
            740                 745                 750         


Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val 
        755                 760                 765             


Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile 
    770                 775                 780                 


Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser Ala 
785                 790                 795                 800 


Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro Pro 
                805                 810                 815     


Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly 
            820                 825                 830         


Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val 
        835                 840                 845             


Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu 
    850                 855                 860                 


Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly 
865                 870                 875                 880 


Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr 
                885                 890                 895     


Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu 
            900                 905                 910         


Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val 
        915                 920                 925             


Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu 
    930                 935                 940                 


Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val 
945                 950                 955                 960 


Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly 
                965                 970                 975     


Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala 
            980                 985                 990         


Ala Ser Met Arg Cys Thr Pro Gln  Gly Asp Trp Ser Pro  Ala Ala Pro 
        995                 1000                 1005             


Thr Cys  Glu Val Lys Ser Cys  Asp Asp Phe Met Gly  Gln Leu Leu 
    1010                 1015                 1020             


Asn Gly  Arg Val Leu Phe Pro  Val Asn Leu Gln Leu  Gly Ala Lys 
    1025                 1030                 1035             


Val Asp  Phe Val Cys Asp Glu  Gly Phe Gln Leu Lys  Gly Ser Ser 
    1040                 1045                 1050             


Ala Ser  Tyr Cys Val Leu Ala  Gly Met Glu Ser Leu  Trp Asn Ser 
    1055                 1060                 1065             


Ser Val  Pro Val Cys Glu Gln  Ile Phe Cys Pro Ser  Pro Pro Val 
    1070                 1075                 1080             


Ile Pro  Asn Gly Arg His Thr  Gly Lys Pro Leu Glu  Val Phe Pro 
    1085                 1090                 1095             


Phe Gly  Lys Ala Val Asn Tyr  Thr Cys Asp Pro His  Pro Asp Arg 
    1100                 1105                 1110             


Gly Thr  Ser Phe Asp Leu Ile  Gly Glu Ser Thr Ile  Arg Cys Thr 
    1115                 1120                 1125             


Ser Asp  Pro Gln Gly Asn Gly  Val Trp Ser Ser Pro  Ala Pro Arg 
    1130                 1135                 1140             


Cys Gly  Ile Leu Gly His Cys  Gln Ala Pro Asp His  Phe Leu Phe 
    1145                 1150                 1155             


Ala Lys  Leu Lys Thr Gln Thr  Asn Ala Ser Asp Phe  Pro Ile Gly 
    1160                 1165                 1170             


Thr Ser  Leu Lys Tyr Glu Cys  Arg Pro Glu Tyr Tyr  Gly Arg Pro 
    1175                 1180                 1185             


Phe Ser  Ile Thr Cys Leu Asp  Asn Leu Val Trp Ser  Ser Pro Lys 
    1190                 1195                 1200             


Asp Val  Cys Lys Arg Lys Ser  Cys Lys Thr Pro Pro  Asp Pro Val 
    1205                 1210                 1215             


Asn Gly  Met Val His Val Ile  Thr Asp Ile Gln Val  Gly Ser Arg 
    1220                 1225                 1230             


Ile Asn  Tyr Ser Cys Thr Thr  Gly His Arg Leu Ile  Gly His Ser 
    1235                 1240                 1245             


Ser Ala  Glu Cys Ile Leu Ser  Gly Asn Thr Ala His  Trp Ser Thr 
    1250                 1255                 1260             


Lys Pro  Pro Ile Cys Gln Arg  Ile Pro Cys Gly Leu  Pro Pro Thr 
    1265                 1270                 1275             


Ile Ala  Asn Gly Asp Phe Ile  Ser Thr Asn Arg Glu  Asn Phe His 
    1280                 1285                 1290             


Tyr Gly  Ser Val Val Thr Tyr  Arg Cys Asn Leu Gly  Ser Arg Gly 
    1295                 1300                 1305             


Arg Lys  Val Phe Glu Leu Val  Gly Glu Pro Ser Ile  Tyr Cys Thr 
    1310                 1315                 1320             


Ser Asn  Asp Asp Gln Val Gly  Ile Trp Ser Gly Pro  Ala Pro Gln 
    1325                 1330                 1335             


Cys Ile  Ile Pro Asn Lys Cys  Thr Pro Pro Asn Val  Glu Asn Gly 
    1340                 1345                 1350             


Ile Leu  Val Ser Asp Asn Arg  Ser Leu Phe Ser Leu  Asn Glu Val 
    1355                 1360                 1365             


Val Glu  Phe Arg Cys Gln Pro  Gly Phe Val Met Lys  Gly Pro Arg 
    1370                 1375                 1380             


Arg Val  Lys Cys Gln Ala Leu  Asn Lys Trp Glu Pro  Glu Leu Pro 
    1385                 1390                 1395             


Ser Cys  Ser Arg Val Cys Gln  Pro Pro Pro Glu Ile  Leu His Gly 
    1400                 1405                 1410             


Glu His  Thr Pro Ser His Gln  Asp Asn Phe Ser Pro  Gly Gln Glu 
    1415                 1420                 1425             


Val Phe  Tyr Ser Cys Glu Pro  Gly Tyr Asp Leu Arg  Gly Ala Ala 
    1430                 1435                 1440             


Ser Leu  His Cys Thr Pro Gln  Gly Asp Trp Ser Pro  Glu Ala Pro 
    1445                 1450                 1455             


Arg Cys  Ala Val Lys Ser Cys  Asp Asp Phe Leu Gly  Gln Leu Pro 
    1460                 1465                 1470             


His Gly  Arg Val Leu Phe Pro  Leu Asn Leu Gln Leu  Gly Ala Lys 
    1475                 1480                 1485             


Val Ser  Phe Val Cys Asp Glu  Gly Phe Arg Leu Lys  Gly Ser Ser 
    1490                 1495                 1500             


Val Ser  His Cys Val Leu Val  Gly Met Arg Ser Leu  Trp Asn Asn 
    1505                 1510                 1515             


Ser Val  Pro Val Cys Glu His  Ile Phe Cys Pro Asn  Pro Pro Ala 
    1520                 1525                 1530             


Ile Leu  Asn Gly Arg His Thr  Gly Thr Pro Ser Gly  Asp Ile Pro 
    1535                 1540                 1545             


Tyr Gly  Lys Glu Ile Ser Tyr  Thr Cys Asp Pro His  Pro Asp Arg 
    1550                 1555                 1560             


Gly Met  Thr Phe Asn Leu Ile  Gly Glu Ser Thr Ile  Arg Cys Thr 
    1565                 1570                 1575             


Ser Asp  Pro His Gly Asn Gly  Val Trp Ser Ser Pro  Ala Pro Arg 
    1580                 1585                 1590             


Cys Glu  Leu Ser Val Arg 
    1595                 


<210>  48
<211>  1537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of truncated mature soluble complement 
       receptor 1 conjugated to HSA (sCR1(939)-GS13-HSA) with N-terminal
       endogenous signal peptide

<400>  48

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Gly Ser Gly Gly Ser 
    930                 935                 940                 


Gly Gly Ser Gly Gly Ser Gly Ser Asp Ala His Lys Ser Glu Val Ala 
945                 950                 955                 960 


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
                965                 970                 975     


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
            980                 985                 990         


Lys Leu Val Asn Glu Val Thr Glu  Phe Ala Lys Thr Cys  Val Ala Asp 
        995                 1000                 1005             


Glu Ser  Ala Glu Asn Cys Asp  Lys Ser Leu His Thr  Leu Phe Gly 
    1010                 1015                 1020             


Asp Lys  Leu Cys Thr Val Ala  Thr Leu Arg Glu Thr  Tyr Gly Glu 
    1025                 1030                 1035             


Met Ala  Asp Cys Cys Ala Lys  Gln Glu Pro Glu Arg  Asn Glu Cys 
    1040                 1045                 1050             


Phe Leu  Gln His Lys Asp Asp  Asn Pro Asn Leu Pro  Arg Leu Val 
    1055                 1060                 1065             


Arg Pro  Glu Val Asp Val Met  Cys Thr Ala Phe His  Asp Asn Glu 
    1070                 1075                 1080             


Glu Thr  Phe Leu Lys Lys Tyr  Leu Tyr Glu Ile Ala  Arg Arg His 
    1085                 1090                 1095             


Pro Tyr  Phe Tyr Ala Pro Glu  Leu Leu Phe Phe Ala  Lys Arg Tyr 
    1100                 1105                 1110             


Lys Ala  Ala Phe Thr Glu Cys  Cys Gln Ala Ala Asp  Lys Ala Ala 
    1115                 1120                 1125             


Cys Leu  Leu Pro Lys Leu Asp  Glu Leu Arg Asp Glu  Gly Lys Ala 
    1130                 1135                 1140             


Ser Ser  Ala Lys Gln Arg Leu  Lys Cys Ala Ser Leu  Gln Lys Phe 
    1145                 1150                 1155             


Gly Glu  Arg Ala Phe Lys Ala  Trp Ala Val Ala Arg  Leu Ser Gln 
    1160                 1165                 1170             


Arg Phe  Pro Lys Ala Glu Phe  Ala Glu Val Ser Lys  Leu Val Thr 
    1175                 1180                 1185             


Asp Leu  Thr Lys Val His Thr  Glu Cys Cys His Gly  Asp Leu Leu 
    1190                 1195                 1200             


Glu Cys  Ala Asp Asp Arg Ala  Asp Leu Ala Lys Tyr  Ile Cys Glu 
    1205                 1210                 1215             


Asn Gln  Asp Ser Ile Ser Ser  Lys Leu Lys Glu Cys  Cys Glu Lys 
    1220                 1225                 1230             


Pro Leu  Leu Glu Lys Ser His  Cys Ile Ala Glu Val  Glu Asn Asp 
    1235                 1240                 1245             


Glu Met  Pro Ala Asp Leu Pro  Ser Leu Ala Ala Asp  Phe Val Glu 
    1250                 1255                 1260             


Ser Lys  Asp Val Cys Lys Asn  Tyr Ala Glu Ala Lys  Asp Val Phe 
    1265                 1270                 1275             


Leu Gly  Met Phe Leu Tyr Glu  Tyr Ala Arg Arg His  Pro Asp Tyr 
    1280                 1285                 1290             


Ser Val  Val Leu Leu Leu Arg  Leu Ala Lys Thr Tyr  Glu Thr Thr 
    1295                 1300                 1305             


Leu Glu  Lys Cys Cys Ala Ala  Ala Asp Pro His Glu  Cys Tyr Ala 
    1310                 1315                 1320             


Lys Val  Phe Asp Glu Phe Lys  Pro Leu Val Glu Glu  Pro Gln Asn 
    1325                 1330                 1335             


Leu Ile  Lys Gln Asn Cys Glu  Leu Phe Glu Gln Leu  Gly Glu Tyr 
    1340                 1345                 1350             


Lys Phe  Gln Asn Ala Leu Leu  Val Arg Tyr Thr Lys  Lys Val Pro 
    1355                 1360                 1365             


Gln Val  Ser Thr Pro Thr Leu  Val Glu Val Ser Arg  Asn Leu Gly 
    1370                 1375                 1380             


Lys Val  Gly Ser Lys Cys Cys  Lys His Pro Glu Ala  Lys Arg Met 
    1385                 1390                 1395             


Pro Cys  Ala Glu Asp Tyr Leu  Ser Val Val Leu Asn  Gln Leu Cys 
    1400                 1405                 1410             


Val Leu  His Glu Lys Thr Pro  Val Ser Asp Arg Val  Thr Lys Cys 
    1415                 1420                 1425             


Cys Thr  Glu Ser Leu Val Asn  Arg Arg Pro Cys Phe  Ser Ala Leu 
    1430                 1435                 1440             


Glu Val  Asp Glu Thr Tyr Val  Pro Lys Glu Phe Asn  Ala Glu Thr 
    1445                 1450                 1455             


Phe Thr  Phe His Ala Asp Ile  Cys Thr Leu Ser Glu  Lys Glu Arg 
    1460                 1465                 1470             


Gln Ile  Lys Lys Gln Thr Ala  Leu Val Glu Leu Val  Lys His Lys 
    1475                 1480                 1485             


Pro Lys  Ala Thr Lys Glu Gln  Leu Lys Ala Val Met  Asp Asp Phe 
    1490                 1495                 1500             


Ala Ala  Phe Val Glu Lys Cys  Cys Lys Ala Asp Asp  Lys Glu Thr 
    1505                 1510                 1515             


Cys Phe  Ala Glu Glu Gly Lys  Lys Leu Val Ala Ala  Ser Gln Ala 
    1520                 1525                 1530             


Ala Leu  Gly Leu 
    1535         


<210>  49
<211>  1140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of truncated mature soluble complement 
       receptor 1 conjugated to IgG4 Fc (sCR1(939)-IgG4 Fc)) with 
       N-terminal endogenous signal peptide

<400>  49

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Glu Ser Lys Tyr Gly 
    930                 935                 940                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
945                 950                 955                 960 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                965                 970                 975     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            980                 985                 990         


Glu Val Gln Phe Asn Trp Tyr Val  Asp Gly Val Glu Val  His Asn Ala 
        995                 1000                 1005             


Lys Thr  Lys Pro Arg Glu Glu  Gln Phe Asn Ser Thr  Tyr Arg Val 
    1010                 1015                 1020             


Val Ser  Val Leu Thr Val Leu  His Gln Asp Trp Leu  Asn Gly Lys 
    1025                 1030                 1035             


Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Gly Leu Pro  Ser Ser Ile 
    1040                 1045                 1050             


Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln 
    1055                 1060                 1065             


Val Tyr  Thr Leu Pro Pro Ser  Gln Glu Glu Met Thr  Lys Asn Gln 
    1070                 1075                 1080             


Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ala 
    1085                 1090                 1095             


Ile Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 
    1100                 1105                 1110             


Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 
    1115                 1120                 1125             


Ser Arg  Leu Thr Val Asp Lys  Ser Arg Trp Gln Glu  
    1130                 1135                 1140 


<210>  50
<211>  1146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of truncated mature soluble complement 
       receptor 1 conjugated to IgG4 Fc (IgG4 Fc-sCR1(939)) with 
       N-terminal exogenous signal peptide

<400>  50

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala 
            20                  25                  30          


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        35                  40                  45              


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    50                  55                  60                  


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
65                  70                  75                  80  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                85                  90                  95      


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            100                 105                 110         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
        115                 120                 125             


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    130                 135                 140                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
145                 150                 155                 160 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                165                 170                 175     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            180                 185                 190         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        195                 200                 205             


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
    210                 215                 220                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
225                 230                 235                 240 


Ser Leu Ser Leu Ser Leu Gly Lys Gln Cys Asn Ala Pro Glu Trp Leu 
                245                 250                 255     


Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro Ile 
            260                 265                 270         


Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg Pro 
        275                 280                 285             


Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys Asp 
    290                 295                 300                 


Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn Gly 
305                 310                 315                 320 


Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys Tyr 
                325                 330                 335     


Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr Cys 
            340                 345                 350         


Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile Cys 
        355                 360                 365             


Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp Phe 
    370                 375                 380                 


Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr 
385                 390                 395                 400 


Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly 
                405                 410                 415     


Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp 
            420                 425                 430         


Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro 
        435                 440                 445             


Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser 
    450                 455                 460                 


Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys 
465                 470                 475                 480 


Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu 
                485                 490                 495     


Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu His 
            500                 505                 510         


Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu 
        515                 520                 525             


Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser 
    530                 535                 540                 


Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys 
545                 550                 555                 560 


Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly Arg 
                565                 570                 575     


Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe Val 
            580                 585                 590         


Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val 
        595                 600                 605             


Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys Glu 
    610                 615                 620                 


Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His Thr 
625                 630                 635                 640 


Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr Thr 
                645                 650                 655     


Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu 
            660                 665                 670         


Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp Ser 
        675                 680                 685             


Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro Asp 
    690                 695                 700                 


His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe 
705                 710                 715                 720 


Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly 
                725                 730                 735     


Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro 
            740                 745                 750         


Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val 
        755                 760                 765             


Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile 
    770                 775                 780                 


Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser Ala 
785                 790                 795                 800 


Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro Pro 
                805                 810                 815     


Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly 
            820                 825                 830         


Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val 
        835                 840                 845             


Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu 
    850                 855                 860                 


Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly 
865                 870                 875                 880 


Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr 
                885                 890                 895     


Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu 
            900                 905                 910         


Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val 
        915                 920                 925             


Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu 
    930                 935                 940                 


Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val 
945                 950                 955                 960 


Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly 
                965                 970                 975     


Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala 
            980                 985                 990         


Ala Ser Met Arg Cys Thr Pro Gln  Gly Asp Trp Ser Pro  Ala Ala Pro 
        995                 1000                 1005             


Thr Cys  Glu Val Lys Ser Cys  Asp Asp Phe Met Gly  Gln Leu Leu 
    1010                 1015                 1020             


Asn Gly  Arg Val Leu Phe Pro  Val Asn Leu Gln Leu  Gly Ala Lys 
    1025                 1030                 1035             


Val Asp  Phe Val Cys Asp Glu  Gly Phe Gln Leu Lys  Gly Ser Ser 
    1040                 1045                 1050             


Ala Ser  Tyr Cys Val Leu Ala  Gly Met Glu Ser Leu  Trp Asn Ser 
    1055                 1060                 1065             


Ser Val  Pro Val Cys Glu Gln  Ile Phe Cys Pro Ser  Pro Pro Val 
    1070                 1075                 1080             


Ile Pro  Asn Gly Arg His Thr  Gly Lys Pro Leu Glu  Val Phe Pro 
    1085                 1090                 1095             


Phe Gly  Lys Ala Val Asn Tyr  Thr Cys Asp Pro His  Pro Asp Arg 
    1100                 1105                 1110             


Gly Thr  Ser Phe Asp Leu Ile  Gly Glu Ser Thr Ile  Arg Cys Thr 
    1115                 1120                 1125             


Ser Asp  Pro Gln Gly Asn Gly  Val Trp Ser Ser Pro  Ala Pro Arg 
    1130                 1135                 1140             


Cys Gly  Ile 
    1145     


<210>  51
<211>  1977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of truncated mature soluble complement 
       receptor 1 conjugated to HSA (sCR1(1392)-HSA

<400>  51

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Asp Ala His  Lys Ser Glu 
    1385                 1390                 1395             


Val Ala  His Arg Phe Lys Asp  Leu Gly Glu Glu Asn  Phe Lys Ala 
    1400                 1405                 1410             


Leu Val  Leu Ile Ala Phe Ala  Gln Tyr Leu Gln Gln  Cys Pro Phe 
    1415                 1420                 1425             


Glu Asp  His Val Lys Leu Val  Asn Glu Val Thr Glu  Phe Ala Lys 
    1430                 1435                 1440             


Thr Cys  Val Ala Asp Glu Ser  Ala Glu Asn Cys Asp  Lys Ser Leu 
    1445                 1450                 1455             


His Thr  Leu Phe Gly Asp Lys  Leu Cys Thr Val Ala  Thr Leu Arg 
    1460                 1465                 1470             


Glu Thr  Tyr Gly Glu Met Ala  Asp Cys Cys Ala Lys  Gln Glu Pro 
    1475                 1480                 1485             


Glu Arg  Asn Glu Cys Phe Leu  Gln His Lys Asp Asp  Asn Pro Asn 
    1490                 1495                 1500             


Leu Pro  Arg Leu Val Arg Pro  Glu Val Asp Val Met  Cys Thr Ala 
    1505                 1510                 1515             


Phe His  Asp Asn Glu Glu Thr  Phe Leu Lys Lys Tyr  Leu Tyr Glu 
    1520                 1525                 1530             


Ile Ala  Arg Arg His Pro Tyr  Phe Tyr Ala Pro Glu  Leu Leu Phe 
    1535                 1540                 1545             


Phe Ala  Lys Arg Tyr Lys Ala  Ala Phe Thr Glu Cys  Cys Gln Ala 
    1550                 1555                 1560             


Ala Asp  Lys Ala Ala Cys Leu  Leu Pro Lys Leu Asp  Glu Leu Arg 
    1565                 1570                 1575             


Asp Glu  Gly Lys Ala Ser Ser  Ala Lys Gln Arg Leu  Lys Cys Ala 
    1580                 1585                 1590             


Ser Leu  Gln Lys Phe Gly Glu  Arg Ala Phe Lys Ala  Trp Ala Val 
    1595                 1600                 1605             


Ala Arg  Leu Ser Gln Arg Phe  Pro Lys Ala Glu Phe  Ala Glu Val 
    1610                 1615                 1620             


Ser Lys  Leu Val Thr Asp Leu  Thr Lys Val His Thr  Glu Cys Cys 
    1625                 1630                 1635             


His Gly  Asp Leu Leu Glu Cys  Ala Asp Asp Arg Ala  Asp Leu Ala 
    1640                 1645                 1650             


Lys Tyr  Ile Cys Glu Asn Gln  Asp Ser Ile Ser Ser  Lys Leu Lys 
    1655                 1660                 1665             


Glu Cys  Cys Glu Lys Pro Leu  Leu Glu Lys Ser His  Cys Ile Ala 
    1670                 1675                 1680             


Glu Val  Glu Asn Asp Glu Met  Pro Ala Asp Leu Pro  Ser Leu Ala 
    1685                 1690                 1695             


Ala Asp  Phe Val Glu Ser Lys  Asp Val Cys Lys Asn  Tyr Ala Glu 
    1700                 1705                 1710             


Ala Lys  Asp Val Phe Leu Gly  Met Phe Leu Tyr Glu  Tyr Ala Arg 
    1715                 1720                 1725             


Arg His  Pro Asp Tyr Ser Val  Val Leu Leu Leu Arg  Leu Ala Lys 
    1730                 1735                 1740             


Thr Tyr  Glu Thr Thr Leu Glu  Lys Cys Cys Ala Ala  Ala Asp Pro 
    1745                 1750                 1755             


His Glu  Cys Tyr Ala Lys Val  Phe Asp Glu Phe Lys  Pro Leu Val 
    1760                 1765                 1770             


Glu Glu  Pro Gln Asn Leu Ile  Lys Gln Asn Cys Glu  Leu Phe Glu 
    1775                 1780                 1785             


Gln Leu  Gly Glu Tyr Lys Phe  Gln Asn Ala Leu Leu  Val Arg Tyr 
    1790                 1795                 1800             


Thr Lys  Lys Val Pro Gln Val  Ser Thr Pro Thr Leu  Val Glu Val 
    1805                 1810                 1815             


Ser Arg  Asn Leu Gly Lys Val  Gly Ser Lys Cys Cys  Lys His Pro 
    1820                 1825                 1830             


Glu Ala  Lys Arg Met Pro Cys  Ala Glu Asp Tyr Leu  Ser Val Val 
    1835                 1840                 1845             


Leu Asn  Gln Leu Cys Val Leu  His Glu Lys Thr Pro  Val Ser Asp 
    1850                 1855                 1860             


Arg Val  Thr Lys Cys Cys Thr  Glu Ser Leu Val Asn  Arg Arg Pro 
    1865                 1870                 1875             


Cys Phe  Ser Ala Leu Glu Val  Asp Glu Thr Tyr Val  Pro Lys Glu 
    1880                 1885                 1890             


Phe Asn  Ala Glu Thr Phe Thr  Phe His Ala Asp Ile  Cys Thr Leu 
    1895                 1900                 1905             


Ser Glu  Lys Glu Arg Gln Ile  Lys Lys Gln Thr Ala  Leu Val Glu 
    1910                 1915                 1920             


Leu Val  Lys His Lys Pro Lys  Ala Thr Lys Glu Gln  Leu Lys Ala 
    1925                 1930                 1935             


Val Met  Asp Asp Phe Ala Ala  Phe Val Glu Lys Cys  Cys Lys Ala 
    1940                 1945                 1950             


Asp Asp  Lys Glu Thr Cys Phe  Ala Glu Glu Gly Lys  Lys Leu Val 
    1955                 1960                 1965             


Ala Ala  Ser Gln Ala Ala Leu  Gly Leu 
    1970                 1975         


